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https://www.readbyqxmd.com/read/30649303/clinical-outcomes-pharmacologic-treatment-and-quality-of-life-of-patients-with-stable-coronary-artery-diseases-managed-by-cardiologists-1-year-results-of-the-start-study
#1
Leonardo De Luca, Pier Luigi Temporelli, Carmine Riccio, Lucio Gonzini, Lina Marinacci, Sara Norma Tartaglione, Paolo Costa, Marino Scherillo, Michele Senni, Furio Colivicchi, Michele Massimo Gulizia
Aims: We evaluated the 1-year clinical events, pharmacologic management and quality of life in a contemporary cohort of stable coronary artery disease (CAD) patients managed by cardiologists. Methods and Results: START (STable Coronary Artery Diseases RegisTry) was a prospective, observational, nationwide study that enrolled 5070 stable CAD patients over 3 months in 183 cardiology centers in Italy. At 1 year, 4790 (94.5%) patients had data on vital status. Death occurred in 107 (2...
January 14, 2019: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/30638212/-lifestyle-risk-factors-and-prevention-of-cancer-role-of-the-cardiologist
#2
Maurizio G Abrignani, Iris Parrini, Daniele Grosseto, Chiara Lestuzzi, Marinella Mistrangelo, Bruno Passaretti
Although commonly thought of as two separate disease entities, cardiovascular diseases and cancer, the leading causes of death, possess various possible interactions, including a number of similar risk factors (e.g. obesity, diabetes, chronic inflammation). Each cardiologist should provide counseling for a correct lifestyle (diet, physical exercise, avoiding smoking and alcohol abuse); doing so, not only cardiovascular diseases, but also cancer could be prevented. Besides, intervention on diet, physical activity and smoking has been shown to be effective even in patients with known cancers...
January 2019: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/30616901/association-of-statins-aspirin-and-venous-thromboembolism-in-women-with-endometrial-cancer
#3
Koji Matsuo, Marianne S Hom, Akira Yabuno, Masako Shida, Mamoru Kakuda, Sosuke Adachi, Rachel S Mandelbaum, Yutaka Ueda, Kosei Hasegawa, Takayuki Enomoto, Mikio Mikami, Lynda D Roman
OBJECTIVE: The anti-thrombogenic effects of statins and aspirin have been reported in various malignancies but have not been well examined in endometrial cancer. This study examined the association between statin and/or aspirin use and venous thromboembolism (VTE) risk in endometrial cancer. METHODS: This is a multi-center retrospective study examining 2527 women with endometrial cancer between 2000 and 2015. Statin and aspirin use at diagnosis was correlated to VTE risk during follow-up on multivariable analysis...
January 4, 2019: Gynecologic Oncology
https://www.readbyqxmd.com/read/30608575/beta-blocker-aspirin-and-statin-usage-after-first-time-myocardial-infarction-in-patients-with-chronicauthor-information-obstructive-pulmonary-disease-a-nationwide-analysis-from-1995-to-2015-in-denmark
#4
Daniel Bech Rasmussen, Uffe Bodtger, Morten Lamberts, Sia Kromann Nicolaisen, Maurizio Sessa, Annalisa Capuano, Christian Torp-Pedersen, Gunnar Gislason, Peter Lange, Magnus Thorsten Jensen
Aims: To determine whether beta-blockers, aspirin, and statins are underutilized after first-time myocardial infarction (MI)in patients with chronic obstructive pulmonary disease (COPD) compared with patients without COPD. Further, todetermine temporal trends, and risk factors for non-use. Methods and Results: Using Danish nationwide registers, we performed a cross-sectional study investigating the utilization of betablockers, aspirin and statins after hospitalisation for first-time MI among patients with and without COPD from 1995to 2015...
January 4, 2019: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/30598249/medical-therapy-for-atherosclerotic-cardiovascular-disease-in-patients-with-myocardial-injury-after-non-cardiac-surgery
#5
Jin F Chen, Nathaniel R Smilowitz, Jung T Kim, Germaine Cuff, Alina Boltunova, Jason Toffey, Jeffrey S Berger, Andrew Rosenberg, Samir Kendale
BACKGROUND: Myocardial injury after non-cardiac surgery (MINS) is a common post-operative cardiovascular complication and is associated with short and long-term mortality. The objective of this study was to describe the contemporary management of patients with and without MINS after total joint and spine orthopedic surgery at a large urban health system in the United States. METHODS: Adults admitted for total joint and major spine surgery from January 2013 through December 2015 with ≥1 cardiac troponin (cTn) measurement during their hospitalization were identified...
