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https://www.readbyqxmd.com/read/28528430/risk-classification-of-highly-sensitive-troponin-i-predict-presence-of-vulnerable-plaque-assessed-by-dual-source-coronary-computed-tomography-angiography
#1
Ting Liu, Guan Wang, Peiling Li, Xu Dai
Patients presenting to the emergency department with acute chest pain, negative conventional troponin and electrocardiogram require serial testing to rule out acute coronary syndrome (ACS). We studied the association of highly sensitive troponin (hsTn) I with vulnerable plaque features as detected by coronary dual source computed tomography angiography (DSCTA) and determined whether hsTn I at the time of presentation combined with early DSCTA could improve classification of patients as high-risk or low risk for ACS...
May 20, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28528190/association-between-the-time-to-surgery-and-survival-among-patients-with-colon-cancer-a-population-based-study
#2
J A Flemming, S Nanji, X Wei, C Webber, P Groome, C M Booth
Factors associated with time-to-surgery (TTS) and survival in colon cancer has not been well studied. Cancer Care Ontario recommends surgery within 42 days of diagnosis and that 90% of patients meet this benchmark. We describe factors associated with TTS and survival in routine clinical practice. METHODS: Retrospective population-based cohort study of patients receiving elective colonic resection after diagnosis of colon cancer in Ontario, Canada from 2002 to 2008 followed until 2012...
May 6, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28527867/association-of-neck-circumference-and-pulmonary-function-in-children
#3
Onur Akın, Mutluay Arslan, Cem Haymana, Erdem Karabulut, Bulent Hacihamdioglu, Suleyman Tolga Yavuz
BACKGROUND: Childhood obesity leads to many complications including impaired respiratory function. There are various anthropometric parameters related to obesity. OBJECTIVE: To investigate the correlation between anthropometric indices and pulmonary function test results in children without asthma. METHODS: Children without any respiratory disorders were enrolled in this study. Anthropometric measurements, such as height, weight, neck circumference (NC), and waist circumference, were obtained from the enrollees and body mass index was calculated...
May 17, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28527750/estimating-serum-concentrations-of-dioxin-like-compounds-in-the-u-s-population-effective-2005-2006-and-2007-2008-a-multiple-imputation-and-trending-approach-incorporating-nhanes-pooled-sample-data
#4
Anne Bichteler, Daniele S Wikoff, Francis Loko, Mark A Harris
Dioxin-like compounds (DLCs) are monitored in the U.S. population using data collected with the National Health and Nutrition Examination Survey (NHANES). Until recently, participants' serum samples have been analyzed individually, and summary statistics defining reference ranges by age, gender, and race/ethnicity have served as the background by which other biomonitoring data can be evaluated. In the most recent NHANES DLC data, 2005-2006 and 2007-2008, participants' sera have been physically pooled prior to laboratory analysis, introducing major challenges to their utility as a reference population: variability among individuals and relations with covariates are lost, and individual design effects cannot be applied...
May 18, 2017: Environment International
https://www.readbyqxmd.com/read/28527220/quantitative-erythrocyte-omega-3-epa-plus-dha-levels-are-related-to-higher-regional-cerebral-blood-flow-on-brain-spect
#5
Daniel G Amen, William S Harris, Parris M Kidd, Somayeh Meysami, Cyrus A Raji
BACKGROUND: The interrelationships between omega-3 fatty acids status, brain perfusion, and cognition are not well understood. OBJECTIVE: To evaluate if SPECT brain imaging of cerebral perfusion and cognition varies as a function of omega-3 fatty acid levels. METHODS: A random sample of 166 study participants was drawn from a psychiatric referral clinical for which erythrocyte quantification of omega-3 eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) (the Omega-3 Index) was available...
