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https://www.readbyqxmd.com/read/29205437/mrna-traffic-control-reviewed-n6-methyladenosine-m6-a-takes-the-driver-s-seat
#1
REVIEW
Abhirami Visvanathan, Kumaravel Somasundaram
Messenger RNA is a flexible tool box that plays a key role in the dynamic regulation of gene expression. RNA modifications variegate the message conveyed by the mRNA. Similar to DNA and histone modifications, mRNA modifications are reversible and play a key role in the regulation of molecular events. Our understanding about the landscape of RNA modifications is still rudimentary in contrast to DNA and histone modifications. The major obstacle has been the lack of sensitive detection methods since they are non-editing events...
December 4, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/29186607/benefits-and-limitations-of-indocyanine-green-fluorescent-image-guided-surgery-for-spinal-intramedullary-tumors
#2
Toshihiro Takami, Kentaro Naito, Toru Yamagata, Nobuyuki Shimokawa, Kenji Ohata
BACKGROUND: Intraoperative image guidance using near-infrared indocyanine green videoangiography (ICG-VA) has been used to provide real-time angiographic images during vascular or brain tumor surgery, and it is also being used for spine surgery. OBJECTIVE: To further investigate the benefits and limitations of ICG-VA image-guided surgery for spinal intramedullary tumors through retrospective study. METHODS: ICG-VA was used in 48 cases that were treated surgically over the past 5 yr...
December 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29171979/influence-of-a-dynamic-seating-habit-on-lumbar-motor-control-in-schoolchildren
#3
T Fettweis, M N Onkelinx, C Schwartz, C Demoulin, J L Croisier, M Vanderthommen
BACKGROUND: Adequate motor control is considered important for spinal stability and the prevention of low back pain in adulthood and in childhood. OBJECTIVE: Given that the sitting position can affect proprioception, this study aimed to evaluate the influence of using at school a triangular and dynamic cushion on schoolchildren's trunk motor control. METHODS: Thirty 8-year-old schoolchildren were randomized into a control group (n= 15) and a "cushion group" (n= 15), in which the children used the cushion for one year and a half...
November 17, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29170632/transcriptional-and-post-transcriptional-mechanisms-of-the-development-of-neocortical-lamination
#4
REVIEW
Tatiana Popovitchenko, Mladen-Roko Rasin
The neocortex is a laminated brain structure that is the seat of higher cognitive capacity and responses, long-term memory, sensory and emotional functions, and voluntary motor behavior. Proper lamination requires that progenitor cells give rise to a neuron, that the immature neuron can migrate away from its mother cell and past other cells, and finally that the immature neuron can take its place and adopt a mature identity characterized by connectivity and gene expression; thus lamination proceeds through three steps: genesis, migration, and maturation...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29112056/effects-of-a-resistance-training-intervention-on-strength-power-and-performance-in-adolescent-dancers
#5
Rebecca A Dowse, Mike R McGuigan, Craig Harrison
Dowse, RA, McGuigan, MR, and Harrison, C. Effects of a resistance training intervention on strength, power, and performance in adolescent dancers. J Strength Cond Res XX(X): 000-000, 2017-The aim of this study was to determine whether a 9-week resistance training program could have a significant effect on maximum lower-body strength and power, dynamic balance, and dance performance in adolescent dancers. Twelve competitive adolescent female dancers trained in jazz, ballet, and contemporary were recruited from local dance schools and assigned to a resistance training group (dance experience 9...
November 1, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29081263/revisiting-the-merits-of-a-mandatory-large-group-classroom-learning-format-an-md-mba-perspective
#6
Shawn X Li, Roshini Pinto-Powell
The role of classroom learning in medical education is rapidly changing. To promote active learning and reduce student stress, medical schools have adopted policies such as pass/fail curriculums and recorded lectures. These policies along with the rising importance of the USMLE (United States Medical Licensing Examination) exams have made asynchronous learning popular to the detriment of classroom learning. In contrast to this model, modern day business schools employ mandatory large group classes with assigned seating and cold-calling...
2017: Medical Education Online
https://www.readbyqxmd.com/read/29075428/obtaining-natural-sit-to-stand-motion-with-a-biomimetic-controller-for-powered-knee-prostheses
#7
Molei Wu, Md Rejwanul Haque, Xiangrong Shen
Standing up from a seated position is a common activity in people's daily life. However, for transfemoral (i.e., above-knee) amputees fitted with traditional passive prostheses, the sit-to-stand (STS) transition is highly challenging, due to the inability of the prosthetic joints in generating torque and power output. In this paper, the authors present a new STS control approach for powered lower limb prostheses, which is able to regulate the power delivery of the prosthetic knee joint to obtain natural STS motion similar to that displayed by healthy subjects...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29064302/study-of-chest-injuries-to-3yo-child-occupants-seated-in-impact-shield-and-5-point-harness-crss
#8
Yong Han, Di Pan, Jun Ouyang, Lei Qian, Koji Mizuno, Anguo Cang
OBJECTIVE: To investigate whether the 5-point harness or the impact shield CRS or both has the potential to cause chest injuries to children. This is determined by examining whether the loading to the chest reaches the internal organ injury threshold for children. METHOD: The chest injury risk to a child occupant in a child restraint system (CRS) was investigated using Q3 dummy tests, finite element (FE) simulations (Q3 dummy and human models) and animal tests. The investigation was done for two types of CRSs (i...
