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https://www.readbyqxmd.com/read/29351870/de-novo-generation-in-an-in-vivo-rat-model-and-biomechanical-characterization-of-autologous-transplants-for-ligament-and-tendon-reconstruction
#1
Marc Soubeyrand, Elisabeth Laemmel, Nathalie Maurel, Amadou Diop, Thierry Lazure, Jacques Duranteau, Eric Vicaut
BACKGROUND: Surgical reconstruction of ligaments and tendons is frequently required in clinical practice. The commonly used autografts, allografts, or synthetic transplants present limitations in terms of availability, biocompatibility, cost, and mechanical properties that tissue bioengineering aims to overcome. It classically combines an exogenous extracellular matrix with cells, but this approach remains complex and expensive. Using a rat model, we tested a new bioengineering strategy for the in vivo and de novo generation of autologous grafts without the addition of extracellular matrix or cells, and analyzed their biomechanical and structural properties...
December 14, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29348423/a-tissue-mimetic-nano-fibrillar-hybrid-injectable-hydrogel-for-potential-soft-tissue-engineering-applications
#2
Neda Latifi, Meisam Asgari, Hojatollah Vali, Luc Mongeau
While collagen type I (Col-I) is commonly used as a structural component of biomaterials, collagen type III (Col-III), another fibril forming collagen ubiquitous in many soft tissues, has not previously been used. In the present study, the novel concept of an injectable hydrogel with semi-interpenetrating polymeric networks of heterotypic collagen fibrils, with tissue-specific Col-III to Col-I ratios, in a glycol-chitosan matrix was investigated. Col-III was introduced as a component of the novel hydrogel, inspired by its co-presence with Col-I in many soft tissues, its influence on the Col-I fibrillogenesis in terms of diameter and mechanics, and its established role in regulating scar formation...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29341933/the-effects-of-platelet-lysate-patches-on-the-activity-of-tendon-derived-cells
#3
Raquel Costa-Almeida, Albina R Franco, Tamagno Pesqueira, Mariana B Oliveira, Pedro S Babo, Isabel B Leonor, João F Mano, Rui L Reis, Manuela E Gomes
Platelet-derived biomaterials are widely explored as cost-effective sources of therapeutic factors, holding a strong potential for endogenous regenerative medicine. Particularly for tendon repair, treatment approaches that shift the injury environment are explored to accelerate tendon regeneration. Herein, genipin-crosslinked platelet lysate (PL) patches are proposed for the delivery of human-derived therapeutic factors in patch augmentation strategies aiming at tendon repair. Developed PL patches exhibited a controlled release profile of PL proteins, including bFGF and PDGF-BB...
January 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29340931/vascutrainer-a-mobile-and-disposable-bioreactor-system-for-the-conditioning-of-tissue-engineered-vascular-grafts
#4
Frederic Wolf, Diana M Rojas González, Ulrich Steinseifer, Markus Obdenbusch, Werner Herfs, Christian Brecher, Stefan Jockenhoevel, Petra Mela, Thomas Schmitz-Rode
In vitro tissue engineering of vascular grafts requires dynamic conditioning in a bioreactor system for in vitro tissue maturation and remodeling to receive a mechanically adequate and hemocompatible implant. The goal of the current work was to develop a bioreactor system for the conditioning of vascular grafts which is (i) able to create a wide range of flow, pressure and frequency conditions, including physiological ones; (ii) compact and easy to assemble; (iii) transportable; (iv) disposable. The system is driven by a small centrifugal pump controlled via a custom-made control unit, which can also be operated on batteries to allow for autonomous transportation...
January 16, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29340746/similar-clinical-outcomes-following-collagen-or-polyurethane-meniscal-scaffold-implantation-a-systematic-review
#5
REVIEW
Darby A Houck, Matthew J Kraeutler, John W Belk, Eric C McCarty, Jonathan T Bravman
PURPOSE: The purpose of this systematic review is to evaluate the current literature in an effort to assess specific clinical outcomes following meniscal scaffold implantation using the two available scaffolds: Collagen Meniscal Implant (CMI) and the Actifit polyurethane meniscal scaffold. METHODS: A systematic review was performed by searching PubMed, Embase, and Cochrane Library to find studies evaluating clinical outcomes of patients undergoing meniscal scaffold implantation...
