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https://www.readbyqxmd.com/read/29282525/long-term-outcome-of-pigmented-villonodular-synovitis-of-the-hip-after-joint-preserving-therapy
#1
Martin Hufeland, Markus Gesslein, Carsten Perka, Jörg Hartmut Schröder
INTRODUCTION: Pigmented villonodular synovitis (PVNS) is a rare, destructive synovial disease that affects the hip joint the second most common after the knee. However, in contrast, joint preserving surgery in the hip joint is considered to be significantly more difficult or even impossible due to earlier occurrence of osteochondral dissemination and surgical difficulties. Today, earlier diagnosis due to the generous use of MRI and modern surgical strategies raise hope for improved outcomes...
December 27, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29220303/locally-aggressive-connective-tissue-tumors
#2
Mrinal M Gounder, David M Thomas, William D Tap
In this review, we highlight the complexities of the natural history, biology, and clinical management of three intermediate connective tissue tumors: desmoid tumor (DT) or aggressive fibromatosis, tenosynovial giant cell tumor (TGCT) or diffuse-type pigmented villonodular synovitis (dtPVNS), and giant cell tumor of bone (GCTB). Intermediate histologies include tumors of both soft tissue and bone origin and are locally aggressive and rarely metastatic. Some common aspects to these tumors are that they can be locally infiltrative and/or impinge on critical organs, which leads to disfigurement, pain, loss of function and mobility, neurovascular compromise, and occasionally life-threatening consequences, such as mesenteric, bowel, ureteral, and/or bladder obstruction...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29218093/p2x7-receptor-regulates-sympathoexcitatory-response-in-myocardial-infarction-rats-via-nf-%C3%AE%C2%BAb-and-mapk-pathways
#3
Qin Wu, Hongtao Xu, Ling Hao, Guifang Ma, Jinxia Sun, Xianghe Song, Fengyun Ding, Nan Wang
Previous studies have provided evidence for the regulatory effect of P2X7 receptor (P2X7R) on cardiovascular activities. Our study focused on exploring the function and fundamental mechanism of microglial P2X7R in controlling sympathoexcitatory response using rats with acute myocardial infarction (AMI). Coronary artery ligation was used in rats to cause AMI. And before that, rats were administrated with P2X7R siRNA that targeted P2X7R mRNA into paraventricular nucleus (PVN) or BBG (Brilliant Blue G, a P2X7 receptor antagonist)...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29215692/chondroid-tenosynovial-giant-cell-tumor-of-the-temporomandibular-joint-a-rare-case-report
#4
Ana Lia Anbinder, Barbara Maria Corrêa Geraldo, Rubens Guimarães, Débora Lima Pereira, Oslei Paes de Almeida, Yasmin Rodarte Carvalho
Tenosynovial giant cell tumor of diffuse type (TGCT-d) or pigmented villonodular synovitis (PVNS) is a locally aggressive lesion that mostly affects the joints of long bones. Chondroid tenosynovial giant cell tumor (CTGCT) or PVNS with chondroid metaplasia is a rare distinct subset of synovial tumors that has a predilection for the TMJ. We report a rare case of CTGCT in the TMJ, initially misdiagnosed as temporomandibular disorder (TMD). A 51-year-old woman was referred to the surgeon with the chief complaint of TMJ pain for 5 years and a past history of an unsuccessful TMD treatment...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29209178/a-three-layer-network-model-of-direction-selective-circuits-in-the-optic-tectum
#5
Fatima Abbas, Marcus A Triplett, Geoffrey J Goodhill, Martin P Meyer
The circuit mechanisms that give rise to direction selectivity in the retina have been studied extensively but how direction selectivity is established in retinorecipient areas of the brain is less well understood. Using functional imaging in larval zebrafish we examine how the direction of motion is encoded by populations of neurons at three layers of the optic tectum; retinal ganglion cell axons (RGCs), a layer of superficial inhibitory interneurons (SINs), and periventricular neurons (PVNs), which constitute the majority of neurons in the tectum...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29202997/arthroscopic-treatment-of-intra-artricularly-localised-pigmented-villonodular-synovitis-of-the-ankle-4-cases-with-long-term-follow-up
