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https://www.readbyqxmd.com/read/29145620/head-and-neck-cancer-in-hong-kong
#1
Wai Tong Ng, Edwin C Y Wong, Victor H F Lee, Jimmy Y W Chan, Anne W M Lee
Head and neck cancer is a major cause of morbidity and mortality in Hong Kong. HNC is well-known for its heterogeneity in epidemiology, clinical behavior, clinic-pathological features and patient characteristics. Treatment strategies for this heterogeneous disease vary greatly in different parts of the world, depending on availability of resources, local expertise and experience. Extensive research in head and neck cancer, particularly nasopharyngeal carcinoma, has been conducted in Hong Kong in the past few decades...
November 14, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29133573/the-rars-mad1l1-fusion-gene-induces-cancer-stem-cell-like-properties-and-therapeutic-resistance-in-nasopharyngeal-carcinoma
#2
Qian Zhong, Zhihua Liu, Zhi-Rui Lin, Ze-Dong Hu, Li Yuan, Yan-Min Liu, Ai-Jun Zhou, Li-Hua Xu, Li-Juan Hu, Zi-Feng Wang, Xin Yuan Guan, Jia-Jie Hao, Vivian Wai Yan Lui, Ling Guo, Hai-Qiang Mai, Ming-Yuan Chen, Fei Han, Yun-Fei Xia, Jennifer R Grandis, Xing Zhang, Mu-Sheng Zeng
PURPOSE: Nasopharyngeal carcinoma (NPC) is most common head and neck cancer in Southeast Asia. Because local recurrence and distant metastasis are still the main causes of NPC treatment failure, it is urgent to identify new tumor markers and therapeutic targets for advanced NPC. EXPERIMENTAL DESIGN: RNA-seq was applied to look for interchromosome translocation in NPC. PCR, FISH and immunoprecipitation were used to examine the fusion gene expression at RNA, DNA, and protein levels in NPC biopsies...
November 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29100787/facility-volume-and-survival-in-nasopharyngeal-carcinoma
#3
Emi J Yoshida, Michael Luu, John M David, Sungjin Kim, Alain Mita, Kevin Scher, Stephen L Shiao, Mourad Tighiouart, Nancy Y Lee, Allen S Ho, Zachary S Zumsteg
INTRODUCTION: Definitive treatment of nasopharyngeal carcinoma (NPC) is challenging owing to its rarity, complicated regional anatomy, and the intensity of therapy. In contrast to other head and neck cancers, the effect of facility volume has not been well described for NPC. METHODS AND MATERIALS: The National Cancer Database was queried for patients with stage II-IVB NPC diagnosed from 2004 to 2014 and treated with definitive radiation. Patients with incomplete staging, unknown receipt or timing of treatment, unknown follow-up duration, incomplete socioeconomic information, or treatment outside the reporting facility were excluded...
September 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29098554/seom-clinical-guideline-in-nasopharynx-cancer-2017
#4
M Pastor, A Lopez Pousa, E Del Barco, P Perez Segura, B Gonzalez Astorga, B Castelo, T Bonfill, J Martinez Trufero, J Jose Grau, R Mesia
Nasopharyngeal carcinoma (NPC) is distinct from other cancers of the head and neck in biology, epidemiology, histology, natural history, and response to treatment. Radiation therapy is an essential component of curative-intent of non-disseminated disease and the association of chemotherapy improves the rates of survival. In the case of metastatic disease stages, treatment requires platinum/gemcitabine-based chemotherapy and patients may achieve a long survival time.
November 2, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29053029/the-evidence-on-effectiveness-of-weekly-vs-triweekly-cisplatin-concurrent-with-radiotherapy-in-locally-advanced-head-and-neck-squamous-cell-carcinoma-hnscc-a-systematic-review-and-meta-analysis
#5
REVIEW
Jc Kennetth Jacinto, Jayson Co, Michael Benedict Mejia, Eugenio Emmanuel Regala
OBJECTIVE: This study aims to synthesize the current available evidences on the effectiveness of weekly vs triweekly cisplatin concurrent with radiotherapy in the primary and adjuvant treatment of locally advanced head and neck squamous cell carcinoma (HNSCC). METHODS: A systematic review and meta-analysis of literature were undertaken to assess the effectiveness of weekly vs triweekly schedule in primary and adjuvant treatment for HNSCC with adverse risk features...
