keyword
https://read.qxmd.com/read/34960109/energy-metabolism-changes-and-dysregulated-lipid-metabolism-in-postmenopausal-women
#21
REVIEW
Seong-Hee Ko, YunJae Jung
Aging women experience hormonal changes, such as decreased estrogen and increased circulating androgen, due to natural or surgical menopause. These hormonal changes make postmenopausal women vulnerable to body composition changes, muscle loss, and abdominal obesity; with a sedentary lifestyle, these changes affect overall energy expenditure and basal metabolic rate. In addition, fat redistribution due to hormonal changes leads to changes in body shape. In particular, increased bone marrow-derived adipocytes due to estrogen loss contribute to increased visceral fat in postmenopausal women...
December 20, 2021: Nutrients
https://read.qxmd.com/read/34957913/lysosomal-acid-lipase-promotes-endothelial-proliferation-in-cold-activated-adipose-tissue
#22
JOURNAL ARTICLE
Alexander W Fischer, Michelle Y Jaeckstein, Joerg Heeren
Oxidative tissues such as brown adipose tissue and muscle internalize large amounts of circulating lipids and glucose as energy source. Endothelial cells (ECs) provide a platform for regulated transport and processing of blood-borne nutrients. Next to this role, it has become recognized that intercellular crosstalk between ECs and underlying parenchymal cells is indispensable for maintenance of tissue homoeostasis. Here, we comment on our recent observation that capillary ECs in thermogenic adipose tissues take up and metabolize entire triglyceride-rich lipoprotein (TRL) particles in response to cold exposure...
December 2022: Adipocyte
https://read.qxmd.com/read/34903775/nutrient-metabolism-in-the-liver-and-muscle-of-juvenile-blunt-snout-bream-megalobrama-amblycephala-in-response-to-dietary-methionine-levels
#23
JOURNAL ARTICLE
Ke Ji, Hualiang Liang, Mingchun Ren, Xianping Ge, Liangkun Pan, Heng Yu
A 75-day rearing trial was designed to study the response of juvenile Megalobrama amblycephala to dietary methionine (Met) levels. Three practical diets with graded Met levels (0.40%, 0.84% and 1.28% dry matter) were prepared to feed the juvenile fish. The results showed that the 0.84% Met diet significantly improved the growth compared with 0.40% diets. Compared with 0.84% and 1.28% Met, 0.40% Met significantly increased the hepatic lipid content, while decreasing the muscular lipid and glycogen contents. 0...
December 13, 2021: Scientific Reports
https://read.qxmd.com/read/34894393/disturbance-of-lipid-homeostasis-in-lysosomal-lipase-deficiency-%C3%A2-pathomechanism-diagnosis-and-treatment
#24
JOURNAL ARTICLE
Patryk Lipiński, Anna Tylki-Szymańska
Lysosomal acid lipase (LAL) plays a key role in lipid metabolism through the hydrolysis of cholesteryl esters and triglycerides in lysosomes. LAL deficiency is a rare autosomal recessive lysosomal storage disease caused by deleterious mutations in the LIPA gene. In the case of LAL deficiency, cholesteryl esters and triglycerides accumulate within the lysosomes. The up-regulation of endogenous cholesterol production, increased synthesis of apolipoprotein B (ApoB) and increased production of very-low-density lipoprotein cholesterol (VLDL-C) is observed...
September 30, 2021: Postepy Biochemii
https://read.qxmd.com/read/34876210/catalase-deficiency-facilitates-the-shuttling-of-free-fatty-acid-to-brown-adipose-tissue-through-lipolysis-mediated-by-ros-during-sustained-fasting
#25
JOURNAL ARTICLE
Raghbendra Kumar Dutta, Joon No Lee, Yunash Maharjan, Channy Park, Seong-Kyu Choe, Ye-Shih Ho, Raekil Park
BACKGROUND: Fatty acids (FA) derived from adipose tissue and liver serve as the main fuel in thermogenesis of brown adipose tissue (BAT). Catalase, a peroxisomal enzyme, plays an important role in maintaining intracellular redox homeostasis by decomposing hydrogen peroxide to either water or oxygen that oxidize and provide fuel for cellular metabolism. Although the antioxidant enzymatic activity of catalase is well known, its role in the metabolism and maintenance of energy homeostasis has not yet been revealed...
