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https://www.readbyqxmd.com/read/28239984/cost-effectiveness-of-extended-release-naltrexone-to-prevent-relapse-among-criminal-justice-involved-persons-with-a-history-of-opioid-use-disorder
#1
Sean M Murphy, Daniel Polsky, Joshua D Lee, Peter D Friedmann, Timothy W Kinlock, Edward V Nunes, Richard J Bonnie, Michael Gordon, Donna T Chen, Tamara Y Boney, Charles P O'Brien
BACKGROUND/AIMS: Criminal-justice-involved persons are highly susceptible to opioid relapse and overdose-related deaths. In a recent randomized trial, we demonstrated the effectiveness of extended release naltrexone (XR-NTX; Vivitrol®) in preventing opioid relapse among criminal-justice-involved U.S. adults with a history of opioid use disorder. The cost of XR-NTX may be a significant barrier to adoption. Thus, it is important to account for improved quality of life, and downstream cost-offsets...
February 26, 2017: Addiction
https://www.readbyqxmd.com/read/28239971/characterization-of-n-methylated-amino-acids-by-gc-ms-after-ethyl-chloroformate-derivatization
#2
B Sudarshana Reddy, V Naresh Chary, P Pavankumar, S Prabhakar
Methylation is an essential metabolic process in the biological systems, and it is significant for several biological reactions in living organisms. Methylated compounds are known to be involved in most of the bodily functions, and some of them serve as biomarkers. Theoretically, all α-amino acids can be methylated, and it is possible to encounter them in most animal/plant samples. But the analytical data, especially the mass spectral data, are available only for a few of the methylated amino acids. Thus, it is essential to generate mass spectral data and to develop mass spectrometry methods for the identification of all possible methylated amino acids for future metabolomic studies...
August 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28239964/training-in-metabolomics-research-ii-processing-and-statistical-analysis-of-metabolomics-data-metabolite-identification-pathway-analysis-applications-of-metabolomics-and-its-future
#3
S Barnes, H P Benton, K Casazza, S J Cooper, X Cui, X Du, J Engler, J H Kabarowski, S Li, W Pathmasiri, J K Prasain, M B Renfrow, H K Tiwari
Metabolomics is perhaps the most challenging of the -omics fields, given the complexity of an organism's metabolome and the rapid rate at which it changes. When one sets out to study metabolism there are numerous dynamic variables that can influence metabolism that must be considered. Recognizing the experimental challenges confronting researchers who undertake metabolism studies, workshops like the one at University of Alabama at Birmingham have been established to offer instructional guidance. A summary of the UAB course training materials is being published as a two-part Special Feature Tutorial...
August 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28239963/characterization-of-complex-heterogeneous-lipid-a-samples-using-hplc-ms-ms-technique-ii-structural-elucidation-of-non-phosphorylated-lipid-a-by-negative-ion-mode-tandem-mass-spectrometry
#4
Viktor Sándor, Anikó Kilár, Ferenc Kilár, Béla Kocsis, Ágnes Dörnyei
Non-phosphorylated lipid A species confer reduced inflammatory potential for the bacteria. Knowledge on their chemical structure and presence in bacterial pathogens may contribute to the understanding of bacterial resistance and activation of the host innate immune system. In this study, we report the fragmentation pathways of negatively charged, non-phosphorylated lipid A species under low-energy collision-induced dissociation conditions of an electrospray ionization quadrupole time-of-flight instrument. Charge-promoted consecutive and competitive eliminations of the acyl chains and cross-ring cleavages of the sugar residues were observed...
August 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28239937/smoking-does-not-influence-disability-accumulation-in-primary-progressive-multiple-sclerosis
#5
O Javizian, L M Metz, S Deighton, M W Koch
BACKGROUND AND PURPOSE: The modifiable risk factor cigarette smoking has been associated with an increased risk of developing multiple sclerosis (MS) and with disease activity in relapsing-remitting MS. However, less is known about the effect of smoking on disease progression in progressive MS. Here the association between cigarette smoking and disability accumulation in primary progressive MS (PPMS) is investigated. METHODS: Kaplan-Meier survival analyses and Cox proportional hazard modelling were used to investigate the influence of cigarette smoking on the risk of reaching Expanded Disability Status Scale (EDSS) 4 and 6 as well as the time from EDSS 4 to 6 in patients with PPMS...
