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https://www.readbyqxmd.com/read/29411291/post-liver-transplantation-diabetes-mellitus-a-review-of-relevance-and-approach-to-treatment
#1
REVIEW
Maria J Peláez-Jaramillo, Allison A Cárdenas-Mojica, Paula V Gaete, Carlos O Mendivil
Post-liver transplantation diabetes mellitus (PLTDM) develops in up to 30% of liver transplant recipients and is associated with increased risk of mortality and multiple morbid outcomes. PLTDM is a multicausal disorder, but the main risk factor is the use of immunosuppressive agents of the calcineurin inhibitor (CNI) family (tacrolimus and cyclosporine). Additional factors, such as pre-transplant overweight, nonalcoholic steatohepatitis and hepatitis C virus infection, may further increase risk of developing PLTDM...
February 6, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29403152/adrenocortical-carcinoma-characterized-by-gynecomastia-a-case-report
#2
Takako Takeuchi, Yuko Yoto, Akira Ishii, Takeshi Tsugawa, Masaki Yamamoto, Tsukasa Hori, Hotaka Kamasaki, Kazutaka Nogami, Takanori Oda, Akihiro Nui, Sachiko Kimura, Takuya Yamagishi, Keiko Homma, Tomonobu Hasegawa, Maki Fukami, Yoko Watanabe, Hidehiko Sasamoto, Hiroyuki Tsutsumi
We present a 4-yr-old boy with adrenocortical carcinoma (ACC), diagnosed due to the appearance of gynecomastia as the presenting symptom. Six months prior to admission, an acute growth spurt along with the development of bilateral breast swelling was observed. He did not present any features of virilization, including enlargement of the testes, increase in testis volume, and penis size. Laboratory investigations showed gonadotropin-independent hypergonadism, with low LH/ FSH levels and elevated estradiol/testosterone levels...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29394550/-a-patient-with-basaloid-carcinoma-of-the-esophagus-removed-surgically-after-pre-operative-chemotherapy-who-developed-ttp-during-post-operative-chemotherapy
#3
Akemi Watanabe, Hiroyuki Fukunari, Yousuke Kawai, Makoto Aoki, Satoshi Saito, Yuya Umebayashi, Kenji Shitara, Tetsuji Hayashi, Gen Watanabe, Hiroshi Ajioka
A 63-year-old man presented with the chief complaint of an unpleasant feeling in the chest after a meal.Esophagogastroduodenoscopy revealed interminglement of ulcer infiltration type lesions and protruding lesions in the lower esophagus.A large type 1 protruding lesion was located mainly in the esophagogastric junction(EGJ)and it progressed towards the stomach.A hypertrophic and protruding lesion on the lower esophageal wall and a 6 cm tumor in the major axis of the fornix were observed on thoracic and abdominal CT, and an endocrine cell carcinoma or basaloid carcinoma were suggested after biopsy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29389252/risk-factors-and-predictive-model-development-of-thirty-day-post-operative-surgical-site-infection-in-the-veterans-administration-surgical-population
#4
Xinli Li, William Nylander, Tracy Smith, Soonhee Han, William Gunnar
BACKGROUND: Surgical site infection (SSI) complicates approximately 2% of surgeries in the Veterans Affairs (VA) hospitals. Surgical site infections are responsible for increased morbidity, length of hospital stay, cost, and mortality. Surgical site infection can be minimized by modifying risk factors. In this study, we identified risk factors and developed accurate predictive surgical specialty-specific SSI risk prediction models for the Veterans Health Administration (VHA) surgery population...
February 1, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29356715/post-operative-inflammation-after-endoscopic-cyclophotocoagulation-racial-distribution-and-effect-on-outcomes
#5
Anna M Edmiston, Jeffrey R SooHoo, Leonard K Seibold, Malik Y Kahook, Alan G Palestine, Mina B Pantcheva
PURPOSE: To assess the prevalence of post-operative anterior chamber reaction or persistent anterior uveitis by race and its effect on intraocular pressure and visual acuity after combined phacoemulsification and endoscopic cyclophotocoagulation in primary open angle glaucoma. PATIENTS AND METHODS: A retrospective analysis of all patients with primary open angle glaucoma who underwent combined phacoemulsification cataract extraction with endoscopic cyclophotocoagulation from January 1, 2007 to October 31, 2015...
