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https://www.readbyqxmd.com/read/28439828/interrogation-of-functional-mirna-target-interactions-by-crispr-cas9-genome-engineering
#1
Yale S Michaels, Qianxin Wu, Tudor A Fulga
Post-transcriptional silencing by microRNAs (miRNAs) is a critical constituent of eukaryotic gene regulation. miRNAs are short (~22nt) noncoding RNAs capable of specifically targeting the miRNA-induced-silencing-complex (miRISC) to transcripts bearing a complementary miRNA response element (MRE). Although recent methodological advances have greatly improved our understanding of miRNA biogenesis and the mechanisms by which miRNAs repress their cognate targets, exploring the physiological relevance of direct miRNA-target interactions in vivo has remained an outstanding challenge...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28437147/comparison-of-two-types-of-meditation-on-patients-psychosocial-responses-during-radiation-therapy-for-head-and-neck-cancer
#2
Gisela Boxleitner, Shelley Jolie, Dana Shaffer, Nicholas Pasacreta, Mei Bai, Ruth McCorkle
OBJECTIVES: Radiation treatment for head and neck cancer introduces adaptive demands and subjects patients to significant and unique psychosocial challenges. There is growing evidence that meditation is useful in lessening anxiety and depression in cancer patients. This study compared the effects of two types of meditation training on the psychological responses of patients with head and neck cancer during radiation therapy. DESIGN: Randomized clinical trial. SETTING: Smilow Cancer Hospital at Yale New Haven...
February 17, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28436935/tnf-superfamily-receptor-ox40-triggers-invariant-nkt-cell-pyroptosis-and-liver-injury
#3
Peixiang Lan, Yihui Fan, Yue Zhao, Xiaohua Lou, Howard P Monsour, Xiaolong Zhang, Yongwon Choi, Yaling Dou, Naoto Ishii, Rafik M Ghobrial, Xiang Xiao, Xian Chang Li
Tissue-resident immune cells play a key role in local and systemic immune responses. The liver, in particular, hosts a large number of invariant natural killer T (iNKT) cells, which are involved in diverse immune responses. However, the mechanisms that regulate survival and homeostasis of liver iNKT cells are poorly defined. Here we have found that liver iNKT cells constitutively express the costimulatory TNF superfamily receptor OX40 and that OX40 stimulation results in massive pyroptotic death of iNKT cells, characterized by the release of potent proinflammatory cytokines that induce liver injury...
April 24, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28436892/godec-fast-and-robust-low-rank-matrix-decomposition-based-on-maximum-correntropy
#4
Kailing Guo, Liu Liu, Xiangmin Xu, Dong Xu, Dacheng Tao
GoDec is an efficient low-rank matrix decomposition algorithm. However, optimal performance depends on sparse errors and Gaussian noise. This paper aims to address the problem that a matrix is composed of a low-rank component and unknown corruptions. We introduce a robust local similarity measure called correntropy to describe the corruptions and, in doing so, obtain a more robust and faster low-rank decomposition algorithm: GoDec+. Based on half-quadratic optimization and greedy bilateral paradigm, we deliver a solution to the maximum correntropy criterion (MCC)-based low-rank decomposition problem...
April 24, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28434177/eating-disorders-and-food-addiction-in-men-with-heroin-use-disorder-a-controlled-study
#5
Fatih Canan, Servet Karaca, Suna Sogucak, Omer Gecici, Murat Kuloglu
PURPOSE: We aimed to determine the prevalence estimates of binge eating disorder, bulimia nervosa, anorexia nervosa, and food addiction in men with heroin use disorder and a matched sample of control participants. METHODS: A group of 100 men with heroin use disorder, consecutively admitted to a detoxification and therapy unit, were screened for DSM-5 eating disorders, along with a group of 100 male controls of similar age, education, and body mass index. The Yale Food Addiction Scale (YFAS), the Barratt Impulsivity Scale-version 11, and the Eating Attitudes Test were used for data collection...
