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https://www.readbyqxmd.com/read/28644556/sinus-augmentation-using-a-mini-pig-model-effect-of-ceramic-and-allogeneic-bone-biomaterials
#1
Cristiano Susin, Tiago Fiorini, Jaebum Lee, Rubens Moreno de Freitas, Hsien-Chung Chiu, Hari S Prasad, Amanda N Buxton, Ulf Me Wikesjö
BACKGROUND: Present clinical practice broadly relies on off-the-shelf allogeneic, xenogeneic or synthetic bone biomaterials in support of sinus augmentation. Also, recombinant human bone morphogenetic protein-2 in an absorbable collagen sponge carrier (rhBMP-2/ACS) has been shown to support clinically relevant bone formation when used to augment the maxillary sinus. OBJECTIVES: To evaluate local bone formation/dental implant osseointegration following implantation of two particulate bone biomaterials using the mini-pig sinus augmentation model...
June 23, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28643442/the-effect-of-collagen-coating-on-titanium-with-nanotopography-on-in-vitro-osteogenesis
#2
Daniel G Costa, Emanuela P Ferraz, Rodrigo P F Abuna, Paulo T de Oliveira, Marco Morra, Marcio M Beloti, Adalberto L Rosa
Several studies have shown the positive effects of Ti either with nanotopography or coated with collagen on osteoblast differentiation. Thus, we hypothesized that the association of nanotopography with collagen may increase the in vitro osteogenesis on Ti surface. Ti discs with nanotopography with or without collagen coating were characterized by scanning electron microscopy and atomic force microscopy. Rat calvaria-derived osteoblastic cells were cultured on both Ti surfaces for up to 14 days and the following parameters were evaluated: cell proliferation, alkaline phosphatase (ALP) activity, extracellular matrix mineralization, protein expression of bone sialoprotein (BSP) and osteopontin (OPN), and gene expression of collagen type 1a (Coll1a), runt related transcription factor 2 (Runx2), osterix (OSX), osteocalcin (OC), Ki67, Survivin and Bcl2 associated X protein (BAX)...
June 23, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28634845/histomorphometric-and-immunohistochemical-evaluation-of-collagen-containing-xenogeneic-bone-blocks-used-for-lateral-bone-augmentation-in-staged-implant-placement
#3
Alberto Ortiz-Vigón, Sergio Martinez-Villa, Iñaki Suarez, Fabio Vignoletti, Mariano Sanz
BACKGROUND: The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures. METHODS: In 15 patients with severe horizontal alveolar ridge resorption, lateral augmentation procedures were performed using CCXBB as bone replacement grafts. Twenty-six weeks postoperatively, a re-entry procedure was performed to evaluate the bone width for adequate implant placement and two histological specimens were retrieved from each patient, one being processed for ground sectioning and the other for decalcified paraffin-included sections...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28633987/a-paradigm-shift-for-bone-quality-in-dentistry-a-literature-review
#4
REVIEW
Shinichiro Kuroshima, Masaru Kaku, Takuya Ishimoto, Muneteru Sasaki, Takayoshi Nakano, Takashi Sawase
PURPOSE: The aim of this study was to present the current concept of bone quality based on the proposal by the National Institutes of Health (NIH) and some of the cellular and molecular factors that affect bone quality. STUDY SELECTION: This is a literature review which focuses on collagen, biological apatite (BAp), and bone cells such as osteoblasts and osteocytes. RESULTS: In dentistry, the term "bone quality" has long been considered to be synonymous with bone mineral density (BMD) based on radiographic and sensible evaluations...
June 17, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28633197/influence-of-electron-beam-irradiation-doses-on-bone-regeneration-by-octacalcium-phosphate-collagen-composites
#5
Fumihiko Kajii, Atsushi Iwai, Hidenori Tanaka, Keiko Matsui, Tadashi Kawai, Shinji Kamakura
An octacalcium phosphate and collagen composite (OCP/Col) achieved efficient bone regeneration with excellent resorbability. After the confirmation of its safety and efficacy in preclinical animal studies, the present study investigated the influence of electron beam irradiation doses on bone regeneration by OCP/Col in order to secure its commercialization. OCP/Col was prepared as previously described, and the packed OCP/Col was sterilized using different doses of electron beam irradiation. A standardized defect, 9 mm in diameter, was made in the rat calvarium...
