James F Winchester, Jeffrey Silberzweig, Claudio Ronco, Viktoria Kuntsevich, Daniel Levine, Tom Parker, John A Kellum, Jamie A Salsberg, Peter Quartararo, Nathan W Levin
Renal replacement therapy in acute renal failure (ARF) and chronic renal failure (end-stage renal disease; ESRD) has been based on the use of modifications of dialysis (continuous arteriovenous hemofiltration and hemodiafiltration) to remove middle-molecular-weight toxins, consisting of low-molecular-weight proteins and peptides (LMWP) and cytokines involved in inflammation. High-flux dialyzers are not efficient at removing LMWP, and for this reason, sorbents have been studied to augment or replace dialysis...
2004: Blood Purification