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https://www.readbyqxmd.com/read/30234774/optimal-sbp-targets-in-routine-clinical-care
#1
Lisanne A Gitsels, Elena Kulinskaya, Ilyas Bakbergenuly, Nicholas Steel
OBJECTIVE: Compare outcomes of intensive treatment of SBP to less than 120 mmHg versus standard treatment to less than 140 mmHg in the US clinical Systolic Blood Pressure Intervention Trial (SPRINT) with similar hypertensive patients managed in routine primary care in the United Kingdom. METHODS: Hypertensive patients aged 50-90 without diabetes or chronic kidney disease (CKD) were selected in SPRINT and The Health Improvement Network (THIN) database. Patients were enrolled in 2010-2013 and followed-up to 2015 (SPRINT N = 4112; THIN N = 8631)...
September 17, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/30228857/treatment-outcomes-and-associated-factors-among-hospitalized-stroke-patients-at-shashemene-referral-hospital-ethiopia
#2
Tegegne Gobezie Temesgen, Berhanu Teshome, Peter Njogu
Background: The 2013 Global Burden of Disease report indicated that 80% of stroke deaths occur in low- and middle-income regions. Although stroke has been consistently reported as one of the three leading causes of morbidity and mortality in the past years in Ethiopia, there is a paucity of data regarding treatment outcomes of stroke if sufficient. Hence, the present study aimed to assess patterns of treatment outcomes and associated factors among hospitalized stroke patients at Shashemene Referral Hospital...
2018: Stroke Research and Treatment
https://www.readbyqxmd.com/read/30220322/protective-effects-of-metformin-statins-and-anti-inflammatory-drugs-on-head-and-neck-cancer-a-systematic-review
#3
REVIEW
Constanza Saka Herrán, Enric Jané-Salas, Albert Estrugo Devesa, José López-López
The main objective of this study was to evaluate the effect of metformin, statins and anti-inflammatory drugs (NSAIDs) on head and neck cancer (HNC). Specifically, the potential beneficial effects on risk, survival and recurrence based on epidemiological studies. PRISMA guidelines were followed. After searching MEDLINE (PubMed), IBECS, LILACS and the Cochrane Central Register for Controlled Trials, 13 studies met the inclusion criteria and so underwent qualitative synthesis (six studies for metformin and seven for NSAIDs)...
October 2018: Oral Oncology
https://www.readbyqxmd.com/read/30197243/vasospastic-angina-a-literature-review-of-current-evidence
#4
REVIEW
Fabien Picard, Neila Sayah, Vincent Spagnoli, Julien Adjedj, Olivier Varenne
Vasospastic angina (VSA) is a variant form of angina pectoris, in which angina occurs at rest, with transient electrocardiogram modifications and preserved exercise capacity. VSA can be involved in many clinical scenarios, such as stable angina, sudden cardiac death, acute coronary syndrome, arrhythmia or syncope. Coronary vasospasm is a heterogeneous phenomenon that can occur in patients with or without coronary atherosclerosis, can be focal or diffuse, and can affect epicardial or microvasculature coronary arteries...
September 6, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/30188953/chronic-obstructive-pulmonary-disease-with-short-acting-inhaled-pharmacotherapy-increases-the-risk-of-prostate-cancer-a-two-stage-database-approach
#5
Hui-Wen Lin, Li-Fong Lin, Hung-Chou Chen, Tsan-Hon Liou, Shih-Wei Huang
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) are at a higher risk of many types of cancer. However, specific investigation of the risk of prostate cancer and the influence of COPD pharmacotherapy in patients with COPD is lacking. This study investigated the risk and influence of COPD pharmacotherapy on risk of prostate cancer in patients with COPD. METHODS: This retrospective cohort study used data from Taiwan's Longitudinal Health Insurance Database 2005 (LHID2005)...
2018: PloS One
https://www.readbyqxmd.com/read/30188885/vital-signs-prevalence-of-key-cardiovascular-disease-risk-factors-for-million-hearts-2022-united-states-2011-2016
#6
Hilary K Wall, Matthew D Ritchey, Cathleen Gillespie, John D Omura, Ahmed Jamal, Mary G George
INTRODUCTION: Despite decades-long reductions in cardiovascular disease (CVD) mortality, CVD mortality rates have recently plateaued and even increased in some subgroups, and the prevalence of CVD risk factors remains high. Million Hearts 2022, a 5-year initiative, was launched in 2017 to address this burden. This report establishes a baseline for the CVD risk factors targeted for reduction by the initiative during 2017-2021 and highlights recent changes over time. METHODS: Risk factor prevalence among U...
