Zhuqing Wan, Xiaoqiang Bai, Xin Wang, Xiaodong Guo, Xu Wang, Mo Zhai, Yang Fu, Yunsong Liu, Ping Zhang, Xiao Zhang, Ruili Yang, Yan Liu, Longwei Lv, Yongsheng Zhou
Activating autologous stem cells after the implantation of biomaterials is an important process to initiate bone regeneration. Although several studies have demonstrated the mechanism of biomaterial-mediated bone regeneration, a comprehensive single-cell level transcriptomic map revealing the influence of biomaterials on regulating the temporal and spatial expression patterns of mesenchymal stem cells (MSCs) is still lacking. Herein, the osteoimmune microenvironment is depicted around the classical collagen/nanohydroxyapatite-based bone repair materials via combining analysis of single-cell RNA sequencing and spatial transcriptomics...
April 8, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)