keyword
MENU ▼
Read by QxMD icon Read
search

CAR

keyword
https://www.readbyqxmd.com/read/28441153/discharge-criteria-for-the-late-preterm-infant-a-review-of-the-literature
#1
Jenny M Quinn, Marteen Sparks, Sheila M Gephart
BACKGROUND: Standardized late preterm infant (LPI) discharge criteria ensure best practice and help guide the neonatal provider to determine the appropriate level of care following birth. However, the location can vary from the well newborn setting to the neonatal intensive care unit (NICU). PURPOSE: The purpose of this review is to examine differences in LPI discharge criteria between the well newborn setting and the NICU by answering the clinical questions, "What are the recommended discharge criteria for the LPI and do they differ if admitted to the well newborn setting versus the NICU?" SEARCH STRATEGY: Databases searched include CINAHL, TRIP, PubMed, and the Cochrane Library...
April 24, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28439067/perfluorooctanesulfonate-pfos-induced-sertoli-cell-injury-through-a-disruption-of-f-actin-and-microtubule-organization-is-mediated-by-akt1-2
#2
Ying Gao, Haiqi Chen, Xiang Xiao, Wing-Yee Lui, Will M Lee, Dolores D Mruk, C Yan Cheng
PFOS (perfluorooctanesulfonate, or perfluorooctane sulfonic acid) is an anthropogenic fluorosurfactant widely used in consumer products. While its use in Europe, Canada and the U.S. has been banned due to its human toxicity, it continues to be used in China and other developing countries as a global pollutant. Herein, using an in vitro model of Sertoli cell blood-testis barrier (BTB), PFOS was found to induce Sertoli cell injury by perturbing actin cytoskeleton through changes in the spatial expression of actin regulatory proteins...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28437941/effect-of-scattering-on-coherent-anti-stokes-raman-scattering-cars-signals
#3
Janaka C Ranasinghesagara, Giuseppe De Vito, Vincenzo Piazza, Eric O Potma, Vasan Venugopalan
We develop a computational framework to examine the factors responsible for scattering-induced distortions of coherent anti-Stokes Raman scattering (CARS) signals in turbid samples. We apply the Huygens-Fresnel wave-based electric field superposition (HF-WEFS) method combined with the radiating dipole approximation to compute the effects of scattering-induced distortions of focal excitation fields on the far-field CARS signal. We analyze the effect of spherical scatterers, placed in the vicinity of the focal volume, on the CARS signal emitted by different objects (2μm diameter solid sphere, 2μm diameter myelin cylinder and 2μm diameter myelin tube)...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437778/strengthening-governance-for-intertidal-ecosystems-requires-a-consistent-definition-of-boundaries-between-land-and-sea
#4
Stefanie M Rog, Carly N Cook
The protection of intertidal ecosystems is complex because they straddle both marine and terrestrial realms. This leads to inconsistent characterisation as marine and/or terrestrial systems, or neither. Vegetated intertidal ecosystems are especially complex to classify because they can have an unclear border with terrestrial vegetation, causing confusion around taxonomy (e.g., mangrove-like plants). This confusion and inconsistency in classification can impact these systems through poor governance and incomplete protection...
April 21, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28437652/review-of-take-home-pesticide-exposure-pathway-in-children-living-in-agricultural-areas
#5
REVIEW
Carly Hyland, Ouahiba Laribi
BACKGROUND: Children of farmworkers may be chronically exposed to pesticides via the take-home exposure pathway. OBJECTIVE: The goal of this review was to analyze scientific literature evaluating the role of the take-home pesticide exposure pathway in children of agricultural workers. METHODS: A systematic review was undertaken and inclusion criteria were applied to identify original articles of interest. Of the 30 articles included in this review, some belonged to the same studies, resulting in a total of 23 studies...
April 21, 2017: Environmental Research
https://www.readbyqxmd.com/read/28436934/biopolymers-codelivering-engineered-t-cells-and-sting-agonists-can-eliminate-heterogeneous-tumors
#6
Tyrel T Smith, Howell F Moffett, Sirkka B Stephan, Cary F Opel, Amy G Dumigan, Xiuyun Jiang, Venu G Pillarisetty, Smitha P S Pillai, K Dane Wittrup, Matthias T Stephan
Therapies using T cells that are programmed to express chimeric antigen receptors (CAR T cells) consistently produce positive results in patients with hematologic malignancies. However, CAR T cell treatments are less effective in solid tumors for several reasons. First, lymphocytes do not efficiently target CAR T cells; second, solid tumors create an immunosuppressive microenvironment that inactivates T cell responses; and third, solid cancers are typified by phenotypic diversity and thus include cells that do not express proteins targeted by the engineered receptors, enabling the formation of escape variants that elude CAR T cell targeting...
