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https://www.readbyqxmd.com/read/29777040/obe022-an-oral-and-selective-prostaglandin-f2%C3%AE-receptor-antagonist-as-an-effective-and-safe-modality-for-the-treatment-of-preterm-labor
#1
Oliver Pohl, Andre Chollet, Sung Hye Kim, Lucia Riaposova, Francois Spezia, Frederic Gervais, Philippe Guillaume, Philippe Lluel, Murielle Meen, Frederique Lemaux, Vasso Terzidou, Phillip R Bennett, Jean-Pierre Gotteland
Preterm birth is the major challenge in obstetrics affecting ~10% of pregnancies. Pan-prostaglandin synthesis inhibitors (NSAID) prevent preterm labor and prolong pregnancy but raise concerns about fetal renal and cardiovascular safety. We conducted preclinical studies examining the tocolytic effect and fetal safety of the oral prodrug candidate OBE022 and its parent OBE002, both potent and highly selective antagonist of the contractile PGF2α prostaglandin receptor (FP). Efficacy of OBE022 and OBE002, alone and in combination with other tocolytics, was assessed in human tissues and pregnant animal models for inhibition of uterine contraction and delay of parturition...
May 18, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29771920/maternal-human-telomerase-reverse-transcriptase-variants-are-associated-with-preterm-labor-and-preterm-premature-rupture-of-membranes
#2
Caroline Marrs, Kevin Chesmore, Ramkumar Menon, Scott Williams
OBJECTIVE: Premature aging and short telomere lengths of fetal tissues are associated with spontaneous preterm labor (PTL) and preterm premature rupture of membranes (pPROM). Maintenance of telomere length is performed by the enzyme telomerase. Human telomerase reverse transcriptase (hTERT) is a subunit of telomerase, and its dysfunction affects telomere shortening. This study assessed whether maternal or fetal genetic variations in the hTERT gene are associated with PTL or pPROM. METHODS: A case (PTL or pPROM) control (term birth) genetic association study was conducted in 654 non-Hispanic white mothers (438 term, 162 PTL, 54 pPROM) and 502 non-Hispanic white newborns (346 term, 116 PTB, 40 pPROM)...
2018: PloS One
https://www.readbyqxmd.com/read/29766152/undesired-effect-of-excessive-betamethasone-administration-during-pregnancy-a-rare-case
#3
Alireza Mirzaei, Solmaz Piri, Kaveh Gharanizadeh, Mozhdeh Zabihiyeganeh
Background: Postpartum bilateral femoral neck fracture (BFNF) is a rare condition. We here report a case of BFNF due to excessive corticosteroid consumption, twin pregnancy, immobility, and vitamin D deficiency. Case: This is a report of a 32-yr-old woman with bilateral femoral insufficiency fracture five days after emergency cesarean section due to preterm labor, twin pregnancy, and the history of a previous cesarean section at 33 wk. Antenatal repeated courses of betamethasone injections for fetal lung maturity, daily oral use of prednisolone for the history of miscarriage, immobilization, and vitamin D deficiency were the important contributing factors in her past medical history and lab investigations...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29764243/the-cost-of-preterm-labor-and-preterm-birth-for-mothers-with-uncomplicated-pregnancies-and-their-infants-in-italy-a-retrospective-cohort-study
#4
Evie Merinopoulou, Shibani Pokras, Jeanne M Pimenta, Valerio Blini, Chiara Veronesi, Stefano Buda, Luca Degli Esposti, Dimitra Lambrelli
BACKGROUND: Preterm labor (PTL)/preterm birth (PTB) impose significant burden on healthcare systems. Women with uncomplicated pregnancies at risk of PTL/PTB have not been widely investigated, and published evidence on the costs of these women and their infants in Italy is absent. We aimed to describe women with uncomplicated pregnancies and associated costs for these women and their infants. METHODS: Data on women aged 12-44 years with uncomplicated pregnancies who delivered between 1/9/2009-31/12/2014 with PTL diagnosis alone or PTL and PTB, were included from four Italian databases...
May 15, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29759046/classification-of-preterm-birth-with-placental-correlates
#5
Karen M Chisholm, Mary E Norton, Anna A Penn, Amy Heerema-McKenney
Premature birth lacks a widely accepted classification that unites features of the clinical presentation with placental pathology. To further explore associations between the clinical categories of preterm birth and placental histology, 109 infants with gestational age <34 weeks and birth weight <2000 g were selected and, based on electronic records, were classified into preterm birth categories of preterm labor, prelabor premature rupture of membranes, preeclampsia, indicated preterm birth for maternal factors (other than preeclampsia), indicated preterm birth for fetal factors, and the clinical diagnosis of abruption...
