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Elena Bellosta Diago, Jesús Pérez-Pérez, Sonia Santos Lasaosa, Alejandro Viloria Alebesque, Saül Martínez-Horta, Jaime Kulisevsky, Javier López Del Val
Cardiovascular events are a major cause of early death in the Huntington's disease (HD) population. Dysautonomia as well as deterioration of circadian rhythms can be detected early in the disease progression and can have profound effects on cardiac health. The aim of the present study was to determine if HD patients and premanifest mutation carriers present a higher risk of cardiovascular disease (CVD) than non-mutation carrying controls METHODS: Prospective, cross-sectional, multicentre study of 38 HD mutation carriers (23 premanifest and 15 early-stage patients) compared to 38 age- and gender-matched healthy controls...
March 14, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Ramón C Hermida, Diana E Ayala, Artemio Mojón, José R Fernández
This trial investigated whether therapy with the entire daily dose of ≥1 hypertension medications at bedtime exerts a greater reduction in the risk of incident chronic kidney disease (CKD) than therapy with all medications upon awakening. We conducted a prospective, open-label, blinded endpoint trial of 2078 hypertensive patients without CKD (1017 men/1061 women, 53.6 ± 13.7 years of age) randomized to ingest all their prescribed hypertension medications upon awakening (n = 1041) or the entire daily dose of ≥1 of those medications at bedtime (n = 1037)...
March 12, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
John N Booth, Man Li, Daichi Shimbo, Rachel Hess, Marguerite R Irvin, Rick Kittles, James G Wilson, Lynn B Jorde, Alfred K Cheung, Leslie A Lange, Ethan M Lange, Yuichiro Yano, Paul Muntner, Adam P Bress
Background: African Americans have a higher prevalence of nocturnal hypertension and non-dipping blood pressure than European Americans, but the genetic contribution to these racial differences remains unclear. We assessed the association of the percentage West African genetic ancestry with nocturnal hypertension and non-dipping blood pressure in 932 African Americans from the Jackson Heart Study. Methods: Using percentage West African ancestry determined from 389 ancestry informative markers, participants were categorized into tertiles (Tertile 1 [low]: <79...
March 8, 2018: American Journal of Hypertension
Eugenia Gkaliagkousi, Panagiota Anyfanti, Sophia Chatzimichailidou, Areti Triantafyllou, Antonios Lazaridis, Spyros Aslanidis, Stella Douma
Predictors of adverse cardiovascular outcomes include elevated nighttime systolic blood pressure (SBP) and a non-dipping pattern. We investigated whether these factors correlate with systemic inflammation, cardiovascular risk, and markers of central and peripheral vascular damage in rheumatoid arthritis (RA), a disease characterized by excess cardiovascular risk. Twenty-four-hour ambulatory blood pressure monitoring was applied in patients and controls. Vascular assessments included measurement of arterial stiffness (pulse wave velocity) and carotid atherosclerosis (carotid intima-media thickness)...
March 9, 2018: Journal of Human Hypertension
Jonas Wuopio, Carl Johan Östgren, Toste Länne, Lars Lind, Toralph Ruge, Axel C Carlsson, Anders Larsson, Fredrik H Nyström, Johan Ärnlöv
BACKGROUND: Endostatin, cleaved from collagen XVIII in the extracellular matrix, is a promising circulating biomarker for cardiovascular damage. It possesses anti-angiogenic and anti-fibrotic functions and has even been suggested to be involved in blood pressure regulation. Less is known if endostatin levels relate to circadian blood pressure patterns. In the present paper we studied the association between circulating levels of endostatin and nocturnal dipping in blood pressure. METHODS: We used the CARDIPP-study, a cohort of middle aged, type 2 diabetics (n = 593, 32% women), with data on both 24-hour and office blood pressure, serum-endostatin, cardiovascular risk factors, and incident major cardiovascular events...
February 28, 2018: Blood Pressure
Lior Goldberg, Bat-El Bar-Aluma, Alex Krauthammer, Ori Efrati, Yehonatan Sharabi
OBJECTIVE: Familial dysautonomia (FD) is a rare genetic disease that involves extreme blood pressure fluctuations secondary to afferent baroreflex failure. The diurnal blood pressure profile, including the average, variability, and day-night difference, may have implications for long-term end organ damage. The purpose of this study was to describe the circadian pattern of blood pressure in the FD population and relationships with renal and pulmonary function, use of medications, and overall disability...
