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Complex sleep apnea syndrome

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https://www.readbyqxmd.com/read/27886849/prevalence-and-burden-of-comorbidities-in-chronic-obstructive-pulmonary-disease
#1
REVIEW
Alexandru Corlateanu, Serghei Covantev, Alexander G Mathioudakis, Victor Botnaru, Nikolaos Siafakas
The classical definition of Chronic Obstructive Pulmonary Disease (COPD) as a lung condition characterized by irreversible airway obstruction is outdated. The systemic involvement in patients with COPD, as well as the interactions between COPD and its comorbidities, justify the description of chronic systemic inflammatory syndrome. The pathogenesis of COPD is closely linked with aging, as well as with cardiovascular, endocrine, musculoskeletal, renal, and gastrointestinal pathologies, decreasing the quality of life of patients with COPD and, furthermore, complicating the management of the disease...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27829262/-upper-airway-stimulation-in-osa
#2
B Bender
Anatomical basis of obstructive sleep apnea (OSA) is the collapse of the pharynx during sleep. It is considered as a result of complex interactions of structural and neuromuscular factors. Depth of sleep and body position have modulating effects. Although different areas of obstruction were identified, studies show that the sleep-mediated obstruction frequently occurs in the base of tongue area.Continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnea syndrome (OSAS) since more than 30 years...
November 2016: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/27789174/-pediatric-obstructive-sleep-apnea-syndrome-treatment-strategy
#3
J Cohen-Lévy, J Potenza, V Couloigner
Pediatric obstructive sleep apnea syndrome (OSAS) has a multifactorial origin. For the child with no dysmorphic disorders or comorbidities, its main etiology is pharyngeal soft tissue hypertrophy, a dimensional reduction of the facial skeletal frame restricting the airway, an anomaly of muscular tone, or a combination of these factors. Consequently, proper diagnosis and treatment planning for these children can require several medical specialties, according to the complexity, severity, and persistence of OSAS: ear-nose-throat specialists (ENT), pneumologists/allergologists, dentofacial orthopedists/orthodontists, and physical therapists/speech therapists...
October 24, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27769628/-obesity-and-obstructive-sleep-apnea-in-children
#4
A Amaddeo, L de Sanctis, J Olmo Arroyo, J-P Giordanella, P-J Monteyrol, B Fauroux
Obesity, along with hypertrophy of the adenoids and the tonsils, represents one of the major risk factors for obstructive sleep apnea (OSA) in children. Obesity is associated with an increase in the prevalence and the severity of OSA and is a major factor in the persistence and aggravation of OSA over time. Neurocognitive dysfunction and abnormal behavior are the most important and frequent end-organ morbidities associated with OSA in children. Other deleterious consequences such as cardiovascular stress and metabolic syndrome are less common in children than in adults with OSA...
October 18, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27754829/potential-inflammatory-markers-in-obstructive-sleep-apnea-hypopnea-syndrome
#5
Dongmei Lu, Nanfang Li, Xiaoguang Yao, Ling Zhou
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a complex chronic inflammatory respiratory disease with multiple pathogenic factors and high morbidity and mortality. Serum levels of nuclear factor-κB (NF-κB), hypoxia-inducible factor-1 alpha (HIF-1α), and surfactant protein D (SPD) were investigated in OSAHS patients, to determine their clinical significance and correlation with the pathogenesis. Patients were classified into a mild and moderate OSAHS group (n = 25) and severe OSAHS group (n = 33). Twenty healthy patients served as a control group...
October 18, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27631230/assessment-of-regional-right-ventricular-systolic-function-in-patients-with-obstructive-sleep-apnea-syndrome-using-velocity-vector-imaging
#6
Junfang Li, Zhibing Wang, Yong Li, Yuanyuan Meng, Rong Li, Wugang Wang, Xiuxiu Fu
Obstructive sleep apnea syndrome (OSAS) is the most common type of sleep disorder which is associated with a series of cardiovascular disorders, including right ventricular (RV) dysfunction. However, it is difficult to assess the RV function systematically using a conventional echocardiography because RV has a complex geometrical shape. A case-control study was performed to assess the regional right ventricular potential dysfunction in patients with OSAS using velocity vector imaging (VVI) from March 2014 to October 2015...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27584711/sleep-disorders-in-machado-joseph-disease
#7
José Luiz Pedroso, Pedro Braga-Neto, Alberto R M Martinez, Carlos R Martins, Flávio M Rezende Filho, Manoel A Sobreira-Neto, Lucila B F Prado, Gilmar F do Prado, Marcondes C França, Orlando G P Barsottini
PURPOSE OF REVIEW: This article provides a description on clinical features and pathophysiology of the main sleep disorders observed in Machado-Joseph disease (MJD). RECENT FINDINGS: Pathological studies have clearly demonstrated that degenerative process in MJD is widespread in the nervous system, and not restricted to the cerebellum. Nonmotor manifestations are frequent and may include pain, cramps, dysautonomia, cognitive deficits, psychiatric manifestations, olfactory deficits, fatigue, nutritional issues, and sleep disorders...
