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https://www.readbyqxmd.com/read/28184180/serum-proteomic-based-analysis-identifying-autoantibodies-against-prdx2-and-prdx3-as-potential-diagnostic-biomarkers-in-nasopharyngeal-carcinoma
#1
Lie-Hao Lin, Yi-Wei Xu, Li-Sheng Huang, Chao-Qun Hong, Tian-Tian Zhai, Lian-Di Liao, Wen-Jie Lin, Li-Yan Xu, Kai Zhang, En-Min Li, Yu-Hui Peng
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a major head and neck cancer with high occurrence in Southeast Asia and southern China. We aimed to identify autoantibodies that may contribute to early detection of NPC. METHODS: We used serological proteome analysis to identify candidate autoantibodies against tumor-associated antigens. Levels of autoantibodies and Epstein-Barr virus capsid antigen-IgA (VCA-IgA) were measured by ELISA in 129 patients with NPC and 100 normal controls...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28169592/revisiting-induction-chemotherapy-before-radiotherapy-for-head-and-neck-cancer-part-i-carcinoma-of-non-nasopharyngeal-sites
#2
Christopher H Chapman, Upendra Parvathaneni, Sue S Yom
No abstract text is available yet for this article.
March 2017: Future Oncology
https://www.readbyqxmd.com/read/28169580/revisiting-induction-chemotherapy-before-radiotherapy-for-head-and-neck-cancer-part-ii-nasopharyngeal-carcinoma
#3
Christopher H Chapman, Upendra Parvathaneni, Sue S Yom
No abstract text is available yet for this article.
March 2017: Future Oncology
https://www.readbyqxmd.com/read/28152511/concurrent-chemoradiotherapy-degrades-the-quality-of-life-of-patients-with-stage-ii-nasopharyngeal-carcinoma-as-compared-to-radiotherapy
#4
Xin-Bin Pan, Shi-Ting Huang, Kai-Hua Chen, Yan-Ming Jiang, Jia-Lin Ma, Song Qu, Ling Li, Long Chen, Xiao-Dong Zhu
The purpose of this study was to compare the quality of life (QoL) of stage II nasopharyngeal carcinoma (NPC) patients treated with radiotherapy (RT) versus concurrent chemoradiotherapy (CCRT). In a cross-sectional study, these patients were treated with RT (n = 55) or CCRT (n = 51) between June 2008 and June 2013. For all subjects, disease-free survival was more than 3 years. QoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) questions and the Head and Neck 35 (EORTC QLQ-H&N35) questions...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28111039/-current-events-in-immunotherapy-for-upper-aerodigestive-tract-cancer
#5
Sophie Outh-Gauer, Christophe Le Tourneau, Chloé Broudin, Florian Scotte, Hélène Roussel, Stéphane Hans, Marion Mandavit, Eric Tartour, Cécile Badoual
Head and neck (HN) carcinomas (mostly represented by squamous cell carcinomas [SCC]) still have a poor prognosis, which could be dramatically improved with immunotherapy. Tumor's microenvironment changes, caused by many endogenous or exogenous events, can correlate with prognosis and therapeutic response. Here, we review recent data regarding HNSCC, nasopharyngeal carcinomas (NPC) and salivary gland malignant tumors, all three being potential target of immunotherapies. About half of HNSCC exhibit PD-L1 expression, this expression being upregulated in HPV-positive tumors...
