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https://www.readbyqxmd.com/read/29727868/arthroscopic-treatment-of-diffuse-pigmented-villonodular-synovitis-of-the-knee-complete-synovectomy-and-septum-removal-midterm-results
#1
Sohrab Keyhani, Seyyed Morteza Kazemi, Jin Hwan Ahn, René Verdonk, Mehran Soleymanha
The purpose of this study was to evaluate and describe the clinical results of complete arthroscopic synovectomy through the four arthroscopic portals in the knees affected by diffuse pigmented villonodular synovitis (DPVNS). Between 2009 and 2012, 21 patients (15 men and 6 women) with the diffuse form of PVNS of the knee were enrolled in the study after qualification. The clinical diagnosis was confirmed by magnetic resonance imaging and postsurgical pathologic examination. All patients underwent complete synovectomy through posteromedial, posterolateral, anteromedial, and anterolateral portals...
May 4, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29700612/pigmented-villonodular-synovitis-managed-by-total-synovectomy-and-cementless-total-hip-arthroplasty
#2
Mohamed Mansour Elzohairy
BACKGROUND: Pigmented villonodular synovitis or PVNS is a benign proliferating disease of the synovium; it behaves much as a neoplastic process does. METHODS: This retrospective clinical study included 11 consecutive cases who underwent for total synovectomy combined with cementless total hip arthroplasty of PVNS of the hip joint. RESULTS: The mean patient preoperative hip score of Harris was 46.1 points (range 30-70 points) improved to 94...
April 26, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29594178/arthroscopic-management-of-pigmented-villonodular-synovitis-of-the-hip-in-children-and-adolescents
#3
S Clifton Willimon, Tim Schrader, Crystal A Perkins
Background: Pigmented villonodular synovitis (PVNS) is a benign proliferative synovial disorder most commonly described to affect the knee in adults. Literature describing PVNS in the pediatric population is limited to 2 small case series and a handful of single-patient case reports. Within these studies, only 2 patients with PVNS of the hip are described. Purpose: To describe the presentation, management, and outcomes of a single-center series of pediatric patients with PVNS of the hip treated with arthroscopic synovectomy...
March 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29580718/burden-of-illness-associated-with-tenosynovial-giant-cell-tumors
#4
Tanya M Burton, Xin Ye, Emily D Parker, Tim Bancroft, John Healey
PURPOSE: Little is known about the burden of illness in patients with tenosynovial giant cell tumors (TGCT), which are rare, typically benign, lesions of the synovial tissue including giant cell tumor of the tendon sheath (GCT-TS) and pigmented villonodular synovitis (PVNS). The objective of this study was to describe health care resource use and costs for patients with GCT-TS and PVNS, which are rare and typically benign TGCT. METHODS: A retrospective cohort study design was used to analyze administrative claims for adult commercial and Medicare Advantage health plan enrollees with evidence of GCT-TS and PVNS from January 1, 2006 through March 31, 2015...
April 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29549822/social-norms-and-women-s-risk-of-intimate-partner-violence-in-nepal
#5
Cari Jo Clark, Gemma Ferguson, Binita Shrestha, Prabin Nanicha Shrestha, J Michael Oakes, Jhumka Gupta, Susi McGhee, Yuk Fai Cheong, Kathryn M Yount
Social norms increasingly are the focus of intimate partner violence (IPV) prevention strategies but are among the least examined contextual factors in quantitative violence research. This study assesses the within-community, between-community, and contextual effect of a new measure of social norms (PVNS: Partner Violence Norms Scale) on women's risk of IPV. Data come from baseline surveys collected from 1435 female, married, reproductive-age participants, residing in 72 wards in three districts (Chitwan, Kapilvastu, Nawalparasi) in Nepal who were enrolled in a cluster randomized trial testing the impact of a social behavioral change communication intervention designed to prevent IPV...
