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https://www.readbyqxmd.com/read/28920811/salt-bath-as-a-treatment-for-idiopathic-dermatitis-in-captive-nile-hippopotamus-hippopotamus-amphibius
#1
Kelly E Helmick
Ulcerative skin lesions were observed in two captive adult female hippos (Hippopotamus amphibius) from a zoological collection. Lesions appeared as cracking, peeling, or vesicles of the skin affecting the lateral and ventral aspects of the neck, limbs, thorax, and abdomen, dorsum, toes, and perineal region. Some lesions drained blood, serum, or purulent material. Histologic evaluation of sloughed skin consisted of deep dermal collagen with bacterial cellulitis and vasculitis and superficial fungal colonization...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28913873/improvement-of-decellularization-efficiency-of-porcine-aorta-using-dimethyl-sulfoxide-as-a-penetration-enhancer
#2
Selcan Guler, Halil M Aydin, Lan-Xin Lü, Ying Yang
Decellularization of tissues and organs enables researchers to obtain extracellular matrix (ECM) with the natural conformation and chemical composition of specific tissues. However, drawbacks exist such as the structural alteration of ECM or loss of some important components in ECM due to overexposure to chemicals during the decellularization process. In this study, porcine aorta was decellularized by sodium dodecyl sulfate (SDS). Dimethyl sulfoxide (DMSO) was used as a penetration enhancer in the decellularization process to enhance the penetration of SDS, consequently reducing the exposure time of SDS to treated tissues...
September 15, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28875112/bilateral-corneal-perforation-due-to-mrsa-keratitis-in-a-crosslinking-patient
#3
Zackery Oakey, Kevin Thai, Sumit Garg
Introduction: The cornea may become infected and perforated after epithelium-on collagen crosslinking. Case presentation: A healthy 33-year-old male who underwent corneal collagen crosslinking in both eyes developed a purulent keratitis and bilateral corneal perforations, requiring bilateral penetrating keratoplasties. He was exposed to methicillin resistant staphylococcus aureus (MRSA) by a family member with a tracheostomy and was treated with MRSA-directed antibiotics. After prolonged recovery and treatment of his infection, he had acceptable but limited uncorrected visual acuity, with excellent corrected visual acuity...
2017: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/28865450/elution-kinetics-of-vancomycin-and-gentamicin-from-carriers-and-their-effects-on-mesenchymal-stem-cell-proliferation-an-in-vitro-study
#4
Tomas Kucera, Lenka Ryskova, Tomas Soukup, Jana Malakova, Eva Cermakova, Pavel Mericka, Jakub Suchanek, Pavel Sponer
BACKGROUND: Musculoskeletal infections remain a major complication in orthopedic surgery. The local delivery of antibiotics provides the high levels required to treat an infection without systemic toxicity. However, the local toxicity of antibiotic carriers to the mesenchymal stem cells, as a result of both the peak concentrations and the type of carrier, may be significant. METHODS: To address this concern, the elution kinetics of vancomycin and gentamicin from several commercially available antibiotic carriers and several carriers impregnated by a surgeon (10 ml of each sterile carrier were manually mixed with a 500 mg vancomycin and an 80 mg gentamicin solution, and the duration of impregnation was 30 min) were assessed...
September 2, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28807566/electrospun-collagen-based-nanofibres-a-sustainable-material-for-improved-antibiotic-utilisation-in-tissue-engineering-applications
#5
Ivan J Hall Barrientos, Eleonora Paladino, Peter Szabó, Sarah Brozio, Peter J Hall, Charles I Oseghale, Melissa K Passarelli, Susan J Moug, Richard A Black, Clive G Wilson, Romana Zelkó, Dimitrios A Lamprou
For the creation of scaffolds in tissue engineering applications, it is essential to control the physical morphology of fibres and to choose compositions which do not disturb normal physiological function. Collagen, the most abundant protein in the human body, is a well-established biopolymer used in electrospinning compositions. It shows high in-vivo stability and is able to maintain a high biomechanical strength over time. In this study, the effects of collagen type I in polylactic acid-drug electrospun scaffolds for tissue engineering applications are examined...
