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https://www.readbyqxmd.com/read/29785265/a-randomized-controlled-trial-of-the-safety-and-efficacy-of-a-topical-gentamicin-collagen-sponge-in-diabetic-patients-with-a-mild-foot-ulcer-infection
#1
Ilker Uçkay, Benjamin Kressmann, Sébastien Di Tommaso, Marina Portela, Heba Alwan, Hubert Vuagnat, Sophie Maître, Christophe Paoli, Benjamin A Lipsky
Objectives: The initial phase of infection of a foot ulcer in a person with diabetes is often categorized as mild. Clinicians usually treat these infections with antimicrobial therapy, often applied topically. Some experts, however, believe that mild diabetic foot ulcer infections will usually heal with local wound care alone, without antimicrobial therapy or dressings. Methods: To evaluate the potential benefit of treatment with a topical antibiotic, we performed a single-center, investigator-blinded pilot study, randomizing (1:1) adult patients with a mild diabetic foot ulcer infection to treatment with a gentamicin-collagen sponge with local care versus local care alone...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29780785/an-extremely-rare-case-of-hand-prolapse-with-preterm-premature-rupture-in-the-membrane-of-one-twin
#2
Minji Kim, Hye-Joo Lee, Suk-Joo Choi, Soo-Young Oh, Cheong-Rae Roh, Jong-Hwa Kim
The latency in preterm premature rupture of membranes (PPROM) can last for weeks. We describe an extremely rare case of hand prolapse with PPROM that was exposed for 23 days before delivery. The patient had spontaneous PPROM of twin A at 21.4 weeks of gestation with shoulder presentation. The right arm of the fetus eventually protruded out the vagina and the hand was exposed for extended period of time of 23 days until delivery. Daily dressing by applying collagen to dry skin and silicone to keep moisture was done to the protruding hand to prevent dehydration and desquamation of the skin...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29708273/a-case-of-feline-gastrointestinal-eosinophilic-sclerosing-fibroplasia-limited-to-the-mesentery
#3
N Kambe, R Okabe, H Osada, M Ogawa, M Kishimoto, R Fukushima, H Kondo, K Ohmori
An entire, female, mixed-breed cat of unknown age was presented with a 6-week history of lethargy, anorexia and vomiting. There was an increase in the number of white blood cells in the blood, including neutrophils and eosinophils; moderate anaemia; ascites; and possible mesenteric peritonitis. Exploratory laparotomy revealed firm, multifocal small nodules in the mesentery. As the nodules were surgically unresectable, they were biopsied. Histologically, the nodules were composed of thin trabeculae of dense collagen fibres mixed with plump fibroblasts and numerous eosinophils, consistent with feline gastrointestinal eosinophilic sclerosing fibroplasia...
April 30, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29698291/csa-90-promotes-bone-formation-and-mitigates-methicillin-resistant-staphylococcus-aureus-infection-in-a-rat-open-fracture-model
#4
Rebecca Mills, Tegan L Cheng, Kathy Mikulec, Lauren Peacock, David Isaacs, Carl Genberg, Paul B Savage, David G Little, Aaron Schindeler
BACKGROUND: Infection of open fractures remains a significant cause of morbidity and mortality to patients worldwide. Early administration of prophylactic antibiotics is known to improve outcomes; however, increasing concern regarding antimicrobial resistance makes finding new compounds for use in such cases a pressing area for further research. CSA-90, a synthetic peptidomimetic compound, has previously demonstrated promising antimicrobial action against Staphylococcus aureus in rat open fractures...
April 24, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29683273/micelle-coated-hierarchically-structured-nanofibers-with-dual-release-capability-for-accelerated-wound-healing-and-infection-control
#5
Victoria Albright, Meng Xu, Anbazhagan Palanisamy, Jun Cheng, Mary Stack, Beilu Zhang, Arul Jayaraman, Svetlana A Sukhishvili, Hongjun Wang
Tailoring nanofibrous matrices-a material with much promise for wound healing applications-to simultaneously mitigate bacterial colonization and stimulate wound closure of infected wounds is highly desirable. To that end, a dual-releasing, multiscale system of biodegradable electrospun nanofibers coated with biocompatible micellar nanocarriers is reported. For wound healing, transforming growth factor-β1 is incorporated into polycaprolactone/collagen (PCL/Coll) nanofibers via electrospinning and the myofibroblastic differentiation of human dermal fibroblasts is locally stimulated...