April 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29507590/electroacupuncture-improved-the-function-of-myocardial-ischemia-involved-in-the-hippocampus-paraventricular-nucleus-sympathetic-nerve-pathway
#6
Shuai Cui, Yiping Zhou, Shengbing Wu, Jian Cao, Guoqi Zhu, Meiqi Zhou
We investigated the hippocampus-paraventricular nucleus- (PVN-) sympathetic nerve pathway in electroacupuncture (EA) at the heart meridian for the treatment of myocardial ischemia by observing PVN neuronal discharge, sympathetic nerve discharge, and hemodynamics parameters. Sprague Dawley (SD) rats were equally divided into four groups: Sham, Model, Model + EA, and Model + EA + Lesion. The model rat was established by ligating the left anterior descending branch of the coronary artery. Changes in the sympathetic nerve discharge and hemodynamic parameters were observed...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29504995/necessity-of-adjuvant-postoperative-radiotherapy-for-diffuse-pigmented-villonodular-synovitis-of-the-knee-a-case-report-and-literature-review
#7
REVIEW
Yanfang Duan, Jing Qian, Kun Chen, Zhuo Zhang
RATIONALE: Pigmented villonodular synovitis (PVNS) is an idiopathic, proliferative disorder lesion of synovial tissue, which is regarded as a benign disease, but has a local invasion. Up to now, these are no consensus about the etiology and pathogenesis of PVNS. Because of the lack of typical clinical features, misdiagnosis and delayed diagnosis are not uncommon, magnetic resonance imaging (MRI) can assist diagnosis and histopathological examination is recognized as the gold standard for the final diagnosis...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29475829/the-patient-perspective-on-the-impact-of-tenosynovial-giant-cell-tumors-on-daily-living-crowdsourcing-study-on-physical-function-and-quality-of-life
#8
Monique Josephine Mastboom, Rosa Planje, Michiel Adreanus van de Sande
BACKGROUND: Tenosynovial giant cell tumor (TGCT) is a rare, benign lesion affecting the synovial lining of joints, bursae, and tendon sheaths. It is generally characterized as a locally aggressive and often recurring tumor. A distinction is made between localized- and diffuse-type. The impact of TGCT on daily living is currently ill-described. OBJECTIVE: The aim of this crowdsourcing study was to evaluate the impact of TGCT on physical function, daily activities, societal participation (work, sports, and hobbies), and overall quality of life from a patient perspective...
February 23, 2018: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/29354472/systematic-arthroscopic-treatment-of-diffuse-pigmented-villonodular-synovitis-in-the-knee
#9
Justin S Chang, James P Higgins, Jonathan D Kosy, John Theodoropoulos
Pigmented villonodular synovitis (PVNS) is a benign aggressive disease that presents in either a localized (LPVNS) or diffuse (DPVNS) form. Arthroscopic synovectomy is the standard operative treatment for LPVNS, and when used to treat DPVNS, it is usually combined with an open posterior procedure. The purpose of this Technical Note is to report the technique that we have refined to allow for arthroscopic synovectomy as the sole treatment for DPVNS. We describe our technique with the factors we have found to be important to ensure adequate arthroscopic synovectomy, while minimizing risks and complications...
October 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29352684/long-term-outcome-of-hip-arthroplasty-in-the-setting-of-pigmented-villonodular-synovitis
#10
Meagan E Tibbo, Cody C Wyles, Peter S Rose, Franklin H Sim, Matthew T Houdek, Michael J Taunton
BACKGROUND: Pigmented villonodular synovitis (PVNS) is a rare, benign, painful proliferation of the synovium previously treated successfully with total hip arthroplasty (THA). Published results come from small series; therefore, the purpose of this study is to investigate the outcomes of THA in the setting of PVNS. METHODS: We identified 25 patients with histologically confirmed, diffuse PVNS who underwent THA between 1971 and 2013. Mean follow-up and age was 10 years and 39 years...
