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https://www.readbyqxmd.com/read/28546688/collagen-cross-linking-for-microbial-keratitis
#1
Prashant Garg, Sujata Das, Aravind Roy
Collagen cross-linking is gaining popularity not only for arresting the progression of keratoconus but also other indications including management of corneal infections. In this review article, we analyzed the published literature to understand the level of evidence for its use in corneal ulcer. Photoactivated riboflavin and ultraviolet A light are known to possess antimicrobial properties. The treatment also induces formation of inter- and intra-fibrillar bonds, thereby making the corneal collagen resistant to the action of proteases arresting stromal melt...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28508516/fell-muir-review-collagen-fibril-formation-in%C3%A2-vitro-and-in%C3%A2-vivo
#2
REVIEW
Karl E Kadler
It is a great honour to be awarded the Fell Muir Prize for 2016 by the British Society of Matrix Biology. As recipient of the prize, I am taking the opportunity to write a minireview on collagen fibrillogenesis, which has been the focus of my research for 33 years. This is the process by which triple helical collagen molecules assemble into centimetre-long fibrils in the extracellular matrix of animals. The fibrils appeared a billion years ago at the dawn of multicellular animal life as the primary scaffold for tissue morphogenesis...
May 16, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28485528/bioengineered-keratocyte-spheroids-fabricated-on-chitosan-coatings-enhance-tissue-repair-in-a-rabbit-corneal-stromal-defect-model
#3
Shih-Feng Chou, Chih-Hung Lee, Jui-Yang Lai
Cultivated cell spheroid transplantation is widely studied as a means of facilitating tissue regeneration. Chitosan biomaterial has been shown to promote keratocyte aggregation and multicellular spheroid formation. Herein, we provide further evidence on application of bioengineered keratocyte spheroids for corneal stromal tissue engineering. In an allogeneic rabbit model of stromal destruction caused by bacterial keratitis, the corneas were intrastromally injected with isolated keratocyte suspensions or aggregated spheroid grafts at same cell number...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28407169/collagen-cross-linking-with-photoactivated-riboflavin-pack-cxl-for-bacterial-keratitis-after-small-incision-lenticule-extraction-smile
#4
Tommy C Y Chan, Vanissa W S Chow, Vishal Jhanji
PURPOSE: To report a case of infectious keratitis after small incision lenticule extraction (SMILE) treated with collagen cross-linking with photoactivated riboflavin (PACK-CXL). METHODS: Case report and literature review. RESULTS: A patient presented with culture-proven bacterial keratitis 5 days after SMILE was treated with fortified topical antibiotics and PACK-CXL. Irrigation of the corneal cap-stromal bed interface, which can be difficult and affect visual outcomes, was not performed...
April 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28393762/engineering-a-functional-three-dimensional-human-cardiac-tissue-model-for-drug-toxicity-screening
#5
Hong Fang Lu, Meng Fatt Leong, Tze Chiun Lim, Ying Ping Chua, Jia Kai Lim, Chan Du, Andrew C A Wan
Cardiotoxicity is one of the major reasons for clinical drug attrition. In vitro tissue models that can provide efficient and accurate drug toxicity screening are highly desired for preclinical drug development and personalized therapy. Here, we report the fabrication and characterization of a human cardiac tissue model for high throughput drug toxicity studies. Cardiac tissues were fabricated via cellular self-assembly of human transgene-free induced pluripotent stem cells-derived cardiomyocytes in pre-fabricated polydimethylsiloxane molds...
