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https://www.readbyqxmd.com/read/27933415/association-between-gamma-glutamyltransferase-and-albuminuria-in-nondiabetic-adults-with-normal-renal-function
#1
Sun-Hye Ko, Myong Ki Baeg, Kyung-Do Han, Seung-Yeon Ko, Sae-Bom Shin, Seung-Hyun Ko, Yu-Bae Ahn
BACKGROUND: Serum gamma-glutamyltransferase (GGT) has been associated with albuminuria in diabetes patients, but it has not been investigated in the general population. We aimed to investigate the association between serum GGT and albuminuria in the nondiabetic Korean population with normal kidney function. METHODS: Study participants (3948; 1549 men and 2399 women) with an estimated glomerular filtration rate ≥60 mL/min/1.73 m(2) were analyzed from the fifth Korean National Health and Nutrition Examination Survey (2011)...
December 9, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27924285/habit-of-eating-breakfast-is-associated-with-a-lower-risk-of-hypertension
#2
Tae Sic Lee, Jai Soon Kim, Yoo Jung Hwang, Yon Chul Park
BACKGROUND: The association between skipping breakfast and cardio-metabolic syndrome is well known. However, there are very few Korean studies about the habit of eating breakfast and hypertension. The present study aimed to investigate the relationship between the habit of eating breakfast and hypertension in a healthy Korean population. METHODS: Participants in the 2014 Korea National Health and Nutrition Examination Surveys (KNHANES) were enrolled for this study...
September 2016: Journal of Lifestyle Medicine
https://www.readbyqxmd.com/read/27923444/effects-of-a-culturally-adapted-lifestyle-intervention-on-cardio-metabolic-outcomes-a-randomized-controlled-trial-in-iraqi-immigrants-to-sweden-at-high-risk-for-type-2-diabetes
#3
Faiza Siddiqui, Azra Kurbasic, Ulf Lindblad, Peter M Nilsson, Louise Bennet
BACKGROUND AND AIMS: Middle-Eastern immigrants constitute a growing proportion of the Swedish population and are at high risk for Type 2 diabetes. This calls for a more proactive preventive approach for dealing with diabetes risk in this target group. The aim was to test the effect of a culturally adapted lifestyle intervention programme on changes in lifestyle habits and cardio-metabolic outcomes comparing an intervention group with a control group receiving usual care. METHODS: Citizens of Malmö, Sweden born in Iraq and at high risk for Type 2 diabetes (n=636) were invited...
January 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27922535/association-between-short-term-exposure-to-ultrafine-particles-and-mortality-in-eight-european-urban-areas
#4
Massimo Stafoggia, Alexandra Schneider, Josef Cyrys, Evangelia Samoli, Zorana Jovanovic Andersen, Getahun Bero Bedada, Tom Bellander, Giorgio Cattani, Konstantinos Eleftheriadis, Annunziata Faustini, Barbara Hoffmann, Bénédicte Jacquemin, Klea Katsouyanni, Andreas Massling, Juha Pekkanen, Noemi Perez, Annette Peters, Ulrich Quass, Tarja Yli-Tuomi, Francesco Forastiere
BACKGROUND: Epidemiologic evidence on the association between short-term exposure to ultrafine particles and mortality is weak, due to the lack of routine measurements of these particles and standardized multi-center studies. We investigated the relationship between ultrafine particles and particulate matter (PM) and daily mortality in eight European urban areas. METHODS: We collected daily data on non-accidental and cardio-respiratory mortality, particle number concentrations (as proxy for ultrafine particle number concentration), fine and coarse PM, gases and meteorologic parameters in eight urban areas of Finland, Sweden, Denmark, Germany, Italy, Spain, and Greece, between 1999 and 2013...
