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https://www.readbyqxmd.com/read/29772722/ethnobotany-phytochemistry-and-pharmacological-effects-of-plants-in-genus-cynanchum-linn-asclepiadaceae
#1
REVIEW
Lu Han, Xiuping Zhou, Mengmeng Yang, Li Zhou, Xinxin Deng, Shijie Wei, Wenping Wang, Zhizhong Wang, Xue Qiao, Changcai Bai
Genus Cynanchum L. belongs to the family Asclepiadaceae, which comprise more than 200 species distributed worldwide. In Chinese medical practice, numerous drugs (such as tablets and powders) containing different parts of plants of this genus are used to treat snake bites, bruises, osteoblasts, rheumatoid arthritis and tumors. A search for original articles published on the cynanchum genus was performed by using several resources, including Flora of China Official Website and various scientific databases, such as PubMed, SciFinder, the Web of Science, Science Direct, and China Knowledge Resource Integrated (CNKI)...
May 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29771388/gwas4d-multidimensional-analysis-of-context-specific-regulatory-variant-for-human-complex-diseases-and-traits
#2
Dandan Huang, Xianfu Yi, Shijie Zhang, Zhanye Zheng, Panwen Wang, Chenghao Xuan, Pak Chung Sham, Junwen Wang, Mulin Jun Li
Genome-wide association studies have generated over thousands of susceptibility loci for many human complex traits, and yet for most of these associations the true causal variants remain unknown. Tissue/cell type-specific prediction and prioritization of non-coding regulatory variants will facilitate the identification of causal variants and underlying pathogenic mechanisms for particular complex diseases and traits. By leveraging recent large-scale functional genomics/epigenomics data, we develop an intuitive web server, GWAS4D (http://mulinlab...
May 16, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29770157/efficacy-of-suxiao-jiuxin-pill-on-coronary-heart-disease-a-meta-analysis-of-randomized-controlled-trials
#3
REVIEW
Li Ren, Jie Wang, Ling Feng, Shuli Wang, Jun Li
Suxiao jiuxin pill is considered an effective ancillary drug in patients with coronary heart disease. Although numerous small, single-center clinical trials have been conducted, the benefits and harms of suxiao jiuxin pill remain controversial. We performed a meta-analysis to clarify the efficacy of suxiao jiuxin pill on patients with coronary heart disease. Randomized controlled trials were identified by using the Cochrane Library, PubMed, Web of Science, Embase, Wanfang, Weipu, and China Knowledge Resource Integrated databases (until June 2016)...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29770143/a-census-of-tandemly-repeated-polymorphic-loci-in-genic-regions-through-the-comparative-integration-of-human-genome-assemblies
#4
Loredana M Genovese, Filippo Geraci, Lucia Corrado, Eleonora Mangano, Romina D'Aurizio, Roberta Bordoni, Marco Severgnini, Giovanni Manzini, Gianluca De Bellis, Sandra D'Alfonso, Marco Pellegrini
Polymorphic Tandem Repeat (PTR) is a common form of polymorphism in the human genome. A PTR consists in a variation found in an individual (or in a population) of the number of repeating units of a Tandem Repeat (TR) locus of the genome with respect to the reference genome. Several phenotypic traits and diseases have been discovered to be strongly associated with or caused by specific PTR loci. PTR are further distinguished in two main classes: Short Tandem Repeats (STR) when the repeating unit has size up to 6 base pairs, and Variable Number Tandem Repeats (VNTR) for repeating units of size above 6 base pairs...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29764887/how-effective-and-cost-effective-are-behaviour-change-interventions-in-improving-the-prescription-and-use-of-antibiotics-in-low-income-and-middle-income-countries-a-protocol-for-a-systematic-review
#5
Neha Batura, Carla Cuevas, Mishal Khan, Virginia Wiseman
INTRODUCTION: Antibiotic resistance endangers effective prevention and treatment of infections, and places significant burden on patients, families, communities and healthcare systems. Low-income and middle-income countries (LMICs) are especially vulnerable to antibiotic resistance, owing to high infectious disease burden, and limited resources for treatment. High prevalence of antibiotic prescription and use due to lack of provider's knowledge, prescriber's habits and perceived patient needs further exacerbate the situation...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29764633/national-preceptor-development-program-pdp-prototype-the-third-of-a-3-part-series
#6
Craig D Cox, Katrina Mulherin, Sheila Walter
INTRODUCTION: Preceptor development is critical to successful delivery of experiential learning. Although many preceptor development programs exist, a more individualized approach to training is needed. To accomplish this a national preceptor development program should be considered based on the continuing professional development model. A detailed prototype for this program has been described. METHODS: In this final installment of the series, the twelve evidence-based recommendations from the first installment were utilized to construct a prototype for a preceptor development program...
