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necrotizing enterocolitis treatment

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https://www.readbyqxmd.com/read/29739367/impact-of-umbilical-cord-milking-and-pasteurized-donor-human-milk-on-necrotizing-enterocolitis-a-retrospective-review
#1
Mehtab K Sekhon, Bradley A Yoder
BACKGROUND: Necrotizing enterocolitis (NEC) is a serious complication of prematurity. Our objective was to evaluate the impact of an umbilical cord milking protocol (UCM) and pasteurized donor human milk (PDHM) on NEC rates in infants less than 30 weeks gestational age from January 1, 2010 to September 30, 2016. We hypothesized an incremental decrease in NEC after each intervention. METHODS: We performed a retrospective review of 638 infants born less than 30 weeks gestational age...
May 8, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29721677/value-of-abdominal-ultrasound-in-management-of-necrotizing-enterocolitis-a-systematic-review-and-meta-analysis
#2
Maarten Janssen Lok, Hiromu Miyake, Alison Hock, Alan Daneman, Agostino Pierro, Martin Offringa
PURPOSE: Necrotizing enterocolitis (NEC) remains a life-threatening disease among infants in the NICU. Early diagnosis and careful monitoring are essential to improve outcomes. Abdominal ultrasound (AUS) seems a promising addition to current diagnostic modalities, but its clinical utility is uncertain. The aim of this study was to identify AUS features associated with definite NEC (i.e. Bell stage ≥ II), failed medical treatment, surgery, and death. METHODS: Embase, MEDLINE, Web of Science and CINAHL databases were searched for studies that addressed any NEC-related AUS feature in relation to any of the four outcomes...
May 2, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29699808/vitamin-a-and-retinoic-acid-exhibit-protective-effects-on-necrotizing-enterocolitis-by-regulating-intestinal-flora-and-enhancing-the-intestinal-epithelial-barrier
#3
Sa Xiao, Qiuping Li, Kun Hu, Yu He, Qing Ai, Liuhong Hu, Jialin Yu
BACKGROUND: Exaggerated inflammation that characterizes necrotizing enterocolitis (NEC) is caused by the invasion of pathogens through an immature intestinal barrier. Vitamin A (VA) and retinoic acid (RA) play important roles in the growth of epithelial tissue and in modulating immune function. OBJECTIVE: To investigate the roles of VA and RA in the development of NEC. METHODS: Levels of serum retinol in patients and in a NEC mouse model were detected with high-performance liquid chromatography...
April 23, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29695206/efficacy-and-safety-of-oral-paracetamol-versus-oral-ibuprofen-for-closure-of-patent-ductus-arteriosus-in-preterm-infants-a-randomized-controlled-trial
#4
Rania A El-Farrash, Mohammed S El Shimy, Abeer S El-Sakka, Manal G Ahmed, Dina G Abdel-Moez
OBJECTIVE: To evaluate the efficacy and safety of oral paracetamol versus oral ibuprofen in the treatment of hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants. STUDY DESIGN: An interventional randomized case-control study, registered in ClinicalTrials.gov ( NCT03265782 ), was conducted on 60 preterm infants with gestational age ≤ 34 weeks, postnatal age of 2-7 days and color Doppler echocardiographic evidence of hsPDA. Neonates were randomly assigned to two groups; 30 received oral ibuprofen and 30 received oral paracetamol...