January 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29340634/efficient-decellularization-for-bovine-pericardium-with-extracellular-matrix-preservation-and-good-biocompatibility
#6
Ning Li, Yang Li, Dejun Gong, Cuiping Xia, Xiaohong Liu, Zhiyun Xu
OBJECTIVES: In this study, we sought to explore an efficient decellularization protocol for bovine pericardia with better extracellular matrix preservation and good biocompatibility. METHODS: Bovine pericardia were decellularized by sodium dodecyl sulphate (SDS), SDS + sodium deoxycholate (SD), Triton X-100 (TX), TX + SD (TS), freeze-thaw cycles + SDS + SD (FSS) and freeze-thaw cycles + TX + SD (FTS), respectively. Untreated pericardia were used as native control...
January 10, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29338716/donor-age-affects-proteome-composition-of-tenocyte-derived-engineered-tendon
#7
Agnieszka J Turlo, Yalda Ashraf Kharaz, Peter D Clegg, James Anderson, Mandy J Peffers
BACKGROUND: The concept of tissue engineering is to deliver to the injury site biological scaffolds carrying functional cells that will enhance healing response. The preferred cell source is autologous in order to reduce immune response in the treated individual. However, in elderly patients age-related changes in synthetic activity of the implanted cells and subsequent alterations in tissue protein content may affect therapeutic outcomes. In this study we investigated the effect of donor age on proteome composition of tenocyte-derived tendon tissue-engineered constructs...
January 16, 2018: BMC Biotechnology
https://www.readbyqxmd.com/read/29333323/alveolar-ridge-preservation-with-an-open-healing-approach-using-single-layer-or-double-layer-coverage-with-collagen-membranes
#8
Ho-Keun Choi, Hag-Yeon Cho, Sung-Jo Lee, In-Woo Cho, Hyun-Seung Shin, Ki-Tae Koo, Hyun-Chang Lim, Jung-Chul Park
Purpose: The aim of this prospective pilot study was to compare alveolar ridge preservation (ARP) procedures with open-healing approach using a single-layer and a double-layer coverage with collagen membranes using radiographic and clinical analyses. Methods: Eleven molars from 9 healthy patients requiring extraction of the maxillary or mandibular posterior teeth were included and allocated into 2 groups. After tooth extraction, deproteinized bovine bone mineral mixed with 10% collagen was grafted into the socket and covered either with a double-layer of resorbable non-cross-linked collagen membranes (DL group, n=6) or with a single-layer (SL group, n=5)...
December 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29333322/a-randomized-controlled-clinical-study-of-periodontal-tissue-regeneration-using-an-extracellular-matrix-based-resorbable-membrane-in-combination-with-a-collagenated-bovine-bone-graft-in-intrabony-defects
#9
Sulhee Kim, Hyeyoon Chang, Jin Wook Hwang, Sungtae Kim, Ki-Tae Koo, Tae-Il Kim, Yang-Jo Seol, Yong-Moo Lee, Young Ku, Jong-Ho Lee, In-Chul Rhyu
Purpose: The purpose of this study was to investigate the feasibility of regenerative therapy with a collagenated bone graft and resorbable membrane in intrabony defects, and to evaluate the effects of the novel extracellular matrix (ECM)-based membrane clinically and radiologically. Methods: Periodontal tissue regeneration procedure was performed using an ECM-based resorbable membrane in combination with a collagenated bovine bone graft in intrabony defects around the teeth and implants...
December 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29331958/platelet-secretion-defects-and-acquired-von-willebrand-syndrome-in-patients-with-ventricular-assist-devices
#10
Ulrich Geisen, Kerstin Brehm, Georg Trummer, Michael Berchtold-Herz, Claudia Heilmann, Friedhelm Beyersdorf, Johannes Schelling, Axel Schlagenhauf, Barbara Zieger
BACKGROUND: The number of implanted ventricular assist devices (VADs) has increased significantly recently. Bleeding, the most frequent complication, cannot be solely attributed to anticoagulation therapy. Acquired von Willebrand syndrome (AVWS) caused by increased shear stress is frequent in VAD patients and can increase the bleeding risk. The HeartMate III (HM III) is a novel left VAD featuring potential improvements over the HeartMate II. METHODS AND RESULTS: In this study, we investigated the prevalence and onset of AVWS in 198 VAD patients...