May 11, 2017: Biofabrication
https://www.readbyqxmd.com/read/28363501/corrigendum-to-partial-depletion-of-natural-gut-flora-by-antibiotic-aggravates-collagen-induced-arthritis-cia-in-mice-pharmacol-rep-66-2014-250-255
#6
Iwona Dorożyńska, Monika Majewska-Szczepanik, Katarzyna Marcińska, Marian Szczepanik
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28289221/gentamicin-b1-is-a-minor-gentamicin-component-with-major-nonsense-mutation-suppression-activity
#7
Alireza Baradaran-Heravi, Jürgen Niesser, Aruna D Balgi, Kunho Choi, Carla Zimmerman, Andrew P South, Hilary J Anderson, Natalie C Strynadka, Marcel B Bally, Michel Roberge
Nonsense mutations underlie about 10% of rare genetic disease cases. They introduce a premature termination codon (PTC) and prevent the formation of full-length protein. Pharmaceutical gentamicin, a mixture of several related aminoglycosides, is a frequently used antibiotic in humans that can induce PTC readthrough and suppress nonsense mutations at high concentrations. However, testing of gentamicin in clinical trials has shown that safe doses of this drug produce weak and variable readthrough activity that is insufficient for use as therapy...
March 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28286109/bullous-pemphigoid
#8
REVIEW
Işın Sinem Bağcı, Orsolya N Horváth, Thomas Ruzicka, Miklós Sárdy
Bullous pemphigoid (BP) is the most common autoimmune bullous disorder which is characterized by autoantibodies against hemidesmosomal proteins of the skin and mucous membranes. Collagen XVII and dystonin-e have been identified as target antigens. BP affects mostly the elderly. The incidence of the disease is increasing gradually and is associated with high morbidity and mortality. Clinically, BP is characterized by an intensely pruritic eruption with widespread bullous lesions. The clinical diagnosis can be challenging in the setting of atypical presentations...
May 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28247738/-bacterial-prostatitis-and-prostatic-fibrosis-modern-view-on-the-treatment-and-prophylaxis
#9
A V Zaitsev, D Yu Pushkar, L A Khodyreva, A A Dudareva
Treatments of chronic bacterial prostatitis (CP) remain difficult problem. Bacterial prostatitis is a disease entity diagnosed clinically and by evidence of inflammation and infection localized to the prostate. Risk factors for UTI in men include urological interventions, such as transrectal prostate biopsy. Ensuing infections after prostate biopsy, such as UTI and bacterial prostatitis, are increasing due to increasing rates of fluoroquinolone resistance. The increasing global antibiotic resistance also significantly affects management of UTI in men, and therefore calls for alternative strategies...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28193670/subinhibitory-concentrations-of-ciprofloxacin-enhance-antimicrobial-resistance-and-pathogenicity-of-enterococcus-faecium
#10
Clara Sinel, Margherita Cacaci, Pierrick Meignen, François Guérin, Bryan W Davies, Maurizio Sanguinetti, Jean-Christophe Giard, Vincent Cattoir
Enterococcus faecium has emerged as a major opportunistic pathogen for 2 decades with the spread of hospital-adapted multidrug-resistant clones. As members of the intestinal microbiota, they are subjected to numerous bacterial stresses, including antibiotics at subinhibitory concentrations (SICs). Since fluoroquinolones are extensively prescribed, SICs are very likely to occur in vivo, with potential effects on bacterial metabolism with subsequent modulation of opportunistic traits. The aim of this study was to evaluate globally the impact of SICs of ciprofloxacin on antimicrobial resistance and pathogenicity of E...
May 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28151005/allograft-heart-valves-current-aspects-and-future-applications
#11
REVIEW
Milan Lisy, Guenay Kalender, Katja Schenke-Layland, Kelvin G M Brockbank, Anna Biermann, Ulrich Alfred Stock
Human heart valve allografts continue to represent almost perfect substitutes for heart valves. They have optimal hemodynamic characteristics and are highly resistant to infections. The first clinical use of allograft heart valves was as homovitals being transplanted after antibiotic incubation without any preservation. Since 1968, relatively standardized frozen cryopreservation (SFC) has been employed, including storage in vapor-phase liquid nitrogen. Disadvantages, particularly in pediatric patients, are limited availability due to organ scarcity, inability to grow, degeneration, immune response, and long-term failure...
