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https://www.readbyqxmd.com/read/29146158/plasma-microrna-155-5p-is-increased-among-patients-with-chronic-kidney-disease-and-nocturnal-hypertension
#1
Dominika Klimczak, Marek Kuch, Tomasz Pilecki, Dorota Żochowska, Agnieszka Wirkowska, Leszek Pączek
MicroRNAs play multiple roles in the regulation of blood pressure (BP). Nevertheless, to date, no study has assessed the association between microRNA plasma expression and BP control in chronic kidney disease (CKD) patients. Given this background, we evaluated the plasma expression of miR-155-5p, a translational inhibitor of angiotensin receptor type I, in CKD patients, to determine the association between miR-155-5p level and BP control. In this single-center cross-sectional study, we analyzed the miR-155-5p concentration by quantitative reverse transcriptase polymerase chain reaction using the U6 snRNA as a reference gene and 24-hour ambulatory blood pressure monitoring in CKD patients (stage ≥2) in relation to a control group of healthy age-matched and gender-matched individuals, with normal BP proven by the ambulatory blood pressure monitoring...
October 28, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29137850/the-importance-of-subclinical-left-ventricular-dysfunction-and-blood-pressure-pattern-in-asymptomatic-type-2-diabetic-patients-the-diagnostic-and-prognostic-significance-of-tissue-doppler-parameters-left-ventricular-global-longitudinal-strain-and-nighttime
#2
Angelina Stevanovic, Milica Dekleva
The primary aims of this study have been to explore the diagnostic and prognostic significance of Tissue Doppler parameters (TDI), global longitudinal strain (GLS), and blood pressure (BP) pattern in normotensive diabetic patients. METHODS: The study consisted of 121 diabetic patients and 41 healthy subjects. Conventional and TDI echocardiography were performed on all patients, including E/Em (ratio of diastolic velocities). GLS was derived from two-dimensional speckle-tracking. Ambulatory BP monitoring (ABPM) was obtained over 24h...
September 18, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29065792/comparison-of-ambulatory-blood-pressure-monitoring-and-office-blood-pressure-measurements-in-obese-children-and-adolescents
#3
Rahime Renda
BACKGROUND: Obesity in adults has been related to hypertension and abnormal nocturnal dipping of blood pressure, which are associated with poor cardiovascular and renal outcomes. Here, we aimed to resolve the relationship between the degree of obesity, the severity of hypertension and dipping status on ambulatory blood pressure in obese children. METHODS: A total 72 patients with primary obesity aged 7 to 18 years (mean: 13.48 ± 3.25) were selected. Patients were divided into three groups based on body mass index (BMİ) Z-score...
October 24, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29023559/the-relationship-between-orexin-levels-and-blood-pressure-changes-in-patients-with-narcolepsy
#4
Mariusz Sieminski, Kamil Chwojnicki, Tomi Sarkanen, Markku Partinen
STUDY OBJECTIVE: Narcolepsy type 1 (NT1) is caused by a deficiency or absence of the neurotransmitter orexin. NT1 is also associated with a reduced nocturnal "dipping" of blood pressure (BP). The study objective was to analyze whether nocturnal BP values differed in patients depleted of orexin, versus those in whom production was preserved. METHODS: We performed a retrospective analysis of the polysomnographic recordings, orexin levels, and BP values of patients with NT1...
2017: PloS One
https://www.readbyqxmd.com/read/28980066/blood-pressure-profile-is-associated-with-microalbuminuria-and-retinopathy-in-hypertensive-nondiabetic-patients
#5
Berrin Karadag, Tolga Ozyigit, Zeliha Serindag, Aysegul Ilhan, Beste Ozben
BACKGROUND: Target organ damage is important for global cardiovascular risk assessment. The aim of this study was to explore the association between the blood pressure profile and end-organ damage in a hypertensive non-diabetic cohort. METHODS: A total of 560 consecutive hypertensive nondiabetic patients (mean age: 58.2 ± 13.3 years, 221 men) were included in the study. All patients underwent thorough physical examination including fundoscopic examination. First morning urine samples were obtained from each patient and measurement of the albumin-to-creatinine ratio in first morning urine collection samples was used for diagnosis of microalbuminuria...