January 1, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29758543/magnesium-sulfate-versus-esomeprazole-impact-on-the-neonates-of-preeclamptic-rats
#6
Amani N Shafik, Mahmoud A Khattab, Ahmed H Osman
OBJECTIVE: Preeclampsia represents a major complication of pregnancy, associated with greater maternal and fetal complications. We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats. STUDY DESIGN: Preeclampsia was induced in pregnant rats with NG-nitro-l-arginine methyl ester (L-NAME) starting from day 10-till end of pregnancy...
May 8, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29758096/low-maternal-serum-concentrations-of-mannose-binding-lectin-mbl-are-associated-with-the-risk-of-shorter-duration-of-pregnancy-and-lower-birth-weight
#7
Michal Koucký, Karin Malíčková, Helena Kopřivová, Tereza Cindrová-Davies, Hana Hrbáčková, Andrej Černý, Patrik Šimják, Antonín Pařízek, Tomáš Zima
BACKROUND: Chronic inflammation has been implicated as the underlying mechanism responsible for the pathophysiology of preterm labor. Mannose-bindig lectin (MBL) plays a central role in the innate immune response and is thus an important component of the first line of defense. The aim of this study was to investigate whether serum concentrations of MBL correlated with the incidence of preterm birth and low birth weight in a cohort of women with signs of threatened preterm birth. METHODS: A cohort of 60 patients who presented with regular contractions and/or short cervix (group A) between 24 to 32 weeks of gestation and 20 healthy controls (group B) who had no pregnancy complications and delivered at term were recruited into a prospective study...
May 14, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29757275/isolation-of-primary-human-decidual-cells-from-the-fetal-membranes-of-term-placentae
#8
Tali Farine, Michael Parsons, Stephen Lye, Oksana Shynlova
The decidua, also known as the pregnant endometrium, is a critically important reproductive tissue. Decidual cells, comprised mainly of decidualized stromal cells and immune cells, are responsible for the secretion of hormonal and inflammatory factors which are critical for successful blastocyst implantation, placental development and play a role in the initiation of labor at term and preterm. Many pregnancy complications can arise from perturbations of a fine balance of different cell populations comprising decidua...
April 30, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29747211/tocolysis-among-women-with-preterm-birth-associated-factors-and-outcomes-from-a-multicenter-study-in-brazil
#9
Tabata Zumpano Dias, Mariana Lacerda Fava, Renato Passini Júnior, Jose Guilherme Cecatti, Ricardo Porto Tedesco, Giuliane Jesus Lajos, Patricia Moretti Rehder, Marcelo Luis Nomura, Paulo Fanti Oliveira, Maria Laura Costa
OBJECTIVE:  To evaluate the use of tocolysis in cases of preterm birth due to spontaneous preterm labor in a Brazilian sample. METHODS:  A sample of 1,491 women with preterm birth due to spontaneous preterm labor were assessed, considering treatment with tocolysis or expectant management, according to gestational age at birth (< 34 weeks and 34 to 36 + 6 weeks) and drugs prescribed. The study took place in 20 Brazilian hospitals from April 2011 to July 2012...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29743041/plasma-inflammatory-and-immune-proteins-as-predictors-of-intra-amniotic-infection-and-spontaneous-preterm-delivery-in-women-with-preterm-labor-a-retrospective-study
#10
Hyunsoo Park, Kyo Hoon Park, Yu Mi Kim, Song Yi Kook, Se Jeong Jeon, Ha-Na Yoo
BACKGROUND: We investigated whether various inflammatory and immune proteins in plasma predict intra-amniotic infection and imminent preterm delivery in women with preterm labor and compared their predictive ability with that of amniotic fluid (AF) interleukin (IL)-6 and serum C-reactive protein (CRP). METHODS: This retrospective cohort study included 173 consecutive women with preterm labor who underwent amniocentesis for diagnosis of infection and/or inflammation in the AF...