April 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28132822/the-release-kinetics-antimicrobial-activity-and-cytocompatibility-of-differently-prepared-collagen-hydroxyapatite-vancomycin-layers-microstructure-vs-nanostructure
#12
Tomáš Suchý, Monika Šupová, Eva Klapková, Václava Adamková, Jan Závora, Margit Žaloudková, Šárka Rýglová, Rastislav Ballay, František Denk, Marek Pokorný, Pavla Sauerová, Marie Hubálek Kalbáčová, Lukáš Horný, Jan Veselý, Tereza Voňavková, Richard Průša
The aim of this study was to develop an osteo-inductive resorbable layer allowing the controlled elution of antibiotics to be used as a bone/implant bioactive interface particularly in the case of prosthetic joint infections, or as a preventative procedure with respect to primary joint replacement at a potentially infected site. An evaluation was performed of the vancomycin release kinetics, antimicrobial efficiency and cytocompatibility of collagen/hydroxyapatite layers containing vancomycin prepared employing different hydroxyapatite concentrations...
March 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28129584/bone-natural-autofluorescence-and-confocal-laser-scanning-microscopy-preliminary-results-of-a-novel-useful-tool-to-distinguish-between-forensic-and-ancient-human-skeletal-remains
#13
Luigi Capasso, Ruggero D'Anastasio, Simone Guarnieri, Joan Viciano, Maria Mariggiò
The fast, high-throughput distinction between palaeoanthropological/archaeological remains and recent forensic/clinical bone samples is of vital importance in the field of medico-legal science. In this paper, a novel dating method was developed using the autofluorescence of human bones and the confocal laser scanning microscope as the means to distinguish between archaeological and forensic anthropological skeletal findings. Human bones exhibit fluorescence, typically induced by natural antibiotics that are absorbed by collagen, and provide secondary, exogenous fluorophores...
January 22, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28119114/evaluation-of-platelet-rich-plasma-gel-potential-in-acceleration-of-wound-healing-duration-in-patients-underwent-pilonidal-sinus-surgery-a-randomized-controlled-parallel-clinical-trial
#14
Saeed Mohammadi, Shirzad Nasiri, Mohammad Hossein Mohammadi, Ashraf Malek Mohammadi, Mohsen Nikbakht, Mahdi Zahed Panah, Hiva Safar, Shayan Mostafaei, Amir Hossein Norooznezhad, Ahmad Reza Soroosh, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
OBJECTIVES: One of the most important surgical issues applied in the treatment of pilonidal sinus disease is wound healing. The aim of this study was to investigate the possible effect of platelet-rich plasma (PRP) gel on accelerating wound healing in these patients. METHODS: In this randomized, controlled, parallel group clinical trial, 110 patients were randomly allocated into two parallel groups with the same size (controls and treatment arm) after meeting inclusion and exclusion criteria...
April 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28068758/strontium-doped-amorphous-calcium-phosphate-porous-microspheres-synthesized-through-a-microwave-hydrothermal-method-using-fructose-1-6-bisphosphate-as-an-organic-phosphorus-source-application-in-drug-delivery-and-enhanced-bone-regeneration
#15
Weilin Yu, Tuan-Wei Sun, Chao Qi, Zhenyu Ding, Huakun Zhao, Feng Chen, Daoyun Chen, Ying-Jie Zhu, Zhongmin Shi, Yaohua He
Nanostructured calcium phosphate porous microspheres are of great potential in drug delivery and bone regeneration due to their large specific surface area, biocompatibility, and similarity to inorganic component of osseous tissue. In this work, strontium (Sr)-doped amorphous calcium phosphate porous microspheres (SrAPMs) were synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate trisodium salt as the source of phosphate ions. The SrAPMs showed a mesoporous structure and a relatively high specific area...
