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Elevated troponin in exercise induced

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https://www.readbyqxmd.com/read/27609306/individual-responses-in-biomarkers-of-health-after-marathon-and-half-marathon-running-is-age-a-factor-in-troponin-changes
#1
Markus Niemelä, Päivikki Kangastupa, Onni Niemelä, Risto Bloigu, Tatu Juvonen
Although strenuous physical activity is known to cause notable perturbations in blood chemistries, only few studies exist observing exercise-induced simultaneous changes in biomarkers of health status. We compared markers of muscle, cardiovascular, renal, hepatic and inflammatory status at baseline and at 3-h and at 48-h postrace in recreational runners who successfully completed either a marathon (mean age 27 ± 13 years, finishing time 199 ± 8 min, n = 4) or half-marathon (mean age 38 ± 13 years, finishing time 131 ± 6 min, n = 6) race...
November 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27585757/early-invasive-versus-non-invasive-treatment-in-patients-with-non-st-elevation-acute-coronary-syndrome-frisc-ii-15-year-follow-up-of-a-prospective-randomised-multicentre-study
#2
RANDOMIZED CONTROLLED TRIAL
Lars Wallentin, Lars Lindhagen, Elisabet Ärnström, Steen Husted, Magnus Janzon, Søren Paaske Johnsen, Frederic Kontny, Tibor Kempf, Lars-Åke Levin, Bertil Lindahl, Mats Stridsberg, Elisabeth Ståhle, Per Venge, Kai C Wollert, Eva Swahn, Bo Lagerqvist
BACKGROUND: The FRISC-II trial was the first randomised trial to show a reduction in death or myocardial infarction with an early invasive versus a non-invasive treatment strategy in patients with non-ST-elevation acute coronary syndrome. Here we provide a remaining lifetime perspective on the effects on all cardiovascular events during 15 years' follow-up. METHODS: The FRISC-II prospective, randomised, multicentre trial was done at 58 Scandinavian centres in Sweden, Denmark, and Norway...
October 15, 2016: Lancet
https://www.readbyqxmd.com/read/27572505/the-impact-of-intermittent-exercise-in-a-hypoxic-environment-on-redox-status-and-cardiac-troponin-release-in-the-serum-of-well-trained-marathon-runners
#3
Feifei Li, Jinlei Nie, Yifan Lu, Tom Kwok Keung Tong, Longyan Yi, Huiping Yan, Frank Hoo Kin Fu, Shengxia Ma
PURPOSE: To investigate the effects of hypoxic training on redox status and cardiac troponin (cTn) release after intermittent exercise. METHOD: Nine well-trained male marathon runners (age, 21.7 ± 2.3 year; body mass, 64.7 ± 4.8 kg; height, 177.9 ± 3.8 cm; and VO2max, 64.3 ± 6.7 ml kg(-1) min(-1)) completed intermittent exercise under normoxic [trial N; fraction of inspiration oxygen (FIO2), 21.0 %] and hypoxic (trial H; FIO2, 14.4 %) conditions in random order...
October 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27430157/the-impact-of-remote-ischemic-preconditioning-on-cardiac-biomarker-and-functional-response-to-endurance-exercise
#4
S Cocking, T Landman, M Benson, R Lord, H Jones, D Gaze, D H J Thijssen, K George
Remote ischemic preconditioning (RIPC; repeated short reversible periods of ischemia) protects the heart against subsequent ischemic injury. We explored whether RIPC can attenuate post-exercise changes in cardiac troponin T (cTnT) and cardiac function in healthy individuals. In a randomized, crossover design, 14 participants completed 1-h cycling time trials (TT) on two separate visits; preceded by RIPC (arms/legs, 4 × 5-min 220 mmHg), or SHAM-RIPC (20 mmHg). Venous blood was sampled before and 0-, 1-, and 3-h post-exercise to assess high sensitivity (hs-)cTnT and brain natriuretic peptide (NT-proBNP)...
