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https://www.readbyqxmd.com/read/29330673/vacuum-assisted-closure-therapy-of-paradoxical-reaction-in-tuberculous-lymphadenopathy-caused-by-mycobacterium-africanum
#1
H F Geerdes-Fenge, P Pongratz, J Liese, E C Reisinger
A 26-year-old HIV-negative male from Ghana was treated for cervical, intrathoracic and abdominal lymph node tuberculosis (TB) and tuberculous hepatitis. Penetration of the thoracic trachea by a mediastinal lymph node had caused bronchomucosal TB. Sputum culture grew M. africanum, sensitive to all first-line antituberculous drugs. Four weeks after the beginning of directly observed treatment with isoniazid, rifampin, pyrazinamide and ethambutol, the right cervical lymph node increased in size, liquefied and caused a spontaneous fistula...
January 12, 2018: Infection
https://www.readbyqxmd.com/read/29330384/detection-of-apparent-cell-free-m-tuberculosis-dna-from-plasma
#2
E S Click, W Murithi, G S Ouma, K McCarthy, M Willby, S Musau, H Alexander, E Pevzner, J Posey, K P Cain
New diagnostics are needed to improve clinicians' ability to detect tuberculosis (TB) disease in key populations such as children and persons living with HIV and to rapidly detect drug resistance. Circulating cell-free DNA (ccfDNA) in plasma is a diagnostic target in new obstetric and oncologic applications, but its utility for diagnosing TB is not known. Here we show that Mycobacterium tuberculosis complex DNA can be detected in plasma of persons with sputum smear-positive TB, even in the absence of mycobacteremia...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329967/-prevalence-of-hiv-tuberculosis-co-infection-and-hiv-impact-on-patients-with-tuberculosis-in-the-lubumbashi-health-zone-from-2014%C3%A2-to-2015
#3
E N Wa Ilunga, R K Muya, A A Kaponda, C M A Kaput, S M Kalonji, V B Chiribagula, B N Nshikala, A N N'sasi, J-B L Simbi
BACKGROUND: Tuberculosis and HIV/AIDS are a dangerous couple in sub-Saharan Africa. The aim of this paper is to evaluate the prevalence of the co-infection tuberculosis/HIV/AIDS and its impact on issues of tuberculosis patients treated in Lubumbashi Heath Zone (LHZ). MATERIALS AND METHODS: A retrospective and transversal study was conducted through the analysis of tuberculosis patients' data admitted in the tuberculosis Health Centers for Diagnosis and treatment (HCDT) in the LHZ from January 2014 to December 2015...
January 9, 2018: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29327734/clinical-study-of-extrapulmonary-head-and-neck-tuberculosis-in-an-urban-setting
#4
S Monga, J N Malik, S Jan, S Bahadur, S Jetley, H Kaur
Tuberculosis (TB) of the head and neck region is quite common in endemic countries, but is still misdiagnosed due to its varied presentation and different sites of involvement. The aims of the present study were to present the diversities of presentation of head and neck tuberculosis with the diagnostic predicaments faced during evaluation and to assess treatment response to anti-tubercular treatment (ATT). We analysed 48 patients with head and neck tuberculosis who presented to the Department of Otorhinolaryngology in our tertiary care urban hospital over a period of two years from 2013 to 2015 and recorded their data, which included presenting complaints, local and systemic examination findings, investigation results and treatment outcomes...
December 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29327419/treatment-interruption-in-hiv-positive-patients-followed-up-in-cameroon-s-antiretroviral-treatment-program-individual-and-healthcare-supply-related-factors-anrs-12288-evolcam-survey
#5
Christelle Tong, Marie Suzan-Monti, Luis Sagaon-Teyssier, Mohamed Mimi, Christian Laurent, Gwenaëlle Maradan, Marie-Thérèse Mengue, Bruno Spire, Christopher Kuaban, Laurent Vidal, Sylvie Boyer
INTRODUCTION: Decreasing international financial resources for HIV and increasing numbers of antiretroviral treatment (ART) treated patients may jeopardize treatment continuity in low income settings. Using data from the EVOLCam ANRS-12288 survey, this study aimed to document the prevalence of unplanned treatment interruption for more than 2 consecutive days (TI>2d) and investigate associated individual and healthcare supply-related factors within the Cameroonian ART Program. METHODS: A cross-sectional mixed methods survey was carried out between April and December 2014 in 19 HIV services of the Center and Littoral regions...
