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https://www.readbyqxmd.com/read/29913448/rapid-electrical-stimulation-increased-cardiac-apoptosis-through-disturbance-of-calcium-homeostasis-and-mitochondrial-dysfunction-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#1
Le Geng, Zidun Wang, Chang Cui, Yue Zhu, Jiaojiao Shi, Jiaxian Wang, Minglong Chen
BACKGROUND/AIMS: Heart failure induced by tachycardia, the most common arrhythmia, is frequently observed in clinical practice. This study was designed to investigate the underlying mechanisms. METHODS: Rapid electrical stimulation (RES) at a frequency of 3 Hz was applied on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for 7 days, with 8 h/day and 24 h/day set to represent short-term and long-term tachycardia, respectively. Age-matched hiPSC-CMs without electrical stimulation or with slow electrical stimulation (1 Hz) were set as no electrical stimulation (NES) control or low-frequency electrical stimulation (LES) control...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29912729/in-vitro-effects-of-the-fs50-protein-from-salivary-glands-of-xenopsylla-cheopis-on-voltage-gated-sodium-channel-activity-and-motility-of-mda-mb-231-human-breast-cancer-cells
#2
Bei Zhang, Zhenghui Deng, Baishuang Zeng, Shilong Yang, Xin Chen, Xueqing Xu, Jiguo Wu
Voltage-gated sodium channel activity enhances the motility and oncogene expression of metastasic cancer cells that express a neonatal alternatively spliced form of the NaV1.5 isoform. We reported previously that FS50, a salivary protein from Xenopsylla cheopis, showed inhibitory activity against the NaV1.5 channel when assayed in HEK 293T cells and antiarrhythmia effects on rats and monkeys after induction of arrhythmia by BaCl2. This study aims to identify the effect of FS50 on voltage-gated sodium channel activity and the motility of MDA-MB-231 human breast cancer cells in vitro...
June 16, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29912584/atrial-fibrillation-in-young-patients
#3
Jean-Baptiste Gourraud, Paul Khairy, Sylvia Abadir, Rafik Tadros, Julia Cadrin-Tourigny, Laurent Macle, Katia Dyrda, Blandine Mondesert, Marc Dubuc, Peter G Guerra, Bernard Thibault, Denis Roy, Mario Talajic, Lena Rivard
Atrial fibrillation (AF) is the most frequent arrhythmia worldwide. While mostly seen in elderly, it can also affect young adults (≤45 years of age), older adolescent and children. Areas covered: The aim of this review is to provide an overview of the current management of AF in young patients. Specific issues arise over diagnostic workup as well as antiarrhythmic and anticoagulation therapies. The future management and diagnostic strategies are also discussed. Expert commentary: Management of AF in the young adult is largely extrapolated from adult studies and guidelines...
June 18, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29912236/-dual-atrioventricular-nodal-pathways-physiology-arrhythmic-findings-and-electrocardiographic-manifestations
#4
Marcello Costantini, Vincenzo Carbone, Lorenzo Costantini
The atrioventricular (AV) node is an anatomically well-defined structure, conveniently housed in the triangle of Koch. There are two distinct atrial impulse approaches to the AV node, one of which (in the anterior portion of triangle of Koch) has a faster conduction, while the other one (in the posterior portion) has a slower conduction. However, it is not said that such a conductive duality translates into any arrhythmic phenomena. Actually, these arrhythmias are due to an imbalance of the two pathways electrophysiological properties, which does not always exist...
April 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29911345/evaluation-of-new-generation-loop-recorders-placed-during-surgical-ablation-for-atrial-fibrillation
#5
Zachary DeBoard, John R Doty
BACKGROUND: Current postsurgical atrial fibrillation (AF) ablation guidelines encourage serial rhythm evaluation; however, traditional Holter monitoring may be cumbersome for patients and yield limited data. An implantable loop recorder (LR) may provide increased data on the incidence of postablation arrhythmias. We sought to evaluate the use of a new generation LR implanted during surgical AF ablation. METHODS: A retrospective analysis was performed on adult patients undergoing surgical AF ablation...