October 24, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29053865/beta-burst-dynamics-in-parkinson-s-disease-off-and-on-dopaminergic-medication
#9
Gerd Tinkhauser, Alek Pogosyan, Huiling Tan, Damian M Herz, Andrea A Kühn, Peter Brown
Exaggerated basal ganglia beta activity (13-35 Hz) is commonly found in patients with Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of suppression being correlated with the improvement in motor symptoms. Importantly, beta activity is not continuously elevated, but fluctuates to give beta bursts. The percentage number of longer beta bursts in a given interval is positively correlated with clinical impairment in Parkinson's disease patients. Here we determine whether the characteristics of beta bursts are dependent on dopaminergic state...
November 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29051881/fracture-management-in-pyknodysostosis-a-rare-case-report
#10
G Subramanya Gandhi, V Vijayanarasimhan, Lionel John, S Kailash, E Sathish Balaji
INTRODUCTION: Pyknodysostosis is congenital osteosclerotic skeletal dysplasia of a rare entity. It is an autosomal recessive disease which presents with short stature and generalized osteosclerosis of skeleton as result of decreased bone turnover. Here, the authors report a case of pyknodysostosis who presented to our emergency room with a pathological fracture in the shaft of the femur for which operative intervention was carried out. CASE REPORT: A 30-year-old female presented to our emergency room with a history of trivial injury to right thigh region and was diagnosed as fracture in her right femur shaft region...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29034325/collection-of-viable-aerosolized-influenza-virus-and-other-respiratory-viruses-in-a-student-health-care-center-through-water-based-condensation-growth
#11
Maohua Pan, Tania S Bonny, Julia Loeb, Xiao Jiang, John A Lednicky, Arantzazu Eiguren-Fernandez, Susanne Hering, Z Hugh Fan, Chang-Yu Wu
The dynamics and significance of aerosol transmission of respiratory viruses are still controversial, for the major reasons that virus aerosols are inefficiently collected by commonly used air samplers and that the collected viruses are inactivated by the collection method. Without knowledge of virus viability, infection risk analyses lack accuracy. This pilot study was performed to (i) determine whether infectious (viable) respiratory viruses in aerosols could be collected from air in a real world environment by the viable virus aerosol sampler (VIVAS), (ii) compare and contrast the efficacy of the standard bioaerosol sampler, the BioSampler, with that of the VIVAS for the collection of airborne viruses in a real world environment, and (iii) gain insights for the use of the VIVAS for respiratory virus sampling...
September 2017: MSphere
https://www.readbyqxmd.com/read/28976493/accelerometer-assessed-physical-activity-in-epidemiology-are-monitors-equivalent
#12
Alex V Rowlands, Evgeny M Mirkes, Tom Yates, Stacey Clemes, Melanie Davies, Kamlesh Khunti, Charlotte L Edwardson
PURPOSE: Accelerometers are increasingly being used to assess physical activity in large-scale surveys. Establishing whether key physical activity outcomes can be considered equivalent between three widely-used accelerometer brands would be a significant step towards capitalising on the increasing availability of accelerometry data for epidemiological research. METHODS: Twenty participants wore a GENEActiv, Axivity AX3 and ActiGraph GT9X on their non-dominant wrist and were observed for two-hours in a simulated living space...
October 2, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28960131/blood-perfusion-changes-during-sacral-nerve-root-stimulation-versus-surface-gluteus-electrical-stimulation-on-in-seated-spinal-cord-injury
#13
Liang Qin Liu, Martin Ferguson-Pell
The objective of this article is to examine dynamic changes of ischial blood perfusion during sacral nerve root stimulation against surface functional electrical stimulation (FES). Fourteen adults with suprasacral spinal cord injury (SCI) were recruited. The gluteal maximus was activated by surface FES or stimulating sacral nerve roots by functional magnetic stimulation (FMS) or a sacral anterior root stimulator implant (SARS). Ischial skin index of hemoglobin (IHB) and oxygenation (IOX) was measured.Skin blood perfusion was significantly higher during FMS than the baseline (IHB 1...
September 29, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28952156/positive-expiratory-pressure-therapy-versus-other-airway-clearance-techniques-for-bronchiectasis
#14
REVIEW
Annemarie L Lee, Angela T Burge, Anne E Holland
BACKGROUND: People with bronchiectasis experience chronic cough and sputum production and require the prescription of airway clearance techniques (ACTs). A common type of ACT prescribed is positive expiratory pressure (PEP) therapy. A previous review has suggested that ACTs including PEP therapy are beneficial compared to no treatment in people with bronchiectasis. However, the efficacy of PEP therapy in a stable clinical state or during an acute exacerbation compared to other ACTs in bronchiectasis is unknown...