May 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28527212/apolipoprotein-e4-gender-body-mass-index-inflammation-insulin-resistance-and-air-pollution-interactions-recipe-for-alzheimer-s-disease-development-in-mexico-city-young-females
#6
Lilian Calderón-Garcidueñas, Suzanne M de la Monte
Given the epidemiological trends of increasing Alzheimer's disease (AD) and growing evidence that exposure and lifestyle factors contribute to AD risk and pathogenesis, attention should be paid to variables such as air pollution, in order to reduce rates of cognitive decline and dementia. Exposure to fine particulate matter (PM2.5) and ozone (O3) above the US EPA standards is associated with AD risk. Mexico City children experienced pre- and postnatal high exposures to PM2.5, O3, combustion-derived iron-rich nanoparticles, metals, polycyclic aromatic hydrocarbons, and endotoxins...
May 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28527121/brief-biofeedback-intervention-on-anxious-freshman-university-students
#7
Paulo Chaló, Anabela Pereira, Patrícia Batista, Luis Sancho
The increasing number of mental health disorders on university students represents a growing problem with negative impact on this population. Stress and anxiety issues are two of most predominant problems in this population and most campus health services have limited resources to face them. Research has provided evidence about biofeedback effectiveness. This study aims to verify the impact of a short duration biofeedback programme on freshmen university students with high levels of anxiety. A sample of 50 first-year students, with scores above percentile of 75 on STAI Y-2 were randomly selected and divided into two groups...
May 19, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/28526941/urinary-cadmium-and-cotinine-levels-and-hair-mercury-levels-in-czech-children-and-their-mothers-within-the-framework-of-the-cophes-democophes-projects
#8
Kateřina Forysová, Anna Pinkr-Grafnetterová, Marek Malý, Andrea Krsková, Jaroslav Mráz, Lucie Kašparová, Mája Čejchanová, Lenka Sochorová, Sylva Rödlová, Milena Černá
The COPHES/DEMOCOPHES twin project was performed in 2011-2012 in 17 European countries to harmonize all steps of the human biomonitoring survey. Urinary cadmium, cotinine, phthalate metabolites, and hair mercury were measured in children (N = 120, 6-11 years) and their mothers of reproductive age, living in urban or rural areas. Cadmium in mothers' and children's urine was detected at a geometric mean (GM) concentration 0.227 and 0.109 μg/L, respectively; 95th percentile (P95) was 0.655 and 0.280 μg/L in mothers and children, respectively...
May 19, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28526698/improving-response-in-genomic-selection-with-a-population-based-selection-strategy-optimal-population-value-selection
#9
Matthew Goiffon, Aaron Kusmec, Lizhi Wang, Guiping Hu, Patrick Schnable
Genomic selection (GS) identifies individuals for inclusion in breeding programs based on the sum of their estimated marker effects or genomic estimated breeding values (GEBVs). Due to significant correlation between GEBVs and true breeding values, this has resulted in enhanced rates of genetic gain as compared to traditional methods of selection. Three extensions to GS, weighted genomic selection (WGS), optimal haploid value (OHV) selection, and genotype building (GB) selection have been proposed to improve long-term response and to facilitate the efficient development of doubled haploids...
May 19, 2017: Genetics
https://www.readbyqxmd.com/read/28526433/risk-of-low-birth-weight-and-micronutrient-deficiencies-in-neonates-from-mothers-after-gastric-bypass-a-case-control-study
#10
Geraldine Gascoin, Maxime Gerard, Agnès Sallé, Guillaume Becouarn, Stephanie Rouleau, Loïc Sentilhes, Régis Coutant
BACKGROUND: An increased risk of small-for-gestational-age infants after maternal bariatric surgery has been shown. The risk of micronutrients deficiencies in these neonates is unclear. OBJECTIVE: To screen for micronutrients deficiencies in newborns of mothers with gastric bypass. SETTINGS: University hospital in Angers, France. METHODS: This study compared the clinical and cord blood biological characteristics of 56 newborns of mothers with prior Roux-en-Y gastric bypass (RYGB) and 56 newborns of nonobese healthy mothers after normal pregnancy (controls), followed between January 3, 2008 and October 31, 2012...
