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https://www.readbyqxmd.com/read/28318138/safety-and-efficacy-of-6-month-versus-12-month-dual-antiplatelet-therapy-in-patients-after-implantation-of-multiple-biodegradable-polymer-coated-sirolimus-eluting-coronary-stents-insight-from-the-i-love-it-2-trial
#1
Jing Qi, Yi Li, Jing Li, Quanmin Jing, Kai Xu, Chuanyu Gao, Likun Ma, Zhi Zhang, Bo Xu, Yaling Han
OBJECTIVE: This study sought to compare the clinical outcomes of 6-month versus 12-month dual antiplatelet therapy (DAPT) in patients receiving multiple biodegradable polymer-coated sirolimus-eluting stents (BP-SES) implants. BACKGROUND: The clinical outcomes for patients who undergo multiple BP-SES implantation with different DAPT durations are uncertain. METHODS: In the I-LOVE-IT 2 trial, 907 patients treated with multiple BP-SES (total stent number ≥2) were assigned to receive 6-month (n = 440) or 12-month (n = 467) DAPT...
March 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28317515/howard-wilcox-haggard-and-the-institutionalization-of-modern-alcohol-studies
#2
Nicholas Allred, William Bejarano, Judit Ward
OBJECTIVE: This biographical sketch and accompanying bibliography provide a new look at Howard Wilcox Haggard, M.D., Ph.D., whose career highlights the consolidation of alcohol studies as a field in twentieth-century America. METHOD: The article relies in large part on the works of Haggard assembled for the bibliography project, supplemented by published and unpublished documents and records from collections at Rutgers University. RESULTS: Haggard began his career in respiratory physiology, influenced by his work on chemical weapons for the Army during the First World War...
March 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28317369/a-visual-chronometric-assay-for-chromium-iii-ions-based-on-cu2o-nanocubes-mediated-clock-reaction
#3
Lei Zheng, Haili Yu, Yaling Yue, Fengjuan Wu, Yi He
We report a visual chronometric assay for Cr3+ based on Cu2O nanocubes-mediated clock reaction of methylene blue (MB) and N2H4. The MB with a blue color can be easily reduced by excess N2H4 to form colorless leuco-MB (LMB) in the presence of Cu2O nanocubes as a catalyst in a short time. However, the addition of Cr3+ decreases the catalytic activity of Cu2O nanocubes owing to the coordination interactions between them, leading to a long reaction time. The value of reaction time change was employed for selective detection of Cr3+...
March 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28315821/1-3-propanediol-production-by-a-newly-isolated-strain-clostridium-perfringens-gyl
#4
Yali Guo, Lu Dai, Bo Xin, Fei Tao, Hongzhi Tang, Yaling Shen, Ping Xu
1,3-Propanediol (1,3-PD), a valuable bulk industrial material, has attracted increasing interest in recent years. A novel strain GYL isolated from soil samples could efficiently convert glycerol to 1,3-PD anaerobically. The physiological and biochemical characteristics of strain GYL were determined, indicating that strain GYL is a member of Clostridium perfringens with the neighbor-joining method of 16S rRNA gene sequences. The fermentation properties of strain GYL were also investigated systematically, which showed that the strain has a fast growth speed and high tolerance to 200g/L glycerol...
February 28, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28303245/biocompatibility-and-effectiveness-evaluation-of-a-new-hemostatic-embolization-agent-thrombin-loaded-alginate-calcium-microsphere
#5
Fengqi Xuan, Jingjing Rong, Ming Liang, Xuwen Zhang, Jingyang Sun, Lijun Zhao, Yang Li, Dan Liu, Fei Li, Xiaozeng Wang, Yaling Han
Background. Until now, there has been no ideal embolization agent for hemorrhage in interventional treatment. In this study, the thrombin was encapsulated in alginate calcium microsphere using electrostatic droplet technique to produce new embolization agent: thrombin loaded alginate calcium microspheres (TACMs). Objectives. The present work was to evaluate the biocompatibility and hemostatic efficiency of TACMs. Methods. Cell cytotoxicity, hemolysis, and superselective embolization of dog liver arteries were performed to investigate the biocompatibility of TACMs...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28301078/jerome%C3%A2-a-berson-1924-2017
#6
Robert G Bergman
Jerome A. Berson, Sterling Professor Emeritus at Yale University, passed away on January 13, 2017. Berson was a major figure in physical organic chemistry and the study of organic reaction mechanisms, and he published two outstanding books on the history of chemistry.
