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https://www.readbyqxmd.com/read/29334657/relationship-of-obsessive-compulsive-symptoms-to-clinical-variables-and-cognitive-functions-in-individuals-at-ultra-high-risk-for-psychosis
#1
Ahmet Zihni Soyata, Selin Akışık, Damla İnhanlı, Handan Noyan, Alp Üçok
Few studies have investigated the relationship between obsessive-compulsive symptoms (OCS) and clinical variables, and cognition in individuals at ultra high-risk (UHR) for psychosis. The aim of this study was to evaluate the frequency of OCS and their relationship with clinical variables and cognitive functions in individuals at UHR. Eighty-four individuals at UHR for psychosis were administered the Brief Psychiatric Rating Scale, the Yale-Brown Obsession Compulsion Symptom Check List and, the Calgary Depression Scale for Schizophrenia...
January 6, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29333203/biomimetic-microfluidic-platform-for-the-quantification-of-transient-endothelial-monolayer-permeability-and-therapeutic-transport-under-mimicked-cancerous-conditions
#2
Christopher George Uhl, Vladimir R Muzykantov, Yaling Liu
Therapeutic delivery from microvasculature to cancerous sites is influenced by many factors including endothelial permeability, vascular flow rates/pressures, cancer secretion of cytokines and permeabilizing agents, and characteristics of the chosen therapeutics. This work uses bi-layer microfluidics capable of studying dye and therapeutic transport from a simulated vessel to a cancerous region while allowing for direct visualization and quantification of endothelial permeability. 2.5 to 13 times greater dye transport was observed when utilizing small dye sizes (FITC) when compared to larger molecules (FITC-Dextran 4 kDa and FITC-Dextran 70 kDa), respectively...
January 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29332631/treatment-utilization-and-barriers-to-treatment-among-individuals-with-olfactory-reference-syndrome-ors
#3
Jennifer L Greenberg, Noah C Berman, Valerie Braddick, Rachel Schwartz, Suraj S Mothi, Sabine Wilhelm
OBJECTIVE: Olfactory reference syndrome (ORS) is characterized by a preoccupation that one is emitting a foul or offensive odor. Despite the profound psychosocial impact of ORS, many patients do not receive appropriate treatment, and there is no empirical research on treatment-seeking behavior in ORS. This study investigated treatment utilization patterns and barriers to treatment in individuals with ORS. METHOD: 253 subjects completed an online survey between January-March 2010...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29331759/astragaloside-iv-inhibits-cell-migration-and-viability-of-hepatocellular-carcinoma-cells-via-suppressing-long-noncoding-rna-atb
#4
Yaling Li, Yun Ye, Hongyan Chen
Astragaloside IV (AS-IV), the major active component of Astragalus membranaceus, has shown attractive anticancer effects in certain cancers. However, the roles and action mechanisms of AS-IV in hepatocellular carcinoma (HCC) are largely unclear. Long noncoding RNAs (lncRNAs) are recently revealed to have crucial roles in HCC initiation and progression, but whether lncRNAs participate in the anticancer roles of AS-IV are unknown. In this study, we demonstrated that AS-IV significantly downregulated lncRNA-ATB expression in a dose- and time-dependent manner in HCC cells...
January 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29330049/the-histone-demethylase-phf8-promotes-adult-acute-lymphoblastic-leukemia-through-interaction-with-the-mek-erk-signaling-pathway
#5
Yue Fu, Yaling Yang, Xiaoming Wang, Xiaolin Yin, Minran Zhou, Siqi Wang, Lin Yang, Tao Huang, Man Xu, Chunyan Chen
Adult acute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid progenitor cells that is associated with a high risk of relapse and poor prognosis. Thus, novel pathogenic mechanisms and therapeutic targets need to be explored. Histone methylation is one of the most significant chromatin post-translational modifications. Here, we show that the histone demethylase PHF8 is highly expressed in a large number of ALL clinical specimens and that PHF8 expression is associated with ALL progression. PHF8 knockdown inhibits proliferation and promotes the apoptosis of ALL cells in vitro as well as attenuates tumor growth in vivo...
January 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29327438/establishing-rna-virus-resistance-in-plants-by-harnessing-crispr-immune-system
#6
Tong Zhang, Qiufeng Zheng, Xin Yi, Hong An, Yaling Zhao, Siqi Ma, Guohui Zhou
Recently, CRISPR-Cas (clustered, regularly interspaced short palindromic repeats-CRISPR associated proteins) system has been used to produce plants resistant to DNA virus infections. However, there is no RNA virus control method in plants that uses CRISPR-Cas system to target the viral genome directly. Here we reprogrammed the CRISPR-Cas9 system from Francisella novicida to confer molecular immunity against RNA viruses in Nicotiana benthamiana and Arabidopsis plants. Plants expressing FnCas9 and sgRNA specific for the cucumber mosaic virus (CMV) or tobacco mosaic virus (TMV) exhibited significantly attenuated virus infection symptoms and reduced viral RNA accumulation...