August 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28804554/effect-of-omiganan-on-colonic-anastomosis-healing-in-a-rat-model-of-peritonitis
#6
Teresa Lorenzi, Maria Michela Cappelletti Trombettoni, Roberto Ghiselli, Francesca Paolinelli, Rosaria Gesuita, Oscar Cirioni, Mauro Provinciali, Wojciech Kamysz, Elzbieta Kamysz, Cristiano Piangatelli, Mario Castellucci Md, Mario Guerrieri, Manrico Morroni
BACKGROUND: This study investigates the effects of the antimicrobial cationic peptide omiganan-alone and combined with the antibiotic imipenem-on colonic anastomosis healing in presence of intraperitoneal sepsis induced in a rodent model of cecal ligation and puncture (CLP). METHODS: Forty male Wistar rats were divided into 5 groups of 8 animals. Group 1 (control group) underwent laparotomy and cecal mobilization and the next day received left colon anastomosis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28795395/modulation-of-periodontitis-progression-using-ph-responsive-nanosphere-encapsulating-metronidazole-or-n-phenacylthialzolium-bromide
#7
J-H Lin, F Feng, M-C Yu, C-H Wang, P-C Chang
BACKGROUND AND OBJECTIVE: This study aimed to develop pH-responsive polylactide-glycolic acid co-polymer and chitosan (PLGA/chitosan) nanosphere as an inflammation-responsive vehicle and evaluate the potential of the nanosphere encapsulating metronidazole, an antibiotic, and N-phenacylthiazolium bromide (PTB), a host modulator, for treating periodontitis. MATERIAL AND METHODS: PLGA/chitosan nanospheres were fabricated using oil-in-water emulsion method. Experimental periodontitis was induced on the rat maxillae, and the sites were randomly allocated to four treatment categories, including periodontitis alone (PR), periodontitis with nanospheres alone, nanospheres encapsulating metronidazole (MT) and nanospheres encapsulating PTB (PB)...
August 10, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28766808/investigation-of-the-regenerative-potential-of-necrotic-mature-teeth-following-different-revascularisation-protocols
#8
Sarah Hossam Fahmy, Ehab El Sayed Hassanien, Mohamed Mokhtar Nagy, Kariem Mostafa El Batouty, Mohamed Mekhemar, Karim Fawzy El Sayed, El Hassan Hassanein, Jörg Wiltfang, Christof Dörfer
This study aimed to assess the revascularisation potential of necrotic mature teeth in a dog model following different protocols. Periapical infection was induced in 54 mature premolars. Teeth were distributed into seven groups: (1) Double-antibiotic-paste/Blood clot, (2) Ciprofloxacin/collagen, (3) Double-antibiotic-paste/Collagen, (4) Modified Tri-antibiotic-paste /collagen, (5) Ciprofloxacin/Gelfoam, (6) Double-antibiotic-paste/Gelfoam, and (7) Modified Triantibiotic- paste/Gelfoam. Positive and negative controls included infected and healthy teeth, respectively, (n = 12 roots/group)...
August 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/28762193/probiotic-features-of-lactic-acid-bacteria-isolated-from-a-diverse-pool-of-traditional-greek-dairy-products-regarding-specific-strain-host-interactions
#9
Georgia Zoumpopoulou, Alexandra Tzouvanou, Eleni Mavrogonatou, Voula Alexandraki, Marina Georgalaki, Rania Anastasiou, Marina Papadelli, Eugenia Manolopoulou, Maria Kazou, Dimitris Kletsas, Konstantinos Papadimitriou, Effie Tsakalidou
The increased consumers' interest on the positive role of food in wellbeing and health underscores the need to determine new probiotic microorganisms. Triggered by the fact that artisanal food products can be a valuable source of novel probiotic strains, 106 lactic acid bacteria, all isolated from traditional Greek dairy products, namely Feta, Kasseri, Xynotyri, Graviera, Formaela, Galotyri, and Kefalotyri cheeses as well as yogurt and milk, were studied for probiotic properties. Based on their survival at pH 2...
July 31, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28759425/managing-cutaneous-tuberculosis-a-case-report
#10
Bettina M Brown-Gallardo
Tuberculosis (TB) continues to be a prevalent disease worldwide; an estimated one third of the world's population is infected and 2015 data from the World Health Organization show 10 million people had an active infection. Although TB often is cited as a disease that most commonly occurs in underdeveloped countries, the evolution of drug-resistant forms of TB and infection sensitivity of immunocompromised individuals have made this disease a focal point for indus- trialized countries as well. When TB is spread, it commonly affects the lungs, but it can infect any organ of the body...