October 4, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28959102/nocturnal-non-dipping-an-overlooked-clinical-manifestation-of-subclinical-hypothyroidism-linking-to-increased-cardiovascular-risk
#6
EDITORIAL
Hung-Ju Lin, Tzung-Dau Wang
No abstract text is available yet for this article.
September 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28959101/evaluation-of-daily-blood-pressure-alteration-in-subclinical-hypothyroidism
#7
Ismail Polat Canbolat, Erdal Belen, Akif Bayyigit, Aysen Helvaci, Kadriye Kilickesmez
BACKGROUND: Subclinical hypothyroidism is the most common thyroid dysfunction in the general population. The relationship between overt thyroid dysfunction and hypertension is generally understood. Besides high blood pressure, non-dipper hypertension is known to increase cardiovascular risk. Our aim is to investigate daily blood pressure changes and the frequency of non-dipping patterns in patients with subclinical hypothyroidism. METHODS: Forty-nine patients without hypertension with subclinical hypothyroidism were compared with 50 healthy sex- and age-matched controls using ambulatory blood pressure monitoring...
September 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28935191/circadian-rhythm-and-autonomic-dysfunction-in-presymptomatic-and-early-huntington-s-disease
#8
Elena Bellosta Diago, Jesús Pérez Pérez, Sonia Santos Lasaosa, Alejandro Viloria Alebesque, Saül Martínez Horta, Jaime Kulisevsky, Javier López Del Val
INTRODUCTION: Sleep and circadian rhythm disturbances are common in patients with neurodegenerative diseases such as Huntington's disease (HD). The aim of this study was to evaluate variability in circadian blood pressure (BP) to determine the association between abnormal circadian BP and sleep quality in patients with HD. METHODS: Cross-sectional, multicenter study of 38 HD mutation carriers (23 premanifest and 15 early stage patients) who were compared to 38 age- and sex-matched controls...
September 15, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28931072/high-prevalence-of-non-dipping-blood-pressure-and-vascular-stiffness-in-hiv-infected-south-africans-on-antiretrovirals
#9
M S Borkum, J M Heckmann, K Manning, J A Dave, N S Levitt, B L Rayner, N Wearne
BACKGROUND: HIV-infected individuals are at increased risk of tissue inflammation and accelerated vascular aging ('inflamm-aging'). Abnormal diurnal blood pressure (BP) rhythms such as non-dipping may contribute to an increased risk of cardiovascular and cerebrovascular events in HIV infected individuals. However, little data exists on ambulatory blood pressure (ABP) and measures of vascular stiffness in the black African HIV infected population. METHODS: This is a cross-sectional analysis of otherwise well, HIV infected outpatients on ART for >5 years...
2017: PloS One
https://www.readbyqxmd.com/read/28853425/obstructive-sleep-apnea-syndrome-osas-and-cardiovascular-system
#10
Carolina Lombardi, Eleonora Tobaldini, Nicola Montano, Anna Losurdo, Gianfranco Parati
There is increasing evidence of a relationship between Obstructive Sleep Apnea (OSA) and cardiovascular diseases. The strong association between OSA and arterial hypertension, in particular in patients with resistant hypertension and/or a non-dipping profile, has been extensively reported. The relationship between OSA and high blood pressure (BP) has been found independent from a number of confounders, but several factors may affect this relationship, including age and sex. It is thus important to better assess pathophysiologic and clinical interactions between OSA and arterial hypertension, also aimed at optimizing treatment approaches in OSA and hypertensive patients with co-morbidities...
