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https://www.readbyqxmd.com/read/28102913/autumn-photosynthetic-decline-and-growth-cessation-in-seedlings-of-white-spruce-are-decoupled-under-warming-and-photoperiod-manipulations
#1
Joseph R Stinziano, Danielle A Way
Climate warming is expected to increase the seasonal duration of photosynthetic carbon fixation and tree growth in high latitude forests. However photoperiod, a crucial cue for seasonality, will remain constant, which may constrain tree responses to warming. We investigated the effects of temperature and photoperiod on weekly changes in photosynthetic capacity, leaf biochemistry and growth in seedlings of a boreal evergreen conifer, white spruce (Picea glauca (Moench) Voss). Warming delayed autumn declines in photosynthetic capacity, extending the period when seedlings had high carbon uptake...
January 19, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28102329/leads-in-arctic-pack-ice-enable-early-phytoplankton-blooms-below-snow-covered-sea-ice
#2
Philipp Assmy, Mar Fernández-Méndez, Pedro Duarte, Amelie Meyer, Achim Randelhoff, Christopher J Mundy, Lasse M Olsen, Hanna M Kauko, Allison Bailey, Melissa Chierici, Lana Cohen, Anthony P Doulgeris, Jens K Ehn, Agneta Fransson, Sebastian Gerland, Haakon Hop, Stephen R Hudson, Nick Hughes, Polona Itkin, Geir Johnsen, Jennifer A King, Boris P Koch, Zoe Koenig, Slawomir Kwasniewski, Samuel R Laney, Marcel Nicolaus, Alexey K Pavlov, Christopher M Polashenski, Christine Provost, Anja Rösel, Marthe Sandbu, Gunnar Spreen, Lars H Smedsrud, Arild Sundfjord, Torbjørn Taskjelle, Agnieszka Tatarek, Jozef Wiktor, Penelope M Wagner, Anette Wold, Harald Steen, Mats A Granskog
The Arctic icescape is rapidly transforming from a thicker multiyear ice cover to a thinner and largely seasonal first-year ice cover with significant consequences for Arctic primary production. One critical challenge is to understand how productivity will change within the next decades. Recent studies have reported extensive phytoplankton blooms beneath ponded sea ice during summer, indicating that satellite-based Arctic annual primary production estimates may be significantly underestimated. Here we present a unique time-series of a phytoplankton spring bloom observed beneath snow-covered Arctic pack ice...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101520/an-observational-study-of-alemtuzumab-following-fingolimod-for-multiple-sclerosis
#3
Mark Willis, Owen Pearson, Zsolt Illes, Tobias Sejbaek, Christian Nielsen, Martin Duddy, Kate Petheram, Caspar van Munster, Joep Killestein, Clas Malmeström, Emma Tallantyre, Neil Robertson
OBJECTIVE: To describe a series of patients with relapsing multiple sclerosis (MS) who experienced significant and unexpected disease activity within the first 12 months after switching from fingolimod to alemtuzumab. METHODS: Patients with relapsing MS treated sequentially with fingolimod then alemtuzumab who experienced significant subsequent disease activity were identified by personal communication with 6 different European neuroscience centers. RESULTS: Nine patients were identified...
March 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28101231/the-biological-significance-of-methylome-differences-in-human-papilloma-virus-associated-head-and-neck-cancer
#4
Maria J Worsham, Kang Mei Chen, Indrani Datta, Josena K Stephen, Dhananjay Chitale, Alexandra Gothard, George Divine
In recent years, studies have suggested that promoter methylation in human papilloma virus (HPV) positive head and neck squamous cell carcinoma (HNSCC) has a mechanistic role and has the potential to improve patient survival. The present study aimed to replicate key molecular findings from previous analyses of the methylomes of HPV positive and HPV negative HNSCC in an independent cohort, to assess the reliability of differentially methylated markers in HPV-associated tumors. HPV was measured using real-time quantitative PCR and the biological significance of methylation differences was assessed by Ingenuity Pathway Analysis (IPA)...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28100513/loss-of-ranbp2-in-motor-neurons-causes-the-disruption-of-nucleocytoplasmic-and-chemokine-signaling-and-proteostasis-of-hnrnph3-and-mmp28-and-the-development-of-amyotrophic-lateral-sclerosis-als-like-syndromes
#5
Kyoung-In Cho, Dosuk Yoon, Sunny Qiu, Zachary Danziger, Warren M Grill, William C Wetsel, Paulo A Ferreira
The pathogenic drivers of sporadic and familial motor neuron disease (MND), such ALS, are unknown. MND impair the Ran GTPase cycle, which controls nucleocytoplasmic transport, ribostasis and proteostasis; however, cause-effect mechanisms of Ran GTPase modulators in motoneuron pathobiology are heretofore elusive. The cytosolic and peripheral nucleoporin, Ranbp2, is a critical regulator of the Ran GTPase cycle and proteostasis of neurological disease-prone substrates, but the roles of Ranbp2 in motoneuron biology and disease remain unknown...
