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https://www.readbyqxmd.com/read/29782973/enhanced-retinal-pigment-epithelium-rpe-regeneration-using-curcumin-alginate-hydrogels-in-vitro-evaluation
#1
Jong Ho Park, Eun Yeong Shin, Myeong Eun Shin, Min Joung Choi, Cristiano Carlomagno, Jeong Eun Song, Gilson Khang
The retinal pigment epithelium (RPE) plays a significant role in retaining structural integrity of eye. Factors such as reduction in cell regeneration due to aging and physical injury pose a major hurdle in RPE regeneration. In this study, we exploited the use of alginate (AGT) incorporated with Curcumin (CCI) forming a hydrogel based system CCI/AGT. The fabricated hydrogel could anchor RPE cell in it. In vitro cell analysis revealed that the CCI/AGT hydrogel shows good biocompatibility, enhanced cell growth ability and higher ECM formation compared to the pure AGT hydrogel...
May 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29782946/delivery-of-the-improved-bmp-2-advanced-plasmid-dna-within-a-gene-activated-scaffold-accelerates-mesenchymal-stem-cell-osteogenesis-and-critical-size-defect-repair
#2
Rosanne M Raftery, Irene Mencía-Castaño, Simon Sperger, Gang Chen, Brenton Cavanagh, Georg Feichtinger, Heinz Redl, Ara Hacobian, Fergal J O'Brien
Gene-activated scaffolds have been shown to induce controlled, sustained release of functional transgene both in vitro and in vivo. Bone morphogenetic proteins (BMPs) are potent mediators of osteogenesis however we found that the delivery of plasmid BMP-2 (pBMP-2) alone was not sufficient to enhance bone formation. Therefore, the aim of this study was to assess if the use of a series of modified BMP-2 plasmids could enhance the functionality of a pBMP-2 gene-activated scaffold and ultimately improve bone regeneration when implanted into a critical sized bone defect in vivo...
May 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29779644/development-of-a-novel-tissue-engineered-nitinol-frame-artificial-trachea-with-native-like-physical-characteristics
#3
Yasuto Sakaguchi, Toshihiko Sato, Yusuke Muranishi, Yojiro Yutaka, Teruya Komatsu, Koichi Omori, Tatsuo Nakamura, Hiroshi Date
BACKGROUND: Tracheal reconstruction is complicated by the short length to which a trachea can be resected. We previously developed a biocompatible polypropylene frame artificial trachea, but it lacked the strength and flexibility of the native trachea. In contrast, nitinol may provide these physical characteristics. We developed a novel nitinol frame artificial trachea and examined its biocompatibility and safety in canine models. METHODS: We constructed several nitinol frame prototypes and selected the frame that most closely reproduced the strength of the native canine trachea...
April 24, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29774080/microrna-193b-3p-regulates-chondrogenesis-and-chondrocyte-metabolism-by-targeting-hdac3
#4
Fangang Meng, Zhiwen Li, Zhiqi Zhang, Zibo Yang, Yan Kang, Xiaoyi Zhao, Dianbo Long, Shu Hu, Minghui Gu, Suiwen He, Peihui Wu, Zongkun Chang, Aishan He, Weiming Liao
Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-specific gene expression in human chondrocytes. The aim of this study was to determine whether microRNA-193b-3p (miR-193b-3p) regulates the expression of HDAC3 during chondrogenesis and chondrocyte metabolism. Methods: miR-193b-3p expression was assessed in a human mesenchymal stem cell (hMSC) model of chondrogenesis, in interleukin-1β (IL-1β)-treated primary human chondrocytes (PHCs), and in non-degraded and degraded cartilage...