November 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29049342/association-between-a-mirna-146a-polymorphism-and-susceptibility-to-head-and-neck-squamous-cell-carcinoma-in-chinese-patients-a-meta-analysis-of-8-case-control-studies
#6
Silin Zhang, Fangling Hu, Hongxing Liang, Yuanzhou Liu, Jianqiang Yang, Wensheng Zhou
A closer association has been found between the microRNA-146a rs2910164 polymorphism and the risk of head and neck carcinoma in some molecular epidemiological studies. Recently two meta-analyses were performed to explore the relationship between miRNA-146a polymorphisms and the susceptibility of squamous cell carcinoma of the head and neck (SCCHN); however, they yielded conflicting results in susceptibility regarding ethnic variations. Hence, the present study was performed to explain the relationship between the miRNA-146a rs2910164 polymorphism and the risk of SCCHN development of Chinese patients...
2017: PloS One
https://www.readbyqxmd.com/read/29025723/setting-the-stage-for-2018-how-the-changes-in-the-american-joint-committee-on-cancer-union-for-international-cancer-control-cancer-staging-manual-eighth-edition-impact-radiologists
#7
C M Glastonbury, S K Mukherji, B O'Sullivan, W M Lydiatt
The updated eighth edition of the Cancer Staging Manual of the American Joint Committee on Cancer will be implemented in January 2018. There are multiple changes to the head and neck section of the manual, which will be relevant to radiologists participating in multidisciplinary head and neck tumor boards and reading pretreatment head and neck cancer scans. Human papillomavirus-related/p16(+) oropharyngeal squamous cell carcinoma will now be staged separately; this change reflects the markedly better prognosis of these tumors compared with non-human papillomavirus/p16(-) oropharyngeal squamous cell carcinoma...
October 12, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28990103/silver-nanoparticles-coupled-to-anti%C3%A2-egfr-antibodies-sensitize-nasopharyngeal-carcinoma-cells-to-irradiation
#8
Dahai Yu, Yan Zhang, Hong Lu, Di Zhao
Radiotherapy is the major form of treatment for head and neck carcinoma, a malignant tumour of epithelial origin. The identification of agents, which can be co‑administered in order to sensitize these tumours to radiotherapy, has become a major focus of investigations. In the present study, a novel 20 nm nanocomposite, Ag/C225, was constructed, which consisted of silver nanoparticles (AgNPs) conjugated to an epidermal growth factor receptor‑specific antibody (C225). Physical characterization demonstrated that the Ag/C225 nanoparticles were spherical and dispersed well in water...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28975121/epidemiology-and-outcomes-of-nasopharyngeal-carcinoma-experience-from-a-regional-cancer-center-in-southern-india
#9
Rudresha Antapura Haleshappa, Aditi Harsh Thanky, Lakshmaiah Kuntegowdanahalli, Govind Babu Kanakasetty, Lokanatha Dasappa, Linu Jacob
CONTEXT: Nasopharyngeal carcinoma (NPC) is a rare head and neck cancer with significant geographical variation. There are limited data on epidemiology and outcomes of NPC reported from Southern India. SETTINGS AND DESIGN: Retrospective analysis. MATERIALS AND METHODS: We analyzed our hospital data between January 2005 and December 2011 with NPC and analyzed their demographic parameters and outcomes with therapy. RESULTS: A total 143 cases of NPC were identified...
July 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28947213/high-expression-of-ki-67-acts-a-poor-prognosis-indicator-in-locally-advanced-nasopharyngeal-carcinoma
#10
Yajie Zhao, Lin Shen, Xinqiong Huang, Di Jing, David Huang, Jun Fu, Zhanzhan Li, Guangying Zhang, Liangfang Shen
Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy in Southern China and Southeast Asia compared with Western countries. The standard treatment for NPC is radiotherapy. However, radioresistance remains a serious obstacle to satisfactory treatment, it can cause local recurrence and distant metastases in some patients after treatment by radiation. We retrospectively reviewed 108 NPC patients (7th AJCC Ⅲ-Ⅳa) who have received intensity modulated radiation therapy (IMRT) between August 2008 and January 2012 at Xiangya Hospital of Central South University...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28926591/no-evidence-for-the-presence-of-epstein-barr-virus-in-squamous-cell-carcinoma-of-the-mobile-tongue
#11
Torben Wilms, Gulfaraz Khan, Philip J Coates, Nicola Sgaramella, Robin Fåhraeus, Asma Hassani, Pretty S Philip, Lena Norberg Spaak, Luigi Califano, Giuseppe Colella, Katarina Olofsson, Christos Loizou, Renato Franco, Karin Nylander
