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https://www.readbyqxmd.com/read/29232795/-clinical-study-of-testicular-fasciotomy-for-testicular-torsion
#1
Seiji Nagasawa, Akihiro Kanematsu, Yasuhiro Shinkai, Kimihiro Shimatani, Takahiko Hashimoto, Yoshikazu Togo, Toru Suzuki, Shuken Go, Michio Nojima, Shingo Yamamoto
Between November 2011 and November 2014, we performed a tunica albuginea incision with tunica vaginalis flap coverage (TAI+TVFC) on 5 out of 15 patients who underwent surgery for testicular torsion. Of those 15 patients, 7 underwent orchidopexy alone (Group A), 5 underwent TAI+TVFC (Group B), and 3 underwent an orchidectomy procedure (Group C). All were followed for 1 year and preservation of testicular volume >50% on the contralateral side in ultrasound measurements was considered as salvaged. During the follow-up examinations, no testicular atrophy was noted in Group A...
November 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29198187/unusual-presentation-of-prune-belly-syndrome-a-case-report
#2
Abayneh Girma Demisse, Ashenafi Berhanu, Temesgen Tadesse
BACKGROUND: Prune belly syndrome is a rare congenital malformation of unknown etiology, with the following triad of findings: abdominal muscle wall weakness, undescended testes, and urinary tract abnormalities. In most cases, detection of prune belly syndrome occurs during neonatal or infancy period. In this case report, we describe a 12-year-old boy from Ethiopia with the triad of findings of prune belly syndrome along with skeletal malformations. We are unaware of any previous report of prune belly syndrome in Ethiopia...
December 4, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29188379/inguinal-hernia-repair-by-bianchi-incision-in-boys-a-retrospective-study
#3
Junshan Lin, Dumiao Li, Jinwen Chen, Li Lin, Yali Xu
OBJECTIVE: Open inguinal hernia repair by Bianchi incision is a potential alternative technique for the treatment of IH. This study aims to retrospectively analyze boys with IH, who underwent open IH repair by Bianchi incision. METHODS: A total of 3300 boys (1-144 months) with IH from April 2007 to September 2015 were enrolled into this study. An open high scrotal incision (Bianchi incision) to ligate the processus proximal to the internal inguinal ring was performed in patients for IH repair...
November 29, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29182986/amelioration-of-cadmium-induced-testes-damage-in-rats-by-the-bone-marrow-mesenchymal-stem-cells
#4
Heba Allah M Elbaghdady, Maha A Alwaili, Reda S El-Demerdash
Cadmium (Cd) and its compounds are highly toxic to virtually all organ systems of the mammals. Cd-induced testicular injuries have been reported in various animal species, using different protocols. The self-renewal capacity and the ability to generate different specialized cell types make the mesenchymal stem cells (MSCs) one of the ideal choices for restoring tissue damages of various etiologies. The use of bone marrow-derived MSCs (BM-MSCs) is among the most recent strategies to repair the Cd-induced testicular damage, but empirical studies in this regard are largely missing...
November 25, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29120657/-anabolic-steroid-induced-hypogonadism-in-men-overview-and-case-report
#5
Luboslav Stárka, Michaela Dušková, Lucie Kolátorová, Oldřich Lapčík
An important potential consequence of the anabolic steroid misuse is hypogonadotropic hypogonadism due to the inhibition of pituitary secretion of gonadotropins. By the symptoms as testicular atrophy, spermatogenic and fertility disturbances or dysfunction in sexual life, the anabolic steroids induced hypogonadism (ASIH) could be differentiated from organic hypogonadotropic hypogonadism only with difficulty unless the misuse is reported by the user. When diagnosed, the crucial step in the therapy is the stop of anabolic use...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29093257/-primary-mediastinal-choriocarcinoma-a-case-report-and-literature-review
#6
Man Luo, Hong Peng, Min Song, Qianhui Zhou, Yaomei Long, Ping Chen
Primary mediastinal choriocarcinoma in male is not a very common disease, with nonspecific clinical manifestations. Gynecomastia and testicular atrophy are present in some cases. The levels of serum human chorionic gonadotropin are often significantly increased. Giant lump in the mediastinum and bilateral lungs multiple metastases can be seen on the computed tomography for lung. The diagnosis for it depends on pathological biopsy. Current treatment method is a comprehensive, consisting of chemotherapy, radiotherapy and surgery...
