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https://www.readbyqxmd.com/read/27913240/activity-of-vancomycin-release-from-bioinspired-coatings-of-hydroxyapatite-or-tio2-nanotubes
#1
Daniela Ionita, Daniela Bajenaru-Georgescu, Georgeta Totea, Anca Mazare, Patrik Schmuki, Ioana Demetrescu
Herein we investigate the efficiency of various biomimetic coatings for localized drug delivery, using vancomycin as key therapeutic drug, which is a widely used antibiotic for the treatment of strong infections caused by positive Gram bacteria. We evaluate classical hydroxyapatite and biomimetic hydroxyapatite-collagen coatings obtained by electrochemical deposition as well as TiO2 nanotubes arrays obtained by electrochemical anodization. Surface morphology, compositional and structural data confirm the incorporation of vancomycin into the layers and drug release profiles for vancomycin evaluate their release ability...
November 29, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27890562/tailor-made-fibroblast-specific-and-antibiotic-free-interleukin-12-plasmid-for-gene-electrotransfer-mediated-cancer-immunotherapy
#2
Urska Kamensek, Natasa Tesic, Gregor Sersa, Spela Kos, Maja Cemazar
Electrotransfer mediated delivery of interleukin-12 (IL-12) gene, encoded on a plasmid vector, has already been demonstrated to have a potent antitumor efficacy and great potential for clinical application. In the present study, our aim was to construct an optimized IL-12-encoding plasmid that is safe from the regulatory point of view. In light of previous studies demonstrating that IL-12 should be released in a tumor localized manner for optimal efficacy, the strong ubiquitous promoter was replaced with a weak endogenous promoter of the collagen 2 gene, which is specific for fibroblasts...
November 24, 2016: Plasmid
https://www.readbyqxmd.com/read/27800687/latent-oxidative-polymerization-of-catecholamines-as-potential-crosslinkers-for-biocompatible-and-multifunctional-biopolymer-scaffolds
#3
Chetna Dhand, Veluchamy Amutha Barathi, Seow Theng Ong, Mayandi Venkatesh, Sriram Harini, Neeraj Dwivedi, Eunice Tze Leng Goh, Muruganantham Nandhakumar, Jayarama Reddy Venugopal, Silvia Marrero Diaz, Mobashar Hussain Urf Turabe Fazil, Xian Jun Loh, Liu Shou Ping, Roger W Beuerman, Navin Kumar Verma, Seeram Ramakrishna, Rajamani Lakshminarayanan
Electrospinning of naturally occurring biopolymers for biological applications requires post-spinning crosslinking for endurance in protease-rich microenvironments and prevention of rapid dissolution. The most commonly used crosslinkers often generate cytotoxic byproducts, necessitate high concentrations or time-consuming procedures. Herein, we report the addition of "safe" catecholamine crosslinkers to collagen or gelatin dope solutions followed by electrospinning yielded junction-containing nanofibrous mats...
November 1, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27769794/the-potential-role-of-amlodipine-on-experimentally-induced-bacterial-rhinosinusitis
#4
Arzu Tatar, Mukadder Korkmaz, Muhammed Yayla, Elif Polat, Hakan Uslu, Zekai Halici, Secil N Parlak
INTRODUCTION: For the treatment of rhinosinusitis antibiotics are used frequently. Concerns have been raised regarding the adverse effects of antibiotics and growing resistance. The lack of discovery of new antibiotic compounds has increased the necessity for exploration of non-antibiotic compounds that have antibacterial activity. Amlodipine is a non-antibiotic compound with anti-inflammatory activity. OBJECTIVE: In this study we aimed to investigate the potential role of amlodipine in treatment of rhinosinusitis by evaluating its effects on tissue oxidative status, mucosal histology and inflammation...
September 28, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27713677/intraoperative-anaphylactic-reaction-is-it-the-floseal
#5
Brianne Bordes, David Martin, Brian Schloss, Allan Beebe, Walter Samora, Jan Klamar, David Stukus, Joseph D Tobias
When hemodynamic or respiratory instability occurs intraoperatively, the inciting event must be determined so that a therapeutic plan can be provided to ensure patient safety. Although generally uncommon, one cause of cardiorespiratory instability is anaphylactic reactions. During anesthetic care, these most commonly involve neuromuscular blocking agents, antibiotics, or latex. Floseal is a topical hemostatic agent that is frequently used during orthopedic surgical procedures to augment local coagulation function and limit intraoperative blood loss...
