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https://www.readbyqxmd.com/read/28215837/antegrade-sclerotherapy-in-adolescent-varicocele-patients
#1
D J B Keene, R M Cervellione
INTRODUCTION: In the 1970s, Tauber described the antegrade sclerotherapy technique to treat varicoceles, and reported a 10% recurrence rate. The present study aimed to evaluate paediatric success rates and the effect of modifications to the surgical technique. METHODS: A prospective study was performed of all adolescent patients undergoing antegrade sclerotherapy surgery. Each patient had an idiopathic varicocele with spontaneous venous reflux on Doppler examination, and underwent cannulation of a pampiniform plexus vein via a scrotal incision under general anaesthetic...
January 29, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28192182/male-reproductive-toxicity-of-crvi-in-utero-exposure-to-crvi-at-the-critical-window-of-testis-differentiation-represses-the-expression-of-sertoli-cell-tight-junction-proteins-and-hormone-receptors-in-adult-f1-progeny-rats
#2
Kathiresh M Kumar, Mariajoseph Michael Aruldhas, Sheerin L Banu, Balaji Sadasivam, Ganapathy Vengatesh, Karthik M Ganesh, Shobana Navaneethabalakrishnan, Ajith Kumar Navin, Felicia Mary Michael, Sankar Venkatachalam, Jone A Stanley, Ilangovan Ramachandran, Sakhila K Banu, Mohammad Abdulkader Akbarsha
The effect of gestational exposure to CrVI (occupational/environmental pollutant and target to Sertoli cells(SC)) was tested in a rat model during the testicular differentiation from the bipotential gonad may interrupt spermatogenesis by disrupting SC tight junctions(TJ) and it's proteins and hormone receptors. Pregnant Wistar rats were exposed to 50/100/200ppm CrVI through drinking water during embryonic days 9-14. On Postnatal day 120, testes were subjected to ion exchange chromatographic analysis revealed increased level of CrIII in SCs and germ cells, serum and testicular interstitial fluid(TIF)...
February 9, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28190922/histopathological-background-data-of-the-systemic-organs-of-clawn-miniature-swine-with-coronary-artery-stent-implantation
#3
Atsushi Isobe, Masako Tasaki, Tomoki Inoue, Hisako Terao, Junko Souba, Kasuke Nagano, Hitomi Hagiwara
The aim of this study was to identify potential changes that could occur during histological evaluations of CLAWN miniature swine, with potential consequences for subsequent experiments. The systemic organs from male and female CLAWN miniature swine (16.3-42.3 months old) that had been used in long-term studies of coronary stent implantation were examined histologically. Commonly observed histopathological findings were testicular/epididymal atrophy, cyst-like follicles in the ovaries, hemosiderin deposition in the spleen, lipofuscin deposition in the proximal tubular epithelia and presence of eosinophilic globules in the Bowman's space and the lumen of the proximal tubules in the kidneys, and cellular infiltration in several organs, including the eyelids, respiratory organs, and digestive tract...
January 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28176510/methylene-blue-dye-for-identification-of-processus-vaginalis-during-hydrocele-repair-experience-in-a-teaching-hospital
#4
Salvatore Arena, Tiziana Russo, Pietro Impellizzeri, Pietro Antonuccio, Patrizia Perrone, Carmelo Romeo
BACKGROUND: To investigate the use of methylene blue in perioperative identification of the patent processus vaginalis in a group of boys presenting with congenital or recurrent hydrocele where surgery was performed by junior surgeons in training. METHODS: We retrospectively reviewed the notes of 22 boys with hydrocele, of which two recurrences, who were operated on via a standard inguinal approach, by trainees. Methylene blue 0.3-0.5 ml was injected into the hydrocele fluid through the scrotal wall...