September 7, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/30188374/pharmacogenetic-and-clinical-predictors-of-response-to-clopidogrel-plus-aspirin-after-acute-coronary-syndrome-in-egyptians
#7
Shaimaa Fathy, Mohamed H Shahin, Taimour Langaee, Basma M Khalil, Ayman Saleh, Nagwa A Sabry, Mona F Schaalan, Lamiaa L El Wakeel, Larisa H Cavallari
OBJECTIVES: Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel reduces the risk for recurrent cardiovascular events after acute coronary syndrome (ACS). However, there is significant variation in response to DAPT that may be influenced by both genetic and nongenetic factors. This study aimed to assess the effect of genetic polymorphisms in PON-1, PEAR-1, P2Y12, CES1, and CYP2C19, along with clinical, demographic, and social factors, on variation in response to DAPT in Egyptians...
September 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/30182363/new-drug-candidates-for-depression-a-nationwide-population-based-study
#8
L V Kessing, H C Rytgaard, T A Gerds, M Berk, C T Ekstrøm, P K Andersen
OBJECTIVE: To investigate whether continued use of non-aspirin NSAID, low-dose aspirin, high-dose aspirin, statins, allopurinol and angiotensin agents decreases the rate of incident depression using Danish nationwide population-based registers. METHODS: All persons in Denmark who purchased the exposure medications of interest between 1995 and 2015 and a random sample of 30% of the Danish population was included in the study. Two different outcome measures were included, (i) a diagnosis of depressive disorder at a psychiatric hospital as in-patient or out-patient and (ii) a combined measure of a diagnosis of depression or use of antidepressants...
September 4, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/30180958/safety-of-diagnostic-and-therapeutic-cardiac-catheterization-in-cancer-patients-with-acute-coronary-syndrome-and-chronic-thrombocytopenia
#9
Cezar Iliescu, Dinu V Balanescu, Teodora Donisan, Dana E Giza, Ezequiel D Muñoz Gonzalez, Mehmet Cilingiroglu, Juhee Song, Siddharth S Mukerji, Juan C Lopez-Mattei, Peter Y Kim, Nicolas Palaskas, Elie N Mouhayar, Jean-Bernard Durand, Konstantinos Marmagkiolis
Little data is available on the bleeding risk and outcomes of cancer patients with chronic thrombocytopenia who underwent cardiac catheterization. We sought to assess the safety of coronary angiography, percutaneous coronary intervention, and antiplatelet therapy in cancer patients with acute coronary syndrome (ACS) and chronic thrombocytopenia. We performed a retrospective study of patients with chronic thrombocytopenia who underwent cardiac catheterization for ACS between November 2009 and November 2015. Preprocedural platelet counts were classified into 3 groups: mild thrombocytopenia (50,000 to 100,000/µL), moderate thrombocytopenia (30,000 to 50,000/µL), and severe thrombocytopenia (<30,000/µL)...
August 3, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30165650/opportunities-for-intervention-stroke-treatments-disability-and-mortality-in-urban-tanzania
#10
Robert W Regenhardt, Maijo R Biseko, Agness F Shayo, Theoflo N Mmbando, Sara J Grundy, Ai Xu, Altaf Saadi, Leah Wibecan, G Abbas Kharal, Robert Parker, Joshua P Klein, Farrah J Mateen, Kigocha Okeng'o
Objective: Given the high post-stroke mortality and disability and paucity of data on the quality of stroke care in Sub-Saharan Africa, we sought to characterize the implementation of stroke-focused treatments and 90-day outcomes of neuroimaging-confirmed stroke patients at the largest referral hospital in Tanzania. Design: Prospective cohort study. Setting: Muhimbili National Hospital (MNH) in Dar es Salaam, July 2016-March 2017. Participants: Adults with new-onset stroke (<14 days), confirmed by head CT, admitted to MNH...