June 20, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28628484/battling-bacterial-infection-with-hexamethylene-diisocyanate-cross-linked-and-cefaclor-loaded-collagen-scaffolds
#6
E K Tsekoura, A L Helling, J G Wall, Y Bayon, D I Zeugolis
Implant infections remain a major healthcare problem due to the prolonged hospitalisation period required to disrupt and treat bacterial biofilm formation, and the need for additional surgery to remove/replace the infected implant, which if not removed in a timely manner may lead to sepsis. Although localised drug administration, via an implanted scaffold, has shown promise in a clinical setting, the ideal scaffold cross-linking (to initially withstand the aggressive infection environment) and drug (to be effective against infection) have yet to be identified...
June 19, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28626970/surgical-treatment-of-peri-implantitis-intrabony-lesions-by-means-of-deproteinized-bovine-bone-mineral-with-10-collagen-7-year-results
#7
Mario Roccuzzo, Dario Pittoni, Andrea Roccuzzo, Lorena Charrier, Paola Dalmasso
OBJECTIVES: The aim of this study was to evaluate the long-term results of the surgical treatment of single peri-implantitis intrabony defects, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC). MATERIAL AND METHODS: The original population consisted of 26 patients with one crater-like defect, around either sandblasted and acid-etched (SLA) or titanium plasma-sprayed (TPS) dental implants, with a probing depth (PD) ≥6 mm and no implant mobility (Roccuzzo et al...
June 18, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28621514/in-vitro-and-in-vivo-analysis-of-mineralized-collagen-based-sponges-prepared-by-a-plasma-and-precursor-assisted-biomimetic-process
#8
A Joseph Nathanael, Ayako Oyane, Maki Nakamura, Ikuko Sakamaki, Erika Nishida, Yukimi Kanemoto, Hirofumi Miyaji
Three-dimensional (3D) porous scaffolds for supporting cell adhesion and growth play a vital role in tissue engineering applications. In the present study, three different collagen-based 3D sponges were functionalized by apatite coating. The sponges were coated with apatite on their outer and inner surfaces while retaining their interconnecting pores. To achieve this, we employed a vacuum degassing system in our plasma- and precursor-assisted biomimetic process, using a supersaturated calcium phosphate solution...
June 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28620706/complete-corneal-ring-myoring-implantation-versus-myoring-implantation-combined-with-corneal-collagen-crosslinking-for-keratoconus-3-year-follow-up
#9
Guzel Bikbova, Gyulli Kazakbaeva, Mukharram Bikbov, Emin Usubov
PURPOSE: To estimate the effectiveness of complete corneal ring (MyoRing) implantation compared with MyoRing implantation combined with corneal collagen crosslinking (CXL) for keratoconus treatment for 36 months follow-up. DESIGN: Retrospective cohort study. MATERIALS AND METHODS: MyoRing implantation was performed in a series of 78 patients (80 eyes) with keratoconus II-III Amsler classification, of these 39 eyes had MyoRing implantation combined with CXL...
June 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28619543/circumferential-three-dimensional-printed-tracheal-grafts-research-model-feasibility-and-early-results
#10
Faiz Y Bhora, Erik E Lewis, Sadiq S Rehmani, Adil Ayub, Wissam Raad, Adnan M Al-Ayoubi, Robert S Lebovics
BACKGROUND: Methods for tracheal graft research have presented persistent challenges to investigators, and three-dimensional (3D)-printed biosynthetic grafts offer one potential development platform. We aimed to develop an efficient research platform for customizable circumferential 3D-printed tracheal grafts and evaluate feasibility and early structural integrity with a large-animal model. METHODS: Virtual 3D models of porcine subject tracheas were generated using preoperative computed tomography scans...