February 7, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28160395/a-novel-disorder-of-sex-development-characterized-by-progressive-regression-of-testicular-function-and-cystic-leukoencephalopathy
#5
Massimiliano Rossi, Alexandre Vasiljevic, Audrey Labalme, Frédérique Dijoud, Delphine Mallet-Motak, Carmen Adina Petcu, Renaud Touraine, Christine Vianey-Saban, Laurent Guibaud, Patrick Edery, Damien Sanlaville, Yves Morel
We report a novel syndromic disorder of sex development observed in three male siblings, presenting with the association of micropenis without hypospadias, cryptorchidism, very low level of antimüllerian hormone in the neonatal period, and no persistent müllerian duct structures, suggesting a progressive regression of testicular function. The patients described here showed a striking neurological involvement including bilateral periventricular cysts observed in the anterior part of the frontal horns prenatally and increasing in size and number over time, associated with infra and supratentorial parenchymal atrophy, dilated ventricular system, corpus callosum hypoplasia, severe intellectual disability, and epilepsy...
February 4, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28158260/effects-of-calorie-restriction-on-the-lifespan-and-healthspan-of-polg-mitochondrial-mutator-mice
#6
Shinichi Someya, Gregory C Kujoth, Mi-Jung Kim, Timothy A Hacker, Marc Vermulst, Richard Weindruch, Tomas A Prolla
Mitochondrial DNA (mtDNA) mutations are thought to have a causative role in age-related pathologies. We have shown previously that mitochondrial mutator mice (PolgD257A/D257A), harboring a proofreading-deficient version of the mtDNA polymerase gamma (POLG), accumulate mtDNA mutations in multiple tissues and display several features of accelerated aging. Calorie restriction (CR) is known to delay the onset of age-related diseases and to extend the lifespan of a variety of species, including rodents. In the current study we investigated the effects of CR on the lifespan and healthspan of mitochondrial mutator mice...
2017: PloS One
https://www.readbyqxmd.com/read/28117235/-experience-of-the-single-scrotal-approach-for-recurrent-undescended-testis-after-primary-orchiopexy-or-inguinal-surgery
#7
J-B Marret, P Ravasse, K Guleryuz, A Haffreingue, J Rod
OBJECTIVE: To report our experience of the unique scrotal incision for the redo cases of orchiopexy after previous inguinal surgery or orchiopexy for undescended testis with a special attention regarding the place of the single scrotal approach. PATIENTS AND METHODS: Thirty-six patients operated between January 2003 and September 2015 in our surgical unit for secondary orchiopexy after previous inguinal surgery or orchiopexy for undescended testis (UDT) were included in a retrospective study...
February 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28105089/laparoscopic-surgery-in-the-treatment-of-incarcerated-indirect-inguinal-hernia-in-children
#8
Yiyu Yin, Hongwei Zhang, Xiang Zhang, Fang Sun, Huaxin Zou, Hui Cao, Cheng Wen
We aimed to explore the feasibility and the safety of the laparoscopic surgery for incarcerated indirect inguinal hernia (IIH) in children. From January 2012 to December 2014, 64 children were enrolled into this study. All 64 patients received laparoscopic surgery and we reviewed their perioperative and postoperative follow-up studies. In addition, we enrolled 60 cases of children who received traditional surgery of IIH administered through minimally invasive surgery as the control group. Results from the present study showed that the mean operation time for the laparoscopic group was 41...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28073203/testicular-sparing-surgery-in-small-testis-masses-a-multinstitutional-experience
#9
Andrea B Galosi, Paola Fulvi, Andrea Fabiani, Lucilla Servi, Alessandra Filosa, Luca Leone, Angelo Marronaro, Enrico Caraceni, Rodolfo Montironi
INTRODUCTION: The incidence of benign testicular tumors is increasing in particular in small lesion incidentally found at scrotal ultrasonography. Primary aim of this study was to perform radical surgery in malignant tumor. Secondary aim was to verify the efficacy of the diagnostic-therapeutic pathway recently adopted in management of small masses with testis sparing surgery in benign lesions. MATERIALS AND METHODS: In this multicenter study, we reviewed all patients with single testis lesion less than 15 mm at ultrasound as main diameter...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28063682/recurrence-rates-in-pediatric-patients-undergoing-microsurgical-subinguinal-varicocelectomy-with-and-without-testicular-delivery
#10
Chang Il Choi, Kyung Chae Park, Tae Ho Lee, Young Kwon Hong
BACKGROUND/PURPOSE: The purpose of the study was to determine if testicular delivery during microsurgical subinguinal varicocelectomy (MSV) reduces varicocele recurrence rates in pediatric patients. Testicular delivery during MSV enables ligation of the gubernacular veins, which is thought to reduce the likelihood of varicocele recurrence. However, recent studies have suggested that testicular delivery during MSV does not offer any beneficial effect and, therefore, may be optional or unnecessary...