April 25, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29686534/the-neurodevelopmental-perspective-of-surgical-necrotizing-enterocolitis-the-role-of-the-gut-brain-axis
#5
REVIEW
Chariton Moschopoulos, Panagiotis Kratimenos, Ioannis Koutroulis, Bhairav V Shah, Anja Mowes, Vineet Bhandari
This state-of-the-art review article aims to highlight the most recent evidence about the therapeutic options of surgical necrotizing enterocolitis, focusing on the molecular basis of the gut-brain axis in relevance to the neurodevelopmental outcomes of primary peritoneal drainage and primary laparotomy. Current evidence favors primary laparotomy over primary peritoneal drainage as regards neurodevelopment in the surgical treatment of necrotizing enterocolitis. The added exposure to inhalational anesthesia in infants undergoing primary laparotomy is an additional confounding variable but requires further study...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29661576/treatment-of-experimental-necrotizing-enterocolitis-with-stem-cell-derived-exosomes
#6
Christopher J McCulloh, Jacob K Olson, Yijie Wang, Yu Zhou, Natalie Huibregtse Tengberg, Shivani Deshpande, Gail E Besner
PURPOSE: Necrotizing enterocolitis (NEC) remains a devastating disease in premature infants. We previously showed that four stem cell (SC) types equivalently improve experimental NEC. Exosomes are intercellular nanovesicles containing RNA, miRNA, DNA, and protein. Because SC therapy faces challenges, our aim was to determine if the beneficial effects of SC are achievable with cell-free exosomes. METHODS: Exosomes from four SC types were compared: (1) amniotic fluid-derived mesenchymal SC (AF-MSC); (2) bone marrow-derived MSC (BM-MSC); (3) amniotic fluid-derived neural SC (AF-NSC); and (4) neonatal enteric NSC (E-NSC)...
March 14, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29658462/-research-advances-in-immune-tolerance-of-allogeneic-cell-transplantation-in-preterm-infants
#7
Can Lyu, Yi Qu, De-Zhi Mu
Preterm infants are a special group, and related severe neurological, respiratory, and digestive disorders have high disability/fatality rates. Allogeneic cell transplantation may be an effective method for the prevention and treatment of these diseases. At present, animal studies have been conducted for allogeneic cell transplantation in the treatment of hypoxic-ischemic encephalopathy, bronchopulmonary dysplasia, and necrotizing enterocolitis. The main difficulty of this technique is graft-versus-host reaction (GVHR), and successful induction of immune tolerance needs to be achieved in order to solve this problem...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29657735/necrotizing-enterocolitis-associated-with-clostridium-butyricum-in-a-japanese-man
#8
Yukio Sato, Dai Kujirai, Katsura Emoto, Toshiaki Yagami, Taketo Yamada, Manabu Izumi, Masaki Ano, Kenichi Kase, Kenji Kobayashi
Case: Necrotizing enterocolitis (NEC) caused by Clostridium butyricum is common in neonates; however, a case of NEC in adults has not been previously reported. An 84-year-old Japanese man developed C. butyricum -related NEC during hospitalization for treatment of stab wounds to the left side of the neck and lower abdomen, without organ damage, and concomitant pneumonia. Outcome: The patient developed acute onset of emesis accompanied by shock during his admission; partial resection of the small intestine was carried out due to necrosis...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29648878/protective-effect-of-lactobacillus-reuteri-dsm-17938-against-experimental-necrotizing-enterocolitis-is-mediated-by-toll-like-receptor-2
#9
Thomas K Hoang, Baokun He, Ting Wang, Dat Q Tran, Jon Marc Rhoads, Yuying Liu
Lactobacillus reuteri DSM 17938 (LR 17938) has been shown to reduce the incidence and severity of necrotizing enterocolitis (NEC). It is unclear if preventing NEC by LR 17938 is mediated by toll-like receptor 2 (TLR2), which is known to mediate pro-inflammatory responses to bacterial cell wall components. NEC was induced in newborn TLR2-/- or WT mice by the combination of gavage-feeding cow milk-based formula and exposure to hypoxia and cold stress. Treatment groups were administered formula supplemented with LR 17938 or placebo (MRS media)...
April 12, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29644455/neonatal-independent-predictors-of-severe-nec
#10
Miriam Duci, Francesco Fascetti-Leon, Marta Erculiani, Elena Priante, Maria Elena Cavicchiolo, Giovanna Verlato, Piergiorgio Gamba
PURPOSE: Necrotizing enterocolitis (NEC) is a severe neonatal disease. The present study aimed to identify factors predisposing the development of severe forms of NEC. METHODS: This retrospective study examined NEC patients in a single centre between 2002 and 2015. Data concerning clinical characteristics, therapeutic management as well as short-term outcomes were collected. We compared the patients receiving successful medical treatment and those requiring surgical intervention...