July 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28739721/a-preclinical-study-of-cell-seeded-tubularized-scaffolds-specially-secreting-ll37-for-reconstruction-of-long-urethral-defects
#11
Yongwei Li, Jitao Wu, Fan Feng, Changping Men, Diandong Yang, Zhenli Gao, Zhe Zhu, Yuanshan Cui, Hongwei Zhao
AIM: We constructed a new artificial, long tubular acellular matrix, seeded with autologous progenitor cells transfected with the sequence to produce the antibiotic peptide LL37 and another two common seeding cells, which might be adopted for patients requiring repair of long segment of the urethra. MATERIALS AND METHODS: Autologous endothelial progenitor cells transfected by lentiviral vectors expressing antibiotic peptide LL37, as well as urothelial and smooth muscle cells from New Zealand white male rabbits, were cultured and seeded onto preconfigured acellular collagen-based tubular matrices (3 cm in length)...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28732837/immune-diffuse-alveolar-hemorrhage-clinical-presentation-and-outcome
#12
Silvia Quadrelli, Diana Dubinsky, Marco Solis, Demelza Yucra, Marcos Hernández, Hugo Karlen, Alejandro Brigante
BACKGROUND: Diffuse alveolar haemorrhage (DAH) is a manifestation of several immune and nonimmune diseases. OBJECTIVE: The objective of this study was to characterize the clinical characteristics and short-term outcomes of patients with immune-mediated DAH requiring hospital admission. METHODS: A retrospective study from December 2010 to December 2015, was conducted by analyzing the clinical records of 39 patients with DAH with a proven immunological origin...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28710882/mid-trimester-preterm-premature-rupture-of-membranes-pprom-etiology-diagnosis-classification-international-recommendations-of-treatment-options-and-outcome
#13
REVIEW
Michael Tchirikov, Natalia Schlabritz-Loutsevitch, James Maher, Jörg Buchmann, Yuri Naberezhnev, Andreas S Winarno, Gregor Seliger
Mid-trimester preterm premature rupture of membranes (PPROM), defined as rupture of fetal membranes prior to 28 weeks of gestation, complicates approximately 0.4%-0.7% of all pregnancies. This condition is associated with a very high neonatal mortality rate as well as an increased risk of long- and short-term severe neonatal morbidity. The causes of the mid-trimester PPROM are multifactorial. Altered membrane morphology including marked swelling and disruption of the collagen network which is seen with PPROM can be triggered by bacterial products or/and pro-inflammatory cytokines...
July 15, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28701192/protection-of-farm-goats-by-combinations-of-recombinant-peptides-and-formalin-inactivated-spores-from-a-lethal-bacillus-anthracis-challenge-under-field-conditions
#14
Susanne M Koehler, Fatih Buyuk, Ozgur Celebi, Hayati Demiraslan, Mehmet Doganay, Mitat Sahin, Jens Moehring, Okechukwu C Ndumnego, Salih Otlu, Henriette van Heerden, Wolfgang Beyer
BACKGROUND: Bacillus (B.) anthracis, the causal agent of anthrax, is effectively controlled by the Sterne live spore vaccine (34F2) in animals. However, live spore vaccines are not suitable for simultaneous vaccination and antibiotic treatment of animals being at risk of infection in an outbreak situation. Non-living vaccines could close this gap. RESULTS: In this study a combination of recombinant protective antigen and recombinant Bacillus collagen-like antigen (rBclA) with or without formalin inactivated spores (FIS), targeted at raising an immune response against both the toxins and the spore of B...
