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UBE2C

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https://www.readbyqxmd.com/read/29685151/digital-gene-expression-profiling-analysis-and-its-application-in-the-identification-of-genes-associated-with-improved-response-to-neoadjuvant-chemotherapy-in-breast-cancer
#1
Xiaozhen Liu, Gan Jin, Jiacheng Qian, Hongjian Yang, Hongchao Tang, Xuli Meng, Yongfeng Li
BACKGROUND: This study aimed to screen sensitive biomarkers for the efficacy evaluation of neoadjuvant chemotherapy in breast cancer. METHODS: In this study, Illumina digital gene expression sequencing technology was applied and differentially expressed genes (DEGs) between patients presenting pathological complete response (pCR) and non-pathological complete response (NpCR) were identified. Further, gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were then performed...
April 23, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29630110/overexpression-of-ube2c-correlates-with-poor-prognosis-in-gastric-cancer-patients
#2
H-Q Zhang, G Zhao, B Ke, G Ma, G-L Liu, H Liang, L-R Liu, X-S Hao
OBJECTIVE: The ubiquitin-conjugating enzyme E2C (UBE2C) has been known as a crucial factor upregulated in various tumors. The functions of UBE2C is mainly involved in the pathway protein ubiquitination. This study investigates the expression of UBE2C in gastric cancers and its correlation with overall survival rate. MATERIALS AND METHODS: Real-time PCR (RT-PCR) and Western blotting were performed to determine the expression of UBE2C in gastric cancer samples and adjacent normal tissues...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29596365/ube2c-is-a-transcriptional-target-of-the-cell-cycle-regulator-foxm1
#3
Pedro Nicolau-Neto, Antonio Palumbo, Marco De Martino, Francesco Esposito, Tatiana de Almeida Simão, Alfredo Fusco, Luiz Eurico Nasciutti, Nathalia Meireles Da Costa, Luis Felipe Ribeiro Pinto
FOXM1 (forkhead box protein M1) is a transcription factor that participates in all stages of tumor development, mainly through the control of cell cycle and proliferation, regulating the expression of genes involved in G1/S and G2/M transition and M phase progression. The ubiquitin conjugating enzyme E2 (UBE2C) is a member of the anaphase promoting complex/cyclosome, promoting the degradation of several target proteins along cell cycle progression, during metaphase/anaphase transition. FOXM1 and UBE2C have been found overexpressed in a wide range of different solid tumors...
March 29, 2018: Genes
https://www.readbyqxmd.com/read/29576589/contributions-of-ube2c-and-ube2s-to-meiotic-progression-of-porcine-oocytes
#4
Yoshie A Fujioka, Asuka Onuma, Wataru Fujii, Koji Sugiura, Kunihiko Naito
Vertebrate oocytes arrested at the first meiotic prophase must proceed to the second meiotic metaphase (MII) before fertilization. This meiotic process requires the precise control of protein degradation. Part of the protein degradation in oocytes is controlled by members of the ubiquitin-conjugating enzyme family, UBE2C and UBE2S, which are known to participate in mono-ubiquitination and poly-ubiquitination, respectively. Although UBE2 enzymes have been well studied in mitosis, their contribution to mammalian oocyte meiosis is relatively unknown and has been studied only in mice...
March 23, 2018: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29575713/functional-transcriptomic-annotation-and-protein-protein-interaction-analysis-identify-ezh2-and-ube2c-as-key-upregulated-proteins-in-ovarian-cancer
#5
Sandra Martínez-Canales, Miguel López de Rodas, Miriam Nuncia-Cantarero, Raquel Páez, Eitan Amir, Balázs Győrffy, Atanasio Pandiella, Eva María Galán-Moya, Alberto Ocaña
Although early stage ovarian cancer is in most cases a curable disease, some patients relapse even with appropriate adjuvant treatment. Therefore, the identification of patient and tumor characteristics to better stratify risk and guide rational drug development is desirable. Using transcriptomic functional annotation followed by protein-protein interacting (PPI) network analyses, we identified functions that were upregulated and associated with detrimental outcome in patients with early stage ovarian cancer...