December 12, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30591299/recent-advances-in-therapeutic-targeting-of-inflammation-in-atherosclerosis
#6
REVIEW
Ulf Hedin, Ljubica Perisic Matic
OBJECTIVE: Current prevention of peripheral vascular disease (PVD) focuses on blood pressure control, lipid lowering, and platelet inhibition with statins and aspirin. A critical role for inflammation in the pathophysiology of atherosclerosis has been established for decades and, although both statins and aspirin have anti-inflammatory properties, the management of inflammation is becoming increasingly recognized. Here, we summarize recent clinical and translational discoveries that outline how inflammation may become targeted in PVD in the future...
December 24, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30587515/aspirin-reduces-long-term-stroke-risk-in-women-with-prior-hypertensive-disorders-of-pregnancy
#7
Eliza C Miller, Amelia K Boehme, Nadia T Chung, Sophia S Wang, James V Lacey, Kamakshi Lakshminarayan, Charlie Zhong, Daniel Woo, Natalie A Bello, Ronald Wapner, Mitchell S V Elkind, Joshua Z Willey
OBJECTIVE: To determine whether hypertensive disorders of pregnancy (HDP) increased long-term stroke risk in women in the California Teachers Study (CTS), a prospective cohort study, and whether aspirin or statin use modified this risk. METHODS: CTS participants ≤60 years of age at the time of enrollment in 1995 were followed up prospectively for validated stroke outcomes obtained via linkage with California hospital records through December 31, 2015. We calculated unadjusted and adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the primary outcomes of all stroke and stroke before 60 years of age among those with and without a history of HDP...
December 26, 2018: Neurology
https://www.readbyqxmd.com/read/30563358/prospects-for-the-primary-prevention-of-myocardial-infarction-and-stroke
#8
Madison Caldwell, Lisa Martinez, Jennifer G Foster, Dawn Sherling, Charles H Hennekens
Cardiovascular disease (CVD), principally myocardial infarction (MI) and stroke, is the leading clinical and public health problem in the United States and is rapidly becoming so worldwide. Their primary prevention is promising, in theory, but difficult to achieve in practice. The principal modalities that have demonstrated efficacy include therapeutic lifestyle changes (TLCs) and adjunctive drug therapies under the guidance of the health-care provider and tailored to the individual patient. The prevention and treatment of the pandemic of overweight and obesity and lack of regular physical activity, both of which are alarmingly common in the United States, prevention and treatment of hypertension, avoidance and cessation of cigarette smoking, adoption and maintenance of a healthy diet, and avoidance of heavy alcohol consumption all have proven benefits in decreasing the risks of a first MI and stroke as well as other clinical manifestations of CVD...
December 18, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/30561253/gender-differences-in-patient-reported-outcomes-among-adults-with-atherosclerotic-cardiovascular-disease
#9
Victor Okunrintemi, Javier Valero-Elizondo, Benjamin Patrick, Joseph Salami, Martin Tibuakuu, Saba Ahmad, Oluseye Ogunmoroti, Shiwani Mahajan, Safi U Khan, Martha Gulati, Khurram Nasir, Erin D Michos
Background Atherosclerotic cardiovascular disease ( ASCVD ) accounts for approximately one third of deaths in women. Although there is an established relationship between positive patient experiences, health-related quality of life, and improved health outcomes, little is known about gender differences in patient-reported outcomes among ASCVD patients. We therefore compared gender differences in patient-centered outcomes among individuals with ASCVD . Methods and Results Data from the 2006 to 2015 Medical Expenditure Panel Survey, a nationally representative US sample, were used for this study...
December 18, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30558024/statins-and-gastroduodenal-endoscopic-lesions-a-case-control-study
#10
Monica Pantea, Anca Negovan, Septimiu Voidăzan, Melania Macarie, Simona Mocan, Simona Băţagă
Experimental studies showed a dose-dependent gastroprotective effect of statins on non-steroidal anti-inflammatory drug-induced endoscopic lesions, modulated by increasing endogenous nitric oxide and prostaglandin production.We investigated the influence of chronic treatment with statins on the occurrence of endoscopic lesions in patients referred for endoscopic evaluation, adjusted for the most important etiologic and risk factors for peptic ulcer disease and its complications.A consecutive series of 564 patients who underwent upper digestive endoscopy, stratified according to the severity of endoscopic lesions were recruited...