2018: Theranostics
https://www.readbyqxmd.com/read/29770578/effect-of-silicon-doped-calcium-phosphate-bone-grafting-materials-on-bone-regeneration-and-osteogenic-marker-expression-after-implantation-in-the-ovine-scapula
#5
Christine Knabe, Doaa Adel-Khattab, Wolf-Dietrich Hübner, Fabian Peters, Tom Knauf, Barbara Peleska, Dirk Barnewitz, Antje Genzel, Roderik Kusserow, Florian Sterzik, Michael Stiller, Christian Müller-Mai
Compared to the currently clinically available bone grafting materials for alveolar ridge augmentation, there is a great demand for bioactive bone substitutes with higher resorbability, which enhance osteogenesis at the same time. This has prompted the development of a silicon-doped rapidly resorbable calcium alkali orthophosphate (Si-CAOP) and silicon-doped β-tricalcium phosphate (Si-TCP). This study evaluated the effect of these two particulate graft materials as compared to the currently clinically used β-TCP on bone formation and osteogenic marker expression after 2 weeks, 1, 3, 6, 12, and 18 months of implantation in critical size defects in the sheep scapula...
May 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29767434/regenerative-surgical-therapy-for-peri-implantitis-using-deproteinized-bovine-bone-mineral-with-10-collagen-enamel-matrix-derivative-and-doxycycline-a-prospective-3-year-cohort-study
#6
Faustino Mercado, Stephen Hamlet, Saso Ivanovski
OBJECTIVES: There is limited evidence regarding the long-term efficacy of regenerative treatment for peri-implantitis. The aim of this study was to evaluate a combination therapy of deproteinized bovine bone mineral with 10% collagen (DBBMC), enamel matrix derivative (EMD) and Doxycycline in the regeneration of bone defects associated with peri-implantitis. METHODS: Thirty patients diagnosed with peri-implantitis (BoP/suppuration, probing depth greater than 4 mm, minimum radiographic bone loss of 20%, at least 2 years in function) were enrolled in the study...
May 16, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29766758/anti-inflammatory-peptide-attenuates-edema-and-promotes-bmp-2-induced-bone-formation-in-spine-fusion
#7
Juliane D Glaeser, Khosrowdad Salehi, Linda Kanim, Dmitriy Sheyn, Zachary NaPier, Phillip Behrens, Leslie Garcia, Jason M Cuéllar, Hyun W Bae
Recombinant human bone morphogenic protein-2 (BMP-2) loaded absorbable collagen sponges (ACS) have been successfully used to enhance bone formation and to induce spinal fusion in humans. However, side effects, such as soft-tissue edema and inflammation, have been reported. NEMO binding domain peptide (NBD) inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a central regulator of immune response. In this study, we investigated NBD's potential to reduce BMP-2-induced soft-tissue inflammation without affecting BMP-2-mediated spinal fusion in rat...
May 16, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29766751/overcoming-challenges-in-engineering-large-scaffold-free-neocartilage-with-functional-properties
#8
Brian J Huang, Wendy E Brown, Thomas Keown, Jerry C Hu, Kyriacos A Athanasiou
Although numerous cartilage engineering methods have been described, few report generation of constructs greater than 4 cm2, which is the typical lesion size considered for cell-based therapies. Furthermore, current cell-based therapies only target focal lesions, while treatment of large non-isolated lesions remains an area of great demand. The objective of this study was to scale-up fabrication of self-assembled neocartilage from standard sizes of 0.2 cm2 to greater than 8 cm2. Passaged sheep articular chondrocytes were self-assembled into 5 mm or 25 mm dia...