January 19, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29300932/endometrial-stromal-cell-attachment-and-matrix-homeostasis-in-abdominal-wall-endometriomas
#6
Hiroko Itoh, Haruta Mogami, Laurice Bou Nemer, Larry Word, David Rogers, Rodney Miller, R Ann Word
STUDY QUESTION: How does progesterone alter matrix remodeling in abdominal wall endometriomas compared with normal endometrium? SUMMARY ANSWER: Progesterone may prevent attachment of endometrial cells to the abdominal wall, but does not ameliorate abnormal stromal cell responses of abdominal wall endometriomas. WHAT IS KNOWN ALREADY: Menstruation is a tightly orchestrated physiologic event in which steroid hormones and inflammatory cells cooperatively initiate shedding of the endometrium...
December 28, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29277083/manipulation-under-anaesthesia-and-steroid-injection-for-pain-and-stiffness-after-surgery-to-the-first-metatarsophalangeal-joint
#7
Sanil Ajwani, Cezary Kocialkowski, Rebecca Hill, Nasser Kurdy
AIM: To determine the effectiveness of manipulation under anaesthesia and local steroid injection to treat stiffness of the first metatarsophalangeal joint following surgery for hallux rigidus or hallux valgus. METHODS: Patients were identified who had undergone surgery for hallux rigidus or hallux valgus and subsequently were treated with manipulation and steroid injection for stiffness of their joint. Patient records were reviewed to determine the range of movement of the joint pre-operatively, immediately following the procedure and at subsequent follow up...
November 22, 2017: Foot
https://www.readbyqxmd.com/read/29248734/eosinophilic-esophagitis-reference-score-accurately-identifies-disease-activity-and-treatment-effects-in-children
#8
J B Wechsler, S Bolton, K Amsden, B K Wershil, I Hirano, A F Kagalwalla
BACKGROUND & AIMS: The endoscopic reference score (EREFS) is used to determine severity of 5 endoscopic findings: edema, rings, exudates, furrows, and strictures. Little is known about the relationship between EREFSs and histologic markers of disease activity in children with eosinophilic esophagitis (EoE). We aimed to determine whether the EREFS can be used to identify children with EoE and how it changes with treatment. METHODS: We performed a prospective study of consecutive children (ages 2-17 years) undergoing diagnostic or post-treatment endoscopy scored real-time with EREFS from December 2012 through 2016...
December 14, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29244084/the-value-of-peri-operative-levels-of-acth-dhea-and-dhea-s-and-tumor-size-in-predicting-recurrence-of-cushing-s-disease
#9
Nadine El Asmar, Aman Rajpal, Warren R Selman, Baha M Arafah
Background and Objectives: Despite the development of hypocortisolemia after corticotroph surgical adenomectomy, 15-20% patients have recurrence of Cushing's disease (CD). In this study, we investigated the impact of tumor size and the value of peri-operative assessment of ACTH and adrenal steroid levels in predicting recurrence. Methods: Peri-operatively, no glucocorticoids were administered until the serum cortisol was ≤ 3 ug/dL. Blood samples were obtained before and repeatedly after adenomectomy in 79 patients with CD...
December 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29234732/endovascular-aneurysm-repair-evar-of-an-infrarenal-abdominal-aortic-aneurysm-aaa-in-a-young-patient-with-systemic-lupus-erythematosus-sle
#10
Nick Z P Ng, Tze Tec Chong
Introduction: While hypertension, pericardial, myocardial, and coronary artery disease are common cardiovascular manifestations of systemic lupus erythematosus (SLE), aortic aneurysms (AA) are rare but increasingly diagnosed, with the true incidence unknown. Case report: A 40 year old female suffering from SLE with a 5.3 cm saccular eccentric infrarenal abdominal aortic aneurysm (AAA) was treated successfully with endovascular aneurysm repair (EVAR) using the Medtronic Endurant II bifurcated stent graft and followed up 2 years post-operatively...