July 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/27684511/constrictive-bronchiolitis-in-cystic-fibrosis-adolescents-with-refractory-pulmonary-decline
#6
William T Harris, J Todd Boyd, Gary L McPhail, Alan S Brody, Rhonda D Szczesniak, Leslie L Korbee, Michael L Baker, John P Clancy
RATIONALE: Refractory lung function decline in association with recurrent pulmonary exacerbations is a common, yet poorly explained finding in cystic fibrosis (CF). To investigate the histopathologic mechanisms of pulmonary deterioration during adolescence and early adulthood, we reviewed clinically-indicated lung biopsy specimens obtained during a period of persistent decline. OBJECTIVES: To determine if peribronchiolar remodeling is prominent in lung biopsy specimens obtained in adolescents with CF refractory to conventional therapy...
December 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27677596/collagen-and-%C3%AE-tubulin-of-mouse-tympanic-membrane-fibroblasts-treated-with-quinolones-and-aminoglycosides
#7
Bailey A Milne-Davies, Patrick J Antonelli, Nicklas C Orobello, Carolyn O Dirain
OBJECTIVE: To assess collagen and α-tubulin levels of mouse tympanic membrane fibroblasts treated with quinolone and aminoglycoside antibiotics at concentrations found in eardrops. STUDY DESIGN: Prospective controlled cell culture study. SETTING: Academic tertiary medical center. SUBJECTS: Mouse tympanic membrane fibroblasts. METHODS: In experiment 1, fibroblasts were treated with the following for 24 or 48 hours: phosphate-buffered saline (negative control), dilute hydrochloric acid (positive control), 0...
September 27, 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27663174/minocycline-attenuates-cardiac-dysfunction-in-tumor-burdened-mice
#8
Raymond D Devine, Clayton M Eichenseer, Loren E Wold
Cardiovascular dysfunction as a result of tumor burden is becoming a recognized complication; however, the mechanisms remain unknown. A murine model of cancer cachexia has shown marked increases of matrix metalloproteinases (MMPs), known mediators of cardiac remodeling, in the left ventricle. The extent to which MMPs are involved in remodeling remains obscured. To this end a common antibiotic, minocycline, with MMP inhibitory properties was used to elucidate MMP involvement in tumor induced cardiovascular dysfunction...
September 20, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27620475/development-of-a-novel-collagen-wound-model-to-simulate-the-activity-and-distribution-of-antimicrobials-in-soft-tissue-during-diabetic-foot-infection
#9
Bianca L Price, Andrew M Lovering, Frank L Bowling, Curtis B Dobson
Diabetes has major implications for public health, with diabetic foot ulcers (DFUs) being responsible for significant morbidity and mortality. A key factor in the development of non-healing ulcers is infection, which often leads to the development of biofilm, gangrene and amputation. A novel approach to treating DFUs is the local release of antibiotics from calcium sulfate beads. We have developed a novel model system to study and compare the release and efficacy of antibiotics released locally, using collagen as a substrate for biofilm growth, and incorporating serum to mimic the biochemical complexity of the wound environment...
September 12, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27616281/potential-of-combination-therapy-of-endolysin-mr-10-and-minocycline-in-treating-mrsa-induced-systemic-and-localized-burn-wound-infections-in-mice
#10
Shivani Chopra, Kusum Harjai, Sanjay Chhibber
MRSA is the predominant pathogen responsible for fatal burn wound infection in patients. Antibiotic resistance and its ability to form biofilms on the surface of burn wounds limit the use of antibiotics to contain this pathogen. The results of present study have shown that single dose of combination therapy of endolysin MR-10 (50μg/s.c) and minocycline (50mg/kg/orally) resulted in 100% survival of group of mice with systemic MRSA infection. Maximum reduction in bacterial load in various organs was observed in the group that received combination therapy...
