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https://www.readbyqxmd.com/read/29788951/managing-acute-ischaemic-stroke-in-a-small-island-developing-state-meeting-the-guidelines-in-barbados
#1
Asanchia S Harewood-Marshall, Leslie S Craig, Tanya P Martelly, David O C Corbin, Lauren Maul, Damani McIntosh-Clarke, Tracey Blackman, Kenneth S George, Anselm J M Hennis, Ian R Hambleton, Angela M C Rose
BACKGROUND: We describe hospital-based management of acute ischaemic stroke patients in 2010-2013 in Barbados, by comparing documented treatment given in the single tertiary public hospital with international guideline recommendations. METHODS: Evidence-based stroke management guidelines were identified through a systematic literature search. Comparisons were made between these guidelines and documented diagnostic practice (all strokes) and prescribed medication (ischaemic stroke only), using a combination of key informant interviews and national stroke registry data for 2010-2013...
May 22, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29781097/aspirin-and-statin-use-for-management-of-atherosclerotic-cardiovascular-disease-in-liver-transplant-candidates-are-we-missing-the-mark
#2
EDITORIAL
Lisa B VanWagner
No abstract text is available yet for this article.
May 21, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29770171/risk-of-gastric-cancer-development-after-eradication-of-helicobacter-pylori
#3
REVIEW
Ka-Shing Cheung, Wai K Leung
Helicobacter pylori ( H. pylori ) infection is the most important risk factor for gastric cancer (GC) development through the Correa's gastric carcinogenesis cascade. However, H. pylori eradication alone does not eliminate GC, as pre-neoplastic lesions (atrophic gastritis, intestinal metaplasia and dysplasia) may have already developed in some patients. It is therefore necessary to identify patients at high-risk for gastric cancer after H. pylori eradication to streamline the management plan. If the patients have not undergone endoscopy with histologic assessment, the identification of certain clinical risk factors and non-invasive testing (serum pepsinogen) can predict the risk of atrophic gastritis...
May 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29763272/colorectal-cancer-screening-and-prevention
#4
Thad Wilkins, Danielle McMechan, Asif Talukder
Colorectal cancer is a common cause of morbidity and mortality in the United States. Most colorectal cancers arise from preexisting adenomatous or serrated polyps. The incidence and mortality of colorectal cancer can be reduced with screening of average-risk adults 50 to 75 years of age. Randomized controlled trials show evidence of reduced colorectal cancer-specific mortality with guaiac-based fecal occult blood tests and flexible sigmoidoscopy. There are no randomized controlled trials on the effectiveness of colonoscopy to reduce colorectal cancer-specific mortality; however, several randomized controlled trials comparing colonoscopy with other strategies are in progress...
May 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29713486/plasma-cytokines-and-risk-of-coronary-heart-disease-in-the-procardis-study
#5
Robert Clarke, Elsa Valdes-Marquez, Michael Hill, Joanne Gordon, Martin Farrall, Anders Hamsten, Hugh Watkins, Jemma C Hopewell
Objective: The aims of the study were to examine the associations of plasma levels of five cytokines (interleukin (IL)-6, IL-5, interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) and IL-6 receptor (IL-6R)) and C reactive protein (CRP) with risk of coronary heart disease (CHD). Methods: In a case-control study of 931 CHD cases and 974 controls, logistic regression was used to estimate the OR and 95% CI of CHD for extreme thirds of biomarkers after adjustment for established risk factors...
2018: Open Heart
https://www.readbyqxmd.com/read/29712745/impact-of-intensive-versus-standard-blood-pressure-management-by-tertiles-of-blood-pressure-in-sprint-systolic-blood-pressure-intervention-trial
#6
Brian P Shapiro, Walter T Ambrosius, Joseph L Blackshear, William C Cushman, Paul K Whelton, Suzanne Oparil, Srinivasan Beddhu, Jamie P Dwyer, Lisa H Gren, William J Kostis, Michael Lioudis, Roberto Pisoni, Clive Rosendorff, William E Haley
Intensive systolic blood pressure (SBP) control improved outcomes in SPRINT (Systolic Blood Pressure Intervention Trial). Our objective was to expand on reported findings by analysis of baseline characteristics, primary outcomes, adverse events, follow-up blood pressure, and medication use differences by baseline SBP (tertile 1 [T1], <132; tertile 2 [T2], 132-145; and tertile 3 [T3], >145 mm Hg). Participants with higher baseline SBP tertile were more often women and older, had higher cardiovascular risk, and lower utilization of antihypertensive medications, statins, and aspirin...