April 23, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29677546/bacitracin-promotes-osteogenic-differentiation-of-human-bone-marrow-mesenchymal-stem-cells-by-stimulating-the-bone-morphogenetic-protein-2-smad-axis
#6
Hui Li, Bin'en Nie, Zhe Du, Shutao Zhang, Teng Long, Bing Yue
Bacitracin, a widely used metallopeptide antibiotic, has been reported to be locally used in treating wounds without systemic adverse reactions. Our preliminary study showed that bacitracin might enhance the osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMSCs). The present study investigated whether bacitracin affects the osteogenic differentiation of HBMSCs and the molecular mechanisms involved. The proliferation of HBMSCs in the presence of bacitracin was examined using a cell counting kit-8 (CCK-8) assay...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29658991/novel-de-novo-synthesized-phosphate-carrier-compound-aba-peg20k-pi20-suppresses-collagenase-production-in-enterococcus-faecalis-and-prevents-colonic-anastomotic-leak-in-an-experimental-model
#7
M Wiegerinck, S K Hyoju, J Mao, A Zaborin, C Adriaansens, E Salzman, N H Hyman, O Zaborina, H van Goor, J C Alverdy
BACKGROUND: Previous work has demonstrated that anastomotic leak can be caused by collagenolytic bacteria such as Enterococcus faecalis via an effect on wound collagen. In humans, E. faecalis is the organism cultured most commonly from a leaking anastomosis, and is not routinely eliminated by standard oral or intravenous antibiotics. Novel strategies are needed to contain the virulence of this pathogen when present on anastomotic tissues. METHODS: Polyphosphorylated polymer ABA-PEG20k-Pi20 was tested in mice for its ability to prevent anastomotic leak caused by collagenolytic E...
April 16, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29644315/limb-salvage-and-reconstruction-following-a-zebra-attack
#8
Jacob T Carlson, James C Yuen, Matthew R Smeds
Animal bites are fairly rare events but can cause devastating traumatic injuries to the victim. In addition to the soft tissue, vascular, and orthopedic trauma inflicted by these occurrences, bite injuries also have the potential to introduce an inoculum of microbes, which may progress to an infection if not treated properly and expeditiously. We present the case of a healthy male who sustained multiple bite wounds from a domestic zebra to his left upper extremity. This attack caused severe damage, including devascularization of the arm at the brachial artery, disruption of the distal biceps and brachialis, stripping of the forearm nerves, and shearing of the overlying soft tissue...
June 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29628998/role-of-streptococcus-mutans-surface-proteins-for-biofilm-formation
#9
REVIEW
Michiyo Matsumoto-Nakano
Streptococcus mutans has been implicated as a primary causative agent of dental caries in humans. An important virulence property of the bacterium is its ability to form biofilm known as dental plaque on tooth surfaces. In addition, this organism also produces glucosyltransferases, multiple glucan-binding proteins, protein antigen c, and collagen-binding protein, surface proteins that coordinate to produce dental plaque, thus inducing dental caries. Bacteria utilize quorum-sensing systems to modulate environmental stress responses...
February 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29623705/centella-asiatica-centellicum%C3%A2-facilitates-the-regular-healing-of-surgical-scars-in-subjects-at-high-risk-of-keloids
#10
Roberto Cotellese, Shu Hu, Gianni Belcaro, Andrea Ledda, Beatrice Feragalli, Mark Dugall, Morio Hosoi, Edmondo Ippolito
BACKGROUND: Formation of scars after surgical incisions requires the proper appositions of elements contributing to the scarring process. The structural rebuilding of damaged tissues is essential in producing a linear scar. The excess of blood, foreign particles, exuberant sutures, necrotic tissue, possible infective agents, as well as the ongoing inflammatory process may produce a non-linear, sometimes painful keloidal scar. Centella asiatica (CA) extracts have been used topically since ancient times for preventing keloids (i...
