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https://www.readbyqxmd.com/read/28535612/efficient-whole-cell-biocatalyst-for-2-3-butanediol-acetoin-production-with-nadh-nad-regeneration-system-in-engineered-serratia-marcescens
#1
Rao Ben, Truong Ngoc Tu, Fan Ji Ying, Sun Jian An, Yaling Shen
Serratia marcescens is reported to possess the potential for industrial 2,3-butanediol or acetoin production by fermentation. But 2,3-butanediol or acetoin are always co-produced and this may make purification process difficult. So biocatalytic technologies may be the appropriate production methods. In this study, we developed an auto-inducing expression system based on pET system and swr quorum sensing system by using S. marcescens. By using this system, S. marcescens could be engineered as whole-cell biocatalyst to obtain 2,3-butanediol or acetoin...
May 24, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28533393/angular-measurements-of-the-dynein-ring-reveal-a-stepping-mechanism-dependent-on-a-flexible-stalk
#2
Lisa G Lippert, Tali Dadosh, Jodi A Hadden, Vishakha Karnawat, Benjamin T Diroll, Christopher B Murray, Erika L F Holzbaur, Klaus Schulten, Samara L Reck-Peterson, Yale E Goldman
The force-generating mechanism of dynein differs from the force-generating mechanisms of other cytoskeletal motors. To examine the structural dynamics of dynein's stepping mechanism in real time, we used polarized total internal reflection fluorescence microscopy with nanometer accuracy localization to track the orientation and position of single motors. By measuring the polarized emission of individual quantum nanorods coupled to the dynein ring, we determined the angular position of the ring and found that it rotates relative to the microtubule (MT) while walking...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28531454/preliminary-validation-of-the-malay-yale-food-addiction-scale-factor-structure-and-item-analysis-in-an-obese-population
#3
Yogarabindranath Swarna Nantha, Norafidza Ashiquin Abd Patah, Mahalakshmi Ponnusamy Pillai
BACKGROUND AND AIMS: Researchers suggest that the rise in obesity rates may be explained by the addictive properties of certain types of food. In view of the growing obesity epidemic in South-East Asia, there is a need for a psychometric tool to assess the concept of food addiction amongst high-risk populations. The objective of this study is to translate the Yale Food Addiction Scale (YFAS) into the Malay language and subsequently validate its use in an obese population. METHODS: Between the year 2014 and 2015, a total of 250 obese adults were assessed for food addiction utilizing the Malay version of the YFAS at a primary care clinic...
December 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28523393/flavored-anesthetic-masks-for-inhalational-induction-in-children
#4
Aakriti Gupta, Preethy Joseph Mathew, Neerja Bhardwaj
OBJECTIVES: To evaluate the clinical efficacy of masking the odor of inhalational agents using fruit flavors on the anxiety behavior and compliance of children for inhalational induction. METHODS: A prospective randomized double blind, placebo controlled study was conducted on 60 unpremedicated children in the age group of 4-12 y. Thirty children received anesthetic masks smeared with a flavor of child's choice while the other 30 children were induced using masks without flavor...
May 19, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28511949/serum-metal-levels-for-diagnosis-of-adverse-local-tissue-reactions%C3%A2-secondary-to-corrosion-in-metal-on-polyethylene-total%C3%A2-hip%C3%A2-arthroplasty
#5
Yale A Fillingham, Craig J Della Valle, Daniel D Bohl, Mick P Kelly, Deborah J Hall, Robin Pourzal, Joshua J Jacobs
BACKGROUND: Recently, corrosion at the head-neck junction in metal-on-polyethylene bearing surface total hip arthroplasty (THA) has been recognized as a cause of adverse local tissue reactions (ALTRs). Serum metal levels have been advocated as a tool for the diagnosis of ALTR; however, no prior studies have specifically examined their utility. The purpose of this study was to determine the optimal cutoff values for serum cobalt and chromium levels in diagnosing ALTR after metal-on-polyethylene bearing surface THA...
