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https://www.readbyqxmd.com/read/28732335/characteristics-and-source-apportionment-of-pm2-5-during-persistent-extreme-haze-events-in-chengdu-southwest-china
#1
Lulu Li, Qinwen Tan, Yuanhang Zhang, Miao Feng, Yu Qu, Junling An, Xingang Liu
Based on detailed data from Chengdu Plain (CP) from 6 January to 16 January, two typical haze episodes were analyzed to clarify the haze formation mechanism in winter. Weather conditions, chemical compositions, secondary pollutant transformation, optical properties of aerosols, the potential source contribution function (PSCF) and source apportionment were studied. The planetary boundary layer (PBL) height decreased distinctly during the haze episodes and restrained air pollutant vertical dispersion. As the haze worsened, the value of PBL × PM2...
July 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28730302/internal-resources-among-informal-caregivers-trajectories-and-associations-with-well-being
#2
Kristin Litzelman, Gina Tesauro, Rebecca Ferrer
PURPOSE: The experiences, skills, and internal resources that informal caregivers bring into their role may play a critical part in their mental health and well-being. This study examined how caregiver internal resources changed over a 10 year period, and how this was related to caregivers' well-being. METHODS: Data are from the Midlife in the United States (MIDUS) study, a national sample of adults, at two time points: 1995-1996 (T1) and 2004-2006 (T2). We identified subjects who reported being a caregiver at T2 and starting care after T1 (mean age = 56; 65% female)...
July 20, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28727004/physiology-and-endocrinology-symposium-postnatal-reproductive-development-and-the-lactocrine-hypothesis
#3
F F Bartol, A A Wiley, A F George, D J Miller, C A Bagnell
Maternal effects on development can program cell fate and dictate offspring phenotype. Such effects do not end at birth, but extend into postnatal life through signals communicated from mother to offspring in first milk (colostrum). Transmission of bioactive factors from mother to offspring as a specific consequence of nursing defines a lactocrine mechanism. The female reproductive tract is not fully formed at birth (postnatal day = PND 0). Data for ungulates and mice indicate that disruption of development during neonatal life can have lasting effects on the form and function of uterine tissues...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726468/longitudinal-trajectories-of-benefit-finding-in-adolescents-with-type-1-diabetes
#4
Jessica Rassart, Koen Luyckx, Cynthia A Berg, Leen Oris, Deborah J Wiebe
OBJECTIVES: Benefit finding, which refers to perceiving positive life changes resulting from adversity, has been associated with better psychosocial well-being in different chronic illnesses. However, little research to date has examined how benefit finding develops in the context of Type 1 diabetes (T1D). The present study aimed to identify trajectories of benefit finding across adolescence and to investigate prospective associations with depressive symptoms, self-care, and metabolic control...
July 20, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28724145/tense-marking-in-the-english-narrative-retells-of-dual-language-preschoolers
#5
Svenja Gusewski, Raúl Rojas
Purpose: This longitudinal study investigated the emergence of English tense marking in young (Spanish-English) dual language learners (DLLs) over 4 consecutive academic semesters, addressing the need for longitudinal data on typical acquisition trajectories of English in DLL preschoolers. Method: Language sample analysis was conducted on 139 English narrative retells elicited from 39 preschool-age (Spanish-English) DLLs (range = 39-65 months). Growth curve models captured within- and between-individual change in tense-marking accuracy over time...
July 19, 2017: Language, Speech, and Hearing Services in Schools
https://www.readbyqxmd.com/read/28724075/a-comprehensive-image-based-phenomic-analysis-reveals-the-complex-genetic-architecture-of-shoot-growth-dynamics-in-rice-oryza-sativa
#6
Malachy T Campbell, Qian Du, Kan Liu, Chris J Brien, Bettina Berger, Chi Zhang, Harkamal Walia
Early vigor is an important trait for many rice ( L.)-growing environments. However, genetic characterization and improvement for early vigor is hindered by the temporal nature of the trait and strong genotype × environment effects. We explored the genetic architecture of shoot growth dynamics during the early and active tillering stages by applying a functional modeling and genomewide association (GWAS) mapping approach on a diversity panel of ∼360 rice accessions. Multiple loci with small effects on shoot growth trajectory were identified, indicating a complex polygenic architecture...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28720317/dcc-receptors-drive-prefrontal-cortex-maturation-by-determining-dopamine-axon%C3%A2-targeting-in-adolescence
#7
Lauren M Reynolds, Matthew Pokinko, Angélica Torres-Berrío, Santiago Cuesta, Laura C Lambert, Esther Del Cid Pellitero, Michael Wodzinski, Colleen Manitt, Paul Krimpenfort, Bryan Kolb, Cecilia Flores
BACKGROUND: Dopaminergic input to the prefrontal cortex (PFC) increases throughout adolescence and, by establishing precisely localized synapses, calibrates cognitive function. However, why and how mesocortical dopamine axon density increases across adolescence remains unknown. METHODS: We used a developmental application of axon-initiated recombination to label and track the growth of dopamine axons across adolescence in mice. We then paired this recombination with cell-specific knockdown of the netrin-1 receptor DCC to determine its role in adolescent dopamine axon growth...