March 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28294965/differences-in-dietary-preferences-personality-and-mental-health-in-australian-adults-with-and-without-food-addiction
#7
Tracy Burrows, Leanne Hides, Robyn Brown, Christopher V Dayas, Frances Kay-Lambkin
Increased obesity rates, an evolving food supply and the overconsumption of energy dense foods has led to an increase in research exploring addictive eating behaviours. This study aimed to investigate food addiction in a sample of Australian adults using the revised Yale Food Addiction Survey (YFAS) 2.0 tool and how it is associated with dietary intake, personality traits and mental health issues. Australian adults were invited to complete an online survey that collected information including: demographics, dietary intake, depression, anxiety, stress and personality dimensions including impulsivity, sensation seeking, hopelessness and anxiety sensitivity...
March 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28294475/sodium-tanshinone-iia-sulfonate-prevents-hypoxic-trophoblast-induced-endothelial-cell-dysfunction-via-targeting-hmgb1-release
#8
Min Zhao, Yaling Feng, Jianping Xiao, Jie Liang, Yongxiang Yin, Daozhen Chen
Preeclampsia (PE) is a serious blood pressure disorder of pregnancy. Systemic endothelial cell dysfunction, a hallmark of PE, is previously estimated to be induced by hypoxic trophoblast high mobility group box 1 (HMGB1). In the present study, we investigated the protective effect of sodium tanshinone IIA sulfonate (STS), the soluble form of tanshinone IIA isolated from danshen, against hypoxic trophoblast HMGB1-induced human umbilical vein endothelial cell (HUVEC) dysfunction. Our results showed that HMGB1 expression and release were significantly decreased in STS-treated hypoxic JEG-3 cells...
February 16, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28289952/tic-severity-and-treatment-in-children-the-effect-of-comorbid-attention-deficit-hyperactivity-disorder-and-obsessive-compulsive-behaviors
#9
Tamara Pringsheim
While attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder have been shown to have major impacts on quality of life in individuals with Tourette syndrome, there is comparatively little data on how the presence of these comorbidities influence tic severity and treatment. 114 children (mean age 10.25 years) were extensively clinically phenotyped at a single specialty clinic. While there was no difference in Yale Global Tic Severity Scale (YGTSS) scores in children with versus without ADHD, children with obsessive compulsive behaviors had significantly higher YGTSS scores (p = 0...
March 13, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28289551/tic-exacerbation-in-adults-with-tourette-syndrome-a-case-series
#10
Sara M Schaefer, Christopher A Chow, Elan D Louis, Daphne Robakis
BACKGROUND: Tourette syndrome (TS) has been described as peaking in adolescence with subsequent regression. We report patients who were diagnosed with TS during childhood who experienced a latent period (significant reduction in or absence of tics) followed by tic re-emergence in adulthood. METHODS: We performed a retrospective chart review of outpatients over age 21 seen at the Yale neurology clinic between January 2012 and July 2016 who were diagnosed with childhood-onset tics, and who experienced a latent period of greater than 1 year followed by an exacerbation...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28289044/exploiting-social-influence-to-magnify-population-level-behaviour-change-in-maternal-and-child-health-study-protocol-for-a-randomised-controlled-trial-of-network-targeting-algorithms-in-rural-honduras
#11
Holly B Shakya, Derek Stafford, D Alex Hughes, Thomas Keegan, Rennie Negron, Jai Broome, Mark McKnight, Liza Nicoll, Jennifer Nelson, Emma Iriarte, Maria Ordonez, Edo Airoldi, James H Fowler, Nicholas A Christakis
INTRODUCTION: Despite global progress on many measures of child health, rates of neonatal mortality remain high in the developing world. Evidence suggests that substantial improvements can be achieved with simple, low-cost interventions within family and community settings, particularly those designed to change knowledge and behaviour at the community level. Using social network analysis to identify structurally influential community members and then targeting them for intervention shows promise for the implementation of sustainable community-wide behaviour change...
March 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28287993/prediction-of-adverse-events-in-patients-undergoing-major-cardiovascular-procedures
#12
Bobak Mortazavi, Nihar Desai, Jing Zhang, Andreas Coppi, Frederick Warner, Harlan Krumholz, Sahand Negahban
Electronic health records (EHR) provide opportunities to leverage vast arrays of data to help prevent adverse events, improve patient outcomes, and reduce hospital costs. This work develops a postoperative complications prediction system by extracting data from the EHR and creating features. The analytic engine then provides model accuracy, calibration, feature ranking, and personalized feature responses. This allows clinicians to interpret the likelihood of an adverse event occurring, general causes for these events, and the contributing factors for each specific patient...
March 1, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28287064/concentrated-erp-delivered-in-a-group-setting-a-replication-study
#13
Audun Havnen, Bjarne Hansen, Lars-Göran Öst, Gerd Kvale
BACKGROUND: In a previous effectiveness study (Havnen et al., 2014), 35 obsessive compulsive disorder (OCD) patients underwent Concentrated Exposure Treatment (cET), which is a newly developed group treatment format delivered over four consecutive days. AIMS: The primary aims of the present study were to evaluate the treatment results for a new sample of OCD patients receiving the cET treatment approach and to replicate the effectiveness study described in Havnen et al...
