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https://www.readbyqxmd.com/read/28089736/antibacterial-activity-of-limonium-brasiliense-baicuru-against-multidrug-resistant-bacteria-using-a-statistical-mixture-design
#1
Andressa Blainski, Barbara Gionco, Admilton G Oliveira, Galdino Andrade, Ieda S Scarminio, Denise B Silva, Norberto P Lopes, João C P Mello
ETHNOPHARMACOLOGICAL RELEVANCE: Limonium brasiliense (Boiss.) Kuntze (Plumbaginaceae) is commonly known as "baicuru" or "guaicuru" and preparations of its dried rhizomes have been populary used in the treatment of premenstrual syndrome and menstrual disorder, and as an antiseptic in genito-urinary infections. This study evaluated the potential antibacterial activity of rhizome extracts against multidrug-resistant bacterial strains using statistical mixture design. MATERIALS AND METHODS: The statistical design of four components (water, methanol, acetone and ethanol) produced 15 different extracts and also a confirmatory experiment, which was performed using water:acetone (3:7, v/v)...
January 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28087612/biofilm-formation-and-antimicrobial-resistance-genes-of-coagulase-negative-staphylococci-isolated-from-cows-with-mastitis-in-argentina
#2
Mariela E Srednik, Yannick D N Tremblay, Josée Labrie, Marie Archambault, Mario Jacques, Fernández Cirelli Alicia, Elida R Gentilini
Mastitis affects the health and welfare of dairy cows worldwide. Coagulase-negative staphylococci (CNS) are known to form biofilms and are increasingly recognized as a cause of persistent bovine intramammary infections. A total of 90 CNS isolated from cows with clinical and subclinical mastitis in Argentina from 2008-2014 were identified by PCR-RFLP using the gap gene. Standard microtiter plate assays were used to assess CNS biofilm formation and Staphylococcus haemolyticus species formed the strongest biofilms...
January 12, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28087406/erythrocyte-membrane-coated-nanogel-for-combinatorial-antivirulence-and-responsive-antimicrobial-delivery-against-staphylococcus-aureus-infection
#3
Yue Zhang, Jianhua Zhang, Wangsong Chen, Pavimol Angsantikul, Kevin A Spiekermann, Ronnie H Fang, Weiwei Gao, Liangfang Zhang
We reported an erythrocyte membrane-coated nanogel (RBC-nanogel) system with combinatorial antivirulence and responsive antibiotic delivery for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection. RBC membrane was coated onto the nanogel via a membrane vesicle templated in situ gelation process, whereas the redox-responsiveness was achieved by using a disulfide bond-based crosslinker. We demonstrated that the RBC-nanogels effectively neutralized MRSA-associated toxins in extracellular environment and the toxin neutralization in turn promoted bacterial uptake by macrophages...
January 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28081583/-early-results-of-adjuvant-topical-treatment-of-recurrent-osteomyelitis-with-absorbable-antibiotic-carriers
#4
Y Gramlich, G Walter, J Gils, R Hoffmann
Background Treatment of musculoskeletal infections principally consists of radical surgical debridement and systemic administration of antibiotics. Additional local antibiotic therapy is not yet generally established, and lacks evidence-based proof of efficacy. Nonetheless, there are a variety of practical approaches, as most specialised departments are unwilling to forego this option. The established polymethylmetacrylate (PMMA) carrier system has a number of practical disadvantages. This has led to the increased use of absorbable carrier systems, and those based on calcium sulphate have given particularly encouraging results...