#6
Ulunay Kanatli, M Baybars Ataoğlu, Mustafa Özer, Ahmet Yildirim, Mehmet Cetinkaya
BACKGROUND CONTEXT: Pigmented villonodular synovitis (PVNS) is a rare, locally aggressive benign proliferative pathology of synovial tissue. Lesions are classified regarding location as diffuse or localised which are same as histologically. Intra-articularly localised type is relatively rare, especially in the ankle joint. Because of the high recurrence rate and aggressive nature, localised lesions should be excised totally. PURPOSE: We performed a retrospective study of 4 patients with intra-articularly localised PVNS in the ankle joint who were treated by total arthroscopic excision and evaluated for functional results and recurrence rate...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28978573/a-rare-case-of-localised-pigmented-villonodular-synovitis-in-the-knee-of-a-24-year-old-female-soccer-player-diagnosis-management-and-summary-of-tenosynovial-giant-cell-tumours
#7
Casper Falster, Simon Stockmann Poulsen, Uffe Joergensen
Localised pigmented villonodular synovitis (PVNS) of the knee is a rare diagnosis, with clinical signs and symptoms mimicking meniscal damage or other common knee injuries.We report the case of a 24-year-old female soccer player, seeking treatment after 7 months of persisting knee pain. Additionally, we present an overview of tenosynovial giant cell tumours.On examination, the patient was found to have tenderness in the medial joint space of the knee. MRI revealed a heterogeneous formation in the central part of the knee...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28952882/pharmacokinetics-and-efficacy-of-doxorubicin-loaded-plant-virus-nanoparticles-in-preclinical-models-of-cancer
#8
Andrew J Madden, Bruce Oberhardt, Dustin Lockney, Charlene Santos, Preethi Vennam, David Arney, Stefan Franzen, Steven A Lommel, C Ryan Miller, Paola Gehrig, William C Zamboni
AIM: To compare the pharmacokinetics and efficacy of doxorubicin containing plant virus nanoparticles (PVNs) with PEGylated liposomal doxorubicin (PLD) and small molecule doxorubicin in two mouse models of cancer. MATERIALS & METHODS: Studies were performed in A375 melanoma and intraperitoneal SKOV3ip1 ovarian cancer xenografts. The PVNs were administered in lower and more frequent doses in the ovarian model. RESULTS: The PVNs were more efficacious than PLD and small molecule doxorubicin in the ovarian cancer model, but not in the melanoma cancer model...
September 27, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28875266/csf-1r-inhibitor-development-current-clinical-status
#9
REVIEW
Florent Peyraud, Sophie Cousin, Antoine Italiano
PURPOSE OF REVIEW: Colony-stimulating factor 1 receptor (CSF-1R) and its ligands, CSF-1 and interleukin 34 (IL-34), regulate the function and survival of tumor-associated macrophages, which are involved in tumorigenesis and in the suppression of antitumor immunity. Moreover, the CSF-1R/CSF-1 axis has been implicated in the pathogenesis of pigmented villonodular synovitis (PVNS), a benign tumor of the synovium. As advanced or metastatic malignant solid tumors and relapsed/refractory PVNS remain unresolved therapeutic problems, new approaches are needed to improve the outcome of patients with these conditions...
September 5, 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28840659/violence-exposure-and-resulting-psychological-effects-suffered-by-psychiatric-visiting-nurses-in-japan
#10
H Fujimoto, M Hirota, T Kodama, C Greiner, T Hashimoto
WHAT IS KNOWN ON THE SUBJECT?: There is a developing body of research on violence in healthcare workplaces. Although psychiatric visiting nurses (PVNs) are an important group of professionals who provide medical services for people with mental disorders live in the community, little is known about the experiences and characteristics of violence exposure among PVNs, or the characteristics and work situations of PVNs related to violence exposure. WHAT THIS STUDY ADDS TO EXISTING KNOWLEDGE?: Approximately 40% of participants were exposed to violence during the previous 12 months; approximately 50% had been exposed during their PVN careers in PVN settings...
