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https://www.readbyqxmd.com/read/27933274/screening-and-identification-of-an-h-2k-b-restricted-ctl-epitope-within-the-glycoprotein-of-hantaan-virus
#1
Rui-Xue Ma, Lin-Feng Cheng, Qi-Kang Ying, Rong-Rong Liu, Tie-Jun Ma, Xiao-Xiao Zhang, Zi-Yu Liu, Liang Zhang, Wei Ye, Fang-Lin Zhang, Zhi-Kai Xu, Fang Wang, Xing-An Wu
The cytotoxic T lymphocyte (CTL) response plays a key role in controlling viral infection, but only a few epitopes within the HTNV glycoprotein (GP) that are recognized by CTLs have been reported. In this study, we identified one murine HTNV GP-derived H2-K(b)-restricted CTL epitope in C57BL/6 mice, which could be used to design preclinical studies of vaccines for HTNV infection. First, 15 8-mer peptides were selected from the HTNV GP amino acid sequence based on a percentile rank of <=1% by IEDB which is the most comprehensive collection of epitope prediction and analysis tool...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27933220/a-novel-method-for-quantitative-serial-autofluorescence-analysis-in-retinitis-pigmentosa-using-image-characteristics
#2
Jasleen K Jolly, Siegfried K Wagner, Jonathan Moules, Florian Gekeler, Andrew R Webster, Susan M Downes, Robert E MacLaren
PURPOSE: Identifying potential biomarkers for disease progression in retinitis pigmentosa (RP) is highly relevant now that gene therapy and other treatments are in clinical trial. Here we report a novel technique for analysis of short-wavelength autofluorescence (AF) imaging to quantify defined regions of AF in RP patients. METHODS: Fifty-five-degree AF images were acquired from 12 participants with RP over a 12-month period. Of these, five were identified as having a hyperfluorescent annulus...
December 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27932666/interval-estimation-for-a-proportion-using-a-double-sampling-scheme-with-two-fallible-classifiers
#3
Shi-Fang Qiu, Heng Lian, G Y Zou, Xiao-Song Zeng
Double-sampling schemes using one classifier assessing the whole sample and another classifier assessing a subset of the sample have been introduced for reducing classification errors when an infallible or gold standard classifier is unavailable or impractical. Inference procedures have previously been proposed for situations where an infallible classifier is available for validating a subset of the sample that has already been classified by a fallible classifier. Here, we consider the case where both classifiers are fallible, proposing and evaluating several confidence interval procedures for a proportion under two models, distinguished by the assumption regarding ascertainment of two classifiers...
December 8, 2016: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/27932505/diagnostic-accuracy-of-t1-weighted-dynamic-contrast-enhanced-mri-and-dwi-adc-for-differentiation-of-glioblastoma-and-primary-cns-lymphoma
#4
X Lin, M Lee, O Buck, K M Woo, Z Zhang, V Hatzoglou, A Omuro, J Arevalo-Perez, A A Thomas, J Huse, K Peck, A I Holodny, R J Young
BACKGROUND AND PURPOSE: Glioblastoma and primary CNS lymphoma dictate different neurosurgical strategies; it is critical to distinguish them preoperatively. However, current imaging modalities do not effectively differentiate them. We aimed to examine the use of DWI and T1-weighted dynamic contrast-enhanced-MR imaging as potential discriminative tools. MATERIALS AND METHODS: We retrospectively reviewed 18 patients with primary CNS lymphoma and 36 matched patients with glioblastoma with pretreatment DWI and dynamic contrast-enhanced-MR imaging...
December 8, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27932053/green-and-lean-is-neighborhood-park-and-playground-availability-associated-with-youth-obesity-variations-by-gender-socioeconomic-status-and-race-ethnicity
#5
S Morgan Hughey, Andrew T Kaczynski, Stephanie Child, Justin B Moore, Dwayne Porter, James Hibbert
Parks and park features are important for promoting physical activity and healthy weight, especially for low-income and racial/ethnic minority youth who have disproportionately high obesity rates. This study 1) examined associations between neighborhood park and playground availability and youth obesity, and 2) assessed whether these associations were moderated by youth race/ethnicity and socioeconomic status (SES). In 2013, objectively measured height and weight were collected for all 3(rd)-5(th) grade youth (n=13,469) in a southeastern US county to determine body mass index (BMI) percentiles...