November 29, 2016: Epidemiology
https://www.readbyqxmd.com/read/27891191/birth-weight-for-gestational-age-is-associated-with-dna-methylation-at-birth-and-in-childhood
#5
Golareh Agha, Hanine Hajj, Sheryl L Rifas-Shiman, Allan C Just, Marie-France Hivert, Heather H Burris, Xihong Lin, Augusto A Litonjua, Emily Oken, Dawn L DeMeo, Matthew W Gillman, Andrea A Baccarelli
BACKGROUND: Both higher and lower fetal growth are associated with cardio-metabolic health later in life, suggesting that prenatal developmental programming determines long-term cardiovascular disease risk. Epigenetic mechanisms, which orchestrate fetal growth and development, may offer insight on the early programming of health and disease. We investigated whether birth weight-for-gestational is associated with DNA methylation at birth and mid-childhood, measured via the Infinium 450K array...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27882292/muscular-strength-and-endurance-and-cardio-metabolic-health-in-disadvantaged-hispanic-children-from-the-u-s
#6
Ryan D Burns, Timothy A Brusseau
The predictive relationship between muscular strength and endurance and cardio-metabolic health, independent from aerobic fitness, is not clear in disadvantaged Hispanic children. The purpose of this study was to examine the predictive relationship between muscular strength and endurance and clustered cardio-metabolic risk, controlling for aerobic fitness, in Hispanic children from low-income schools. Participants were 320 Hispanic children (Mean age = 10.1 ± 1.1 years; 164 girls, 156 boys) recruited during the 2014-2015 and 2015-2016 academic years from five low-income schools from the state of Utah in the U...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27882040/a-new-model-of-master-of-philosophy-in-physiological-sciences
#7
H R Ahmad, F M Arain, N A Khan
The objectives of Master of Philosophy (MPhil) in Physiological Sciences are: 1) to describe the new ways in which anatomy, biochemistry and physiology on one hand, and microbiology, pathology and pharmacology on other hand meet their functional requirements through multidisciplinary integrated concepts; 2) to elucidate relationships between cell biology, molecular biology and molecular genetics by connecting dots of how cell functions are driven by molecules and being controlled by genes. This forms the basis of cell, molecular and genetics [CMG] module upon which 7 multidisciplinary modules of Physiological Sciences follow; 3) these 24 credit hours provide the physiological basis for PhD studies as well as faculty development to enhance learning abilities of medical student; 4) the modules constitute Cardio- Respiratory Physiological Sciences, GI and Renal Physiological Sciences, Neurosciences, Endo-Reproductive Physiological Sciences...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27867201/does-body-mass-index-modify-the-association-between-physical-activity-and-screen-time-with-cardio-metabolic-risk-factors-in-adolescents-findings-from-a-countrywide-survey
#8
F V Cureau, U Ekelund, K V Bloch, B D Schaan
BACKGROUND: Moderate and vigorous physical activity (MVPA) and screen time (ST) have been associated with cardio-metabolic health in youth. However, previous studies are conflicting whether these associations are independent of each other and it is unknown if they are modified by adiposity. We aimed to examine the independent and joint associations between MVPA and ST with cardio-metabolic risk across BMI categories. METHODS: A total of 36 956 Brazilian adolescents (12-17 years) from Study of Cardiovascular Risks in Adolescents were included...
November 21, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27866565/regional-differences-in-the-prevalence-of-cardiovascular-disease
#9
Christina Dornquast, Lars E Kroll, Hannelore K Neuhauser, Stefan N Willich, Thomas Reinhold, Markus A Busch
BACKGROUND: Cardiovascular disease continues to be the single most common cause of death and to account for the largest single portion of treatment costs in Germany. Reliable data on regional differences in the frequency of cardio - vascular disease are important for the planning of targeted care structures and preventive measures. METHODS: Pooled data from the German Health Update (GEDA), a nationwide telephone health survey conducted in 2009, 2010 and 2012 (n = 62 214) were used to estimate the lifetime prevalence of major cardiovascular disease (self-reported medical diagnosis of myocardial infarction, other coronary heart disease, stroke, or congestive heart failure) in each of the German federal states...
October 21, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27863480/effects-of-lifestyle-intervention-using-patient-centered-cognitive-behavioral-therapy-among-patients-with-cardio-metabolic-syndrome-a-randomized-controlled-trial
#10
Ying Zhang, Songli Mei, Rui Yang, Ling Chen, Hang Gao, Li Li
BACKGROUND: Cardio-metabolic syndrome (CMS) is a highly prevalent condition. There is an urgent need to identify effective and integrated multi-disciplinary approaches that can reduce risk factors for CMS. METHODS: Sixty-two patients with a history of CMS were randomized 1:1 into two groups: a standard information -only group (control), or a self-regulated lifestyle waist circumference (patient-centered cognitive behavioral therapy) intervention group. A pretest and posttest, controlled, experimental design was used...
