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https://www.readbyqxmd.com/read/28638690/an-unusual-case-of-diffuse-pigmented-villonodular-synovitis-of-the-shoulder-a-multidisciplinary-approach-with-arthroscopic-synovectomy-and-adjuvant-radiotherapy
#1
Tânia Quinás Serra, João Morais, Zico Gonçalves, Francisco Agostinho, Gilberto Melo, Mónica Henriques
Pigmented villonodular synovitis (PVNS) is a rare proliferative disorder of the synovial membrane. This condition is usually monoarticular, can be locally destructive, and involves muscles, tendons, bursae, bones, and skin. The most commonly affected joints are the knee and hip, followed by the ankle and shoulder. Patients often present with pain, swelling, and joint effusion; however, the duration of symptoms varies. Total synovectomy is the preferred treatment for PVNS. Subtotal synovectomy is a factor of recurrence, and in diffuse PVNS, total excision is very difficult to achieve...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28552192/long-term-outcome-of-knee-arthroplasty-in-the-setting-of-pigmented-villonodular-synovitis
#2
Matthew T Houdek, Maurizio Scorianz, Cody C Wyles, Robert T Trousdale, Franklin H Sim, Michael J Taunton
BACKGROUND: Pigmented villonodular synovitis (PVNS) is a rare, benign proliferation of the synovium, commonly affecting the knee. Arthroplasty can successfully manage arthrosis in this population; however, outcome data is limited. The purpose of this study was to investigate the oncologic and functional outcome of patients undergoing total knee arthroplasty (TKA) in the setting of PVNS. METHODS: 48 patients were identified at our institution with histologically confirmed PVNS that subsequently received TKA...
May 25, 2017: Knee
https://www.readbyqxmd.com/read/28461957/pigmented-villonodular-synovitis-of-the-hip
#3
Sylvain Steinmetz, Anne-Laure Rougemont, Robin Peter
Pigmented villonodular synovitis (PVNS) is a rare disease that can affect any joint, bursa or tendon sheath.The hip is less frequently affected than the knee, and hence is less discussed in scientific journals.PVNS of the hip mainly occurs in young adults, requiring early diagnosis and adequate treatment to obtain good results.There is no consensus on the management of PVNS of the hip in current literature.We will discuss the options for surgical intervention in hip PVNS using a literature review of clinical, biological, etiological, histological and radiographic aspects of the disease...
June 2016: EFORT open reviews
https://www.readbyqxmd.com/read/28442184/pigmented-villonodular-synovitis-of-the-knee-a-retrospective-analysis-of-214-cases-at-a-uk-tertiary-referral-centre
#4
K H Patel, P D Gikas, R C Pollock, R W Carrington, S R Cannon, J A Skinner, T W Briggs, W J S Aston
AIMS: Pigmented villonodular synovitis (PVNS) is a rare, locally aggressive and potentially recurrent synovial disease. We present the largest single-centre experience of knee PVNS. Our aim was to evaluate our tertiary hospital's experience in the management of knee PVNS. PATIENTS AND METHODS: Retrospective data collection of consecutive cases of knee PVNS from 2002 to 2015. RESULTS: In total, 214 cases of knee PVNS were identified which represented 53...
April 22, 2017: Knee
https://www.readbyqxmd.com/read/28440187/genetic-modifications-of-icosahedral-plant-virus-based-nanoparticles-for-vaccine-and-immunotherapy-applications
#5
Kannan Badri Narayanan, Sung Soo Han
Vaccine development is one of the greatest achievements of modern medicine. Vaccines made of live-attenuated pathogens can revert to virulent live strains, which causes safety concerns. On the other hand, the use of purified antigenic components as subunit vaccines is safer, but less effective, as these components induce lower levels of protective immunity. Multiple copy presentation of an antigenic determinant in a well-ordered and well-defined orientation on a nanosized particle can mimic the natural host-pathogen surface interaction to provide antigen stability and immunogenicity similar to that of conventional vaccines with improved safety...
