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Statin aspirin

Thomas Olsen, Kathrine J Vinknes, Gard Ft Svingen, Eva R Pedersen, Indu Dhar, Grethe S Tell, Rune Blomhoff, Per M Ueland, Øivind Midttun, Helga Refsum, Ottar K Nygård
Background Plasma total homocysteine (tHcy) has been implicated in the development of cardiovascular disease, but the mechanisms remain unclear. Vitamin A (Vit-A) is involved in homocysteine metabolism and we therefore explored the potential interaction between plasma tHcy and serum Vit-A in relation to incident acute myocardial infarction. Methods Cox proportional hazards models were used to assess the prospective relationships between tHcy and acute myocardial infarction in 2205 patients from Western Norway undergoing elective coronary angiography for suspected stable angina pectoris...
January 1, 2018: European Journal of Preventive Cardiology
Bernadette Aliprandi-Costa, Lucy Morgan, Lan-Chi Snell, Mario D Souza, Leonard Kritharides, John French, David Brieger, Isuru Ranasinghe
BACKGROUND: Increased access to reperfusion for ST elevation myocardial infarction (STEMI) has contributed to reduced mortality internationally. We describe temporal trends in pre-hospital care, in-hospital management and outcomes of the STEMI population in Australia. METHODS: Temporal trends with multiple regression analysis on the management and outcomes of STEMI patients enrolled across 46 Australian hospitals in the Australian cohort of the Global Registry of Acute Coronary Events (GRACE) and the Cooperative National Registry of Acute Coronary Care Guideline Adherence and Clinical Events (CONCORDANCE) between February 1999 and August 2016...
June 11, 2018: Heart, Lung & Circulation
Dorota Danielak, Marta Karaźniewicz-Łada, Franciszek Główka
The introduction of ticagrelor, one of the first directly-acting oral antiplatelet drugs, provided new possibilities in the prevention of thrombotic events in patients with acute coronary syndromes (ACS). Current guidelines recommend ticagrelor in dual antiplatelet therapy with aspirin over clopidogrel for prevention of stent thrombosis in patients with ACS. Moreover, in the management of ACS, lipid-lowering treatment with high-intensity statin therapy is advised for secondary prevention of cardiovascular events over the long term...
July 12, 2018: Drugs
Janet Wei, Chrisandra Shufelt, C Noel Bairey Merz
PURPOSE OF REVIEW: When patients are seen for persistent chest pain in the absence of obstructive coronary artery disease, the physician must decide if the symptoms are due to myocardial ischemia in order to guide treatment. RECENT FINDINGS: Recent findings indicate that ischemia due to coronary microvascular dysfunction (CMD) is associated with subclinical coronary atherosclerosis and an adverse prognosis. Therapeutic probe trials suggest that antiatherosclerotic and anti-ischemic therapeutic strategies may be useful...
July 5, 2018: Current Opinion in Cardiology
K L Cheung, N A Zakai, P W Callas, G Howard, B K Mahmoodi, C A Peralta, S E Judd, M Kurella Tamura, M Cushman
BACKGROUND: Chronic kidney disease (CKD) is associated with venous thromboembolism (VTE) risk via unknown mechanisms. Whether factors associated with reduced VTE in the general population might also be associated with reduced risk in CKD is unknown. OBJECTIVES: To determine whether thrombosis biomarkers attenuate VTE risk and if factors associated with reduced VTE are similarly effective in CKD. METHODS: Baseline biomarkers were measured in a case-cohort (294 VTE cases, 939 non-cases) from the REGARDS study, a nationwide prospective cohort of 30,239 persons age ≥45 with 4...
July 8, 2018: Journal of Thrombosis and Haemostasis: JTH
Nele Brusselaers, Jesper Lagergren
OBJECTIVES: Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) are potential candidates for chemoprevention of gastrointestinal cancer. We aimed to assess the association between contemporary NSAID use (≥180 days) and gastrointestinal cancer. DESIGN: Nationwide Swedish population-based cohort study (2005-2012). SETTING: Sweden PARTICIPANTS: All adults exposed to maintenance NSAIDs use (aspirin, n=783 870; unselective NSAIDs, n=566 209, selective cyclo-oxygenase (COX)-2 inhibitors, n=17 948) compared with the Swedish background population of the same age, sex and calendar period...
