keyword
https://read.qxmd.com/read/38547070/observation-of-key-phenological-stages-of-hemlock-woolly-adelgid-hemiptera-adelgidae-using-citizen-science-as-a-tool-to-inform-research-and-management
#21
JOURNAL ARTICLE
Nicholas J Dietschler, Tonya D Bittner, Marshall Bigler Lefebvre, Jasmine Schmidt, Carrie S Jubb, Aryanna James, Scott M Salom, Mark C Whitmore
Increasing efficiency of data gathering at the landscape scale on the growing number of pests and pathogens threatening forests worldwide has potential to improve management outcomes. Citizen science is expanding, with growing support and utility in environmental and conservation fields. We present a case study showing how citizen science observations can be used to inform research and management of a devastating forest pest. Hemlock woolly adelgid, Adelges tsugae Annand (Hemiptera: Adelgidae), was introduced to eastern North America, leading to decline and mortality of eastern [Tsuga canadensis (L...
March 28, 2024: Journal of Economic Entomology
https://read.qxmd.com/read/38547054/kombucha-tea-associated-microbes-remodel-host-metabolic-pathways-to-suppress-lipid-accumulation
#22
JOURNAL ARTICLE
Rachel N DuMez-Kornegay, Lillian S Baker, Alexis J Morris, Whitney L M DeLoach, Robert H Dowen
The popularity of the ancient, probiotic-rich beverage Kombucha Tea (KT) has surged in part due to its purported health benefits, which include protection against metabolic diseases; however, these claims have not been rigorously tested and the mechanisms underlying host response to the probiotics in KT are unknown. Here, we establish a reproducible method to maintain C. elegans on a diet exclusively consisting of Kombucha Tea-associated microbes (KTM), which mirrors the microbial community found in the fermenting culture...
March 2024: PLoS Genetics
https://read.qxmd.com/read/38547048/transcatheter-aortic-valve-replacement-in-a-patient-with-quadricuspid-aortic-valve-stenosis-and-regurgitation
#23
JOURNAL ARTICLE
Solomon W Bienstock, Parasuram Krishnamoorthy, Gilbert H L Tang, Stamatios Lerakis, Samin K Sharma, Annapoorna S Kini, Lucy M Safi
We report the case of an 80-year-old woman with known quadricuspid aortic valve (QAV), severe aortic stenosis, and moderate-to-severe regurgitation who recently underwent a transcatheter aortic valve replacement (TAVR).
March 26, 2024: Journal of Invasive Cardiology
https://read.qxmd.com/read/38547024/tuberculosis-united-states-2023
#24
JOURNAL ARTICLE
Paula M Williams, Robert H Pratt, William L Walker, Sandy F Price, Rebekah J Stewart, Pei-Jean I Feng
After 27 years of declining U.S. tuberculosis (TB) case counts, the number of TB cases declined considerably in 2020, coinciding with the COVID-19 pandemic. For this analysis, TB case counts were obtained from the National TB Surveillance System. U.S. Census Bureau population estimates were used to calculate rates overall, by jurisdiction, birth origin, race and ethnicity, and age group. Since 2020, TB case counts and rates have increased each year. During 2023, a total of 9,615 TB cases were provisionally reported by the 50 U...
March 28, 2024: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/38546955/primary-photophysical-and-photochemical-processes-for-cerium-ammonium-nitrate-can-in-acetonitrile
#25
JOURNAL ARTICLE
Roman G Fedunov, Ivan P Pozdnyakov, Aleksander V Mikheylis, Alexei A Melnikov, Sergei V Chekalin, Evgeni M Glebov
Cerium ammonium nitrate (CAN) is an important photolytic source of NO3 • radicals in aqueous nitric acid solutions and in acetonitrile. In this work we performed the study of primary photochemical processes for CAN in acetonitrile by means of ultrafast TA spectroscopy and quantum chemical calculations. Photoexcitation of CAN is followed by ultrafast (< 100 fs) intersystem crossing; the vibrationally cooled triplet state decays to pentacoordinated Ce(III) intermediate and NO3 • radical with the characteristic time of ca...
March 28, 2024: Photochemical & Photobiological Sciences
https://read.qxmd.com/read/38546940/effect-of-a-single-small-volume-fluid-bolus-with-balanced-or-un-balanced-fluids-on-chloride-and-acid-base-status-a-prospective-randomized-pilot-study-the-flures-trial
#26
JOURNAL ARTICLE
M Raes, J A Kellum, R Colman, S Wallaert, M Crivits, F Viaene, M Hemeryck, D Benoit, J Poelaert, E Hoste
OBJECTIVE: To compare the short-term effects on acid base, electrolyte status and urine output of a single fluid bolus of saline to that of the balanced solution Plasmalyte® in critically ill patients. METHODS: Prospective, randomized, controlled trial. Adult patients (≥ 18 years) admitted to the ICU receiving a fluid bolus were randomized to receive 1 L of saline (NaCl 0.9%, Baxter) or a balanced fluid [Plasmalyte® (Baxter)]. Blood samples and urine output were collected just before (T0), just after (T1), 2 h after (T2) (only for urinary output) and three hours after termination of the fluid bolus (T4)...