January 18, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28098236/wind-wave-behavior-in-fetch-and-depth-limited-estuaries
#6
Arash Karimpour, Qin Chen, Robert R Twilley
Wetland dominated estuaries serve as one of the most productive natural ecosystems through their ecological, economic and cultural services, such as nursery grounds for fisheries, nutrient sequestration, and ecotourism. The ongoing deterioration of wetland ecosystems in many shallow estuaries raises concerns about the contributing erosive processes and their roles in restraining coastal restoration efforts. Given the combination of wetlands and shallow bays as landscape components that determine the function of estuaries, successful restoration strategies require knowledge of wind wave behavior in fetch and depth limited water as a critical design feature...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097216/the-last-frontiers-of-wilderness-tracking-loss-of-intact-forest-landscapes-from-2000-to-2013
#7
Peter Potapov, Matthew C Hansen, Lars Laestadius, Svetlana Turubanova, Alexey Yaroshenko, Christoph Thies, Wynet Smith, Ilona Zhuravleva, Anna Komarova, Susan Minnemeyer, Elena Esipova
An intact forest landscape (IFL) is a seamless mosaic of forest and naturally treeless ecosystems with no remotely detected signs of human activity and a minimum area of 500 km(2). IFLs are critical for stabilizing terrestrial carbon storage, harboring biodiversity, regulating hydrological regimes, and providing other ecosystem functions. Although the remaining IFLs comprise only 20% of tropical forest area, they account for 40% of the total aboveground tropical forest carbon. We show that global IFL extent has been reduced by 7...
January 2017: Science Advances
https://www.readbyqxmd.com/read/28096329/tissue-dual-rna-seq-allows-fast-discovery-of-infection-specific-functions-and-riboregulators-shaping-host-pathogen-transcriptomes
#8
Aaron M Nuss, Michael Beckstette, Maria Pimenova, Carina Schmühl, Wiebke Opitz, Fabio Pisano, Ann Kathrin Heroven, Petra Dersch
Pathogenic bacteria need to rapidly adjust their virulence and fitness program to prevent eradication by the host. So far, underlying adaptation processes that drive pathogenesis have mostly been studied in vitro, neglecting the true complexity of host-induced stimuli acting on the invading pathogen. In this study, we developed an unbiased experimental approach that allows simultaneous monitoring of genome-wide infection-linked transcriptional alterations of the host and colonizing extracellular pathogens. Using this tool for Yersinia pseudotuberculosis-infected lymphatic tissues, we revealed numerous alterations of host transcripts associated with inflammatory and acute-phase responses, coagulative activities, and transition metal ion sequestration, highlighting that the immune response is dominated by infiltrating neutrophils and elicits a mixed TH17/TH1 response...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095992/changes-in-ecosystem-carbon-pool-and-soil-co2-flux-following-post-mine-reclamation-in-dry-tropical-environment-india
#9
Jitendra Ahirwal, Subodh Kumar Maiti, Ashok Kumar Singh
Open strip mining of coal results in loss of natural carbon (C) sink and increased emission of CO2 into the atmosphere. A field study was carried out at five revegetated coal mine lands (7, 8, 9, 10 and 11years) to assess the impact of the reclamation on soil properties, accretion of soil organic C (SOC) and nitrogen (N) stock, changes in ecosystem C pool and soil CO2 flux. We estimated the presence of C in the tree biomass, soils, litter and microbial biomass to determine the total C sequestration potential of the post mining reclaimed land...
