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https://www.readbyqxmd.com/read/28926565/a-snp-panel-and-online-tool-for-checking-genotype-concordance-through-comparing-qr-codes
#1
Yonghong Du, Joshua S Martin, John McGee, Yuchen Yang, Eric Yi Liu, Yingrui Sun, Matthias Geihs, Xuejun Kong, Eric Lingfeng Zhou, Yun Li, Jie Huang
In the current precision medicine era, more and more samples get genotyped and sequenced. Both researchers and commercial companies expend significant time and resources to reduce the error rate. However, it has been reported that there is a sample mix-up rate of between 0.1% and 1%, not to mention the possibly higher mix-up rate during the down-stream genetic reporting processes. Even on the low end of this estimate, this translates to a significant number of mislabeled samples, especially over the projected one billion people that will be sequenced within the next decade...
2017: PloS One
https://www.readbyqxmd.com/read/28925997/precision-annotation-of-digital-samples-in-ncbi-s-gene-expression-omnibus
#2
Dexter Hadley, James Pan, Osama El-Sayed, Jihad Aljabban, Imad Aljabban, Tej D Azad, Mohamad O Hadied, Shuaib Raza, Benjamin Abhishek Rayikanti, Bin Chen, Hyojung Paik, Dvir Aran, Jordan Spatz, Daniel Himmelstein, Maryam Panahiazar, Sanchita Bhattacharya, Marina Sirota, Mark A Musen, Atul J Butte
The Gene Expression Omnibus (GEO) contains more than two million digital samples from functional genomics experiments amassed over almost two decades. However, individual sample meta-data remains poorly described by unstructured free text attributes preventing its largescale reanalysis. We introduce the Search Tag Analyze Resource for GEO as a web application (http://STARGEO.org) to curate better annotations of sample phenotypes uniformly across different studies, and to use these sample annotations to define robust genomic signatures of disease pathology by meta-analysis...
September 19, 2017: Scientific Data
https://www.readbyqxmd.com/read/28925292/using-a-media-campaign-to-increase-engagement-with-a-mobile-based-youth-smoking-cessation-program
#3
Amy Sanders, Cendrine Robinson, Shani C Taylor, Samantha D Post, Jeffrey Goldfarb, Rui Shi, Yvonne M Hunt, Erik M Augustson
PURPOSE: To describe the impact of the National Cancer Institute's promotion of its youth smoking cessation program, Smokefree Teen (SFT). DESIGN: We provide a description of campaign strategies and outcomes as a means to engage a teen audience in cessation resources using a cost-effective approach. SETTING: The campaign occurred nationally, using traditional (TV and radio), online, and social media outreach. PARTICIPANTS: Ads targeted adolescent smokers (aged 14-17)...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28922337/role-of-the-internet-as-an-information-resource-before-anaesthesia-consultation-a-french-prospective-multicentre-survey
#4
Bastian Nucci, Pierre-Geraud Claret, Gilles Leclerc, Arnaud Chaumeron, Philippe Grillo, Clément Buleon, Vincent Leprince, Mathieu Raux, Vincent Minville, Emmanuel Futier, Jean-Yves Lefrant, Philippe Cuvillon
BACKGROUND: Use of the internet as an information search tool has increased dramatically. Our study assessed preoperative use of the internet by patients to search for information regarding anaesthesia, surgery, pain or outcomes. OBJECTIVE(S): The aim of this study was to test whether patients used the internet prior to surgery and what kinds of information they looked for (anaesthetic technique, pain, adverse events, outcomes and surgery). Correlation between patient age and information sought about surgery from the internet was also explored...
September 16, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28915877/vole-abundance-and-reindeer-carcasses-determine-breeding-activity-of-arctic-foxes-in-low-arctic-yamal-russia
#5
Dorothee Ehrich, Maite Cerezo, Anna Y Rodnikova, Natalya A Sokolova, Eva Fuglei, Victor G Shtro, Aleksandr A Sokolov
BACKGROUND: High latitude ecosystems are at present changing rapidly under the influence of climate warming, and specialized Arctic species at the southern margin of the Arctic may be particularly affected. The Arctic fox (Vulpes lagopus), a small mammalian predator endemic to northern tundra areas, is able to exploit different resources in the context of varying tundra ecosystems. Although generally widespread, it is critically endangered in subarctic Fennoscandia, where a fading out of the characteristic lemming cycles and competition with abundant red foxes have been identified as main threats...