February 26, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28239935/isolation-and-characterization-of-an-atypical-siberian-sturgeon-herpesvirus-strain-in-russia-novel-north-american-acipenserid-herpesvirus-2-strain-in-europe
#6
A Doszpoly, I M Kalabekov, R Breyta, I S Shchelkunov
Siberian sturgeon herpesvirus (SbSHV) was isolated in Russia for the first time in 2006. Nine SbSHV isolates were recovered from different fish hatcheries producing the same cytopathic effect in cell cultures, the same clinical signs and mortality kinetics in virus-infected fish and the same virus neutralization pattern and shared identical nucleotide sequences. In 2011, a new isolate was recovered from juvenile sturgeon, which caused completely different cytopathic effect. That isolate was not readily neutralized by Siberian sturgeon hyperimmune antisera, and its DNA was not recognized by the routine PCR developed for SbSHV detection...
February 27, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28239901/molecular-prevalence-of-merkel-cell-polyomavirus-in-nonmelanoma-skin-cancer-in-a-brazilian-population
#7
T R Bellott, C F Baez, S G Almeida, M T Venceslau, M G Zalis, M A Guimarães, M C Rochael, F B Luz, R B Varella, J R Almeida
BACKGROUND: Merkel cell polyomavirus (MCPyV), a newly described oncogenic virus, has been found in association with tumours other than Merkel cell carcinoma (MCC). As yet, little is known about the involvement or influence of MCPyV on the development of these tumours and its prevalence in various populations. AIM: To assess the prevalence of MCPyV DNA in cases of nonmelanoma skin cancer (NMSC). METHODS: The prevalence of MCPyV DNA was assessed in 96 cases of NMSC in a Brazilian population comprising 76 subjects, and these results were correlated with epidemiological and demographical data...
February 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28239900/the-influence-of-the-size-age-and-sex-on-the-computed-tomographic-measured-size-of-the-pituitary-gland-in-normal-horses
#8
C P Crijns, H J Van Bree, B J G Broeckx, S Schauvliege, G Van Loon, A Martens, K Vanderperren, W B Dingemanse, I M Gielen
The objective of this study was to examine the influence of the size, age and sex of the horse on the size of the pituitary gland and determine the possibility of using the pituitary gland height-to-brain area ratio (P:B ratio) to allow comparison of different sized and aged horses. Thirty-two horses without pituitary pars inter-media dysfunction that underwent a contrast-enhanced computed tomographic (CT) examination were included in a cross-sectional study. On the CT images, the pituitary gland height was measured and the P:B ratio was calculated...
February 27, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/28239886/fibrocartilaginous-mesenchymoma-of-bone-a-single-institution-experience-with-molecular-investigations-and-a-review-of-the-literature
#9
M Gambarotti, A Righi, D Vanel, S Cocchi, S Benini, F M Elli, G Mantovani, P Ruggieri, S Boriani, D Donati, M Sbaraglia, A P Dei Tos, P Picci
AIMS: Fibrocartilaginous mesenchymoma is a rare intraosseous lesion with a total of 25 cases described in the literature. This study describes the clinical, radiological, and histological features of eight new cases of fibrocartilaginous mesenchymoma collected at a single institution between 1982 and 2016. The presence of GNAS and IDH1/2 mutations and MDM2 amplification was explored to evaluate possible links between fibrocartilaginous mesenchymoma, fibrous dysplasia, dedifferentiated chondrosarcoma, and low-grade osteosarcoma...