January 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28094300/sequestration-of-prmt1-and-nd1-l-mrna-into-als-linked-fus-mutant-r521c-positive-aggregates-contributes-to-neurite-degeneration-upon-oxidative-stress
#10
Mi-Hee Jun, Hyun-Hee Ryu, Yong-Woo Jun, Tongtong Liu, Yan Li, Chae-Seok Lim, Yong-Seok Lee, Bong-Kiun Kaang, Deok-Jin Jang, Jin-A Lee
Mutations in fused in sarcoma (FUS), a DNA/RNA binding protein, are associated with familial amyotrophic lateral sclerosis (ALS). However, little is known about how ALS-causing mutations alter protein-protein and protein-RNA complexes and contribute to neurodegeneration. In this study, we identified protein arginine methyltransferase 1 (PRMT1) as a protein that more avidly associates with ALS-linked FUS-R521C than with FUS-WT (wild type) or FUS-P525L using co-immunoprecipitation and LC-MS analysis. Abnormal association between FUS-R521C and PRMT1 requires RNA, but not methyltransferase activity...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093297/bottom-up-synthesis-of-carbon-nanoparticles-with-higher-doxorubicin-efficacy
#11
Samer Bayda, Mohamad Hadla, Stefano Palazzolo, Vinit Kumar, Isabella Caligiuri, Emmanuele Ambrosi, Enrico Pontoglio, Marco Agostini, Tiziano Tuccinardi, Alvise Benedetti, Pietro Riello, Vincenzo Canzonieri, Giuseppe Corona, Giuseppe Toffoli, Flavio Rizzolio
Nanomedicine requires intelligent and non-toxic nanomaterials for real clinical applications. Carbon materials possess interesting properties but with some limitations due to toxic effects. Interest in carbon nanoparticles (CNPs) is increasing because they are considered green materials with tunable optical properties, overcoming the problem of toxicity associated with quantum dots or nanocrystals, and can be utilized as smart drug delivery systems. Using black tea as a raw material, we synthesized CNPs with a narrow size distribution, tunable optical properties covering visible to deep red absorption, non-toxicity and easy synthesis for large-scale production...
January 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28092748/optimizing-selective-cutting-strategies-for-maximum-carbon-stocks-and-yield-of-moso-bamboo-forest-using-biome-bgc-model
#12
Fangjie Mao, Guomo Zhou, Pingheng Li, Huaqiang Du, Xiaojun Xu, Yongjun Shi, Lufeng Mo, Yufeng Zhou, Guoqing Tu
The selective cutting method currently used in Moso bamboo forests has resulted in a reduction of stand productivity and carbon sequestration capacity. Given the time and labor expense involved in addressing this problem manually, simulation using an ecosystem model is the most suitable approach. The BIOME-BGC model was improved to suit managed Moso bamboo forests, which was adapted to include age structure, specific ecological processes and management measures of Moso bamboo forest. A field selective cutting experiment was done in nine plots with three cutting intensities (high-intensity, moderate-intensity and low-intensity) during 2010-2013, and biomass of these plots was measured for model validation...
January 13, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28087527/floc-formation-reduces-the-ph-stress-experienced-by-microorganisms-living-in-alkaline-environments
#13
C J Charles, S P Rout, K A Patel, S Akbar, A P Laws, B R Jackson, S A Boxall, P N Humphreys
: The survival of microorganisms within a cementitious geological disposal facility for radioactive wastes is heavily dependent on their ability to survive the calcium dominated, hyper-alkaline conditions resulting from the dissolution of the cementitious materials. The present study shows that the formation of flocs, composed of a complex mixture of extracellular polymeric substances (EPS), provides protection against alkaline pH values up to pH 13.0. The flocs were dominated by Alishewanella and Dietzia sp, producing a mannose rich carbohydrate fraction incorporating extracellular DNA, resulting in Ca(2+) sequestration...
January 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28081568/non-lethal-endotoxin-injection-a-rat-model-of-hypercoagulability
#14
Marjory B Brooks, James R Turk, Abraham Guerrero, Padma K Narayanan, John P Nolan, Elizabeth G Besteman, Dennis W Wilson, Roberta A Thomas, Cindy E Fishman, Karol L Thompson, Heidrun Ellinger-Ziegelbauer, Jennifer B Pierson, April Paulman, Alan Y Chiang, Albert E Schultze
Systemic inflammation co-activates coagulation, which unchecked culminates in a lethal syndrome of multi-organ microvascular thrombosis known as disseminated intravascular coagulation (DIC). We studied an endotoxin-induced inflammatory state in rats to identify biomarkers of hemostatic imbalance favoring hypercoagulability. Intraperitoneal injection of LPS at 15 mg/kg body weight resulted in peripheral leukopenia and widespread neutrophilic sequestration characteristic of an acute systemic inflammatory response...
