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https://www.readbyqxmd.com/read/28227598/real-time-physiological-and-facial-monitoring-for-safe-driving
#1
Yu-Lung Chang, Yen-Cheng Feng, Oscal T-C Chen, Yu-Lung Chang, Yen-Cheng Feng, Oscal T-C Chen, Yen-Cheng Feng, Oscal T-C Chen, Yu-Lung Chang
This work is to develop an intelligent driver-assistance system which can perceive the physiological state of a driver to avoid fatigue driving. The proposed system includes a camera, a wireless ElectroCardioGram (ECG) sensor patch, and a computation platform. The camera in front of a driver is to catch a face image which is processed to obtain features of a mouth for identifying a yawn. The sensor patch records ECG signals which are computed to yield six Heart Rate Variability (HRV) parameters. Seven healthy subjects of 6 males and 1 female had individually driven a car, which was embedded with our system, for 3 hours at a well-known route, mostly in a freeway road...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227498/effects-of-the-choice-of-reference-on-the-selectivity-of-a-multi-contact-nerve-cuff-electrode
#2
Ryan G L Koh, Jose Zariffa, Ryan G L Koh, Jose Zariffa, Jose Zariffa, Ryan G L Koh
Tripolar referencing is typically used in nerve cuff electrode recordings due to its ability to maximize the signal-to-noise ratio of contacts at the centre, but this may not be the optimal choice for a multi-contact nerve cuff consisting of contacts in off-centre rings. We conducted a simulation study to compare the effects of 3 different reference types on the recording selectivity of a multi-contact nerve cuff: the tripolar reference (TPR), common average reference (CAR), and multiple tripolar references based on consecutive groups of 3 rings (cTPR)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227311/two-microphones-spectral-coherence-based-speech-enhancement-for-hearing-aids-using-smartphone-as-an-assistive-device
#3
Chandan K A Reddy, Yiya Hao, Issa Panahi, Chandan K A Reddy, Yiya Hao, Issa Panahi, Issa Panahi, Chandan K A Reddy, Yiya Hao
In this paper, we present a new Speech Enhancement (SE) technique capable of running on a smartphone, as an assistive device for hearing aids (HAs). The developed method incorporates the coherence between the speech and noise signals to obtain a SE gain function which is used in conjunction with the gain function obtained by Spectral Subtraction using adaptive gain averaging. SE using coherence based gain function is found to suppress the background noise well, while inducing speech distortion. On the other hand, SE using Spectral Subtraction improves speech quality with tolerable speech distortion, but introduces background musical noise for certain noise types...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227093/applicability-of-ssvep-based-brain-computer-interfaces-for-robot-navigation-in-real-environments
#4
Christina Farmaki, Georgios Christodoulakis, Vangelis Sakkalis, Christina Farmaki, Georgios Christodoulakis, Vangelis Sakkalis, Vangelis Sakkalis, Christina Farmaki, Georgios Christodoulakis
Brain-computer interfaces have been extensively studied and used in order to aid patients suffering from neuromuscular diseases to communicate and control the surrounding environment. Steady-state visual evoked potentials (SSVEP) constitute a very popular BCI stimulation protocol, due to their efficiency and quick response time. In this study, we developed a SSVEP-based BCI along with a low-cost custom radio-controlled robot-car providing live video feedback from a wireless camera mounted on the robot, serving as our testbed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226626/detection-of-steering-direction-using-eeg-recordings-based-on-sample-entropy-and-time-frequency-analysis
#5
P Caldero-Bardaji, X Longfei, S Jaschke, J Reermann, K G Mideska, G Schmidt, G Deuschl, M Muthuraman, P Caldero-Bardaji, X Longfei, S Jaschke, J Reermann, K G Mideska, G Schmidt, G Deuschl, M Muthuraman, J Reermann, X Longfei, P Caldero-Bardaji, G Deuschl, K G Mideska, S Jaschke, G Schmidt, M Muthuraman