March 25, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29483831/ten-hub-genes-associated-with-progression-and-prognosis-of-pancreatic-carcinoma-identified-by-co-expression-analysis
#6
Zhou Zhou, Yian Cheng, Yinan Jiang, Shi Liu, Meng Zhang, Jing Liu, Qiu Zhao
Since the five-year survival rate is less than 5%, pancreatic ductal adenocarcinoma (PDAC) remains the 4th cause of cancer-related death. Although PDAC has been repeatedly researched in recent years, it is still predicted to be the second leading cause of cancer death by year 2030. In our study, the differentially expressed genes in dataset GSE62452 were used to construct a co-expression network by WGCNA. The yellow module related to grade of PDAC was screened. Combined with co-expression network and PPI network, 36 candidates were screened...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29354491/opportunities-of-next-generation-sequencing-in-non-muscle-invasive-bladder-cancer-outcome-prediction
#7
REVIEW
Karl H Pang, Francesco Esperto, Aidan P Noon
Bladder cancer (BC) is a common disease in both sexes and majority of cases present as non-muscle invasive BC (NMIBC). The percentage of NMIBC progressing to muscle invasive BC (MIBC) varies between 25% and 75% and currently there are no reliable biomarkers that may predict the outcome of high-risk (HR) NMIBC. Whilst The Cancer Genome Atlas (TCGA) project has identified genetic alteration in MIBC using next-generation sequencing (NGS), genetic data in HR-NMIBC outcome prediction using this new technology are limited...
December 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29303411/ube2c-promotes-rectal-carcinoma-via-mir-381
#8
Yan Zhang, Suli Tian, Xiaodong Li, Yanchao Ji, Zhongcheng Wang, Chang Liu
We aimed to characterize the expression pattern of UBE2C in rectal carcinoma and elucidate its fundamental involvement in rectal carcinoma biology. The relative expression of UBE2C in rectal carcinoma was determined by immunoblotting and QPCR. The cell viability was measured using CCK-8 assay. The anchorage-independent growth was evaluated with soft agar assay. Cell apoptosis was detected by Annexin V-PI staining. Invasion capacity was determined by transwell chamber. Tumor growth was monitored in xenograft mice model...
March 4, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29214214/molecular-changes-in-premenopausal-oestrogen-receptor-positive-primary-breast-cancer-in-vietnamese-women-after-oophorectomy
#9
Ben P Haynes, Ophira Ginsburg, Qiong Gao, Elizabeth Folkerd, Maria Afentakis, Le Hong Quang, Pham Thi Han, Pham Hong Khoa, Nguyen Van Dinh, Ta Van To, Mark Clemons, Ian E Smith, Mitch Dowsett
For premenopausal women with primary ER + breast cancer, oophorectomy (OvX) is an evidence-based cost-effective option and is standard treatment in many countries. However, there is virtually no data describing the effects of OvX on breast tumour biology. We therefore, characterised the endocrine and genome-wide transcriptional impact of OvX in 56 premenopausal women with ER + breast cancer for 2 weeks prior to mastectomy. Plasma estradiol concentrations decreased from 406 ± 41 to 20.7 ± 2...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29159069/co-expression-network-analysis-identified-six-hub-genes-in-association-with-progression-and-prognosis-in-human-clear-cell-renal-cell-carcinoma-ccrcc
#10
Lushun Yuan, Liang Chen, Kaiyu Qian, Guofeng Qian, Chin-Lee Wu, Xinghuan Wang, Yu Xiao
Human clear cell renal cell carcinoma (ccRCC) is one of the most common types of malignant adult kidney tumors. We constructed a weighted gene co-expression network to identify gene modules associated with clinical features of ccRCC ( n  = 97). Six hub genes ( CCNB2 , CDC20 , CEP55 , KIF20A , TOP2A and UBE2C ) were identified in both co-expression and protein-protein interaction (PPI) networks, which were highly correlated with pathologic stage. The significance of expression of the hub genes in ccRCC was ranked top 4 among all cancers and correlated with poor prognosis...