March 27, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28526275/increasing-total-serum-ige-allergic-bronchopulmonary-aspergillosis-and-lung-function-in-cystic-fibrosis
#11
Florian Gothe, Matthias Kappler, Matthias Griese
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity disorder contributing to lung disease in cystic fibrosis (CF) and challenging to diagnose. OBJECTIVE: This study analyzed the predictive value of increasing total IgE (t-IgE) levels in a CF cohort alongside with clinical and serologic data. METHODS: A total of 387 children and young adults were followed from 2000 to 2006 and retrospectively classified into 6 groups...
May 16, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28526242/factors-predicting-complications-after-sacral-neuromodulation-in-children
#12
Molly E Fuchs, Peter L Lu, Stephanie J Vyrostek, Steven Teich, Seth A Alpert
OBJECTIVES: To identify if any pre-operative variable are associated with post-operative complications after pediatric sacral neuromodulation (SNM). METHODS: A review of all patients undergoing SNM with an implantable pulse generator at our institution was performed. Post-operative infection, lead migration, lead breakage and need for reoperation were recorded in a prospective database. We collected demographic information and indication for the procedure. We defined indication for procedure as either primarily bowel, or primarily bladder symptoms...
May 16, 2017: Urology
https://www.readbyqxmd.com/read/28525383/histogram-analysis-of-diffusion-kurtosis-imaging-of-nasopharyngeal-carcinoma-correlation-between-quantitative-parameters-and-clinical-stage
#13
Xiao-Quan Xu, Gao Ma, Yan-Jun Wang, Hao Hu, Guo-Yi Su, Hai-Bin Shi, Fei-Yun Wu
PURPOSE: To evaluate the correlation between histogram parameters derived from diffusion-kurtosis (DK) imaging and the clinical stage of nasopharyngeal carcinoma (NPC). RESULTS: High T-stage (T3/4) NPC showed significantly higher Kapp-mean (P = 0.018), Kapp-median (P = 0.029) and Kapp-90th (P = 0.003) than low T-stage (T1/2) NPC. High N-stage NPC (N2/3) showed significantly lower Dapp-mean (P = 0.002), Dapp-median (P = 0.002) and Dapp-10th (P < 0.001) than low N-stage NPC (N0/1)...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28523354/investigation-of-reference-levels-and-radiation-dose-associated-with-abdominal-evar-endovascular-aneurysm-repair-procedures-across-several-european-centres
#14
E Tuthill, L O'Hora, M O'Donohoe, S Panci, P Gilligan, D Campion, R Trenti, E Fox, D Catania, L Rainford
OBJECTIVES: Endovascular aneurysm repair (EVAR) is considered the treatment of choice for abdominal aortic aneurysms with suitable anatomy. In order to improve radiation safety, European Directive (2013/59) requires member states to implement diagnostic reference levels (DRLs) in radio-diagnostic and interventional procedures. This study aimed to determine local DRLs for EVAR across five European centres and identify an interim European DRL, which currently remains unestablished. METHODS: Retrospective data was collected for 180 standard EVARs performed between January 2014 and July 2015 from five specialist centres in Ireland (n=2) and Italy (n=3)...
May 18, 2017: European Radiology
https://www.readbyqxmd.com/read/28522771/how-to-determine-an-impaired-health-status-in-copd-results-from-a-population-based-study
#15
D E Smid, M A Spruit, D J H Deeg, M Huisman, J Poppelaars, E F M Wouters, F M E Franssen
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with a significantly impaired health status and lost work productivity across all degrees of airflow limitation. The current study investigated whether an impaired health status is better represented by the recommended COPD Assessment Test (CAT) cut-point of 10 points, or the 95th percentile of the CAT score in a non-COPD population. Additionally, the impact of COPD on health status in a Dutch population, after stratification for work status, was measured...
