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https://www.readbyqxmd.com/read/29048488/clinical-and-molecular-features-of-mdr-livestock-associated-mrsa-st9-with-staphylococcal-cassette-chromosome-mecxii-in-humans
#1
Chih-Jung Chen, Tsai-Ling Yang Lauderdale, Chin-Te Lu, Yu-Yu Chuang, Chien-Chang Yang, Ting-Shu Wu, Chun-Yi Lee, Min-Chi Lu, Wen-Chien Ko, Yhu-Chering Huang
Objectives: Clonal complex (CC) 9 is a prevalent livestock-associated (LA) MRSA clone in Asia whose pathogenicity in humans remains unknown. Methods: In 2012, we identified a patient with CC9-MRSA infection linked to livestock. After screening 3328 clinical MRSA isolates from a national database, eight isolates (0.24%) collected between 1998 and 2012 were further confirmed to be of CC9. The detailed molecular features of the nine human CC9 strains and phylogenetic relatedness to animal CC9 strains were characterized with WGS...
October 18, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29046259/assessing-the-impact-of-quality-improvement-measures-on-catheter-related-blood-stream-infections-and-catheter-salvage-experience-from-a-national-intestinal-failure-unit
#2
A Bond, A Teubner, M Taylor, C Cawley, A Abraham, M Dibb, P R Chadwick, M Soop, G Carlson, S Lal
BACKGROUND & AIMS: Prevention of catheter related blood stream infections (CRBSI) and salvage of infected central venous catheters (CVC) are vital to maintaining long term venous access in patients needing home parenteral nutrition (HPN). It remains unclear as to whether patients are best trained for catheter care at home or in hospital or whether CRBSIs are lower if the patient self-cares for the CVC. Furthermore, there is minimal data on the longer term outcome following salvage of infected catheter and limited consensus on agreed protocols for catheter salvage...
October 10, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29045648/staphylococcus-aureus-bloodstream-infections-in-latin-america-results-of-a-multinational-prospective-cohort-study
#3
Carlos Seas, Coralith Garcia, Mauro J Salles, Jaime Labarca, Carlos Luna, Carlos Alvarez-Moreno, Carlos Mejía-Villatoro, Jeannete Zurita, Manuel Guzmán-Blanco, Eduardo Rodríguez-Noriega, Jinnethe Reyes, Cesar A Arias, Cesar Carcamo, Eduardo Gotuzzo
Background: Substantial heterogeneity in the epidemiology and management of Staphylococcus aureus bacteraemia (SAB) occurs in Latin America. We conducted a prospective cohort study in 24 hospitals from nine Latin American countries. Objectives: To assess the clinical impact of SAB in Latin America. Patients and methods: We evaluated differences in the 30 day attributable mortality among patients with SAB due to MRSA compared with MSSA involving 84 days of follow-up...
October 17, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29043959/purified-citritin-in-combination-with-vancomycin-inhibits-vre-in-vitro-and-in-vivo
#4
Kléber de Sousa Oliveira, Paulo Roberto Martins Queiroz, Isabel Cristina Marques Fensterseifer, Ludovico Migliolo, Aline Lima Oliveira, Octávio Luiz Franco
Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) have been frequently associated with bacterial resistance mechanisms. These mechanisms, in turn, restrict a range of therapeutic opportunities for the treatment of infections caused by these micro-organisms. Faced with this problem, the present study aims to isolate and characterize molecules with antimicrobial activity derived from the fungus Penicillium citrinum isolated from Cerrado soil...