December 2017: Genomics Data
https://www.readbyqxmd.com/read/29021715/the-clinicopathological-significance-of-ube2c-in-breast-cancer-a-study-based-on-immunohistochemistry-microarray-and-rna-sequencing-data
#11
Chao-Hua Mo, Li Gao, Xiao-Fei Zhu, Kang-Lai Wei, Jing-Jing Zeng, Gang Chen, Zhen-Bo Feng
BACKGROUND: Ubiquitin-conjugating enzyme E2C (UBE2C) has been previously reported to correlate with the malignant progression of various human cancers, however, the exact molecular function of UBE2C in breast carcinoma (BRCA) remained elusive. We aimed to investigate UBE2C expression in BRCA and its clinical significance. METHODS: The expression of UBE2C in 209 BRCA tissue samples and 53 adjacent normal tissue samples was detected using immunohistochemistry. The clinical role of UBE2C was analyzed...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28975155/genome-wide-scan-in-hispanics-highlights-candidate-loci-for-brain-white-matter-hyperintensities
#12
Ashley Beecham, Chuanhui Dong, Clinton B Wright, Nicole Dueker, Adam M Brickman, Liyong Wang, Charles DeCarli, Susan H Blanton, Tatjana Rundek, Richard Mayeux, Ralph L Sacco
OBJECTIVE: To investigate genetic variants influencing white matter hyperintensities (WMHs) in the understudied Hispanic population. METHODS: Using 6.8 million single nucleotide polymorphisms (SNPs), we conducted a genome-wide association study (GWAS) to identify SNPs associated with WMH volume (WMHV) in 922 Hispanics who underwent brain MRI as a cross-section of 2 community-based cohorts in the Northern Manhattan Study and the Washington Heights-Inwood Columbia Aging Project...
October 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28974650/inhibition-of-the-oncogenic-fusion-protein-ews-fli1-causes-g-2-m-cell-cycle-arrest-and-enhanced-vincristine-sensitivity-in-ewing-s-sarcoma
#13
Stefan K Zöllner, Saravana P Selvanathan, Garrett T Graham, Ryan M T Commins, Sung Hyeok Hong, Eric Moseley, Sydney Parks, Jessica N Haladyna, Hayriye V Erkizan, Uta Dirksen, Michael D Hogarty, Aykut Üren, Jeffrey A Toretsky
Ewing's sarcoma (ES) is a rare and highly malignant cancer that grows in the bones or surrounding tissues mostly affecting adolescents and young adults. A chimeric fusion between the RNA binding protein EWS and the ETS family transcription factor FLI1 (EWS-FLI1), which is generated from a chromosomal translocation, is implicated in driving most ES cases by modulation of transcription and alternative splicing. The small-molecule YK-4-279 inhibits EWS-FLI1 function and induces apoptosis in ES cells. We aimed to identify both the underlying mechanism of the drug and potential combination therapies that might enhance its antitumor activity...
October 3, 2017: Science Signaling
https://www.readbyqxmd.com/read/28951454/genomic-landscape-of-atypical-adenomatous-hyperplasia-reveals-divergent-modes-to-lung-adenocarcinoma
#14
Smruthy Sivakumar, F Anthony San Lucas, Tina L McDowell, Wenhua Lang, Li Xu, Junya Fujimoto, Jianjun Zhang, P Andrew Futreal, Junya Fukuoka, Yasushi Yatabe, Steven M Dubinett, Avrum E Spira, Jerry Fowler, Ernest T Hawk, Ignacio I Wistuba, Paul Scheet, Humam Kadara
There is a dearth of knowledge about the pathogenesis of premalignant lung lesions, especially for atypical adenomatous hyperplasia (AAH), the only known precursor for the major lung cancer subtype adenocarcinoma (LUAD). In this study, we performed deep DNA and RNA sequencing analyses of a set of AAH, LUAD, and normal tissues. Somatic BRAF variants were found in AAHs from 5 of 22 (23%) patients, 4 of 5 of whom had matched LUAD with driver EGFR mutations. KRAS mutations were present in AAHs from 4 of 22 (18%) of patients...