May 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/28522444/harmonization-of-serum-thyroid-stimulating-hormone-measurements-paves-the-way-for-the-adoption-of-a-more-uniform-reference-interval
#16
Linda M Thienpont, Katleen Van Uytfanghe, Linde A C De Grande, Dries Reynders, Barnali Das, James D Faix, Finlay MacKenzie, Brigitte Decallonne, Akira Hishinuma, Bruno Lapauw, Paul Taelman, Paul Van Crombrugge, Annick Van den Bruel, Brigitte Velkeniers, Paul Williams
BACKGROUND: The IFCC Committee for Standardization of Thyroid Function Tests developed a global harmonization approach for thyroid-stimulating hormone measurements. It is based on a multiassay method comparison study with clinical serum samples and target setting with a robust factor analysis method. Here we describe the Phase IV method comparison and reference interval (RI) studies conducted with the objective to recalibrate the participating assays and demonstrate the proof-of-concept...
May 18, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28520952/defining-optimal-health-range-for-thyroid-function-based-on-the-risk-of-cardiovascular-disease
#17
L Chaker, T I M Korevaar, D Rizopoulos, T-H Collet, H Völzke, A Hofman, N Rodondi, A R Cappola, R P Peeters, O H Franco
Context: Reference ranges of thyroid stimulating hormone (TSH) and free thyroxine (FT4) are defined by their distribution in apparently healthy populations, (2.5th and 97.5th percentiles) irrespective of disease risk and used as cut-offs for defining and clinically managing thyroid dysfunction. Objective: To provide a proof of concept in defining thyroid function optimal health ranges based on cardiovascular disease (CVD) mortality risk. Design and Participants: 9,233 participants from the Rotterdam Study (mean age 65...
May 17, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28520645/oxidative-stress-and-breast-cancer-risk-in-premenopausal-women
#18
Hazel B Nichols, Chelsea Anderson, Alexandra J White, Ginger L Milne, Dale P Sandler
BACKGROUND: Detrimental effects of oxidative stress are widely recognized, but induction of apoptosis and senescence may also have benefits for cancer prevention. Recent studies suggest oxidative stress may be associated with lower breast cancer risk before menopause. METHODS: We conducted a nested case-control study (N=457 cases, 910 controls) within the NIEHS Sister Study cohort of 50,884 women. Premenopausal women ages 35-54 were eligible for selection. We matched controls 2:1 to cases on age and enrollment year and were breast cancer-free at the time of the corresponding case's diagnosis...
May 17, 2017: Epidemiology
https://www.readbyqxmd.com/read/28515410/differentiating-between-central-nervous-system-lymphoma-and-high-grade-glioma-using-dynamic-susceptibility-contrast-and-dynamic-contrast-enhanced-mr-imaging-with-histogram-analysis
#19
Kazuhiro Murayama, Yuya Nishiyama, Yuichi Hirose, Masato Abe, Shigeharu Ohyu, Ayako Ninomiya, Takashi Fukuba, Kazuhiro Katada, Hiroshi Toyama
PURPOSE: We evaluated the diagnostic performance of histogram analysis of data from a combination of dynamic susceptibility contrast (DSC)-magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE)-MRI for quantitative differentiation between central nervous system lymphoma (CNSL) and high-grade glioma (HGG), with the aim of identifying useful perfusion parameters as objective radiological markers for differentiating between them. METHODS: Eight lesions with CNSLs and 15 with HGGs who underwent MRI examination, including DCE and DSC-MRI, were enrolled in our retrospective study...
May 18, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28515099/temporal-biomarker-profiling-reveals-longitudinal-changes-in-risk-of-death-or-myocardial-infarction-in-non-st-segment-elevation-acute-coronary-syndrome
#20
Mark Chan, Megan L Neely, Matthew T Roe, Shaun G Goodman, David Erlinge, Jan H Cornel, Kenneth J Winters, Joseph A Jakubowski, Chunmei Zhou, Keith A A Fox, Paul W Armstrong, Harvey D White, Dorairaj Prabhakaran, E Magnus Ohman, Kurt Huber
BACKGROUND: There are conflicting data on whether changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) concentrations between time points (delta NT-proBNP and hs-CRP) are associated with a change in prognosis. METHODS: We measured NT-proBNP and hs-CRP at 3 time points in 1665 patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Cox proportional hazards was applied to the delta between temporal measurements to determine the continuous association with cardiovascular events...
May 17, 2017: Clinical Chemistry
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