February 12, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
Tero J W Pääkkö, Juha S Perkiömäki, Y Antero Kesäniemi, Antti S Ylitalo, Jarmo A Lumme, Heikki V Huikuri, Olavi H Ukkola
Ambulatory blood pressure (ABP) has been shown to have an association with left ventricular hypertrophy (LVH). We evaluated the association between ABP characteristics and the development of LVH during long-term follow-up (20 years) in 420 middle-aged subjects from OPERA cohort. ABP measurements (ABPM) were recorded and echocardiographic examinations were performed at baseline and revisit. Anthropometrics were measured and laboratory analyses performed at visit. The questionnaire presented to all participants elicited detailed information about their habits...
February 7, 2018: Journal of Human Hypertension
Asadur Rahman, Arif Ul Hasan, Akira Nishiyama, Hiroyuki Kobori
The morning surge in blood pressure (BP) coincides with increased cardiovascular (CV) events. This strongly suggests that an altered circadian rhythm of BP plays a crucial role in the development of CV disease (CVD). A disrupted circadian rhythm of BP, such as the non-dipping type of hypertension (i.e., absence of nocturnal BP decline), is frequently observed in metabolic disorders and chronic kidney disease (CKD). The circadian timing system, controlled by the central clock in the suprachiasmatic nucleus of the hypothalamus and/or by peripheral clocks in the heart, vasculature, and kidneys, modulates the 24 h oscillation of BP...
January 30, 2018: International Journal of Molecular Sciences
Julie A Lovshin, Marko Škrtić, Petter Bjornstad, Rahim Moineddin, Denis Daneman, David Dunger, Heather N Reich, Farid H Mahmud, James W Scholey, David Z I Cherney, Etienne B Sochett
AIM: Adolescents with T1DM (type 1 diabetes mellitus) are at risk for hyperfiltration and elevated urinary albumin-to-creatinine ratio (ACR), which are early indicators of diabetic nephropathy. Adolescents with T1DM also develop early changes in blood pressure, cardiovascular structure and function. Our aims were to define the relationships between hyperfiltration, ACR, and 24-Hr ambulatory blood pressure over time in adolescents with T1DM. METHODS: Normotensive, normoalbuminuric adolescents (n=98) with T1DM underwent baseline and 2-year 24-Hr ambulatory blood pressure monitoring, glomerular filtration rate (eGFR) estimated by cystatin C (Larsson equation) and ACR measurements...
December 13, 2017: American Journal of Physiology. Renal Physiology
Lauren Grace Douma, Meaghan Rayann Holzworth, Kristen Solocinski, Sarah Howland Masten, Amber Holly Miller, Kit-Yan Cheng, I Jeanette Lynch, Brian D Cain, Charles S Wingo, Michelle L Gumz
Many physiological functions have a circadian rhythm, including blood pressure (BP). BP is highest during the active phase whereas during the rest period BP dips 10%-20%. Patients that do not experience this dip at night are termed "non-dippers." Non-dipping hypertension is associated with increased risk of cardiovascular disease. The mechanisms underlying non-dipping hypertension are not understood. Without the circadian clock gene Per1, C57BL/6J mice develop non-dipping hypertension on a high-salt diet plus mineralocorticoid treatment (HS/DOCP)...
January 10, 2018: American Journal of Physiology. Renal Physiology
N Zisapel
In mammals a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24h light-dark cycle to invigorate and optimize the internal temporal order. The SCN-activated, light- inhibited production of melatonin conveys the message of darkness to the clock and induces night state in physiological function, e.g., sleep/wake blood pressure and metabolism. Clinically meaningful effects of melatonin treatment have been demonstrated in placebo-controlled trials in humans, particularly in disorders associated with diminished or misaligned melatonin rhythms, e...
January 10, 2018: British Journal of Pharmacology
Hasan Ata Bolayır, Tarık Kıvrak, Hakan Gunes, Aslı Bolayır, Ilgın Karaca
BACKGROUND: Nocturnal hypertension and non-dipping pattern are often associated with endothelial dysfunction. Previous studies suggested that adropin, a novel secreted energy homeostasis protein, has unique effects to regulate endothelial cell function. AIM: This study aims to investigate the association between absolute nighttime blood pressure (BP) and circadian BP pattern with serum adropin and high-sensitivity C-reactive protein (hsCRP) levels in patients with newly diagnosed untreated hypertension...
January 9, 2018: Kardiologia Polska
J Schrader, B Schrader
Arterial hypertension is the most common modifiable risk factor for cerebrovascular and cardiovascular morbidity and mortality in old age. The prevention of cognitive brain disorders is also a therapeutic goal of long-term treatment of hypertension. Older patients also have a higher risk of developing cardiovascular diseases and therefore benefit from a relatively moderate reduction in blood pressure. With respect to the high prevalence of hypertension in old age and the increasing incidence with time, the therapy of hypertension is becoming increasingly more important to achieve an improved prognosis for patients along with a reduction of costs...