February 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28239874/habitat-segregation-and-cryptic-adaptation-of-species-of-periophthalmus-gobioidei-gobiidae
#10
G Polgar, S Zaccara, M Babbucci, F Fonzi, C M Antognazza, N Ishak, Z Sulaiman, G Crosa
A study was conducted on the habitat distribution of four sympatric species of Periophthalmus (the silver-lined mudskipper Periophthalmus argentilineatus, the slender mudskipper Periophthalmus gracilis, the kalolo mudskipper Periophthalmus kalolo and the Malacca mudskipper Periophthalmus malaccensis) from northern Sulawesi. Molecular phylogenetic reconstructions based on one mtDNA marker (16S) were used to validate the morphological taxa, identifying five molecular clades. Periophthalmus argentilineatus includes two molecular species, which are named Periophthalmus argentilineatus clades F and K...
February 27, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28239867/inpatient-cost-analysis-for-treatment-of-myasthenia-gravis
#11
Jacklyn O Omorodion, Jesse M Pines, Henry J Kaminski
INTRODUCTION: We explored trends in U.S. inpatient costs of care over a 10-year period. METHODS: We compared myasthenia gravis (MG) to multiple sclerosis (MS) and overall U.S. hospital admissions using the Agency for Healthcare Research and Quality Nationwide Inpatient Sample database for 2003-2013. RESULTS: Total costs of MG inpatient care rose 13-fold from 2003-2013. This was accounted for by a >6-fold increase in discharges and a >2-fold increase in cost per discharge...
February 27, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28239863/roaming-behaviour-of-dogs-in-four-remote-aboriginal-communities-in-the-northern-territory-australia-preliminary-investigations
#12
S Molloy, A Burleigh, S Dürr, M P Ward
OBJECTIVE: To estimate the home range (HR) and investigate the potential predictors for roaming of 58 dogs in four Aboriginal communities in the Northern Territory. DESIGN: Prospective study. PROCEDURE: Global positioning system (GPS) collars were attached to the dogs for 1-4 days, recording location fixes every 1-3 min. Utilisation distributions (UDs) and extended (95% isopleth) and core (50% isopleth) HRs of dogs were determined. Potential predictors of roaming were assessed...
March 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28239861/glucocorticoid-deficient-hypoadrenocorticism-secondary-to-intravascular-lymphoma-in-the-adrenal-glands-of-a-dog
#13
M E Buckley, P S Chapman, A Walsh
CASE REPORT: A 2-year-old neutered male German Shepherd dog was presented with weakness, poor appetite and weight loss. Glucocorticoid-deficient hypoadrenocorticism was diagnosed with undetectable pre- and post-ACTH cortisol concentrations but normal sodium and potassium concentrations. Despite appropriate supplementation with glucocorticoids, the patient's weakness progressed and neurological deficits developed. The patient was euthanased. Histopathological analysis of multiple organs, including the adrenal glands, showed an accumulation of neoplastic lymphocytes within blood vessels, consistent with a diagnosis of intravascular lymphoma...
March 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28239826/observational-multicentric-survey-on-carpal-tunnel-syndrome-demographic-and-clinical-data-from-34-italian-centers
#14
R Luchetti, S Tognon, M Cacciavillani, S Ronco, N Buzzelli, G Lanni
OBJECTIVE: To evaluate the current management of carpal tunnel syndrome (CTS) at a national level. PATIENTS AND METHODS: A multicentric observational study was conducted in 34 Italian centers by specialists participating in the Management of Peripheral Neuropathies Study Group on 377 patients (age, mean±SD 56±14.4 years, 73.2% females) with CTS. The characteristics of the disease and its management were recorded at baseline and during a 2-month follow-up using a standardized clinical record and assessed with validated clinical tests...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239821/analysis-of-circulating-long-non-coding-rna-uca1-as-potential-biomarkers-for-diagnosis-and-prognosis-of-osteosarcoma
#15
J-J Wen, Y-D Ma, G-S Yang, G-M Wang
