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cryoablation for secondary liver tumor

Michael J Ryan, Jonathon Willatt, Bill S Majdalany, Ania Z Kielar, Suzanne Chong, Julie A Ruma, Amit Pandya
Ablative treatment methods have emerged as safe and effective therapies for patients with primary and secondary liver tumors who are not surgical candidates at the time of diagnosis. This article reviews the current literature and describes the techniques, complications and results for radiofrequency ablation, microwave ablation, cryoablation, and irreversible electroporation.
January 28, 2016: World Journal of Hepatology
Hyeon Yu, Charles T Burke
Tumor ablation is a minimally invasive technique used to deliver chemical, thermal, electrical, or ultrasonic damage to a specific focal tumor in an attempt to achieve substantial tumor destruction or complete eradication. As the technology continues to advance, several image-guided tumor ablations have emerged to effectively manage primary and secondary malignancies in the liver. Percutaneous chemical ablation is one of the oldest and most established techniques for treating small hepatocellular carcinomas...
June 2014: Seminars in Interventional Radiology
Alexandra H Fairchild, Servet Tatli, Ruth M Dunne, Paul B Shyn, Kemal Tuncali, Stuart G Silverman
PURPOSE: To assess safety and effectiveness of percutaneous image-guided cryoablation of hepatic tumors adjacent to the gallbladder. MATERIALS AND METHODS: Twenty-one cryoablation procedures were performed to treat 19 hepatic tumors (mean size, 2.7 cm; range, 1.0-5.0 cm) adjacent to the gallbladder in 17 patients (11 male; mean age, 59.2 y; range, 40-82 y) under computed tomography (n = 15) or magnetic resonance imaging (n = 6) guidance in a retrospective study...
September 2014: Journal of Vascular and Interventional Radiology: JVIR
Constantinos T Sofocleous, Panagiotis Sideras, Elena N Petre
Secondary liver malignancies are associated with significant mortality and morbidity if left untreated. Colorectal cancer is the most frequent origin of hepatic metastases. A multidisciplinary approach to the treatment of hepatic metastases includes medical, surgical, radiation and interventional oncology. The role of interventional oncology in the management of hepatic malignancies continues to evolve and applies to a large and continuous spectrum of metastatic disease, from the relatively small solitary metastasis to larger tumors and multifocal liver disease...
December 2013: Techniques in Vascular and Interventional Radiology
M N Islam, S A Azad, E Karim, S M Rahman, N A Khan
Hepatic malignancies are commonly faced clinical problem. Non surgical minimally invasive therapies are current treatment goal. Interventional radiologists are going forwards with such minimally invasive but effective therapies by transarterial chemoembolization, radiofrequency ablation, percutaneous ethanol injection, cryoablation, laser ablation and upcoming promising procedures like focused ultrasound & gene therapy. Response rates of transarterial chemoembolization for primary and most metastatic tumors are 60-80% with survival rates of 70% at 1 year, 40% at 3 years, and 10% at 5 years...
April 2012: Mymensingh Medical Journal: MMJ
James R McCarley, Michael C Soulen
The liver is a common site of both primary and secondary malignancy resulting in significant morbidity and mortality. Careful patient evaluation and triage allows for optimal utilization of all oncologic therapies, including radiation, systemic chemotherapy, surgery, transarterial therapies, and ablation. Although the role of interventional oncologists in the management of hepatic malignancies continues to evolve, the use of percutaneous ablation therapies has proven to be an effective and minimally invasive modality for treatment...
September 2010: Seminars in Interventional Radiology
Daniel Ansari, Roland Andersson
The liver is a common location of both primary and secondary malignancies. For unresectable liver cancer, many local ablative therapies have been developed. These include e.g., percutaneous ethanol injection (PEI), percutaneous acetic acid injection, radiofrequency ablation (RFA), cryoablation, microwave ablation, laser-induced thermotherapy, and high-intensity focused ultrasound. RFA has recently gained interest and is the most widely applied thermoablative technique. RFA allows more effective tumor control in fewer treatment sessions compared with PEI, but with a higher rate of complications...