October 18, 2017: Microbiology
https://www.readbyqxmd.com/read/29042801/investigating-a-rare-methicillin-resistant-staphylococcus-aureus-strain-first-description-of-genome-sequencing-and-molecular-characterization-of-cc15-mrsa
#5
Abiola C Senok, Ali M Somily, Peter Slickers, Muhabat A Raji, Ghada Garaween, Atef Shibl, Stefan Monecke, Ralf Ehricht
PURPOSE: Methicillin resistant Staphylococcus aureus CC15 strains (CC15-MRSA) have only been sporadically described in literature. This study was carried out to describe the genetic make-up for this rare MRSA strain. METHODS: Four CC15-MRSA isolates collected in Riyadh, Saudi Arabia, between 2013 and 2014 were studied. Two isolates were from clinical infection and 2 from retail meat products. Whole genome sequencing was carried out using Illumina HiSeq2500 genome analyzer...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29039613/staphylococcus-aureus-colonisation-in-patients-from-a-primary-regional-hospital
#6
Anca Ungureanu, Ovidiu Zlatian, George Mitroi, Andrei Drocaş, Tiberiu Ţîrcă, Daniela Călina, Cristina Dehelean, Anca Oana Docea, Boris N Izotov, Valerii N Rakitskii, Ramona Cioboată, Demetrios A Spandidos, Aristides M Tsatsakis, Alice Găman
Staphylococcus aureus (SA or S. aureus) is a common pathogen that leads to local and systemic infections in communitarian and hospitalised patients. Staphylococcus colonizing nasal or pharyngeal sites can become virulent and cause severe infections. In this study, we collected 322 pharyngeal exudates and 142 nasal exudates from hospitalised and outpatients for screening purposes. The carriage rates in the pharynx were 27.06% for S. aureus, 11.55% for methicillin‑resistant S. aureus (MRSA) and 5.61% for methicillin‑oxacillin resistant S...
October 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038267/a-retrospective-analysis-of-treatment-and-clinical-outcomes-among-patients-with-methicillin-susceptible-staphylococcus-aureus-bloodstream-isolates-possessing-detectable-meca-by-a-commercial-pcr-assay-compared-to-patients-with-methicillin-resistant-staphylococcus
#7
Dylan Jones, Ramy H Elshaboury, Erik Munson, Thomas J Dilworth
mecA-positive Staphylococcus aureus isolates phenotypically susceptible to cefoxitin (mecA-MSSA) have been identified. We describe treatment and outcomes among patients with mecA-MSSA bloodstream infections (BSI) and MRSA BSI patients matched 1:1 on age, BSI origin and BSI type (n=17 per group). Compared to MRSA BSI patients, mecA-MSSA BSI patients more often experienced clinical failure (58.8% and 11.8%, p=0.010), driven largely by persistent bacteremia (35.3% and 11.8%). mecA-MSSA BSI patients may be at higher risk for poor clinical outcomes...
October 16, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29036196/understanding-the-antimicrobial-activity-of-selected-disinfectants-against-methicillin-resistant-staphylococcus-aureus-mrsa
#8
Ebrahim Aboualizadeh, Violet V Bumah, Daniela S Masson-Meyers, Janis T Eells, Carol J Hirschmugl, Chukuka S Enwemeka
Disinfectants and biocidal products have been widely used to combat Methicillin-resistant Staphylococcus aureus (MRSA) infections in homes and healthcare environments. Although disruption of cytoplasmic membrane integrity has been documented as the main bactericidal effect of biocides, little is known about the biochemical alterations induced by these chemical agents. In this study, we used Fourier transform infrared (FT-IR) spectroscopy and chemometric tools as an alternative non-destructive technique to determine the bactericidal effects of commonly used disinfectants against MRSA USA-300...
2017: PloS One
https://www.readbyqxmd.com/read/29031863/validation-of-healthcare-associated-infection-surveillance-in-smaller-australian-hospitals
#9
A Hoskins, L J Worth, N Imam, S A Johnson, A Bull, M J Richards, N Bennett
A validation study was conducted in smaller (<100 acute beds) Victorian hospitals to evaluate case-detection for Staphylococcus aureus bloodstream (SAB), methicillin-resistant S. aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) infections. Overall, 142 infections were identified in 20 hospitals. For routine surveillance of SAB events sensitivity was 74.4% and specificity was 100.0%. For MRSA infections, sensitivity was 47.5% and specificity was 90.9%. All confirmed VRE infections were correctly reported...
October 12, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29031827/development-of-a-surgical-site-infection-prediction-model-in-orthopaedic-trauma-the-denver-health-model
#10
Sara M Reese, Bryan Knepper, Heather L Young, Cyril Mauffrey
BACKGROUND: The CDC's National Healthcare Safety Network's (NHSN) current risk adjustment model for surgical site infections (SSI) following open reduction internal fixation (ORIF) of long bone fractures is a suboptimal predictor of risk. We hypothesized that by including variables known to be associated with SSI following ORIF, we would develop a model that would increase the accuracy and predictability of SSI risk. METHODS: Patients who underwent ORIF of a long bone between January 1, 2012 and December 31, 2014 were included in the study (n=1543)...