April 30, 2018: Hypertension
https://www.readbyqxmd.com/read/29703600/vascular-toxicities-with-vegf-inhibitor-therapies-focus-on-hypertension-and-arterial-thrombotic-events
#7
REVIEW
Rhian M Touyz, Sandra M S Herrmann, Joerg Herrmann
The vascular endothelial growth factor (VEGF) signaling pathway (VSP) fulfills a cardinal role in endothelial cells and its inhibition has profound cardiovascular impact. This is true not only for the normal vasculature but also for the tumor vasculature when VSP inhibitors are used as anti-angiogenic therapies. Generalized endothelial dysfunction predisposes to vasoconstriction, atherosclerosis, platelet activation, and thrombosis (arterial more than venous). All of these have been reported with VSP inhibitors and collectively give rise to vascular toxicities, the most concerning of which are arterial thromboembolic events (ATE)...
March 21, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29681616/progress-in-preventive-therapy-for-cancer-a-reminiscence-and-personal-viewpoint
#8
REVIEW
Jack Cuzick
Prophylactic drug treatment with aspirin, statins and anti-hypertensive agents has had a major impact on the incidence of cardiovascular disease and is now well established. Progress in therapeutic cancer prevention has been much slower; only recently have effective agents been clearly established. Breast cancer has led the way and endocrine agents used to treat it-notably tamoxifen and the aromatase inhibitors-have now been shown to have a substantial preventive effect as well. However, these agents carry some toxicity and thus identifying high-risk women who are likely to benefit most is a key priority...
April 23, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29671538/stable-coronary-artery-disease-treatment
#9
Michael M Braun, William A Stevens, Craig H Barstow
Stable coronary artery disease refers to a reversible supply/demand mismatch related to ischemia, a history of myocardial infarction, or the presence of plaque documented by catheterization or computed tomography angiography. Patients are considered stable if they are asymptomatic or their symptoms are controlled by medications or revascularization. Treatment involves risk factor management, antiplatelet therapy, and antianginal medications. Tobacco cessation, exercise, and weight loss are the most important lifestyle modifications...
March 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29667200/treatment-in-a-preventive-cardiology-clinic-utilizing-advanced-practice-providers-apps-effectively-closes-atherosclerotic-cardiovascular-disease-ascvd-risk-management-gaps-amongst-a-primary-prevention-population-compared-with-a-propensity-matched-primary-care
#10
Emilio Fentanes, Anthony G Vande Hei, R Scott Holuby, Norma Suarez, Yousif Slim, Jennifer N Slim, Ahmad M Slim, Dustin Thomas
BACKGROUND: Advanced Practice Providers (APPs) can fill access to care gaps created by physician shortages and improve adherence/compliance with preventive atherosclerotic cardiovascular disease (ASCVD) interventions. METHODS: We retrospectively reviewed data on 595 patients enrolled in a preventive cardiology clinic (PCC) utilizing APPs compared with a propensity-matched cohort (PMC) of 595 patients enrolled in primary care clinics alone. PCC patients were risk stratified using Framingham risk scoring (FRS) and coronary artery calcium scoring (CACS) and treated based on published guideline-based algorithms...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29664030/do-practice-gaps-exist-in-evidence-based-medication-prescription-at-hospital-discharge-in-patients-undergoing-coronary-artery-bypass-surgery-coronary-angioplasty
#11
Pradeep Pereira, Aditya Kapoor, Archana Sinha, Surendra K Agarwal, Shantanu Pande, Roopali Khanna, Nilesh Srivastava, Sudeep Kumar, Naveen Garg, Satyendra Tewari, Pravin Goel
Background & objectives: Prescription patterns of guideline-directed medical therapy (GDMT) after coronary artery bypass surgery [coronary artery bypass graft (CABG)] and percutaneous coronary intervention (PCI) at hospital discharge are often not optimal. In view of scarce data from the developing world, a retrospective analysis of medication advice to patients following CABG and PCI was conducted. Methods: Records of 5948 patients (post-PCI: 5152, post-CABG: 796) who underwent revascularization from 2010 to 2014 at a single tertiary care centre in north India were analyzed...