Monitoring driver's intentions beforehand is an ambitious aim, which will bring a huge impact on the society by preventing traffic accidents. Hence, in this preliminary study we recorded high resolution electroencephalography (EEG) from 5 subjects while driving a car under real conditions along with an accelerometer which detects the onset of steering. Two sensor-level analyses, sample entropy and time-frequency analysis, have been implemented to observe the dynamics before the onset of steering. Thus, in order to classify the steering direction we applied a machine learning algorithm consisting of: dimensionality reduction and classification using principal-component-analysis (PCA) and support-vector-machine (SVM), respectively...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226444/smartphone-based-noise-adaptive-speech-enhancement-for-hearing-aid-applications
#6
Issa Panahi, Nasser Kehtarnavaz, Linda Thibodeau, Issa Panahi, Nasser Kehtarnavaz, Linda Thibodeau, Issa Panahi, Nasser Kehtarnavaz, Linda Thibodeau
It is well established that the presence of environmental noises has a negative impact on the performance of hearing aid devices. This paper addresses a noise adaptive speech enhancement solution for the purpose of improving the performance of hearing aid devices in noisy environments. Depending on three noise types of babble, machinery, and driving car, the parameters of a recently developed speech enhancement algorithm are appropriately adjusted to gain improved speech understanding performance in noisy environments...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226253/modeling-single-vehicle-run-off-road-crash-severity-in-rural-areas-accounting-for-unobserved-heterogeneity-and-age-difference
#7
Linfeng Gong, Wei David Fan
This study investigates factors that significantly contribute to the severity of driver injuries resulting from single-vehicle run-off-road (SV ROR) crashes. A mixed logit model approach is employed to explore the potential unobserved heterogeneous effects associated with each age group: young (ages 16-24), middle-aged (ages 25-65), and older drivers (ages over 65). Likelihood ratio tests indicated that the development of separate injury severity models for each age group is statistically superior to estimating a single model using all data...
February 19, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28226205/car-o-rotamers-in-3-3-disubstituted-binol-esters
#8
Takeo Sakai, Junpei Matsuoka, Masayuki Shintai, Yuji Mori
Rotamers around the CAr-O bond were disclosed in 3,3'-disubstituted BINOL esters by NMR spectroscopy. A bulky R(1) group increased the rotational barrier. The pivalate showed two rotamers at 2 °C, and broad signals were observed close to room temperature when R(2) = Ph. The highest rotational barrier was recorded for the (tetracyanocyclopentadienyl)carboxylate, and C-O rotamers were present at room temperature. DFT calculations indicated the presence of repulsion between R(1) and R(2) during rotation of the CAr-O bond...
February 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28225754/targeting-a-car-to-the-trac-locus-with-crispr-cas9-enhances-tumour-rejection
#9
Justin Eyquem, Jorge Mansilla-Soto, Theodoros Giavridis, Sjoukje J C van der Stegen, Mohamad Hamieh, Kristen M Cunanan, Ashlesha Odak, Mithat Gönen, Michel Sadelain
Chimeric antigen receptors (CARs) are synthetic receptors that redirect and reprogram T cells to mediate tumour rejection. The most successful CARs used to date are those targeting CD19 (ref. 2), which offer the prospect of complete remission in patients with chemorefractory or relapsed B-cell malignancies. CARs are typically transduced into the T cells of a patient using γ-retroviral vectors or other randomly integrating vectors, which may result in clonal expansion, oncogenic transformation, variegated transgene expression and transcriptional silencing...
February 22, 2017: Nature
https://www.readbyqxmd.com/read/28224758/physical-and-social-determinants-of-dietary-variety-among-older-adults-living-alone-in-japan
#10
Yoshiharu Fukuda, Midori Ishikawa, Tetsuji Yokoyama, Tatsumi Hayashi, Tomoki Nakaya, Yukari Takemi, Kaoru Kusama, Nobuo Yoshiike, Miho Nozue, Kaori Yoshiba, Nobuko Murayama
AIM: Food security and sufficient nutrient intake are critical to longevity and active aging. The present study aimed to elucidate physical and social factors related to dietary variety among single-living older adults in Japanese communities. METHODS: The cross-sectional survey with a self-administrated questionnaire was carried out for all older adults living alone aged 65 years and older in three cities of Japan during 2014. Dietary variety score (DVS) was determined by counting the number of 10 food groups consumed at least once in 2 days using a food frequency questionnaire...