August 28, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28816976/comparison-of-ambulatory-blood-pressure-and-clinic-blood-pressure-in-relation-to-cardiovascular-diseases-in-diabetic-patients
#11
Jian Shen, Zhi-Ming Li, Li-Zhen He, Ren-Sheng Deng, Jing-Guang Liu, Yuan-Sheng Shen
The aim of this study was to evaluate prognostic values of ambulatory blood pressure (ABP) and clinic blood pressure (CBP) in diabetic patients with hypertension. A total of 450 diabetic hypertensive patients without established cardiovascular diseases were enrolled and 416 patients who had finished 12months' follow-up were included in final analysis. Baseline data were collected and Cox proportional hazards regression analysis was used to evaluate prognostic value of ABP and CBP. Compared to those without study endpoints (n = 370), those experienced study endpoints (n = 46) were more elderly and more likely to be male, and had longer hypertension duration (7...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28783384/clinical-physical-physiological-and-dietary-patterns-of-obese-and-sedentary-adults-with-primary-hypertension-characterized-by-sex-and-cardiorespiratory-fitness-exerdiet-hta-study
#12
Ilargi Gorostegi-Anduaga, Pablo Corres, Borja Jurio-Iriarte, Aitor Martínez-Aguirre, Javier Pérez-Asenjo, Gualberto R Aispuru, Lide Arenaza, Estibaliz Romaratezabala, Iñaki Arratibel-Imaz, Iñigo Mujika, Silvia Francisco-Terreros, Sara Maldonado-Martín
The main purpose of this study was to determine some key physical, physiological, clinical, and nutritional markers of health status in obese and sedentary adults (54.0 ± 8.1 years, 141 men and 68 women) with primary hypertension (HTN) characterized by sex and cardiorespiratory fitness (CRF) level. The studied population showed a high cardiovascular risk (CVR) profile including metabolically abnormal obese, with poor CRF level (22.5 ± 5.6 mL·kg(-1)·min(-1)), exercise-induced HTN (Systolic Blood Pressure>210 mmHg in men and >190 mmHg in women at the end of the exercise test) and with non-healthy adherence to dietary pattern (Dietary Approaches to Stop Hypertension, 46...
August 7, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28768228/preeclampsia-is-associated-with-increased-ambulatory-arterial-stiffness-index-in-type-1-diabetes-mellitus
#13
Hanine F M Al-Far, Ingvild H Tjessem, Jens Fuglsang, Finn F Lauszus
INTRODUCTION: Treatment of mild to moderate hypertension might not benefit maternal or fetal outcome. This pessimistic point of view may have come about by using non-validated methods for measuring blood pressure in pregnancy combined with inadequate methodology for diagnosis, treatment, and monitoring effects. AIM: To determine the association between AASI in women with type 1 diabetes mellitus (T1DM) and preeclampsia, and to assess the ability of AASI to diagnose preeclampsia...
July 25, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28754607/reversal-of-nocturnal-non-dipping-of-blood-pressure-after-levothyroxine-therapy-in-patients-with-subclinical-hypothyroidism
#14
Mannmath Nath, Balram Gupta, Madhukar Rai, Surya K Singh
AIMS: To study the loss of diurnal variation in blood pressure in normotensive patients with Subclinical/overt hypothyroidism and effect of Levothyroxine (L-T4) treatment. MATERIALS AND METHODS: In this interventional study Eighty patients between 17- 50 years with newly detected OH and SCH (74 women and 6 men) and nine euthyroid subjects (all men) with blood pressure <140/90 were recruited. All patients underwent 24h ambulatory blood pressure monitoring (ABPM) using ABPM machine before and after treatment with L-T4...
July 20, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28698994/prognostic-importance-of-sodium-level-trajectory-in-acute-heart-failure
#15
Yuya Matsue, Kenji Yoshioka, Makoto Suzuki, Sho Torii, Satoshi Yamaguchi, Seiji Fukamizu, Yuichi Ono, Hiroyuki Fujii, Takeshi Kitai, Toshihiko Nishioka, Kaoru Sugi, Yuko Onishi, Makoto Noda, Nobuyuki Kagiyama, Yasuhiro Satoh, Kazuki Yoshida, Steven R Goldsmith
Low sodium levels are strongly associated with poor prognosis in acute heart failure (AHF); however, the prognostic impact of the sodium level trajectory overtime has not been determined. A secondary analysis of the AQUAMARINE study in which patients with AHF and renal impairment were randomized to receive either tolvaptan or conventional treatment was performed. Sodium levels were evaluated at the baseline and at 6, 12, 24, and 48 h. We defined 'sodium dipping' as sodium level falling below the baseline level at any time point...