December 24, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28032143/an-evidence-based-review-of-the-genotoxic-and-reproductive-effects-of-sulfur-mustard
#11
REVIEW
Fazlullah Khan, Kamal Niaz, Fatima Ismail Hassan, Mohammad Abdollahi
Sulfur mustard (SM) is a chemical warfare agent which is cytotoxic in nature, and at the molecular level, SM acts as DNA alkylating agent leading to genotoxic and reproductive effects. Mostly, the exposed areas of the body are the main targets for SM; however, it also adversely affects various tissues of the body and ultimately exhibits long-term complications including genotoxic and reproductive effects, even in the next generations. The effect of SM on reproductive system is the reason behind male infertility...
December 28, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/28025693/laparoscopic-versus-open-inguinal-hernia-repair-in-children-%C3%A2-3-a-randomized-controlled-trial
#12
Colin D Gause, Maria G Sacco Casamassima, Jingyan Yang, Grace Hsiung, Daniel Rhee, Jose H Salazar, Dominic Papandria, Howard I Pryor, Dylan Stewart, Jeffrey Lukish, Paul Colombani, Nicole M Chandler, Emilie Johnson, Fizan Abdullah
PURPOSE: Laparoscopy is being increasingly applied to pediatric inguinal hernia repair. In younger children, however, open repair remains preferred due to concerns related to anesthesia and technical challenges. We sought to assess outcomes after laparoscopic and open inguinal hernia repair in children less than or equal to 3 years. METHODS: A prospective, single-blind, parallel group randomized controlled trial was conducted at three clinical sites. Children ≤3 years of age with reducible unilateral or bilateral inguinal hernias were randomized to laparoscopic herniorrhaphy (LH) or open herniorrhaphy (OH)...
December 26, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27979262/effects-and-detection-of-nandrosol-and-ractopamine-administration-in-veal-calves
#13
Sara Divari, Enrica Berio, Paola Pregel, Alessandra Sereno, Luca Chiesa, Radmila Pavlovic, Sara Panseri, Toine F H Bovee, Bartolomeo Biolatti, Francesca T Cannizzo
The present study describes different effects of the selective androgen receptor modulator (SARM) nandrolone phenylpropionate (Nandrosol) and the β-agonist ractopamine administration in veal calves, and it investigates different strategies applied to trace these molecules. Morphological changes of gonads and accessory glands attributed to androgen effects, such as testicular atrophy, seminiferous tubule diameter reduction and hyperplasia of prostate epithelium, were detected, although SARMs are not described to cause these lesions...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27928778/previously-unreported-biallelic-mutation-in-dnajc19-are-sensorineural-hearing-loss-and-basal-ganglia-lesions-additional-features-of-dilated-cardiomyopathy-and-ataxia-dcma-syndrome
#14
Sema Kalkan Ucar, Johannes A Mayr, René G Feichtinger, Ebru Canda, Mahmut Çoker, Saskia B Wortmann
BACKGROUND: Dilated cardiomyopathy (DCM), non-progressive cerebellar ataxia (A), testicular dysgenesis, growth failure, and 3-methylglutaconic aciduria are the hallmarks of DNAJC19 defect (or DCMA syndrome) due to biallelic mutations in DNAJC19. To date DCMA syndrome has been reported in 19 patients from Canada and in two Finnish siblings. The underlying pathomechanism is unknown; however, DNAJC19 is presumed to be involved in mitochondrial membrane related processes (e.g., protein import and cardiolipin remodeling)...
December 8, 2016: JIMD Reports
https://www.readbyqxmd.com/read/27921092/testicular-microlithiasis-patient-compliance-in-a-two-year-follow-up-program
#15
M R Pedersen, P J S Osther, F B Soerensen, S R Rafaelsen
Introduction: We present a retrospective 2-year follow-up cohort of 103 men with testicular microlithiasis (TML) and discuss patient compliance and the value of surveillance. Methods: A retrospective analysis of patients examined with scrotal ultrasonography (US) in the period from 2008 through 2010 was performed. A total of 103 men with TML were diagnosed and offered US follow-up every 6 months for 2 years. They were retrospectively analyzed regarding demographics and follow-up details, including the development of any kind of malignancy until March 2015, using the Danish Electronic Pathology Registry...