August 24, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28776631/diffuse-pigmented-villonodular-synovitis-as-a-rare-cause-of-graft-failure-following-anterior-cruciate-ligament-reconstruction
#11
Rajiv Rajani, Liliana Ogden, Christopher J Matthews, C Parker Gibbs
This case report describes a 42-year-old woman who was diagnosed with pigmented villonodular synovitis (PVNS) in the knee. The patient had received a bone-patella tendon-bone autograft reconstruction of her anterior cruciate ligament (ACL) 22 years prior to her diagnosis of PVNS. After a traumatic event that tore her ACL graft, she underwent a second surgery to repair the initial reconstruction. However, her pain and joint instability remained unresolved. When radiolucent lesions in her tibia and femur were identified through a radiographic image, the patient was referred to the authors' orthopedic oncology clinic...
August 3, 2017: Orthopedics
https://www.readbyqxmd.com/read/28764182/pigmented-villonodular-synovitis-of-thumb-a-cytological-diagnosis
#12
Kaneeka Bhatnagar, Akshdeep Singh Bawa, Vikram Narang, Pavneet Kaur
Pigmented Villonodular Synovitis (PVNS) is a unique benign proliferative process of unknown aetiology involving the synovial lined joints diffusely or focally. The entity remains a diagnostic challenge. This condition is attributed to an increased synovial proliferation causing villous or nodular changes of synovial lined joints leading to PVNS, Pigmented Villonodular Bursitis (PVNB) when arising from bursae or Pigmented Villonodular Tenosynovitis (PVNTS) originating from the tendon sheath. We present a case of a young female with nodular masses on right thumb with cytomorphological features on FNAC suggestive of PVNS which was finally confirmed by histopathology...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28749260/pigmented-villonodular-synovitis-in-a-reticulated-giraffe-giraffa-camelopardalis
#13
Elizabeth A Ihms, Anne Rivas, Ellen Bronson, Lisa M Mangus
: A 17-yr-old, female, captive-born reticulated giraffe ( Giraffa camelopardalis ) presented with acute-onset lameness of the right metacarpophalangeal (fetlock) joint. Despite multiple courses of treatment, the lameness and swelling progressively worsened over a 3.5-yr period, and the giraffe was euthanized. At necropsy, gross and microscopic changes in the right, front fetlock and associated flexor tendon sheath included villous synovial hyperplasia and the formation of discrete pigmented nodules within synovial membranes...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28741329/-localized-pigmented-vellonodular-sunovitis-cause-of-knee-hemarthrosis
#14
F J Martínez-Ruiz, A Salaverry-Walls, M Bautista-Morales, C Rivera-Reyes, J G Montero-García
The pigmented vellonodular sinovitis (PVNS) is benign neoplasm with synovial proliferation and hemosiderin deposit, characterized by large compromising joints, especially the knee. At present, two variants of clinics, the diffuse form (PVNSD) and the localized (PVNSL) are described. Arthroscopic synovectomy and radiosynoviorthesis (RSO) is the treatment that has shown the best functional results. Nuclear magnetic resonance is an appropriate method for conducting the diagnosis of PVNSL.
January 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28728303/-enhancing-soft-tissue-reattachment-with-artificial-mesh-in-joint-endoprosthetic-reconstruction-for-bone-tumors
#15
J S Lin, R Chen, W Yan, D D Chen
Objective: To investigate the operative method and clinical application of the BARD(®) Mesh in enhancing joint stability and function of endoprosthetic reconstruction for bone tumors. Methods: From Jan 2013 to Jun 2015, the clinical data of 51 patients aged (44.75±23.18) years underwent wide resection of tumor and endoprosthetic reconstruction using the BARD(®) Mesh were collected. Among them, 27 were male and 24 were female. The surgical treatments received by these patients included 5 shoulder arthroplasties, 12 elbow replacements, 12 hip replacements and 32 knee replacements (including 24 femoral tumors and 8 tibial tumors)...