July 19, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27420587/troponin-and-exercise
#5
REVIEW
T Gresslien, S Agewall
Cardiac troponins are the preferred biomarkers in diagnostic of myocardial infarction, but these markers also can rise in response to exercise. Multiple studies have assessed troponins post-exercise, but the results have varied and there have been disagreements about the mechanism of troponin release. The aim of this paper was to review the literature, and to consider factors and mechanisms regarding exercise-induced increase of troponin. 145 studies were found after a search in pubmed and inclusion of additional articles found in the reference list of the first articles...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27282835/cardiac-troponin-t-and-i-release-after-a-30-km-run
#6
Lieke J J Klinkenberg, Peter Luyten, Noreen van der Linden, Kim Urgel, Daniëlle P C Snijders, Christian Knackstedt, Robert Dennert, Bastiaan L J H Kietselaer, Alma M A Mingels, Eline P M Cardinaels, Frederique E C M Peeters, Jeroen D E van Suijlen, Joop Ten Kate, Elke Marsch, Thomas L Theelen, Judith C Sluimer, Kristiaan Wouters, Otto Bekers, Sebastiaan C A M Bekkers, Luc J C van Loon, Marja P van Dieijen-Visser, Steven J R Meex
Prolonged endurance-type exercise is associated with elevated cardiac troponin (cTn) levels in asymptomatic recreational athletes. It is unclear whether exercise-induced cTn release mirrors a physiological or pathological underlying process. The aim of this study was to provide a direct comparison of the release kinetics of high-sensitivity cTnI (hs-cTnI) and T (hs-cTnT) after endurance-type exercise. In addition, the effect of remote ischemic preconditioning (RIPC), a cardioprotective strategy that limits ischemia-reperfusion injury, was investigated in a randomized controlled crossover manner...
July 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/26864794/strenuous-exercise-induces-a-hyperreactive-rebalanced-haemostatic-state-that-is-more-pronounced-in-men
#7
Dana Huskens, Mark Roest, Jasper A Remijn, Joke Konings, Romy M W Kremers, Saartje Bloemen, Evelien Schurgers, Anna Selmeczi, Hilde Kelchtermans, Rinaldo van Meel, Steven J Meex, Marie-Claire Kleinegris, Philip G de Groot, Rolf T Urbanus, Marisa Ninivaggi, Bas de Laat
Physical exercise is recommended for a healthy lifestyle. Strenuous exercise, however, may trigger the haemostatic system, increasing the risk of vascular thrombotic events and the incidence of primary cardiac arrest. Our goal was to study the effects of strenuous exercise on risk factors of cardiovascular disease. Blood was collected from 92 healthy volunteers who participated in the amateur version of the pro-tour Amstel Gold cycling race, before and directly after the race. Thrombin generation showed a shortening of the lag time and time to peak and an increase of the velocity index...
June 2, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/26241808/-coronary-artery-anomaly-common-cause-of-sudden-cardiac-death-in-young-people-unusual-diagnosis-that-requires-a-targeted-investigation-in-order-not-to-be-missed
#8
Hanna Fischer, Anders Hedman, Tomas Öhman
17-year old male was admitted after syncope during exercise, exhibiting transient ST-elevation, raised troponin T levels and regionally hypokinetic myocardium. Further investigation revealed a left main coronary artery arising from the right sinus valsalva, a narrow vessel with an intramural course resulting in compression during systole. The patient had presented previously with chest pain and syncope during physical exercise. After CT-angiography, ECG, Tilt-test and ECHO he was diagnosed with vasomotor induced syncope...
August 4, 2015: Läkartidningen
https://www.readbyqxmd.com/read/26089013/usefulness-of-high-sensitive-troponin-elevation-after-effort-stress-to-unveil-vulnerable-myocardium-in-patients-with-heart-failure
#9
Luigi Emilio Pastormerlo, Assunta Agazio, Eleonora Benelli, Alessandra Gabutti, Roberta Poletti, Concetta Prontera, Aldo Clerico, Michele Emdin, Claudio Passino
Elevation of resting high-sensitivity troponin (hs-Tn) holds prognostic value in heart failure (HF), but its pathophysiological meaning is unclear. We aimed to investigate hs-Tn elevation after maximal exercise in patients with systolic HF and its neurohormonal and hemodynamic correlates: 30 patients diagnosed with systolic HF (left ventricular ejection fraction 32 ± 8%, mean ± SD), on guideline-directed medical therapy and not recognized inducible ischemia, underwent maximal cardiopulmonary stress test, with assay of plasma N-terminal proB-type natriuretic peptide (NT-proBNP), norepinephrine (NE), and hs-TnT (hs-TnT) at baseline, peak, and 1 and 4 hours after exercise...
August 15, 2015: American Journal of Cardiology
https://www.readbyqxmd.com/read/25943765/effects-of-acute-intermittent-exercise-in-hypoxic-environments-on-the-release-of-cardiac-troponin
#10
F Li, Y Hu, J Nie, F H Fu
The purpose of this study was to examine the effects of acute, intermittent exercise performed in hypoxic environments on the release of cardiac troponin (cTn). Ten well-trained, male marathon runners (22.1 ± 2.6 years, 64.0 ± 4.9 kg and 177.3 ± 3.9 cm) completed three intermittent exercise protocols under normoxic (trial N) and hypoxic (trial AH and RH) conditions. In trial N, the fraction of inspiration oxygen (FIO2 ) was 21.0% and exercise intensity was 90% and 50% normoxic velocity of VO2max (vVO2max)...
