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https://www.readbyqxmd.com/read/30402961/cardiovascular-disease-management-in-people-with-diabetes-outside-north-america-and-western-europe-in-2006-and-2015
#1
M Tabesh, D J Magliano, S K Tanamas, F Surmont, S Bahendeka, C-E Chiang, J F Elgart, J J Gagliardino, S Kalra, S Krishnamoorthy, A Luk, H Maegawa, A A Motala, F Pirie, A Ramachandran, K Tayeb, O Vikulova, J Wong, J E Shaw
AIM: Optimal treatment of cardiovascular disease is essential to decrease mortality among people with diabetes, but information is limited on how actual treatment relates to guidelines. We analysed changes in therapeutic approaches to anti-hypertensive and lipid-lowering medications in people with Type 2 diabetes from 2006 and 2015. METHODS: Summary data from clinical services in seven countries outside North America and Western Europe were collected for 39 684 people...
November 6, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30402489/simvastatin-effects-on-inflammation-and-platelet-activation-markers-in-hypercholesterolemia
#2
Cristina Barale, Chiara Frascaroli, Rouslan Senkeev, Franco Cavalot, Isabella Russo
Background: Beside the lipid-lowering effect, statins slow the progression of atherosclerosis by exerting anti-inflammatory and platelet inhibiting effects. We investigated whether platelet inhibition by simvastatin correlates with the statin effects on lipid lowering, inflammation, oxidative stress, and endothelial and platelet activation. Methods: In hypercholesterolemic patients allocated to diet (n=20) or a 2-month treatment with diet plus 40 mg simvastatin (n=25), we evaluated platelet aggregating responses to ADP, collagen, and arachidonic acid (AA), the effect of aspirin on AA-induced aggregation, pro- and anti-inflammatory and atherogenic mediators (IL-1 β , -5, -6, -7, -8, -9, -10, -12, and -13, IFN- γ , IP-10, Eotaxin, and sRAGE), markers of endothelium (sE-selectin, VEGF, and MCP-1) and platelet activation (sP-selectin, sCD-40L, RANTES, and PDGF-bb), and oxidative stress (8-OH-2'-deoxyguanosine)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30376415/prescription-rate-of-anti-atherosclerotic-drugs-in-german-nursing-homes-and-its-impact-on-outcome
#3
Noemi Galas, Ingrid Becker, Tomasz Ficon, Maik Sakrauski, Rita Reichert, Wael Ahmad, Spyridon Mylonas, Jan Brunkwall, Payman Majd
BACKGROUND: Peripheral arterial disease (PAD) is one of the major manifestations of general atherosclerosis and strongly associated with increased cardiovascular morbidity and mortality. Because only few epidemiologic studies are available concerning the prevalence of PAD in inhabitants ≥ 80 years of age, we screened inhabitants of nursing care homes in Germany for PAD and cardiovascular diseases and to assess the one year mortality. PATIENTS AND METHODS: We conducted a prospective cohort study, screening inhabitants of 42 nursing homes for PAD...
October 30, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/30369326/central-obesity-and-visceral-adipose-tissue-are-not-associated-with-incident-atherosclerotic-cardiovascular-disease-events-in-older-men
#4
John T Schousboe, Allyson M Kats, Lisa Langsetmo, Tien N Vo, Brent C Taylor, Ann V Schwartz, Peggy M Cawthon, Cora E Lewis, Elizabeth Barrett-Connor, Andrew R Hoffman, Eric S Orwoll, Kristine E Ensrud
Background Visceral adipose tissue ( VAT ) and other measures of central obesity predict incident atherosclerotic cardiovascular disease ( ASCVD ) events in middle-aged individuals, but these associations are less certain in older individuals age 70 years and older. Our objective was to estimate the associations of VAT and the android-gynoid fat mass ratio, another measure of central obesity, with incident ASCVD events among a large cohort of older men. Methods and Results Two thousand eight hundred ninety-nine men (mean [ SD ] age 76...