December 5, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27932021/metabolic-syndrome-in-adolescents-definition-based-on-regression-of-idf-adult-cut-off-points
#6
K Benmohammed, P Valensi, B Balkau, A Lezzar
OBJECTIVES: The objective of this study was to derive a sex- and age-specific definition of the metabolic syndrome (MetS) and its abnormalities for adolescents. STUDY DESIGN: This is a cross-sectional study. METHODS: A total of 1100 adolescent students, aged 12-18 y, were randomly selected from schools and classrooms in the city of Constantine, Algeria; all had anthropometric measurements taken, and 989 had blood tests. Gender-specific growth curves for components of the MetS were derived, using the LMS (lambda-mu-sigma) method, and the percentiles corresponding to the thresholds of the MetS components proposed for adults by the International Diabetes Federation (IDF) were identified...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931584/evaluation-of-pregnancy-outcomes-after-liver-transplantation
#7
M Akarsu, T Unek, A Avcu, M Ozbilgin, T Egeli, I Astarcioglu
Liver transplantation is increasing worldwide. Pregnancy after liver transplantation is considered to be well tolerated with favorable neonatal outcomes in cases of stable and sufficient graft function. In this study, our aim was to determine pregnancy and neonatal outcomes of patients after liver transplantation. Data for patients who had been followed-up by the liver transplantation clinic at the Dokuz Eylül University Medical Faculty Hospital, Turkey, between 2002 and 2016, and who had pregnancy after the transplantation were evaluated retrospectively...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931558/time-to-shift-from-contemporary-to-high-sensitivity-cardiac-troponin-in-diagnosis-of-acute-coronary-syndromes
#8
REVIEW
Jamshed J Dalal, C K Ponde, Brian Pinto, C N Srinivas, Joy Thomas, Sunil Kumar Modi, Sanjay Mehta, Suvin Shetty, Manimarane, Bhupen Desai
Early rule-in and rule-out of non-ST-segment elevation myocardial infarction (NSTEMI) is a challenge. In patients with inconclusive findings on ECG, cardiac biomarkers play a crucial role in the diagnosis. The introduction of the new high-sensitive cardiac troponin test (hs-TnI assay) has changed the landscape of NSTEMI diagnosis. The new hs-TnI assay can detect troponin values at a lower level compared with a contemporary cardiac troponin (cTn) assay. The hs-cTnI assay has a coefficient of variation of ≤10%, well below the 99th percentile value...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27931554/a-study-to-derive-distribution-of-carotid-intima-media-thickness-and-to-determine-its-correlation-with-cardiovascular-risk-factors-in-asymptomatic-nationwide-indian-population-score-india
#9
Ravi R Kasliwal, Manish Bansal, Nagaraj Desai, Bhavesh Kotak, Ammar Raza, Hardik Vasnawala, Amit Kumar
BACKGROUND: There is presently no data to describe normal distribution of carotid intima-media thickness (CIMT), an established measure of subclinical atherosclerosis, in Indian subjects. METHODS: In this multi-centric study, 1229 subjects with age ≥30 years and no previous cardiovascular disease (CVD) underwent CVD risk factor assessment and CIMT measurement. Mean far wall common carotid artery IMT was measured on both sides and averaged. RESULTS: Mean age of the subjects was 48...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27931260/prediction-of-breast-cancer-risk-based-on-common-genetic-variants-in-women-of-east-asian-ancestry
#10
Wanqing Wen, Xiao-Ou Shu, Xingyi Guo, Qiuyin Cai, Jirong Long, Manjeet K Bolla, Kyriaki Michailidou, Joe Dennis, Qin Wang, Yu-Tang Gao, Ying Zheng, Alison M Dunning, Montserrat García-Closas, Paul Brennan, Shou-Tung Chen, Ji-Yeob Choi, Mikael Hartman, Hidemi Ito, Artitaya Lophatananon, Keitaro Matsuo, Hui Miao, Kenneth Muir, Suleeporn Sangrajrang, Chen-Yang Shen, Soo H Teo, Chiu-Chen Tseng, Anna H Wu, Cheng Har Yip, Jacques Simard, Paul D P Pharoah, Per Hall, Daehee Kang, Yongbing Xiang, Douglas F Easton, Wei Zheng
BACKGROUND: Approximately 100 common breast cancer susceptibility alleles have been identified in genome-wide association studies (GWAS). The utility of these variants in breast cancer risk prediction models has not been evaluated adequately in women of Asian ancestry. METHODS: We evaluated 88 breast cancer risk variants that were identified previously by GWAS in 11,760 cases and 11,612 controls of Asian ancestry. SNPs confirmed to be associated with breast cancer risk in Asian women were used to construct a polygenic risk score (PRS)...