January 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28081265/the-plasmin-sensitive-protein-pls-in-methicillin-resistant-staphylococcus-aureus-mrsa-is-a-glycoprotein
#5
Isabelle Bleiziffer, Julian Eikmeier, Gottfried Pohlentz, Kathryn McAulay, Guoqing Xia, Muzaffar Hussain, Andreas Peschel, Simon Foster, Georg Peters, Christine Heilmann
Most bacterial glycoproteins identified to date are virulence factors of pathogenic bacteria, i.e. adhesins and invasins. However, the impact of protein glycosylation on the major human pathogen Staphylococcus aureus remains incompletely understood. To study protein glycosylation in staphylococci, we analyzed lysostaphin lysates of methicillin-resistant Staphylococcus aureus (MRSA) strains by SDS-PAGE and subsequent periodic acid-Schiff's staining. We detected four (>300, ∼250, ∼165, and ∼120 kDa) and two (>300 and ∼175 kDa) glycosylated surface proteins with strain COL and strain 1061, respectively...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28079631/the-role-of-methicillin-resistant-staphylococcus-aureus-in-skin-and-soft-tissue-infections
#6
Matteo Bassetti, Alessia Carnelutti, Elda Righi
PURPOSE OF REVIEW: Methicillin-resistant Staphylococcus aureus (MRSA) has become a major public health issue worldwide over the last years. MRSA is frequently implicated in the development of skin and soft tissue infections, leading to significant increases in morbidity, mortality and overall healthcare costs. RECENT FINDINGS: In order to face the threat of MRSA, major changes in clinical management of skin and soft tissue infections are required. The identification of populations at risk for the acquisition of infections due to MRSA, together with the improvement of the diagnostic techniques, is paramount...
January 12, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28078661/role-of-cytokines-in-host-defense-against-staphylococcus-aureus-skin-infection
#7
REVIEW
Guosheng Wu, Banghui Zhu, Xudong Hong, Pengfei Luo, Zhaofan Xia
Wound infection caused by Staphylococcus aureus (S. aureus) is a critical clinical problem due to long hospitalization times, significant morbidity and mortality, as well as considerable medical resource consumption. With the emergence of methicillin-resistant S. aureus (MRSA) strains, current antibiotic treatments are becoming ineffective in combatting S. aureus infection. Thus, a novel therapeutic strategy is required. Recent studies discovered that several cytokines in the infected wound area play protective roles against S...
January 12, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28077586/redeploying-%C3%AE-lactam-antibiotics-as-a-novel-antivirulence-strategy-for-the-treatment-of-methicillin-resistant-staphylococcus-aureus-infections
#8
Elaine M Waters, Justine K Rudkin, Simone Coughlan, Geremy C Clair, Joshua N Adkins, Suzanna Gore, Guoqing Xia, Nikki S Black, Tim Downing, Eoghan O'Neill, Aras Kadioglu, James P O'Gara
Innovative approaches to the use of existing antibiotics is an important strategy in efforts to address the escalating antimicrobial resistance crisis. We report a new approach to the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections by demonstrating that oxacillin can be used to significantly attenuate the virulence of MRSA despite the pathogen being resistant to this drug. Using mechanistic in vitro assays and in vivo models of invasive pneumonia and sepsis, we show that oxacillin-treated MRSA strains are significantly attenuated in virulence...
January 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28073963/in-vitro-activity-of-daptomycin-combined-with-dalbavancin-and-linezolid-and-dalbavancin-with-linezolid-against-mrsa-strains
#9
Gulseren Aktas, Sengul Derbentli
OBJECTIVES: Combination therapies have a distinct advantage over monotherapies in terms of their broad spectrum, synergistic effect and prevention of the emergence of drug resistance. In the present study, the in vitro antibacterial activity of daptomycin combinations with linezolid and dalbavancin, and dalbavancin with linezolid were evaluated against 30 clinical MRSA strains. METHODS: The MICs of all antibiotics were determined using microbroth dilution as described by the CLSI...
September 28, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28068600/design-synthesis-and-antibacterial-evaluation-of-novel-pleuromutilin-derivatives-possessing-piperazine-linker
#10
Mei-Ling Gao, Jie Zeng, Xi Fang, Jian Luo, Zhen Jin, Ya-Hong Liu, You-Zhi Tang
A series of pleuromutilin derivatives bearing piperazine ring have been reported. The in vitro antibacterial activities of the synthetic derivatives against MRSA (ATCC 43300), Staphylococcus aureus (ATCC 29213), Enterococcus faecalis (ATCC 29212), Enterococcus faecium (ATCC35667) and Escherichia coli (ATCC25922) were evaluated by the broth dilution method. Most of the synthesized derivatives displayed potent activities. Compounds 11c, 12a and 12c were found to be the most active antibacterial derivatives against MRSA (minimum inhibitory concentration = 0...