February 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/28109073/cyclin-dependent-kinase-inhibitor-3-promotes-cancer-cell-proliferation-and-tumorigenesis-in-nasopharyngeal-carcinoma-by-targeting-p27
#6
Huimin Wang, Hexin Chen, Hang Zhou, Wenfa Yu, Zhenmin Lu
Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy with high invasion which arises from the nasopharynx epithelium. Cyclin-dependent kinase inhibitor 3 (CDKN3) belongs to the dual-specificity protein phosphatase family which plays a key role in regulating cell division. Abnormal expression of CDKN3 has been found in numerous types of cancer. In the current study, we explored the possible role of CDKN3 in cell proliferation, invasion ability and radiosensitivity in NPC cells. We reported that CDKN3 was upregulated and P27 was downregulated in NPC tissues and associated with worse patient prognosis...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28098136/exome-and-genome-sequencing-of-nasopharynx-cancer-identifies-nf-%C3%AE%C2%BAb-pathway-activating-mutations
#7
Yvonne Y Li, Grace T Y Chung, Vivian W Y Lui, Ka-Fai To, Brigette B Y Ma, Chit Chow, John K S Woo, Kevin Y Yip, Jeongsun Seo, Edwin P Hui, Michael K F Mak, Maria Rusan, Nicole G Chau, Yvonne Y Y Or, Marcus H N Law, Peggy P Y Law, Zoey W Y Liu, Hoi-Lam Ngan, Pok-Man Hau, Krista R Verhoeft, Peony H Y Poon, Seong-Keun Yoo, Jong-Yeon Shin, Sau-Dan Lee, Samantha W M Lun, Lin Jia, Anthony W H Chan, Jason Y K Chan, Paul B S Lai, Choi-Yi Fung, Suet-Ting Hung, Lin Wang, Ann Margaret V Chang, Simion I Chiosea, Matthew L Hedberg, Sai-Wah Tsao, Andrew C van Hasselt, Anthony T C Chan, Jennifer R Grandis, Peter S Hammerman, Kwok-Wai Lo
Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer characterized by Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The scarcity of NPC genomic data hinders the understanding of NPC biology, disease progression and rational therapy design. Here we performed whole-exome sequencing (WES) on 111 micro-dissected EBV-positive NPCs, with 15 cases subjected to further whole-genome sequencing (WGS), to determine its mutational landscape. We identified enrichment for genomic aberrations of multiple negative regulators of the NF-κB pathway, including CYLD, TRAF3, NFKBIA and NLRC5, in a total of 41% of cases...
January 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28070838/late-toxicity-evolving-radiotherapy-techniques-and-quality-of-life-in-nasopharyngeal-carcinoma
#8
Luciana Lastrucci, Silvia Bertocci, Vittorio Bini, Simona Borghesi, Roberta De Majo, Andrea Rampini, Paola Pernici, Pietro Giovanni Gennari
PURPOSE: To analyze quality of life (QoL) and functional state (FS) by patient-reported outcome (PRO) questionnaires (FACT-G, FACT-NP, PSS-HN, XeQOLS, and EQ-5D-3L) in long-term survivors nasopharyngeal carcinoma (NPC) treated with conventional radiotherapy (RT) and intensity modulated radiotherapy (IMRT). METHODS: 25 patients answered to five questionnaires about QoL and FS. All patients were assessed also for late toxicity. RESULTS: Functional Assessment of Cancer Therapy-General (FACT-G) and Performance Status Scale Head and Neck (PSS-HN) scores were significantly elevated (better QoL) in age <50 years (p = 0...
January 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28053597/mir-324-3p-suppresses-migration-and-invasion-by-targeting-wnt2b-in-nasopharyngeal-carcinoma
#9
Chao Liu, Guo Li, Nianting Yang, Zhongwu Su, Shuiting Zhang, Tengbo Deng, Shuling Ren, Shanhong Lu, Yongquan Tian, Yong Liu, Yuanzheng Qiu
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a malignant epithelial carcinoma of the head and neck with strong ability of invasion and metastasis. Our previous study indicated that miR-324-3p, as a tumor-suppressive factor, could regulate radioresistance of NPC cells by targeting WNT2B. The purpose of this study is to investigate the role of miR-324-3p on migration and invasion in NPC cells. METHODS: Quantitative real time PCR was applied to measure the expression level of miR-324-3p and WNT2B mRNA in both cells and tissues, and the expression level of WNT2B protein was determined by western blotting...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28048036/su-f-t-200-dosimetric-variation-of-organs-at-risk-for-recurrent-nasopharyngeal-carcinoma-rnpc-patients-treated-by-carbon-ion-beams
#10
W Wang, Y Sheng, K Shahnazi
PURPOSE: Investigate the factors which affect the doses of organs at risk (OARs) for head and neck carbon ion therapy. METHODS: Ten locally recurrent nasopharyngeal carcinoma cases with similar prescriptions were selected. All patients' organs at risk (OARs) as well as CTVs were contoured by an experienced physician. Carbon ion treatment plans were created using a Syngo treatment planning system (Siemens, Germany). The CTVs were expanded to make optimized target volumes (OTVs) by considering treatment uncertainties and OAR protections...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047866/su-f-t-357-dosimetric-comparison-of-automatic-imrt-planning-and-manual-imrt-plan-for-head-and-neck-cancer