December 2016: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/27535296/intermittent-haemoptysis-due-to-an-aortobronchial-fistula-in-a-warmblood-mare
#11
H Versnaeyen, V Saey, D Vermeiren, K Chiers, R Ducatelle
A 7-year-old warmblood mare showed sudden onset of mild intermittent haemoptysis. Clinical examination revealed no significant abnormalities. Haematological examination showed mild anaemia, hypoalbuminaemia and neutrophilia. Coagulation tests were normal. Endoscopic examination revealed unilateral pulmonary haemorrhage with blood clots in the bronchi and trachea. Treatment with antibiotics was started and the horse was given stable rest. Two weeks later, the horse was found dead with blood and frothy sputum leaking from the nostrils...
August 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27498362/in%C3%A2-vivo-efficacy-of-single-phage-versus-phage-cocktail-in-resolving-burn-wound-infection-in-balb-c-mice
#12
Parul Chadha, Om Prakash Katare, Sanjay Chhibber
Klebsiella pneumoniae is one of the most predominant pathogens associated with burn wound infections, causing considerable morbidity and mortality. The indiscriminate usage of antibiotics has led to the development of resistant strains, which have contributed towards the inefficacy of antibiotics. Phage therapy is a promising alternative to hinder the progression of pathogenic bacteria. However, phage bacterial resistance is already well known but the use of phage cocktails can overcome this drawback. The aim of the study was to evaluate the therapeutic efficacy of monophage (Kpn1, Kpn2, Kpn3, Kpn4 and Kpn5) in comparison to phage cocktail in resolving the course of burn wound infection in mice...
October 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27383572/hen-s-egg-as-a-source-of-valuable-biologically-active-substances
#13
Zygmunt Zdrojewicz, Marta Herman, Ewa Starostecka
The aim of this article is to show current knowledge concerning valuable substances biologically active present in hen eggs and underline important nutritive role of hen eggs. Hen egg is a good source of nutrients such as proteins, vitamins (A, B2, B6, B12, D, E, K), minerals and lipids. The significant part of lipids is a group of unsaturated phospholipids, which are components of cell membranes, act protectively on the cardiovascular system and contribute to a decrease of cholesterol level and blood pressure...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27333161/the-signal-sequence-of-the-abundant-extracellular-metalloprotease-ppep-1-can-be-used-to-secrete-synthetic-reporter-proteins-in-clostridium-difficile
#14
Ana M Oliveira Paiva, Annemieke H Friggen, Shabnam Hossein-Javaheri, Wiep Klaas Smits
Clostridium difficile is an opportunistic pathogen and the main cause of antibiotic-associated diarrhea. Adherence of C. difficile to host cells is modulated by proteins present on the bacterial cell surface or secreted into the environment. Cleavage of collagen-binding proteins is mediated by the zinc metalloprotease PPEP-1, which was identified as one of the most abundant secreted proteins of C. difficile. Here, we exploit the PPEP-1 signal sequence to produce novel secreted enzymes. We have constructed two functional secreted reporters, AmyE(opt) and sLuc(opt) for gene expression analysis in C...
June 23, 2016: ACS Synthetic Biology
https://www.readbyqxmd.com/read/27279734/gentamicin-impregnated-collagen-sponge-effectiveness-in-preventing-sternal-wound-infection-in-high-risk-cardiac-surgery
#15
REVIEW
Filippo Rapetto, Vito D Bruno, Gustavo Guida, Roberto Marsico, Pierpaolo Chivasso, Carlo Zebele
Sternal wound infections represent one of the most frequent complications after cardiac surgery and are associated with high postoperative mortality. Several preventive methods have been introduced, and recently, gentamicin-impregnated collagen sponges (GICSs) have shown a promising effect in reducing the incidence of this type of complications. Gentamicin is an aminoglycoside antibiotic that has been widely used to treat infections caused by multiresistant bacteria; despite its effectiveness, its systemic use carries a risk of toxicity...