August 28, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/30106222/disease-characteristics-and-treatment-of-patients-with-diabetes-mellitus-attending-government-health-services-in-indonesia-peru-romania-and-south-africa
#11
Nanny N M Soetedjo, Susan M McAllister, Cesar Ugarte-Gil, Adela G Firanescu, Katharina Ronacher, Bachti Alisjahbana, Anca L Costache, Carlos Zubiate, Stephanus T Malherbe, Raspati C Koesoemadinata, Yoko V Laurence, Fiona Pearson, Sarah Kerry-Barnard, Rovina Ruslami, David A J Moore, Mihai Ioana, Leanie Kleynhans, Hikmat Pernama, Philip C Hill, Maria Mota, Gerhard Walzl, Hazel M Dockrell, Julia A Critchley, Reinout van Crevel
OBJECTIVE: To describe the characteristics and management of Diabetes mellitus (DM) patients from low- and middle-income countries (LMIC). METHODS: We systematically characterized consecutive DM patients attending public health services in urban settings in Indonesia, Peru, Romania and South Africa, collecting data on DM treatment history, complications, drug treatment, obesity, HbA1c, and cardiovascular risk profile; and assessing treatment gaps against relevant national guidelines...
August 14, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/30105597/obstetric-anti-phospholipid-syndrome-state-of-the-art
#12
REVIEW
Maria Chiara Gerardi, Melissa Alexandre Fernandes, Angela Tincani, Laura Andreoli
PURPOSE OF REVIEW: This review focuses on new pathogenesis and clinical-therapeutic aspects of obstetric anti-phospholipid syndrome (ob-APS) in the last 5 years. RECENT FINDINGS: The pathogenesis of ob-APS is multifactorial, including placental infarctions, infiltration of inflammatory cells that cause acute and chronic inflammation, leading to uncontrolled inflammation and poor pregnancy outcomes. A preconception counseling and a patient-tailored treatment are fundamental to improve maternal and fetal outcomes...
August 13, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/30101855/outcomes-in-patients-with-critical-limb-ischemia-due-to-arteriosclerosis-obliterans-who-did-not-undergo-arterial-reconstruction
#13
Daisuke Akagi, Katsuyuki Hoshina, Atsushi Akai, Kota Yamamoto
The prevalence of arteriosclerosis obliterans (ASO) and critical limb ischemia (CLI) is currently increasing, and arterial reconstruction is often attempted to salvage the limb. Some patients cannot undergo attempted revascularization because of contraindications, and they only receive conservative treatment. In this study, we investigate the comorbidities and survival rates of patients with CLI who receive conservative treatment. Thirty-five patients with CLI due to ASO, who had not undergone revascularization surgery (C group), were enrolled...
August 11, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30100675/towards-standardization-of-training-and-practice-of-reconstructive-microsurgery-an-evidence-based-recommendation-for-anastomosis-thrombosis-prophylaxis
#14
REVIEW
Marie C Kearns, Jill Baker, Simon Myers, Ali Ghanem
Background: Despite significant improvements in survival rates, free flap failures still occur even in experienced hands and are most commonly due to arterial or venous thrombosis. In the absence of an evidence-based guideline on the prevention of thrombosis, we reviewed the literature to assess the evidence base for commonly used interventions aimed at its prevention. Methods: A comprehensive literature search was performed using the following keywords "free flap" and microsurgery with "pre-operative screening," "prevention of thrombosis," "ketorolac," "heparin," "low molecular weight heparin," "aspirin," "dextran," and "statins...
2018: European Journal of Plastic Surgery
https://www.readbyqxmd.com/read/30096840/clinically-relevant-anti-inflammatory-agents-for-chemoprevention-of-colorectal-cancer-new-perspectives
#15
REVIEW
Altaf Mohammed, Nagendra Sastry Yarla, Venkateshwar Madka, Chinthalapally V Rao
Substantial efforts are underway for prevention of early stages or recurrence of colorectal cancers (CRC) or new polyp formation by chemoprevention strategies. Several epidemiological, clinical and preclinical studies to date have supported the chemopreventive potentials of several targeted drug classes including non-steroidal anti-inflammatory drugs (NSAIDs) (aspirin, naproxen, sulindac, celecoxib, and licofelone), statins and other natural agents-both individually, and in combinations. Most preclinical trials although were efficacious, only few agents entered clinical trials and have been proven to be potential chemopreventive agents for colon cancer...
