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Paul Kiondo, Gakenia Wamuyu-Maina, Julius Wandabwa, Gabriel S Bimenya, Nazarius Mbona Tumwesigye, Pius Okong
BACKGROUND: Oxidative stress plays a role in the pathogenesis of pre-eclampsia. Supplementing women with antioxidants during pregnancy may reduce oxidative stress and thereby prevent or delay the onset pre-eclampsia. The objective of this study was to evaluate the effect of supplementing vitamin C in pregnancy on the incidence of pre-eclampsia, at Mulago hospital, Kampala, Uganda. METHODS: This was a (parallel, balanced randomization, 1:1) placebo randomized controlled trial conducted at Mulago hospital, Department of Obstetrics and Gynecology...
2014: BMC Pregnancy and Childbirth
Gowri Sayi Prasad, Ashok Bhupali, Sayi Prasad, Ajit N Patil, Yashodhan Deka
OBJECTIVES: To study the pattern of presentation, course of disease and outcome of pregnancy in Peripartum Cardiomyopathy. METHODS: A prospective study of sixteen cases of PPCM was conducted at Apple Saraswati Multispecialty Hospital and Dr. D.Y. Patil Medical College and Hospital, Kolhapur, Maharashtra, India from January 2006 to December 2012. Data included age distribution, parity, gestational age, symptoms and risk factors. Medical management and pregnancy outcome were documented...
March 2014: Indian Heart Journal
B M Samaké, M Traoré, L Goita, M Niani, Y Traoré, I Teketé, A Diallo, A Dolo
AIMS: To determine the epidemio-clinical profile of severe pre-eclampsia. PATIENTS AND METHOD: It was about a transversal study done from November 2005 to juin 2006 at the teaching hospital Gabriel Touré. Were included pregnant women with severe pre-eclampsia. Statistical analysis compared the proportions and means, the proportions were compared using the chi (2 with) P < 0,05 considered significant. RESULTS: during the period of study, 130 cares of severe pré-eclamsia were brougthbto gether among 1667 pregnant women, which was 7,8 %...
2011: Le Mali Médical
Alfred K Mbah, Puza P Sharma, Amina P Alio, Doris W Fombo, Karen Bruder, Hamisu M Salihu
PURPOSE: We examine the association between prior C-section and subsequent pre-eclampsia; and describe the effect of gestational age at prior C-section, and obesity status on this association. METHODS: The study population included women with two subsequent singleton births in Missouri between 1998 and 2005. The risk for pre-eclampsia/eclampsia was assessed among women with and without prior cesarean delivery. The two groups were followed to their second pregnancy and the occurrence of pre-eclampsia was documented...
May 2012: Archives of Gynecology and Obstetrics
Aleksandra Novakov Mikic, Velibor Cabarkapa, Aleksandra Nikolic, Daniela Maric, Snezana Brkic, Gorana Mitic, Marina Ristic, Zoran Stosic
OBJECTIVE: To evaluate diagnostic value of cystatin C serum levels as alternative marker of renal function in pre-eclamsia (PE) and compare it with the traditional markers of renal function, creatinine and uric acid. In order to investigate the possible influence of inflammation on biochemical markers of renal function, serum levels of high sensitive CRP were measured (hsCRP). METHODS: In this prospective study markers of kidney function were investigated in two groups of pregnant women: one with PE (n = 32) and the other of healthy pregnant women (n = 60)...
July 2012: Journal of Maternal-fetal & Neonatal Medicine
Luci Maria Santana Dusse, Maria das Graças Carvalho, William Fialho Bragança, Sabrina Guimarães Paiva, Lara Carvalho Godoi, Daniela Amorim Melgaço Guimarães, Ana Paula Fernandes
OBJECTIVE: The aim of the present study was to compare the distribution of G1691A, G20210A and C677T mutations in pre-eclamptic Brazilian women and in matched control women with an uncomplicated normal pregnancy. STUDY DESIGN: these mutations were investigated by PCR-RFLP in 83 normal pregnancies (control group) and in 30 pre-eclamptic pregnant women (severe form). RESULTS: G1691A mutation was detected neither in the control group nor in pre-eclamsia women...
September 2007: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Rani Gupta, K N Maruthy, Arun M Mhaskar, Laxmi Devi Padmanabhan
The study was conducted in St. John's Medical College Hospital and Department of Physiology, with the aim of studying the serum nitrate levels in pre-eclampsia and normal pregnancy. The total number of subjects studied in various groups were 159, control (n = 55), first trimester (n = 13), second trimester normal (n = 42), second trimester pre-eclampsia/PET (n = 5), third trimester normal (n = 32), third trimester pre-eclampsia/PET (n = 12). The serum nitrate was measured by one step enzymatic assay using Nitrate reductase from Aspergillus species...
April 2003: Indian Journal of Physiology and Pharmacology
S Niromanesh, S Laghaii, A Mosavi-Jarrahi
OBJECTIVE: To study the effect of calcium supplementation on reduction of pre-eclampsia in Iranian women at high risk of pre-eclampsia. METHODS: Thirty pregnant women at high risk of developing pre-eclampsia were randomized to 2 g of daily calcium and placebo. Subjects and investigators were blinded to treatment allocation. The inclusion criteria were positive rollover test, having at least one risk factor for pre-eclampsia, between 28 and 32 weeks of pregnancy, and blood pressure less than 140/90 (mm Hg)...
July 2001: International Journal of Gynaecology and Obstetrics
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