Squamous cell carcinoma of the head and neck (SCCHN) comprises a large group of cancers in the oral cavity and nasopharyngeal area that typically arise in older males in association with alcohol/tobacco usage. Within the oral cavity, the mobile tongue is the most common site for tumour development. The incidence of tongue squamous cell carcinoma (TSCC) is increasing in younger people, which has been suggested to associate with a viral aetiology. Two common human oncogenic viruses, human papilloma virus (HPV) and Epstein-Barr virus (EBV) are known causes of certain types of SCCHN, namely the oropharynx and nasopharynx, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28893862/molecular-profile-of-nasopharyngeal-carcinoma-analysing-tumour-suppressor-gene-promoter-hypermethylation-by-multiplex-ligation-dependent-probe-amplification
#12
Marc Ooft, Jolique van Ipenburg, Rob van Loo, Rick de Jong, Cathy Moelans, Weibel Braunius, Remco de Bree, Paul van Diest, Senada Koljenović, Rob Baatenburg de Jong, Jose Hardillo, Stefan Willems
AIMS: To assess differences in methylation profiles, and thus pathogenesis, between Epstein-Barr virus (EBV)-positive and negative nasopharyngeal carcinomas (NPCs). Also, promoter hypermethylation is a common phenomenon in early carcinogenesis to inactivate tumour suppressor genes. Since epigenetic changes are reversible, the therapeutic application of methylation inhibitors could provide treatment options. METHODS: We evaluated promoter hypermethylation profiles of 22 common tumour suppressor genes in 108 NPCs using methylation-specific multiplex ligation-dependent probe amplification...
September 11, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28892580/correlation-of-quantitative-parameters-of-magnetic-resonance-perfusion-weighted-imaging-with-vascular-endothelial-growth-factor-microvessel-density-and-hypoxia-inducible-factor-1%C3%AE-in-nasopharyngeal-carcinoma-evaluation-on-radiosensitivity-study
#13
Y Hu, H E, X Yu, F Li, L Zeng, Q Lu, X Xi, L Shen
OBJECTIVES: To investigate the correlation of parameters of magnetic resonance perfusion-weighted imaging (MR-PWI) with the expression of vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1α (HIF-1α) and microvessel density (MVD) in nasopharyngeal carcinoma (NPC) so as to explore the value of predicting radiosensitivity. DESIGN: A prospective study. SETTING: Department of Head-and-neck radiotherapy in Hunan Cancer Hospital...
September 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28881764/detection-of-nasopharyngeal-carcinoma-susceptibility-with-single-nucleotide-polymorphism-analysis-using-next-generation-sequencing-technology
#14
Mu-Yun Wu, Shu-Jing Huang, Fan Yang, Xin-Tian Qin, Dong Liu, Ying Ding, Shu Yang, Xi-Cheng Wang
Nasopharyngeal carcinoma (NPC) is a head and neck cancer with high incidence in South China and East Asia. To provide a theoretical basis for NPC risk screening and early prevention, we conducted a meta-analysis of relevant literature on the association of single nucleotide polymorphisms (SNP)s with NPC susceptibility. Further, expression of 15 candidate SNPs identified in the meta-analysis was evaluated in a cohort of NPC patients and healthy volunteers using next-generation sequencing technology. Among the 15 SNPs detected in the meta-analysis, miR-146a (rs2910164, C>G), HCG9 (rs3869062, A>G), HCG9 (rs16896923, T>C), MMP2 (rs243865, C>T), GABBR1 (rs2076483, T>C), and TP53 (rs1042522, C>G) were associated with decreased susceptibility to NPC, while GSTM1 (+/DEL), IL-10 (rs1800896, A>G), MDM2 (rs2279744, T>G), MDS1-EVI1 (rs6774494, G>A), XPC (rs2228000, C>T), HLA-F (rs3129055, T>C), SPLUNC1 (rs2752903, T>C; and rs750064, A>G), and GABBR1 (rs29232, G>A) were associated with increased susceptibility to NPC...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28877959/prognostic-role-of-tumour-associated-macrophages-and-regulatory-t-cells-in-ebv-positive-and-ebv-negative-nasopharyngeal-carcinoma
#15
Marc L Ooft, Jolique A van Ipenburg, Maxime E Sanders, Mariette Kranendonk, Ingrid Hofland, Remco de Bree, Senada Koljenović, Stefan M Willems
AIMS: Tumour-associated macrophages (TAMs) and regulatory T cells (Tregs) form a special niche supporting tumour progression, and both correlate with worse survival in head and neck cancers. However, the prognostic role of TAM and Tregs in nasopharyngeal carcinoma (NPC) is still unknown. Therefore, we determined differences in TAMs and Tregs in different NPC subtypes, and their prognostic significance. METHODS: Tissue of 91 NPCs was assessed for TAMs and Tregs by determination of CD68, CD163, CD206 and FOXP3 expression in the tumour microenvironment...