December 8, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27931248/postpartum-depression-and-infant-feeding-practices-in-a-low-income-urban-settlement-in-nairobi-kenya
#11
Beatrice A Madeghe, Violet N Kimani, Ann Vander Stoep, Semret Nicodimos, Manasi Kumar
BACKGROUND: Postpartum depression can compromise caregiving activities, including infant feeding practices, resulting in child malnutrition. The purpose of this study was to examine the effects of postpartum depression on infant feeding practices and malnutrition among women in an urban low income settlement in Nairobi-Kenya. We conducted a cross-sectional study based in Kariobangi North Health Centre in Nairobi County. The study sample included 200 mother-infant pairs visiting the Maternal and Child Health clinics for infant immunization at 6-14 weeks postpartum...
December 8, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27931172/biomechanical-response-of-the-infant-head-to-shaking-an-experimental-investigation
#12
Carol Jenny, Gina Bertocci, Tsuguhiro Fukuda, Nagarajan Rangarajan, Tariq Shams
Controversy exists regarding whether violent shaking is harmful to infants in the absence of impact. In this study, our objective was to characterize the biomechanical response of the infant head during shaking through use of an instrumented anthropomorphic test device (commonly referred to as a 'crash test dummy' or infant surrogate) representing a human infant and having improved biofidelity. A series of tests were conducted to simulate violent shaking of an infant surrogate. The Aprica 2.5 infant surrogate represented a 5th percentile Japanese newborn...
December 8, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27930820/a-bayesian-approach-to-age-at-death-estimation-from-osteoarthritis-of-the-shoulder-in-modern-north-americans
#13
Ashley L Brennaman, Kim R Love, Jonathan D Bethard, James T Pokines
Osteoarthritis (OA) is a marker of degeneration within the skeleton, frequently associated with age. This study quantifies the correlation between OA and age-at-death and investigates the utility of shoulder OA as a forensic age indicator using a modern North American sample of 206 individuals. Lipping, surface porosity, osteophyte formation, eburnation, and percentage of joint surface affected were recorded on an ordinal scale and summed to create composite scores that were assigned a specific phase. Spearman's correlation indicated a positive relationship between each composite score and age (right shoulder = 0...
December 8, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27930454/fat-free-mass-index-in-ncaa-division-i-and-ii-collegiate-american-football-players
#14
Eric T Trexler, Abbie E Smith-Ryan, Malia N M Blue, Richard M Schumacher, Jerry L Mayhew, J Bryan Mann, Pat A Ivey, Katie R Hirsch, Meredith G Mock
Fat-free mass index (FFMI) is a height-adjusted assessment of fat-free mass, with previous research suggesting a natural upper limit of 25 kg[BULLET OPERATOR]m in resistance-trained males. The current study evaluated upper limits for FFMI in collegiate American football players (n=235), and evaluated differences between positions, divisions, and age groups. The sample consisted of two NCAA Division I teams (n=78, n=69), and one Division II team (n=88). Body composition was assessed via dual-energy x-ray absorptiometry and used to calculate FFMI; linear regression was used to normalize values to a height of 180 cm...
November 19, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27930394/the-changing-face-of-epidemiology-gender-disparities-in-citations
#15
Enrique F Schisterman, Chandra W Swanson, Ya-Ling Lu, Sunni L Mumford
BACKGROUND: Female biomedical scientists tend to publish fewer articles as last author than their male colleagues and accrue fewer citations per publication. We seek to understand whether epidemiology follows this pattern. METHODS: We gathered aggregate information on the current gender distribution of epidemiology departments (n=29 of 71 surveyed), societies (n=4 of 8), and journal editorial boards (n=6 of 6) using two online surveys and publicly available online information...