January 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29325139/does-oxidative-stress-contribute-to-adverse-outcomes-in-hiv-associated-tb
#6
Wing-Wai Yew, Denise P Chan, Amit Singhal, Ying Zhang, Shui-Shan Lee
In HIV infection, oxidative stress is a pronounced phenomenon, with likely links to HIV-related pathologies and the progression of HIV infection per se. TB is an AIDS-defining condition. HIV-associated oxidative stress, like that associated with diabetes mellitus, might adversely impact the outcomes of TB, probably through increased propensity for generation of metabolically dormant mycobacterial persisters, alongside other mechanisms. This hypothesis might help in guiding the exploration of relevant research directions to improve the care of patients...
January 8, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29324985/urine-tb-lipoarabinomannan-lam-predicts-mortality-in-hospitalized-hiv-infected-children
#7
Sylvia M LaCourse, Lisa M Cranmer, Irene N Njuguna, John Gatimu, Joshua Stern, Elizabeth Maleche-Obimbo, Judd L Walson, Dalton Wamalwa, Grace John-Stewart, Patricia Pavlinac
Despite diagnostic performance limitations, urine lipoarabinomannan (LAM) predicts death in HIV-infected adults with TB. Pediatric data are limited. Among 137 hospitalized HIV-infected children, mortality was 4.9-fold higher among LAM-positives (127 vs. 31/100 py, aHR 4.92 [95%CI 1.79-13.49]; p=0.002). LAM identifies HIV-infected children at risk for death potentially missed by respiratory sampling.
January 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29323108/clinical-study-of-tuberculosis-in-the-head-and-neck-region-11-years-experience-and-a-review-of-the-literature
#8
Pai Pang, Weiyi Duan, Shuchun Liu, Shuang Bai, Yanan Ma, Ruiwu Li, Fayu Liu, Changfu Sun
Tuberculosis (TB) is an infectious disease and major health concern. Head and neck tuberculosis (HNTB) is relatively rare, but can arise in many regions, including the lymph nodes, larynx, oral cavity and pharynx. We retrospectively reviewed the clinical records of 60 patients diagnosed with HNTB in our department between March 2005 and January 2016. A review and summary of previous HNTB articles published in PubMed since 1885 was also performed. The subjects consisted of 17 males and 43 females, and the average age of patients was 45 ± 14...
January 10, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29313506/prevalence-of-tb-hiv-coinfection-in-antiretroviral-na%C3%A3-ve-patients-at-the-fann-ambulatory-treatment-center-in-dakar
#9
D Ka, N F Ngom Guéye, N Fall, N O Touré-Badiane, N Diop, G Batista, K Ndiaye, C T Ndour, M Seydi, M A Faye
To determine the prevalence of tuberculosis and describe its epidemiological, clinical, paraclinical, and therapeutic characteristics and its outcome in patients with HIV. This retrospective, descriptive, and analytical study examined the records of patients with HIV at our outpatient treatment center and selected those who were antiretroviral-naive and presented tuberculosis between January 2008 and December 2012. Among a total of 757 HIV-positive patients, 76 had tuberculosis, for a prevalence of 10 %. The sex ratio of 1...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29310659/the-impact-of-rural-residence-and-hiv-infection-on-poor-tuberculosis-treatment-outcomes-in-a-large-urban-hospital-a-retrospective-cohort-analysis
#10
Aishatu Lawal Adamu, Muktar H Aliyu, Najiba Aliyu Galadanci, Baba Maiyaki Musa, Umar Muhammad Lawan, Usman Bashir, Ibrahim Abubakar
BACKGROUND: Successful tuberculosis (TB) treatment is essential to effective TB control. TB-HIV coinfection, social determinants and access to services influenced by rural residence can affect treatment outcome. We examined the separate and joint effects of rural residence and HIV infection on poor treatment outcome among patients enrolled in a large TB treatment centre in Kano, Nigeria. METHODS: We retrospectively analysed a cohort of patients with TB enrolled in a large urban TB clinic in northern Nigeria, from January 2010 to December 2014...