April 22, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28427576/bleeding-related-deaths-in-relation-to-the-duration-of-dual-antiplatelet-therapy-after-coronary-stenting
#6
Tullio Palmerini, Letizia Bacchi Reggiani, Diego Della Riva, Mattia Romanello, Fausto Feres, Alexandre Abizaid, Martine Gilard, Marie-Claude Morice, Marco Valgimigli, Myeong-Ki Hong, Byeong-Keuk Kim, Yangsoo Jang, Hyo-Soo Kim, Kyung Woo Park, Antonio Colombo, Alaide Chieffo, Jung-Min Ahn, Seung-Jung Park, Stefanie Schüpke, Adnan Kastrati, Gilles Montalescot, Philippe Gabriel Steg, Abdourahmane Diallo, Eric Vicaut, Gerard Helft, Giuseppe Biondi-Zoccai, Bo Xu, Yaling Han, Philippe Genereux, Deepak L Bhatt, Gregg W Stone
BACKGROUND: Although some randomized controlled trials (RCTs) and meta-analyses have suggested that prolonged dual-antiplatelet therapy (DAPT) may be associated with increased mortality, the mechanistic underpinnings of this association remain unclear. OBJECTIVES: The aim of this study was to analyze the associations among bleeding, mortality, and DAPT duration after drug-eluting stent implantation in a meta-analysis of RCTs. METHODS: RCTs comparing different DAPT durations after drug-eluting stent placement were sought through the MEDLINE, Embase, and Cochrane databases and the proceedings of international meetings...
April 25, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28424218/gop-1-promotes-apoptotic-cell-degradation-by-activating-the-small-gtpase-rab2-in-c-elegans
#7
Jianhua Yin, Yaling Huang, Pengfei Guo, Siqi Hu, Sawako Yoshina, Nan Xuan, Qiwen Gan, Shohei Mitani, Chonglin Yang, Xiaochen Wang
Apoptotic cells generated by programmed cell death are engulfed by phagocytes and enclosed within plasma membrane-derived phagosomes. Maturation of phagosomes involves a series of membrane-remodeling events that are governed by the sequential actions of Rab GTPases and lead to formation of phagolysosomes, where cell corpses are degraded. Here we identified gop-1 as a novel regulator of apoptotic cell clearance in Caenorhabditis elegans Loss of gop-1 affects phagosome maturation through the RAB-5-positive stage, causing defects in phagosome acidification and phagolysosome formation, phenotypes identical to and unaffected by loss of unc-108, the C...
April 19, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28419223/removal-of-batch-effects-using-distribution-matching-residual-networks
#8
Uri Shaham, Kelly P Stanton, Jun Zhao, Huamin Li, Khadir Raddassi, Ruth Montgomery, Yuval Kluger
Motivation: Sources of variability in experimentally derived data include measurement error in addition to the physical phenomena of interest. This measurement error is a combination of systematic components, originating from the measuring instrument, and random measurement errors. Several novel biological technologies, such as mass cytometry and single-cell RNA-seq, are plagued with systematic errors that may severely affect statistical analysis if the data is not properly calibrated...
April 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28414617/theorizing-the-impact-of-targeted-narratives-model-admiration-and-narrative-memorability
#9
Katheryn R Christy, Jakob D Jensen, Susan H Sarapin, Robert N Yale, Jeremy Weaver, Manusheela Pokharel
Communication campaigns often include components that have been designed for a specific population, a strategy referred to as targeting. Targeted narratives are story-based components of a campaign that feature a character or situation relevant to the intended audience. Though commonplace, few studies have explicated the underlying mechanisms by which targeted narratives exert influence. In a message evaluation study, 316 women aged 40-75 (Mage = 51.19, SD = 8.11) were exposed to one of two targeted narratives and asked to complete measures of model admiration, narrative memorability, and intentions to receive a mammography...