April 24, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28436911/sampled-data-fuzzy-control-for-nonlinear-coupled-parabolic-pde-ode-systems
#7
Zi-Peng Wang, Huai-Ning Wu, Han-Xiong Li
In this paper, a sampled-data fuzzy control problem is addressed for a class of nonlinear coupled systems, which are described by a parabolic partial differential equation (PDE) and an ordinary differential equation (ODE). Initially, the nonlinear coupled system is accurately represented by the Takagi-Sugeno (T-S) fuzzy coupled parabolic PDE-ODE model. Then, based on the T-S fuzzy model, a novel time-dependent Lyapunov functional is used to design a sampled-data fuzzy controller such that the closed-loop coupled system is exponentially stable, where the sampled-data fuzzy controller consists of the ODE state feedback and the PDE static output feedback under spatially averaged measurements...
April 17, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28436865/video-anomaly-detection-with-compact-feature-sets-for-online-performance
#8
Roberto Leyva, Victor Sanchez, Chang-Tsun Li
Over the past decade, video anomaly detection has been explored with remarkable results. However, research on methodologies suitable for online performance is still very limited. In this paper, we present an online framework for video anomaly detection. The key aspect of our framework is a compact set of highly descriptive features, which is extracted from a novel cell structure that helps to define support regions in a coarse-to-fine fashion. Based on the scene's activity, only a limited number of support regions are processed, thus limiting the size of the feature set...
April 18, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28436735/risk-and-safety-perception-on-urban-and-rural-roads-effects-of-environmental-features-driver-age-and-risk-sensitivity
#9
Jolene A Cox, Vanessa Beanland, Ashleigh J Filtness
OBJECTIVE: The ability to detect changing visual information is a vital component of safe driving. In addition to detecting changing visual information, drivers must also interpret its relevance to safety. Environmental changes considered to have high safety relevance will likely demand greater attention and more timely responses than those considered to have lower safety relevance. The aim of the present study was to explore factors that are likely to influence perceptions of risk and safety regarding changing visual information in the driving environment...
February 21, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28435724/crystal-structures-of-two-platinum-ii-complexes-containing-ethyl-eugenoxyacetate-and-2-amino-pyridine
#10
Hai Le Thi Hong, Thao Nguyen Thu, Hien Nguyen, Luc Van Meervelt
In the title complexes, trans-(2-amino-pyridine-κN)di-chlorido-{4-eth-oxy-carbonyl-meth-oxy-3-meth-oxy-1-[(2,3-η)-prop-2-en-1-yl]benzene}-platinum(II), [PtCl2(C5H6N2)(C14H18O4)], (I), and (2-amino-pyridine-κN)chlorido{5-eth-oxy-car-bon-yl-meth-oxy-4-meth-oxy-1-[(2,3-η)-prop-2-en-1-yl]phenyl-κC(1)}-platinum(II), [Pt(C14H17O4)Cl(C5H6N2)], (II), the central Pt(II) metal atom displays a distorted square-planar coordination, with the Pt(II) atom coordinated by the pyridine N atom, the C=C double bond of the eugenol ligand and two Cl atoms for (I) or one Cl atom and a C atom of the phenyl ring for (II)...
April 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28435281/first-do-no-harm-institutional-betrayal-and-trust-in-health-care-organizations
#11
Carly Parnitzke Smith
PURPOSE: Patients' trust in health care is increasingly recognized as important to quality care, yet questions remain about what types of health care experiences erode trust. The current study assessed the prevalence and impact of institutional betrayal on patients' trust and engagement in health care. PARTICIPANTS AND METHODS: Participants who had sought health care in the US in October 2013 were recruited from an online marketplace, Amazon's Mechanical Turk. Participants (n = 707; 73% Caucasian; 56...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28434384/a-healthbot-future-utopian-dystopian-distraction
#12
Carly Dakin
No abstract text is available yet for this article.
January 2017: Journal of Visual Communication in Medicine
https://www.readbyqxmd.com/read/28434382/the-bma-patient-information-awards-what-s-the-history
#13
Carly Dakin
The British Medical Association (BMA) Patient Information Awards has been running since 1997. This article briefly looks back at it's history and origins.