March 28, 2024: Journal of Nephrology
https://read.qxmd.com/read/38546931/high-frequency-of-transient-congenital-hypothyroidism-among-infants-referred-for-suspected-congenital-hypothyroidism-from-the-turkish-national-screening-program-thyroxine-dose-may-guide-the-prediction-of-transients
#27
JOURNAL ARTICLE
Y Özer, A Anık, U Sayılı, U Tercan, R Deveci Sevim, S Güneş, M Buhur Pirimoğlu, S Elmaoğulları, I Dündar, D Ökdemir, Ö Besci, A Jalilova, D Çiçek, B Singin, Ş E Ulu, H Turan, S Albayrak, Z Kocabey Sütçü, B S Eklioğlu, E Eren, S Çetinkaya, Ş Savaş-Erdeve, I Esen, K Demir, Ş Darcan, N Hatipoğlu, M Parlak, F Dursun, Z Şıklar, M Berberoğlu, M Keskin, Z Orbak, B Tezel, E Yürüker, B Keskinkılıç, F Kara, E Erginöz, F Darendeliler, O Evliyaoğlu
PURPOSE: We aimed to determine the frequency of transient congenital hypothyroidism (TCH) in 17 participating centers in Türkiye, evaluate the etiological distribution in permanent congenital hypothyroidism (PCH) cases, and investigate the role of laboratory and clinical findings in predicting TCH. METHODS: This retrospective observational multicenter study included patients from 17 pediatric endocrinology centers identified by "National Newborn Screening Program" (NNSP) who were born in 2015 and followed for 6 years...
March 28, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38546915/effects-of-several-auxiliary-acceptors-and-anchoring-groups-on-charge-transfer-and-photophysical-properties-of-d-a-%C3%AF-a-type-dsscs-a-dft-study
#28
JOURNAL ARTICLE
Mingjianshuo Gong, Lingpeng Zeng, Wenbo Wang, Xuanchen Dong, Zhenshuo Yu, Songhao Wang, Yi Yang
In this paper, we performed theoretical studies on the twelve D-A-π-A type organic dyes (G-1 ~ G-3, M-1 ~ M-3, J-1 ~ J-3, and S-1 ~ S-3) with 9-phenylcarbazole as the electron donor in anticipation of the application of these dyes in dye-sensitized solar cells (DSSCs). DFT and TD-DFT methods are applied to investigate in detail the molecular geometries, frontier molecular orbitals (FMOs), absorption spectra, charge density difference (CDD), and transition density matrix (TDM) of several dyes...
March 28, 2024: Journal of Fluorescence
https://read.qxmd.com/read/38546874/acetylation-of-c-myc-at-lysine-148-protects-neurons-after-ischemia
#29
JOURNAL ARTICLE
V V Guzenko, S S Bachurin, V A Dzreyan, A M Khaitin, Y N Kalyuzhnaya, S V Demyanenko
This study focuses on understanding the role of c-Myc, a cancer-associated transcription factor, in the penumbra following ischemic stroke. While its involvement in cell death and survival is recognized, its post-translational modifications, particularly acetylation, remain understudied in ischemia models. Investigating these modifications could have significant clinical implications for controlling c-Myc activity in the central nervous system. Although previous studies on c-Myc acetylation have been limited to non-neuronal cells, our research examines its expression in perifocal cells during stroke recovery to explore regulatory mechanisms via acetylation...
March 28, 2024: Neuromolecular Medicine
https://read.qxmd.com/read/38546871/assigning-a-social-status-from-face-adornments-an-fmri-study
#30
JOURNAL ARTICLE
M Salagnon, F d'Errico, S Rigaud, E Mellet
For at least 150,000 years, the human body has been culturally modified by the wearing of personal ornaments and probably by painting with red pigment. The present study used functional magnetic resonance imaging to explore the brain networks involved in attributing social status from face decorations. Results showed the fusiform gyrus, orbitofrontal cortex, and salience network were involved in social encoding, categorization, and evaluation. The hippocampus and parahippocampus were activated due to the memory and associative skills required for the task, while the inferior frontal gyrus likely interpreted face ornaments as symbols...