December 29, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29343257/pigmented-villonodular-synovitis-in-pediatric-population-review-of-literature-and-a-case-report
#11
Mohsen Karami, Mehryar Soleimani, Reza Shiari
BACKGROUND: Pigmented villonodular synovitis (PVNS) is a rare proliferative process in children that mostly affects the knee joint. CASE PRESENTATION: The study follows the case of a 3-year-old boy presenting recurrent patellar dislocation and PVNS. Due to symptoms such as chronic arthritis, he had been taking prednisolone and methotrexate for 6 months before receiving a definitive diagnosis. After a period of showing no improvements from his treatment, he was referred to our center and was diagnosed with local PVNS using magnetic resonance imaging (MRI)...
January 17, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29282525/long-term-outcome-of-pigmented-villonodular-synovitis-of-the-hip-after-joint-preserving-therapy
#12
Martin Hufeland, Markus Gesslein, Carsten Perka, Jörg Hartmut Schröder
INTRODUCTION: Pigmented villonodular synovitis (PVNS) is a rare, destructive synovial disease that affects the hip joint the second most common after the knee. However, in contrast, joint preserving surgery in the hip joint is considered to be significantly more difficult or even impossible due to earlier occurrence of osteochondral dissemination and surgical difficulties. Today, earlier diagnosis due to the generous use of MRI and modern surgical strategies raise hope for improved outcomes...
April 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29220303/locally-aggressive-connective-tissue-tumors
#13
Mrinal M Gounder, David M Thomas, William D Tap
In this review, we highlight the complexities of the natural history, biology, and clinical management of three intermediate connective tissue tumors: desmoid tumor (DT) or aggressive fibromatosis, tenosynovial giant cell tumor (TGCT) or diffuse-type pigmented villonodular synovitis (dtPVNS), and giant cell tumor of bone (GCTB). Intermediate histologies include tumors of both soft tissue and bone origin and are locally aggressive and rarely metastatic. Some common aspects to these tumors are that they can be locally infiltrative and/or impinge on critical organs, which leads to disfigurement, pain, loss of function and mobility, neurovascular compromise, and occasionally life-threatening consequences, such as mesenteric, bowel, ureteral, and/or bladder obstruction...
January 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29218093/p2x7-receptor-regulates-sympathoexcitatory-response-in-myocardial-infarction-rats-via-nf-%C3%AE%C2%BAb-and-mapk-pathways
#14
Qin Wu, Hongtao Xu, Ling Hao, Guifang Ma, Jinxia Sun, Xianghe Song, Fengyun Ding, Nan Wang
Previous studies have provided evidence for the regulatory effect of P2X7 receptor (P2X7R) on cardiovascular activities. Our study focused on exploring the function and fundamental mechanism of microglial P2X7R in controlling sympathoexcitatory response using rats with acute myocardial infarction (AMI). Coronary artery ligation was used in rats to cause AMI. And before that, rats were administrated with P2X7R siRNA that targeted P2X7R mRNA into paraventricular nucleus (PVN) or BBG (Brilliant Blue G, a P2X7 receptor antagonist)...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29215692/chondroid-tenosynovial-giant-cell-tumor-of-the-temporomandibular-joint-a-rare-case-report
#15
Ana Lia Anbinder, Barbara Maria Corrêa Geraldo, Rubens Guimarães, Débora Lima Pereira, Oslei Paes de Almeida, Yasmin Rodarte Carvalho
Tenosynovial giant cell tumor of diffuse type (TGCT-d) or pigmented villonodular synovitis (PVNS) is a locally aggressive lesion that mostly affects the joints of long bones. Chondroid tenosynovial giant cell tumor (CTGCT) or PVNS with chondroid metaplasia is a rare distinct subset of synovial tumors that has a predilection for the TMJ. We report a rare case of CTGCT in the TMJ, initially misdiagnosed as temporomandibular disorder (TMD). A 51-year-old woman was referred to the surgeon with the chief complaint of TMJ pain for 5 years and a past history of an unsuccessful TMD treatment...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29209178/a-three-layer-network-model-of-direction-selective-circuits-in-the-optic-tectum