April 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/25681432/impact-of-an-endurance-training-program-on-exercise-induced-cardiac-biomarker-release
#11
RANDOMIZED CONTROLLED TRIAL
Alejandro Legaz-Arrese, Isaac López-Laval, Keith George, Juan José Puente-Lanzarote, Carmen Mayolas-Pi, Enrique Serrano-Ostáriz, Pablo Revilla-Martí, Diego Moliner-Urdiales, Joaquín Reverter-Masià
We evaluated the influence of a 14-wk endurance running program on the exercise-induced release of high-sensitivity cardiac troponin T (hs-cTnT) and NH2-terminal pro-brain natriuretic peptide (NT-proBNP). Fifty-eight untrained participants were randomized to supervised endurance exercise (14 wk, 3-4 days/wk, 120-240 min/wk, 65-85% of maximum heart rate) or a control group. At baseline and after the training program, hs-cTnT and NT-proBNP were assessed before and 5 min, 1 h, 3 h, 6 h, 12 h, and 24 h after a 60-min maximal running test...
April 15, 2015: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/25673189/association-between-cardiac-changes-and-stress-and-the-effect-of-peroxisome-proliferator-activated-receptor-%C3%AE-on-stress-induced-myocardial-injury-in-mice
#12
Jin-liao Gao, Qiao Xue, Shi-wen Wang, Li-fei Gao, Yun-feng Lan, Zhou Fang, Yi-cheng Fu, Yan Liu, Yang Li, Li Fan
This study was aimed to investigate the effect of stress induced by high-intensity exercises on the cardiovascular system. In the epidemiological investigation, 200 subjects (test group) engaged in special high-intensity exercises, and 97 who lived and worked in the same environment and conditions as those in the test group, but did not participate in the exercises served as controls. In the second part of the study, 50 mice were randomly divided into control group, exhaustive swimming group, white noise group, exhaustive swimming plus white noise group, and pioglitazone intervention group...
February 2015: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/25508433/-a-troponin-detection-combined-study-of-rabbit-experiment-for-evaluating-cardiac-fatigue
#13
Xiaobo Yan, Linmei Luo, Shouzhong Xiao, Leichu Liu, Suyuan Deng, Cong Zhang, Guoxiang Xia
The objective of this study is to combine troponin and indicators of cardiac acoustics for synthetically evaluating cardiac fatigue of rabbits, analyzing exercise-induced cardiac fatigue (EICF) and exercise-induced cardiac damage (EICD). New Zealand white rabbits were used to conduct a multi-step swimming experiments with load, reaching an exhaustive state for evaluating if the amplitude ratio of the first to second heart sound (S1/S2) and heart rate (HR) during the exhaustive exercise would decrease or not and if they would be recovered 24-48 h after exhaustive exercise...
August 2014: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/25464802/-a-troponin-detection-combined-study-of-rabbit-experiment-for-evaluating-cardiac-fatigue
#14
Xiaobo Yan, Linmei Luo, Shouzhong Xiao, Leichu Liu, Suyuan Deng, Cong Zhang, Guoxiang Xia
The objective of this study is to combine troponin and indicators of cardiac acoustics for synthetically evaluating cardiac fatigue of rabbits, analyzing exercise-induced cardiac fatigue (EICF) and exercise-induced cardiac damage (EICD). New Zealand white rabbits were used to conduct a multi-step swimming experiments with load, reaching an exhaustive state for evaluating if the amplitude ratio of the first to second heart sound (S1/S2) and heart rate (HR) during the exhaustive exercise would decrease or not and if they would be recovered 24-48 h after exhaustive exercise...
August 2014: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/25075937/coronary-microvascular-spasm-triggers-transient-ischemic-left-ventricular-diastolic-abnormalities-in-patients-with-chest-pain-and-angiographically-normal-coronary-arteries
#15
Antonio Luis Arrebola-Moreno, Juan Pedro Arrebola, Antonio Moral-Ruiz, Jose Antonio Ramirez-Hernandez, Rafael Melgares-Moreno, Juan Carlos Kaski
AIMS: Impaired coronary microvascular dilatory function can lead to exercise induced myocardial ischemia and angina pectoris even in patients without significant (>50%) obstructive coronary atherosclerosis (APWOCA). Diffuse distal vessel epicardial spasm and microvascular spasm have been also proposed as a plausible explanation for angina at rest in these patients. However, objective systematic evidence for the latter i.e. echocardiographic wall motion abnormalities during angina, is lacking at present...