October 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29083263/fifteen-years-experience-with-laparoscopic-inguinal-hernia-repair-in-infants-and-children
#7
Rafik Shalaby, Mohamed Abd Alrazek, Adham Elsaied, Ahmad Helal, Mohamad Mahfouz, Maged Ismail, Abdelmoniem Shams, Mohamad Magid
BACKGROUND: Laparoscopic inguinal hernia repair (LIHR) is gaining popularity with more studies validating its feasibility, safety, and efficacy. The aim of this work is to review our experience with LIHR in infants and children during the past 15 years, and present and evaluate our innovations of laparoscopic techniques. PATIENTS AND METHODS: A retrospective study of 1284 patients with congenital inguinal hernia (CIH) subjected to different techniques of LIHR from October 2000 to October 2015...
October 30, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29081016/a-review-of-imaging-modalities-used-in-the-diagnosis-and-management-of-scrotal-trauma
#8
REVIEW
Alexis Wang, Ian Stormont, M Minhaj Siddiqui
Genitourinary tract injuries account for 3 to 10% of trauma patients, and scrotal trauma is particularly prevalent in males 10 to 30 years of age. Prompt diagnosis and timely surgical intervention are essential to prevent future complications of infertility, delayed orchiectomy, infection, and testicular atrophy. While clinical examination provides valuable information, it may be inconclusive due to soft tissue swelling and difficult to perform due to testicular pain with palpation. Conversely, testicular rupture does not always present with pain or tenderness...
October 28, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/29019559/comparison-between-inguinal-herniotomies-with-and-without-incising-external-oblique-aponeurosis-a-randomized-clinical-trial
#9
Shahnam Askarpour, Mehran Peyvasteh, Shaghayegh Sherafatmand
BACKGROUND: Inguinal herniotomy is the most common surgery performed by pediatric surgeons. AIM: To compare the results and complications between two conventional methods of pediatric inguinal herniotomy with and without incising external oblique aponeurosis in terms of recurrence of hernia and other complications. METHODS: This one blinded clinical trial study was conducted on 800 patients with indirect inguinal hernia. Inclusion criterion was children with inguinal hernia...
July 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28992606/apoptotic-mechanism-behind-the-testicular-atrophy-in-photorefractory-and-scotosensitive-quail-involvement-of-gnih-induced-p-53-dependent-bax-caspase-3-mediated-pathway
#10
Somanshu Banerjee, Chandra Mohini Chaturvedi
In most of the avian species, daylength or photoperiod is the main environmental factor regulating reproduction. During their annual gonadal cycle, birds once sensitive to short or long day effect develop refractoriness to the same daylength and gonad develop or regress accordingly. The present study investigated the effects of photoperiodic alterations on apoptosis mediated testicular responses of photosensitive/photorefractory and scotosensitive/scotorefractory quail, Coturnix coturnix japonica. Testicular apoptosis in the quail of different photoperiodic conditions was assessed by monitoring the alterations in the local testicular expression of GnRH-I, GnIH, pro-apoptotic proteins (p53 and Bax), inactive caspase (pro-Caspase-3), executioner active-Caspase-3 and inactive/uncleaved PARP-1 (DNA repair enzyme) and TUNEL analysis...