November 2016: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/27508563/-op-8b-05-coagulation-system-activity-in-patients-with-obstructive-sleep-apnoea-syndrome-and-arterial-hypertension
#8
T Bugaev, N V Ageeva, A B Dobrovolskiy, A Y Litvin, I E Chazova
OBJECTIVE: This study aimed to determine association obstructive sleep apnea (OSA) with increased coagulability and reveal possible effects of constant positive airway pressure (CPAP). DESIGN AND METHOD: We included 77 patients with arterial hypertension (duration of AH = 13.8 ± 3.7 years), middle-aged (45.9 ± 10.5 years). 41 (53.2%) of them had severe OSA (AHI = 59.6 ± 26). OSA was diagnosed by means of cardiorespiratory monitoring. In patients with severe OSA blood samples (D-dimer, viscosity of blood, erythrocyte aggregation) were taken at baseline and after 3-4 nights of effective CPAP therapy (AHI < 5)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27489385/zolpidem-induced-sleep-related-eating-and-complex-behaviors-in-a-patient-with-obstructive-sleep-apnea-and-restless-legs-syndrome
#9
Young-Min Park, Hyun-Woo Shin
Zolpidem-induced sleep-related complex behaviors (SRCB) with anterograde amnesia have been reported. We describe herein a case in which the development of zolpidem-induced sleep-related eating disorder (SRED) and SRCB was strongly suspected. A 71-year-old Korean male was admitted to the Department of Psychiatry due to his repetitive SRED and SRCB with anterograde amnesia, which he reported as having occurred since taking zolpidem. The patient also had restless legs syndrome (RLS) and obstructive sleep apnea (OSA)...
August 31, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27487240/mr-image-analytics-to-characterize-the-upper-airway-structure-in-obese-children-with-obstructive-sleep-apnea-syndrome
#10
Yubing Tong, Jayaram K Udupa, Sanghun Sin, Zhengbing Liu, E Paul Wileyto, Drew A Torigian, Raanan Arens
PURPOSE: Quantitative image analysis in previous research in obstructive sleep apnea syndrome (OSAS) has focused on the upper airway or several objects in its immediate vicinity and measures of object size. In this paper, we take a more general approach of considering all major objects in the upper airway region and measures pertaining to their individual morphological properties, their tissue characteristics revealed by image intensities, and the 3D architecture of the object assembly...
2016: PloS One
https://www.readbyqxmd.com/read/27397091/polymorphism-in-endothelin-1-gene-an-overview
#11
Musa A Ahmed, Abir Rghigh
Endothelin-1, (ET-1, EDN1) is endogenous polypeptide demonstrates dominant vasoconstriction activity and mitogenic effect, on the heart it has positive inotropic and chronotropic properties, stimulates the sympathetic and the renin-angiotensin-aldosterone systems and modify homeostasis. The human ET-1 gene which consists of 6836 nucleotides located on chromosome 6p23-p24 produces Pre-pro-ET-1, which consequently cleaved to big-ET-1. The mature 21-amino acid ET-1 is generated by subsequent enzymatic cleavage of the big-ET-1...
June 30, 2016: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/27370206/idiopathic-intracranial-hypertension-eliminated-by-counterclockwise-maxillomandibular-advancement-a-case-report
#12
Deborah Wardly, Larry M Wolford, Venkat Veerappan
INTRODUCTION: Obstructive sleep apnea (OSA) is a secondary cause of intracranial hypertension (IH). Decreased jugular venous drainage has been seen in patients with idiopathic IH. CLINICAL PRESENTATION: A complex case of a 48-year-old female whose idiopathic IH was put into remission after counterclockwise maxillomandibular advancement (CC-MMA), despite persistence of her OSA. CONCLUSION: This case highlights the relationship between OSA and IH and points to the significant morbidity that can result from mild OSA and from what are considered borderline intracranial pressures...
July 1, 2016: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/27339289/physiological-adaptation-after-a-12-week-physical-activity-program-for-patients-with-prader-willi-syndrome-two-case-reports
#13
Alexandre Slowetzky Amaro, Maria Cristina Triguero Veloz Teixeira, Maria Luiza Guedes de Mesquita, Graciele Massoli Rodrigues, Daniela Andrea Rubin, Luiz Renato Rodrigues Carreiro
BACKGROUND: Physical activity programs are a powerful tool against several diseases including obesity and their comorbidities. Prader-Willi syndrome is the most common genetic disease associated with obesity, and brings with it behavioral and emotional problems that need complex management. Research into the effect of physical activity programs on Prader-Willi syndrome is limited and it is frequently argued that if a physical activity program is too complex, the participants are more likely to drop out...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27321089/-obstructive-sleep-apnea-syndrome-and-cognition-a-review
#14
REVIEW
Agnès Daurat, Majdouline Sarhane, Michel Tiberge
Obstructive sleep apnea syndrome (OSAS) is a sleep-related breathing disorder characterized by repetitive episodes of airflow cessation, resulting in brief arousals and intermittent hypoxemia. OSAS is associated with a number of adverse health consequences, and cognitive difficulties. The overall pattern of cognitive impairment in OSAS is complex, and research in this field is mixed. On balance, OSAS have negative effects on cognition, most likely in the domain of attention/vigilance, verbal and visual delayed long-term memory, and executive functions...
