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Lung biopsy

Manon Kolb, Salim Chucri, Beatrice Duxbury, Dan Adler, Jean-Claude Pache, Paola M Soccal, Jérôme Plojoux
The diagnosis of interstitial lung disease (ILD) is challenging and relies on a multidisciplinary discussion involving clinical, radiological and sometimes histological features. Bronchoscopic lung cryobiopsies have emerged as a new minimally invasive method of lung sampling and an alternative to surgical lung biopsies. A good diagnostic performance and excellent safety profile make it an interesting and worthful procedure which could decrease the number of patients without proper diagnosis and treatment. There is a need for further studies to standardize the technique in expert centers and to establish its role in the diagnostic work-up of ILD...
November 14, 2018: Revue Médicale Suisse
Alice Lallo, Sakshi Gulati, Maximilian W Schenk, Garima Khandelwal, Ulrika Warpman Berglund, Ioannis S Pateras, Christopher P E Chester, Therese M Pham, Christina Kalderen, Kristopher K Frese, Vassilis G Gorgoulis, Crispin Miller, Fiona Blackhall, Thomas Helleday, Caroline Dive
BACKGROUND AND PURPOSE: Small cell lung cancer (SCLC) is an aggressive disease with median survival of < 2 years. Tumour biopsies for research are scarce, especially from extensive-stage patients, with repeat sampling at disease progression rarely performed. We overcame this limitation for relevant preclinical models by developing SCLC circulating tumour cell derived explants (CDX) which mimic the donor tumour pathology and chemotherapy response. To facilitate compound screening and identification of clinically relevant biomarkers, we developed short term ex vivo cultures of CDX tumour cells...
November 14, 2018: British Journal of Pharmacology
Chung-Feng Huang, Ming-Lun Yeh, Ching-I Huang, Po-Cheng Liang, Yi-Hung Lin, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Ming-Lung Yu
BACKGROUND/AIMS: Liver fibrosis determined hepatocellular carcinoma (HCC) occurrence in chronic hepatitis C patients with sustained virological response (SVR). We aimed to determine whether post-treatment fibrotic modification overwhelmed pretreatment fibrotic status in terms of long-term HCC prediction. METHODS: 265 SVR patients with paired biopsies before and after antiviral therapy were enrolled for analysis of the association of fibrotic changes with HCC. RESULTS: Eighteen (6...
November 13, 2018: Hepatology International
Mehdi Khorshidi, Sepehr Navid, Davood Azadi, Darioush Shokri, Hasan Shojaei
Introduction: Nocardia are Gram-positive partially acid-fast bacilli capable of inducing a wide range of infections in patients with immunodeficiency, AIDS, cancer, lupus erythematous and diabetes. Nocardia cyriacigeorgica was first isolated in 2001 from a patient with chronic bronchitis. Since then, there have been reports on the clinical significance of this organism in patients with bronchitis, brain abscess and lung diseases. We, herein, report a case of brain abscess in an elderly diabetic patient from Iran...
September 2018: JMM Case Reports
Minji Lim, Chi-Ju Kim, Vijaya Sunkara, Mi-Hyun Kim, Yoon-Kyoung Cho
Lung cancer is by far the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) accounting for the majority of cases. Recent advances in the understanding of the biology of tumors and in highly sensitive detection technologies for molecular analysis offer targeted therapies, such as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. However, our understanding of an individual patient's lung cancer is often limited by tumor accessibility because of the high risk and invasive nature of current tissue biopsy procedures...
February 28, 2018: Micromachines
N F Wang, Y Yang, S F Chen
No abstract text is available yet for this article.
November 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
P Yuan, C Y Guo, Y Li, L L Jiang, Y P Liu, X Y Liu, J M Ying
Objective: To analyze the expression of programmed death ligand 1 (PD-L1) in patients with advanced lung adenocarcinoma and the consistency of four PD-L1 immunohistochemical detection platforms, with an aim of establishing baseline information to predict and select patients for programmed death 1 (PD-1)/PD-L1 immune inhibitor therapy. Methods: This was a multi-center retrospective study, collecting totally 57 advanced lung adenocarcinoma biopsy specimens from four centers from August 2017 to December 2017.The mean age of 57 patients was 59 (range 34-81) years, and 29 cases were male, 28 cases were female...