September 2014: Atherosclerosis
https://www.readbyqxmd.com/read/25015693/impact-of-statin-use-on-exercise-induced-cardiac-troponin-elevations
#16
Thijs M H Eijsvogels, James L Januzzi, Beth A Taylor, Stephanie K Isaacs, Pierre D'Hemecourt, Amanda Zaleski, Sophia Dyer, Chris Troyanos, Rory B Weiner, Paul D Thompson, Aaron L Baggish
Marathon running commonly causes a transient elevation of creatine kinase and cardiac troponin I (cTnI). The use of statins before marathon running exacerbates the release of creatine kinase from skeletal muscle, but the effect of statin use on exercise-induced cTnI release is unknown. We therefore measured cTnI concentrations in statin-using (n = 30) and nonstatin-using (n = 41) runners who participated in the 2011 Boston Marathon. All runners provided venous blood samples the day before, within an hour of finishing, and 24 hours after the marathon...
August 15, 2014: American Journal of Cardiology
https://www.readbyqxmd.com/read/24504429/heart-rate-and-its-variability-in-response-to-running-associations-with-troponin
#17
Philip Aagaard, Anders Sahlén, Lennart Bergfeldt, Frieder Braunschweig
PURPOSE: The objective of this study is to investigate the time course of autonomic tone changes after a first-time endurance running race participation and associations with postexertional high-sensitivity troponin (hsTnT) levels in middle-aged males. METHODS: Male (n = 42) first-time long-distance running race (Lidingöloppet 30 km) participants ≥45 yr (50.5 ± 5) were examined. HR and HR variability (HRV) in the time domain (SDANN) was measured continuously from 2 d before to 4 d after the race using a wireless cardiovascular monitor that also recorded arrhythmia episodes...
August 2014: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/24484196/influence-of-training-and-a-maximal-exercise-test-in-analytical-variability-of-muscular-hepatic-and-cardiovascular-biochemical-variables
#18
Marco Romagnoli, Rafael Alis, Rosalia Aloe, Gian Luca Salvagno, Javier Basterra, Helios Pareja-Galeano, Fabian Sanchis-Gomar, Giuseppe Lippi
Short, middle, and long-term exercise, as well as the relative intensity of the physical effort, may influence a broad array of laboratory results, and it is thereby of pivotal importance to appropriately differentiate the 'physiologic' from the 'pathological' effects of exercise. Therefore, the values of some biomarkers in physically active subjects may be cautiously interpreted since the results may fall outside the conventional reference ranges. It has been demonstrated that middle and long-term endurance and/or strenuous exercise triggers transient elevations of muscular and cardiac biomarkers...
April 2014: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/24436293/rapid-upregulation-and-clearance-of-distinct-circulating-micrornas-after-prolonged-aerobic-exercise
#19
Aaron L Baggish, Joseph Park, Pil-Ki Min, Stephanie Isaacs, Beth A Parker, Paul D Thompson, Chris Troyanos, Pierre D'Hemecourt, Sophia Dyer, Marissa Thiel, Andrew Hale, Stephen Y Chan
Short nonprotein coding RNA molecules, known as microRNAs (miRNAs), are intracellular mediators of adaptive processes, including muscle hypertrophy, contractile force generation, and inflammation. During basal conditions and tissue injury, miRNAs are released into the bloodstream as "circulating" miRNAs (c-miRNAs). To date, the impact of extended-duration, submaximal aerobic exercise on plasma concentrations of c-miRNAs remains incompletely characterized. We hypothesized that specific c-miRNAs are differentially upregulated following prolonged aerobic exercise...
March 1, 2014: Journal of Applied Physiology
https://www.readbyqxmd.com/read/24260184/effect-of-antioxidant-supplementation-on-exercise-induced-cardiac-troponin-release-in-cyclists-a-randomized-trial
#20
RANDOMIZED CONTROLLED TRIAL
Lieke J J Klinkenberg, Peter T Res, Guido R Haenen, Aalt Bast, Luc J C van Loon, Marja P van Dieijen-Visser, Steven J R Meex
BACKGROUND: Cardiac troponin is the biochemical gold standard to diagnose acute myocardial infarction. Interestingly however, elevated cardiac troponin concentrations are also frequently observed during and after endurance-type exercise. Oxidative stress associated with prolonged exercise has been proposed to contribute to cardiac troponin release. Therefore, the aim of this study was to assess the effect of 4 week astaxanthin supplementation (a potent cartenoid antioxidant) on antioxidant capacity and exercise-induced cardiac troponin release in cyclists...
2013: PloS One
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