June 2016: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/27190276/intermittent-hypoxia-training-protects-cerebrovascular-function-in-alzheimer-s-disease
#15
Eugenia B Manukhina, H Fred Downey, Xiangrong Shi, Robert T Mallet
Alzheimer's disease (AD) is a leading cause of death and disability among older adults. Modifiable vascular risk factors for AD (VRF) include obesity, hypertension, type 2 diabetes mellitus, sleep apnea, and metabolic syndrome. Here, interactions between cerebrovascular function and development of AD are reviewed, as are interventions to improve cerebral blood flow and reduce VRF. Atherosclerosis and small vessel cerebral disease impair metabolic regulation of cerebral blood flow and, along with microvascular rarefaction and altered trans-capillary exchange, create conditions favoring AD development...
June 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27152260/sleep-disorders-and-chronic-kidney-disease
#16
REVIEW
Stephanie C Maung, Ammar El Sara, Cherylle Chapman, Danielle Cohen, Daniel Cukor
Sleep disorders have a profound and well-documented impact on overall health and quality of life in the general population. In patients with chronic disease, sleep disorders are more prevalent, with an additional morbidity and mortality burden. The complex and dynamic relationship between sleep disorders and chronic kidney disease (CKD) remain relatively little investigated. This article presents an overview of sleep disorders in patients with CKD, with emphasis on relevant pathophysiologic underpinnings and clinical presentations...
May 6, 2016: World Journal of Nephrology
https://www.readbyqxmd.com/read/27112685/autoimmune-sleep-disorders
#17
Michael H Silber
A number of autoantibodies, some paraneoplastic, are associated with sleep disorders. Morvan syndrome and limbic encephalitis, associated with voltage-gated potassium channel-complex antibodies, principally against CASPR2 and LGI1, can result in profound insomnia and rapid eye movement sleep behavior disorder (RBD). Patients with aquaporin-4 antibodies and neuromyelitis optica may develop narcolepsy in association with other evidence of hypothalamic dysfunction, sometimes as the initial presentation. Central sleep apnea and central neurogenic hypoventilation are found in patients with anti-N-methyl-d-aspartate receptor antibody encephalitis, and obstructive sleep apnea, stridor, and hypoventilation are prominent features of a novel tauopathy associated with IgLON5 antibodies...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27027516/comparison-of-heritability-estimation-and-linkage-analysis-for-multiple-traits-using-principal-component-analyses
#18
COMPARATIVE STUDY
Jingjing Liang, Brian E Cade, Heming Wang, Han Chen, Kevin J Gleason, Emma K Larkin, Richa Saxena, Xihong Lin, Susan Redline, Xiaofeng Zhu
A disease trait often can be characterized by multiple phenotypic measurements that can provide complementary information on disease etiology, physiology, or clinical manifestations. Given that multiple phenotypes may be correlated and reflect common underlying genetic mechanisms, the use of multivariate analysis of multiple traits may improve statistical power to detect genes and variants underlying complex traits. The literature, however, has been unclear as to the optimal approach for analyzing multiple correlated traits...
April 2016: Genetic Epidemiology
https://www.readbyqxmd.com/read/26997148/craniofacial-disorders-associated-with-airway-obstruction-in-the-neonate
#19
REVIEW
Christopher M Cielo, Fernando M Montalva, Jesse A Taylor
In infants with craniofacial disorders, upper airway obstruction is one of the primary causes for morbidity and mortality in the neonatal period. Infants with craniofacial disorders, including Pierre Robin sequence, are at high risk for obstructive sleep apnea syndrome. Because of the complexity of their care, these neonates are usually followed by a multidisciplinary team to ensure timely evaluation and optimal treatment. In addition to history and physical examination, clinical evaluation may include genetic testing, imaging, endoscopy, and polysomnography...
August 2016: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26943471/aberrant-insular-functional-network-integrity-in-patients-with-obstructive-sleep-apnea
#20
Bumhee Park, Jose A Palomares, Mary A Woo, Daniel W Kang, Paul M Macey, Frisca L Yan-Go, Ronald M Harper, Rajesh Kumar
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is accompanied by tissue injury to the insular cortices, areas that regulate autonomic pain, dyspnea, and mood, all of which are affected in the syndrome. Presumably, the dysregulation of insular-related functions are mediated by aberrant functional connections with other brain regions; however, the integrity of the functional connectivity (FC) to other sites is undescribed. Our aim was to examine resting-state FC of the insular cortices to other brain areas in OSA, relative to control subjects...
May 1, 2016: Sleep
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