March 28, 2024: Brain Structure & Function
https://read.qxmd.com/read/38546870/comparative-mri-analysis-of-the-forebrain-of-three-sauropsida-models
#31
JOURNAL ARTICLE
S Jiménez, I Santos-Álvarez, E Fernández-Valle, D Castejón, P Villa-Valverde, C Rojo-Salvador, P Pérez-Llorens, M J Ruiz-Fernández, S Ariza-Pastrana, R Martín-Orti, Juncal González-Soriano, Nerea Moreno
The study of the brain by magnetic resonance imaging (MRI) allows to obtain detailed anatomical images, useful to describe specific encephalic structures and to analyze possible variabilities. It is widely used in clinical practice and is becoming increasingly used in veterinary medicine, even in exotic animals; however, despite its potential, its use in comparative neuroanatomy studies is still incipient. It is a technology that in recent years has significantly improved anatomical resolution, together with the fact that it is non-invasive and allows for systematic comparative analysis...
March 28, 2024: Brain Structure & Function
https://read.qxmd.com/read/38546839/c-h-n-h-and-o-h-bond-activations-to-prepare-phosphorescent-hydride-iridium-iii-phosphine-emitters-with-photocatalytic-achievement-in-c-c-coupling-reactions
#32
JOURNAL ARTICLE
María Benítez, María L Buil, Miguel A Esteruelas, Ana M López, Cristina Martín-Escura, Enrique Oñate
Complex IrH5 (Pi Pr3 )2 ( 1 ) activates two different σ-bonds of 3-phenoxy-1-phenylisoquinoline, 2-(1 H -benzimidazol-2-yl)-6-phenylpyridine, 2-(1 H -indol-2-yl)-6-phenylpyridine, 2-(2-hydroxyphenyl)-6-phenylpyridine, N -(2-hydroxyphenyl)- N '-phenylimidazolylidene, and 1,3-di(2-pyridyl)-4,6-dimethylbenzene to give IrH{κ3 - C,N,C -[C6 H4 -isoqui-O-C6 H4 ]}(Pi Pr3 )2 ( 2 ), IrH{κ3 - N,N,C -[NBzim-py-C6 H4 ]}(Pi Pr3 )2 ( 3 ), IrH{κ3 - N,N,C -[Ind-py-C6 H4 ]}(Pi Pr3 )2 ( 4 ), IrH{κ3 - C,N,O -[C6 H4 -py-C6 H4 O]}(Pi Pr3 )2 ( 5 ), IrH{κ3 - C,C,O -[C6 H4 -Im-C6 H4 O]}(Pi Pr3 )2 ( 6 ), and IrH{κ3 - N,C,C -[py-C6 HMe2 -C5 H3 N]}(Pi Pr3 )2 ( 7 ), respectively...
March 28, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38546823/drug-polymer-nanodroplet-formation-and-morphology-drive-solubility-enhancement-of-gdc-0810
#33
JOURNAL ARTICLE
Kaylee E Barr, Monica L Ohnsorg, Lucy Liberman, Louis G Corcoran, Apoorva Sarode, Karthik Nagapudi, Christina R Feder, Frank S Bates, Theresa M Reineke
Nanodroplet formation is important to achieve supersaturation of active pharmaceutical ingredients (APIs) in an amorphous solid dispersion. The aim of the current study was to explore how polymer composition, architecture, molar mass, and surfactant concentration affect polymer-drug nanodroplet morphology with the breast cancer API, GDC-0810. The impact of nanodroplet size and morphology on dissolution efficacy and drug loading capacity was explored using polarized light microscopy, dynamic light scattering, and cryogenic transmission electron microscopy...
March 28, 2024: Bioconjugate Chemistry
https://read.qxmd.com/read/38546822/transcutaneous-vagal-nerve-stimulation-for-treating-gastrointestinal-symptoms-in-individuals-with-diabetes-a-randomised-double-blind-sham-controlled-multicentre-trial
#34
JOURNAL ARTICLE
Ditte S Kornum, Davide Bertoli, Huda Kufaishi, Anne-Marie Wegeberg, Tina Okdahl, Esben B Mark, Katrine L Høyer, Jens B Frøkjær, Birgitte Brock, Klaus Krogh, Christian S Hansen, Filip K Knop, Christina Brock, Asbjørn M Drewes
AIMS/HYPOTHESIS: Diabetic gastroenteropathy frequently causes debilitating gastrointestinal symptoms. Previous uncontrolled studies have shown that transcutaneous vagal nerve stimulation (tVNS) may improve gastrointestinal symptoms. To investigate the effect of cervical tVNS in individuals with diabetes suffering from autonomic neuropathy and gastrointestinal symptoms, we conducted a randomised, sham-controlled, double-blind (participants and investigators were blinded to the allocated treatment) study...