October 9, 2017: Injury
https://www.readbyqxmd.com/read/29031432/discontinuing-contact-precautions-for-multidrug-resistant-organisms-a-systematic-literature-review-and-meta-analysis
#11
Alexandre R Marra, Michael B Edmond, Marin L Schweizer, Grace W Ryan, Daniel J Diekema
BACKGROUND: Several single-center studies have suggested that eliminating contact precautions (CPs) for methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) control in nonoutbreak settings has no impact on infection rates. We performed a systematic literature review and meta-analysis on the impact of discontinuing contact precautions in the acute care setting. METHODS: We searched PubMed, CINAHL, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, and Embase through December 2016 for studies evaluating discontinuation of contact precautions for multidrug-resistant organisms...
October 11, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29029278/efficacy-and-safety-of-delafloxacin-compared-with-vancomycin-plus-aztreonam-for-acute-bacterial-skin-and-skin-structure-infections-a-phase-3-double-blind-randomized-study
#12
J Pullman, J Gardovskis, B Farley, E Sun, M Quintas, L Lawrence, R Ling, S Cammarata
Background: Delafloxacin is an investigational anionic fluoroquinolone in development for oral or intravenous administration for the treatment of infections caused by Gram-positive (including MRSA), Gram-negative, atypical and anaerobic organisms. Objectives: To establish the non-inferiority of delafloxacin compared with vancomycin plus aztreonam for the treatment of acute bacterial skin and skin structure infections and to compare the safety of the two antimicrobials...
October 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29026654/population-genetic-structuring-of-methicillin-resistant-staphylococcus-aureus-clone-emrsa-15-within-uk-reflects-patient-referral-patterns
#13
Tjibbe Donker, Sandra Reuter, James Scriberras, Rosy Reynolds, Nicholas M Brown, M Estée Török, Richard James, East Of England Microbiology Research Network, David M Aanensen, Stephen D Bentley, Matthew T G Holden, Julian Parkhill, Brian G Spratt, Sharon J Peacock, Edward J Feil, Hajo Grundmann
Antibiotic resistance forms a serious threat to the health of hospitalised patients, rendering otherwise treatable bacterial infections potentially life-threatening. A thorough understanding of the mechanisms by which resistance spreads between patients in different hospitals is required in order to design effective control strategies. We measured the differences between bacterial populations of 52 hospitals in the United Kingdom and Ireland, using whole-genome sequences from 1085 MRSA clonal complex 22 isolates collected between 1998 and 2012...
July 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29025325/versatility-of-targeted-antibiotic-loaded-gold-nanoconstructs-for-the-treatment-of-biofilm-associated-bacterial-infections
#14
Daniel G Meeker, Tengjiao Wang, Walter N Harrington, Vladimir P Zharov, Sarah A Johnson, Samir V Jenkins, Stephanie E Oyibo, Christopher M Walker, Weston B Mills, Mark E Shirtliff, Karen E Beenken, Jingyi Chen, Mark S Smeltzer
BACKGROUND: We previously demonstrated that a photoactivatable therapeutic approach employing antibiotic-loaded, antibody-conjugated, polydopamine (PDA)-coated gold nanocages (AuNCs) could be used for the synergistic killing of bacterial cells within a biofilm. The approach was validated with a focus on Staphylococcus aureus using an antibody specific for staphylococcal protein A (Spa) and an antibiotic (daptomycin) active against Gram-positive cocci including methicillin-resistant S...
October 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29020940/the-epidemiology-and-transmission-of-methicillin-resistant-staphylococcus-aureus-in-the-community-in-singapore-study-protocol-for-a-longitudinal-household-study
#15
Nivedita Shankar, Angela Li Ping Chow, Jolene Oon, Li Yang Hsu, Brenda Ang, Junxiong Pang, Paola Florez De Sessions, Balamurugan Periaswamy, Paul A Tambyah, Desmond B Teo, Clarence C Tam
BACKGROUND/AIM: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common multidrug-resistant organisms in healthcare settings worldwide, but little is known about MRSA transmission outside of acute healthcare settings especially in Asia. We describe the methods for a prospective longitudinal study of MRSA prevalence and transmission. METHODS: MRSA-colonized individuals were identified from MRSA admission screening at two tertiary hospitals and recruited together with their household contacts...