December 7, 2021: Cell & Bioscience
https://read.qxmd.com/read/34872433/effects-of-sparcl1-on-the-proliferation-and-differentiation-of-sheep-preadipocytes
#26
JOURNAL ARTICLE
Cheng Xiao, Hai Guo Jin, Li Chun Zhang, Jian Qiang Liu, Ming He, Hui Hai Ma, Yong Sheng Yu, Yang Cao
Important candidate genes that regulate lipid metabolism have the potential to increase the content of intramuscular fat (IMF) and improve meat quality. Secreted protein acidic and rich in cysteine like 1 ( SPARCL1 ) is a secreted glycoprotein with important physiological functions and is involved in the proliferation and differentiation of various cells. However, the role of the SPARCL1 gene in sheep preadipocytes and its regulatory mechanism is still unclear. In this study, we explored the effect of SPARCL1 on the proliferation and differentiation of sheep preadipocytes...
December 2021: Adipocyte
https://read.qxmd.com/read/34821370/mir%C3%A2-30a%C3%A2-5p-induces-the-adipogenic-differentiation-of-bone-marrow-mesenchymal-stem-cells-by-targeting-fam13a-wnt-%C3%AE-%C3%A2-catenin-signaling-in-aplastic-anemia
#27
JOURNAL ARTICLE
Enbo Wang, Yunyan Zhang, Rongmei Ding, Xiaohua Wang, Shumin Zhang, Xinghua Li
Aplastic anemia (AA) is a bone marrow failure syndrome with high morbidity and mortality. Bone marrow (BM)‑mesenchymal stem cells (MSCs) are the main components of the BM microenvironment, and dysregulation of BM‑MSC adipogenic differentiation is a pathologic hallmark of AA. MicroRNAs (miRNAs/miRs) are crucial regulators of multiple pathological processes such as AA. However, the role of miR‑30a‑5p in the modulation of BM‑MSC adipogenic differentiation in AA remains unclear. The present study aimed to explore the effect of miR‑30a‑5p on AA BM‑MSC adipogenic differentiation and the underlying mechanism...
January 2022: Molecular Medicine Reports
https://read.qxmd.com/read/34807469/lpl-aqp7-gpd2-promotes-glycerol-metabolism-under-hypoxia-and-prevents-cardiac-dysfunction-during-ischemia
#28
JOURNAL ARTICLE
Sohta Ishihama, Satoya Yoshida, Tatsuya Yoshida, Yu Mori, Noriyuki Ouchi, Shunsuke Eguchi, Teruhiro Sakaguchi, Takuma Tsuda, Katsuhiro Kato, Yuuki Shimizu, Koji Ohashi, Takahiro Okumura, Yasuko K Bando, Hiroaki Yagyu, Nina Wettschureck, Naoto Kubota, Stefan Offermanns, Takashi Kadowaki, Toyoaki Murohara, Mikito Takefuji
In the heart, fatty acid is a major energy substrate to fuel contraction under aerobic conditions. Ischemia downregulates fatty acid metabolism to adapt to the limited oxygen supply, making glucose the preferred substrate. However, the mechanism underlying the myocardial metabolic shift during ischemia remains unknown. Here, we show that lipoprotein lipase (LPL) expression in cardiomyocytes, a principal enzyme that converts triglycerides to free fatty acids and glycerol, increases during myocardial infarction (MI)...