August 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30081159/metformin-is-associated-with-improved-survival-and-decreased-cardiac-events-with-no-impact-on-patency-and-limb-salvage-after-revascularization-for-peripheral-arterial-disease
#16
Sikandar Z Khan, Mariel Rivero, Nader D Nader, Gregory S Cherr, Linda M Harris, Maciej L Dryjski, Hasan H Dosluoglu
BACKGROUND: The incidence of cardiovascular and limb-specific adverse outcomes is higher in peripheral arterial disease (PAD) patients with diabetes. Metformin is associated with improved cardiovascular morbidity and mortality. However, the effect of metformin on limb-specific outcomes is unclear. The objective of this study was to assess the effect of metformin on outcomes after intervention for PAD. METHODS: Patients who underwent revascularization for chronic limb ischemia (Rutherford 3-6) between June 2001 and December 2014 were retrospectively identified...
August 4, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30044331/actual-impact-of-screening-for-myocardial-ischemia-with-single-photon-emission-tomography-among-patients-undergoing-peripheral-vascular-interventions
#17
Mariana Corneli, Osvaldo Masoli, Gabriel Perea, Alejandro Meretta, Gustavo Daquarti, Daniel Rosa, Fernando Belcastro, Ruth Henquin, Néstor Perez Baliño
The present study provides actual data with regard to the prevalence of myocardial ischemia among patients under contemporary cardiovascular prevention strategies undergoing peripheral vascular interventions. We included a total of 200 consecutive patients who underwent gated single-photon emission computed tomography myocardial perfusion study between January 2012 and January 2014 as preoperative evaluation for peripheral vascular interventions at our institution. The baseline medical treatment comprised aspirin (81%), statins (79%), and β-blockers (54%)...
September 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30039172/evaluation-of-the-pooled-cohort-risk-equations-for-cardiovascular-risk-prediction-in-a-multiethnic-cohort-from-the-women-s-health-initiative
#18
Samia Mora, Nanette K Wenger, Nancy R Cook, Jingmin Liu, Barbara V Howard, Marian C Limacher, Simin Liu, Karen L Margolis, Lisa W Martin, Nina P Paynter, Paul M Ridker, Jennifer G Robinson, Jacques E Rossouw, Monika M Safford, JoAnn E Manson
Importance: Atherosclerotic cardiovascular disease (ASCVD) kills approximately 1 in every 3 US women. Current cholesterol, hypertension, and aspirin guidelines recommend calculating 10-year risk of ASCVD using the 2013 Pooled Cohort Equations (PCE). However, numerous studies have reported apparent overestimation of risk with the PCE, and reasons for overestimation are unclear. Objective: We evaluated the predictive accuracy of the PCE in the Women's Health Initiative (WHI), a multiethnic cohort of contemporary US postmenopausal women...
September 1, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/30035118/cardiac-magnetic-resonance-in-stable-coronary-artery-disease-added-prognostic-value-to-conventional-risk-profiling
#19
Oronzo Catalano, Guido Moro, Alessia Mori, Mariarosa Perotti, Alessandra Gualco, Mauro Frascaroli, Clara Pesarin, Carlo Napolitano, Ntobeko A B Ntusi, Silvia G Priori
Aims: Cardiovascular magnetic resonance ( CMR) permits a comprehensive evaluation of stable coronary artery disease (CAD). We sought to assess whether, in a large contemporaneous population receiving optimal medical therapy, CMR independently predicts prognosis beyond conventional cardiovascular risk factors (RF). Methods: We performed a single centre, observational prospective study that enrolled 465 CAD patients (80% males; 63±11 years), optimally treated with ACE-inhibitors/ARB, aspirin, and statins (76-85%)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30034255/evidence-based-complementary-treatment-of-pancreatic-cancer-a-review-of-adjunct-therapies-including-paricalcitol-hydroxychloroquine-intravenous-vitamin-c-statins-metformin-curcumin-and-aspirin
#20
REVIEW
Stephen Bigelsen
Despite new and exciting research and renewed optimism about future therapy, current statistics of survival from pancreatic cancer remains dismal. Patients seeking alternative or complementary treatments should be warned to avoid the hype and instead look to real science. A variety of relatively safe and inexpensive treatment options that have shown success in preclinical models and/or retrospective studies are currently available. Patients require their physicians to provide therapeutic guidance and assistance in obtaining and administrating these various therapies...
2018: Cancer Management and Research
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