April 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28510792/a-systematic-review-of-proinsulin-secreting-pancreatic-neuroendocrine-tumors
#6
Timothy D Murtha, Beatrice C Lupsa, Sachin Majumdar, Dhanpat Jain, Ronald R Salem
BACKGROUND: Pancreatic neuroendocrine tumors (PNETs) are a heterogeneous group of islet cell-derived neoplasms with a propensity toward hormone production. Among PNETs, proinsulin-secreting tumors (proinsulinomas) are exceedingly rare. The objective of this study is to collect and summarize the existing literature to provide a comprehensive evaluation of this uncommon disease. METHODS: A systematic review was performed to characterize the clinicopathologic features of proinsulinoma...
May 16, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28492062/intraoperative-injection-of-technetium-99m-sulfur-colloid-for-sentinel-lymph-node-biopsy-in-breast-cancer-patients-a-single-institution-experience
#7
Julian Berrocal, Lawrence Saperstein, Baiba Grube, Nina R Horowitz, Anees B Chagpar, Brigid K Killelea, Donald R Lannin
Background. Most institutions require a patient undergoing sentinel lymph node biopsy to go through nuclear medicine prior to surgery to be injected with radioisotope. This study describes the long-term results using intraoperative injection of radioisotope. Methods. Since late 2002, all patients undergoing a sentinel lymph node biopsy at the Yale-New Haven Breast Center underwent intraoperative injection of technetium-99m sulfur colloid. Endpoints included number of sentinel and nonsentinel lymph nodes obtained and number of positive sentinel and nonsentinel lymph nodes...
2017: Surgery Research and Practice
https://www.readbyqxmd.com/read/28487919/nitrogen-doped-porous-carbon-material-derived-from-metal-organic-gel-for-small-biomolecular-sensing
#8
Yung-Han Shih, Jian-Hong Chen, Yaling Lin, Hsin-Tsung Chen, Chia-Her Lin, Hsi-Ya Huang
A simple preparation method of N-doped PCM via direct carbonization of nitrogen containing metal-organic gel was demonstrated. The resultant N-PCM, with high surface area, mesoporosity, and high UV absorption ability, was used as a matrix to assist small-biomolecule sensing in laser desorption/ionization mass spectrometry.
May 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28485008/l-carnosine-as-an-adjuvant-to-fluvoxamine-in-treatment-of-obsessive-compulsive-disorder-a-randomized-double-blind-study
#9
Somaye Arabzadeh, Maryam Shahhossenie, Bita Mesgarpour, Farzin Rezaei, Mohammad Reza Shalbafan, Zahra Ghiasi, Shahin Akhondzadeh
BACKGROUND: Dysregulation of glutamate is implicated in the pathogenesis of obsessive-compulsive disorder (OCD). Consistently, glutamate-modulating agents, such as riluzole and memantine have been used in OCD treatment. Previous research has identified some neuroprotective role for L-carnosine potentially via its modulatory effect on glutamate. Here, we assessed the efficacy of L-carnosine as adjuvant to fluvoxamine in OCD treatment. METHODS: Forty-four patients diagnosed with moderate to severe OCD were recruited in a randomized double-blind trial...
May 8, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28484939/a-systematic-review-of-mobility-immobility-in-thromboembolism-risk-assessment-models-for-hospitalized-patients
#10
REVIEW
Fan Ye, Carolyn Stalvey, Matheen A Khuddus, David E Winchester, Hale Z Toklu, Joseph J Mazza, Steven H Yale
Hospitalized patients are at risk of venous thromboembolism (VTE) and prophylaxis is often suboptimal due to difficulty in identifying at-risk patients. Simple and validated risk-assessment models (RAMs) are available to assist clinicians in identifying patients who have a high risk for developing VTE. Despite the well-documented association of immobility with increased risk of thrombosis, immobility is not consistently defined in clinical studies. We conducted a systematic review of published VTE RAMs and used objective criteria to determine how the term immobility is defined in RAMs...
May 8, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28483079/factor-analysis-of-y-bocs-checklist-and-severity-scale-among-patients-with-schizophrenia
#11
Sandeep Grover, Devakshi Dua, Subho Chakrabarti, Ajit Avasthi
AIM: To carry out factor analysis of YBOCS checklist and YBOCS severity scale among patients with schizophrenia. METHODOLOGY: 181 patients of schizophrenia were assessed on the Yale Brown Obsessive Compulsive Symptom (YBOCS) checklist, YBOCS severity scale and, positive and negative syndrome scale (PANSS). RESULTS: About one fourth (28.18%) of the patients fulfilled the diagnosis of current OCD and 29.83% of patients fulfilled the lifetime diagnosis of OCD...