December 2021: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/34774639/sebelipase-alfa-in-children-and-adults-with-lysosomal-acid-lipase-deficiency-final-results-of-the-arise-study
#29
JOURNAL ARTICLE
Barbara K Burton, François Feillet, Katryn N Furuya, Sachin Marulkar, Manisha Balwani
BACKGROUND & AIMS: Children and adults with lysosomal acid lipase deficiency (LAL-D) experience cirrhosis and dyslipidemia from lysosomal accumulation of cholesteryl esters and triglycerides. Sebelipase alfa enzyme replacement therapy is indicated for individuals with LAL-D. We report final results of the phase 3 randomized ARISE study of sebelipase alfa in children aged ≥4 years and adults with LAL-D. METHODS: The study included a 20-week, double-blind, placebo-controlled phase, a 130-week, open-label extension period, and a 104-week, open-label expanded treatment period...
November 10, 2021: Journal of Hepatology
https://read.qxmd.com/read/34685599/impaired-bile-acid-metabolism-and-gut-dysbiosis-in-mice-lacking-lysosomal-acid-lipase
#30
JOURNAL ARTICLE
Vinay Sachdev, Madalina Duta-Mare, Melanie Korbelius, Nemanja Vujić, Christina Leopold, Jan Freark de Boer, Silvia Rainer, Peter Fickert, Dagmar Kolb, Folkert Kuipers, Branislav Radovic, Gregor Gorkiewicz, Dagmar Kratky
Lysosomal acid lipase (LAL) is the sole enzyme known to be responsible for the hydrolysis of cholesteryl esters and triglycerides at an acidic pH in lysosomes, resulting in the release of unesterified cholesterol and free fatty acids. However, the role of LAL in diet-induced adaptations is largely unexplored. In this study, we demonstrate that feeding a Western-type diet to Lal-deficient (LAL-KO) mice triggers metabolic reprogramming that modulates gut-liver cholesterol homeostasis. Induction of ileal fibroblast growth factor 15 (three-fold), absence of hepatic cholesterol 7α-hydroxylase expression, and activation of the ERK phosphorylation cascade results in altered bile acid composition, substantial changes in the gut microbiome, reduced nutrient absorption by 40%, and two-fold increased fecal lipid excretion in LAL-KO mice...
October 1, 2021: Cells
https://read.qxmd.com/read/34667947/new-targets-for-nafld
#31
REVIEW
Lucia Parlati, Marion Régnier, Hervé Guillou, Catherine Postic
Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and progressive fibrosis. Several preclinical models (dietary and genetic animal models) of NAFLD have deepened our understanding of its aetiology and pathophysiology. Despite the progress made, there are currently no effective treatments for NAFLD. In this review, we will provide an update on the known molecular pathways involved in the pathophysiology of NAFLD and on ongoing studies of new therapeutic targets...
December 2021: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/34579081/crebh-systemically-regulates-lipid-metabolism-by-modulating-and-integrating-cellular-functions
#32
REVIEW
Yoshimi Nakagawa, Masaya Araki, Song-Iee Han, Yuhei Mizunoe, Hitoshi Shimano
Cyclic AMP-responsive element-binding protein H (CREBH, encoded by CREB3L3) is a membrane-bound transcriptional factor expressed in the liver and small intestine. The activity of CREBH is regulated not only at the transcriptional level but also at the posttranslational level. CREBH governs triglyceride metabolism in the liver by controlling gene expression, with effects including the oxidation of fatty acids, lipophagy, and the expression of apolipoproteins related to the lipoprotein lipase activation and suppression of lipogenesis...
