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https://www.readbyqxmd.com/read/30337243/modulation-of-neuroinflammation-and-memory-dysfunction-using-percutaneous-vagus-nerve-stimulation-in-mice
#1
William J Huffman, Saraswathi Subramaniyan, Ramona M Rodriguiz, William C Wetsel, Warren M Grill, Niccolò Terrando
BACKGROUND: The vagus nerve is involved in regulating immunity and resolving inflammation. Current strategies aimed at modulating neuroinflammation and cognitive decline, in many cases, are limited and ineffective. OBJECTIVE: We sought to develop a minimally invasive, targeted, vagus nerve stimulation approach (pVNS), and we tested its efficacy with respect to microglial activation and amelioration of cognitive dysfunction following lipopolysaccharide (LPS) endotoxemia in mice...
October 9, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/30266323/complications-after-total-knee-arthroplasty-in-patients-with-pigmented-villonodular-synovitis
#2
Aaron J Casp, James A Browne, Nicole E Durig, Brian C Werner
BACKGROUND: Pigmented villonodular synovitis (PVNS) is a locally destructive histiocytic proliferation most commonly occurring in the knee. Extensive local joint destruction can indicate the need for a total knee arthroplasty (TKA). The objective of this study is to evaluate PVNS of the knee as a risk factor for complication after TKA. METHODS: Patients who underwent TKA with a diagnosis of PVNS of the knee from 2007 to 2016 were identified in a national private payer insurance database...
September 6, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/30246789/higuchi-fractal-dimension-of-heart-rate-variability-during-percutaneous-auricular-vagus-nerve-stimulation-in-healthy-and-diabetic-subjects
#3
Ryszard S Gomolka, Stefan Kampusch, Eugenijus Kaniusas, Florian Thürk, Jozsef C Széles, Wlodzimierz Klonowski
Analysis of heart rate variability (HRV) can be applied to assess the autonomic nervous system (ANS) sympathetic and parasympathetic activity. Since living systems are non-linear, evaluation of ANS activity is difficult by means of linear methods. We propose to apply the Higuchi fractal dimension (HFD) method for assessment of ANS activity. HFD measures complexity of the HRV signal. We analyzed 45 RR time series of 84 min duration each from nine healthy and five diabetic subjects with clinically confirmed long-term diabetes mellitus type II and with diabetic foot ulcer lasting more than 6 weeks...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30227838/the-predictive-value-of-preoperative-neutrophil-lymphocyte-ratio-nlr-on-the-recurrence-of-the-local-pigmented-villonodular-synovitis-of-the-knee-joint
#4
Guanglei Zhao, Jin Wang, Jun Xia, Yibing Wei, Siqun Wang, Gangyong Huang, Feiyan Chen, Jie Chen, Jingsheng Shi, Yuanqing Yang
BACKGROUND: To explore and evaluate the predictive value of preoperative Neutrophil-lymphocyte ratio (NLR) on the recurrence of pigmented villonodular synovitis (PVNS) of the knee joint treated by arthroscopic surgery combining local radiotherapy. METHODS: Sixty pathological-proven PVNS cases of the knee joint in our department from April 2006 to March 2017 were included. All of them are treated by arthroscopic synovectomy combined with adjuvant radiotherapy. The pre-operative hematological indexes such as c-reactive protein (CRP), erythrocyte sedimentation rate (ESR), NLR, Platelet-lymphocyte ratio (PLR) and Lymphocyte-monocyte ratio (LMR) were collected retrospectively and their relationship with postoperative recurrence was analyzed by using univariate and multivariate analysis, the receiver operating characteristic curves (ROC curve), the Kappa correspondence test and the Mc Nemar Chi-square test...