April 11, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29622398/time-to-reintroduction-of-feeding-in-infants-with-nonsurgical-necrotizing-enterocolitis
#11
Chase A Arbra, Andra Oprisan, Dulaney A Wilson, Rita M Ryan, Aaron P Lesher
BACKGROUND: For infants with necrotizing enterocolitis (NEC) treated nonoperatively, no consensus exists on the optimal fasting period prior to reintroducing feeds after NEC. We report our experience with early (<7days) and late (≥7days) refeeding in this population. METHODS: A chart review of infants with NEC born between 2006 and 2016 was performed. Data elements include demographics, comorbidities, day of diagnosis, Bell's stage, recurrence, strictures, length of stay and mortality, and were grouped into early and late refeeding...
March 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29602968/comparison-of-abdominal-radiographs-and-sonography-in-prognostic-prediction-of-infants-with-necrotizing-enterocolitis
#12
Shuai Chen, Yuanjun Hu, Qinghua Liu, Xiaoying Li, Hefeng Wang, Kelai Wang
PURPOSE: The purpose of this study was to investigate the comparison of AR and AUS in predicting prognosis in infants with necrotizing enterocolitis. METHODS: All patients were diagnosed as NEC at the department of general surgery and neonatal surgery, Qilu children's hospital between 1st, Jun, 2010 and 30th, Dec, 2016. The logistic regression analysis and the area under ROC curve (AUC)s were also used to compare the prognostic values of radiograph and sonograph for NEC...
March 30, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29594085/stress-signals-during-sucking-activity-are-associated-with-longer-transition-time-to-full-oral-feeding-in-premature-infants
#13
You Gyoung Yi, Byung-Mo Oh, Seung Han Shin, Jin Yong Shin, Ee-Kyung Kim, Hyung-Ik Shin
Several treatments have been proposed to shorten the time to the attainment of full oral feeding (FOF) for premature infants, but there are only a few evaluation methods useful in estimating predictors of this period. We investigated whether specific items within the disorganized sucking patterns described by the Neonatal Oral-Motor Assessment Scale (NOMAS) could estimate the time to FOF in preterm infants with feeding difficulty. Preterm infants diagnosed with a disorganized sucking pattern in the NOMAS evaluation before 50 weeks of postmenstrual age were included...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29584842/association-of-placebo-indomethacin-ibuprofen-and-acetaminophen-with-closure-of-hemodynamically-significant-patent-ductus-arteriosus-in-preterm-infants-a-systematic-review-and-meta-analysis
#14
REVIEW
Souvik Mitra, Ivan D Florez, Maria E Tamayo, Lawrence Mbuagbaw, Thuva Vanniyasingam, Areti Angeliki Veroniki, Adriana M Zea, Yuan Zhang, Behnam Sadeghirad, Lehana Thabane
Importance: Despite increasing emphasis on conservative management of patent ductus arteriosus (PDA) in preterm infants, different pharmacotherapeutic interventions are used to treat those developing a hemodynamically significant PDA. Objectives: To estimate the relative likelihood of hemodynamically significant PDA closure with common pharmacotherapeutic interventions and to compare adverse event rates. Data Sources and Study Selection: The databases of MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched from inception until August 15, 2015, and updated on December 31, 2017, along with conference proceedings up to December 2017...