November 2016: Ultrasound International Open
https://www.readbyqxmd.com/read/27904914/testicular-infarction-in-a-patient-with-spinal-cord-injury-with-epididymitis-a-case-report
#16
Po-Cheng Hsu, William J Huang, Shih-Fong Huang
: O-bjective: To describe a case of epididymitis-related testicular infarction in a patient with spinal cord injury. CASE REPORT: A 22-year-old man with a traumatic spinal cord injury (American Spinal Injury Association Impairment Scale A; neurological level, C4) developed epididymitis during hospitalization. He presented with spiking fever, autonomic dysreflexia, and increased spasticity. Physical examination revealed a rapidly progressive, firm swelling of the right hemiscrotum; however, the patient had no subjective complaint of pain owing to a loss of sensation...
January 19, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27872163/role-of-autophagy-in-cadmium-induced-testicular-injury
#17
Y-J Wang, J Yan, F Yin, L Li, Y-G Qin, C-Y Meng, R-F Lu, L Guo
The testis is sensitive to cadmium, but studies investigating cadmium-induced testicular injury have not yet clearly revealed the underlying mechanisms. This study aimed to investigate the injurious effects of cadmium on rat testes and the role that autophagy plays in this process. Wistar rats were randomly divided into four groups and intraperitoneally injected with 0.2 (low), 0.4 (middle), and 0.8 mg/kg·body weight (high) cadmium chloride for 5 weeks, while the control rats were injected with equal volume of saline...
November 21, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27867845/current-management-of-non-palpable-testes-a-literature-review-and-clinical-results
#18
REVIEW
Ximena Sepúlveda, Pedro-José López Egaña
Cryptorchidism is a common pathology that occurs in 3% in full term newborns, and it decreases to 0.8-1.2% at 1 year of age. Nearly a 20% of undescended testes are non-palpable. Various surgical treatments have been described, but its management is still controversial. A literature review was made of non-palpable testes, analysing diagnostic tools, treatment and its results. Additionally we reviewed non-palpable testes cases treated in our centre in the last 20 years. Different techniques are described for the management of non-palpable testes; with or without section of the spermatic vessels and/or in 1 or 2 stages...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27845220/staged-fowler-stephens-and-single-stage-laparoscopic-orchiopexy-for-intra-abdominal-testes-is-there-a-difference-a-single-institution-experience
#19
Alireza Alam, Joan C Delto, Ruben Blachman-Braun, George Wayne, Angela G Mittal, Miguel Castellan, Kristin Kozakowski, Andrew Labbie, Rafael Gosalbez
OBJECTIVE: To compare single-stage laparoscopic orchiopexy (SSLO) and staged Fowler-Stephens (SFS) procedures in the management of intra-abdominal undescended testes, and to analyze postoperative atrophy and malpositioning as end points. MATERIALS AND METHODS: A retrospective chart review identified laparoscopic orchiopexy patients with intra-abdominal testes between November 2006 and November 2014. Of 167 patients who had laparoscopic orchiopexy, 73 (85 testes) were identified as having laparoscopic orchiopexy...
November 11, 2016: Urology
https://www.readbyqxmd.com/read/27819175/early-versus-late-inguinal-hernia-repair-in-extremely-low-birth-weight-infants
#20
Rajesh Pandey, Joleen Dako, Sarah Venus, Deepak Kumar, Maroun Mhanna
OBJECTIVE: Compare outcomes of Extremely Low Birth Weight (ELBW) Infants following early (before discharge) versus late (after discharge) inguinal hernia (IH) repair. STUDY DESIGN: In a retrospective study of ELBW infants with IH, data was abstracted for clinical characteristics, IH and related outcomes. RESULT: Of the 39/252 (15.4%) ELBW infants who developed IH, those with early (59%) versus late (41%) repair were comparable in birth weight (753±158 vs...
November 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
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