September 16, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28915808/fall-prevention-is-the-stratify-tool-the-right-instrument-in-italian-hospital-inpatient-a-retrospective-observational-study
#6
Greta Castellini, Antonia Demarchi, Monica Lanzoni, Silvana Castaldi
BACKGROUND: Although several risk assessment tools are in use, uncertainties on their accuracy in detecting fall risk already exist. Choosing the most accurate tool for hospital inpatient is still a challenge for the organizations. We aimed to retrospectively assess the appropriateness of a fall risk prevention program with the STRATIFY assessment tool in detecting acute-care inpatient fall risk. METHODS: Number of falls and near falls, occurred from January 2014 to March 2015, was collected through the incident reporting web-system implemented in the hospital's intranet...
September 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28915456/carbon-and-nitrogen-elemental-and-isotopic-ratios-of-filter-feeding-bivalves-along-the-french-coasts-an-assessment-of-specific-geographic-seasonal-and-multi-decadal-variations
#7
Nicolas Briant, Nicolas Savoye, Tiphaine Chouvelon, Valérie David, Samuel Rodriguez, Karine Charlier, Jeroen E Sonke, Jean François Chiffoleau, Christophe Brach-Papa, Joël Knoery
Primary consumers play a key role in coastal ecosystems by transferring organic matter from primary producers to predators. Among them, suspension-feeders, like bivalve molluscs are widely used in trophic web studies. The main goal of this study was to investigate variations of C and N elemental and isotopic ratios in common bivalves (M. edulis, M. galloprovincialis, and C. gigas) at large spatial (i.e. among three coastal regions) and different temporal (i.e. from seasonal to multi-decadal) scales in France, in order to identify potential general or specific patterns and speculate on their drivers...
September 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28913717/after-deployment-adaptive-parenting-tools-1-year-outcomes-of-an-evidence-based-parenting-program-for-military-families-following-deployment
#8
Abigail H Gewirtz, David S DeGarmo, Osnat Zamir
Despite significant stressors facing military families over the past 15 years of wars in Iraq and Afghanistan, no parenting programs adapted or developed for military families with school-aged children have been rigorously tested. We present outcome data from the first randomized controlled trial of a behavioral parent training program for families with a parent deployed to Iraq or Afghanistan. In the present study, 336 primarily National Guard and Reserve families with 4-12-year-old children were recruited from a Midwestern state...
September 15, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28910995/genomic-medicine-and-data-sharing
#9
Sobia Raza, Alison Hall
Introduction: Effective data sharing does not occur in the UK despite being essential for the delivery of high-quality genomic services to patients across clinical specialities and to optimize advances in genomic medicine. Sources of data: Original papers, reviews, guidelines, policy papers and web-resources. Areas of agreement: Data sharing for genomic medicine requires appropriate infrastructure and policies, together with acceptance by health professionals and the public of the necessity of data sharing for clinical care...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28904773/a-spatial-theory-for-emergent-multiple-predator-prey-interactions-in-food-webs
#10
Tobin D Northfield, Brandon T Barton, Oswald J Schmitz
Predator-prey interaction is inherently spatial because animals move through landscapes to search for and consume food resources and to avoid being consumed by other species. The spatial nature of species interactions necessitates integrating spatial processes into food web theory and evaluating how predators combine to impact their prey. Here, we present a spatial modeling approach that examines emergent multiple predator effects on prey within landscapes. The modeling is inspired by the habitat domain concept derived from empirical synthesis of spatial movement and interactions studies...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28904183/the-tb-portals-an-open-access-web-based-platform-for-global-drug-resistant-tuberculosis-data-sharing-and-analysis
#11
Alex Rosenthal, Andrei Gabrielian, Eric Engle, Darrell E Hurt, Sofia Alexandru, Valeriu Crudu, Eugene Sergueev, Valery Kirichenko, Vladzimir Lapitskii, Eduard Snezhko, Vassili Kovalev, Andrei Astrovko, Alena Skrahina, Jessica Taaffe, Michael Harris, Alyssa Long, Kurt Wollenberg, Irada Akhundova, Sharafat Ismayilova, Aliaksandr Skrahin, Elcan Mammadbayov, Hagigat Gadirova, Rafik Abuzarov, Mehriban Seyfaddinova, Zaza Avaliani, Irina Strambu, Dragos Zaharia, Alexandru Muntean, Eugenia Ghita, Miron Bogdan, Roxana Mindru, Victor Spinu, Alexandra Sora, Catalina Ene, Sergo Vashakidze, Natalia Shubladze, Ucha Nanava, Alexander Tuzikov, Michael Tartakovsky
The TB Portals Program is an international consortium of physicians, radiologists, and microbiologists from countries with a heavy burden of drug-resistant tuberculosis working with data scientists and IT professionals. Together, we have built the TB Portals, a repository of socioeconomic/geographic, clinical, laboratory, radiological, and genomic data from patient cases of drug-resistant tuberculosis and backed by shareable, physical samples. Currently, there are 1,299 total cases from five country sites (Azerbaijan, Belarus, Moldova, Georgia, and Romania), of which 976 (75...