January 8, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29304247/resistance-and-susceptibility-to-mycobacterium-tuberculosis-infection-and-disease-in-tuberculosis-households-in-kampala-uganda
#11
Catherine M Stein, Sarah Zalwango, LaShaunda L Malone, Bonnie Thiel, Ezekiel Mupere, Mary Nsereko, Brenda Okware, Hussein Kisingo, Christina L Lancioni, Charles M Bark, Christopher C Whalen, Moses L Joloba, W Henry Boom, Harriet Mayanja-Kizza
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major public health problem. Household contact studies identify children and adults along the spectrum from Mtb exposure to disease. In the Kawempe Community Health Study, conducted in Kampala, Uganda, 872 culture-confirmed pulmonary TB cases and their 2,585 contacts were enrolled between 2002-2012 and followed for up to 2 years each. Risk factors identified by time-to-event analysis for secondary TB differed among children, women and men...
January 3, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29302148/association-of-risk-factors-and-drug-resistance-pattern-in-tuberculosis-patients-in-north-india
#12
Pallavi Sinha, G N Srivastava, Anamika Gupta, Shampa Anupurba
Context: India is one of the high tuberculosis (TB) burden countries in the world. Improper implementation in the guidelines for the management of TB and high rate of defaults on the part of the patients are most important risk factors for the development of multi-drug resistant TB. Aims: This study examines the drug resistance profile and the effect of demographic, clinical and behavioral risk factors on the prevalence of TB and multidrug resistance (MDR) in north India...
October 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29300723/sexual-intercourse-among-high-school-students-29-states-and-united-states-overall-2005-2015
#13
Kathleen A Ethier, Laura Kann, Timothy McManus
Early initiation of sexual activity is associated with having more sexual partners, not using condoms, sexually transmitted infection (STI), and pregnancy during adolescence (1,2). The majority of adolescents initiate sexual activity during high school, and the proportion of high school students who have ever had sexual intercourse increases by grade; black students are more likely to have ever had sexual intercourse than are white students (3). The proportion of high school students overall who had ever had sexual intercourse did not change significantly during 1995-2005 (53...
January 5, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29300218/-give-me-some-time-facilitators-of-and-barriers-to-uptake-of-home-based-hiv-testing-during-household-contact-investigation-for-tuberculosis-in-kampala-uganda
#14
Mari Armstrong-Hough, Joseph Ggita, Irene Ayakaka, David Dowdy, Adithya Cattamanchi, Jessica E Haberer, Achilles Katamba, J Lucian Davis
BACKGROUND: Integrating home-based HIV counseling and testing (HCT) with tuberculosis (TB) evaluation could improve uptake of HIV testing among household contacts of patients with active TB. We sought to identify the facilitators of and barriers to HCT during household contact investigation for TB in Kampala, Uganda. METHODS: We nested semi-structured interviews with 28 household contacts who were offered home-based HCT in a household-randomized trial of home-based strategies for TB contact investigation...
January 3, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29297443/screening-for-active-tuberculosis-before-isoniazid-preventive-therapy-among-hiv-infected-west-african-adults
#15
R Moh, A Badjé, J-B N'takpé, G M Kouamé, D Gabillard, T Ouassa, E Ouattara, J Le Carrou, F Bohoussou, E Messou, S Eholié, X Anglaret, C Danel
SETTING: TEMPRANO was a multicentre, open-label trial in which human immunodeficiency virus (HIV) infected adults with high CD4 counts were randomised into early or deferred antiretroviral therapy (ART) arms with or without 6-month isoniazid preventive therapy (IPT) in a setting where the World Health Organization (WHO) recommends IPT in HIV-infected patients. Despite the WHO recommendation, IPT coverage remains low due to fear of the presence of undiagnosed active TB before prescribing IPT, and the related risk of drug resistance...