March 13, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28282525/association-between-vascular-endothelial-growth-factor-polymorphism-and-recurrent-pregnancy-loss-a-systematic-review-and-meta-analysis
#14
REVIEW
Yaling Sun, Min Chen, Benyu Mao, Xianglin Cheng, Xianping Zhang, Chuanxin Xu
PURPOSE: Some studies have reported that vascular endothelial growth factor (VEGF) genetic polymorphisms are associated with recurrent pregnancy loss (RPL), but the results are controversial. This study is aimed to quantify the strength of this association. METHODS: A systematic review of the published literature from Medline, Springer, and China National Knowledge Infra structure (CNKI) databases was conducted and investigations of VEGF genetic polymorphisms in RPL were selected...
March 2, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28280480/the-efficacy-and-tolerability-of-the-clonidine-transdermal-patch-in-the-treatment-for-children-with-tic-disorders-a-prospective-open-single-group-self-controlled-study
#15
Pan-Pan Song, Li Jiang, Xiu-Juan Li, Si-Qi Hong, Shuang-Zi Li, Yue Hu
BACKGROUND: To evaluate the efficacy and tolerability of a clonidine transdermal patch in the treatment of children with tic disorders (TD) and to establish a predictive model for patients. METHODS: Forty-one patients who met the inclusion criteria entered into 12 weeks of prospective, open, single-group, self-controlled treatment with a clonidine transdermal patch. The Yale Global Tic Severity Scale (YGTSS) was employed before therapy (baseline) and at 4, 8, and 12 weeks after therapy...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28265120/a-genome-wide-gene-by-trauma-interaction-study-of-alcohol-misuse-in-two-independent-cohorts-identifies-prkg1-as-a-risk-locus
#16
R Polimanti, J Kaufman, H Zhao, H R Kranzler, R J Ursano, R C Kessler, J Gelernter, M B Stein
Traumatic life experiences are associated with alcohol use problems, an association that is likely to be moderated by genetic predisposition. To understand these interactions, we conducted a gene-by-environment genome-wide interaction study (GEWIS) of alcohol use problems in two independent samples, the Army STARRS (STARRS, N=16 361) and the Yale-Penn (N=8084) cohorts. Because the two cohorts were assessed using different instruments, we derived separate dimensional alcohol misuse scales and applied a proxy-phenotype study design...
March 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28260897/impact-of-parental-presence-during-induction-of-anesthesia-on-anxiety-level-among-pediatric-patients-and-their-parents-a-randomized-clinical-trial
#17
Afsaneh Sadeghi, Ahmad Khaleghnejad Tabari, Alireza Mahdavi, Sara Salarian, Seyed Sajjad Razavi
INTRODUCTION: Anesthesia induction is a stressful event for children and their parents, and may have potentially harmful consequences on the patient's physiological and mental situation. Stressful anesthesia induction has psychological adverse effects that recur with repeated anesthesia, can lead to increased pediatric discomfort during the recovery period, and may even induce reactionary postoperative behavior. A randomized controlled trial was performed to assess the impact of parental presence during induction of anesthesia (PPIA) on preoperative anxiety of pediatric patients and their parents at three different times, cooperation of child with anesthesiologist at induction of anesthesia, and parental satisfaction...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28260605/gambling-disorder-dsm-5-criteria-and-symptom-severity
#18
Jon E Grant, Brian L Odlaug, Samuel R Chamberlain
INTRODUCTION: Gambling disorder (GD) is a prevalent psychiatric condition whose severity is typically defined by the number of DSM-5 criteria met out of a maximum of nine. The relationships between the levels of gambling severity, thus defined, and other measures of psychopathology and everyday functioning are clinically important. METHODS: Baseline data were collected in patients with GD, conducted from 2001 to 2016. Participants completed clinical interviews and questionnaires...
February 21, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28260577/sasha-handley-sleep-in-early-modern-england-new-haven-ct-and-london-yale-university-press-2016-pp-%C3%A2-xii%C3%A2-%C3%A2-280-%C3%A2-25-00-hardback-isbn-9780300220391
#19
https://www.readbyqxmd.com/read/28252670/divergence-of-stable-isotopes-in-tap-water-across-china
#20
Sihan Zhao, Hongchang Hu, Fuqiang Tian, Qiang Tie, Lixin Wang, Yaling Liu, Chunxiang Shi
Stable isotopes in water (e.g., δ(2)H and δ(18)O) are important indicators of hydrological and ecological patterns and processes. Tap water can reflect integrated features of regional hydrological processes and human activities. China is a large country with significant meteorological and geographical variations. This report presents the first national-scale survey of Stable Isotopes in Tap Water (SITW) across China. 780 tap water samples have been collected from 95 cities across China from December 2014 to December 2015...
March 2, 2017: Scientific Reports
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