January 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29331090/enhanced-chondrogenesis-of-mesenchymal-stem-cells-over-silk-fibroin-chitosan-chondroitin-sulfate-three-dimensional-scaffold-in-dynamic-culture-condition
#11
Parinita Agrawal, Krishna Pramanik, Varshini Vishwanath, Amit Biswas, Akalabya Bissoyi, Pradeep Kumar Patra
Chondroitin sulfate (Ch) is one of the main structural components of cartilage tissue, therefore, its presence in tissue engineered scaffold is expected to enhance cartilage regeneration. Previously, silk fibroin/chitosan (SF/CS) blend was proven to be a potential biomaterial for tissue development. In this study, the effect of Ch on physicochemical and biological properties of SF/CS blend was investigated and scaffolds with 0.8 wt% Ch was found to be favorable. The scaffolds possess pore size of 37-212 µm, contact angle 46...
January 13, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29330835/international-guidelines-for-groin-hernia-management
#12
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
January 12, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29327490/fetal-subcutaneous-cells-have-potential-for-autologous-tissue-engineering
#13
Åsa Ekblad, Magnus Westgren, Magdalena Fossum, Cecilia Götherström
BACKGROUND: Major congenital malformations affect up to 3% of newborns. Infants with prenatally diagnosed soft tissue defects should benefit from having autologous tissue readily available for surgical implantation in the perinatal period. In this study, we investigate fetal subcutaneous cells (fSC) as cellular source for tissue engineering. METHODS: Fetal subcutaneous biopsies were collected from elective terminations at gestational week 20-21. Cells were isolated, expanded and characterized in vitro...
January 11, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29327428/an-endochondral-ossification-approach-to-early-stage-bone-repair-use-of-tissue-engineered-hypertrophic-cartilage-constructs-as-primordial-templates-for-weight-bearing-bone-repair
#14
Amos Matsiko, Emmet M Thompson, Cai Lloyd-Griffith, Gráinne M Cunniffe, Tatiana Vinardell, John P Gleeson, Daniel J Kelly, Fergal J O'Brien
Mimicking endochondral ossification to engineer constructs offers a novel solution to overcoming the problems associated with poor vascularisation in bone repair. This can be achieved by harnessing the angiogenic potency of hypertrophic cartilage. In this study, we demonstrate that tissue-engineered hypertrophically-primed cartilage constructs can be developed from collagen-based scaffolds cultured with mesenchymal stem cells. These constructs were subsequently implanted into femoral defects in rats. It was evident that the constructs could support enhanced early-stage healing at 4 weeks of these weight-bearing femoral bone defects compared to untreated defects...
January 11, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29325832/the-pics-technique-a-novel-approach-for-residual-curvature-correction-during-penile-prosthesis-implantation-in-patients-with-severe-peyronie-s-disease-using-the-collagen-fleece-tachosil
#15
Georgios Hatzichristodoulou
BACKGROUND: Correction of residual curvature during inflatable penile prosthesis (IPP) implantation in patients with Peyronie's disease (PD) by plaque incision and grafting is a common approach. AIM: To present a novel technique for residual curvature correction during IPP implantation using collagen fleece (TachoSil, Baxter Healthcare Corp, Deerfield, IL, USA). METHODS: After the IPP (Titan Touch, Coloplast, Minneapolis, MN, USA) is placed, the implant is inflated maximally...
January 8, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29318405/the-efficacy-of-a-porcine-collagen-matrix-in-keratinized-tissue-augmentation-a-5-year-follow-up-study
#16
C Maiorana, L Pivetti, F Signorino, G B Grossi, A S Herford, M Beretta
BACKGROUND: When keratinized tissue width around dental implants is poorly represented, the clinician could resort to autogenous soft tissue grafting. Autogenous soft tissue grafting procedures are usually associated with a certain degree of morbidity. Collagen matrices could be used as an alternative to reduce morbidity and intra-operatory times. The aim of this study was to assess the efficacy of a xenogeneic collagen matrix as a substitute for soft tissue grafting around dental implants...