#16
Fatima Abbas, Marcus A Triplett, Geoffrey J Goodhill, Martin P Meyer
The circuit mechanisms that give rise to direction selectivity in the retina have been studied extensively but how direction selectivity is established in retinorecipient areas of the brain is less well understood. Using functional imaging in larval zebrafish we examine how the direction of motion is encoded by populations of neurons at three layers of the optic tectum; retinal ganglion cell axons (RGCs), a layer of superficial inhibitory interneurons (SINs), and periventricular neurons (PVNs), which constitute the majority of neurons in the tectum...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29202997/arthroscopic-treatment-of-intra-artricularly-localised-pigmented-villonodular-synovitis-of-the-ankle-4-cases-with-long-term-follow-up
#17
Ulunay Kanatli, M Baybars Ataoğlu, Mustafa Özer, Ahmet Yildirim, Mehmet Cetinkaya
BACKGROUND CONTEXT: Pigmented villonodular synovitis (PVNS) is a rare, locally aggressive benign proliferative pathology of synovial tissue. Lesions are classified regarding location as diffuse or localised which are same as histologically. Intra-articularly localised type is relatively rare, especially in the ankle joint. Because of the high recurrence rate and aggressive nature, localised lesions should be excised totally. PURPOSE: We performed a retrospective study of 4 patients with intra-articularly localised PVNS in the ankle joint who were treated by total arthroscopic excision and evaluated for functional results and recurrence rate...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28978573/a-rare-case-of-localised-pigmented-villonodular-synovitis-in-the-knee-of-a-24-year-old-female-soccer-player-diagnosis-management-and-summary-of-tenosynovial-giant-cell-tumours
#18
Casper Falster, Simon Stockmann Poulsen, Uffe Joergensen
Localised pigmented villonodular synovitis (PVNS) of the knee is a rare diagnosis, with clinical signs and symptoms mimicking meniscal damage or other common knee injuries.We report the case of a 24-year-old female soccer player, seeking treatment after 7 months of persisting knee pain. Additionally, we present an overview of tenosynovial giant cell tumours.On examination, the patient was found to have tenderness in the medial joint space of the knee. MRI revealed a heterogeneous formation in the central part of the knee...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28952882/pharmacokinetics-and-efficacy-of-doxorubicin-loaded-plant-virus-nanoparticles-in-preclinical-models-of-cancer
#19
Andrew J Madden, Bruce Oberhardt, Dustin Lockney, Charlene Santos, Preethi Vennam, David Arney, Stefan Franzen, Steven A Lommel, C Ryan Miller, Paola Gehrig, William C Zamboni
AIM: To compare the pharmacokinetics and efficacy of doxorubicin containing plant virus nanoparticles (PVNs) with PEGylated liposomal doxorubicin (PLD) and small molecule doxorubicin in two mouse models of cancer. MATERIALS & METHODS: Studies were performed in A375 melanoma and intraperitoneal SKOV3ip1 ovarian cancer xenografts. The PVNs were administered in lower and more frequent doses in the ovarian model. RESULTS: The PVNs were more efficacious than PLD and small molecule doxorubicin in the ovarian cancer model, but not in the melanoma cancer model...
September 27, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28875266/csf-1r-inhibitor-development-current-clinical-status
#20
REVIEW
Florent Peyraud, Sophie Cousin, Antoine Italiano
PURPOSE OF REVIEW: Colony-stimulating factor 1 receptor (CSF-1R) and its ligands, CSF-1 and interleukin 34 (IL-34), regulate the function and survival of tumor-associated macrophages, which are involved in tumorigenesis and in the suppression of antitumor immunity. Moreover, the CSF-1R/CSF-1 axis has been implicated in the pathogenesis of pigmented villonodular synovitis (PVNS), a benign tumor of the synovium. As advanced or metastatic malignant solid tumors and relapsed/refractory PVNS remain unresolved therapeutic problems, new approaches are needed to improve the outcome of patients with these conditions...
September 5, 2017: Current Oncology Reports
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