August 21, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30368693/preventing-lethal-prostate-cancer-with-diet-supplements-and-rx-heart-healthy-continues-to-be-prostate-healthy-and-first-do-no-harm-part-i
#5
REVIEW
Mark A Moyad
PURPOSE OF REVIEW: To discuss the overall and latest observations of the effect of diet, lifestyle, supplements, and some prescription heart healthy medications for prostate cancer prevention. RECENT FINDINGS: The concept of maximizing heart health to prevent aggressive prostate cancer continues to be solidified with the addition of more prospective observational and randomized controlled trial data. Heart healthy is prostate healthy, but heart unhealthy is prostate unhealthy...
October 27, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/30366610/protective-propensity-of-race-or-environmental-features-in-the-development-of-barrett-s-esophagus-in-african-americans-a-single-center-pilot-study
#6
Ahmad Alkaddour, Camille McGaw, Rama Hritani, Carlos Palacio, Juan Carlos Munoz, Kenneth J Vega
BACKGROUND AND STUDY AIMS: Barrett's Esophagus (BE) is a well-recognized pre-malignant condition. Previous data indicate histologically confirmed BE frequency varies by ethnicity in the United States. However, clinical factor assessment to explain this has only occurred in a veteran population to date. The study aim was to determine which clinical factors may be associated with the ethnic variation seen in histologically confirmed BE among a general population. PATIENTS AND METHODS: The University of Florida-Jacksonville endoscopy database was searched for all cases of endoscopic BE from September 2002 to October 2012...
October 23, 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/30344063/pre-existing-treatment-with-aspirin-or-statins-influences-clinical-presentation-infarct-size-and-inflammation-in-patients-with-de-novo-acute-coronary-syndromes
#7
Lukas Weidmann, Slayman Obeid, François Mach, Mohammady Shahin, Nooraldaem Yousif, Andrea Denegri, Olivier Muller, Lorenz Räber, Christian M Matter, Thomas F Lüscher
BACKGROUND: Influence of pre-existing treatment with aspirin and/or statins prior to a first acute coronary syndrome (ACS) on clinical presentation, infarct size and inflammation markers. We analyzed patients from the Swiss Program University Medicine ACS-cohort (SPUM-ACS; ClinicalTrials.govnumber:NCT01075867). METHODS: 1639 patients were categorized into 4 groups: (1)patients without either drug (n=1181); (2)patients only on aspirin (n=157); (3)patients only on statins (n=133) and (4)patients on both drugs (n=168)...
October 16, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30342297/the-international-polycap-study-3-tips-3-design-baseline-characteristics-and-challenges-in-conduct
#8
Philip Joseph, Prem Pais, Antonio L Dans, Jackie Bosch, Denis Xavier, Patricio Lopez-Jaramillo, Khalid Yusoff, Anwar Santoso, Shamim Talukder, Habib Gamra, Karen Yeates, Paul Camacho Lopez, Jessica Tyrwhitt, Peggy Gao, Koon Teo, Salim Yusuf
BACKGROUND: It is hypothesized that in individuals without clinical cardiovascular disease (CVD), but at increased CVD risk, a 50% to 60% reduction in CVD risk could be achieved using fixed dose combination (FDC) therapy (usually comprised of multiple blood-pressure agents and a statin [with or without aspirin]) in a single "polypill". However, the impact of a polypill in preventing clinical CV events has not been evaluated in a large randomized controlled trial. METHODS: TIPS-3 is a 2x2x2 factorial randomized controlled trial that will examine the effect of a FDC polypill on major CV outcomes in a primary prevention population...
August 2, 2018: American Heart Journal
https://www.readbyqxmd.com/read/30335000/early-severe-coronary-heart-disease-and-ischemic-heart-failure-in-homozygous-familial-hypercholesterolemia-a-case-report
#9
Hongyu Kuang, Xue Zhou, Li Li, Qijian Yi, Weinian Shou, Tiewei Lu
RATIONALE: Familial hypercholesterolemia (FH) is a common inherited cause of coronary heart disease (CHD) and premature death in an early age. Nevertheless, an ischemic heart failure (IHF) associated with FH seems to be rare, and an early diagnosis and therapy could influence the prognosis. PATIENT CONCERNS: In this 13-year-old girl, multiple xanthomas began to develop from the first day of birth. Until June, 2017, she was admitted to our center due to edema, oliguria, and dyspnea during exertion, which was attributed to a recent respiratory infection...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30332575/should-aspirin-be-used-for-primary-prevention-in-the-post-statin-era
#10
EDITORIAL
Paul M Ridker
New England Journal of Medicine, Volume 379, Issue 16, Page 1572-1574, October 2018.