November 18, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27855382/childhood-health-consequences-of-maternal-obesity-during-pregnancy-a-narrative-review
#11
Romy Gaillard, Susana Santos, Liesbeth Duijts, Janine F Felix
BACKGROUND: Obesity is a major public health problem among women of reproductive age. In a narrative review, we examined the influence of maternal obesity during pregnancy on fetal outcomes and childhood adiposity, cardio-metabolic, respiratory and cognitive-related health outcomes. We discuss results from recent studies, the causality and potential underlying mechanisms of observed associations and challenges for future epidemiological studies. SUMMARY: Evidence from observational studies strongly suggests that maternal pre-pregnancy obesity and excessive gestational weight gain are associated with increased risks of fetal pregnancy complications and adverse childhood cardio-metabolic, respiratory and cognitive-related health outcomes...
November 18, 2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27832203/angiotensin-converting-enzyme-inhibitors-angiotensin-receptor-blockers-and-calcium-channel-blockers-are-associated-with-prolonged-vascular-access-patency-in-uremic-patients-undergoing-hemodialysis
#12
Fu-An Chen, Chih-Chiang Chien, Yu-Wei Chen, Yu-Te Wu, Chih-Ching Lin
BACKGROUND: Vascular access failure is a huge burden for patients undergoing hemodialysis. Many efforts have been made to maintain vascular access patency, including pharmacotherapy. Angiotensin converting enzyme inhibitor (ACE-I), angiotensin receptor blocker (ARB), and calcium channel blocker (CCB) are known for their antihypertensive and cardio-protective effects, however, their effects on long-term vascular access patency are still inconclusive. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: We retrospectively enrolled patients commencing maintenance hemodialysis between January 1, 2000, and December 31, 2006 by using National Health Insurance Research Database in Taiwan...
2016: PloS One
https://www.readbyqxmd.com/read/27829526/sex-specific-incidence-rates-and-risk-factors-of-premature-cardiovascular-disease-a-long-term-follow-up-of-the-tehran-lipid-and-glucose-study
#13
Ali Eslami, Amirhossein Mozaffary, Arash Derakhshan, Fereidoun Azizi, Davood Khalili, Farzad Hadaegh
OBJECTIVES: To investigate the risk factors for premature cardiovascular disease (CVD) and to quantify their population attributable fractions (PAFs) among an Iranian population during a median follow-up of 12years. METHODS: A total of 2235 men and 3703 women, aged ≥30years, free of CVD at baseline were entered into the study. Premature CVD was defined as having a history of CVD events before the age of 55 and 65 for men and women, respectively. Multivariate Cox proportional hazard regression models were used to determine the risk factors associated with premature CVD events...
October 17, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27818933/inhibition-of-citrate-cotransporter-slc13a5-mindy-by-rnai-improves-hepatic-insulin-sensitivity-and-prevents-diet-induced-non-alcoholic-fatty-liver-disease-in-mice
#14
Sebastian Brachs, Angelika F Winkel, Hui Tang, Andreas L Birkenfeld, Bodo Brunner, Kerstin Jahn-Hofmann, Daniel Margerie, Hartmut Ruetten, Dieter Schmoll, Joachim Spranger
OBJECTIVE: Non-alcoholic fatty liver disease is a world-wide health concern and risk factor for cardio-metabolic diseases. Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate cotransporter solute carrier family 13 member 5 (SLC13A5, mammalian homolog of INDY: mINDY). In Drosophila melanogaster and Caenorhabditis elegans INDY reduction decreased whole-body lipid accumulation. Genetic deletion of Slc13a5 in mice protected from diet-induced adiposity and insulin resistance...
November 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27808003/effects-of-a-fifty-six-month-electrical-stimulation-cycling-program-after-tetraplegia-case-report
#15
David R Dolbow, Ashraf S Gorgey, Refka K Khalil, David R Gater
BACKGROUND: Functional electrical stimulation cycling is a common clinical treatment for individuals with spinal cord injury and other paralytic conditions, however, the long term effects of home-based functional electrical stimulation cycling remains unreported. OBJECTIVE: To determine the effectiveness of a long-term home-based functional electrical stimulation lower extremities cycling (FES-LEC) program on body composition. PARTICIPANT: An adult male 52...