#11
X Chang, K Li, W Hu
PURPOSE: The purpose of this study is to compare dosimetric differences of Auto-planning and manual IMRT plan and investigate the feasibility and efficiency of the Auto-planning in the nasopharyngeal carcinoma (NPC). METHODS: Ten patients with NPC treated were enrolled in this study. Two IMRT plans were generated for each patient: manually optimized clinical plan and the automatically optimized plan using the Pinnacle Auto-planning (Auto plan). All the plan parameters such as gantry angle, the maximum number of iterations, the maximum number of control points, minimum segment MU and area are same, except the optimization method...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28001329/fna-biopsy-of-secondary-nonlymphomatous-malignancies-in-salivary-glands-a-multi-institutional-study-of-184-cases
#12
He Wang, Raza S Hoda, William Faquin, Esther Diana Rossi, Nihar Hotchandani, Tianlin Sun, Marc Pusztaszeri, Tommaso Bizzarro, Massimo Bongiovanni, Viren Patel, Nirag Jhala, Guido Fadda, Yun Gong
BACKGROUND: Secondary malignancies of salivary glands (SMSGs) are among the most common malignant neoplasms to involve the salivary glands. Fine-needle aspiration biopsy (FNAB) of SMSG can present diagnostic challenges. The current report presents the largest such FNAB series to date. METHODS: A search of the pathology database from 6 academic institutions identified 184 FNAB cases of nonlymphomatous SMSG. RESULTS: Of the 184 cases, 171 were of the parotid glands, and 13 were of the submandibular glands; 130 patients were men, and 54 were women, and the mean patient age at diagnosis was 68 years...
December 21, 2016: Cancer
https://www.readbyqxmd.com/read/27997061/use-of-pretreatment-serum-uric-acid-level-to-predict-metastasis-in-locally-advanced-nasopharyngeal-carcinoma
#13
Xiao-Jing Du, Lei Chen, Wen-Fei Li, Ling-Long Tang, Yan-Ping Mao, Rui Guo, Ying Sun, Ai-Hua Lin, Jun Ma
BACKGROUND: The purpose of this study was to determine the predictive value of pretreatment serum uric acid (SUA) for metastasis in locally advanced nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy. METHODS: This retrospective study examined 1063 patients with locally advanced NPC. Multivariate survival analysis was used. RESULTS: High pretreatment SUA level (>353.4 μmol/L) independently predicted distant metastasis-free survival (p = ...
December 20, 2016: Head & Neck
https://www.readbyqxmd.com/read/27901642/a-generic-rna-pulsed-dc-based-approach-for-developing-therapeutic-intervention-against-nasopharyngeal-carcinoma
#14
Rajeev K Tyagi, Rajesh Parmar, Naisargee Patel
The recurrent nasopharyngeal carcinoma of head-and-neck cancers pathology showed unique symptoms and clinical characteristics. The complexity of pathology poses challenges for developing therapeutic interventional approaches against nasopharyngeal carcinoma (NPC). The conventional treatment regimens offer limited local control and survival, which, leads to adverse delayed complications. Our study present a generic monocyte derived dendritic cell (MoDC) vaccine strategy for NPC in which RNA is used as a source of tumor-associated antigens (TAAgs)...
November 30, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27900042/antitumor-activity-of-7rh-a-discoidin-domain-receptor-1-inhibitor-alone-or-in-combination-with-dasatinib-exhibits-antitumor-effects-in-nasopharyngeal-carcinoma-cells
#15
Qiu-Ping Lu, Wen-Dan Chen, Jie-Ren Peng, Yao-Dong Xu, Qian Cai, Gong-Kan Feng, Ke Ding, Xiao-Feng Zhu, Zhong Guan
Dysregulation of the discoidin domain receptors (DDRs) has been implicated in the development of numerous types of tumors, including head and neck cancer, and nasopharyngeal, breast, ovarian and esophageal carcinomas. Furthermore, agents that inhibit DDR1 activity are hypothesized to be useful for the treatment of nasopharyngeal carcinoma (NPC). The aim of the present study was to evaluate the effect of the DDR1 inhibitory (3-(2-(pyrazolo(1,5-a)pyrimidin-6-yl)-ethynyl)benzamide compound, 7RH, in NPC cells both in vitro and in vivo, and its effect when used in combination with dasatinib, a SRC family kinase (SFK) inhibitor...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27898191/reirradiation-with-intensity-modulated-radiotherapy-for-locally-recurrent-t3-to-t4-nasopharyngeal-carcinoma
#16
Oscar S H Chan, Henry C K Sze, Michael C H Lee, Lucy L K Chan, Amy T Y Chang, Sarah W M Lee, Wai Man Hung, Anne W M Lee, Wai Tong Ng
BACKGROUND: The purpose of this study was to assess the efficacy and toxicities of reirradiation using intensity-modulated radiotherapy (IMRT) in patients with locally advanced recurrent nasopharyngeal carcinoma (NPC). METHODS: Thirty-eight patients with consecutive rT3 to rT4 NPC treated between 2005 and 2013 were retrospectively analyzed. RESULTS: The 3-year overall survival (OS), progression-free survival (PFS), and local control rate were 47...