January 2017: Journal of Visual Communication in Medicine
https://www.readbyqxmd.com/read/28434148/advancing-chimeric-antigen-receptor-t-cell-therapy-with-crispr-cas9
#14
REVIEW
Jiangtao Ren, Yangbing Zhao
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (CRISPR/Cas9) system, an RNA-guided DNA targeting technology, is triggering a revolution in the field of biology. CRISPR/Cas9 has demonstrated great potential for genetic manipulation. In this review, we discuss the current development of CRISPR/Cas9 technologies for therapeutic applications, especially chimeric antigen receptor (CAR) T cell-based adoptive immunotherapy. Different methods used to facilitate efficient CRISPR delivery and gene editing in T cells are compared...
April 22, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28434147/increasing-the-safety-and-efficacy-of-chimeric-antigen-receptor-t-cell-therapy
#15
REVIEW
Hua Li, Yangbing Zhao
Chimeric antigen receptor (CAR) T cell therapy is a promising cancer treatment that has recently been undergoing rapid development. However, there are still some major challenges, including precise tumor targeting to avoid off-target or "on-target/off-tumor" toxicity, adequate T cell infiltration and migration to solid tumors and T cell proliferation and persistence across the physical and biochemical barriers of solid tumors. In this review, we focus on the primary challenges and strategies to design safe and effective CAR T cells, including using novel cutting-edge technologies for CAR and vector designs to increase both the safety and efficacy, further T cell modification to overcome the tumor-associated immune suppression, and using gene editing technologies to generate universal CAR T cells...
April 22, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28433773/who-s-calling-social-networks-and-mobile-phone-use-among-motorcyclists
#16
Chris De Gruyter, Long T Truong, Hang T T Nguyen
Mobile phone use while riding a motorcycle poses a key safety risk, particularly among younger people who have been found to be more susceptible to distracted driving. While previous research has examined the influence of social networks on mobile phone use while driving a car, no research has explored this association in the context of motorcycle use. Using a survey of university students in Vietnam, this research explores the association between social networks and mobile phone use among motorcyclists and the links this has to reported crashes/falls...
April 20, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28433515/understanding-clinical-development-of-chimeric-antigen-receptor-t-cell-therapies
#17
Sofieke de Wilde, Henk-Jan Guchelaar, Maarten Laurens Zandvliet, Pauline Meij
BACKGROUND AIMS: In the past decade, many clinical trials with gene- and cell-based therapies (GCTs) have been performed. Increased interest in the development of these drug products by various stakeholders has become apparent. Despite this growth in clinical studies, the number of therapies receiving marketing authorization approval (MAA) is lagging behind. To enhance the success rate of GCT development, it is essential to better understand the clinical development of these products...
April 19, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28433402/sensing-bad-are-co-stimulatory-car-expressing-%C3%AE-%C3%AE-t-cells-safer
#18
Robin Parihar
No abstract text is available yet for this article.
April 19, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28433201/humoral-primary-immunodeficiency-diseases-clinical-overview-and-chest-high-resolution-computed-tomography-hrct-features-in-the-adult-population
#19
REVIEW
L Cereser, R Girometti, P d'Angelo, M De Carli, A De Pellegrin, C Zuiani
Humoral primary immunodeficiency diseases (hPIDs) are a heterogeneous group of hereditary disorders resulting in abnormal susceptibility to infections of the sinopulmonary tract. Some of these conditions (e.g., common variable immunodeficiency disorders [CVID]) imply a number of non-infectious thoracic complications such as non-infectious airway disorders, diffuse lung parenchymal diseases, and neoplasms. Chest high-resolution computed tomography (HRCT) is a key imaging tool to characterise and quantify the extent of underlying thoracic involvement, as well as to direct and monitor treatment...
April 19, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28432614/dual-activity-of-hydroxypropyl-%C3%AE-cyclodextrin-and-water-soluble-carriers-on-the-solubility-of-carvedilol
#20
Abdelmoumin Zoghbi, Tianjiao Geng, Bo Wang
Carvedilol (CAR) is a non-selective α and β blocker categorized as class II drug with low water solubility. Several recent studies have investigated ways to overcome this problem. The aim of the present study was to combine two of these methods: the inclusion complex using hydroxypropyl-β-cyclodextrin (HPβCD) with solid dispersion using two carriers: Poloxamer 188 (PLX) and Polyvinylpyrrolidone K-30 (PVP) to enhance the solubility, bioavailability, and the stability of CAR. Kneading method was used to prepare CAR-HPβCD inclusion complex (KD)...
April 21, 2017: AAPS PharmSciTech
keyword
keyword
10800
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"