September 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28870086/histogram-analysis-of-apparent-diffusion-coefficient-maps-for-the-differentiation-between-lymphoma-and-metastatic-lymph-nodes-of-squamous-cell-carcinoma-in-head-and-neck-region
#16
Yan-Jun Wang, Xiao-Quan Xu, Hao Hu, Guo-Yi Su, Jie Shen, Hai-Bin Shi, Fei-Yun Wu
Background To clarify the nature of cervical malignant lymphadenopathy is highly important for the diagnosis and differential diagnosis of head and neck tumors. Purpose To investigate the role of first-order apparent diffusion coefficient (ADC) histogram analysis for differentiating lymphoma from metastatic lymph nodes of squamous cell carcinoma (SCC) in the head and neck region. Material and Methods Diffusion-weighted imaging (DWI) data of 67 patients (lymphoma, n = 20; SCC, n = 47) with malignant lymphadenopathy were retrospectively analyzed...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28867748/higher-incidence-of-nasopharyngeal-carcinoma-in-some-regions-in-the-world-confers-for-interplay-between-genetic-factors-and-external-stimuli
#17
Nabanita Roy Chattopadhyay, Piyanki Das, Koustav Chatterjee, Tathagata Choudhuri
Nasopharyngeal carcinoma (NPC) is a rare variety of head and neck cancers. The risk factors include three major causes: genetic factors, viral infection, and environmental and dietary factors. The types of NPC show strong ethnic and geographic variations. The keratinizing and non-keratinizing types are prevalent in the lower incidence regions like North America and Europe; whereas the undifferentiated type is mostly found in the regions with higher incidences like China, North Africa, Arctic, and Nagaland of North-East India...
2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28866730/egfr-targeted-therapies-in-the-post-genomic-era
#18
Mary Jue Xu, Daniel E Johnson, Jennifer R Grandis
Over 90% of head and neck cancers overexpress the epidermal growth factor receptor (EGFR). In diverse tumor types, EGFR overexpression has been associated with poorer prognosis and outcomes. Therapies targeting EGFR include monoclonal antibodies, tyrosine kinase inhibitors, phosphatidylinositol 3-kinase (PI3K) inhibitors, and antisense gene therapy. Few EGFR-targeted therapeutics are approved for clinical use. The monoclonal antibody cetuximab is a Food and Drug Administration (FDA)-approved EGFR-targeted therapy, yet has exhibited modest benefit in clinical trials...
September 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28864403/clinical-outcomes-of-several-imrt-techniques-for-patients-with-head-and-neck-cancer-a-propensity-score-weighted-analysis
#19
MULTICENTER STUDY
Jean-Emmanuel Bibault, Sophie Dussart, Pascal Pommier, Magali Morelle, Marius Huguet, Pierre Boisselier, Bernard Coche-Dequeant, Marc Alfonsi, Etienne Bardet, Michel Rives, Valentin Calugaru, Enrique Chajon, Georges Noel, Hinda Mecellem, Stephanie Servagi Vernat, Lionel Perrier, Philippe Giraud
PURPOSE: The Advanced Radiotherapy Oto-Rhino-Laryngologie (ART-ORL) study (NCT02024035) was performed to prospectively evaluate the clinical and economic aspects of helical TomoTherapy and volumetric modulated arc therapy (RapidArc, Varian Medical Systems, Palo Alto, CA) for patients with head and neck cancer. METHODS AND MATERIALS: Fourteen centers participated in this prospective comparative study. Randomization was not possible based on the availability of equipment...
November 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28821277/the-feasibility-analysis-of-omission-of-elective-irradiation-to-level-ib-lymph-nodes-in-low-risk-nasopharyngeal-carcinoma-based-on-the-2013-updated-consensus-guideline-for-neck-nodal-levels
#20
Xiaomin Ou, Yibing Miao, Xiaoshen Wang, Jianhui Ding, Xiayun He, Chaosu Hu
BACKGROUND: Level IB metastasis is rare in nasopharyngeal carcinoma (NPC). The purpose of this study is to investigate the high-risk factors for level IB metastasis and evaluate the feasibility of omission of elective irradiation to level IB in the low-risk subgroups in NPC. METHODS: This retrospective study identified 532 patients with NPC treated by definitive radiation in our institution from 2009 to 2010. Level IB nodes were electively irradiated based on the physician's decision...
August 18, 2017: Radiation Oncology
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