July 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28683727/multifocal-pigmented-villonodular-synovitis-coexisting-in-both-the-knee-joint-and-the-patella-a-case-report-and-literature-review
#16
Mingxuan Gao, Hong Li, Xiaoyan Liang, Xiaoyan Fu, Xusheng Li
BACKGROUD: Pigmented villonodular synovitis (PVNS) is an uncommon entity of proliferative lesion of the synovium, presenting with different clinical signs and symptoms. PVNS rarely forms an osteolytic lesion in a bone. Here we report a unique case of PVNS with a nodular lesion in the left patella. CASE PRESENTATION: A 37-year-old female was referred to our hospital with complaints of ongoing left knee pain and a painful and palpable mass in her left popliteal fossa...
July 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28663570/brain-stimulation-in-obesity
#17
REVIEW
C H Göbel, V M Tronnier, T F Münte
Obesity is taking up epidemic proportions worldwide with significant impacts on the health of both the affected individual and on society as a whole. Treatment approaches consist of behavioural and pharmacological approaches, however, these are often found to be ineffective. In severe obesity, bariatric surgery is frequently performed. Unfortunately, 40% of patients show substantial weight gain over the long term or display the associated metabolic syndrome, making the development of novel therapies necessary...
June 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28638690/an-unusual-case-of-diffuse-pigmented-villonodular-synovitis-of-the-shoulder-a-multidisciplinary-approach-with-arthroscopic-synovectomy-and-adjuvant-radiotherapy
#18
Tânia Quinás Serra, João Morais, Zico Gonçalves, Francisco Agostinho, Gilberto Melo, Mónica Henriques
Pigmented villonodular synovitis (PVNS) is a rare proliferative disorder of the synovial membrane. This condition is usually monoarticular, can be locally destructive, and involves muscles, tendons, bursae, bones, and skin. The most commonly affected joints are the knee and hip, followed by the ankle and shoulder. Patients often present with pain, swelling, and joint effusion; however, the duration of symptoms varies. Total synovectomy is the preferred treatment for PVNS. Subtotal synovectomy is a factor of recurrence, and in diffuse PVNS, total excision is very difficult to achieve...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28552192/long-term-outcome-of-knee-arthroplasty-in-the-setting-of-pigmented-villonodular-synovitis
#19
Matthew T Houdek, Maurizio Scorianz, Cody C Wyles, Robert T Trousdale, Franklin H Sim, Michael J Taunton
BACKGROUND: Pigmented villonodular synovitis (PVNS) is a rare, benign proliferation of the synovium, commonly affecting the knee. Arthroplasty can successfully manage arthrosis in this population; however, outcome data is limited. The purpose of this study was to investigate the oncologic and functional outcome of patients undergoing total knee arthroplasty (TKA) in the setting of PVNS. METHODS: 48 patients were identified at our institution with histologically confirmed PVNS that subsequently received TKA...
May 25, 2017: Knee
https://www.readbyqxmd.com/read/28461957/pigmented-villonodular-synovitis-of-the-hip
#20
Sylvain Steinmetz, Anne-Laure Rougemont, Robin Peter
Pigmented villonodular synovitis (PVNS) is a rare disease that can affect any joint, bursa or tendon sheath.The hip is less frequently affected than the knee, and hence is less discussed in scientific journals.PVNS of the hip mainly occurs in young adults, requiring early diagnosis and adequate treatment to obtain good results.There is no consensus on the management of PVNS of the hip in current literature.We will discuss the options for surgical intervention in hip PVNS using a literature review of clinical, biological, etiological, histological and radiographic aspects of the disease...
June 2016: EFORT Open Reviews
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