June 16, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28720028/growth-of-word-and-pseudoword-reading-efficiency-in-alphabetic-orthographies-impact-of-consistency
#8
Markéta Caravolas
Word and pseudoword reading are related abilities fundamental to reading development in alphabetic orthographies. They are respectively assumed to index children's orthographic representations of words, which are in turn acquired through the underlying "self-teaching mechanism" of alphabetic pseudoword decoding. Little is known about concurrent growth trajectories of these skills in the early grades among children learning different alphabetic orthographies. In the present study, between- and within-group latent growth models of word and pseudoword reading efficiency were tested on data spanning Grades 1 and 2 from learners of the inconsistent English and consistent Czech and Slovak orthographies...
July 1, 2017: Journal of Learning Disabilities
https://www.readbyqxmd.com/read/28718326/cns-anticancer-drug-discovery-and-development-2016-conference-insights
#9
Victor A Levin, Lauren E Abrey, Timothy P Heffron, Peter J Tonge, Arvin C Dar, William A Weiss, James M Gallo
CNS Anticancer Drug Discovery and Development November 2016, AZ, USA The 2016 second CNS Anticancer Drug Discovery and Development Conference addressed diverse viewpoints about why new drug discovery/development focused on CNS cancers has been sorely lacking. Despite more than 70,000 individuals in the USA being diagnosed with a primary brain malignancy and 151,669-286,486 suffering from metastatic CNS cancer, in 1999, temozolomide was the last drug approved by the US FDA as an anticancer agent for high-grade gliomas...
July 18, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28717815/hip-fractures-in-older-patients-trajectories-of-disability-after-surgery
#10
J J Aarden, M van der Esch, R H H Engelbert, M van der Schaaf, S E de Rooij, B M Buurman
BACKGROUND: Hip fracture in older patients often lead to permanent disabilities and can result in mortality. OBJECTIVE: To identify distinct disability trajectories from admission to one-year post-discharge in acutely hospitalized older patients after hip fracture. DESIGN: Prospective cohort study, with assessments at admission, three-months and one-year post-discharge. SETTING AND PARTICIPANTS: Patients ≥ 65 years admitted to a 1024-bed tertiary teaching hospital in the Netherlands...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28717387/human-mediated-evolution-in-a-threatened-species-juvenile-life-history-changes-in-snake-river-salmon
#11
Robin S Waples, Anna Elz, Billy D Arnsberg, James R Faulkner, Jeffrey J Hard, Emma Timmins-Schiffman, Linda K Park
Evaluations of human impacts on Earth's ecosystems often ignore evolutionary changes in response to altered selective regimes. Freshwater habitats for Snake River fall Chinook salmon (SRFCS), a threatened species in the US, have been dramatically changed by hydropower development and other watershed modifications. Associated biological changes include a shift in juvenile life history: Historically essentially 100% of juveniles migrated to sea as subyearlings, but a substantial fraction have migrated as yearlings in recent years...
August 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28714990/an-approach-to-suppress-the-evolution-of-resistance-in-braf-v600e-mutant-cancer
#12
Yaohua Xue, Luciano Martelotto, Timour Baslan, Alberto Vides, Martha Solomon, Trang Thi Mai, Neelam Chaudhary, Greg J Riely, Bob T Li, Kerry Scott, Fabiola Cechhi, Ulrika Stierner, Kalyani Chadalavada, Elisa de Stanchina, Sarit Schwartz, Todd Hembrough, Gouri Nanjangud, Michael F Berger, Jonas Nilsson, Scott W Lowe, Jorge S Reis-Filho, Neal Rosen, Piro Lito
The principles that govern the evolution of tumors exposed to targeted therapy are poorly understood. Here we modeled the selection and propagation of an amplification in the BRAF oncogene (BRAF(amp)) in patient-derived tumor xenografts (PDXs) that were treated with a direct inhibitor of the kinase ERK, either alone or in combination with other ERK signaling inhibitors. Single-cell sequencing and multiplex fluorescence in situ hybridization analyses mapped the emergence of extra-chromosomal amplification in parallel evolutionary trajectories that arose in the same tumor shortly after treatment...
July 17, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28713396/system-level-and-granger-network-analysis-of-integrated-proteomic-and-metabolomic-dynamics-identifies-key-points-of-grape-berry-development-at-the-interface-of-primary-and-secondary-metabolism
#13
Lei Wang, Xiaoliang Sun, Jakob Weiszmann, Wolfram Weckwerth
Grapevine is a fruit crop with worldwide economic importance. The grape berry undergoes complex biochemical changes from fruit set until ripening. This ripening process and production processes define the wine quality. Thus, a thorough understanding of berry ripening is crucial for the prediction of wine quality. For a systemic analysis of grape berry development we applied mass spectrometry based platforms to analyse the metabolome and proteome of Early Campbell at 12 stages covering major developmental phases...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28711396/social-adversity-in-pregnancy-and-trajectories-of-women-s-depressive-symptoms-a-longitudinal-study
#14
Ann M Kingsbury, Maria Plotnikova, Alexandra Clavarino, Abullah Mamun, Jake M Najman
BACKGROUND: Sound evidence has linked the experience of adversity with depression. Less is known about this association over time. AIM: The aim of this study is to determine whether or not social adversity experienced by pregnant women is associated with their patterns of depressive symptoms over their reproductive life course. METHODS: Data were obtained from a cohort of women collected at their first obstetrical clinic visit of an index pregnancy (time-point 1) and at a further six time-points to 27 years following the birth...