March 2018: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29764369/vareporter-variant-reporter-for-cancer-research-of-massive-parallel-sequencing
#7
Po-Jung Huang, Chi-Ching Lee, Ling-Ya Chiu, Kuo-Yang Huang, Yuan-Ming Yeh, Chia-Yu Yang, Cheng-Hsun Chiu, Petrus Tang
BACKGROUND: High throughput sequencing technologies have been an increasingly critical aspect of precision medicine owing to a better identification of disease targets, which contributes to improved health care cost and clinical outcomes. In particular, disease-oriented targeted enrichment sequencing is becoming a widely-accepted application for diagnostic purposes, which can interrogate known diagnostic variants as well as identify novel biomarkers from panels of entire human coding exome or disease-associated genes...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29762913/an-online-compendium-of-cho-rna-seq-data-allows-identification-of-cho-cell-line-specific-transcriptomic-signatures
#8
Ankita Singh, Helene F Kildegaard, Mikael R Andersen
Chinese hamster ovary (CHO) cell lines can fold, assemble and modify proteins post-translationally to produce human-like proteins; as a consequence, it is the single most common expression systems for industrial production of recombinant therapeutic proteins. A thorough knowledge of cultivation conditions of different CHO cell lines has been developed over the last decade, but comprehending gene or pathway-specific distinctions between CHO cell lines at transcriptome level remains a challenge. To address these challenges, we compiled a compendium of 23 RNA-Seq studies from public and in-house data on CHO cell lines, i...
May 15, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29762640/mrmassaydb-an-integrated-resource-for-validated-targeted-proteomics-assays
#9
Pallab Bhowmick, Yassene Mohammed, Christoph H Borchers
Motivation: Multiple Reaction Monitoring (MRM)-based targeted proteomics is increasingly being used to study the molecular basis of disease. When combined with an internal standard, MRM allows absolute quantification of proteins in virtually any type of sample but the development and validation of an MRM assay for a specific protein is laborious. Therefore, several public repositories now host targeted proteomics MRM assays, including NCI's Clinical Proteomic Tumor Analysis Consortium assay portals, PeptideAtlas SRM Experiment Library, SRMAtlas, PanoramaWeb, and PeptideTracker, with all of which contain different levels of information...
May 14, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29761465/a-multi-omics-database-for-parasitic-nematodes-and-trematodes
#10
John Martin, Rahul Tyagi, Bruce A Rosa, Makedonka Mitreva
Helminth.net ( www.helminth.net ) is a web-based resource that was launched in 2000 as simply " Nematode.net " to host and investigate gene sequences from nematode genomes. Over the years it has evolved to become the moniker for a collection of databases: Nematode.net and Trematode.net . These databases host information for 73 nematode (roundworms) and 17 trematode (flatworms) species and serve as backbone for a number of tools that allow users to query slices of the data for multifactorial combinations of species-omics properties...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29761464/echinobase-tools-for-echinoderm-genome-analyses
#11
Gregory A Cary, R Andrew Cameron, Veronica F Hinman
The echinoderms are a phylum of invertebrate deuterostome animals that constitute important research models for a number of biological disciplines. EchinoBase ( www.echinobase.org ) is an echinoderm-specific genome database and web information system that provides a platform for the interrogation and exploration of echinoderm genomic data. This chapter outlines the datasets available on EchinoBase; from assembled genomes and genome annotations, to spatial and quantitative expression data, as well as functional genomics datasets...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29761463/using-zfin-data-types-organization-and-retrieval
#12
Ceri E Van Slyke, Yvonne M Bradford, Douglas G Howe, David S Fashena, Sridhar Ramachandran, Leyla Ruzicka
The Zebrafish Model Organism Database (ZFIN; zfin.org) was established in 1994 as the primary genetic and genomic resource for the zebrafish research community. Some of the earliest records in ZFIN were for people and laboratories. Since that time, services and data types provided by ZFIN have grown considerably. Today, ZFIN provides the official nomenclature for zebrafish genes, mutants, and transgenics and curates many data types including gene expression, phenotypes, Gene Ontology, models of human disease, orthology, knockdown reagents, transgenic constructs, and antibodies...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29761462/navigating-xenbase-an-integrated-xenopus-genomics-and-gene-expression-database
#13
Christina James-Zorn, Virgilio Ponferrada, Malcolm E Fisher, Kevin Burns, Joshua Fortriede, Erik Segerdell, Kamran Karimi, Vaneet Lotay, Dong Zhuo Wang, Stanley Chu, Troy Pells, Ying Wang, Peter D Vize, Aaron Zorn
Xenbase is the Xenopus model organism database ( www.xenbase.org ), a web-accessible resource that integrates the diverse genomic and biological data for Xenopus research. It hosts a variety of content including current and archived genomes for both X. laevis and X. tropicalis, bioinformatic tools for comparative genetic analyses including BLAST and GBrowse, annotated Xenopus literature, and catalogs of reagents including antibodies, ORFeome clones, morpholinos, and transgenic lines. Xenbase compiles gene-specific pages which include manually curated gene expression images, functional information including gene ontology (GO), disease associations, and links to other major data sources such as NCBI:Entrez, UniProtKB, and Ensembl...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29761461/bovine-genome-database-tools-for-mining-the-bos-taurus-genome