December 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29661588/impact-of-metabolic-diseases-drugs-and-dietary-factors-on-prostate-cancer-risk-recurrence-and-survival-a-systematic-review-by-the-european-association-of-urology-section-of-oncological-urology
#12
REVIEW
Riccardo Campi, Sabine D Brookman-May, Jose Daniel Subiela Henríquez, Bülent Akdoğan, Maurizio Brausi, Tobias Klatte, Johan F Langenhuijsen, Estefania Linares-Espinos, Martin Marszalek, Morgan Roupret, Christian G Stief, Alessandro Volpe, Andrea Minervini, Oscar Rodriguez-Faba
CONTEXT: To date, established risk factors for prostate cancer (PCa) are limited to age, race, family history, and certain genetic polymorphisms. Despite great research efforts, available evidence on potentially modifiable risk factors is conflicting. Moreover, most studies on PCa risk factors did not consider the impact of prostate-specific antigen (PSA) testing on PCa diagnosis. OBJECTIVE: To provide a detailed overview of the latest evidence on the role of metabolic diseases, drugs, and dietary factors for risk of PCa incidence, recurrence, and survival in men exposed to PSA testing...
April 13, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29652176/medication-use-in-women-and-men-with-sudden-unexpected-death
#13
Sonalie Patel, Mitchell M Conover, Golsa Joodi, Sarah Chen, Ross J Simpson, Zachariah M Deyo
BACKGROUND: In Wake County, NC, sudden unexpected death accounts for 10% to 15% of all natural deaths in individuals 18 to 64 years old. Medications such as aspirin, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, statins, and β-blockers are recommended in guidelines to reduce cardiovascular events and even sudden death (β-blockers). However, guidelines are often underpracticed, even in high-risk patients, with noted disparities in women. OBJECTIVE: We assessed the relation between prescription of evidence-based medications and sudden unexpected death in Wake County, NC...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29624871/utilization-of-aspirin-and-statin-in-management-of-coronary-artery-disease-in-patients-with-cirrhosis-undergoing-liver-transplant-evaluation
#14
Samarth S Patel, Luis Guzman, Fei-Pi Lin, Taylor Pence, Trevor Reichman, Binu John, Francesco S Celi, Erika Liptrap, Chandra Bhati, Mohammad S Siddiqui
Coronary artery disease (CAD) assessment is vital part of liver transplantation (LT) evaluation as it allows for identification and medical optimization prior to transplantation. Although aspirin and statins are standard of care for CAD, they are not universally used in cirrhosis due to concerns of adverse events. METHODS: Per protocol, coronary angiography was performed as part of LT evaluation in all patients over the age of 50 years or with CAD risk factors even if they were younger than 50...
April 6, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29622506/cost-effectiveness-of-a-fixed-dose-combination-polypill-in-secondary-prevention-of-cardiovascular-diseases-in-india-within-trial-cost-effectiveness-analysis-of-the-umpire-trial
#15
Kavita Singh, Catriona Crossan, Tracey-Lea Laba, Ambuj Roy, Alison Hayes, Abdul Salam, Stephen Jan, Joanne Lord, Nikhil Tandon, Anthony Rodgers, Anushka Patel, Simon Thom, Dorairaj Prabhakaran
BACKGROUND: The Use of Multidrug Pill In Reducing cardiovascular Events (UMPIRE) trial, showed that access to a cardiovascular polypill (aspirin, statin and two blood pressure lowering drugs) significantly improved adherence, lowered systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDLc) in patients with or at high risk of cardiovascular disease (CVD). We aimed to analyze the within-trial cost-effectiveness of the polypill strategy versus usual care in India. METHODS: Relative effectiveness and costs of polypill versus usual care groups in UMPIRE were estimated from the health sector perspective...