December 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30543478/quantifying-sex-differences-in-cardiovascular-care-among-patients-evaluated-for-suspected-ischemic-heart-disease
#11
Joseph A Ladapo, John M Pfeifer, James M Pitcavage, Brent A Williams, Alana A Choy-Shan
BACKGROUND: Cardiovascular care sex differences are controversial. We examined sex differences in management and clinical outcomes among patients undergoing noninvasive testing for ischemic heart disease (IHD). METHODS: In a rural integrated healthcare system, we identified adults age 40-79 without diagnosed IHD who underwent initial evaluation with a cardiac stress test with imaging or coronary computed tomographic angiography (CTA), 2013-2014. We assessed sex differences in statin/aspirin therapy, revascularization, and adverse cardiovascular events...
December 13, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/30537987/the-isomir-140-3p-regulated-mevalonic-acid-pathway-as-a-potential-target-for-prevention-of-triple-negative-breast-cancer
#12
Anjana Bhardwaj, Harpreet Singh, Celestine Marie Trinidad, Constance T Albarracin, Kelly K Hunt, Isabelle Bedrosian
BACKGROUND: Prevention of triple-negative breast cancer (TNBC) is hampered by lack of knowledge about the drivers of tumorigenesis. METHODS: To identify molecular markers and their downstream networks that can potentially be targeted for TNBC prevention, we analyzed small RNA and RNA sequencing of a cell line model that represent early stages of TNBC development. We have identified direct gene targets of isomiRNA-140-3p and by using cell-based and in vivo model systems we have demonstrated the utility of targeting downstream pathways for prevention of TNBC...
December 11, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/30529930/sex-differences-in-management-and-outcomes-of-patients-with-stable-symptoms-suggestive-of-coronary-artery-disease-insights-from-the-promise-trial
#13
Neha J Pagidipati, Adrian Coles, Kshipra Hemal, Kerry L Lee, Rowena J Dolor, Patricia A Pellikka, Daniel B Mark, Manesh R Patel, Sheldon E Litwin, Melissa A Daubert, Svati H Shah, Udo Hoffmann, Pamela S Douglas
BACKGROUND: Although sex differences exist in the management of acute coronary syndromes, less is known about the management and outcomes of women and men with suspected coronary artery disease being evaluated with noninvasive testing (NIT). METHODS: We investigated sex-based differences in NIT results and subsequent clinical management in 4,720 women and 4,246 men randomized to CT angiography versus stress testing in the PROMISE trial. Logistic regression models assessed relationships between sex and referral for catheterization, revascularization, and aspirin or statin use...
November 9, 2018: American Heart Journal
https://www.readbyqxmd.com/read/30507932/use-of-statins-or-nsaids-and-survival-of-patients-with-high-grade-glioma
#14
Corinna Seliger, Julia Schaertl, Michael Gerken, Christian Luber, Martin Proescholdt, Markus J Riemenschneider, Michael F Leitzmann, Peter Hau, Monika Klinkhammer-Schalke
BACKGROUND: High-grade glioma (HGG) is associated with a limited prognosis. Drug repurposing has become of increasing interest to improve standard therapy. Statins and NSAIDs inhibit glioma cell growth in vitro and in vivo, but data on statin and NSAID treatment in relation to survival of patients with HGG are sparse. METHODS: We performed multivariable adjusted Cox-regression analyses among 1,093 patients with HGG from a regional cancer registry to obtain Hazard Ratios (HRs) with 95% Confidence Intervals (CIs) for overall survival (OS) and progression-free survival (PFS) according to treatment with statins or NSAIDs...
2018: PloS One
https://www.readbyqxmd.com/read/30485853/intensive-statin-therapy-for-acute-ischemic-stroke-to-reduce-the-number-of-microemboli-a-preliminary-randomized-controlled-study
#15
Xingyu Chen, Xiaorong Zhuang, Zhongwei Peng, Huili Yang, Liangyi Chen, Qingwei Yang
BACKGROUND: To assess whether intensive statin therapy reduces the occurrence of microemboli in patients with acute ischemic stroke. METHODS: Patients with acute ischemic stroke within 72 h of onset were randomized to the intensive statin (atorvastatin 60 mg/day, adjusted to 20 mg/day after 7 days) and control (atorvastatin 20 mg/day) groups. Combined aspirin and clopidogrel were used for antiplatelet therapy. Microemboli were monitored by transcranial Doppler on days 1 (pre-treatment), 3, and 7...