May 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28410588/evidence-synthesis-to-inform-model-based-cost-effectiveness-evaluations-of-diagnostic-tests-a-methodological-review-of-health-technology-assessments
#10
Bethany Shinkins, Yaling Yang, Lucy Abel, Thomas R Fanshawe
BACKGROUND: Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from various sources to be incorporated and enable cost-effectiveness estimates to be made beyond the duration of available study data. To parameterize a health-economic model fully, all the ways a test impacts on patient health must be quantified, including but not limited to diagnostic test accuracy...
April 14, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28410106/structured-sparse-subspace-clustering-a-joint-affinity-learning-and-subspace-clustering-framework
#11
Chun-Guang Li, Chong You, Rene Vidal
Subspace clustering refers to the problem of segmenting data drawn from a union of subspaces. State-of-the-art approaches for solving this problem follow a two-stage approach. In the first step, an affinity matrix is learned from the data using sparse or low-rank minimization techniques. In the second step, the segmentation is found by applying spectral clustering to this affinity. While this approach has led to state-of-the-art results in many applications, it is sub-optimal because it does not exploit the fact that the affinity and the segmentation depend on each other...
April 6, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28407228/deleterious-protein-altering-mutations-in-the-scn10a-voltage-gated-sodium-channel-gene-are-associated-with-prolonged-qt
#12
Maen D Abou Ziki, Sara B Seidelmann, Emily Smith, Gourg Atteya, Yuexin Jiang, Rodolfo Gil Fernandes, Mark A Marieb, Joseph G Akar, Arya Mani
Long QT syndrome (LQT) is a pro-arrhythmogenic condition with life threatening complications. Fifteen genes have been associated with congenital LQT however, the genetic causes remain unknown in more than 20% of cases. Eighteen patients with history of palpitations, presyncope, syncope and prolonged QT were referred to the Yale Cardiovascular Genetics Program. All subjects underwent whole exome sequencing (WES) followed by confirmatory Sanger sequencing. Mutation burden analysis was carried out using WES data from sixteen subjects with no identifiable cause of LQT...
April 13, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28402068/eating-related-psychopathology-and-food-addiction-in-adolescent-psychiatric-inpatients
#13
Özgür Albayrak, Manuel Föcker, Josephine Kliewer, Simon Esber, Triinu Peters, Martina de Zwaan, Johannes Hebebrand
OBJECTIVE: Our aims were to investigate the relationship between food addiction and mental disorders including eating disorders (ED), eating-related psychopathology and body mass index-standard deviation score in a sample of adolescent psychiatric inpatients. METHODS: Food addiction was assessed with the Yale Food Addiction Scale (YFAS). Eating-related psychopathology was measured with the Three-Factor Eating Questionnaire (TFEQ). Psychiatric diagnoses were assessed according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition...
May 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28390444/the-relationship-between-obsessive-compulsive-personality-and-obsessive-compulsive-disorder-treatment-outcomes-predictive-utility-and-clinically-significant-change
#14
Shalane K Sadri, Peter M McEvoy, Sarah J Egan, Robert T Kane, Clare S Rees, Rebecca A Anderson
BACKGROUND: The evidence regarding whether co-morbid obsessive compulsive personality disorder (OCPD) is associated with treatment outcomes in obsessive compulsive disorder (OCD) is mixed, with some research indicating that OCPD is associated with poorer response, and some showing that it is associated with improved response. AIMS: We sought to explore the role of OCPD diagnosis and the personality domain of conscientiousness on treatment outcomes for exposure and response prevention for OCD...
April 9, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28389703/use-of-subconjunctival-injections-of-5-fluorouracil-to-rescue-and-prolong-intraocular-pressure-reduction-for-a-failing-ahmed-glaucoma-implant
#15
Kevin Kaplowitz, Sarah Khodadadeh, Samantha Wang, Daniel Lee, James C Tsai
PURPOSE: 5-Fluorouracil (5-FU) has been well described for a failing trabeculectomy bleb, but not for aqueous shunts. We sought to determine whether subconjunctival 5-FU prolongs the intraocular pressure (IOP) efficacy of Ahmed shunts. METHODS: We included all patients with Ahmed FP-7 implantation by one surgeon at Yale University. Patients with <3 months follow-up were excluded. Injections were done on a case-by-case basis, usually for IOP > 21 on >2 medications...