December 1, 2016: Epidemiology
https://www.readbyqxmd.com/read/27929528/risk-of-preterm-birth-among-women-using-drugs-during-pregnancy-with-elevated-%C3%AE-fetoprotein
#16
R J Baer, C D Chambers, K K Ryckman, S P Oltman, M E Norton, L L Jelliffe-Pawlowski
OBJECTIVE: Examine the risk of preterm birth (PTB) among women who use drugs during pregnancy and have elevated α-fetoprotein (AFP). STUDY DESIGN: The sample included California singleton live births in 2005 to 2010 contained within a hospital discharge database linked to the Prenatal Screening Program. A selection of mothers who did not use drugs was selected at a ratio of 4:1. Risk of PTB was calculated using adjusted odds ratios and 95% confidence intervals (CIs) for women who did or did not use drugs by their AFP percentile...
December 8, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27929511/evaluation-of-dose-area-product-of-common-radiographic-examinations-towards-establishing-a-preliminary-diagnostic-reference-levels-pdrls-in-southwestern-nigeria
#17
Nnamdi N Jibiri, Christopher J Olowookere
In Nigeria, a large number of radiographic examinations are conducted yearly for various diagnostic purposes. However, most examinations carried out do not have records of doses received by the patients, and the employed exposure parameters used are not documented; therefore, adequate radiation dose management is hin-dered. The aim of the present study was to estimate the dose-area product (DAP) of patients examined in Nigeria, and to propose regional reference dose levels for nine common examinations (chest PA, abdomen AP, pelvis AP, lumbar AP, skull AP, leg AP, knee AP, hand AP, and thigh AP) undertaken in Nigeria...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27927714/contemporary-assessment-of-left-ventricular-diastolic-function-in-older-adults-the-atherosclerosis-risk-in-communities-study
#18
Amil M Shah, Brian Claggett, Dalane Kitzman, Tor Biering-Sørensen, Jan S Jensen, Susan Cheng, Kunihiro Matsushita, Suma H Konety, Aaron R Folsom, Thomas H Mosley, Jacqueline Wright, Gerardo Heiss, Scott D Solomon
BACKGROUND: -While age-associated changes in LV diastolic function are well-recognized, limited data exist characterizing measures of diastolic function in older adults, including both reference ranges reflecting the older adult population and prognostically relevant values for incident HF, as well as their associations with circulating biomarkers of heart failure (HF) risk. METHODS: -Among 5,801 elderly participants in the Atherosclerosis Risk in Communities (ARIC) study (age range 67-90, mean age 76 ± 5, 42% male, 21% black), we determined the continuous association of diastolic measures (TDI e', E/e', and left atrial size) with concomitant NT-proBNP and subsequent HF hospitalization or death...
December 7, 2016: Circulation
https://www.readbyqxmd.com/read/27927632/associations-between-blood-pressure-and-outcomes-among-blacks-in-the-jackson-heart-study
#19
Tiffany C Randolph, Melissa A Greiner, Chidiebube Egwim, Adrian F Hernandez, Kevin L Thomas, Lesley H Curtis, Paul Muntner, Wei Wang, Robert J Mentz, Emily C O'Brien
BACKGROUND: In 2014, new hypertension guidelines liberalized blood pressure goals for persons 60 years and older. Little is known about the implications for blacks. METHODS AND RESULTS: Using data from 2000 through 2011 for 5280 participants in the Jackson Heart Study, a community-based black cohort in Jackson, Mississippi, we examined whether higher blood pressure was associated with greater risk of mortality and heart failure hospitalization, and whether the risk was the same across age groups...
December 7, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27927029/measuring-wearing-time-of-knee-ankle-foot-orthoses-in-children-with-cerebral-palsy-comparison-of-parent-report-and-objective-measurement
#20
Josina C Maas, Annet J Dallmeijer, Bodil Y Oudshoorn, Eline A M Bolster, Peter A Huijing, Richard T Jaspers, Jules G Becher
: Purpose state: Orthotic wearing time may be an important confounder in efficacy studies of treatment in children with spastic cerebral palsy (SCP). Most studies measure parent-reported wearing time (WTparent) with questionnaires, but it is questionable whether this yields valid results. This study aims to compare WTparent with objectively measured wearing time (WTobj) in children with SCP receiving orthotic treatment. METHOD: Eight children with SCP participated in this observational study...
December 7, 2016: Disability and Rehabilitation
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