March 14, 2012: World Journal of Gastroenterology: WJG
P Isfort, T Penzkofer, A H Mahnken
CLINICAL ISSUE: Primary and secondary liver tumors often limit patient outcome and only a minority of patients are eligible for potential curative surgery. Minimally invasive treatments, such as radiofrequency ablation (RFA), microwave ablation (MWA) and cryoablation are alternative treatment options in a curative and palliative setting. One major limitation of RFA and MWA is the limited size of tumor ablation. Furthermore during the procedure the ablation size can only be roughly estimated using RFA and MWA...
January 2012: Der Radiologe
R Hoffmann, H Rempp, S Clasen
CLINICAL ISSUE: The majority of patients with hepatic malignancies are not amenable to surgical resection. In some of these cases minimally invasive ablative therapies are a treatment option. STANDARD TREATMENT: Besides radiofrequency ablation, the most common ablative therapies are cryoablation, laser ablation and microwave ablation. TREATMENT INNOVATIONS: The classic fields of application of microwave ablation are the treatment of malignancies of the liver, kidneys and lungs...
January 2012: Der Radiologe
Akshat Saxena, Terence C Chua, Anik Sarkar, Francis Chu, Winston Liauw, Jing Zhao, David L Morris
BACKGROUND: Neuroendocrine neoplasms most commonly metastasize to the liver. Operative extirpation of neuroendocrine neoplasm hepatic metastases improves symptoms and seems to improve survival, but subsequent evidence is required. The current study evaluates the progression-free survival and overall survival of patients after resection (with or without ablation) of neuroendocrine neoplasm hepatic metastases. As a secondary endpoint, the prognostic factors associated with progression-free survival and overall survival were evaluated...
February 2011: Surgery
Stephan Clasen, Philippe L Pereira
Image-guided thermal ablation of liver tumors is a minimally invasive treatment option. Techniques used for thermal ablation are radiofrequency (RF) ablation, laser interstitial thermotherapy (LITT), microwave (MW) ablation, high-intensity focused ultrasound (HIFU), and cryoablation. Among these techniques RF ablation attained widespread consideration. Image guidance should ensure a precise ablation therapy leading to a complete coagulation of tumor tissue without injury to critical structures. Therefore, the modality of image guidance has an important impact on the safety and efficacy of percutaneous RF ablation...
February 2008: Journal of Magnetic Resonance Imaging: JMRI
Alessandro M Paganini, Adriana Rotundo, Luciana Barchetti, Emanuele Lezoche
Hepatic resection is the treatment of choice for primary and secondary hepatic tumors but only 15-25% of patients with hepatic colorectal metastases are eligible for a curative hepatic resection. Cryosurgical ablation (CSA) is employed when curative resection of metastases cannot be obtained. Sixty-four patients (35 males, 29 females, mean age 58.8 years, range 30-79 years) with hepatic colorectal metastases underwent CSA, under laparoscopic control (15 cases) or with open surgery (49 cases), with subsequent close follow-up...
December 2007: Surgical Oncology
D K Filippou, E D Avgerinos, E Pavlakis, S Rizos
Primary and secondary liver tumors are highly malignant with a very high morbidity and mortality. Although surgical resection is generally accepted as the mainstay of treatment, only a small number of patients are suitable for curative resection. Interventional multimodality therapies provide an alternative to liver resection with minimal morbidity and mortality and quite promising outcomes. These include transcatheter arterial chemoembolization (TACE), percutaneous ethanol (PEI) or other injection techniques, radiofrequency ablation (RFA), microwave coagulation therapy (MCT), cryoablation and interstitial laser photocoagulation (ILP)...