April 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28387621/deep-brain-stimulation-for-tourette-syndrome-a-single-center-series
#16
Richard S Dowd, Michael Pourfar, Alon Y Mogilner
OBJECTIVE Tourette syndrome (TS) is a complex neuropsychiatric disorder characterized by multiple motor and phonic tics. While pharmacological and behavioral therapy can be effective in most patients, a subset of patients remains refractory to treatment. Increasing clinical evidence from multiple centers suggests that deep brain stimulation (DBS) of the medial thalamus can be effective in many cases of refractory TS. METHODS The authors retrospectively reviewed outcomes in 13 patients with refractory TS who underwent medial thalamic DBS performed by their team over a 7-year period...
April 7, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28385581/self-perceived-food-addiction-prevalence-predictors-and-prognosis
#17
Angela Meadows, Laurence J Nolan, Suzanne Higgs
Food addiction is controversial within the scientific community. However many lay people consider themselves addicted to certain foods. We assessed the prevalence and characteristics of self-perceived "food addiction" and its relationship to a diagnostic measure of "clinical food addiction" in two samples: (1) 658 university students, and (2) 614 adults from an international online crowdsourcing platform. Participants indicated whether they considered themselves to be addicted to food, and then completed the Yale Food Addiction Scale, measures of eating behavior, body image, and explicit and internalized weight stigma...
April 3, 2017: Appetite
https://www.readbyqxmd.com/read/28382063/the-effects-of-preanesthetic-parental-presence-on-preoperative-anxiety-of-children-and-their-parents-a-randomized-clinical-trial-study-in-iran
#18
Razie Rasti-Emad-Abadi, Abbas Naboureh, Morteza Nasiri, Nilofar Motamed, Faezeh Jahanpour
INTRODUCTION: Parental presence during induction of anesthesia (PPIA) has been a controversial issue, with some studies showing its effects on reducing anxiety. Hence, this study aimed to investigate the effects of PPIA on preoperative anxiety of children as well as their parents. MATERIALS AND METHODS: This clinical trial was conducted among 60 children aged 2-10 years and their parents. Children were randomly assigned to intervention (n = 30) and control (n = 30) groups...
January 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28377782/species-delimitation-and-lineage-separation-history-of-a-species-complex-of-aspens-in-china
#19
Honglei Zheng, Liqiang Fan, Richard I Milne, Lei Zhang, Yaling Wang, Kangshan Mao
Species delimitation in tree species is notoriously challenging due to shared polymorphisms among species. An integrative survey that considers multiple operational criteria is a possible solution, and we aimed to test it in a species complex of aspens in China. Genetic [four chloroplast DNA (cpDNA) fragments and 14 nuclear microsatellite loci (nSSR)] and morphological variations were collected for 76 populations and 53 populations, respectively, covering the major geographic distribution of the Populus davidiana-rotundifolia complex...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28377683/interinstitutional-collaboration-for-end-user-bioinformatics-training-cytoscape-as-a-case-study
#20
Marci D Brandenburg, Rolando Garcia-Milian
BACKGROUND: This case study describes the value of and need for interinstitutional collaboration to train biomedical researchers in data visualization, using Cytoscape network analysis software as an example. To provide training on Cytoscape software to Yale University biomedical researchers, a collaboration was formed between the Yale Harvey Cushing/John Hay Whitney Medical Library's (CWML's) biomedical sciences research support librarian and the University of Michigan (U-M) Taubman Health Sciences Library's bioinformationist, who has expertise in Cytoscape software...
April 2017: Journal of the Medical Library Association: JMLA
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