OBJECTIVE: The aim of this investigation was to examine the potential usefulness of long non-coding RNA UCA1 (UCA1) as a biomarker for diagnosis and prognosis in osteosarcoma. PATIENTS AND METHODS: The expression level of UCA1 was determined using TaqMan real-time PCR in human osteosarcoma tissues and patients' sera. Next, we investigated to clarify the relationship of UCA1 with clinicopathological features. The receiver operating characteristic (ROC) curve was performed to estimate the diagnostic value of UCA1...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239806/mechanism-of-action-of-kiaa1456-gene-on-the-proliferation-and-apoptosis-of-alveolar-epithelial-cells
#16
S-L Wang, J-A Huang, X-Q Liu
OBJECTIVE: To explore the mechanism by which KIAA1456 acts on alveolar epithelial cells through lentiviral transfection. MATERIALS AND METHODS: After constructing a KIAA1456 gene vector, 293T cells were co-transfected with lentiviral vectors and after incubation cells were examined by fluorescence microscopy. CCL-149 cells were transfected with LV-KIAA1456 and were examined by fluorescence microscopy. The proliferation capacity of transfected CCL-149 cells was evaluated using flow cytometry...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239802/anesthetic-management-of-patients-with-dilated-cardiomyopathy-for-noncardiac-surgery
#17
C-Q Chen, X Wang, J Zhang, S-M Zhu
Anesthetic management of patients with dilated cardiomyopathy (DCM) is a challenge to the anesthesiologist, due to poor left systolic function, ventricular enlargement, risk of malignant arrhythmias and sudden cardiac death. Therefore, preoperative assessment and appropriate anesthetic management are important in patients with DCM. This review describes the preoperative evaluation and anesthesia considerations of patients with DCM undergoing non-cardiac surgery. Patient pathophysiology and clinical status, such as ventricular function, degree of myocardial fibrosis, resting heart rate and high-sensitivity C-reactive protein can affect survival rates...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239799/the-consistency-of-myocardial-strain-derived-from-heart-deformation-analysis
#18
Eric J Keller, Shanna Fang, Kai Lin, Benjamin H Freed, Peter M Smith, Bruce S Spottiswoode, Rachel Davids, Maria Carr, Marie-Pierre Jolly, Michael Markl, James C Carr, Jeremy D Collins
The purpose of this study was to assess the consistency of semi-automated myocardial strain analysis by prototype software across field strengths, temporal resolutions, and examinations. 35 volunteers (48 ± 13 years; 20% women) and 25 patients (54 ± 12 years; 44% women) without significant cardiac dysfunction underwent cine cardiac magnetic resonance imaging (CMR) at 1.5 T with a temporal resolution of 39.2 msec. 34 subjects also underwent imaging at 3.0 T; 16 had repeat examinations within 14 days; and 9 underwent CMR with temporal resolutions of 12...
February 26, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28239795/antiproliferative-activity-of-a-new-nitrosyl-iron-complex-with-cysteamine-in-human-tumor-cells-in-vitro
#19
O S Zhukova, Z S Smirnova, I O Chikileva, M V Kiselevskii
We studied cytotoxic activity of a new NO-releasing tetranitrosyl binuclear iron complex with cysteamine (CysAm) for human tumor cells, the relationship between the expression of O6-methylguanine-DNA methyltransferase (MGMT) and cell sensitivity to CysAm, and apoptosis-inducing capacity of this preparation. It was found that histogenetically different cell lines are characterized by different sensitivity to CysAm, and this parameter correlated with the basal level of MGMT. CysAm induced apoptosis via activation of caspases 3 and 7...
February 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28239794/cystatin-c-as-a-marker-of-progressing-cardiovascular-events-during-coronary-heart-disease
#20
M M Gevorgyan, N P Voronina, N V Goncharova, T V Kozaruk, G S Russkikh, L A Bogdanova, T A Korolenko
The role of cystatin C, an inhibitor of cysteine proteases, as an alternative and potent predictor of acute cardiovascular events in coronary heart disease (CHD) patients was examined and compared to that of other markers of cardiorenal abnormalities. The patients with CHD demonstrated elevated serum cystatin C, especially in cases with serious risk of cardiovascular complications. In comparison with other indicators of cardiorenal dysfunction, cystatin C can be viewed as an alternative predictor of cardiovascular complications, although its sensitivity is inferior to that of high-sensitivity C-reactive protein and natriuretic peptide...
February 27, 2017: Bulletin of Experimental Biology and Medicine
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