April 24, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28436371/pigmented-villonodular-synovitis-various-manifestations-inconsistent-terminology-and-treatment-cases-study
#6
Paweł Kokoszka, Waldemar Woźniak, Łukasz Łapaj, Jacek Kruczyński
Pigmented villonodular synovitis (PVNS) as well as tenosynovial giant cell tumor (TGCT) are both diagnosed and described in two forms, namely a localized and diffuse type. They form a diverse group of proliferative lesions in articular synovium and tendon sheaths. The inconsistent terminology impedes communication between patients, orthopedic surgeons, radiologists and pathologists, leading to misunderstandings and delaying treatment. In this paper, we present three cases of PVNS/TGCT (involving the fourth toe extensor tendon sheath, hip joint after resurfacing and flexor hallucis longus tendon sheath) together with suggestions regarding the unification of the terminology as well as diagnosis and treatment...
January 26, 2017: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28428036/giant-cell-tumor-of-tendon-sheath-open-surgery-or-arthroscopic-synovectomy-a-systematic-review-of-the-literature
#7
REVIEW
T Noailles, K Brulefert, S Briand, P-M Longis, K Andrieu, A Chalopin, F Gouin
PURPOSE: Giant cell tumor of tendon sheath (GCTTS), formerly known as pigmented villonodular synovitis (PVNS), is a benign, locally aggressive, proliferative disorder of the synovium involving a joint, bursa, or tendon sheath. Treatment of GCTTS involves early surgical resection to limit articular destruction and the risk of recurrence. Synovectomy remains the treatment of choice for GCTTS, but without clear consensus to make an open or arthroscopic synovectomy and no certainty on the responsibility of surgery in the evolution towards the degenerative osteoarthritis...
April 17, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28389877/results-and-recurrence-of-pigmented-villonodular-synovitis-of-the-ankle-does-diffuse-pvns-with-extra-articular-extension-tend-to-recur-more-often
#8
QinWei Guo, WeiLi Shi, Chen Jiao, Xing Xie, Dong Jiang, YueLin Hu
PURPOSE: The aim of this study was to provide the outcomes and to analyze the recurrence of Pigmented Villonodular Synovitis (PVNS) of the ankle joint treated by surgical synovectomy. METHODS: Thirty-one PVNS cases of the ankle, including 5 localized PVNS cases and 26 diffuse PVNS cases, were treated in our institute between 2004 and 2015. The median age was 35 (range 18-63) years. The 5 localized PVNS cases were treated with partial synovectomy (group I); 10 diffuse PVNS cases limited to intra-articular synovium received arthroscopic comprehensive synovectomy (group II); and 16 cases with diffuse PVNS spreading to extra-articular tendon sheaths underwent combined arthroscopic and open synovectomy (group III)...
April 7, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28326214/open-and-arthroscopic-with-mini-open-surgical-hip-approaches-for-treatment-of-pigmented-villonodular-synovitis-and-concomitant-hip-pathology
#9
Bridget Ellsworth, Atul F Kamath
Background. Pigmented villonodular synovitis (PVNS) is a rare benign tumor affecting large joints and prompts excision to prevent local destruction of the joint. The purpose of this case report is to describe two differing surgical approaches for management of PVNS of the hip in patients requiring concomitant treatment for additional hip pathology. Methods. This report discusses the presentation, clinical and radiographic findings, and operative management of two contrasting cases of PVNS of the hip. Case 1 describes a 31-year-old female with localized PVNS in addition to a labral tear treated with arthroscopic labral repair followed by tumor excision via a mini-open incision...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28288478/benign-temporomandibular-joint-lesions-presenting-as-masses-in-the-external-auditory-canal
#10
Ryan A Williams, Robert K Jackler, C Eduardo Corrales
OBJECTIVE: Describe benign lesions arising from the temporomandibular joint (TMJ) that presented as masses in the external auditory canal (EAC). STUDY DESIGN: Retrospective case series of two academic medical centers. PATIENTS: Six patients with lesions emanating from the TMJ that presented as EAC masses. Lesions included pigmented villonodular synovitis (PVNS), nodular fasciitis, foramen of Huschke herniation with salivary fistula, fibroepithelial polyp, superficial angiomyxoma, and giant cell tumor (GCT)...
