Daiana C Salm, Verônica V Horewicz, Fernanda Tanaka, Júlia K Ferreira, Bruna H de Oliveira, Julia Maria Batista Maio, Nathalia N Donatello, Daniela D Ludtke, Leidiane Mazzardo-Martins, Aline R Dutra, Josiel M Mack, Deborah de C H Kunzler, Eduardo Cargnin-Ferreira, Afonso S I Salgado, Edsel B Bittencourt, Gianluca Bianco, Anna Paula Piovezan, Franciane Bobinski, Ari O O Moré, Daniel F Martins
This study evaluated the antihyperalgesic and anti-inflammatory effects of percutaneous vagus nerve electrical stimulation (pVNS) by comparing the effects of alternating and random frequencies in an animal model of persistent inflammatory hyperalgesia. The model was induced by Freund's complete adjuvant (CFA) intraplantar (i.pl.) injection. Mice were treated with different protocols of time (10, 20, or 30 min), ear laterality (right, left or both), and frequency (alternating or random). Mechanical hyperalgesia was evaluated, and some groups received i...
February 6, 2023: Molecular Neurobiology