September 29, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28991271/diabetes-mellitus-and-optic-atrophy-study-of-the-wolfram-syndrome
#11
Bernardette Rivas-Gómez, Alfredo Adolfo Reza-Albarrán
Background: Wolfram syndrome (WS), also known by the acronym DIDMOAD, is a rare and progresive hereditary disease of autosomal recessive inheritance which minimum ascertainment diagnostic criteria are the occurrence together of diabetes mellitus and optic atrophy before 15 years of age. Objective: To describe the clinical, biochemical and molecular profile of WS in a tertiary care hospital in Mexico. Materials and Methods: We reviewed patients records who fulfill the minimum ascertainment diagnostic criteria of WS presenting between January 1987 and May 2015 in a tertiary care hospital in Mexico...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28953100/a-systematic-review-of-testicle-survival-time-after-a-torsion-event
#12
Larry Bruce Mellick, James E Sinex, Robert W Gibson, Kim Mears
BACKGROUND: The time window for possible salvage and survival of a torsed testicle is commonly thought to be 6 to 8 hours. However, survival of torsed testicles with or without subsequent atrophy is known to occur outside that critical time window. In this article, we performed a systematic review of the English literature to provide a more accurate understanding of reported time frames of testicle survival after a torsion event. OBJECTIVES: The primary research question was to determine the relationship between time to treatment and the rate of survival for testicles of male patients presenting with testicular torsion (TT)...
September 25, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28943032/formaldehyde-inhibits-sexual-behavior-and-expression-of-steroidogenic-enzymes-in-the-testes-of-mice
#13
Zhi-Jun Zang, You-Qiang Fang, Su-Yun Ji, Yong Gao, Yuan-Qiang Zhu, Ting-Ting Xia, Mei-Hua Jiang, Ya-Nan Zhang
BACKGROUND: Formaldehyde, a ubiquitous environmental pollutant, is used extensively and has been proved to impair male reproduction in mammals. However, no trials have explored whether formaldehyde affects sexual function. AIM: To evaluate the effect of long-term formaldehyde exposure on sexual behavior and to investigate the potential mechanism. METHODS: Forty C57BL/6 male mice were randomly allocated to four equally sized groups. Mice were exposed to formaldehyde at a dose of 0 (control), 0...
September 21, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28923598/testicular-atrophy-and-reproductive-quiescence-in-photorefractory-and-scotosensitive-quail-involvement-of-hypothalamic-deep-brain-photoreceptors-and-gnrh-gnih-system
#14
Somanshu Banerjee, Chandra Mohini Chaturvedi
Birds time their daily and seasonal activities in synchronization with circadian and annual periodicities in the environment, which is mainly provided by changes in photoperiod/day length conditions. Photoperiod appears to act at the level of eye, pineal and encephalic/deep brain photoperception and thus entrain the hypothalamic clock as well as reproductive circuitry in different avian species. In this article our focus of study is to elucidate out the underlying molecular mechanism of modulation of the hypothalamic reproductive circuitry following the photoperception through the hypothalamic photoreceptor cells and the subsequent alteration in the reproductive responses in quail, kept under different simulated photoperiodic conditions...
October 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28894178/effect-of-prenatal-dinch-plasticizer-exposure-on-rat-offspring-testicular-function-and-metabolism
#15
Enrico Campioli, Sunghoon Lee, Matthew Lau, Lucas Marques, Vassilios Papadopoulos
In 2002, the plasticizer 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) was introduced in the European market as a substitute for endocrine-disrupting phthalates. We found that in utero exposure of rats to DINCH from gestational day 14 until parturition affected reproductive organ physiology and reduced circulating testosterone levels at post-natal day 60, indicating a long-term effect on Leydig cells of the testis. Metabolically, animals exhibited randomly increased serum glucose concentrations not associated with impaired glucose utilization...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893603/human-polyclonal-antibodies-produced-in-transchromosomal-cattle-prevent-lethal-zika-virus-infection-and-testicular-atrophy-in-mice
#16
Derek R Stein, Joseph W Golden, Bryan D Griffin, Bryce M Warner, Charlene Ranadheera, Leanne Scharikow, Angela Sloan, Kathy L Frost, Darwyn Kobasa, Stephanie A Booth, Matthew Josleyn, John Ballantyne, Eddie Sullivan, Jin-An Jiao, Hua Wu, Zhongde Wang, Jay W Hooper, David Safronetz
Zika virus (ZIKV) is rapidly spreading throughout the Americas and is associated with significant fetal complications, most notably microcephaly. Treatment with polyclonal antibodies for pregnant women at risk of ZIKV-related complications could be a safe alternative to vaccination. We found that large quantities of human polyclonal antibodies could be rapidly produced in transchromosomal bovines (TcB) and successfully used to protect mice from lethal infection. Additionally, antibody treatment eliminated ZIKV induced tissue damage in immunologically privileged sites such as the brain and testes and protected against testicular atrophy...