January 2005: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Sharon M Weber, Fred T Lee
Three definitive treatment options are available for patients with hepatic tumors: hepatic resection, tumor ablation, and hepatic transplantation. Ablative techniques--including radiofrequency ablation (RFA) and cryoablation--have greatly improved physicians' ability to definitively treat patients with primary and secondary hepatic tumors. Both RFA and cryoablation are safe and well-tolerated, but the effectiveness for local tumor eradication depends on many factors, including tumor size, location, number, and type...
October 2005: Oncology (Williston Park, NY)
Wolfgang Jungraithmayr, Dieter Burger, Manfred Olschewski, Stefan Eggstein
BACKGROUND: Local ablative procedures such as cryosurgery and thermo-ablation are increasingly employed as a supplement to liver resection for the therapy of primary and secondary liver tumors. It is still unclear if the survival time can be extended through local ablative procedures. This prospective study shows operative actions, complications and long-term follow-up of 19 patients undergoing cryotherapy. METHODS: Between 1997 and 1998, 19 patients underwent cryotherapy due to a non-resectable malignant liver tumor (17 patients with metastases of a colon carcinoma, 2 patients with a hepatocellular carcinoma)...
November 2005: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Christopher J Gannon, Steven A Curley
Surgical resection is often the first-line treatment option for primary and select metastatic hepatic malignancies. A minority of patients with hepatocellular carcinoma undergo potentially curative resection. Similarly, patients with liver-only metastasis are candidates for resection less than 15% of the time because of bilobar disease in which resection would sacrifice too great a volume of hepatic parenchyma, tumor proximity to major vascular or biliary structures thus preventing adequate margins, or unfavorable tumor biology...
October 2005: Seminars in Radiation Oncology
Thomas Kirk Slabaugh, Zurab Machaidze, Randy Hennigar, Kenneth Ogan
BACKGROUND AND PURPOSE: Ablation by cold (cryoablation) or radiofrequency energy (RFA), has been popularized for the treatment of small renal tumors. Regrettably, there currently is no reliable method of radiologically monitoring the propagation of RF lesions in real time. Ultrasonography enhanced by gas-filled microbubble contrast agents allows depiction of regions of tissue perfusion and has been described as a useful adjunct in diagnosing renal pseudotumors, improving prostate biopsy results, and confirming successful ablation of liver tumors...
June 2005: Journal of Endourology
Th Helmberger, R-Th Hoffmann, T Jakobs, Th Leibecke, A Lubienski, M Reiser
Minimal-invasive techniques for ablation of primary and secondary hepatic tumors gain increasingly clinical importance. This is especially true since surgical resection and classic chemotherapy is successful only in a limited number of patients. Local ablative methods incorporate chemo- (percutaneous alcohol instillation, transarterial chemoembolization), thermo- (radiofrequency-, laser-, microwave-, cryoablation, high intensive focused ultrasound) and radio-ablative techniques (interstitial brachytherapy, selective internal radiotherapy)...
January 2005: Der Radiologe
SÅ‚awomir Rudzki, Adam Jamroz
Liver metastases develop in 30-50 per cent of patients with colorectal cancer. Without treatment, the median survival is approximately 7 months. Recent results from multiple investigations indicate that several minimally invasive treatment techniques are very effective for treating primary and secondary malignant hepatic tumors and they may replace surgical resection in the near future. Thermal ablation techniques for the treatment of primary and secondary malignant hepatic tumors include both freezing (cryoablation) and heating (microwave, laser, and high-intensity focused ultrasound) are characterized in this article...
January 2004: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
J K Seifert, D L Morris
BACKGROUND: Carcinoembryonic antigen (CEA) is of prognostic value in colorectal cancer and has been shown to be related to the ability of colorectal cancer cells to implant and to metastasise and to have an effect on immune function. This study attempts to separate the prognostic effects of serum CEA level and volume of hepatic metastases following cryotherapy for liver metastases from colorectal cancer. METHODS: Out of 195 patients undergoing cryotherapy for liver tumour between 4/90 and 5/97 we identified 94 patients who had cryoablation of colorectal liver metastases with known volume of metastases and preoperative serum CEA...
2000: International Journal of Surgical Investigation
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