November 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/27833652/molecular-detection-of-epstein-barr-virus-in-nasopharyngeal-carcinoma-among-sudanese-population
#17
Ali Edreis, Mona Ali Mohamed, Nouh S Mohamed, Emmanuel E Siddig
BACKGROUND: Nasopharyngeal carcinoma (NPC) is the most common cancer arising from the nasopharynx that varies significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. NPC caused by an interaction between infection with EBV and environmental and genetic factors, encompasses a multistep oncogenic process. The frequency of Epstein-Barr virus EBV among nasopharyngeal carcinoma is well known worldwide, however, in the Sudan there is barely a published data...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27828863/the-clinical-characteristics-of-secondary-primary-tumors-in-patients-with-nasopharyngeal-carcinoma-after-intensity-modulated-radiotherapy-a-retrospective-analysis
#18
Wei Zhao, Hao Lei, Xiaodong Zhu, Ling Li, Song Qu, Xia Liang, Xiao Wang
To investigate the clinical characteristics associated with the risk of developing secondary primary tumors (SPTs) in patients with nasopharyngeal carcinoma (NPC) who underwent intensity-modulated radiotherapy (IMRT).Data from 527 patients with biopsy-proven nonmetastatic NPC who were treated with IMRT between January 2007 and December 2011 were analyzed retrospectively. The cumulative incidence of SPTs after IMRT completion was estimated using the Kaplan-Meier method. Intergroup differences in the cumulative incidence were determined using the log-rank test...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27761611/nasopharyngeal-carcinoma-in-a%C3%A2-low-incidence-european-area-a%C3%A2-prospective-observational-analysis-from-the-head-and-neck-study-group-of-the-italian-society-of-radiation-oncology-airo
#19
S Tonoli, D Alterio, O Caspiani, A Bacigalupo, F Bunkheila, M Cianciulli, A Merlotti, A Podhradska, M Rampino, D Cante, L Bruschieri, R Gatta, S M Magrini
PURPOSE: To evaluate the outcomes with respect to long-term survival and toxicity in patients with nasopharyngeal carcinoma (NPC) treated in a European country with low incidence. MATERIALS AND METHODS: A prospective observational study carried out by the AIRO Head and Neck group in 12 Italian institutions included 136 consecutive patients treated with radiotherapy (RT) ± chemotherapy (CHT) for NPC (without distant metastasis) between January 1, 2008 and December 31, 2010...
December 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27754332/tetrandrine-induces-apoptosis-of-human-nasopharyngeal-carcinoma-npc-tw-076-cells-through-reactive-oxygen-species-accompanied-by-an-endoplasmic-reticulum-stress-signaling-pathway
#20
Ya-Jing Lin, Shu-Fen Peng, Meng-Liang Lin, Chao-Lin Kuo, Kung-Wen Lu, Ching-Lung Liao, Yi-Shih Ma, Fu-Shin Chueh, Kuo-Ching Liu, Fu-Shun Yu, Jing-Gung Chung
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of the head and neck and the incidence is higher in Southeast Asia. Tetrandrine (TET) is a bisbenzylisoquinoline alkaloid, a natural product, and exhibits biological activities including action against many human cancer cell lines. However, the molecular mechanism of TET-induced cell apoptosis in human NPC cells is still unclear. In the present study, we investigated TET-induced apoptotic cell death and associated possible signal pathways on human nasopharyngeal carcinoma NPC-TW 076 cells in vitro...
October 12, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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