September 19, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30038543/bilateral-localized-pigmented-villonodular-synovitis-of-the-knee-case-report-and-review
#5
Tiago Lazzaretti Fernandes, Livia Dau Videira, Sandra Umeda Sasaki, Renato José Mendonça Natalino, Adriano Marques DE Almeida, André Pedrinelli, Arnaldo José Hernandez
Objectives: Several cases of bilateral diffuse pigmented villonodular synovitis (PVNS) or tenosynovial giant cell tumor have been described in the literature. Nevertheless, some presentations are rare and differential diagnoses are necessary. Methods: The purpose of this study was to perform a systematic review of the literature related to PVNS and to report a rare supra-patellar bilateral and focal presentation. We performed a systematic data review in the Pubmed Clinical Queries database using MeSH and keywords related to PVNS and tenosynovial giant cell tumor...
May 2018: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/30034899/localized-pigmented-villonodular-synovitis-of-the-posterior-knee-compartment-with-popliteal-vessel-compression-a-case-report-of-arthroscopic-resection-using-only-anterior-knee-portals
#6
Jack Daoud, Dany Aouad, Youssef Hassan, Georges El Rassi
Background: Pigmented villonodular synovitis is a rare pathology causing hyperplasia of the synovium. It mostly affects young populations and most commonly the knee joint. It rarely affects the posterior compartment of the knee as the case presented in this study. Open surgery is usually used to treat this condition; however, in our case it was excised arthroscopically despite the anatomical challenges of the posterior knee compartment. Case Presentation: This case presents a female patient with a complaint of posterior-region pain of her left knee post direct trauma post fall...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/30008053/recombinant-helical-plant-virus-based-nanoparticles-for-vaccination-and-immunotherapy
#7
REVIEW
Kannan Badri Narayanan, Sung Soo Han
Plant virus-based nanoparticles (PVNs) are self-assembled capsid proteins of plant viruses, and can be virus-like nanoparticles (VLPs) or virus nanoparticles (VNPs). Plant viruses showing helical capsid symmetry are used as a versatile platform for the presentation of multiple copies of well-arrayed immunogenic antigens of various disease pathogens. Helical PVNs are non-infectious, biocompatible, and naturally immunogenic, and thus, they are suitable antigen carriers for vaccine production and can trigger humoral and/or cellular immune responses...
July 14, 2018: Virus Genes
https://www.readbyqxmd.com/read/29917011/pigmented-villonodular-synovitis-of-the-knee-an-underappreciated-source-of-pain-in-children-and-adolescents
#8
Samuel Clifton Willimon, Michael T Busch, Crystal A Perkins
BACKGROUND: Pigmented villonodular synovitis (PVNS) is a benign proliferative synovial disorder most commonly described in adults. The purpose of this study is to describe the presentation and management of a large single-center series of pediatric patients with PVNS of the knee. METHODS: A retrospective review was performed of consecutive pediatric patients treated for PVNS at a single institution from 2001 to 2016. Inclusion criteria were patients below 20 years of age with surgical treatment of histologically proven PVNS of the knee...
September 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29864767/computed-tomography-findings-of-pigmented-villonodular-synovitis-in-a-dog
#9
Lara M Dempsey, Thomas W Maddox, Thelma Meiring, Brandan Wustefeld-Janssens, Eithne J Comerford
Pigmented villonodular synovitis (PVNS) is a rare benign and usually monoarticular neoplastic lesion arising from the synovium, bursae and tendon sheaths in humans, horses and dogs. Categorization for PVNS in humans includes localized and diffuse forms of PVNS and tenosynovial giant cell tumour (TGCT), although histologically they are the same. The localized form is characterized by discrete nodular lesions, the diffuse form is often intra-articular, infiltrative, affecting the entire synovium with more aggressive behaviour and TGCT occurs along tendon sheaths...
July 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29727868/arthroscopic-treatment-of-diffuse-pigmented-villonodular-synovitis-of-the-knee-complete-synovectomy-and-septum-removal-midterm-results
#10
Sohrab Keyhani, Seyyed Morteza Kazemi, Jin Hwan Ahn, René Verdonk, Mehran Soleymanha
The purpose of this study was to evaluate and describe the clinical results of complete arthroscopic synovectomy through the four arthroscopic portals in the knees affected by diffuse pigmented villonodular synovitis (DPVNS). Between 2009 and 2012, 21 patients (15 men and 6 women) with the diffuse form of PVNS of the knee were enrolled in the study after qualification. The clinical diagnosis was confirmed by magnetic resonance imaging and postsurgical pathologic examination. All patients underwent complete synovectomy through posteromedial, posterolateral, anteromedial, and anterolateral portals...