2017: PloS One
https://www.readbyqxmd.com/read/28081368/smart-metal-organic-framework-coatings-triggered-anti-biofilm-compound-release
#15
Birgit Claes, Tom Boudewijns, Laurens Muchez, Geert Hooyberghs, Erik V Van der Eycken, Jozef Vanderleyden, Hans P Steenackers, Dirk E De Vos
Metal-organic frameworks (MOFs) have a large potential for delivery of active molecules. Here, a MOF coating is investigated as a smart host matrix for triggered release of anti-biofilm compounds. Besides a coating consisting of the regular Fe-terephthalate MIL-88B(Fe), a new hydrophobic MIL-88B(Fe) coating is synthesized in hydrothermal conditions using palmitic acid as a lattice terminating group. These porous materials are used as a host matrix for the anti-biofilm compound 5-(4-chlorophenyl)-N-(2-isobutyl)-2-aminoimidazole, which has a specific biofilm inhibiting effect at concentrations at which no activity against planktonic cells is detected...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28078478/hypercalcaemia-and-hypocalcaemia-finding-the-balance
#16
REVIEW
Jean-Jacques Body, Daniela Niepel, Giuseppe Tonini
CALCIUM METABOLISM IN CANCER AND HYPERCALCAEMIA OF MALIGNANCY: The balance between bone formation and resorption may be disrupted in patients with cancer, leading either to increased bone resorption, calcium release, and possibly hypercalcaemia, or to increased bone formation, sequestration of calcium, and possibly hypocalcaemia. In adults, hypercalcaemia of malignancy is most common in patients with tumours that produce factors that induce osteoclast activation and enhance bone resorption...
January 12, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28078391/soil-organic-carbon-fractions-and-stocks-respond-to-restoration-measures-in-degraded-lands-by-water-erosion
#17
Xiaodong Nie, Zhongwu Li, Jinquan Huang, Bin Huang, Haibing Xiao, Guangming Zeng
Assessing the degree to which degraded soils can be recovered is essential for evaluating the effects of adopted restoration measures. The objective of this study was to determine the restoration of soil organic carbon under the impact of terracing and reforestation. A small watershed with four typical restored plots (terracing and reforestation (four different local plants)) and two reference plots (slope land with natural forest (carbon-depleted) and abandoned depositional land (carbon-enriched)) in subtropical China was studied...
January 11, 2017: Environmental Management
https://www.readbyqxmd.com/read/28077482/rare-case-of-haemoptysis
#18
Elrasheid Ali Awouda, Ahmed Anwar Elnori, AlaEldin Hassan Ahmed
We report a case of a 39-year-old man who presented with coughing up blood for 5 days. On the day of admission, he coughed up about 300 mL of fresh blood. He mentioned that he has had cough for the past 10 years. On clinical examination, he was afebrile, tachypneic, tahycardic and normotensive. Rest of the physical examination was normal. His oxygen saturation breathing room air was 96%. His full blood count showed haemoglobin 9.3 g/dL. His chest radiograph was reported as normal. CT chest showed a vascular right paracardiac soft tissue density...
January 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28075350/hydroxypyridinone-chelators-from-iron-scavenging-to-radiopharmaceuticals-for-pet-imaging-with-gallium-68
#19
REVIEW
Ruslan Cusnir, Cinzia Imberti, Robert C Hider, Philip J Blower, Michelle T Ma
Derivatives of 3,4-hydroxypyridinones have been extensively studied for in vivo Fe(3+) sequestration. Deferiprone, a 1,2-dimethyl-3,4-hydroxypyridinone, is now routinely used for clinical treatment of iron overload disease. Hexadentate tris(3,4-hydroxypyridinone) ligands (THP) complex Fe(3+) at very low iron concentrations, and their high affinities for oxophilic trivalent metal ions have led to their development for new applications as bifunctional chelators for the positron emitting radiometal, (68)Ga(3+), which is clinically used for molecular imaging in positron emission tomography (PET)...
January 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28074452/hemoptysis-caused-by-pulmonary-sequestration-in-perforated-appendicitis-a-rare-case-report
#20
Dario Tartaglia, Francesca Cascione, Matteo Modesti, Desiree Gianardi, Rosilde Caputo, Christian Galatioto, Massimo Chiarugi
Pulmonary sequestration is a rare and usually asymptomatic congenital anomaly. Optimal management of this condition is still a subject of debate, including superiority of surgical resection or angiographic embolization of the aberrant arterial vessel. Presently described is rare case of a 51-year-old male who presented with hemoptysis related to pulmonary sequestration associated with acute right lower quadrant abdominal pain caused by perforated appendicitis.
November 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
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