March 27, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29545879/berberine-ameliorates-neonatal-necrotizing-enterocolitis-by-activating-the-phosphoinositide-3-kinase-protein-kinase-b-signaling-pathway
#15
Chengzhi Fang, Lili Xie, Chunmei Liu, Chunhua Fu, Wei Ye, Hong Liu, Binghong Zhang
Neonatal necrotizing enterocolitis (NEC) is a severe acquired disease that predominantly affects the small intestine of neonates. NEC is caused by a combination of metabolic products, dysfunctions of the blood vessels, mucus and other unknown factors. Berberine may induce beneficial effects on necrotic and cardiovascular diseases due to its anti-inflammatory and anti-apoptotic effects on epithelial cells. In the present study, the therapeutic effects of berberine were investigated and the potential mechanisms by which it functions within a neonatal NEC mouse model were analyzed...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29534255/perioperative-complications-following-surgery-for-necrotizing-enterocolitis
#16
REVIEW
Annika Mutanen, Agostino Pierro, Augusto Zani
Necrotizing enterocolitis (NEC) is a devastating condition that mainly affects premature infants. Advanced cases of NEC require surgical treatment, which in up to 70% of infants is associated with significant perioperative morbidity including anastomosis- or enterostomy-related complications, sepsis, peritonitis, and wound infections. Moreover, the perioperative complications may compromise the long-term gastrointestinal and neurodevelopmental outcome of patients requiring surgery for NEC.
April 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29531394/effectiveness-of-injectable-ibuprofen-salts-and-indomethacin-to-treat-patent-ductus-arteriosus-in-preterm-infants-observational-cohort-study
#17
Deonne Dersch-Mills, Belal Alshaikh, Amuchou S Soraisham, Albert Akierman, Kamran Yusuf
Background: There is no injectable ibuprofen product marketed to treat patent ductus arteriosus (PDA) in newborns in Canada. The authors' institution has used ibuprofen arginine in the past. In the absence of published evidence supporting use of this salt form of ibuprofen for neonatal PDA, a retrospective analysis was undertaken. Objective: To compare the effectiveness and adverse effects of ibuprofen arginine, ibuprofen tromethamine, and indomethacin in the treatment of PDA...
January 2018: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/29530124/-effect-of-bifidobacterium-on-the-expression-of-%C3%AE-defensin-2-in-intestinal-tissue-of-neonatal-rats-with-necrotizing-enterocolitis
#18
Wei-Cheng Lu, Xu Zheng, Jin-Fu Liu, Wen-Chuan Wu, Xing-Yue Chen, Hai-Bo Wei, Chun-Lei Li, Ming-Jing Lin
OBJECTIVE: To study the effect of Bifidobacterium on the expression of β-defensin-2 (BD-2) in intestinal tissue of neonatal rats with necrotizing enterocolitis (NEC). METHODS: A total of 40 rats were randomly divided into four groups: normal control, Bifidobacterium control, NEC model, and Bifidobacterium treatment, with 10 rats in each group. A rat model of NEC was induced by hypoxia, cold stimulation, and artificial feeding. The rats in the Bifidobacterium control and Bifidobacterium treatment groups were given Bifidobacterium via the gastric tube after cold stimulation once a day for three consecutive days...
March 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29529231/early-progressive-feeding-in-extremely-preterm-infants-a-randomized-trial
#19
Ariel A Salas, Peng Li, Kelli Parks, Charitharth V Lal, Camilia R Martin, Waldemar A Carlo
Background: Due to insufficient evidence, extremely preterm infants (≤28 wk of gestation) rarely receive early progressive feeding (small increments of feeding volumes between 1 and 4 d after birth). We hypothesized that early progressive feeding increases the number of full enteral feeding days in the first month after birth. Objective: The aim of this study was to determine the feasibility and efficacy of early progressive feeding in extremely preterm infants...
March 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29503274/cytomegalovirus-enterocolitis-in-a-term-neonate
#20
Siva Prasad Vyasam, Thangaraj Abiramalatha, Nalapalu Srinivasan Hema, Niranjan Thomas
BACKGROUND: Cytomegalovirus (CMV) enterocolitis is rare in term neonates. CASE CHARACTERISTICS: A term newborn with persistent pneumonia from birth developed enterocolitis on day 18 of life. OUTCOME: Polymerase chain reaction (PCR) for CMV DNA was positive in urine sample. Antiviral therapy for six weeks resulted in successful treatment without any stricture formation. MESSAGE: CMV enterocolitis should be considered as a differential diagnosis in atypical cases of necrotizing enterocolitis in neonates...
February 15, 2018: Indian Pediatrics
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