February 22, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28223464/reversal-of-pap-failure-with-the-repap-protocol
#11
Barry Krakow, Victor A Ulibarri, Natalia D McIver, Carli Yonemoto, Alyssa Tidler, Jessica Obando, Michelle R Foley-Shea, Jonathan Ornelas, Spencer Dawson
BACKGROUND: Re-titrations, an atypical approach to reverse PAP failure, was investigated retrospectively. METHODS: Application of our re-titration of PAP (REPAP) protocol in subjects with previous PAP failure assessed original technology (masks, modes, and pressures) in 273 subjects, of which 70% reported co-occurring psychiatric conditions. The REPAP protocol emphasized changes in pressure modes and settings to address expiratory pressure intolerance and residual breathing events; mask changes were facilitated...
February 21, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28223189/the-unrealised-potential-of-bike-share-schemes-to-influence-population-physical-activity-levels-a-narrative-review
#12
Adrian Bauman, Melanie Crane, Bradley Alan Drayton, Sylvia Titze
The recent proliferation of bike share schemes (BSS, also known as public bicycle use programs) in many cities has focused attention on their potential for reducing motorised traffic congestion, improving air quality and reducing car use. Since 2005, hundreds of bike share schemes have been implemented in many cities, with bike share usage patterns monitored in many of them. This paper assesses the development of BSS and provides a rationale for their potential health benefits. The key research question, as yet unanswered, is whether BSS themselves can contribute to improving population health, particularly through increasing population cycling, which would increase population levels of health-enhancing physical activity...
February 18, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28223183/four-distinct-types-of-e-c-1-2-1-30-enzymes-can-catalyze-the-reduction-of-carboxylic-acids-to-aldehydes
#13
Holly Stolterfoht, Daniel Schwendenwein, Christoph W Sensen, Florian Rudroff, Margit Winkler
Increasing demand for chemicals from renewable resources calls for the development of new biotechnological methods for the reduction of oxidized bio-based compounds. Enzymatic carboxylate reduction is highly selective, both in terms of chemo- and product selectivity, but not many carboxylate reductase enzymes (CARs) have been identified on the sequence level to date. Thus far, their phylogeny is unexplored and very little is known about their structure-function-relationship. CARs minimally contain an adenylation domain, a phosphopantetheinylation domain and a reductase domain...
February 18, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28223167/intracavitary-t4-immunotherapy-of-malignant-mesothelioma-using-pan-erbb-re-targeted-car-t-cells
#14
Astero Klampatsa, Daniela Y Achkova, David M Davies, Ana C Parente-Pereira, Natalie Woodman, James Rosekilly, Georgina Osborne, Thivyan Thayaparan, Andrea Bille, Michael Sheaf, James F Spicer, Juliet King, John Maher
Malignant mesothelioma remains an incurable cancer. We demonstrated that mesotheliomas expressed EGFR (79.2%), ErbB4 (49.0%) and HER2 (6.3%), but lacked ErbB3. At least one ErbB family member was expressed in 88% of tumors. To exploit ErbB dysregulation in this disease, patient T-cells were engineered by retroviral transduction to express a panErbB-targeted chimeric antigen receptor (CAR), co-expressed with a chimeric cytokine receptor that allows interleukin (IL)-4 mediated CAR T-cell proliferation. This combination is referred to as T4 immunotherapy...
February 18, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28222796/new-development-in-car-t-cell-therapy
#15
REVIEW
Zhenguang Wang, Zhiqiang Wu, Yang Liu, Weidong Han
Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have yielded unprecedented efficacy in B cell malignancies, most remarkably in anti-CD19 CAR-T cells for B cell acute lymphoblastic leukemia (B-ALL) with up to a 90% complete remission rate. However, tumor antigen escape has emerged as a main challenge for the long-term disease control of this promising immunotherapy in B cell malignancies. In addition, this success has encountered significant hurdles in translation to solid tumors, and the safety of the on-target/off-tumor recognition of normal tissues is one of the main reasons...