October 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29020322/trends-in-methicillin-resistant-staphylococcus-aureus-hospitalizations-in-the-united-states-2010-2014
#16
Eili Y Klein, Nestor Mojica, Wendi Jiang, Sara E Cosgrove, Edward Septimus, Daniel J Morgan, Ramanan Laxminarayan
Reports have suggested declines in incidence of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections. Our analysis of data from the National Inpatient Sample shows that the decrease in MRSA-related hospitalizations between 2010 and 2014 was primarily due to declines in skin- and soft-tissue infections. Invasive MRSA-related hospitalizations remained largely unchanged.
July 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28994446/colonization-of-residents-and-staff-of-an-italian-long-term-care-facility-and-an-adjacent-acute-care-hospital-geriatric-unit-by-multidrug-resistant-bacteria
#17
Albert March, Richard Aschbacher, Ferisa Sleghel, Gertrud Soelva, Malgorzata Kaczor, Roberta Migliavacca, Aurora Piazza, Vittoria Mattioni Marchetti, Laura Pagani, Katia Scalzo, Valentina Pasquetto, Elisabetta Pagani
In 2016, we undertook a point prevalence screening study for Enterobacteriaceae with extended-spectrum β-lactamases (ESBLs), high-level AmpC cephalosporinases and carbapenemases, and also methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE) in a long-term care facility (LTCF) and the associated acute care hospital geriatric unit in Bolzano, Northern Italy. Urine samples and rectal, inguinal, oropharyngeal and nasal swabs were plated on selective agars. Demographic data were collected...
October 10, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28992569/4-alkyliden-azetidinones-modified-with-plant-derived-polyphenols-antibacterial-and-antioxidant-properties
#18
Daria Giacomini, Rosario Musumeci, Paola Galletti, Giulia Martelli, Lorenzo Assennato, Gianni Sacchetti, Alessandra Guerrini, Enrico Calaresu, Marianna Martinelli, Clementina Cocuzza
Antimicrobial resistance is one of the major and growing concerns in hospital- and community acquired infections, and new antimicrobial agents are therefore urgently required. It was reported that oxidative stress could contribute to the selection of resistant bacterial strains, since reactive oxygen species (ROS) revealed to be an essential driving force. In the present work 4-alkylidene-azetidinones, a new class of antibacterial agents, were functionalized with phytochemical polyphenolic acids such as protocatechuic, piperonyl, caffeic, ferulic, or sinapic acids and investigated as dual target antibacterial-antioxidant compounds...
September 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28991759/the-importance-of-perioperative-prophylaxis-with-cefuroxime-or-ceftriaxone-in-the-surgical-site-infections-prevention-after-cranial-and-spinal-neurosurgical-procedures
#19
Aleksandra Dimovska-Gavrilovska, Aleksandar Chaparoski, Andreja Gavrilovski, Zvonko Milenkovikj
Introduction Surgical site infections pose a significant problem in the treatment of neurosurgical procedures, regardless of the application of perioperative prophylaxis with systemic antibiotics. The infection rate in these procedures ranges from less than 1% to above 15%. Different antibiotics and administration regimes have been used in the perioperative prophylaxis so far, and there are numerous comparative studies regarding their efficiency, however, it is generally indicated that the choice thereof should be based on information and local specifics connected to the most probable bacterial causers, which would possibly contaminate the surgical site and cause infection, and moreover, the mandatory compliance with the principles of providing adequate concentration of the drug at the time of the anticipated contamination...
September 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28991319/-etiology-and-evolution-of-the-osteoarticular-infections-2009-2015-pediatric-hospital-pereira-rossell-uruguay
#20
Carlos Zuníno, Alejandra Vomero, Soledad Pandolfo, Claudia Gutiérrez, Gabriela Algorta, M Catalina Pírez, Gustavo Giachetto
BACKGROUND: The most frequent osteoarticular infections (OAI) etiological agent is Staphylococcus aureus. The prevalence of other microorganisms has changed after the introduction of new vaccines. AIM: To describe the etiology and evolution of the OAIs in children hospitalized in Pediatric Hospital Pereira Rossell between 2009 and 2015. PATIENTS AND METHODS: Joint fluid and bone puncture studies of hospitalized children suspected of OAI. Epidemiological characteristics, isolated microorganisms, complementary tests, initial treatment, complications, and days of hospitalization were analyzed...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
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