2017: EJVES Short Reports
https://www.readbyqxmd.com/read/29188366/pre-operative-neutrophil-count-and-neutrophil-lymphocyte-count-ratio-nlcr-in-predicting-the-histological-grade-of-paediatric-brain-tumours-a-preliminary-study
#11
J R F Wilson, F Saeed, A K Tyagi, J R Goodden, G Sivakumar, D Crimmins, M Elliott, S Picton, P D Chumas
INTRODUCTION: The neutrophil-lymphocyte count ratio (NLCR) is an established prognostic marker for renal, lung and colorectal carcinomas and has been suggested to be predictive of histological grade and outcome in adult intracranial tumours. The purpose of this study was to determine whether a correlation of the pre-operative neutrophil count (NC) and NLCR with the final histological grade exists in paediatric intracranial tumours. METHODS: A retrospective analysis was undertaken at a single centre...
November 29, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29153256/intraoperative-force-and-electrocochleography-measurements-in-an-animal-model-of-cochlear-implantation
#12
J Lo, C Bester, A Collins, C Newbold, A Hampson, S Chambers, H Eastwood, S O'Leary
To preserve residual hearing, techniques for monitoring and reducing the effects of trauma during cochlear implant surgery are being developed. This study examines the relationships between intraoperative recordings (electrode insertion force and electrocochleography), trauma, and hearing loss after cochlear implantation. The study also evaluated the efficacy of intravenous steroids for reducing hearing loss after implantation. Thirty-two normal-hearing guinea pigs were randomly implanted with electrode arrays of differing stiffness ('hard' or 'soft')...
November 9, 2017: Hearing Research
https://www.readbyqxmd.com/read/29123632/management-of-post-endodontic-retreatment-pain-with-low-level-laser-therapy
#13
Mohammad Asnaashari, Hengameh Ashraf, Amir Houshang Daghayeghi, Seyed Masoud Mojahedi, Saranaz Azari-Marhabi
Introduction: Pharmacotherapy with analgesics and non-steroidal anti-inflammatory drugs has been traditionally used to relief post-operative pain of endodontic treatments. However, due to the side effects reported for these drugs, some efforts have been made to decrease the post-operative pain of the endodontic treatments through laser irradiation. The present study aimed to evaluate the effects of low level laser therapy (LLLT) on the reduction of pain after root canal retreatment. Methods: In this clinical trial, 61 patients requiring endodontic retreatments in posterior teeth were selected...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29102751/epidural-steroids-at-closure-post-microdiscectomy-laminectomy-for-reduction-of-post-operative-analgesia-systematic-review-and-meta-analysis
#14
Ash Wilson-Smith, Nicholas Chang, Victor M Lu, Ralph J Mobbs, Matthew Fadhil, Declan Lloyd, Sara Kim, Kevin Phan
BACKGROUND: This review assessed the efficacy of epidural steroid administration on the reduction of pain, hospital stay time and use of opioid analgesics postoperatively. METHODS: We searched Medline, PubMed, Embase, Cochrane Central Register of Controlled Trials (CCRCT) and Cochrane Database of Systematic Reviews (CDSR) for studies utilizing epidural steroids through any route following lumbar surgery. The primary study outcomes included pre- and postoperative pain as assessed through the use of a Visual Analogue Scale (VAS), length of hospital stay and postoperative use of opioid analgesics...
November 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29100944/regulatory-dendritic-cells-for-promotion-of-liver-transplant-operational-tolerance-rationale-for-a-clinical-trial-and-accompanying-mechanistic-studies
#15
REVIEW
Angus W Thomson, Abhinav Humar, Fadi G Lakkis, Diana M Metes
Dendritic cells (DC) are rare, bone marrow (BM)-derived innate immune cells that critically maintain self-tolerance in the healthy steady-state. Regulatory DC (DCreg) with capacity to suppress allograft rejection and promote transplant tolerance in pre-clinical models can readily be generated from BM precursors or circulating blood monocytes. These DCreg enhance allograft survival via various mechanisms, including promotion of regulatory T cells. In non-human primates receiving minimal immunosuppressive drug therapy (IS), infusion of DCreg of donor origin, one week before transplant, safely prolongs renal allograft survival and selectively attenuates anti-donor CD8(+) memory T cell responses in the early post-transplant period...