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297441/tackling-tuberculosis-in-sub-saharan-africa-edctp-achievements-and-the-road-ahead
#16
M A Surette, P Beattie, T Nyirenda, O F Olesen
The European and Developing Countries Clinical Trials Partnership (EDCTP) was established in 2003 to accelerate the development of medical interventions for tuberculosis (TB), human immunodeficiency virus (HIV) and malaria, with a particular focus on Phase II and III clinical trials. Between 2003 and 2015, the first EDCTP programme committed €65.6 million to research on TB and TB-HIV co-infection. The programme made a significant contribution to the first three elements of the DOTS TB control strategy, which mobilised European and African funding for TB-related research and generated important evidence on TB diagnostics and treatment regimens...
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297437/test-and-treat-for-tb-hiv
#17
Renee Ridzon
No abstract text is available yet for this article.
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297428/bacterial-co-infection-and-early-mortality-among-pulmonary-tuberculosis-patients-in-manila-the-philippines
#18
T Shimazaki, T Taniguchi, N R D Saludar, L M Gustilo, T Kato, A Furumoto, K Kato, N Saito, W S Go, E S Tria, E P Salva, E M Dimaano, C Parry, K Ariyoshi, J B Villarama, M Suzuki
OBJECTIVE: To investigate the prevalence of bacterial co-infection and its effect on early mortality among hospitalised human immunodeficiency virus (HIV) negative pulmonary tuberculosis (PTB) patients in Manila, the Philippines. DESIGN: A prospective observational study was conducted at a national infectious disease hospital. HIV-negative PTB patients aged 13 years hospitalised from November to December 2011 and from December 2012 to May 2013 were enrolled. Sputum samples were tested for Mycobacterium tuberculosis and six respiratory bacterial pathogens using polymerase chain reaction (PCR)...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297424/household-context-and-psychosocial-impact-of-childhood-multidrug-resistant-tuberculosis-in-kwazulu-natal-south-africa
#19
M Loveday, B Sunkari, I Master, A Daftary, V Mehlomakulu, S Hlangu, B J Marais
SETTING: Referral hospital for drug-resistant tuberculosis (TB) in KwaZulu-Natal, South Africa. OBJECTIVES: We conducted interviews with primary care givers of children admitted with multidrug-resistant TB (MDR-TB) during a 3-month period in 2015 to identify broader household challenges. RESULTS: We interviewed 26 care givers, most of whom were women (85%). Most households had been decimated by TB/MDR-TB and human immunodeficiency virus (HIV) infection, and were dependent upon government grants...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29291251/gaps-in-the-child-tuberculosis-care-cascade-in-32-rural-communities-in-uganda-and-kenya
#20
Florence Mwangwa, Gabriel Chamie, Dalsone Kwarisiima, James Ayieko, Asiphas Owaraganise, Theodore D Ruel, Albert Plenty, Khai Hoan Tram, Tamara D Clark, Craig R Cohen, Elizabeth A Bukusi, Maya Petersen, Moses R Kamya, Edwin D Charlebois, Diane V Havlir, Carina Marquez
Background: Reducing tuberculosis (TB) deaths among children requires a better understanding of the gaps in the care cascade from TB diagnosis to treatment completion. We sought to assess the child TB care cascade in 32 rural communities in Uganda and Kenya using programmatic data. Methods: This is a retrospective cohort study of 160,851 children (ages <15 years) living in 12 rural communities in Kenya and 22 in Uganda. We reviewed national TB registries from health centers in and adjacent to the 32 communities, and we included all child TB cases recorded from January 1, 2013 to June 30, 2016...
December 2017: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
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