September 15, 2021: Nutrients
https://read.qxmd.com/read/34543263/endothelial-lipase-mediates-efficient-lipolysis-of-triglyceride-rich-lipoproteins
#33
JOURNAL ARTICLE
Sumeet A Khetarpal, Cecilia Vitali, Michael G Levin, Derek Klarin, Joseph Park, Akhil Pampana, John S Millar, Takashi Kuwano, Dhavamani Sugasini, Papasani V Subbaiah, Jeffrey T Billheimer, Pradeep Natarajan, Daniel J Rader
Triglyceride-rich lipoproteins (TRLs) are circulating reservoirs of fatty acids used as vital energy sources for peripheral tissues. Lipoprotein lipase (LPL) is a predominant enzyme mediating triglyceride (TG) lipolysis and TRL clearance to provide fatty acids to tissues in animals. Physiological and human genetic evidence support a primary role for LPL in hydrolyzing TRL TGs. We hypothesized that endothelial lipase (EL), another extracellular lipase that primarily hydrolyzes lipoprotein phospholipids may also contribute to TRL metabolism...
September 2021: PLoS Genetics
https://read.qxmd.com/read/34496007/branched-chain-fatty-acid-synthesis-drives-tissue-specific-innate-immune-response-and-infection-dynamics-of-staphylococcus-aureus
#34
JOURNAL ARTICLE
Xi Chen, Wei Ping Teoh, Madison R Stock, Zachary J Resko, Francis Alonzo
Fatty acid-derived acyl chains of phospholipids and lipoproteins are central to bacterial membrane fluidity and lipoprotein function. Though it can incorporate exogenous unsaturated fatty acids (UFA), Staphylococcus aureus synthesizes branched chain fatty acids (BCFA), not UFA, to modulate or increase membrane fluidity. However, both endogenous BCFA and exogenous UFA can be attached to bacterial lipoproteins. Furthermore, S. aureus membrane lipid content varies based upon the amount of exogenous lipid in the environment...
September 2021: PLoS Pathogens
https://read.qxmd.com/read/34476902/effect-of-a-common-missense-variant-in-lipa-gene-on-fatty-liver-disease-and-lipid-phenotype-new-perspectives-from-a-single-center-observational-study
#35
JOURNAL ARTICLE
Andrea Pasta, Paolo Borro, Anna Laura Cremonini, Elena Formisano, Giulia Tozzi, Stefano Cecchi, Raffaele Fresa, Sara Labanca, Afscin Djahandideh, Samir Giuseppe Sukkar, Antonino Picciotto, Livia Pisciotta
Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive disease characterized by hypoalphalipoproteinemia, mixed hyperlipemia, and fatty liver (FL) due to mutations in LIPAse A, lysosomal acid type (LIPA) gene. The rs1051338 single-nucleotide polymorphism (SNP) in LIPA gene, in vitro, could adversely affect the LAL activity (LAL-A). Nonalcoholic fatty liver disease (NAFLD) is often associated with metabolic syndrome, and the diagnosis requires the exclusion of excess of alcohol intake and other causes of hepatic disease...
October 2021: Pharmacology Research & Perspectives
https://read.qxmd.com/read/34464873/dietary-copper-supplementation-enhances-lipolysis-in-rex-rabbits
#36
JOURNAL ARTICLE
Fan Li, Xiaojing Wu, Hongli Liu, Bin Zhang, Lei Liu, Fuchang Li
BACKGROUND: Copper is an important regulator of lipid metabolism in mammals, as a cofactor of many enzymes and is involved in the lipolysis. Copper deficiency has been considered as a significant factor in human diseases related to abnormal lipid metabolism, while adding copper to the diet seems to be the simplest and most effective way to prevent copper deficiency. AIMS: The aim of this study was to investigate the effects of dietary copper level on lipid metabolism in Rex Rabbits...