July 12, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28709229/phenomenology-of-stochastic-exponential-growth
#15
Dan Pirjol, Farshid Jafarpour, Srividya Iyer-Biswas
Stochastic exponential growth is observed in a variety of contexts, including molecular autocatalysis, nuclear fission, population growth, inflation of the universe, viral social media posts, and financial markets. Yet literature on modeling the phenomenology of these stochastic dynamics has predominantly focused on one model, geometric Brownian motion (GBM), which can be described as the solution of a Langevin equation with linear drift and linear multiplicative noise. Using recent experimental results on stochastic exponential growth of individual bacterial cell sizes, we motivate the need for a more general class of phenomenological models of stochastic exponential growth, which are consistent with the observation that the mean-rescaled distributions are approximately stationary at long times...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28707388/the-associations-of-large-for-gestational-age-and-infant-feeding-practices-with-children-s-body-mass-index-z-score-trajectories-the-early-childhood-longitudinal-study-birth-cohort
#16
M Salahuddin, A Pérez, N Ranjit, D M Hoelscher, S H Kelder
Very few studies have examined if high birth weight and infant feeding practices have implications for the trajectory of body mass index (BMI) growth across the early childhood period. The goal of this study was to assess if large-for-gestational-age (LGA) and infant feeding practices (exclusive breastfeeding for 6 months, and early introduction of complementary food prior to 4 months) are associated with BMI z-score trajectories over the early childhood period. Group-based trajectory modelling (GBTM) methods were employed to describe and classify developmental BMI z-score trajectories (the outcome of interest) in children from 9 months to 4 years of age (n = 4497) born to prenatal non-smoking mothers in the Early Childhood Longitudinal Study, Birth Cohort (2001-2005)...
July 14, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28707156/trajectories-of-mood-and-stress-and-relationships-with-protective-factors-during-the-transition-to-menopause-results-using-latent-class-growth-modeling-in-a-canadian-cohort
#17
Eva Guérin, Gary Goldfield, Denis Prud'homme
The menopause transition is characterized by significant hormonal changes that may predispose women to psychosocial maladjustment. Prospective studies to date have focused primarily on negative mood states and show equivocal findings. The primary goal of this study was to identify patterns of change with respect to positive and negative mood states (vigor, depression, tension, and stress) over a 5-year period in a cohort of women undergoing the transition to menopause. A secondary aim was to determine whether the identified trajectories were associated with menopause status as well as baseline health-related and psychological characteristics...
July 13, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28706228/analysing-the-natural-population-growth-of-a-large-marine-mammal-after-a-depletive-harvest
#18
M A Romero, M F Grandi, M Koen-Alonso, G Svendsen, M Ocampo Reinaldo, N A García, S L Dans, R González, E A Crespo
An understanding of the underlying processes and comprehensive history of population growth after a harvest-driven depletion is necessary when assessing the long-term effectiveness of management and conservation strategies. The South American sea lion (SASL), Otaria flavescens, is the most conspicuous marine mammal along the South American coasts, where it has been heavily exploited. As a consequence of this exploitation, many of its populations were decimated during the early 20th century but currently show a clear recovery...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28705357/trajectories-of-neighborhood-attainment-after-prison
#19
Keunbok Lee, David J Harding, Jeffrey D Morenoff
A potentially important but understudied aspect of prisoner reentry is the neighborhood environments experienced by formerly incarcerated people. We know that many formerly incarcerated people return to very disadvantaged neighborhood environments and that returning to disadvantaged neighborhoods after prison increases the risk of recidivism and reduces employment. Yet very little is known about the social, economic, and institutional processes that sort formerly incarcerated people into different neighborhoods after release or their trajectories of neighborhood attainment over time...
August 2017: Social Science Research
https://www.readbyqxmd.com/read/28705350/trajectories-of-relationship-supportiveness-after-childbirth-does-marriage-matter
#20
Marcia J Carlson, Alicia G VanOrman
Relationship quality for married couples typically declines after the birth of a (first) child, as parenthood brings new identities, stresses, and responsibilities for mothers and fathers. Yet, it is less clear whether nonmarital relationship quality follows a similar trajectory, particularly given the greater selectivity of nonmarital relationships that persist over time. This paper uses data from the Fragile Families and Child Wellbeing Study (N = 3,459) with latent growth curve models to examine relationship quality (measured by mothers' perceived supportiveness about fathers) for married and unmarried couples over nine years after a child's birth...
August 2017: Social Science Research
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