September 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28943154/sex-differences-in-leg-dexterity-are-not-present-in-elite-athletes
#15
Emily L Lawrence, Lorenzo Peppoloni, Francisco J Valero-Cuevas
We studied whether the time-varying forces that control unstable foot-ground interactions provide insight into the neural control of dynamic leg function. Twenty elite (10F, 26.4±3.5yrs) and 20 recreational (10F, 24.8±2.4yrs) athletes used an isolated leg to maximally compress a slender spring designed to buckle at low forces while seated. The foot forces during the compression at the edge of instability quantify the maximal sensorimotor ability to control dynamic foot-ground interactions. Using the nonlinear analysis technique of attractor reconstruction, we characterized the spatial (interquartile range IQR) and geometric (trajectory length TL, volume V, and sum of edge lengths SE) features of the dynamical behavior of those force time series...
October 3, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28918003/relevance-of-adding-a-triangular-dynamic-cushion-on-a-traditional-chair-a-3d-analysis-of-seated-schoolchildren
#16
T Fettweis, M N Onkelinx, C Schwartz, C Demoulin, J L Croisier, M Vanderthommen
BACKGROUND: Low back pain is highly prevalent in the general population and is even reported as early as at primary school. A poor sitting position has been suggested as an etiologic factor. This study analysed, in primary schoolchildren, the influence of a triangular dynamic cushion that aims to help children maintain their physiological lumbar lordosis and to induce movement to reduce the static effect of the sitting position. METHODS: Thirty 8-year-old children took part in this study...
September 8, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28846736/molecular-cloning-and-characterization-of-pirarucu-arapaima-gigas-follicle-stimulating-hormone-and-luteinizing-hormone-%C3%AE-subunit-cdnas
#17
Thais Sevilhano, Roberto Feitosa de Carvalho, Nélio Alessandro de Jesus Oliveira, João Ezequiel Oliveira, Vinicius Gonçalves Maltarollo, Gustavo Trossini, Riviane Garcez, Paolo Bartolini
The common gonadotrophic hormone α-subunit (GTHα) has been previously isolated by our research group from A. gigas pituitaries; in the present work the cDNA sequences encoding FSHβ and LHβ subunits have also been isolated from the same species of fish. The FSH β-subunit consists of 126 amino acids with a putative 18 amino acid signal peptide and a 108 amino acid mature peptide, while the LH β-subunit consists of 141 amino acids with a putative 24 amino acid amino acid signal peptide and a 117 amino acid mature peptide...
2017: PloS One
https://www.readbyqxmd.com/read/28817375/effect-of-maternal-antibody-transfer-on-antibody-dynamics-and-control-of-porcine-circovirus-type-2-infection-in-offspring
#18
Cheryl M T Dvorak, Brian J Payne, Jessica L Seate, Michael P Murtaugh
Sow immunity plays an important role in preventing viral infection and disease in newborn piglets. Vertical transmission of porcine circovirus type 2 (PCV2) may perpetuate porcine circovirus associated disease (PCVAD) in newborn and growing pigs. Hence, the immunological effects of maternal immunoglobulin transfer of PCV2-specific antibodies on PCV2 viremia and immune response in piglets in commercial swine herds were evaluated. Sow vaccination has been shown to reduce viral shedding and viremia, and increases the neutralizing antibody (NA) titers...
August 17, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28780186/dynamic-forces-over-the-interface-between-a-seated-human-body-and-a-rigid-seat-during-vertical-whole-body-vibration
#19
Chi Liu, Yi Qiu, Michael J Griffin
Biodynamic responses of the seated human body are usually measured and modelled assuming a single point of vibration excitation. With vertical vibration excitation, this study investigated how forces are distributed over the body-seat interface. Vertical and fore-and-aft forces were measured beneath the ischial tuberosities, middle thighs, and front thighs of 14 subjects sitting on a rigid flat seat in three postures with different thigh contact while exposed to random vertical vibration at three magnitudes...
July 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28753685/effects-of-lumbar-spine-assemblies-and-body-borne-equipment-mass-on-anthropomorphic-test-device-responses-during-drop-tests
#20
Daniel Aggromito, Mark Jaffrey, Allen Chhor, Bernard Chen, Wenyi Yan
When simulating or conducting land mine blast tests on armored vehicles to assess potential occupant injury, the preference is to use the Hybrid III anthropomorphic test device (ATD). In land blast events, neither the effect of body-borne equipment (BBE) on the ATD response nor the dynamic response index (DRI) is well understood. An experimental study was carried out using a drop tower test rig, with a rigid seat mounted on a carriage table undergoing average accelerations of 161 g and 232 g over 3 ms. A key aspect of the work looked at the various lumbar spine assemblies available for a Hybrid III ATD...
October 1, 2017: Journal of Biomechanical Engineering
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