February 21, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28220679/the-lac-m%C3%A3-gantic-derailment-corporate-regulation-and-neoliberal-sovereignty
#16
David Tyler Dunford
On July 6, 2013, Montreal, Maine, and Atlantic railcar 5017 hauling 72 tanker cars of Bakken crude oil derailed over the town of Lac-Mégantic, Quebec. The town erupted in a fiery inferno as 5,560,000 liters of highly flammable Bakken crude oil exploded over the town, killing 47 people and contaminating 558,000 tons of soil and local waterways. While Montreal, Maine, and Atlantic Rail Chairman Edward Burkhardt initially blamed the derailment on the lone engineer and local firefighters, this study shows how Transport Canada and the rail industry undermined regulatory and safety measures for several years before the derailment...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28220549/somatic-psychological-and-sexual-triggers-for-overactive-bladder-syndrome-in-women
#17
Ariel Zilberlicht, Nir Haya, Ido Feferkorn, Eyal Goldschmidt, Anis Kaldawy, Yoram Abramov
AIMS: Patients with overactive bladder (OAB) often describe somatic, psychological, and sexual triggers for their symptoms. The aim of this study was to characterize these triggers and assess their impact on patients' symptoms and quality of life (QoL). METHODS: Patients who visited our urogynecologic clinic between August 2015 and March 2016 and diagnosed with OAB syndrome were asked to fill a questionnaire comprising 34 statements regarding SOmatic, Psychological, and Sexual Triggers for OAB (SOPSETO)...
February 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28218641/the-role-of-personality-traits-through-habit-and-intention-on-determining-future-preferences-of-public-transport-use
#18
Mahdi Yazdanpanah, Mansour Hadji Hosseinlou
A complex set of factors may affect transportation mode choice. While earlier studies have often considered objective factors in determining preferences of public transport use as a sustainable transportation, subjective factors such as personality traits are underexplored. Therefore, this study aimed to investigate the influence of personality traits on the number of future public transport use. Additionally, "car habit" and "intention toward using public modes" were considered to be important. For this purpose, a case study from departure passengers at Imam Khomeini International Airport (IKIA, Tehran, Iran) was conducted between January and February 2015 at IKIA...
February 17, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28218593/video-feedback-intervention-to-enhance-the-safety-of-older-drivers-with-cognitive-impairment
#19
Brian R Ott, Jennifer D Davis, Kimberly Bixby
OBJECTIVE: To demonstrate that g-force technology can be used to help older adults with cognitive impairment improve their driving safety as part of an in-car video feedback intervention. METHOD: Unsafe driving events triggered g-forces leading to capture of video clips. The program included 3 mo of monitoring without intervention, 3 mo of intervention (weekly written progress reports, a DVD of unsafe driving events, and weekly telephone contacts), and 3 mo of postintervention monitoring...
March 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28218408/toxaphene-induced-mouse-liver-tumorigenesis-is-mediated-by-the-constitutive-androstane-receptor
#20
Zemin Wang, Xilin Li, Qiangen Wu, James C Lamb, James E Klaunig
Toxaphene was shown to increase liver tumor incidence in B6C3F1 mice following chronic dietary exposure. Preliminary evidence supported a role for the constitutive androstane receptor (CAR) in the mode of action of toxaphene-induced mouse liver tumors. However, these results could not rule out a role for the pregnane X receptor (PXR) in liver tumor formation. To define further the nuclear receptors involved in this study, we utilized CAR, PXR and PXR/CAR knockout mice (CAR(-/-) , PXR(-/-) and PXR(-/-) /CAR(-/-) ) along with the wild-type C57BL/6...
February 20, 2017: Journal of Applied Toxicology: JAT
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