November 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Israel Fernandez-Pineda, Aaron D Seims, Lisa VanHouwelingen, Hafeez Abdelhafeez, Huiyun Wu, Jianrong Wu, Andrew J Murphy, Andrew M Davidoff
BACKGROUND: Uniportal video-assisted thoracic surgery (VATS) is gaining popularity among thoracic surgeons, but the limited space in the thorax of children makes uniportal VATS difficult to perform. The purpose of this study was to evaluate procedural and outcome differences between a modified uniportal VATS (MU-VATS) and three-port VATS (TP-VATS) for peripheral lung nodule biopsy in pediatric cancer patients. MATERIALS AND METHODS: This is an Institutional Review Board-approved retrospective analysis of all consecutive MU-VATS and TP-VATS peripheral lung nodule biopsies performed at a single institution between June 2014 and December 2016...
November 10, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Qinghua Zhou, Jingsi Dong, Jie He, Deruo Liu, David H Tian, Shugeng Gao, Shanqing Li, Lunxu Liu, Jianxing He, Yunchao Huang, Shidong Xu, Weimin Mao, Qunyou Tan, Chun Chen, Xiaofei Li, Zhu Zhang, Gening Jiang, Lin Xu, Lanjun Zhang, Jianhua Fu, Hui Li, Qun Wang, Lijie Tan, Danqing Li, Qinghua Zhou, Xiangning Fu, Zhongmin Jiang, Haiquan Chen, Wentao Fang, Xun Zhang, Yin Li, Ti Tong, Zhentao Yu, Yongyu Liu, Xiuyi Zhi, Tiansheng Yan, Xingyi Zhang, Roberto F Casal, Eugenio Pompeo, Angelo Carretta, Marc Riquet, Ottavio Rena, Pierre-Emmanuel Falcoz, Hisashi Saji, Ali Zamir Khan, Jose Luis Danguilan, Diego Gonzalez-Rivas, Nicolas Guibert, Chengchu Zhu, Jianfei Shen
No abstract text is available yet for this article.
September 2018: Journal of Thoracic Disease
Ian C Bostock, Fariha Sheikh, Timothy M Millington, David J Finley, Joseph D Phillips
Background: Surgery plays an important role in the management of complex thoracic infections (CTIs). We aimed to describe the contemporary surgical outcomes of CTIs. Methods: The 2014-2017 National Surgical Quality Improvement Program (NSQIP) database was queried for patients with the following procedures: bilobectomy, decortication, lung release, lobectomy, thoracoscopic lobectomy, thoracoscopic pleurodesis, thoracoscopic wedge resection, thoracoscopic biopsy, thoracoscopy, thoracotomy, thoracotomy with wedge resection, thoracotomy with decortication, and thoracotomy with lobectomy...
September 2018: Journal of Thoracic Disease
Min Joo Kim, Han Na Lee, Jung Im Kim, Gou Young Kim
Pulmonary pleomorphic carcinoma is defined as a nonsmall cell lung carcinoma (NSCLC) that contains at least 10% sarcomatoid components. We report a case of pulmonary pleomorphic carcinoma of which only the sarcomatoid component metastasized to the small bowel and adenocarcinoma was identified on percutaneous transthoracic needle biopsy (PTNB). We suggest that if an NSCLC is diagnosed by PTNB and a sarcoma is found at another site, or vice versa, pulmonary pleomorphic carcinoma with a single metastasis should be considered as a differential diagnosis to establish the best effective treatment plan...
October 2018: Annals of Thoracic Medicine
Xiang Wang, Yun-Xia Tao, Miao Zhang, Wen-Bin Wu, Dun-Peng Yang, Min Wang
RATIONALE: Asymptomatic, isolated, and thin-walled cystic lung cancer with extensive extrapulmonary metastasis is rare, and the risk of pulmonary cyst developing into lung cancer is poorly understood. The efficacy of apatinib for end-stage pulmonary adenosquamous carcinoma has not been clarified yet. PATIENT CONCERNS: We herein report a rare case of primary lung cancer that appeared as an isolated thin-walled cystic lesion on computed tomography (CT) image, who was initially misdiagnosed as having pulmonary cyst empirically...
October 2018: Medicine (Baltimore)
Giridhar M Shivaram, Anne Elizabeth Gill, Eric J Monroe, Kevin S H Koo, C Matthew Hawkins
BACKGROUND: Cone-beam CT is increasingly used in pediatric interventional radiology procedures. However, the feasibility or safety of using this mode of imaging guidance for percutaneous lung nodule biopsy in children has not been assessed. OBJECTIVE: To retrospectively evaluate safety and diagnostic accuracy of percutaneous lung nodule biopsy in people treated at a pediatric hospital using cone-beam CT with navigational overlay. MATERIALS AND METHODS: Thirty-six consecutive patients from two large tertiary-care children's hospitals with lung nodules of 48 mm or smaller underwent percutaneous lung nodule biopsy using cone-beam CT with navigational overlay...