May 16, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29766656/microencapsulated-rabbit-adipose-stem-cells-initiate-tissue-regeneration-in-a-rabbit-ear-defect-model
#9
Shirae K Leslie, David J Cohen, Sharon L Hyzy, Christopher R Dosier, Anthony Nicolini, Janina Sedlaczek, Zvi Schwartz, Barbara D Boyan
Cell-based tissue engineering can promote cartilage tissue regeneration, but cell retention in the implant site post-delivery is problematic. Alginate microbeads containing adipose stem cells (ASCs) pretreated with chondrogenic media (CM) have been used successfully to regenerate hyaline cartilage in critical size defects in rat xiphoid suggesting that they may be used to treat defects in elastic cartilages like the ear. To test this, we used microbeads made with low viscosity, high mannuronate medical grade alginate using a high electrostatic potential and a calcium cross linking solution containing glucose...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29765410/comparison-of-regenerative-tissue-quality-following-matrix-associated-cell-implantation-using-amplified-chondrocytes-compared-to-synovium-derived-stem-cells-in-a-rabbit-model-for-cartilage-lesions
#10
Hagen Schmal, Justyna M Kowal, Moustapha Kassem, Michael Seidenstuecker, Anke Bernstein, Katharina Böttiger, Tanshiyue Xiong, Norbert P Südkamp, Eva J Kubosch
Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in a rabbit, a collagen membrane was seeded with either culture-expanded allogenic chondrocytes or SMSC and then transplanted into the lesion. A tailored piece synovium served as a control. Rabbit SMSC formed typical cartilage in vitro...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29763501/influence-of-lateral-windows-with-decreased-vertical-height-following-maxillary-sinus-floor-augmentation-a-1-year-clinical-and-radiographic-study
#11
Wei Lu, Jin Xu, Hui-Ming Wang, Fu-Ming He
PURPOSE: To verify whether lateral sinus floor elevation (LSFE) with the vertical height of the osteotomy decreased to 3 to 5 mm can achieve improvement compared with a conventional lateral window in terms of implant survival, graft stability, and related complications. MATERIALS AND METHODS: Of the 49 patients who were selected for inclusion in this retrospective study, 25 patients were in the test group and 24 were in the control group based on the vertical height of the lateral window...
May 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29763358/bone-marrow-stimulation-technique-augmented-by-an-ultrapurified-alginate-gel-enhances-cartilage-repair-in-a-canine-model
#12
Rikiya Baba, Tomohiro Onodera, Masatake Matsuoka, Kazutoshi Hontani, Zenta Joutoku, Shinji Matsubara, Kentaro Homan, Norimasa Iwasaki
BACKGROUND: The optimal treatment for a medium- or large-sized cartilage lesion is still controversial. Since an ultrapurified alginate (UPAL) gel enhances cartilage repair in animal models, this material is expected to improve the efficacy of the current treatment strategies for cartilage lesions. HYPOTHESIS: The bone marrow stimulation technique (BMST) augmented by UPAL gel can induce hyaline-like cartilage repair. STUDY DESIGN: Controlled laboratory study...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29761823/erythropoietin-promotes-network-formation-of-transplanted-adipose-tissue-derived-microvascular-fragments
#13
P Karschnia, C Scheuer, A Heß, T Später, M D Menger, M W Laschke
The seeding of tissue constructs with adipose tissue-derived microvascular fragments (ad-MVF) is an emerging pre-vascularisation strategy. Ad-MVF rapidly reassemble into new microvascular networks after in vivo implantation. Herein it was analysed whether this process was improved by erythropoietin (EPO). Ad-MVF were isolated from green fluorescent protein (GFP)+ as well as wild-type C57BL/6 mice and cultivated for 24 h in medium supplemented with EPO (20 IU/mL) or vehicle. Freshly isolated, non-cultivated ad-MVF served as controls...
May 9, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29760942/induction-of-chondrogenesis-of-human-placenta-derived-mesenchymal-stem-cells-via-heparin-grafted-human-fibroblast-derived-matrix
#14
Yong Kwan Noh, Ping Du, Avelino Dos Santos Da Costa, Kwideok Park
Background: Formation of mature and functional articular cartilage is still challenging in cartilage tissue engineering. This study investigates the potential of using heparin-grafted decellularized extracellular matrix (ECM) as a novel growth factor delivery platform towards human placenta-derived mesenchymal stem cells (hPMSCs) chondrogenic differentiation. Human fibroblast-derived extracellular matrix (hFDM) is naturally obtained from in vitro-cultured human lung fibroblasts via a mild decellularization process...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/29757470/sinus-augmentation-using-rhbmp-2-acs-in-a-mini-pig-model-influence-of-an-adjunctive-ceramic-bone-biomaterial
#15
Cristiano Susin, Jaebum Lee, Tiago Fiorini, Rubens Moreno de Freitas, Hsien-Chung Chiu, Hari S Prasad, Amanda N Buxton, Ulf Me Wikesjö
BACKGROUND: Recombinant human bone morphogenetic protein-2 in an absorbable collagen sponge carrier (rhBMP-2/ACS) has been shown to support significant bone formation when used to augment the maxillary sinus for implant dentistry. Nevertheless, bone biomaterials have been suggested to extend rhBMP-2/ACS with limited support of the merits of such approaches. OBJECTIVES: To evaluate local bone formation/dental implant osseointegration following implantation of rhBMP-2/ACS combined with a ceramic bone biomaterial using a mini-pig sinus augmentation model...