April 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29602957/nanotechnology-the-scope-and-potential-applications-in-orthopedic-surgery
#11
EDITORIAL
Ashok Gavaskar, D Rojas, F Videla
Nanotechnology involves manipulation of matter measuring 1-100 nm in at least one of its dimensions at the molecular level. Engineering and manipulation of matter at the molecular level has several advantages in the field of medicine (nanomedicine) since most of the biological molecules exist and function at a nanoscale. Though promising, questions still remain on how much of this will ultimately translate into achieving better patient care. Concerns of cost-effectiveness and nanotechnology safety still remain unclear...
March 30, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29596598/a-survey-of-practice-and-opinions-on-the-use-of-topical-antibiotics-to-prevent-surgical-site-infection-more-confusion-than-consensus
#12
Charlotte Cooper, Carolyne Horner, Gavin Barlow, Jan Stryja, Kylie Sandy-Hodgetts, Tracey Guise, Hilary Humphreys
Background: Surgical site infection (SSI) is one of the most common causes of healthcare-associated infection. Although the use of topical antibiotics to prevent SSI is not recommended by current guidelines, published studies document conflicting results and conclusions. Objectives: The objectives of this survey were to: (i) determine the extent of the use of topical antibiotics to prevent SSI in clinical practice; and (ii) gather the opinions of healthcare professionals most likely to be involved in their use...
March 27, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29596530/establishment-and-characterization-of-pygmy-killer-whale-feresa-attenuata-dermal-fibroblast-cell-line
#13
Sun Yajing, Imran Rashid Rajput, Huang Ying, Yu Fei, Edmond Sanganyado, Li Ping, Wang Jingzhen, Liu Wenhua
The pygmy killer whale (Feresa attenuata) (PKW) is a tropical and subtropical marine mammal commonly found in the Atlantic, Indian and Pacific oceans. Since the PKWs live in offshore protected territories, they are rarely seen onshore. Hence, PKW are one of the most poorly understood oceanic species of odontocetes. The dermal tissue comes primarily from stranding events that occur along the coast of the Shantou, Guangdong, China. The sampled tissues were immediately processed and attached on collagen-coated 6-well tissue culture plate...
2018: PloS One
https://www.readbyqxmd.com/read/29594793/sterile-keratitis-after-uneventful-corneal-collagen-cross-linking-in-a-patient-with-axenfeld-rieger-syndrome
#14
Betul Seher Uysal, Derya Yaman, Ozge Sarac, Emine Akcay, Nurullah Cagil
PURPOSE: To report on a keratoconus (KC) patient with Axenfeld-Rieger syndrome (ARS) who developed sterile keratitis after accelerated corneal collagen cross-linking (CXL). METHODS: An 18-year-old patient with ARS and KC who had previously undergone intrastromal ring segment implantation underwent accelerated CXL (9 mW/cm2  UVA intensity for 10 min). RESULTS: After uneventful surgery, the patient presented with severe photophobia, redness of the eye, and decreased vision 72 h following the procedure...
March 28, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29534332/modulation-of-inflammatory-arthritis-by-gut-microbiota-through-mucosal-inflammation-and-autoantibody-generation
#15
Widian K Jubair, Jason D Hendrickson, Erin L Severs, Hanna M Schulz, Sumitra Adhikari, Diana Ir, Jose Pagan, Robert Anthony, Charles E Robertson, Daniel N Frank, Nirmal K Banda, Kristine A Kuhn
OBJECTIVE: Observations of microbial dysbiosis in patients with RA have raised interest in studying microbial-mucosal interactions as a potential trigger of RA. Using the murine collagen-induced arthritis (CIA) model, we hypothesized that microbiota modulate immune responses leading to autoimmune arthritis. METHODS: CIA was induced by immunization of mice with type II collagen (CII) in adjuvant on days 0 and 21, with arthritis appearing at days 23-24. Intestinal microbiota were profiled by 16S rRNA sequencing every 7 days during the course of CIA, and intestinal mucosal changes evaluated on days 14 and 35...