February 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28068493/bmp1-and-tll1-are-required-for-maintaining-periodontal-homeostasis
#16
J Wang, D Massoudi, Y Ren, A M Muir, S E Harris, D S Greenspan, J Q Feng
Mutations in bone morphogenetic protein 1 (BMP1) in humans or deletion of BMP1 and related protease tolloid like 1 (TLL1) in mice lead to osteogenesis imperfecta (OI). Here, we show progressive periodontal defects in mice in which both BMP1 and TLL1 have been conditionally ablated, including malformed periodontal ligament (PDL) (recently shown to play key roles in normal alveolar bone formation), significant loss in alveolar bone mass ( P < 0.01), and a sharp reduction in cellular cementum. Molecular mechanism studies revealed a dramatic increase in the uncleaved precursor of type I collagen (procollagen I) and a reduction in dentin matrix protein 1 (DMP1), which is partially responsible for defects in extracellular matrix (ECM) formation and mineralization...
May 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28017866/collagen-tethering-of-synthetic-human-antimicrobial-peptides-cathelicidin-ll37-and-its-effects-on-antimicrobial-activity-and-cytotoxicity
#17
Lindsay D Lozeau, Jonian Grosha, Denis Kole, Fioleda Prifti, Tanja Dominko, Terri A Camesano, Marsha W Rolle
Wound infections, particularly of chronic wounds, pose a substantial challenge for designing antimicrobial dressings that are both effective against pathogens, and do not interfere with wound healing. Due to their broad-spectrum antimicrobial and immunomodulatory activities, naturally-occurring antimicrobial peptides (AMPs) are promising alternative treatments. However, their cytotoxicity at high concentrations and poor stability hinders their clinical use. To mitigate these undesirable properties, we investigated the effects of tethering human AMP cathelicidin LL37 to collagen, one of the main extracellular matrix proteins in wound sites, secreted by fibroblasts, and in commercially-available wound dressings...
April 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/27938770/successful-healing-of-tracheal-radionecrosis-role-of-hyperbaric-oxygen-therapy
#18
Miguel Ariza-Prota, Arturo Morales, Jose Grajeda, Rosa López-Lisbona, Noelia Cubero, Jordi Dorca, Antoni Rosell
Hyperbaric oxygen therapy, the administration of 100% oxygen at pressures > 1 atm, is believed to promote wound healing by increasing angiogenesis and collagen synthesis. To our knowledge, this treatment modality has never been described in patients with tracheal radionecrosis. Here, we report the case of a 55-year-old man diagnosed with stage IIIB lung adenocarcinoma who was treated with chemotherapy and concomitant external intensity-modulated radiotherapy involving the left lung and mediastinum. Nine months later, he presented with neck pain, cough with mucopurulent sputum, and fever...
December 2016: Chest
https://www.readbyqxmd.com/read/27913240/activity-of-vancomycin-release-from-bioinspired-coatings-of-hydroxyapatite-or-tio2-nanotubes
#19
Daniela Ionita, Daniela Bajenaru-Georgescu, Georgeta Totea, Anca Mazare, Patrik Schmuki, Ioana Demetrescu
Herein we investigate the efficiency of various biomimetic coatings for localized drug delivery, using vancomycin as key therapeutic drug, which is a widely used antibiotic for the treatment of strong infections caused by positive Gram bacteria. We evaluate classical hydroxyapatite and biomimetic hydroxyapatite-collagen coatings obtained by electrochemical deposition as well as TiO2 nanotubes arrays obtained by electrochemical anodization. Surface morphology, compositional and structural data confirm the incorporation of vancomycin into the layers and drug release profiles for vancomycin evaluate their release ability...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27890562/tailor-made-fibroblast-specific-and-antibiotic-free-interleukin-12-plasmid-for-gene-electrotransfer-mediated-cancer-immunotherapy
#20
Urska Kamensek, Natasa Tesic, Gregor Sersa, Spela Kos, Maja Cemazar
Electrotransfer mediated delivery of interleukin-12 (IL-12) gene, encoded on a plasmid vector, has already been demonstrated to have a potent antitumor efficacy and great potential for clinical application. In the present study, our aim was to construct an optimized IL-12-encoding plasmid that is safe from the regulatory point of view. In light of previous studies demonstrating that IL-12 should be released in a tumor localized manner for optimal efficacy, the strong ubiquitous promoter was replaced with a weak endogenous promoter of the collagen 2 gene, which is specific for fibroblasts...
November 24, 2016: Plasmid
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