April 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28482697/biotransformation-enzyme-activities-and-phase-i-metabolites-analysis-in-litopenaeus-vannamei-following-intramuscular-administration-of-t-2-toxin
#12
Yijia Deng, Yaling Wang, Lijun Sun, Pengli Lu, Rundong Wang, Lin Ye, Defeng Xu, Riying Ye, Ying Liu, Siyuan Bi, Ravi Gooneratne
T-2 toxin (T-2) is a type-A trichothecene produced by Fusarium that causes toxicity to animals. T-2 contamination of grain-based aquatic feed is a concern for the industries related to edible aquatic crustacean species such as the shrimp industry because it can lead to serious food safety issues. T-2, its metabolites, and selected phase I (EROD, CarE) and phase II (GST, UGT, SULT) detoxification enzymes in hemolymph and tissues were monitored at 0, 5, 10 15, 30, 45, and 60 min following T-2 intramuscular administration (3 mg/kg bw) in shrimp (Litopenaeus vannamei)...
May 8, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28482070/elevated-%C3%AE-hydroxybutyrate-and-bcaa-levels-predict-deterioration-of-glycemic-control-in-adolescents
#13
Domenico Tricò, Hetty Prinsen, Cosimo Giannini, Robin de Graff, Christoph Juchem, Fangyong Li, Sonia Caprio, Nicola Santoro, Raimund I Herzog
Context: Traditional risk factors for type 2 diabetes mellitus (T2DM) are weak predictors of changes in glucose tolerance and insulin sensitivity in youth. Objective: To identify early metabolic features of insulin resistance in youth and whether they predict deterioration of glycemic control. Design and Setting: A cross-sectional and longitudinal study was conducted at the Yale Pediatric Obesity Clinic. Patients and Intervention: Concentrations of α-hydroxybutyrate, β-hydroxybutyrate, lactate, and branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) were measured by NMR spectroscopy in 78 non-diabetic adolescents during an oral glucose tolerance test (OGTT)...
May 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28481434/time-course-of-the-effects-of-lisdexamfetamine-dimesylate-in-two-phase-3-randomized-double-blind-placebo-controlled-trials-in-adults-with-binge-eating-disorder
#14
Susan L McElroy, James I Hudson, Maria Gasior, Barry K Herman, Jana Radewonuk, Denise Wilfley, Joan Busner
OBJECTIVE: This study examined the time course of efficacy-related endpoints for lisdexamfetamine dimesylate (LDX) versus placebo in adults with protocol-defined moderate to severe binge eating disorder (BED). METHODS: In two 12-week, double-blind, placebo-controlled studies, adults meeting DSM-IV-TR BED criteria were randomized 1:1 to receive placebo or dose-optimized LDX (50 or 70 mg). Analyses across visits used mixed-effects models for repeated measures (binge eating days/week, binge eating episodes/week, Yale-Brown Obsessive Compulsive Scale modified for Binge Eating [Y-BOCS-BE] scores, percentage body weight change) and chi-square tests (Clinical Global Impressions-Improvement [CGI-I; from the perspective of BED symptoms] scale dichotomized as improved or not improved)...