December 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28675304/immune-markers-diurnal-blood-pressure-profile-and-cardiac-function-in-virologically-suppressed-hiv-infected-patients
#16
Ingjerd W Manner, Bård Waldum-Grevbo, Birgit Nomeland Witczak, Morten Bækken, Olav Øktedalen, Ingrid Os, Thomas Schwartz, Ivar Sjaastad
PURPOSE: Non-dipping nocturnal blood pressure (BP) pattern has been reported prevalent among HIV-infected patients and is associated with adverse cardiovascular outcomes. The aims of this observational study were to identify predictors of nocturnal BP decline, and to explore whether diurnal BP profile is associated with alterations in cardiac structure and function. MATERIALS AND METHODS: A total of 108 treated HIV-infected patients with suppressed viremia underwent ambulatory BP measurement, 51 of these patients also underwent echocardiography...
July 4, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28636414/non-dipping-status-and-selected-adipokines-concentration-in-children-with-primary-arterial-hypertension
#17
Agnieszka Jędzura, Piotr Adamczyk, Omar Bjanid, Elżbieta Świętochowska, Dagmara Roszkowska-Bjanid, Anna Baraniecka, Beata Banaszak, Krzysztof Plesiński, Aurelia Morawiec-Knysak, Katarzyna Ziora, Maria Szczepańska
High blood pressure (BP) in children and adolescents is associated with increased risk of persistent hypertension (HT) in adulthood and, consequently, cardiovascular disease and target organ damage. AIM: The values of selected anthropometric parameters and laboratory test results including leptin and apelin concentration were evaluated with regard to averaged values of office BP measurements and 24-hour ABPM. MATERIAL AND METHODS: The study included 55 children: 23-with primary HT and coexisting overweight or obese (HT-OB), 16-with primary HT and normal weight (HT-NW), and 16 healthy children (C)...
June 21, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28557821/non-completion-of-nighttime-ambulatory-blood-pressure-monitoring-potential-for-selection-bias-in-analyses-of-non-dipping
#18
Kevin J Sundquist, Joseph E Schwartz, Donald Edmondson, Jennifer A Sumner
No abstract text is available yet for this article.
May 27, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28100918/cardioprotective-effects-of-sglt2-inhibitors-are-possibly-associated-with-normalization-of-the-circadian-rhythm-of-blood-pressure
#19
REVIEW
Asadur Rahman, Hirofumi Hitomi, Akira Nishiyama
Improvement in cardiovascular (CV) morbidity and mortality in the EMPA-REG OUTCOME study provides new insight into the therapeutic use of sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors in patients with type 2 diabetes. Although SGLT2 inhibitors have several pleiotropic effects, the underlying mechanism responsible for their cardioprotective effects remains undetermined. In this regard, the absence of a nocturnal fall in blood pressure (BP), that is, non-dipping BP, is a common phenomenon in type 2 diabetes and has a crucial role in the pathogenesis of CV morbidity and mortality...
June 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27920831/assessment-of-drug-induced-proarrhythmias-due-to-pilsicainide-in-patients-with-atrial-tachyarrhythmias
#20
Hideki Koike, Tadashi Fujino, Makiko Koike, Shintaro Yao, Masaya Shinohara, Ken Kitahara, Toshio Kinoshita, Hitomi Yuzawa, Takeya Suzuki, Hideyuki Sato, Shunji Fukunaga, Kenzaburo Kobayashi, Takanori Ikeda
BACKGROUND: Pilsicainide, a pure Na(+) channel blocker, is a popular antiarrhythmic drug for the management of atrial tachyarrhythmias (AT), in Japan. However, serious drug-induced proarrhythmias (DIPs) may unexpectedly occur. We assessed the clinical background of AT patients presenting with DIPs caused by pilsicainide. METHODS: This study retrospectively enrolled 874 consecutive patients (543 men, 63.6±15.3 years old, and 57.9±16.5 kg of body weight), who were orally administered pilsicainide for AT management...
December 2016: Journal of Arrhythmia
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