September 8, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28865467/beneficial-effects-of-curcumin-nano-emulsion-on-spermatogenesis-and-reproductive-performance-in-male-rats-under-protein-deficient-diet-model-enhancement-of-sperm-motility-conservancy-of-testicular-tissue-integrity-cell-energy-and-seminal-plasma-amino-acids
#17
Omar A H Ahmed-Farid, Maha Nasr, Rania F Ahmed, Rofanda M Bakeer
BACKGROUND: Malnutrition resulting from protein and calorie deficiency continues to be a major concern worldwide especially in developing countries. Specific deficiencies in the protein intake can adversely influence reproductive performance. The present study aimed to evaluate the effects of curcumin and curcumin nano-emulsion on protein deficient diet (PDD)-induced testicular atrophy, troubled spermatogenesis and decreased reproductive performance in male rats. METHODS: Juvenile rats were fed the protein deficient diet (PDD) for 75 days...
September 2, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28834365/spontaneous-testicular-atrophy-occurs-despite-normal-spermatogonial-proliferation-in-a-tp53-knockout-rat
#18
M S Dai, S J Hall, M M Vantangoli Policelli, K Boekelheide, D J Spade
The tumor suppressor protein p53 (TP53) has many functions in cell cycle regulation, apoptosis, and DNA damage repair and is also involved in spermatogenesis in the mouse. To evaluate the role of p53 in spermatogenesis in the rat, we characterized testis biology in adult males of a novel p53 knockout rat (SD-Tp53(tm1sage) ). p53 knockout rats exhibited variable levels of testicular atrophy, including significantly decreased testis weights, atrophic seminiferous tubules, decreased seminiferous tubule diameter, and elevated spermatocyte TUNEL labeling rates, indicating a dysfunction in spermatogenesis...
November 2017: Andrology
https://www.readbyqxmd.com/read/28759947/paediatric-surgical-services-in-remote-northern-australia-an-integrated-model-of-care
#19
Liam Quinn, David Read
BACKGROUND: Surgical services for children in the Northern Territory of Australia are routinely performed by general surgeons with specific paediatric training, supported by paediatric surgeons. In Australasia, indications for appropriate transfer of elective routine surgery in children to tertiary paediatric surgical centres have been contentious. To transfer all elective paediatric cases from rural locations would have significant social and financial consequences for families and the health system...
July 31, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28710293/probing-gata-factor-function-in-mouse-leydig-cells-via-testicular-injection-of-adenoviral-vectors
#20
Gervette M Penny, Rebecca B Cochran, Marjut Pihlajoki, Antti Kyrönlahti, Anja Schrade, Merja Häkkinen, Jorma Toppari, Markku Heikinheimo, David B Wilson
Testicular Leydig cells produce androgens essential for proper male reproductive development and fertility. Here, we describe a new Leydig cell ablation model based on Cre/Lox recombination of mouse Gata4 and Gata6, two genes implicated in the transcriptional regulation of steroidogenesis. The testicular interstitium of adult Gata4(flox/flox) ; Gata6(flox/flox) mice was injected with adenoviral vectors encoding Cre + GFP (Ad-Cre-IRES-GFP) or GFP alone (Ad-GFP). The vectors efficiently and selectively transduced Leydig cells, as evidenced by GFP reporter expression...
October 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
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