November 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28881292/exceptionally-high-ube2c-expression-is-a-unique-phenomenon-in-basal-like-type-breast-cancer-and-is-regulated-by-brca1
#15
Tao Qin, Gena Huang, Liyuan Chi, Silei Sui, Chen Song, Na Li, Siwen Sun, Ning Li, Min Zhang, Zuowei Zhao, Lianhong Li, Man Li
Ubiquitin-conjugating enzyme 2C (UBE2C) is overexpressed in various types of cancer, leading to poor outcomes and drug resistance. UBE2C may also have a critical role in phenotypes associated with poor prognosis in breast cancer; however, the relationship between UBE2C expression and clinical outcome in breast cancer subtypes has not previously been investigated. We firstly analyzed breast cancer patient data and immunohistochemistry of breast cancer patient samples. We demonstrated that UBE2C was associated with poor prognosis in breast cancer, particularly basal-like breast cancer, a subtype with aggressive clinical features...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28767320/forkhead-box-m1-positively-regulates-ube2c-and-protects-glioma-cells-from-autophagic-death
#16
Liang Guo, Zhiming Ding, Nunu Huang, Zhengsong Huang, Nu Zhang, Zhibo Xia
Ubiquitin-conjugating enzyme E2C (UBE2C) is characterized as a crucial molecule in cancer cell growth that plays an essential role in the development of gliomas, but the detailed mechanisms have not been fully elucidated. In this study, we found that Forkhead box transcription factor M1 (FoxM1) overexpression increased UBE2C expression, whereas FoxM1 suppression inhibited UBE2C expression in glioma cells. In addition, high FoxM1/UBE2C expression was significantly correlated with poor prognosis in glioma. We subsequently demonstrated that UBE2C was a direct transcriptional target of FoxM1, and site-directed mutations markedly down-regulated UBE2C promoter activity...
September 17, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28657121/differential-ube2c-and-hoxa1-expression-in-melanocytic-nevi-and-melanoma
#17
Stefan Kraft, Johanna B Moore, Alona Muzikansky, Kenneth L Scott, Lyn M Duncan
BACKGROUND: Recent molecular advances suggest that Spitz nevi and other spitzoid neoplasms are biologically distinct from melanoma and conventional nevi. The ubiquitin ligase UBE2C and the homeobox transcription factor HOXA1 are candidate oncogenes in melanoma. METHODS: Using RNA expression analysis and immunohistochemistry, we evaluated these biomarkers in Spitz nevi (n = 20), melanoma (n = 20), and by immunohistochemistry in conventional nevi (n = 20)...
June 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28650467/genome-wide-loss-of-function-genetic-screening-identifies-opioid-receptor-%C3%AE-1-as-a-key-regulator-of-l-asparaginase-resistance-in-pediatric-acute-lymphoblastic-leukemia
#18
S M Kang, J L Rosales, V Meier-Stephenson, S Kim, K Y Lee, A Narendran
L-asparaginase is a critical chemotherapeutic agent for acute lymphoblastic leukemia (ALL). It hydrolyzes plasma asparagine into aspartate and NH3 , causing asparagine deficit and inhibition of protein synthesis and eventually, leukemic cell death. However, patient relapse often occurs due to development of resistance. The molecular mechanism by which ALL cells acquire resistance to L-asparaginase is unknown. Therefore, we sought to identify genes that are involved in L-asparaginase resistance in primary leukemic cells...
October 19, 2017: Oncogene
https://www.readbyqxmd.com/read/28487115/lncrna-hoxd-as1-regulates-proliferation-and-chemo-resistance-of-castration-resistant-prostate-cancer-via-recruiting-wdr5
#19
Peng Gu, Xu Chen, Ruihui Xie, Jinli Han, Weibin Xie, Bo Wang, Wen Dong, Changhao Chen, Meihua Yang, Junyi Jiang, Ziyue Chen, Jian Huang, Tianxin Lin
Castration-resistant prostate cancer (CRPC) that occurs after the failure of androgen deprivation therapy is the leading cause of deaths in prostate cancer patients. Thus, there is an obvious and urgent need to fully understand the mechanism of CRPC and discover novel therapeutic targets. Long noncoding RNAs (lncRNAs) are crucial regulators in many human cancers, yet their potential roles and molecular mechanisms in CRPC are poorly understood. In this study, we discovered that an lncRNA HOXD-AS1 is highly expressed in CRPC cells and correlated closely with Gleason score, T stage, lymph nodes metastasis, and progression-free survival...
August 2, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28479381/integrated-clinicopathological-features-and-gene-microarray-analysis-of-pancreatic-neuroendocrine-tumors
#20
Huaqiang Zhou, Qinchang Chen, Wulin Tan, Zeting Qiu, Si Li, Yiyan Song, Shaowei Gao
Pancreatic neuroendocrine tumors are relatively rare pancreatic neoplasms over the world. Investigations about molecular biology of PNETs are insufficient for nowadays. We aimed to explore the expression of messenger RNA and regulatory processes underlying pancreatic neuroendocrine tumors from different views. The expression profile of GSE73338 were downloaded, including samples with pancreatic neuroendocrine tumors. First, the Limma package was utilized to distinguish the differentially expressed messenger RNA...
August 20, 2017: Gene
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