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28904142/trophic-dynamics-of-a-simple-model-ecosystem
#12
Graham Bell, Étienne Fortier-Dubois
We have constructed a model of community dynamics that is simple enough to enumerate all possible food webs, yet complex enough to represent a wide range of ecological processes. We use the transition matrix to predict the outcome of succession and then investigate how the transition probabilities are governed by resource supply and immigration. Low-input regimes lead to simple communities whereas trophically complex communities develop when there is an adequate supply of both resources and immigrants. Our interpretation of trophic dynamics in complex communities hinges on a new principle of mutual replenishment, defined as the reciprocal alternation of state in a pair of communities linked by the invasion and extinction of a shared species...
September 13, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28902704/hiv-pre-exposure-prophylaxis-implementation-at-local-health-departments-a-statewide-assessment-of-activities-and-barriers
#13
Helen L Zhang, Sarah K Rhea, Christopher B Hurt, Victoria L Mobley, Heidi Swygard, Arlene C Seña, Mehri S McKellar
BACKGROUND: Expanding access to HIV pre-exposure prophylaxis (PrEP) could help reduce rates of HIV infection in the United States. This study characterizes activities and barriers to PrEP implementation at local health departments (LHDs) in North Carolina (NC), which contains a large rural population. METHODS: In May 2016, a web-based survey was distributed to health directors of all county and district health departments in NC to assess PrEP-related activities, perceived barriers to PrEP implementation, and desired PrEP-related resources...
September 11, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28902398/using-proteomescout-a-resource-of-post-translational-modifications-their-experiments-and-the-proteins-that-they-annotate
#14
Arshag D Mooradian, Jason M Held, Kristen M Naegle
Post-translational modifications (PTMs) of protein amino acids are ubiquitous and important to protein function, localization, degradation, and more. In recent years, there has been an explosion in the discovery of PTMs as a result of improvements in PTM measurement techniques, including quantitative measurements of PTMs across multiple conditions. ProteomeScout is a repository for such discovery and quantitative experiments and provides tools for visualizing PTMs within proteins, including where they are relative to other PTMS, domains, mutations, and structure...
September 13, 2017: Current Protocols in Bioinformatics
https://www.readbyqxmd.com/read/28902146/community-capacity-building-for-physical-activity-promotion-among-older-adults-a-literature-review
#15
REVIEW
Tobias Ubert, Sarah Forberger, Dirk Gansefort, Hajo Zeeb, Tilman Brand
Community-based interventions to promote physical activity (PA) among older adults are of high interest in health promotion since they promise to be effective strategies to reach this population group. Community capacity building, that is, the local promotion of knowledge, skills, commitment, structures, and leadership, is among the recommended core strategies. However, little guidance is provided on how to achieve a high degree of community capacity. This study aims to identify practical strategies to enhance community capacities for PA promotion among older adults (50 years or older) and to evaluate their success...
September 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28894744/advances-in-mobile-mental-health-opportunities-and-implications-for-the-spectrum-of-e-mental-health-services
#16
REVIEW
Donald M Hilty, Steven Chan, Tiffany Hwang, Alice Wong, Amy M Bauer
Mobile health (mHealth), telemedicine and other technology-based services facilitate mental health service delivery and may be considered part of an e-mental health (eMH) spectrum of care. Web- and Internet-based resources provide a great opportunity for the public, patients, healthcare providers and others to improve wellness, practice prevention and reduce suffering from illnesses. Mobile apps offer portability for access anytime/anywhere, are inexpensive versus traditional desktop computers, and have additional features (e...