October 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/30318297/acute-coronary-syndromes-in-patients-with-active-hematologic-malignancies-incidence-management-and-outcomes
#11
Jae Yoon Park, Wei Guo, Mohammed Al-Hijji, Abdallah El Sabbagh, Kebede H Begna, Thomas M Habermann, Thomas E Witzig, Bradley R Lewis, Amir Lerman, Joerg Herrmann
BACKGROUND: Cancer and cardiovascular diseases are the two leading causes of death in industrialized countries. Optimal management of life-threatening presentations of both of their diseases can pose significant challenges. The current study aimed to address the incidence, management, and outcome of acute coronary syndromes (ACS) in patients with active hematological malignancies. METHODS: This retrospective registry-based cohort study included adults with active leukemia or lymphoma who were hospitalized at Mayo Clinic Rochester from 01/01/2004 to 12/31/2014...
October 5, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30295098/embracing-the-polypill-as-a-cardiovascular-therapeutic-is-this-the-best-strategy
#12
Beata Franczyk, Anna Gluba-Brzózka, Łukasz Jurkiewicz, Peter Penson, Maciej Banach, Jacek Rysz
Cardiovascular disease (CVD) is an important cause of mortality and morbidity worldwide. CVD morbidity and mortality are associated with significant financial costs related to hospitalization, medication, and lost productivity. The concept of the 'polypill' for the reduction of cardiovascular risk was proposed in 2000. A polypill is a fixed combination of drugs in a single tablet or capsule. The initial polypill consisted of three different classes of antihypertensive drugs (each at half dose), in addition to aspirin, a statin, and folic acid...
October 8, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/30293849/-is-cancer-a-factor-or-a-marker-of-cardiovascular-risk-in-women
#13
REVIEW
Stéphane Ederhy, Yann Ancedy, Laurie Soulat-Dufour, Marion Chauvet-Droit, Ariel Cohen
Cardiovascular diseases and cancers are the 2 main causes of mortality in industrialized countries. Cancer and cardiovascular disease share molecular and pathophysiological mechanisms involved in both cardiovascular disease and cancer development. Some prescribed therapies for primary or secondary prevention of cardiovascular disease (statin, aspirin) may have effects on the cancer plan. Physical activity would be particularly beneficial in reducing the risk of colorectal cancer, breast and endometrial cancer in women...
September 2018: La Presse Médicale
https://www.readbyqxmd.com/read/30293793/impact-of-diabetes-on-coronary-artery-plaque-volume-by-coronary-ct-angiography-and-subsequent-adverse-cardiac-events
#14
Simon Deseive, Ramona Straub, Maximilian Kupke, Alexander Broersen, Pieter H Kitslaar, Thomas J Stocker, Steffen Massberg, Martin Hadamitzky, Jörg Hausleiter
BACKGROUND: To investigate the impact of diabetes on coronary artery total plaque volume (TPV) and adverse events in long-term follow-up. METHODS: One-hundred-and-eight diabetic patients were matched to 324 non-diabetic patients, with respect to age, sex, body-mass index, hypertension, smoking habits, LDL and HDL cholesterol, family history for CAD as well as aspirin and statin medication. In all patients, TPV was quantified from coronary CT angiographies (CTA) using dedicated software...