January 11, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29325470/the-effect-of-shorter-exposure-versus-prolonged-exposure-on-treatment-outcome-in-tourette-syndrome-and-chronic-tic-disorders-an-open-trial
#7
Jolande M T M van de Griendt, Maarten K van Dijk, Cara W J Verdellen, Marc J P M Verbraak
BACKGROUND: Exposure and response prevention has shown to be an effective strategy and is considered a first-line intervention in the behavioural treatment of tic disorders. Prior research demonstrated significant tic reduction after 12 two hour sessions. OBJECTIVE: In this open trial, the question is addressed whether, relative to these prolonged sessions, exposure sessions of shorter duration yield differential outcome for patients with tic disorders. METHODS: A total of 29 patients diagnosed with Tourette syndrome (TS) or chronic tic disorder were treated with shorter exposure sessions (1 h), and these data were compared to the data from a study about prolonged exposure (2 h, n = 21)...
January 11, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29324492/life-cycle-assessment-and-costing-methods-for-device-procurement-comparing-reusable-and-single-use-disposable-laryngoscopes
#8
Jodi D Sherman, Lewis A Raibley, Matthew J Eckelman
BACKGROUND: Traditional medical device procurement criteria include efficacy and safety, ease of use and handling, and procurement costs. However, little information is available about life cycle environmental impacts of the production, use, and disposal of medical devices, or about costs incurred after purchase. Reusable and disposable laryngoscopes are of current interest to anesthesiologists. Facing mounting pressure to quickly meet or exceed conflicting infection prevention guidelines and oversight body recommendations, many institutions may be electively switching to single-use disposable (SUD) rigid laryngoscopes or overcleaning reusables, potentially increasing both costs and waste generation...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29322619/randomized-comparison-of-novel-biodegradable-polymer-and-durable-polymer-coated-cobalt-chromium-sirolimus-eluting-stents-three-year-outcomes-of-the-i-love-it-2-trial
#9
Lei Song, Jing Li, Changdong Guan, Quanmin Jing, Shuzheng Lu, Lixia Yang, Kai Xu, Yuejin Yang, Bo Xu, Yaling Han
OBJECTIVES: We aimed to compare the long-term outcomes of the novel biodegradable polymer cobalt-chromium sirolimus-eluting stent (BP-SES) versus the durable polymer sirolimus-eluting stent (DP-SES) in the I-LOVE-IT2 trial. BACKGROUNDS: Comparisons of the long-term safety and efficiency of the BP-DES versus the DP-DES are limited. METHODS: A total of 2,737 patients eligible for coronary stenting were randomized to the BP-SES or DP-SES group at a 2:1 ratio...
January 11, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29322242/utility-of-fosfomycin-as-antibacterial-prophylaxis-in-patients-with-hematologic-malignancies
#10
Tanya Zapolskaya, Sarah Perreault, Dayna McManus, Jeffrey E Topal
PURPOSE: Prolonged and profound neutropenia is common among hematology and hematopoietic stem cell transplant (HSCT) patients as a result of chemotherapy. The National Comprehensive Cancer Network (NCCN) and Infectious Diseases Society of America (IDSA) currently recommend antibacterial prophylaxis in patients who are deemed at intermediate or high risk for infection. Specifically, fluoroquinolone prophylaxis should be considered for high-risk neutropenic patients. However, with prolonged and frequent exposure to fluoroquinolones, these high-risk patients may develop resistance to these agents...
January 10, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29321703/executive-functions-of-obsessive-compulsive-disorder-and-panic-disorder-patients-in-comparison-to-healty-controls
#11
Emel Kurt, Erol Yildirim, Volkan Topçuoğlu
Introduction: Patients with obsessive compulsive disorder (OCD) have impaired cognitive functions, including attention, verbal and visual memory, and visual-spatial abilities as well as executive function But some studies did not show any disturbance in executive function of patients with OCD. To date, only few studies have been conducted on neuropsychological functioning of patients with panic disorder (PD). There are limited studies to reach a definite conclusion on executive functions of patients with OCD and those with PD...
December 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29316227/a-convenient-ultrasound-assisted-saponification-for-the-simultaneous-determination-of-vitamin-e-isomers-in-vegetable-oil-by-hplc-with-fluorescence-detection
#12
Yi Yang, Dan Lu, Shuo Yin, Danni Yang, Yaling Chen, Yongxin Li, Chengjun Sun
An efficient ultrasound-assisted saponification was developed for simultaneous determination of vitamin E isomers in vegetable oil by high-performance liquid chromatography with fluorescence detection. The samples were saponified ultrasonically with potassium hydroxide solution for only 7 min, then the analytes were extracted with ether. Vitamin E isomers were separated on a C18 column at 25°C with a mobile phase of methanol/acetonitrile (81:19, v/v) at a flow rate of 0.8 mL min-1 . Fluorescence detection was operated at 290 nm of excitation wavelength and 327 nm of emission wavelength...