January 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28067286/a-novel-chimeric-lysin-with-robust-antibacterial-activity-against-planktonic-and-biofilm-methicillin-resistant-staphylococcus-aureus
#11
Hang Yang, Huaidong Zhang, Jing Wang, Junping Yu, Hongping Wei
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most threatening pathogens due to its multi-drug resistance (MDR) and strong biofilm-forming capacity. Here, we described the screening of a novel chimeolysin (ClyF) that was active against planktonic and biofilm MRSA. Biochemical tests showed that ClyF was active against all S. aureus clinical isolates tested under planktonic and biofilm conditions. Structure analysis revealed that ClyF has an enhanced thermostability and pH tolerance than its parental lysin Pc by forming a hydrophobic cleft in the catalytic domain and an Ig-like structure in the cell-wall binding domain...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28066967/artepillin-c-and-phenolic-compounds-responsible-for-antimicrobial-and-antioxidant-activity-of-green-propolis-and-baccharis-dracunculifolia-dc
#12
R S Veiga, S Mendonça, P B Mendes, N Paulino, M J Mimica, A A Lagareiro Netto, I S Lira, B G C López, V Negrão, M C Marcucci
AIMS: This study investigates the antimicrobial activity in Staphylococcus aureus isolates (MSSA - Methicillin Sensitive Staphylococcus aureus and MRSA - Methicillin Resistant Staphylococcus aureus) and antioxidant activity of green propolis, Baccharis dracunculifolia DC extracts and Artepillin C(™) . METHODS AND RESULTS: The amount of Artepillin C in different extracts was determined by HPLC analysis. Minimum Inhibitory Concentrations 90 (MIC90) was determined using 40 isolates of Staphylococcus aureus inoculated in Müeller-Hinton agar culture medium containing the green-propolis and Baccharis dracunculifolia DC extracts...
January 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28066112/in-vitro-effectiveness-of-triterpenoids-and-their-synergistic-effect-with-antibiotics-against-staphylococcus-aureus-strains
#13
Muhammad Hamza, Maha Nadir, Nadir Mehmood, Adeel Farooq
OBJECTIVES: The aim of this study is to evaluate the effect of four triterpenoids such as oleanolic acid, ursolic acid, cycloastragenol, and beta-boswellic acid alone and in combination with antibiotics against Staphylococcus aureus strains. MATERIALS AND METHODS: Sixteen clinical strains of S. aureus from infected wounds were isolated. Eight were methicillin-sensitive S. aureus (MSSA), and the other eight were methicillin-resistant S. aureus (MRSA). The activity was also seen in reference S...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28065327/eight-years-of-decreased-methicillin-resistant-staphylococcus-aureus-health-care-associated-infections-associated-with-a-veterans-affairs-prevention-initiative
#14
Martin E Evans, Stephen M Kralovic, Loretta A Simbartl, Rajiv Jain, Gary A Roselle
BACKGROUND: Declines in methicillin-resistant Staphylococcus aureus (MRSA) health care associated infections (HAIs) were previously reported in Veterans Affairs acute care (2012), spinal cord injury (SCIU) (2011), and long-term-care facilities (LTCFs) (2012). Here we report continuing declines in infection rates in these settings through September 2015. METHODS: Monthly data entered into a national database from 127 acute care facilities, 22 SCIUs, and 133 LTCFs were evaluated for trends using negative binomial regression...
January 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28065202/using-positive-deviance-in-the-prevention-and-control-of-mrsa-infections-in-a-colombian-hospital-a-time-series-analysis
#15
N M Olarte Escobar, I A Valderrama Márquez, J Avila Quiroga, T Goretty Trujillo, F González, M I Garzón Aguilar, J Escobar-Pérez
Positive Deviance (PD) is a process to achieve a social and cultural change. This strategy has been used for the control of methicillin-resistant Staphylococcus aureus (MRSA) infection in some health institutions in the United States, but has rarely been adopted in institutions from developing countries where resources are limited. We describe our experience of PD in the control of healthcare-associated infections (HAIs) due to MRSA in a Colombian hospital with the aim of reducing HAI rates through a cultural change in processes...