March 21, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29610608/pharmacotherapy-evaluation-and-utilization-in-coronary-artery-bypass-grafting-patients-in-kosovo-during-the-period-2016-2017
#16
Armond Daci, Adnan Bozalija, Raif Cavolli, Rame Alaj, Giangiacomo Beretta, Shaip Krasniqi
BACKGROUND: Coronary Artery Bypass Grafting (CABG) is realised in patients with critical or advanced disease of coronary arteries. There are different pharmacotherapeutic approaches which are used as management, treatment and preventive therapy in cardiovascular disease or related comorbidities. Performing a successful surgery, pharmacotherapy, and increase of bypass patency rate remains a serious challenge. AIM: This study aims to analyse the patient characteristics undergoing CABG and evaluation of their drug utilisation rate and daily dosages in the perioperative period...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29587290/chemoprevention-and-treatment-of-pancreatic-cancer-update-and-review-of-the-literature
#17
Julia Benzel, Volker Fendrich
BACKGROUND: Pancreatic ductal adenocarcinoma is one of the most lethal types of cancer with a 5-year survival rate of around 7%. Due to the relatively poor prognosis, the potential need of an effective chemoprevention is highly needed. SUMMARY: Different risk factors like smoking or hereditary tumour syndromes should be known for early detection of pancreatic intraepithelial neoplasia. Chemopreventive dietary agents include curcumin, capsaicin and flavonoid, whereas potential chemopreventive drugs compromise aspirin, metformin or statins...
2018: Digestion
https://www.readbyqxmd.com/read/29582403/medications-and-prescribing-patterns-as-factors-associated-with-hospitalizations-from-long-term-care-facilities-a-systematic-review
#18
REVIEW
Kate N Wang, J Simon Bell, Esa Y H Chen, Julia F M Gilmartin-Thomas, Jenni Ilomäki
BACKGROUND: Residents of long-term care facilities (LTCFs) are at high risk of hospitalization. Medications are a potentially modifiable risk factor for hospitalizations. OBJECTIVE: Our objective was to systematically review the association between medications or prescribing patterns and hospitalizations from LTCFs. METHODS: We searched MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and International Pharmaceutical Abstracts (IPA) from inception to August 2017 for longitudinal studies reporting associations between medications or prescribing patterns and hospitalizations...
March 26, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29582106/trends-and-variations-in-the-prescribing-of-secondary-preventative-cardiovascular-therapies-for-non-st-elevation-myocardial-infarction-nstemi-in-malaysia
#19
Padmaa Venkatason, Nur Lisa Zaharan, Muhammad Dzafir Ismail, Wan Azman Wan Ahmad, Ahmad Syadi Mahmood Zuhdi
PURPOSE: Information is lacking on prescribing of preventative cardiovascular pharmacotherapies for patients with non-ST elevation myocardial infarction (NSTEMI) in the Asian region. This study examined the prescribing rate of these pharmacotherapies, comparing NSTEMI to STEMI, and variations across demographics and clinical factors within the NSTEMI group in the multi-ethnic Malaysian population. METHODS: This is a retrospective analysis of the Malaysian National Cardiovascular Disease Database-Acute Coronary Syndrome registry from year 2006 to 2013 (n = 30,873)...
March 26, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29581926/morphine-oxygen-nitrates-and-mortality-reducing-pharmacological-treatment-for-acute-coronary-syndrome-an-evidence-based-review
#20
REVIEW
José Nunes de Alencar Neto
Since it was first reported in 1912, acute coronary syndrome (ACS) has become the leading cause of death in the Western world. Several improvements that have been made over the years in the pharmacological treatment of ACS have reduced the relative risk of death due to myocardial infarction from 35-45% previously to approximately 3.5% at present. Universities, websites, and educational videos commonly use a mnemonic for morphine, oxygen, nitrates, and aspirin (MONA) to refer to the adjuvant treatment used for the management of ACS...
January 25, 2018: Curēus
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