November 3, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27798770/impact-of-a-proprietary-standardized-olive-fruit-extract-sofe-on-cardio-ankle-vascular-index-visual-analog-scale-and-c-reactive-protein-assessments-in-subjects-with-arterial-stiffness-risk
#16
Pilar Pais, Agustin Villar, Santiago Rull
INTRODUCTION: The chemical components of olive fruit provide a wide range of cardiovascular benefits. Arterial stiffness is an important cardiovascular risk factor and can be assessed using the Cardio-Ankle Vascular Index (CAVI). OBJECTIVE: The objective of this study was to assess the impact of a proprietary standardized olive fruit extract (SOFE) in subjects at risk for arterial stiffness. METHODS: Twelve of 36 subjects were assigned to each of the following groups for this 11-day, double-blind, placebo-controlled study: Group 1: 250 mg SOFE-50 mg active ingredient, hydroxytyrosol (dosage achieved with two capsules per day); Group 2: 500 mg SOFE-100 mg active ingredient, hydroxytyrosol (dosage achieved with two capsules per day); and Group 3: placebo...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27795553/intra-gastric-balloon-as-an-adjunct-to-lifestyle-support-in-severely-obese-adolescents-impact-on-weight-physical-activity-cardio-respiratory-fitness-and-psychosocial-wellbeing
#17
L J Reece, N P Wright, P Sachdev, M Thomson, J K Wales, R J Copeland
BACKGROUND: Severe adolescent obesity (BMI>99.6th centile) is a significant public health challenge. Current non-invasive treatments, including community-based lifestyle interventions, are often of limited effectiveness in this population, with NICE guidelines suggesting the use of bariatric surgery as the last line of treatment (NICE, 2013). Health professionals are understandably reluctant to commission bariatric surgery and as an alternative, the use of an intra-gastric balloon as an adjunct to a lifestyle programme might offer a reversible, potentially safer and less invasive option...
October 31, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27793125/living-well-after-breast-cancer-randomized-controlled-trial-protocol-evaluating-a-telephone-delivered-weight-loss-intervention-versus-usual-care-in-women-following-treatment-for-breast-cancer
#18
Marina M Reeves, Caroline O Terranova, Jane M Erickson, Jennifer R Job, Denise S K Brookes, Nicole McCarthy, Ingrid J Hickman, Sheleigh P Lawler, Brianna S Fjeldsoe, Genevieve N Healy, Elisabeth A H Winkler, Monika Janda, J Lennert Veerman, Robert S Ware, Johannes B Prins, Theo Vos, Wendy Demark-Wahnefried, Elizabeth G Eakin
BACKGROUND: Obesity, physical inactivity and poor diet quality have been associated with increased risk of breast cancer-specific and all-cause mortality as well as treatment-related side-effects in breast cancer survivors. Weight loss intervention trials in breast cancer survivors have shown that weight loss is safe and achievable; however, few studies have examined the benefits of such interventions on a broad range of outcomes and few have examined factors important to translation (e...
October 28, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27777756/first-hospital-outbreak-of-the-globally-emerging-candida-auris-in-a-european-hospital
#19
Silke Schelenz, Ferry Hagen, Johanna L Rhodes, Alireza Abdolrasouli, Anuradha Chowdhary, Anne Hall, Lisa Ryan, Joanne Shackleton, Richard Trimlett, Jacques F Meis, Darius Armstrong-James, Matthew C Fisher
BACKGROUND: Candida auris is a globally emerging multidrug resistant fungal pathogen causing nosocomial transmission. We report an ongoing outbreak of C. auris in a London cardio-thoracic center between April 2015 and July 2016. This is the first report of C. auris in Europe and the largest outbreak so far. We describe the identification, investigation and implementation of control measures. METHODS: Data on C. auris case demographics, environmental screening, implementation of infection prevention/control measures, and antifungal susceptibility of patient isolates were prospectively recorded then analysed retrospectively...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27775595/the-molecular-and-cellular-effect-of-homocysteine-metabolism-imbalance-on-human-health
#20
Henrieta Škovierová, Eva Vidomanová, Silvia Mahmood, Janka Sopková, Anna Drgová, Tatiana Červeňová, Erika Halašová, Ján Lehotský
Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid derived in methionine metabolism. The increased level of Hcy in plasma, hyperhomocysteinemia, is considered to be an independent risk factor for cardio and cerebrovascular diseases. However, it is still not clear if Hcy is a marker or a causative agent of diseases. More and more research data suggest that Hcy is an important indicator for overall health status. This review represents the current understanding of molecular mechanism of Hcy metabolism and its link to hyperhomocysteinemia-related pathologies in humans...
October 20, 2016: International Journal of Molecular Sciences
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