May 9, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29727248/quantitative-fetal-fibronectin-and-cervical-length-in-symptomatic-women-results-from-a-prospective-blinded-cohort-study
#11
Lisa D Levine, Katheryne L Downes, Julie A Romero, Hope Pappas, Michal A Elovitz
OBJECTIVES: Our objectives were to determine whether quantitative fetal fibronectin (fFN) and cervical length (CL) screening can be used alone or in combination as prognostic tests to identify symptomatic women at highest or lowest risk for spontaneous preterm birth (sPTB). METHODS: A prospective, blinded cohort study of women presenting with a singleton gestation to our triage unit between 22-33w6d with preterm labor symptoms was performed. Women with ruptured membranes, moderate/severe bleeding, and dilation > 2 cm were excluded...
May 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29709096/17ohp-c-in-patients-with-spontaneous-preterm-labor-and-intact-membranes-is-there-an-effect-according-to-the-presence-of-intra-amniotic-inflammation
#12
Satoshi Yoneda, Noriko Yoneda, Arihiro Shiozaki, Osamu Yoshino, Tomohiro Ueno, Hideki Niimi, Isao Kitajima, Kentaro Tamura, Yukako Kawasaki, Masami Makimoto, Taketoshi Yoshida, Shigeru Saito
PROBLEM: It is not known whether 17-alpha-hydroxyprogesterone caproate (17OHP-C) is effective for preventing preterm delivery with an episode of preterm labor (PTL) with or without intra-amniotic inflammation/infection. METHODS OF STUDY: This was a retrospective cohort study. One hundred and seven PTL patients were selected and divided into a 17OHP-C group (use of 17OHP-C: n = 53) and a no-treatment group (no use of 17OHP-C: n = 54). Moreover, the patients were divided into three subgroups (subgroup A: without intra-amniotic inflammation, B: with mild intra-amniotic inflammation, and C: with severe intra-amniotic inflammation) according to their level of amniotic interleukin (IL)-8, and perinatal prognosis was analyzed...
April 30, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29706318/premature-labor-and-neonatal-sepsis-caused-by-actinomyces-neuii
#13
Fahad Alsohime, Rasha A Assiri, Fatimah Al-Shahrani, Hind Bakeet, Malak Elhazmi, Ali M Somily
Actinomycosis is a rare infection in patients younger than 10years of age. It mainly affects the cervicofacial region, but many other sites of infection have been recognized. About 70% of infections are due to either Actinomyces israelii or Actinomyces gerencseriae. Actinomyces neuii was first described in 1985 in two patients with post cataract endophthalmitis, A. neuii represents 17% of clinical Actinomyces isolates. Several reports indicated a well-known association between Actinomyces infections and Intrauterine devices (IUD)...
April 26, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29704487/cervical-pessary-to-reduce-preterm-birth-before-34-weeks-of-gestation-after-an-episode-of-preterm-labor-and-a-short-cervix-a-randomized-controlled-trial
#14
Laia Pratcorona, Maria Goya, Carme Merced, Carlota Rodó, Elisa Llurba, Teresa Higueras, Luis Cabero, Elena Carreras
BACKGROUND: To date, no intervention has proved effective in reducing the spontaneous preterm birth rate in singleton pregnancies following an episode of threatened preterm labor and short cervix remaining. OBJECTIVE: This study was designed to ascertain whether cervical pessaries could be useful in preventing spontaneous preterm birth in women with singleton pregnancies and a short cervix after a threatened preterm labor episode. STUDY DESIGN: This open randomized controlled trial was conducted in 357 pregnant women (between 240 and 336 weeks) who had not delivered 48h after a threatened preterm labor episode and had a short cervix remaining (≤25 mm at 240 -296 weeks; ≤15mm at 300 -336 weeks)...
April 25, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29703554/the-biological-basis-and-prevention-of-preterm-birth
#15
REVIEW
Gian Carlo Di Renzo, Valentina Tosto, Irene Giardina
The time of birth is a critical determinant of perinatal and long-term outcomes. Preterm birth is still the first cause of infant mortality and morbidity; unfortunately, rates of preterm birth remain high in both high- and low-resource countries, ranging from 5% to 18%. Preterm parturition is a syndrome, which can be induced by various factors such as infection, cervical pathology, uterine overdistension, progesterone deficiency, vascular alterations (utero-placental ischemia, decidual hemorrhage), maternal and fetal stress, allograft reaction, allergic phenomena, and probably other several unknown factors...