May 14, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29756539/skin-regeneration-with-a-scaffold-of-predefined-shape-and-bioactive-peptide-hydrogels
#16
Heejung Im, Su Hee Kim, Soo Hyun Kim, Youngmee Jung
We developed a highly elastic customized scaffold for soft-tissue regeneration and combined them with bioactive hydrogels with stem-cell-inducing ability. This was done to mimic mechanical properties of native soft tissues and improve the viability of transplanted cells as well as efficiency of tissue regeneration. The proposed study was aimed at evaluating various characteristics of scaffolds and investigating their tissue regenerating ability. Finger shaped porous scaffolds were successfully fabricated by an indirect 3D printing of poly (L-lactide-co-ε-caprolactone) (PLCL) which provides a high elasticity for soft tissue engineering...
May 14, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29756517/local-controlled-release-in-vivo-of-vascular-endothelial-growth-factor-within-a-subcutaneous-scaffolded-islet-implant-reduces-early-islet-necrosis-and-improves-performance-of-the-graft
#17
John A Gebe, Anton Preisinger, Michel D Gooden, Leonard A D'Amico, Robert B Vernon
Islet transplantation remains the only alternative to daily insulin therapy for control of type 1 diabetes (T1D) in humans. To avoid the drawbacks of intrahepatic islet transplantation, we are developing a scaffolded islet implant to transplant islets into nonhepatic sites. The implant test bed, sized for mice, consists of a limited (2-mm) thickness, large-pore polymeric sponge scaffold perforated with peripheral cavities that contain islets suspended in a collagen hydrogel. A central cavity in the scaffold holds a 2-mm diameter alginate sphere for controlled release of the angiogenic cytokine vascular endothelial growth factor ( VEGF)...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29756272/harnessing-human-decellularized-blood-vessel-matrices-and-cellular-construct-implants-to-promote-bone-healing-in-an-ex-vivo-organotypic-bone-defect-model
#18
Stefanie Inglis, Karl Heinrich Schneider, Janos M Kanczler, Heinz Redl, Richard O C Oreffo
Decellularized matrices offer a beneficial substitute for biomimetic scaffolds in tissue engineering. The current study examines the potential of decellularized placental vessel sleeves (PVS) as a periosteal protective sleeve to enhance bone regeneration in embryonic day 18 chick femurs contained within the PVS and cultured organotypically over a 10 day period. The femurs are inserted into decellularized biocompatibility-tested PVS and maintained in an organotypic culture for a period of 10 days. In femurs containing decellularized PVS, a significant increase in bone volume (p < 0...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29756213/the-influence-of-different-soft-tissue-grafting-procedures-at-single-implant-placement-on-esthetics-a-randomized-controlled-trial
#19
Elise G Zuiderveld, Henny J A Meijer, Arjan Vissink, Gerry M Raghoebar
BACKGROUND: Soft tissue grafting to thicken the soft tissue around dental implants was proposed to ameliorate the esthetic outcome. Traditionally, connective tissue is used as a grafting material, but a xenogeneic collagen matrix was introduced as an alternative to reduce patient morbidity. METHODS: Sixty patients randomly received either no graft (n = 20, NG group), a connective tissue graft (n = 20, CTG group) or a xenogeneic collagen matrix (n = 20, XCM group) when placing an implant in a preserved alveolar ridge...
May 13, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29756133/biology-of-teeth-and-implants-host-factors-pathology-regeneration-and-the-role-of-stem-cells
#20
F-Michael Eggert, Liran Levin
In chronic periodontitis and peri-implantitis, cells of the innate and adaptive immune systems are involved directly in the lesions within the tissues of the patient. Absence of a periodontal ligament around implants does not prevent a biologic process similar to that of periodontitis from affecting osseointegration. Our first focus is on factors in the biology of individuals that are responsible for the susceptibility of such individuals to chronic periodontitis and to peri-implantitis. Genetic factors are of significant importance in susceptibility to these diseases...
2018: Quintessence International
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