October 1, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/30292611/metabolic-syndrome-is-associated-with-increased-cardiac-morbidity-after-infrainguinal-bypass-surgery-irrespective-of-the-use-of-cardiovascular-risk-modifying-agents
#15
Rebecca Sorber, Andrew Lehman, Husain N Alshaikh, Christopher J Abularrage, James H Black, Ying Wei Lum
BACKGROUND: The burden of metabolic syndrome (MetS) is increasing in the United States and is pervasive among patients with peripheral arterial disease. Whereas MetS has been implicated in the development of all types of cardiovascular disease and adverse outcomes after vascular interventions, little is known about how MetS influences perioperative outcomes of lower extremity bypass surgery and whether any negative effects can be modified by use of cardiovascular risk-modifying medications...
October 3, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30286494/-update-esc-guideline-2017-focus-on-pad
#16
Roberto Sansone, Lucas Busch, Ralf Langhoff
The updated ESC guidelines on PAD were developed, for the first time, as a collaboration between cardiologists and vascular surgeons and unveiled at the European Society of Cardiology (ESC) 2017 congress. Although awareness has improved, PAD is still associated with significant morbidity, mortality, and quality of life impairment. Primarily, the guidelines emphasize the need for a multidisciplinary management of these patients and propose "a vascular team". A new chapter on antithrombotic therapies is provided...
October 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/30249291/determinants-of-drug-related-problems-among-ambulatory-type-2-diabetes-patients-with-hypertension-comorbidity-in-southwest-ethiopia-a-prospective-cross-sectional-study
#17
Mohammed Yimama, Habtemu Jarso, Tigestu Alemu Desse
OBJECTIVE: The aim of this study was to assess drug-related problems and its determinants in type 2 diabetes patients with hypertension co-morbidity. RESULTS: A total of 300 type 2 diabetes patients with hypertension co-morbidity were studied. The majority of participants, 194 (64.7%), were males. Mean age of the participants was 54.44 ± 11.68 years. The mean durations of diabetes and hypertension were 5.37 ± 4.79 and 5.15 ± 4.65 years respectively...
September 24, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/30234774/optimal-sbp-targets-in-routine-clinical-care
#18
Lisanne A Gitsels, Elena Kulinskaya, Ilyas Bakbergenuly, Nicholas Steel
OBJECTIVE: Compare outcomes of intensive treatment of SBP to less than 120 mmHg versus standard treatment to less than 140 mmHg in the US clinical Systolic Blood Pressure Intervention Trial (SPRINT) with similar hypertensive patients managed in routine primary care in the United Kingdom. METHODS: Hypertensive patients aged 50-90 without diabetes or chronic kidney disease (CKD) were selected in SPRINT and The Health Improvement Network (THIN) database. Patients were enrolled in 2010-2013 and followed-up to 2015 (SPRINT N = 4112; THIN N = 8631)...
September 17, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/30228857/treatment-outcomes-and-associated-factors-among-hospitalized-stroke-patients-at-shashemene-referral-hospital-ethiopia
#19
Tegegne Gobezie Temesgen, Berhanu Teshome, Peter Njogu
Background: The 2013 Global Burden of Disease report indicated that 80% of stroke deaths occur in low- and middle-income regions. Although stroke has been consistently reported as one of the three leading causes of morbidity and mortality in the past years in Ethiopia, there is a paucity of data regarding treatment outcomes of stroke if sufficient. Hence, the present study aimed to assess patterns of treatment outcomes and associated factors among hospitalized stroke patients at Shashemene Referral Hospital...
2018: Stroke Research and Treatment
https://www.readbyqxmd.com/read/30220322/protective-effects-of-metformin-statins-and-anti-inflammatory-drugs-on-head-and-neck-cancer-a-systematic-review
#20
REVIEW
Constanza Saka Herrán, Enric Jané-Salas, Albert Estrugo Devesa, José López-López
The main objective of this study was to evaluate the effect of metformin, statins and anti-inflammatory drugs (NSAIDs) on head and neck cancer (HNC). Specifically, the potential beneficial effects on risk, survival and recurrence based on epidemiological studies. PRISMA guidelines were followed. After searching MEDLINE (PubMed), IBECS, LILACS and the Cochrane Central Register for Controlled Trials, 13 studies met the inclusion criteria and so underwent qualitative synthesis (six studies for metformin and seven for NSAIDs)...
October 2018: Oral Oncology
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