July 7, 2018: BMJ Open
Ajar Kochar, Anita Y Chen, Puza P Sharma, Neha J Pagidipati, Gregg C Fonarow, Patricia A Cowper, Matthew T Roe, Eric D Peterson, Tracy Y Wang
BACKGROUND: There is limited information about the long-term survival of older patients after myocardial infarction (MI). METHODS AND RESULTS: CRUSADE (Can rapid risk stratification of unstable angina patients suppress adverse outcomes with early implementation of the ACC/AHA guidelines) was a registry of MI patients treated at 568 US hospitals from 2001 to 2006. We linked MI patients aged ≥65 years in CRUSADE to their Medicare data to ascertain long-term mortality (defined as 8 years post index event)...
June 30, 2018: Journal of the American Heart Association
Chin-Hsiao Tseng
BACKGROUND: Whether metformin may reduce hepatocellular carcinoma (HCC) risk requires confirmation. METHODS: Type 2 diabetes patients newly diagnosed during 1999-2005 and with 2 or more prescriptions of antidiabetic drugs were enrolled from the Taiwan's National Health Insurance database. A total of 173 917 ever-users and 21 900 never-users of metformin were identified (unmatched cohort). A 1:1 matched-pair cohort of 21 900 ever-users and 21 900 never-users based on a propensity score (PS) was created...
June 29, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
M C Tan, H B El-Serag, X Yu, A P Thrift
BACKGROUND: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) may reduce the risk of oesophageal adenocarcinoma (OAC) in Barrett's oesophagus; however, current epidemiologic studies are inconclusive. AIM: To evaluate the independent effects of PPIs and H2RAs on risk of OAC in patients with Barrett's oesophagus. METHODS: We conducted a nested case-control study of male veterans diagnosed with Barrett's oesophagus. Cases with incident OAC were matched by incidence density sampling on birth year and Barrett's diagnosis date to controls with Barrett's oesophagus who did not develop OAC...
June 29, 2018: Alimentary Pharmacology & Therapeutics
Vanessa Selak, Ruth Webster, Sandrine Stepien, Chris Bullen, Anushka Patel, Simon Thom, Bruce Arroll, Michiel L Bots, Alex Brown, Sue Crengle, Prabhakaran Dorairaj, C Raina Elley, Diederick E Grobbee, Matire Harwood, Graham S Hillis, Tracey-Lea Laba, Bruce Neal, David Peiris, Natasha Rafter, Christopher Reid, Alice Stanton, Andrew Tonkin, Tim Usherwood, Angela Wadham, Anthony Rodgers
OBJECTIVE: The aim of this study was to determine the effect of polypill-based care on the achievement of 2016 European Society of Cardiology (ESC) guideline targets for blood pressure (BP), low-density lipoprotein (LDL) cholesterol and antiplatelet therapy. METHODS: We conducted an individual participant data meta-analysis of three randomised clinical trials that compared a strategy using a polypill containing aspirin, statin and antihypertensive therapy with usual care in patients with a prior cardiovascular disease (CVD) event or who were at high risk of their first event...
June 28, 2018: Heart: Official Journal of the British Cardiac Society
Wenpei Yu, Bin Wang, Bin Zhan, Qiang Li, Yingsha Li, Zhiming Zhu, Zhencheng Yan
OBJECTIVE: To investigate whether statin intervention will improve the long-term prognosis of patients undergoing major non-cardiac vascular surgeries. METHODS: Major database searches for clinical trials enrolling patients undergoing major non-cardiac vascular surgeries, including lower limb revascularization, carotid artery surgeries, arteriovenous fistula, and aortic surgeries, were performed. Subgroup analyses, stratified by surgical types or study types, were employed to obtain statistical results regarding survival, patency rates, amputation, and cardiovascular and stroke events...
June 25, 2018: Vascular Pharmacology
Joakim Alfredsson, Jennifer B Green, Susanna R Stevens, Shelby D Reed, Paul W Armstrong, M Angelyn Bethel, Samuel S Engel, Darren K McGuire, Frans Van de Werf, Irene Hramiak, Harvey D White, Eric D Peterson, Rury R Holman
AIM: To examine sex differences in baseline characteristics and outcomes in patients with type 2 diabetes and atherosclerotic vascular disease. MATERIALS AND METHODS: Cox models were used to analyse the association between sex and outcomes in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS), a randomized, placebo-controlled trial assessing the impact of sitagliptin on cardiovascular (CV) outcomes in patients with type 2 diabetes and atherosclerotic vascular disease...
June 19, 2018: Diabetes, Obesity & Metabolism
Sadanori Okada, Takeshi Morimoto, Hisao Ogawa, Mio Sakuma, Chisa Matsumoto, Hirofumi Soejima, Masafumi Nakayama, Naofumi Doi, Hideaki Jinnouchi, Masako Waki, Izuru Masuda, Yoshihiko Saito
OBJECTIVE: This study analyzed the efficacy of low-dose aspirin in cancer chemoprevention in patients with diabetes. RESEARCH DESIGN AND METHODS: This study was a posttrial follow-up of the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) trial. Participants in the JPAD trial (2,536 Japanese patients with type 2 diabetes and without preexisting cardiovascular disease) were randomly allocated to receive aspirin (81 or 100 mg daily) or no aspirin...