#14
Darren E Hagen, Deepak R Unni, Aditi Tayal, Gregory W Burns, Christine G Elsik
The Bovine Genome Database (BGD; http://bovinegenome.org ) is a web-accessible resource that supports bovine genomics research by providing genome annotation and data mining tools. BovineMine is a tool within BGD that integrates BGD data, including the genome, genes, precomputed gene expression levels and variant consequences, with external data sources that include quantitative trait loci (QTL), orthologues, Gene Ontology, gene interactions, and pathways. BovineMine enables researchers without programming skills to create custom integrated datasets for use in downstream analyses...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29761459/mouse-genome-informatics-mgi-is-the-international-resource-for-information-on-the-laboratory-mouse
#15
MeiYee Law, David R Shaw
Mouse Genome Informatics (MGI, http://www.informatics.jax.org/ ) web resources provide free access to meticulously curated information about the laboratory mouse. MGI's primary goal is to help researchers investigate the genetic foundations of human diseases by translating information from mouse phenotypes and disease models studies to human systems. MGI provides comprehensive phenotypes for over 50,000 mutant alleles in mice and provides experimental model descriptions for over 1500 human diseases. Curated data from scientific publications are integrated with those from high-throughput phenotyping and gene expression centers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29760862/free-open-access-medical-education-foam-in-emergency-medicine-the-global-distribution-of-users-in-2016
#16
Taylor W Burkholder, Jennifer W Bellows, Renee A King
Introduction: Free open-access medical education (FOAM) is a collection of interactive online medical education resources-free and accessible to students, physicians and other learners. This novel approach to medical education has the potential to reach learners across the globe; however, the extent of its global uptake is unknown. Methods: This descriptive report evaluates the 2016 web analytics data from a convenience sample of FOAM blogs and websites with a focus on emergency medicine (EM) and critical care...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29757846/increasing-diabetic-patient-engagement-and-self-reported-medication-adherence-using-a-web-based-multimedia-program
#17
Kerri Elsabrout
BACKGROUND AND PURPOSE: Evidence-based, multimedia applications to supplement clinical care can improve patient engagement and clinical outcomes. Patients with diabetes with potentially devastating complication of foot ulcers present a substantial opportunity to improve engagement. This project examines how providing an online, multimedia self-management program affects patient engagement and self-reported medication adherence scores within 4-6 weeks compared with preprogram scores. METHODS: Participants included 14 adult, diabetic outpatients receiving care at a Wound Care Center in suburban New York...
May 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29752471/author-correction-transcriptomic-signature-of-drought-response-in-pearl-millet-pennisetum-glaucum-l-and-development-of-web-genomic-resources
#18
Sarika Jaiswal, Tushar J Antala, M K Mandavia, Meenu Chopra, Rahul Singh Jasrotia, Rukam S Tomar, Jashminkumar Kheni, U B Angadi, M A Iquebal, B A Golakia, Anil Rai, Dinesh Kumar
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
May 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29750248/physician-preparedness-for-big-genomic-data-a-review-of-genomic-medicine-education-initiatives-in-the-united-states
#19
Caryn Kseniya Rubanovich, Cynthia Cheung, Jess Mandel, Cinnamon S Bloss
In the last decade, genomic medicine education initiatives have surfaced across the spectrum of physician training in order to help address a gap in genomic medicine preparedness among physicians. The approaches are diverse and stem from the belief that 21st century physicians must be proficient in genomic medicine applications as they will be leaders in the precision medicine movement. We conducted a review of literature in genomic medicine education and training for medical students, graduate medical education, and practicing physicians with articles published between June 2015 and January 2018 to gain a picture of the current state of genomic medicine education with a focus on the United States...
May 10, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29750058/australian-cardiac-rehabilitation-exercise-parameter-characteristics-and-perceptions-of-high-intensity-interval-training-a-cross-sectional-survey
#20
Amanda L Hannan, Wayne Hing, Mike Climstein, Jeff S Coombes, James Furness, Rohan Jayasinghe, Joshua Byrnes
Purpose: This study explored current demographics, characteristics, costs, evaluation methods, and outcome measures used in Australian cardiac rehabilitation (CR) programs. It also determined the actual usage and perceptions of high-intensity interval training (HIIT). Methods: A cross-sectional observational web-based survey was distributed to 328 Australian CR programs nationally. Results: A total of 261 programs completed the survey (79...
2018: Open Access Journal of Sports Medicine
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