November 29, 2017: Herz
A Ilic, D J Ilic, S Tadic, M Stefanovic, A Stojsic-Milosavljevic, K Pavlovic, A Redzek, L Velicki
BACKGROUND: An association between gestational hypertension (GH) and changes of maternal cardiac function was previously reported. AIM: The study assessed the effect of non-dipping pattern of blood pressure (BP) in GH on haemodynamic function and intrauterine growth restriction (IUGR). METHODS: This study included 126 women (91 with GH and 35 normotensive controls). Based on the BP values measured by ambulatory blood pressure monitoring (ABPM), all hypertensive women were classified in dipper (46 women) or in non-dipper group (45 women)...
October 2017: Pregnancy Hypertension
Dominika Klimczak, Marek Kuch, Tomasz Pilecki, Dorota Żochowska, Agnieszka Wirkowska, Leszek Pączek
MicroRNAs play multiple roles in the regulation of blood pressure (BP). Nevertheless, to date, no study has assessed the association between microRNA plasma expression and BP control in chronic kidney disease (CKD) patients. Given this background, we evaluated the plasma expression of miR-155-5p, a translational inhibitor of angiotensin receptor type I, in CKD patients, to determine the association between miR-155-5p level and BP control. In this single-center cross-sectional study, we analyzed the miR-155-5p concentration by quantitative reverse transcriptase polymerase chain reaction using the U6 snRNA as a reference gene and 24-hour ambulatory blood pressure monitoring in CKD patients (stage ≥2) in relation to a control group of healthy age-matched and gender-matched individuals, with normal BP proven by the ambulatory blood pressure monitoring...
December 2017: Journal of the American Society of Hypertension: JASH
Angelina Stevanovic, Milica Dekleva
The primary aims of this study have been to explore the diagnostic and prognostic significance of Tissue Doppler parameters (TDI), global longitudinal strain (GLS), and blood pressure (BP) pattern in normotensive diabetic patients. METHODS: The study consisted of 121 diabetic patients and 41 healthy subjects. Conventional and TDI echocardiography were performed on all patients, including E/Em (ratio of diastolic velocities). GLS was derived from two-dimensional speckle-tracking. Ambulatory BP monitoring (ABPM) was obtained over 24h...
September 18, 2017: Journal of Diabetes and its Complications
Rahime Renda
BACKGROUND: Obesity in adults has been related to hypertension and abnormal nocturnal dipping of blood pressure, which are associated with poor cardiovascular and renal outcomes. Here, we aimed to resolve the relationship between the degree of obesity, the severity of hypertension and dipping status on ambulatory blood pressure in obese children. METHODS: A total 72 patients with primary obesity aged 7 to 18 years (mean: 13.48 ± 3.25) were selected. Patients were divided into three groups based on body mass index (BMİ) Z-score...
October 24, 2017: Acta Clinica Belgica
Mariusz Sieminski, Kamil Chwojnicki, Tomi Sarkanen, Markku Partinen
STUDY OBJECTIVE: Narcolepsy type 1 (NT1) is caused by a deficiency or absence of the neurotransmitter orexin. NT1 is also associated with a reduced nocturnal "dipping" of blood pressure (BP). The study objective was to analyze whether nocturnal BP values differed in patients depleted of orexin, versus those in whom production was preserved. METHODS: We performed a retrospective analysis of the polysomnographic recordings, orexin levels, and BP values of patients with NT1...
2017: PloS One
Berrin Karadag, Tolga Ozyigit, Zeliha Serindag, Aysegul Ilhan, Beste Ozben
BACKGROUND: Target organ damage is important for global cardiovascular risk assessment. The aim of this study was to explore the association between the blood pressure profile and end-organ damage in a hypertensive non-diabetic cohort. METHODS: A total of 560 consecutive hypertensive nondiabetic patients (mean age: 58.2 ± 13.3 years, 221 men) were included in the study. All patients underwent thorough physical examination including fundoscopic examination. First morning urine samples were obtained from each patient and measurement of the albumin-to-creatinine ratio in first morning urine collection samples was used for diagnosis of microalbuminuria...
October 4, 2017: Wiener Klinische Wochenschrift
Hung-Ju Lin, Tzung-Dau Wang
No abstract text is available yet for this article.
September 2017: Acta Cardiologica Sinica
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