January 10, 2018: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/29316218/local-administration-of-nuclear-factor-of-activated-t-cells-nfat-c1-inhibitor-to-suppress-early-resorption-and-inflammation-induced-by-bone-morphogenetic-protein-2
#17
Ri Youn Kim, Yeju Seong, Tae Hyung Cho, Beomseok Lee, In Sook Kim, Soon Jung Hwang
Nuclear factor of activated T cells (NFAT)-c1 is known as a key regulator in osteoclast differentiation and immune response. This study is a follow-up to our previous study showing the anti-resorptive activity of VIVIT, a peptide type NFATc1 inhibitor, using absorbable collagen sponge (ACS). This study aimed to investigate the effective concentration range of local VIVIT that suppresses early excessive osteoclast activation and inflammation induced by high-dose recombinant human bone morphogenetic protein (rhBMP)-2 and concomitantly enhances bone healing in a rat critical-sized calvaria defect model...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29316182/lateral-bone-augmentation-in-narrow-posterior-mandibles-description-of-a-novel-approach-and-analysis-of-results
#18
Ilan Beitlitum, Alon Sebaoun, Carlos E Nemcovsky, Shimshon Slutzkey
BACKGROUND: Combination of particulate grafts and collagen membranes is widely used for augmentation of bony defects for implant placement. Fixation of the barrier membrane may avoid complications due to unfavorable mechanical properties and poor stability leading to collapse of the augmented area. PURPOSE: To evaluate a new simplified method for resorbable collagen membrane fixation in lateral bone augmentation procedures in narrow posterior mandibles. MATERIALS AND METHODS: This retrospective study analyzed 16 procedures performed in 15 patients who followed lateral ridge augmentation procedures before implant placement in the posterior mandible...
January 8, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29306747/heterocellular-3d-scaffolds-as-biomimetic-to-recapitulate-the-tumor-microenvironment-of-peritoneal-metastases-in%C3%A2-vitro-and-in%C3%A2-vivo
#19
Emiel De Jaeghere, Elly De Vlieghere, Jasper Van Hoorick, Sandra Van Vlierberghe, Glenn Wagemans, Leen Pieters, Elodie Melsens, Marleen Praet, Jo Van Dorpe, Matthieu N Boone, Rouba Ghobeira, Nathalie De Geyter, Marc Bracke, Christian Vanhove, Sara Neyt, Geert Berx, Bruno G De Geest, Peter Dubruel, Heidi Declercq, Wim Ceelen, Olivier De Wever
Peritoneal metastasis is a major cause of death and preclinical models are urgently needed to enhance therapeutic progress. This study reports on a hybrid hydrogel-polylactic acid (PLA) scaffold that mimics the architecture of peritoneal metastases at the qualitative, quantitative and spatial level. Porous PLA scaffolds with controllable pore size, geometry and surface properties are functionalized by type I collagen hydrogel. Co-seeding of cancer-associated fibroblasts (CAF) increases cancer cell adhesion, recovery and exponential growth by in situ heterocellular spheroid formation...
December 23, 2017: Biomaterials
https://www.readbyqxmd.com/read/29305336/circulating-osteogentic-precursor-cells-in-non-hereditary-heterotopic-ossification
#20
REVIEW
Kevin P Egan, Gustavo Duque, Mary Ann Keenan, Robert J Pignolo
Non-hereditary heterotopic ossification (NHHO) may occur after musculoskeletal trauma, central nervous system (CNS) injury, or surgery. We previously described circulating osteogenic precursor (COP) cells as a bone marrow-derived type 1 collagen+CD45+subpopulation of mononuclear adherent cells that are able of producing extraskeletal ossification in a murine in vivo implantation assay. In the current study, we performed a tissue analysis of COP cells in NHHO secondary to defined conditions, including traumatic brain injury, spinal cord injury, cerebrovascular accident, trauma without neurologic injury, and joint arthroplasty...
January 2, 2018: Bone
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