October 31, 2017: Human Immunology
https://www.readbyqxmd.com/read/28913997/additive-effect-of-oral-steroid-with-topical-nonsteroidal-anti-inflammatory-drug-for-preventing-cystoid-macular-edema-after-cataract-surgery-in-patients-with-epiretinal-membrane
#16
COMPARATIVE STUDY
Seonghwan Kim, Mee Kum Kim, Won Ryang Wee
PURPOSE: To investigate the additive effect of oral steroid with topical nonsteroidal anti-inflammatory drug (NSAID) on cystoid macular edema (CME) in patients with epiretinal membrane (ERM) after cataract surgery. METHODS: Medical records of subjects who underwent uneventful cataract surgery (n = 1,349) were retrospectively reviewed; among these patients, those with pre-existing ERM (n = 81) were included. Patients were divided into two groups: one group had postoperative administration of oral steroid for 1 week (n = 45) and the other group did not have oral steroid administration (n = 36)...
October 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28883084/advances-in-risk-oriented-surgery-for-multiple-endocrine-neoplasia-type-2
#17
Andreas Machens, Henning Dralle
Genetic association studies hinge on definite clinical case definitions of the disease of interest. This is why more penetrant mutations were overrepresented in early multiple endocrine neoplasia 2 (MEN2) studies, whereas less penetrant mutations went underrepresented. Enrichment of genetic association studies with advanced disease may produce a flawed understanding of disease evolution, precipitating far-reaching surgical strategies like bilateral total adrenalectomy and 4-gland parathyroidectomy in MEN2. The insight into the natural course of the disease gleaned over the past 25 years caused a paradigm shift in MEN2: from the removal of target organs at the expense of greater operative morbidity to close biochemical surveillance and targeted resection of adrenal tumors and hyperplastic parathyroid glands...
September 7, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28839403/evaluation-of-oral-pentoxifylline-in-the-management-of-oral-submucous-fibrosis-an-ultrasonographic-study
#18
Jayachandran Sadaksharam, Sureshkumar Mahalingam
AIM AND OBJECTIVE: To evaluate the therapeutic efficacy of oral pentoxifylline in the treatment of oral submucous fibrosis (OSMF) patients by assessing the clinical symptoms such as burning sensation, mouth opening, and submucosal layer thickness and echogenicity using ultrasonography, both pre- and post-operatively. MATERIALS AND METHODS: Thirty study subjects were included in the study and divided into two groups in single-blind randomized manner, oral pentoxifylline and dexamethasone group...
April 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/28836877/management-of-hyperglycemia-in-the-neurosurgery-patient
#19
REVIEW
Rene Daniel, Satya Villuri, Kevin Furlong
Hyperglycemia is associated with adverse outcomes in patients who are candidates for or underwent neurosurgical procedures. Specific concerns and settings that relate to these patients are preoperative glycemic control, intraoperative control, management in the neurological intensive care unit (NICU), and postoperative control. In each of these settings, physicians have to ensure appropriate glycemic control to prevent or minimize adverse events. The glycemic control is usually managed by a neurohospitalist in co-management with the neurosurgery team pre- and post-operatively, and by the neurocritical care team in the setting of NICU...
October 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/28810599/effects-of-niflumic-acid-on-%C3%AE-aminobutyric-acid-induced-currents-in-isolated-dorsal-root-ganglion-neurons-of-neuropathic-pain-rats
#20
Li-Jie Wang, Yang Wang, Meng-Jie Chen, Zhen-Pu Tian, Bi-Han Lu, Ke-Tao Mao, Liang Zhang, Lei Zhao, Li-Ya Shan, Li Li, Jun-Qiang Si
Niflumic acid (NFA) is a type of non-steroidal anti-inflammatory drug. Neuropathic pain is caused by a decrease in presynaptic inhibition mediated by γ-aminobutyric acid (GABA). In the present study, a whole-cell patch-clamp technique and intracellular recording were used to assess the effect of NFA on GABA-induced inward current in dorsal root ganglion (DRG) neurons of a chronic constriction injury (CCI) model. It was observed that 1-1,000 µmol/l GABA induced a concentration-dependent inward current in DRG neurons...
August 2017: Experimental and Therapeutic Medicine
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