May 4, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29700612/pigmented-villonodular-synovitis-managed-by-total-synovectomy-and-cementless-total-hip-arthroplasty
#11
Mohamed Mansour Elzohairy
BACKGROUND: Pigmented villonodular synovitis or PVNS is a benign proliferating disease of the synovium; it behaves much as a neoplastic process does. METHODS: This retrospective clinical study included 11 consecutive cases who underwent for total synovectomy combined with cementless total hip arthroplasty of PVNS of the hip joint. RESULTS: The mean patient preoperative hip score of Harris was 46.1 points (range 30-70 points) improved to 94...
October 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29594178/arthroscopic-management-of-pigmented-villonodular-synovitis-of-the-hip-in-children-and-adolescents
#12
S Clifton Willimon, Tim Schrader, Crystal A Perkins
Background: Pigmented villonodular synovitis (PVNS) is a benign proliferative synovial disorder most commonly described to affect the knee in adults. Literature describing PVNS in the pediatric population is limited to 2 small case series and a handful of single-patient case reports. Within these studies, only 2 patients with PVNS of the hip are described. Purpose: To describe the presentation, management, and outcomes of a single-center series of pediatric patients with PVNS of the hip treated with arthroscopic synovectomy...
March 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29580718/burden-of-illness-associated-with-tenosynovial-giant-cell-tumors
#13
Tanya M Burton, Xin Ye, Emily D Parker, Tim Bancroft, John Healey
PURPOSE: Little is known about the burden of illness in patients with tenosynovial giant cell tumors (TGCT), which are rare, typically benign, lesions of the synovial tissue including giant cell tumor of the tendon sheath (GCT-TS) and pigmented villonodular synovitis (PVNS). The objective of this study was to describe health care resource use and costs for patients with GCT-TS and PVNS, which are rare and typically benign TGCT. METHODS: A retrospective cohort study design was used to analyze administrative claims for adult commercial and Medicare Advantage health plan enrollees with evidence of GCT-TS and PVNS from January 1, 2006 through March 31, 2015...
April 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29549822/social-norms-and-women-s-risk-of-intimate-partner-violence-in-nepal
#14
Cari Jo Clark, Gemma Ferguson, Binita Shrestha, Prabin Nanicha Shrestha, J Michael Oakes, Jhumka Gupta, Susi McGhee, Yuk Fai Cheong, Kathryn M Yount
Social norms increasingly are the focus of intimate partner violence (IPV) prevention strategies but are among the least examined contextual factors in quantitative violence research. This study assesses the within-community, between-community, and contextual effect of a new measure of social norms (PVNS: Partner Violence Norms Scale) on women's risk of IPV. Data come from baseline surveys collected from 1435 female, married, reproductive-age participants, residing in 72 wards in three districts (Chitwan, Kapilvastu, Nawalparasi) in Nepal who were enrolled in a cluster randomized trial testing the impact of a social behavioral change communication intervention designed to prevent IPV...