July 12, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28698997/zinc-oxide-curcumin-nanocomposite-loaded-collagen-membrane-as-an-effective-material-against-methicillin-resistant-coagulase-negative-staphylococci
#15
K R Soumya, S Snigdha, Sheela Sugathan, Jyothis Mathew, E K Radhakrishnan
Zinc oxide nanoparticles and curcumin are excellent antimicrobial agents. They have the potential to be used as alternative to antibiotics in wound infection management. In this study, ZnO-curcumin nanocomposite was synthesized and characterized. Physical adsorption of the nanocomposite onto collagen skin wound dressing was conducted and structural investigation was carried out by SEM. Antimicrobial assay, minimum inhibitory concentration (MIC), and viability assays of different concentrations of nanocomposite loaded collagen membrane were conducted against clinically isolated methicillin-resistant coagulase-negative Staphylococci (MRCoNS), such as S...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28696234/role-of-daptomycin-on-burn-wound-healing-in-an-animal-methicillin-resistant-staphylococcus-aureus-infection-model
#16
Oriana Simonetti, Guendalina Lucarini, Fiorenza Orlando, Elisa Pierpaoli, Roberto Ghiselli, Mauro Provinciali, Pamela Castelli, Mario Guerrieri, Roberto Di Primio, Annamaria Offidani, Andrea Giacometti, Oscar Cirioni
Prolonged hospitalization and antibiotic therapy are risk factors for the development of methicillin-resistant Staphylococcus aureus (MRSA) infections in thermal burn patients. We used a rat model to study the in vivo efficacy of daptomycin in the treatment of burn wound infections by S. aureus, and we evaluated the wound healing process through morphological and immunohistochemical analysis. A copper bar heated in boiling water was applied on a paraspinal site of each rat, resulting in two full-thickness burns...
September 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28672142/how-effective-is-the-tent-screw-pole-technique-compared-to-other-forms-of-horizontal-ridge-augmentation
#17
George R Deeb, Dan Tran, Caroline K Carrico, Erin Block, Daniel M Laskin, Janina Golob Deeb
PURPOSE: The tent screw pole technique is one of the methods available for practitioners to perform horizontal ridge augmentation to facilitate dental implant placement. The purpose of this study was to evaluate the efficacy of the tent screw pole technique for horizontal ridge augmentation and to compare the results with those of the tunnel technique and open ridge augmentation. PATIENTS AND METHODS: In this retrospective cohort study, 35 patients underwent horizontal ridge augmentation with the tent screw pole technique, a 1:1 ratio of mineralized freeze-dried bone allograft and particulate bovine hydroxyapatite, and a resorbable collagen membrane...
June 13, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28665944/molecular-mechanics-of-staphylococcus-aureus-adhesin-cna-and-the-inhibition-of-bacterial-adhesion-by-stretching-collagen
#18
Ali Madani, Kiavash Garakani, Mohammad R K Mofrad
Bacterial adhesion to collagen, the most abundant protein in humans, is a critical step in the initiation and persistence of numerous bacterial infections. In this study, we explore the collagen binding mechanism of the multi-modular cell wall anchored collagen adhesin (CNA) in Staphylococcus aureus and examine how applied mechanical forces can modulate adhesion ability. The common structural-functional elements and domain organization of CNA are present across over 50 genera of bacteria. Through the use of molecular dynamics models and normal mode analysis, we shed light on the CNA's structural and conformational dynamics and its interactions with collagen that lead to collagen binding...
2017: PloS One
https://www.readbyqxmd.com/read/28664712/comparative-study-on-usefulness-of-gentamycin-containing-collagen-implants-in-the-treatment-of-patients-with-osteitis-and-osteomyelitis-of-the-craniofacial-skeleton
#19
COMPARATIVE STUDY
Paweł J Zawadzki, Konrad Perkowski, Michał Kotlarski, Anna Pietruczuk-Padzik, Lidia Chomicz
<b>Introduction and objective.</b> A reduction in incidences of peri-surgical complications due to infections is achieved by antibiotic prophylaxis The objective of the study was to assess the usefulness of gentamycin-containing collagen implants (GCCI) in the treatment of patients with osteitis and osteomyelitis of the craniofacial skeleton. <b>Materials and method.</b> The retrospective study included 103 patients with osteitis and osteomyelitis. 54 patients were treated intra-operatively with GCCI (Garamycin, EusaPharma, Europe)...
May 11, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28659548/pathogenicity-of-enterococci
#20
REVIEW
Yasuyoshi Ike
Enterococci belong to the group of lactic acid bacteria (LAB), and inhabit the gastrointestinal tracts of a wide variety of animals from insects and to human, and the commensal organism in humans and animals. The commensal/probiotic role of enterococci has evolved through thousands of years in mutual coexistence. Enterococcus have many favorable traits that have been appreciated in food fermentation and preservation, and many serve as probiotics to promote health. While lactobacillus have been shown to confer numerous benefits on and often regarded as health bringing organisms, enterococci have become more recognized as emerging human pathogens in recent years...
2017: Nihon Saikingaku Zasshi. Japanese Journal of Bacteriology
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