May 8, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28477026/mir-199a-3p-suppresses-proliferation-and-invasion-of-prostate-cancer-cells-by-targeting-smad1
#15
Feng Qu, Jinyu Zheng, Weidong Gan, Huibo Lian, Hua He, Wuping Li, Tian Yuan, Yaling Yang, Xiaogong Li, Changwei Ji, Xiang Yan, Linfeng Xu, Hongqian Guo
OBJECTIVES: This study was intended to analyze effects of miR-199a-3p and Smad1 on proliferation, migration and invasion of prostate cancer (PCa) cells. RESULTS: MiR-199a-3p was significantly decreased in PCa tissues in comparison to that in adjacent normal tissues (P < 0.05). Over-expressed miR-199a-3p markedly suppressed proliferation and invasion of PCa cells (P < 0.05). MiR-199a-3p was negatively correlated with Smad1 expression, and overexpression of Smad1 could antagonize the effects of miR-199a-3p on PCa cells...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28472126/growth-and-adherence-of-staphylococcus-aureus-were-enhanced-through-the-pge2-produced-by-the-activated-cox-2-pge2-pathway-of-infected-oral-epithelial-cells
#16
Yuxia Wang, Biao Ren, Xuedong Zhou, Shiyu Liu, Yujie Zhou, Bolei Li, Yaling Jiang, Mingyun Li, Mingye Feng, Lei Cheng
Staphylococcus aureus is a major pathogen of varieties of oral mucous infection. Prostaglandin E2 (PGE2) is a pro-inflammatory factor and Cyclooxygenase 2 (COX-2) is a critical enzyme of PGE2 biosynthesis. The purpose of this study is to investigate whether Staphylococcus aureus can increase PGE2 production of oral epithelial cells and how PGE2 functions in the growth and adherence of Staphylococcus aureus. mRNA levels of COX-2, fnbpA and fnbpB were estimated by quantitative PCR. PGE2 production was measured by Enzyme Linked Immunosorbent Assay (ELISA)...
2017: PloS One
https://www.readbyqxmd.com/read/28469594/action-tremor-asymmetry-profile-does-not-aggregate-in-families-with-essential-tremor
#17
Elan D Louis, Nora Hernandez, Karen P Chen, Kelly V Naranjo, Jemin Park, Lorraine N Clark, Ruth Ottman
BACKGROUND: Action tremor is the hallmark feature of essential tremor (ET). While the tremor typically is mildly asymmetric, in some patients, it is markedly asymmetric. There are few data on factors that influence this asymmetry. ET is also a highly familial disease. Whether the tremor asymmetry profile (i.e., differential expression of tremor in each arm in a given patient) is similar across family members is not known. The alternative possibility is that this feature is not heritable...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28465792/effects-of-intermittent-fasting-on-health-markers-in-those-with-type-2-diabetes-a-pilot-study
#18
Terra G Arnason, Matthew W Bowen, Kerry D Mansell
AIM: To determine the short-term biochemical effects and clinical tolerability of intermittent fasting (IF) in adults with type 2 diabetes mellitus (T2DM). METHODS: We describe a three-phase observational study (baseline 2 wk, intervention 2 wk, follow-up 2 wk) designed to determine the clinical, biochemical, and tolerability of IF in community-dwelling volunteer adults with T2DM. Biochemical, anthropometric, and physical activity measurements (using the Yale Physical Activity Survey) were taken at the end of each phase...
April 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28465131/pocket-money-eating-behaviors-and-weight-status-among-chinese-children-the-childhood-obesity-study-in-china-mega-cities
#19
Miao Li, Hong Xue, Peng Jia, Yaling Zhao, Zhiyong Wang, Fei Xu, Youfa Wang
Both the obesity rate and pocket money are rising among children in China. This study examined family correlates of children's pocket money, associations of pocket money with eating behaviors and weight status, and how the associations may be modified by schools' unhealthy food restrictions in urban China. Data were collected in 2015 from 1648 students in 16 primary and middle schools in four mega-cities in China (4 schools/city): Beijing, Shanghai, Nanjing, and Xi'an. Cluster robust negative binomial regression models were fit to assess family correlates of pocket money, associations of pocket money with child eating behaviors and weight outcomes, and possible modifying effects of schools' unhealthy food restrictions...
April 29, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28464252/long-noncoding-rna-lncarsr-promotes-doxorubicin-resistance-in-hepatocellular-carcinoma-via-modulating-pten-pi3k-akt-pathway
#20
Yaling Li, Yun Ye, Bimin Feng, Yan Qi
Hepatocellular carcinoma (HCC) is generally resistant to chemotherapy due to intrinsic or acquired drug resistances. Many molecules and signaling pathways are involved in chemo-resistance of HCC cells. However, the contribution of long noncoding RNA (lncRNA) to chemo-resistance of HCC cells is still largely unknown. In this study, we revealed the critical roles of long noncoding RNA lncARSR in chemo-resistance of HCC cells. lncARSR is upregulated in HCC, associated with large tumor size and advanced BCLC stage, and indicts poor prognosis...
May 2, 2017: Journal of Cellular Biochemistry
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