June 13, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28618433/crestal-sinus-augmentation-with-recombinant-human-bone-morphogenetic-protein-2-clinical-and-radiographic-outcomes-of-2-year-pilot-trial
#11
Ulrike Kuchler, Claudia M Rudelstorfer, Barbara Barth, Gabor Tepper, Dominika Lidinsky, Patrick Heimel, Georg Watzek, Reinhard Gruber
PURPOSE: Recombinant human bone morphogenetic protein 2 (rhBMP-2) together with an absorbable collagen carrier (ACS) was approved for augmentation of the maxillary sinus prior to implant placement. The original registration trial was based on a lateral window approach. Clinical outcomes of crestal sinus augmentation with rhBMP-2 have not been reported so far. MATERIALS AND METHODS: An uncontrolled pilot trial in which seven patients with a residual maxillary height below 5 mm were enrolled to receive crestal sinus augmentation with rhBMP-2/ACS was conducted...
June 14, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28617531/controlled-release-mitomycin-c-polylactic-acid-film-prevents-epidural-scar-hyperplasia-after-laminectomy-by-inducing-fibroblast-autophagy-and-regulating-the-expression-of-mirnas
#12
B-B Wang, H Xie, T Wu, N Xie, J Wu, Y Gu, F Tang, J Liu
OBJECTIVE: To design a new controlled-release MMC-PLA film and explore whether and how this film could prevent epidural scar hyperplasia and adhesion in a post-laminectomy rat model. MATERIALS AND METHODS: All procedures were performed under the approval and supervision of the Institutional Animal Care and Use Committee (IACUC) of Nanjing Medical University. A total of 120 Sprague-Dawley (SD) rats were randomly placed into four groups after laminectomy (each group=30 rats)...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28616703/preparation-of-a-biphase-composite-scaffold-and-its-application-in-tissue-engineering-for-femoral-osteochondral-defects-in-rabbits
#13
Shi-Qiang Ruan, Ling Yan, Jiang Deng, Wen-Liang Huang, Dian-Ming Jiang
PURPOSE: Three-dimensional bioactive scaffolds are useful tools for stem cell implant in tissue-engineering. For chondral and subchondral repair, the chondroinductive and osteoinductive property of a scaffold is a major challenge. The scaffolds that aim to osteogenic differentiation have been well studied. However, cartilage cells can hardly be induced for osteogenesis, and monophase scaffolds cannot ideally repair both cartilage and subchondral defects at the same time. METHODS: We developed a novel biphase composite scaffold and observe its application osteochondral defects...
June 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28615491/enhanced-osteointegration-of-poly-methylmethacrylate-bone-cements-by-incorporating-strontium-containing-borate-bioactive-glass
#14
Xu Cui, Chengcheng Huang, Meng Zhang, Changshun Ruan, Songlin Peng, Li Li, Wenlong Liu, Ting Wang, Bing Li, Wenhai Huang, Mohamed N Rahaman, William W Lu, Haobo Pan
Although poly(methylmethacrylate) (PMMA) cements are widely used in orthopaedics, they have numerous drawbacks. This study aimed to improve their bioactivity and osseointegration by incorporating strontium-containing borate bioactive glass (SrBG) as the reinforcement phase and bioactive filler of PMMA cement. The prepared SrBG/PMMA composite cements showed significantly decreased polymerization temperature when compared with PMMA and retained properties of appropriate setting time and high mechanical strength...
June 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28613059/-experimental-study-of-transforming-growth-factor-%C3%AE-3-combined-with-dental-pulp-stem-cells-in-promoting-the-implant-s-osseointegration
#15
T Wang, Huojia Muhetaer, J Li
Objective: To investigate the effect of transforming growth factor-β3 (TGF-β3) and dental pulp stem cells (DPSC) in promoting the implant's osteointegration. Methods: Thirty-three New Zealand white rabbits were randomly divided into phosphate buffer saline (PBS) group, DPSC group and TGF-β3 + DPSC group (12 rabbits/group). Two teeth from the rabbits's mandibular incisors or molars were pulled out randomly, then implant were placed in the tooth extraction site immediately. In PBS group, the implant area was filled with Bio-Oss powder 0...