2016: Drug Target Insights
https://www.readbyqxmd.com/read/27270861/cryopreservation-20-%C3%A2-c-of-feline-corneoscleral-tissue-histologic-microbiologic-and-ultrastructural-study
#16
Daniel Costa, Marta Leiva, Carolina Naranjo, José Ríos, Maria Teresa Peña
OBJECTIVE: To evaluate microbiological, histologic, and ultrastructural characteristics of short-term cryopreserved (STC) feline corneoscleral tissue (<1 year) and to compare it with long-term cryopreserved (LTC) tissue (>7 years). ANIMALS STUDIED: Twenty healthy feline globes were obtained from 2003 to 2013. PROCEDURE: After a decontamination protocol, globes were enucleated and stored at -20 °C in broad-spectrum antibiotics. Corneoscleral tissue was evaluated at different storage periods: <1 year (10 eyes) and >7 years (8 eyes)...
July 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27220229/collagen-crosslinking-in-the-management-of-microbial-keratitis
#17
Barac Ileana Ramona, Corbu Catalina, Merticariu Andrei, Stefan Daciana, Tataru Calin
OBJECTIVE: The evaluation of the efficiency of corneal cross linking in the management of corneal ulcers. METHOD: A prospective study that included 10 patients, 10 eyes, with chronic corneal ulcer, bacterial and/ or fungal. The patients were divided into two groups. Group A included 5 patients with unperforated corneal ulcer and group B included 5 patients with perforated corneal ulcer. These patients were treated with general and local antibiotic and antifungal drugs, but the response was poor after two weeks...
January 2016: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27218225/uropathogenic-escherichia-coli-causes-fibrotic-remodelling-of-the-epididymis
#18
Vera Michel, Yonggang Duan, Elke Stoschek, Sudhanshu Bhushan, Ralf Middendorff, Julia M Young, Kate L Loveland, David M De Kretser, Mark P Hedger, Andreas Meinhardt
Despite antibiotic treatment, up to 40% of patients have impaired fertility after epididymitis due to serovars of Escherichia coli, a frequent pathogen. The reasons for infertility are unclear, but it may result from epididymal duct obstruction. To determine whether E. coli infection of the epididymis causes obstruction due to fibrosis, and to identify the key mediators, tissues from patients with epididymitis were assessed. Additionally, epididymitis was induced with uropathogenic E. coli (UPEC) or commensal serovars in wild-type and MyD88(-/-) mice, which are relatively unresponsive to bacterial pathogens...
September 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27163295/natural-marine-sponges-for-bone-tissue-engineering-the-state-of-art-and-future-perspectives
#19
Renata Neves Granito, Márcio Reis Custódio, Ana Claudia Muniz Rennó
Marine life and its rich biodiversity provide a plentiful resource of potential new products for the society. Remarkably, marine organisms still remain a largely unexploited resource for biotechnology applications. Among them, marine sponges are sessile animals from the phylum Porifera dated at least from 580 million years ago. It is known that molecules from marine sponges present a huge therapeutic potential in a wide range of applications mainly due to its antitumor, antiviral, anti-inflammatory, and antibiotic effects...
May 10, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27151924/intestinal-dysbiosis-barrier-dysfunction-and-bacterial-translocation-account-for-ckd-related-systemic-inflammation
#20
Kirstin Andersen, Marie Sophie Kesper, Julian A Marschner, Lukas Konrad, Mi Ryu, Santhosh Kumar Vr, Onkar P Kulkarni, Shrikant R Mulay, Simone Romoli, Jana Demleitner, Patrick Schiller, Alexander Dietrich, Susanna Müller, Oliver Gross, Hans-Joachim Ruscheweyh, Daniel H Huson, Bärbel Stecher, Hans-Joachim Anders
CKD associates with systemic inflammation, but the underlying cause is unknown. Here, we investigated the involvement of intestinal microbiota. We report that collagen type 4 α3-deficient mice with Alport syndrome-related progressive CKD displayed systemic inflammation, including increased plasma levels of pentraxin-2 and activated antigen-presenting cells, CD4 and CD8 T cells, and Th17- or IFNγ-producing T cells in the spleen as well as regulatory T cell suppression. CKD-related systemic inflammation in these mice associated with intestinal dysbiosis of proteobacterial blooms, translocation of living bacteria across the intestinal barrier into the liver, and increased serum levels of bacterial endotoxin...
May 5, 2016: Journal of the American Society of Nephrology: JASN
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