November 28, 2018: European Neurology
https://www.readbyqxmd.com/read/30425764/comparison-of-comorbid-conditions-between-cancer-survivors-and-age-matched-patients-without-cancer
#16
Satyajeet Roy, Shirisha Vallepu, Cristian Barrios, Krystal Hunter
Background: Cancer survivors suffer from many comorbid conditions even after the cure of their cancers beyond 5 years. We explored the differences in the association of comorbid conditions between the cancer survivors and patients without cancer. Methods: Electronic medical records of 280 adult cancer survivors and 280 age-matched patients without cancer in our suburban internal medicine office were reviewed. Results: Mean age of the cancer survivors was 72...
December 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/30402961/cardiovascular-disease-management-in-people-with-diabetes-outside-north-america-and-western-europe-in-2006-and-2015
#17
M Tabesh, D J Magliano, S K Tanamas, F Surmont, S Bahendeka, C-E Chiang, J F Elgart, J J Gagliardino, S Kalra, S Krishnamoorthy, A Luk, H Maegawa, A A Motala, F Pirie, A Ramachandran, K Tayeb, O Vikulova, J Wong, J E Shaw
AIM: Optimal treatment of cardiovascular disease is essential to decrease mortality among people with diabetes, but information is limited on how actual treatment relates to guidelines. We analysed changes in therapeutic approaches to anti-hypertensive and lipid-lowering medications in people with Type 2 diabetes from 2006 and 2015. METHODS: Summary data from clinical services in seven countries outside North America and Western Europe were collected for 39 684 people...
November 6, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30402489/simvastatin-effects-on-inflammation-and-platelet-activation-markers-in-hypercholesterolemia
#18
Cristina Barale, Chiara Frascaroli, Rouslan Senkeev, Franco Cavalot, Isabella Russo
Background: Beside the lipid-lowering effect, statins slow the progression of atherosclerosis by exerting anti-inflammatory and platelet inhibiting effects. We investigated whether platelet inhibition by simvastatin correlates with the statin effects on lipid lowering, inflammation, oxidative stress, and endothelial and platelet activation. Methods: In hypercholesterolemic patients allocated to diet (n=20) or a 2-month treatment with diet plus 40 mg simvastatin (n=25), we evaluated platelet aggregating responses to ADP, collagen, and arachidonic acid (AA), the effect of aspirin on AA-induced aggregation, pro- and anti-inflammatory and atherogenic mediators (IL-1 β , -5, -6, -7, -8, -9, -10, -12, and -13, IFN- γ , IP-10, Eotaxin, and sRAGE), markers of endothelium (sE-selectin, VEGF, and MCP-1) and platelet activation (sP-selectin, sCD-40L, RANTES, and PDGF-bb), and oxidative stress (8-OH-2'-deoxyguanosine)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30376415/prescription-rate-of-anti-atherosclerotic-drugs-in-german-nursing-homes-and-its-impact-on-outcome
#19
Noemi Galas, Ingrid Becker, Tomasz Ficon, Maik Sakrauski, Rita Reichert, Wael Ahmad, Spyridon Mylonas, Jan Brunkwall, Payman Majd
BACKGROUND: Peripheral arterial disease (PAD) is one of the major manifestations of general atherosclerosis and strongly associated with increased cardiovascular morbidity and mortality. Because only few epidemiologic studies are available concerning the prevalence of PAD in inhabitants ≥ 80 years of age, we screened inhabitants of nursing care homes in Germany for PAD and cardiovascular diseases and to assess the one year mortality. PATIENTS AND METHODS: We conducted a prospective cohort study, screening inhabitants of 42 nursing homes for PAD...
October 30, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/30369326/central-obesity-and-visceral-adipose-tissue-are-not-associated-with-incident-atherosclerotic-cardiovascular-disease-events-in-older-men
#20
John T Schousboe, Allyson M Kats, Lisa Langsetmo, Tien N Vo, Brent C Taylor, Ann V Schwartz, Peggy M Cawthon, Cora E Lewis, Elizabeth Barrett-Connor, Andrew R Hoffman, Eric S Orwoll, Kristine E Ensrud
Background Visceral adipose tissue ( VAT ) and other measures of central obesity predict incident atherosclerotic cardiovascular disease ( ASCVD ) events in middle-aged individuals, but these associations are less certain in older individuals age 70 years and older. Our objective was to estimate the associations of VAT and the android-gynoid fat mass ratio, another measure of central obesity, with incident ASCVD events among a large cohort of older men. Methods and Results Two thousand eight hundred ninety-nine men (mean [ SD ] age 76...
August 21, 2018: Journal of the American Heart Association
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