2017: MHealth
https://www.readbyqxmd.com/read/28894695/which-obstacles-prevent-us-from-recruiting-into-clinical-trials-a-survey-about-the-environment-for-clinical-studies-at-a-german-university-hospital-in-a-comprehensive-cancer-center
#17
Christoph Straube, Peter Herschbach, Stephanie E Combs
BACKGROUND: Prospective clinical studies are the most important tool in modern medicine. The standard in good clinical practice in clinical trials has constantly improved leading to more sophisticated protocols. Moreover, translational questions are increasingly addressed in clinical trials. Such trials must follow elaborate rules and regulations. This is accompanied by a significant increase in documentation issues which require substantial manpower. Furthermore, university-based clinical centers are interested in increasing the amount of patients treated within clinical trials, and this number has evolved to be a key quality criterion...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28893755/a-randomised-controlled-trial-of-an-online-menu-planning-intervention-to-improve-childcare-service-adherence-to-dietary-guidelines-a-study-protocol
#18
Sze Lin Yoong, Alice Grady, John Wiggers, Victoria Flood, Chris Rissel, Meghan Finch, Andrew Searles, David Salajan, Ruby O'Rourke, Jaqueline Daly, Karen Gilham, Fiona Stacey, Alison Fielding, Nicole Pond, Rebecca Wyse, Kirsty Seward, Luke Wolfenden
INTRODUCTION: The implementation of dietary guidelines in childcare settings is recommended to improve child public health nutrition. However, foods provided in childcare services are not consistent with guidelines. The primary aim of the trial is to assess the effectiveness of a web-based menu planning intervention in increasing the mean number of food groups on childcare service menus that comply with dietary guidelines regarding food provision to children in care. METHODS AND ANALYSIS: A parallel group randomised controlled trial will be undertaken with 54 childcare services that provide food to children within New South Wales, Australia...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28890946/oncokb-a-precision-oncology-knowledge-base
#19
Debyani Chakravarty, Jianjiong Gao, Sarah M Phillips, Ritika Kundra, Hongxin Zhang, Jiaojiao Wang, Julia E Rudolph, Rona Yaeger, Tara Soumerai, Moriah H Nissan, Matthew T Chang, Sarat Chandarlapaty, Tiffany A Traina, Paul K Paik, Alan L Ho, Feras M Hantash, Andrew Grupe, Shrujal S Baxi, Margaret K Callahan, Alexandra Snyder, Ping Chi, Daniel Danila, Mrinal Gounder, James J Harding, Matthew D Hellmann, Gopa Iyer, Yelena Janjigian, Thomas Kaley, Douglas A Levine, Maeve Lowery, Antonio Omuro, Michael A Postow, Dana Rathkopf, Alexander N Shoushtari, Neerav Shukla, Martin Voss, Ederlinda Paraiso, Ahmet Zehir, Michael F Berger, Barry S Taylor, Leonard B Saltz, Gregory J Riely, Marc Ladanyi, David M Hyman, José Baselga, Paul Sabbatini, David B Solit, Nikolaus Schultz
PURPOSE: With prospective clinical sequencing of tumors emerging as a mainstay in cancer care, there is an urgent need for a clinical support tool that distills the clinical implications associated with specific mutation events into a standardized and easily interpretable format. To this end, we developed OncoKB, an expert-guided precision oncology knowledge base. METHODS: OncoKB annotates the biological and oncogenic effect and the prognostic and predictive significance of somatic molecular alterations...
July 2017: JCO Precis Oncol
https://www.readbyqxmd.com/read/28887530/persistence-of-a-stage-structured-food-web
#20
Akihiko Mougi
Contrary to a theoretical prediction, natural communities comprise many interacting species, thereby developing complex ecosystems. Earlier theoretical studies assumed that each component species within an ecological network has a simple life history, despite the fact that the interaction partners of many species, such as their predators and resources, change during the developmental stages. This poses an open question on the effect of life history complexity on the dynamics of communities. Here using a food web model, I showed that species with a stage-structured life cycle greatly changes the relationship between community complexity and persistence...
September 8, 2017: Scientific Reports
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