November 8, 2018: Pediatric Radiology
Blanca De Vega Sánchez, Rafael López Castro
An 83-year-old male who was a former smoker had pain on the left forearm accompanied with progressive swallowing in the last four to five months. Imaging studies revealed a cystic necrotic mass on the flexor digitorum superficialis muscle (biopsy: striated muscle tissue infiltrated by an adenocarcinoma). A whole-body computerized tomography (CT) scan demonstrates the presence of two lung masses that were suspicious of malignancy. Diagnosed as having stage IV lung adenocarcinoma (cT4NxM1b, IASLC TNM 8th [3]), he received chemotherapy with a carboplatin/pemetrexed-based regimen and local palliative radiation for the control of arm pain...
November 29, 2017: Turkish Thoracic Journal
Susan E Fielder, James H Meinkoth, Theresa E Rizzi, Andrew S Hanzlicek, Ruth Mackenzie Hallman
OBJECTIVES: The aim of this study was to describe clinical and diagnostic findings in cats with bone and joint disease associated with histoplasmosis. METHODS: Medical records from between 2011 and 2017 were reviewed. Inclusion criteria required: (1) diagnosis of histoplasmosis by cytology, histology, urine or serum Histoplasma antigen testing, or culture; and (2) lameness or joint effusion as a presenting complaint or physical examination finding. RESULTS: Twenty-five cases met the inclusion criteria...
November 8, 2018: Journal of Feline Medicine and Surgery
Christine S Shusted, Julie A Barta, Michael Lake, Rickie Brawer, Brooke Ruane, Teresa E Giamboy, Baskaran Sundaram, Nathaniel R Evans, Ronald E Myers, Gregory C Kane
Patient navigation has been proposed to combat cancer disparities in vulnerable populations. Vulnerable populations often have poorer cancer outcomes and lower levels of screening, adherence, and treatment. Navigation has been studied in various cancers, but few studies have assessed navigation in lung cancer. Additionally, there is a lack of consistency in metrics to assess the quality of navigation programs. The authors conducted a systematic review of published cancer screening studies to identify quality metrics used in navigation programs, as well as to recommend standardized metrics to define excellence in lung cancer navigation...
November 8, 2018: Population Health Management
Theun de Groot, Ferry Hagen, Willem Vreuls, Paul E Verweij, Anuradha Chowdhary, Jacques F Meis
Invasive aspergillosis (IA) is a deep tissue infection with a high mortality occurring mostly in immunocompromised patients. To investigate the pathology of patients with IA it may be important to determine the genotype of the invasive isolate of Aspergillus , however available tissues for study are often formalin fixed paraffin embedded (FFPE). Although DNA has been successfully isolated from such tissues for species identification, genotyping of Aspergillus species on such tissues has not yet been performed...
2018: Frontiers in Cellular and Infection Microbiology
A N Niemeijer, D Leung, M C Huisman, I Bahce, O S Hoekstra, G A M S van Dongen, R Boellaard, S Du, W Hayes, R Smith, A D Windhorst, N H Hendrikse, A Poot, D J Vugts, E Thunnissen, P Morin, D Lipovsek, D J Donnelly, S J Bonacorsi, L M Velasquez, T D de Gruijl, E F Smit, A J de Langen
PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions.
November 7, 2018: Nature Communications
Mouhamad Nasser, Vincent Cottin
Defined by the accumulation of red blood cells into the alveolar space, diffuse alveolar hemorrhage (DAH) is a severe and potentially fatal medical condition requiring careful attention. In contrast to simple extravasation of erythrocytes facilitated by impaired hemostasis or hemodynamic causes, DAH in vasculitis is due to capillaritis, that is, inflammation of capillaries. Dyspnea, hemoptysis, chest infiltrates, and abrupt fall of blood hemoglobin level represent the cardinal features of DAH; yet, hemoptysis is lacking in one-third of cases...
August 2018: Seminars in Respiratory and Critical Care Medicine
Wonchul Lee, Se Young Choi, Chanwoo Lee, Sangjun Yoo, Dalsan You, In Gab Jeong, Cheryn Song, Kun Suk Kim, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
Purpose: Classic angiomyolipoma (AML) is common benign kidney tumor. However, some studies have claimed that epithelioid angiomyolipoma (EAML) has malignant potential. We compared the patient characteristics and prognosis of EAML and classic AML to demonstrate predicting factors and poorer prognosis of EAML. Materials and Methods: The medical records of 231 patients who were diagnosed with EAML (n=27, 11.7%) or classic AML (n=204, 88.3%), were reviewed. All patients underwent computed tomography (CT) scans before operation or needle biopsy...
November 2018: Investigative and Clinical Urology
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