March 28, 2024: Diabetologia
https://read.qxmd.com/read/38546820/computational-investigation-of-the-covalent-inhibition-mechanism-of-bruton-s-tyrosine-kinase-by-ibrutinib
#35
JOURNAL ARTICLE
Angela M Barragan, Kyle Ghaby, Matthew P Pond, Benoît Roux
Covalent inhibitors represent a promising class of therapeutic compounds. Nonetheless, rationally designing covalent inhibitors to achieve a right balance between selectivity and reactivity remains extremely challenging. To better understand the covalent binding mechanism, a computational study is carried out using the irreversible covalent inhibitor of Bruton tyrosine kinase (BTK) ibrutinib as an example. A multi-μs classical molecular dynamics trajectory of the unlinked inhibitor is generated to explore the fluctuations of the compound associated with the kinase binding pocket...
March 28, 2024: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/38546811/structure-based-multitargeted-docking-screening-pharmacokinetics-dft-and-dynamics-simulation-studies-reveal-mitoglitazone-as-a-potent-inhibitor-of-cellular-survival-and-stress-response-proteins-of-lung-cancer
#36
JOURNAL ARTICLE
Abdulkarim S Binshaya, Omar Saad Alkahtani, Fahad M Aldakheel, Ahmed Hjazi, Hassan H Almasoudi
Lung cancer is a disease in which lung cells grow abnormally and uncontrollably, and the cause of it is direct smoking, secondhand smoke, radon, asbestos, and certain chemicals. The worldwide leading cause of death is lung cancer, which is responsible for more than 1.8 million deaths yearly and is expected to rise to 2.2 million by 2030. The most common type of lung cancer is non-small cell lung cancer (NSCLC), which accounts for about 80% and small cell lung cancer (SCLC), which is more aggressive than NSCLC and is often diagnosed later and accounts for 20% of cases...
March 28, 2024: Medical Oncology
https://read.qxmd.com/read/38546802/trends-in-burdens-of-disease-by-transmission-source-usa-2005-2020-and-hazard-identification-for-foods-focus-on-milkborne-disease
#37
JOURNAL ARTICLE
Michele M Stephenson, Margaret E Coleman, Nicholas A Azzolina
BACKGROUND: Robust solutions to global, national, and regional burdens of communicable and non-communicable diseases, particularly related to diet, demand interdisciplinary or transdisciplinary collaborations to effectively inform risk analysis and policy decisions. OBJECTIVE: U.S. outbreak data for 2005-2020 from all transmission sources were analyzed for trends in the burden of infectious disease and foodborne outbreaks. METHODS: Outbreak data from 58 Microsoft Access® data tables were structured using systematic queries and pivot tables for analysis by transmission source, pathogen, and date...
March 28, 2024: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/38546800/aso-visual-abstract-high-community-level-social-vulnerability-is-associated-with-worse-recurrence-free-survival-following-resection-of-extremity-and-truncal-soft-tissue-sarcoma
#38
JOURNAL ARTICLE
Raymond S Traweek, Heather Lyu, Russell G Witt, Rebecca A Snyder, Elise F Nassif, David D Krijgh, Jeffrey M Smith, Gordon S Tilney, Chun Feng, Yi-Ju Chiang, Keila E Torres, Margaret J Roubaud, Christopher P Scally, Kelly K Hunt, Emily Z Keung, Alexander F Mericli, Christina L Roland
No abstract text is available yet for this article.
March 28, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38546785/patient-perceptions-of-barriers-to-attending-annual-diabetes-review-and-foot-assessment-in-general-practice-a-qualitative-study
#39
JOURNAL ARTICLE
William Ju, Ibrahim S Al-Busaidi, Helen Lunt, Ben Hudson
Introduction Regular diabetic foot checks, at least annually, are important for early identification of risk factors and prevention of ulceration and amputation. To ensure this, most general practices in Aotearoa New Zealand (NZ) offer free annual diabetes reviews (ADRs) which include a comprehensive foot evaluation. However, attendance rates at these ADRs are low. Aim To explore patients' perspectives on the barriers to attending ADRs and foot checks. Methods Semi-structured interviews with people with type 2 diabetes who were overdue their ADR (n  = 13; 7 women, 6 Māori) from two urban practices were conducted...
March 2024: Journal of Primary Health Care
https://read.qxmd.com/read/38546766/-i-think-we-just-do-it-once-and-leave-it-%C3%A2-the-collection-and-utility-of-family-health-history-in-general-practice-in-aotearoa-new-zealand-a-qualitative-study
#40
JOURNAL ARTICLE
R Jefferies, P Wilcox, K Paringatai, M Stubbe, R Grainger, A Dowell, S K Filoche
Introduction The value of family health history as a means to understanding health risk has been long known. Its value in a precision medicine context is also now becoming apparent. General practitioners (GPs) are considered to play a key role in the collection, and investigation, of family health history, but it remains widely reported as being both poorly and infrequently undertaken. Little is known about this practice in Aotearoa New Zealand (NZ). Aim This study aimed to explore current practices in relation to the ascertainment of family health history, with a view towards precision medicine...
March 2024: Journal of Primary Health Care
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