April 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28194649/numerical-modeling-of-percutaneous-auricular-vagus-nerve-stimulation-a-realistic-3d-model-to-evaluate-sensitivity-of-neural-activation-to-electrode-position
#11
Amine M Samoudi, Stefan Kampusch, Emmeric Tanghe, Jozsef C Széles, Luc Martens, Eugenijus Kaniusas, Wout Joseph
OBJECTIVE: Percutaneous stimulation of the auricular branch of the vagus nerve (pVNS) by miniaturized needle electrodes in the auricle gained importance as a treatment for acute and chronic pain. The objective is to establish a realistic numerical model of pVNS and investigate the effects of stimulation waveform, electrodes' depth, and electrodes' position on nerve excitation threshold and the percentage of stimulated nerves. METHODS: Simulations were performed with Sim4Life...
February 13, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28005642/tumorlike-pigmented-villonodular-synovitis-with-atypical-location-appearance-on-3-phase-99mtc-mdp-bone-scan
#12
Qian Hua, Jianming Ni
Pigmented villonodular synovitis (PVNS) is a proliferative disorder of unknown etiology that originates from the synovial membranes of joints. Some PVNS lesions have been misdiagnosed as malignancy due to their tumorlike imaging findings. There are few reports of PVNS on nuclear 3-phase bone imaging. However, 3-phase Tc-MDP bone scan can offer additional information about the dynamic flow features of the lesion, which may do help in differential benign and malignant. The present report describes 3-phase bone imaging in a surgically proven case of PVNS with tumorlike appearance and atypical location...
March 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27843734/pigmented-villonodular-synovitis-of-the-knee-joint-a-case-report
#13
Chirag Kapoor, Maulik Jhaveri, Rishit Soni, Malkesh Shah, Parth Rathi, Paresh Golwala
Pigmented villonodular synovitis (PVNS) is a rare, benign, but potentially locally aggressive and recurrent condition characterized by synovial proliferation and hemosiderin deposition inside the joints, tendon sheaths, and bursae. It usually affects the large joints such as hip, knee, and ankle. We report a case of PVNS of the knee joint in a young female which was treated by subtotal synovectomy alone without the use of adjuvants. At the 14-month follow-up, the patient was pain free and had no signs of disease recurrence...
October 4, 2016: Curēus
https://www.readbyqxmd.com/read/27720630/an-unusual-case-of-pigmented-villo-nodular-synovitis-of-the-second-toe-a-case-report-and-review-of-literature
#14
REVIEW
Pankaj Sharma, Vivek Tiwari, Shah Alam Khan, Shishir Rastogi
Pigmented villo-nodular synovitis (PVNS) is a common disease entity particularly in the knee joint but its incidence in the foot is quite rare. A case of PVNS of the second toe that presented at the outpatient department with an insidious onset and slowly progressive painful swelling of the toe associated with stiffness is presented. The mass was subsequently excised and the diagnosis confirmed by histo-pathology samples. The patient's symptoms improved significantly after the operation. This case is one of the very few reported cases of PVNS involvement of flexor tendon sheath of the foot...
August 2016: Foot
https://www.readbyqxmd.com/read/27609398/-pigmented-villonodular-synovitis-of-the-temporomandibular-joint%C3%AF-report-of-one-case-and-review-of-literatures
#15
REVIEW
Qian-Qian Gao, Yuan-Yong Feng, Ling-Xue Bu, Kai Song, Xin Dai, Wei Shang
Pigmented villonodular synovitis (PVNS) is a benign, proliferative disorder of synovium. It often affects the knee, and rarely occurs in the temporomandibular joint (TMJ). This paper reported a 45-year-old male patient with PVNS of the TMJ, who was referred with a chief complaint of slowly growing and painless preauricular mass that was noticed about 1 year. Radical excision and follow-up were conducted, no recurrence and metastasis were noted.