June 16, 2018: Diabetes Care
Tomás Romero, Kristina L Greenwood, Dale Glaser
BACKGROUND: Acute myocardial infarction (AMI) sex disparities in management and outcomes have long been attributed to multiple factors, although questions regarding their relevance have not been fully addressed. OBJECTIVE: The aim of this study was to identify current factors associated with sex-related AMI management and outcomes disparities in hospitals with comparable quality care standards. METHODS: This is a cross-sectional study of 299 women and 540 men with AMI discharged in 2013 from 3 southern California hospitals with tertiary cardiac care...
June 6, 2018: Journal of Cardiovascular Nursing
Steve Yadlowsky, Rodney A Hayward, Jeremy B Sussman, Robyn L McClelland, Yuan-I Min, Sanjay Basu
Background: The 2013 pooled cohort equations (PCEs) are central in prevention guidelines for cardiovascular disease (CVD) but can misestimate CVD risk. Objective: To improve the clinical accuracy of CVD risk prediction by revising the 2013 PCEs using newer data and statistical methods. Design: Derivation and validation of risk equations. Setting: Population-based. Participants: 26 689 adults aged 40 to 79 years without prior CVD from 6 U...
July 3, 2018: Annals of Internal Medicine
Cecilia Beatrice Chighizola, Pier Luigi Meroni
PURPOSE OF REVIEW: The aim of this review is to provide an update of the therapeutic tools for thrombotic anti-phospholipid syndrome (APS), focusing on the last 5 years. RECENT FINDINGS: Early studies appointed anticoagulation at moderate intensity as the mainstay of treatment of thrombotic APS; in the last 5 years, the strategy has not much mutated. Some uncertainties regarding the role of direct oral anticoagulants and the optimal regimen for arterial thrombotic APS still persist: high-intensity anticoagulation, anticoagulation plus anti-platelet agent, and double anti-platelet agents being the possible alternatives...
May 31, 2018: Current Rheumatology Reports
Kota Murai, Kenji Sakata, Tomohito Mabuchi, Masato Yamaguchi, Masayuki Mori, Kenshi Hayashi, Masa-Aki Kawashiri
A 52-year-old man was admitted to our hospital because of acute anteroseptal myocardial infarction. After a bare metal stent (BMS) was implanted in the left anterior descending artery (LAD), aspirin, clopidogrel, statin, angiotensin II receptor blocker, and β blocker were prescribed. 6 years later, however, the patient stopped taking all medication by himself. Further 2 years later, the patient was admitted to our hospital again with chest pain, and emergent coronary angiography showed the total occlusion of the LAD at the site where the previous stent was deployed...
April 2018: Cardiovascular Diagnosis and Therapy
Derek Klarin, Richard P Cambria, Emel A Ergul, Scott B Silverman, Virendra I Patel, Glenn M LaMuraglia, Mark F Conrad, W Darrin Clouse
OBJECTIVE: Although carotid atherosclerotic-mediated stroke remains a major cause of morbidity and mortality, some have suggested intervention in carotid stenosis should be limited to symptomatic patients given the advances in medical therapy. The present study was conducted to assess the atherosclerotic risk factor profiles, anatomic features, and clinical outcomes of previously asymptomatic patients admitted with stroke of carotid etiology. METHODS: We reviewed the data from 3382 patients admitted to a tertiary referral center with an ischemic stroke during 2005 to 2015...
May 24, 2018: Journal of Vascular Surgery
Asanchia S Harewood-Marshall, Leslie S Craig, Tanya P Martelly, David O C Corbin, Lauren Maul, Damani McIntosh-Clarke, Tracey Blackman, Kenneth S George, Anselm J M Hennis, Ian R Hambleton, Angela M C Rose
BACKGROUND: We describe hospital-based management of acute ischaemic stroke patients in 2010-2013 in Barbados, by comparing documented treatment given in the single tertiary public hospital with international guideline recommendations. METHODS: Evidence-based stroke management guidelines were identified through a systematic literature search. Comparisons were made between these guidelines and documented diagnostic practice (all strokes) and prescribed medication (ischaemic stroke only), using a combination of key informant interviews and national stroke registry data for 2010-2013...
May 22, 2018: BMC Public Health
Lisa B VanWagner
No abstract text is available yet for this article.
May 21, 2018: Liver Transplantation
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