January 9, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28064075/spectrally-resolved-infrared-microscopy-and-chemometric-tools-to-reveal-the-interaction-between-blue-light-470nm-and-methicillin-resistant-staphylococcus-aureus
#16
Violet V Bumah, Ebrahim Aboualizadeh, Daniela S Masson-Meyers, Janis T Eells, Chukuka S Enwemeka, Carol J Hirschmugl
Blue light inactivates methicillin-resistant Staphylococcus aureus (MRSA), a Gram-positive antibiotic resistant bacterium that leads to fatal infections; however, the mechanism of bacterial death remains unclear. In this paper, to uncover the mechanism underlying the bactericidal effect of blue light, a combination of Fourier transform infrared (FTIR) spectroscopy and chemometric tools is employed to detect the photoreactivity of MRSA and its distinctive pathway toward apoptosis after treatment. The mechanism of action of UV light and vancomycin against MRSA is also investigated to support the findings...
December 23, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28063000/evaluation-of-loop-mediated-isothermal-amplification-for-the-rapid-identification-of-bacteria-and-resistance-determinants-in-positive-blood-cultures
#17
J Rödel, J A Bohnert, S Stoll, L Wassill, B Edel, M Karrasch, B Löffler, W Pfister
The use of molecular assays to rapidly identify pathogens and resistance genes directly from positive blood cultures (BCs) contribute to shortening the time required for the diagnosis of bloodstream infections. In this work, loop-mediated isothermal amplification (LAMP) assays have been examined for their potential use in BC diagnosis. Three different assays were applied. The commercially available eazyplex® MRSA test detects Staphylococcus aureus, S. epidermidis, mecA, and mecC. Two in-house assays [Gram-positive (GP) and Gram-negative (GN)] have been developed for the detection of streptococci, enterococci, vanA, vanB, Pseudomonas spp...
January 6, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28061866/rapid-containment-of-nosocomial-transmission-of-a-rare-community-acquired-methicillin-resistant-staphylococcus-aureus-ca-mrsa-clone-responsible-for-the-staphylococcal-scalded-skin-syndrome-ssss
#18
Onofrio Lamanna, Dafne Bongiorno, Lisa Bertoncello, Stefano Grandesso, Sandra Mazzucato, Giovanni Battista Pozzan, Mario Cutrone, Michela Chirico, Flavia Baesso, Pierluigi Brugnaro, Viviana Cafiso, Stefania Stefani, Floriana Campanile
BACKGROUND: The aims of this study were to identify the source and the transmission pathway for a Staphylococcal Scalded Skin Syndrome (SSSS) outbreak in a maternity setting in Italy over 2 months, during 2014; to implement appropriate control measures in order to prevent the epidemic spread within the maternity ward; and to identify the Methicillin-Resistant Staphylococcus aureus (MRSA) epidemic clone. METHODS: Epidemiological and microbiological investigations, based on phenotyping and genotyping methods, were performed...
January 6, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28061827/systematic-review-and-network-meta-analysis-of-tedizolid-for-the-treatment-of-acute-bacterial-skin-and-skin-structure-infections-caused-by-mrsa
#19
Rachael McCool, Ian M Gould, Jacqui Eales, Teresa Barata, Mick Arber, Kelly Fleetwood, Julie Glanville, Teresa L Kauf
BACKGROUND: Tedizolid, the active moiety of tedizolid phosphate, is approved in the United States, the European Union, Canada and a number of other countries for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by certain susceptible bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). This network meta-analysis (NMA) evaluates the comparative effectiveness of tedizolid and other antibacterials indicated for the treatment of ABSSSI caused by MRSA...
January 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28060871/a-neonatal-murine-model-of-mrsa-pneumonia
#20
Elizabeth A Fitzpatrick, Dahui You, Bishwas Shrestha, David Siefker, Vivek S Patel, Nikki Yadav, Sridhar Jaligama, Stephania A Cormier
Pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of morbidity and mortality in infants particularly following lower respiratory tract viral infections such as Respiratory Syncytial Virus (RSV). However, the mechanisms by which co-infection of infants by MRSA and RSV cause increased lung pathology are unknown. Because the infant immune system is qualitatively and quantitatively different from adults we developed a model of infant MRSA pneumonia which will allow us to investigate the effects of RSV co-infection on disease severity...
2017: PloS One
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