June 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/27600839/distinct-spatiotemporal-response-properties-of-excitatory-versus-inhibitory-neurons-in-the-mouse-auditory-cortex
#16
Ido Maor, Amos Shalev, Adi Mizrahi
In the auditory system, early neural stations such as brain stem are characterized by strict tonotopy, which is used to deconstruct sounds to their basic frequencies. But higher along the auditory hierarchy, as early as primary auditory cortex (A1), tonotopy starts breaking down at local circuits. Here, we studied the response properties of both excitatory and inhibitory neurons in the auditory cortex of anesthetized mice. We used in vivo two photon-targeted cell-attached recordings from identified parvalbumin-positive neurons (PVNs) and their excitatory pyramidal neighbors (PyrNs)...
October 17, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27537585/multifocal-pigmented-villonodular-synovitis-in-a-child-a-case-report
#17
Liang Zhao, Kaiyu Zhou, Yimin Hua, Yifei Li, Dezhi Mu
INTRODUCTION: Pigmented villonodular synovitis (PVNS) is a rare, benign proliferative disorder of the synovial membrane that typically presents in adults and affects a single joint. Multifocal PVNS is very rare, particularly in childhood. We reported a rare case of multifocal PVNS affecting over 20 joints in a child. CLINICAL PROCEDURE: A 7-year-old female patient had a 6-month history of multifocal joints swelling with mild pain. She was diagnosed as polyarticular juvenile idiopathic arthritis at a local hospital...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27499236/organ-specific-radiation-induced-cancer-risk-estimates-due-to-radiotherapy-for-benign-pigmented-villonodular-synovitis
#18
Michalis Mazonakis, Antonis Tzedakis, Efrossyni Lyraraki, John Damilakis
Pigmented villonodular synovitis (PVNS) is a benign disease affecting synovial membranes of young and middle-aged adults. The aggressive treatment of this disorder often involves external-beam irradiation. This study was motivated by the lack of data relating to the radiation exposure of healthy tissues and radiotherapy-induced cancer risk. Monte Carlo methodology was employed to simulate a patient's irradiation for PVNS in the knee and hip joints with a 6 MV photon beam. The average radiation dose received by twenty-two out-of-field critical organs of the human body was calculated...
September 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27462929/a-systematic-literature-review-of-synovial-chondromatosis-and-pigmented-villonodular-synovitis-of-the-hip
#19
REVIEW
Ashley Startzman, Devin Collins, Dominic Carreira
OBJECTIVES: Benign synovial diseases of the hip including Synovial Chondromatosis (SC) and Pigmented Villonodular Synovitis (PVNS) are devastating diseases. Initially, patients present with hip pain unrelieved by conservative measures. The diagnosis of PVNS and SC are often delayed, leading to progression of joint damage. The purpose of this review is to present the latest on the diagnosis, management, and prognosis of SC and PVNS of the hip. METHODS: An extensive systematic search of MEDLINE and PUBMED Databases was performed...
November 2016: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/27307879/hoffa-s-fat-pad-inflammation-in-an-hiv-positive-patient
#20
Jonelle Petscavage, Felix S Chew
Hoffa's syndrome involves inflammation of the infrapatellar fat pad secondary to direct trauma or microtrauma. Alternative sources of inflammation of Hoffa's fat pad include synovial processes such as pigmented villonodular synovitis (PVNS) and osteochondromatosis. Recently, a few cases of inflammation of Hoffa's fat pad secondary to human immunodeficiency virus (HIV) have been described. Our case presents an HIV patient with Hoffa's fat-pad inflammation as well as prefemoral fat-pad edema, posterior soft-tissue inflammation, and bone infarction...
2010: Radiology case reports
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