June 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28611369/enhanced-chondrogenesis-of-bone-marrow-derived-stem-cells-by-using-a-combinatory-cell-therapy-strategy-with-bmp-2-tgf-%C3%AE-1-hypoxia-and-col1a1-htra1-sirnas
#16
Florence Legendre, David Ollitrault, Tangni Gomez-Leduc, Mouloud Bouyoucef, Magalie Hervieu, Nicolas Gruchy, Frédéric Mallein-Gerin, Sylvain Leclercq, Magali Demoor, Philippe Galéra
Mesenchymal stem cells (MSCs) hold promise for cartilage engineering. Here, we aimed to determine the best culture conditions to induce chondrogenesis of MSCs isolated from bone marrow (BM) of aged osteoarthritis (OA) patients. We showed that these BM-MSCs proliferate slowly, are not uniformly positive for stem cell markers, and maintain their multilineage potential throughout multiple passages. The chondrogenic lineage of BM-MSCs was induced in collagen scaffolds, under normoxia or hypoxia, by BMP-2 and/or TGF-β1...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28610487/establishment-of-novel-meniscal-scaffold-structures-using-polyglycolic-and-poly-l-lactic-acids
#17
Tomohiko Murakami, Shuhei Otsuki, Kosuke Nakagawa, Yoshinori Okamoto, Tae Inoue, Yuki Sakamoto, Hideki Sato, Masashi Neo
The purpose of this study was to evaluate various types of meniscus scaffolds that mimic the meniscus structure, and to establish a novel cell-free meniscus scaffold with polyglycolic acid or poly-l-lactic acid. Four types of scaffolds were implanted into Japanese white rabbits: poly-l-lactic acid sponge poly-l-lactic acid, PGA-coated PLLA sponge, PGA lamination, and film-coated PGA lamination. Samples were harvested at 8 and 12 weeks after implantation, and a compression stress test was performed. The meniscus size and Ishida scores were evaluated for regenerated tissue...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28610485/effects-of-the-bilayer-nano-hydroxyapatite-mineralized-collagen-guided-bone-regeneration-membrane-on-site-preservation-in-dogs
#18
Yi Sun, Chengyue Wang, Qixin Chen, Hai Liu, Chao Deng, Peixue Ling, Fu-Zhai Cui
This study was aimed at assessing the effects of the porous mineralized collagen plug with or without the bilayer mineralized collagen-guided bone regeneration membrane on alveolar ridge preservation in dogs. The third premolars in the bilateral maxilla of mongrel dogs ( N = 12) were extracted. Twenty-four alveolar sockets were thus randomly divided into three groups: membrane + collagen plug (MP, n = 8), nonmembrane + collagen plug (NP, n = 8) and blank group without any implantation (BG, n = 8)...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28610471/mechanically-loading-cell-hydrogel-constructs-with-low-intensity-pulsed-ultrasound-for-bone-repair
#19
James A Veronick, Fayekah Assanah, Nicole J Piscopo, Yasemin Kutes, Varun Vyas, Bryan D Huey, Yusuf Khan
Low-intensity pulsed ultrasound (LIPUS) has been shown to be effective for orthopaedic fracture repair and non-union defects but the specific mechanism behind its efficacy is still unknown. Previously we have shown a measurable acoustic radiation force at LIPUS intensities traditionally used for clinical treatment and have applied this force to osteoblastic cells encapsulated in type I collagen hydrogels. Our goal here is to provide insight and inform the appropriate design of a cell therapy approach to bone repair in which osteoblasts are embedded in collagen hydrogels, implanted into a bony defect, and then transdermally stimulated using LIPUS-derived acoustic radiation force to enhance bone formation at the earliest time points after bone defect repair...
June 13, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28608839/microgroove-and-collagen-poly-%C3%AE%C2%B5-caprolactone-nanofiber-mesh-coating-improves-the-mechanical-stability-and-osseointegration-of-titanium-implants
#20
Morshed Khandaker, Shahram Riahinezhad, Wendy R Williams, Roman Wolf
The effect of depositing a collagen (CG)-poly-ε-caprolactone (PCL) nanofiber mesh (NFM) at the microgrooves of titanium (Ti) on the mechanical stability and osseointegration of the implant with bone was investigated using a rabbit model. Three groups of Ti samples were produced: control Ti samples where there were no microgrooves or CG-PCL NFM, groove Ti samples where microgrooves were machined on the circumference of Ti, and groove-NFM Ti samples where CG-PCL NFM was deposited on the machined microgrooves...
June 13, 2017: Nanomaterials
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