January 8, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29315426/an-e-learning-module-on-chronic-low-back-pain-in-older-adults-effect-on-medical-resident-attitudes-confidence-knowledge-and-clinical-skills
#13
Zachary G Jacobs, D Michael Elnicki, Subashan Perera, Debra K Weiner
Objective: To determine 1) the feasibility of implementing an e-learning module on chronic low back pain (CLBP) in an older adult into an existing internal medicine residency curriculum and 2) the impact of this module on resident attitudes, confidence, knowledge, and clinical skills relating to CLBP. Methods: Participants were assigned to complete either the online module (N = 73) or the Yale Office-based curriculum on CLBP (N = 70). Attitudes, confidence, and knowledge were evaluated pre- and postintervention via survey...
January 5, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29314592/impact-of-sleep-deprivation-on-the-outcomes-of-percutaneous-coronary-intervention
#14
Ann Iverson, Larissa Stanberry, Ross Garberich, Amber Antos, Yader Sandoval, M Nicholas Burke, Ivan Chavez, Mario Gössl, Timothy D Henry, Daniel Lips, Michael Mooney, Anil Poulose, Paul Sorajja, Jay Traverse, Yale Wang, Steven Bradley, Emmanouil S Brilakis
No abstract text is available yet for this article.
January 3, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29314499/motivation-but-not-valence-modulates-neuroticism-dependent-cingulate-cortex-and-insula-activity
#15
Yaling Deng, Shijia Li, Renlai Zhou, Martin Walter
Neuroticism has been found to specifically modulate amygdala activations during differential processing of valence and motivation while other brain networks yet are unexplored for associated effects. The main purpose of this study was to investigate whether neural mechanisms processing valence or motivation are prone to neuroticism in the salience network (SN), a network that is anchored in the anterior cingulate cortex (ACC) and the anterior insula. This study used functional magnetic resonance imaging (fMRI) and an approach/avoid emotional pictures task to investigate brain activations modulated by pictures' valence or motivational status between high and low neurotic individuals...
January 4, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29307059/application-of-magnetic-nanoparticles-coated-with-sodium-dodecyl-sulfate-and-modified-with-2-5-bromo-2-pyridylazo-5-diethyl-aminophenol-as-a-novel-adsorbent-for-dispersive-magnetic-solid-phase-extraction-and-determination-of-palladium-in-soil-samples
#16
Meng Wang, Lan Wu, Qiufen Hu, Yaling Yang
A rapid, sensitive, precise, and accurate dispersive-magnetic solid-phase extraction technique combined with flame atomic absorption spectrometry was established for pre-concentration and separation of Pd (II) in soil samples. In the developed system, 5-amine-1,10-phenanthroline was used as synergistic complexant; sodium dodecyl sulfate and 2-(5-bromo-2-pyridylazo)-5-diethyl aminophenol ligand coated on magnetic nanoparticles were synthesized by a chemical precipitation method, and then employed as the efficient magnetic adsorbent with good magnetic properties and dispersibility...
January 6, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29304426/relationship-between-childhood-trauma-and-suicide-probability-in-obsessive-compulsive-disorder
#17
Rukiye Ay, Lale Gonenir Erbay
The aim of this study is to assess the relationship between childhood trauma with the probability of suicide in obsessive compulsive disorders. Sixty-seven patients who were diagnosed with OCD were included in the study out of the patients who were admitted to Malatya Training and Research Hospital psychiatry outpatient clinic. The research data were collected using Yale Brawn Obsessive Compulsive Scale (YBOCS), Beck Depression (BDS) and Beck Anxiety Scales (BAS), Childhood Trauma Questionnaire-28 (CTQ-28), and Suicide Probability Scale (SPS)...
December 27, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29304353/yale-cancer-center-precision-medicine-tumor-board-two-patients-one-targeted-therapy-different-outcomes
#18
Michael Cecchini, Zenta Walther, Jeffrey L Sklar, Ranjit S Bindra, Daniel P Petrylak, Joseph P Eder, Sarah B Goldberg
No abstract text is available yet for this article.
January 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29304351/introduction-to-the-yale-precision-medicine-tumor-board
#19
Michael Cecchini, Zenta Walther, Jeffrey L Sklar, Ranjit S Bindra, Daniel P Petrylak, Joseph P Eder, Sarah B Goldberg
No abstract text is available yet for this article.
January 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29302747/cytokine-chemokine-and-bdnf-levels-in-medication-free-pediatric-patients-with-obsessive-compulsive-disorder
#20
Rukiye Çolak Sivri, Ayhan Bilgiç, İbrahim Kılınç
The aim of this study was to investigate whether the serum levels of IL-12, IL-17, TGFβ, TNF-alpha, sTNFR1, sTNFR2, IL-1β, CCL3, CCL24, CXCL8, and BDNF are associated with obsessive-compulsive disorder (OCD) in medication-free children. A total of 44 (22 boys/22 girls) medication-free children with OCD and 40 (23 boys/17 girls) healthy controls were included in this study. The severity of the OCD symptoms were assessed by the Children's Yale-Brown Obsessive-Compulsive Scale and the Maudsley Obsessive-Compulsive Inventory...
January 4, 2018: European Child & Adolescent Psychiatry
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