March 13, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29494239/2-oxoglutarate-dependent-oxygenases
#16
Md Saiful Islam, Thomas M Leissing, Rasheduzzaman Chowdhury, Richard J Hopkinson, Christopher J Schofield
2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations proceeding via hydroxylation; in plants and microbes, they catalyze a wider range including ring formations, rearrangements, desaturations, and halogenations. The catalytic flexibility of 2OGXs is reflected in their biological functions. After pioneering work identified the roles of 2OGXs in collagen biosynthesis, research indicated they also function in plant and animal development, transcriptional regulation, nucleic acid modification/repair, fatty acid metabolism, and secondary metabolite biosynthesis, including of medicinally important antibiotics...
March 1, 2018: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/29487815/trabeculectomy-with-ologen-implant-versus-mitomycin-c-in-congenital-glaucoma-secondary-to-sturge-weber-syndrome
#17
Thanaa Helmy Mohamed, Abdelrahman Gaber Salman, Riham Fawzy Elshinawy
AIM: To compare the efficacy and safety of collagen matrix implant [Ologen (OLO) implant] versus mitomycin C (MMC) with subscleral trabeculectomy (SST) for the surgical treatment of congenital glaucoma (CG) in Sturge-Weber Syndrome (SWS). METHODS: A prospective comparative randomized study of 20 eyes of 16 patients with CG associated with SWS was divided into two groups. The first group (MMC Group) included 10 eyes that were subjected to SST with MMC. The second group (OLO Group) included 10 eyes that were subjected to trabeculectomy with a collagen matrix implant (OLO implant)...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29458291/local-antibiotic-delivery-systems-current-and-future-applications-for-diabetic-foot-infections
#18
Konstantinos Markakis, Alan Robert Faris, Hamed Sharaf, Barzo Faris, Sharon Rees, Frank L Bowling
Foot infections are common among diabetic patients with peripheral neuropathy and/or peripheral arterial disease, and it can be the pivotal event leading to a minor or major amputation of the lower extremity. Treatment of diabetic foot infections, especially deep-seated ones, remains challenging, in part because impaired blood perfusion and the presence of biofilms can impair the effectiveness of systemic antibiotics. The local application of antibiotics is an emerging field in the treatment of diabetic foot infections, with demonstrable advantages...
March 2018: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29445637/virulence-determinants-and-antimicrobial-resistance-patterns-of-vancomycin-resistant-enterococcus-faecium-isolated-from-different-sources-in-southwest-iran
#19
Maniya Arshadi, Mahmood Mahmoudi, Moloud Sadat Motahar, Saber Soltani, Mohammad Reza Pourmand
Background: This study aimed to investigate the incidence of antibiotic-resistance and virulence genes in vancomycin-resistant Enterococcus faecium isolated from different sources in southwest Iran from Mar to Sep 2015. Methods: Overall, 120 E. faecium isolates (80 VRE and 40 vancomycin-susceptible enterococci [VSE] isolates) were obtained from four hospitals. The resistance of the VRE isolates was determined by disk diffusion method. Multiplex PCR was performed to detect the virulence genes carried by the E...
February 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29391259/comparative-genomics-analysis-of-clostridium-difficile-epidemic-strain-dh-nap11-106
#20
Larry K Kociolek, Dale N Gerding, David W Hecht, Egon A Ozer
Clostridium difficile PCR ribotype 106 (also identified as restriction endonuclease analysis [REA] group DH) recently emerged as the most common strain causing C. difficile infection (CDI) among US adults. We previously identified this strain predominating our pediatric cohort. Pediatric clinical CDI isolates previously characterized by REA underwent antibiotic resistance testing and whole genome sequencing. Of 134 isolates collected from children, 31 (23%) were REA group DH. We performed a comparative genomics analysis to identify DH-associated accessory genes...
April 2018: Microbes and Infection
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