February 16, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29702270/adnexal-torsion-during-pregnancy-pregnancy-outcomes-after-surgical-intervention-a-retrospective-case-control-study
#16
Yair Daykan, Rona Bogin, Merav Sharvit, Zvi Klein, Dana Josephy, Meir Pomeranz, Nissim Arbib, Tal Biron-Shental, Ron Schonman
STUDY OBJECTIVE: To investigate the pregnancy and neonatal outcomes of surgical treatment for adnexal torsion (AT) during pregnancy. DESIGN: Retrospective case-control study (Canadian Task Force classification II-2). SETTING: Tertiary care academic medical center. MEASUREMENTS AND RESULTS: The study group included all parturients who underwent surgery for suspected AT during pregnancy from January 2005 to January 2017...
April 24, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29695455/alloreactive-fetal-t-cells-promote-uterine-contractility-in-preterm-labor-via-ifn-%C3%AE-and-tnf-%C3%AE
#17
Michela Frascoli, Lacy Coniglio, Russell Witt, Cerine Jeanty, Shannon Fleck-Derderian, Dana E Myers, Tzong-Hae Lee, Sheila Keating, Michael P Busch, Philip J Norris, Qizhi Tang, Giovanna Cruz, Lisa F Barcellos, Nardhy Gomez-Lopez, Roberto Romero, Tippi C MacKenzie
Healthy pregnancy is the most successful form of graft tolerance, whereas preterm labor (PTL) may represent a breakdown in maternal-fetal tolerance. Although maternal immune responses have been implicated in pregnancy complications, fetal immune responses against maternal antigens are often not considered. To examine the fetal immune system in the relevant clinical setting, we analyzed maternal and cord blood in patients with PTL and healthy term controls. We report here that the cord blood of preterm infants has higher amounts of inflammatory cytokines and a greater activation of dendritic cells...
April 25, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29670470/maternal-plasma-metabolomic-profiles-in-spontaneous-preterm-birth-preliminary-results
#18
Barbara Lizewska, Joanna Teul, Pawel Kuc, Adam Lemancewicz, Karol Charkiewicz, Joanna Goscik, Marian Kacerovsky, Ramkumar Menon, Wojciech Miltyk, Piotr Laudanski
Objective: To profile maternal plasma metabolome in spontaneous preterm birth. Method: In this retrospective case-control study, we have examined plasma of patient with preterm birth (between 22 and 36 weeks of pregnancy ( n = 57)), with threatened preterm labor (between 23 and 36 weeks of pregnancy ( n = 49)), and with term delivery ( n = 25). Plasma samples were analysed using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) in positive and negative polarity modes...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29670041/comparative-evaluation-of-arabin-pessary-and-cervical-cerclage-for-the-prevention-of-preterm-labor-in-asymptomatic-women-with-high-risk-factors
#19
Panagiotis Tsikouras, George Anastasopoulos, Vasileios Maroulis, Anastasia Bothou, Anna Chalkidou, Dorelia Deuteraiou, Xanthoula Anthoulaki, Georgios Tsatsaris, Arzou Halil Bourazan, George Iatrakis, Stefanos Zervoudis, Georgios Galazios, Lola-Katerina Inagamova, Roland Csorba, Alexander-Tobias Teichmann
OBJECTIVE: Preterm labor is one of the most significant obstetric problems associated with high rate of actual and long-term perinatal complications. Despite the creation of scoring systems, uterine activity monitoring, cervical ultrasound and several biochemical markers, the prediction and prevention of preterm labor is still a matter of concern. The aim of this study was to examine cervical findings for the prediction and the comparative use of Arabin pessary or cerclage for the prevention of preterm birth in asymptomatic women with high risk factors for preterm labor...
April 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29668583/a-prisma-systematic-review-and-meta-analysis-on-chlamydia-trachomatis-infections-in-iranian-women-1986-2015
#20
Daem Roshani, Rashid Ramazanzadeh, Fariba Farhadifar, Amjad Ahmadi, Safoura Derakhshan, Samaneh Rouhi, Shamsi Zarea, Farnaz Zandvakili
BACKGROUND: Chlamydia trachomatis (CT) is the cause of genital tract infections in women. Some evidence has shown the role of this infection with CT in spontaneous abortions. The purpose of this study is to study the frequency of CT infection in Iranian women. METHODS: This study was performed based on PRISMA guidelines. A total of 75 articles published in Google Scholar, PubMed, ISI Web of Science, Biological abs, Iranmedex, SID, and Scopus databases were found (1986-2015) using the following keywords: CT in women, CT and Iranian women, CT and infection in Iran, CT and pregnancy in Iran, CT and preterm delivery in Iran, CT and preterm labor in Iran, CT and fertility in Iran, CT and infertility in Iran, and CT and abortion in Iran...
April 2018: Medicine (Baltimore)
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