December 2021: Journal of Trace Elements in Medicine and Biology
https://read.qxmd.com/read/34373935/adaptation-of-ampk-mtor-signal-pathways-and-lipid-metabolism-in-response-to-low-and-high-level-rapeseed-meal-diet-in-chinese-perch-siniperca-chuatsi
#37
JOURNAL ARTICLE
Jiao Li, Xu-Fang Liang, Muhammad Shoaib Alam, Haocan Luo, Yanpeng Zhang, Binbin Peng, Qianqian Xiao, Zhilu Zhang, Liwei Liu, Shan He
It is well known that carnivorous fish cannot use plant-proteins efficiently. They affect lipid metabolism of fish and cause serious problems to fish health. The reasons for this deficiency of fish metabolism are not known well. Chinese perch, a carnivorous fish, can accept artificial diet after domestication and is also considered as a novel model of fish for nutrition studies. Therefore, the aim of this study was to explore the effect of fish meal replacement by low- or high-rapeseed meal on lipid and glucose metabolism of Chinese perch...
August 9, 2021: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://read.qxmd.com/read/34324844/two-novel-mutations-of-the-lpl-gene-in-two-chinese-family-cases-with-familial-chylomicronemia-syndrome
#38
JOURNAL ARTICLE
Mingying Wang, Yuantao Zhou, Xiaoli He, Chengjun Deng, Xiaoning Liu, Juan Li, Lin Zhou, Ying Li, Yu Zhang, Haifeng Liu, Li Li
The aim of this study was to investigate the clinical features and genetic causes of two family cases with familial chylomicronemia syndrome (FCS). Clinical manifestations of proband 1 and her families, and also proband 2 showed severe hypertriglyceridemia, especially the triglycerides levels of two probands were extremely high. Gene sequencing results showed that the LPL genes in each of the two probands had a new mutation site. For the proband 1, a compound heterozygous mutation at c.429 (c.429 + 1G > T) was detected in the LPL gene, which was splicing mutation and inherited from her mother...
July 27, 2021: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/34255741/hepatocyte-specific-suppression-of-angptl4-improves-obesity-associated-diabetes-and-mitigates-atherosclerosis-in-mice
#39
JOURNAL ARTICLE
Abhishek K Singh, Balkrishna Chaube, Xinbo Zhang, Jonathan Sun, Kathryn M Citrin, Alberto Canfrán-Duque, Binod Aryal, Noemi Rotllan, Luis Varela, Richard G Lee, Tamas L Horvath, Nathan Price, Yajaira Suárez, Carlos Fernandez-Hernando
Hepatic uptake and biosynthesis of fatty acids (FA), as well as the partitioning of FA into oxidative, storage, and secretory pathways are tightly regulated processes. Dysregulation of one or more of these processes can promote excess hepatic lipid accumulation, ultimately leading to systemic metabolic dysfunction. Angiopoietin-like-4 (ANGPTL4) is a secretory protein that inhibits lipoprotein lipase (LPL) and modulates triacylglycerol (TAG) homeostasis. To understand the role of ANGPTL4 in liver lipid metabolism under normal and high-fat fed conditions, we generated hepatocyte specific Angptl4 mutant mice (Hmut)...
July 13, 2021: Journal of Clinical Investigation
https://read.qxmd.com/read/34128469/eruptive-xanthoma-model-reveals-endothelial-cells-internalize-and-metabolize-chylomicrons-leading-to-extravascular-triglyceride-accumulation
#40
JOURNAL ARTICLE
Ainara G Cabodevilla, Songtao Tang, Sungwoon Lee, Adam E Mullick, Jose O Aleman, M Mahmood Hussain, William C Sessa, Nada A Abumrad, Ira J Goldberg
Although tissue uptake of fatty acids from chylomicrons is primarily via lipoprotein lipase (LpL) hydrolysis of triglycerides (TGs), studies of patients with genetic LpL deficiency suggest additional pathways deliver dietary lipids to tissues. Despite an intact endothelial cell (EC) barrier, hyperchylomicronemic patients accumulate chylomicron-derived lipids within skin macrophages, leading to the clinical finding eruptive xanthomas. We explored whether an LpL-independent pathway exists for transfer of circulating lipids across the EC barrier...
June 15, 2021: Journal of Clinical Investigation
keyword
keyword
107974
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.