April 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29507590/electroacupuncture-improved-the-function-of-myocardial-ischemia-involved-in-the-hippocampus-paraventricular-nucleus-sympathetic-nerve-pathway
#15
Shuai Cui, Yiping Zhou, Shengbing Wu, Jian Cao, Guoqi Zhu, Meiqi Zhou
We investigated the hippocampus-paraventricular nucleus- (PVN-) sympathetic nerve pathway in electroacupuncture (EA) at the heart meridian for the treatment of myocardial ischemia by observing PVN neuronal discharge, sympathetic nerve discharge, and hemodynamics parameters. Sprague Dawley (SD) rats were equally divided into four groups: Sham, Model, Model + EA, and Model + EA + Lesion. The model rat was established by ligating the left anterior descending branch of the coronary artery. Changes in the sympathetic nerve discharge and hemodynamic parameters were observed...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29504995/necessity-of-adjuvant-postoperative-radiotherapy-for-diffuse-pigmented-villonodular-synovitis-of-the-knee-a-case-report-and-literature-review
#16
REVIEW
Yanfang Duan, Jing Qian, Kun Chen, Zhuo Zhang
RATIONALE: Pigmented villonodular synovitis (PVNS) is an idiopathic, proliferative disorder lesion of synovial tissue, which is regarded as a benign disease, but has a local invasion. Up to now, these are no consensus about the etiology and pathogenesis of PVNS. Because of the lack of typical clinical features, misdiagnosis and delayed diagnosis are not uncommon, magnetic resonance imaging (MRI) can assist diagnosis and histopathological examination is recognized as the gold standard for the final diagnosis...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29475829/the-patient-perspective-on-the-impact-of-tenosynovial-giant-cell-tumors-on-daily-living-crowdsourcing-study-on-physical-function-and-quality-of-life
#17
Monique Josephine Mastboom, Rosa Planje, Michiel Adreanus van de Sande
BACKGROUND: Tenosynovial giant cell tumor (TGCT) is a rare, benign lesion affecting the synovial lining of joints, bursae, and tendon sheaths. It is generally characterized as a locally aggressive and often recurring tumor. A distinction is made between localized- and diffuse-type. The impact of TGCT on daily living is currently ill-described. OBJECTIVE: The aim of this crowdsourcing study was to evaluate the impact of TGCT on physical function, daily activities, societal participation (work, sports, and hobbies), and overall quality of life from a patient perspective...
February 23, 2018: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/29354472/systematic-arthroscopic-treatment-of-diffuse-pigmented-villonodular-synovitis-in-the-knee
#18
Justin S Chang, James P Higgins, Jonathan D Kosy, John Theodoropoulos
Pigmented villonodular synovitis (PVNS) is a benign aggressive disease that presents in either a localized (LPVNS) or diffuse (DPVNS) form. Arthroscopic synovectomy is the standard operative treatment for LPVNS, and when used to treat DPVNS, it is usually combined with an open posterior procedure. The purpose of this Technical Note is to report the technique that we have refined to allow for arthroscopic synovectomy as the sole treatment for DPVNS. We describe our technique with the factors we have found to be important to ensure adequate arthroscopic synovectomy, while minimizing risks and complications...
October 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29352684/long-term-outcome-of-hip-arthroplasty-in-the-setting-of-pigmented-villonodular-synovitis
#19
Meagan E Tibbo, Cody C Wyles, Peter S Rose, Franklin H Sim, Matthew T Houdek, Michael J Taunton
BACKGROUND: Pigmented villonodular synovitis (PVNS) is a rare, benign, painful proliferation of the synovium previously treated successfully with total hip arthroplasty (THA). Published results come from small series; therefore, the purpose of this study is to investigate the outcomes of THA in the setting of PVNS. METHODS: We identified 25 patients with histologically confirmed, diffuse PVNS who underwent THA between 1971 and 2013. Mean follow-up and age was 10 years and 39 years...
May 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29343257/pigmented-villonodular-synovitis-in-pediatric-population-review-of-literature-and-a-case-report
#20
REVIEW
Mohsen Karami, Mehryar Soleimani, Reza Shiari
BACKGROUND: Pigmented villonodular synovitis (PVNS) is a rare proliferative process in children that mostly affects the knee joint. CASE PRESENTATION: The study follows the case of a 3-year-old boy presenting recurrent patellar dislocation and PVNS. Due to symptoms such as chronic arthritis, he had been taking prednisolone and methotrexate for 6 months before receiving a definitive diagnosis. After a period of showing no improvements from his treatment, he was referred to our center and was diagnosed with local PVNS using magnetic resonance imaging (MRI)...
January 17, 2018: Pediatric Rheumatology Online Journal
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