June 17, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29911319/inhibitory-control-in-typically-developing-preschoolers-relations-among-temperament-respiratory-sinus-arrhythmia-and-behavior-at-age-4
#6
Raha Hassan, Kimberly L Day, Ryan J Van Lieshout, Louis A Schmidt
Although inhibitory control (IC) is associated with children's positive adjustment, we know relatively little about factors underlying its development. We examined whether baseline and on-task respiratory sinus arrhythmia [(RSA); a physiological measure of self-regulation] and private speech (a behavioral measure of self-regulation) interacted to confer differences on directly observed IC in 52 typically developing 4-year olds. We found that baseline RSA moderated the association between private speech and IC, such that private speech positively predicted IC in children with relatively higher baseline RSA, but was unrelated to IC in children with relatively lower RSA...
June 17, 2018: Developmental Psychobiology
https://www.readbyqxmd.com/read/29909950/-management-of-mitral-valve-stenosis-during-pregnancy-at-the-oran-university-hospital-center-about-83-cases
#7
N F Benatta, D D Batouche, M A Djazouli, S A Zelmat, T Merzouk, L Hammou
INTRODUCTION: The management of pregnancy in patients with mitral valve stenosis disease continues to pose a challenge to the clinician. OBJECTIVE: The aim of study was to evaluate the association between mitral valve stenosis and maternal and fetal out come. MATERIEL AND METHOD: Eighty-three pregnant women with mitral valve disease, followed-up from 2009 to 2012, were prospectively evaluated medical history, NYHA class assessment, ECG and echocardiography were performed during pregnancy and after delivery...
June 14, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29909402/impact-of-exercise-restriction-on-arrhythmic-risk-among-patients-with-arrhythmogenic-right-ventricular-cardiomyopathy
#8
Weijia Wang, Gabriela Orgeron, Crystal Tichnell, Brittney Murray, Jane Crosson, Oliver Monfredi, Julia Cadrin-Tourigny, Harikrishna Tandri, Hugh Calkins, Cynthia A James
BACKGROUND: Prior studies have shown a close link between exercise and development of arrhythmogenic right ventricular cardiomyopathy. How much exercise restriction reduces ventricular arrhythmia (VA), how genotype modifies its benefit, and whether it reduces risk sufficiently to defer implantable cardioverter-defibrillator (ICD) placement in arrhythmogenic right ventricular cardiomyopathy are unknown. METHODS AND RESULTS: We interviewed 129 arrhythmogenic right ventricular cardiomyopathy patients (age: 34...
June 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29909164/-is-it-possible-to-practice-sports-with-an-implantable-cardioverter-defibrillator
#9
Charles Guenancia, Rodrigue Garcia
Why? The potential risks of sport for an ICD recipient include appropriate and inappropriate shocks, device damage and worsening of the underlying cardiopathy. These risks should be compared to the physical and psychological benefits of exercise. Where? Due to different medico-legal contexts and considering the results of recent studies, the new US guidelines are more permissive than the European guidelines regarding sport practice in ICD recipients. Who? The underlying context (structural or electrical cardiopathy, psychological impact) should be assessed before any decision is taken...
June 13, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29908370/gender-differences-in-patients-with-brugada-syndrome-and-arrhythmic-events-data-from-a-survey-on-arrhythmic-events-in-678-patients
#10
Anat Milman, Jean-Baptiste Gourraud, Antoine Andorin, Pieter G Postema, Frederic Sacher, Philippe Mabo, Giulio Conte, Carla Giustetto, Georgia Sarquella-Brugada, Aviram Hochstadt, Sung-Hwan Kim, Jimmy Jm Juang, Shingo Maeda, Yoshihide Takahashi, Tsukasa Kamakura, Takeshi Aiba, Eran Leshem, Yoav Michowitz, Michael Rahkovich, Yuka Mizusawa, Elena Arbelo, Zhengrong Huang, Isabelle Denjoy, Yanushi D Wijeyeratne, Carlo Napolitano, Ramon Brugada, Ruben Casado-Arroyo, Jean Champagne, Leonardo Calo, Jacob Tfelt-Hansen, Silvia G Priori, Masahiko Takagi, Christian Veltmann, Pietro Delise, Domenico Corrado, Elijah R Behr, Fiorenzo Gaita, Gan-Xin Yan, Josep Brugada, Antoine Leenhardt, Arthur A M Wilde, Pedro Brugada, Kengo F Kusano, Kenzo Hirao, Gi-Byoung Nam, Vincent Probst, Bernard Belhassen
BACKGROUND: There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVES: To compare clinical, electrocardiographic (ECG), electrophysiologic (EP) and genetic characteristics between males and females in BrS-patients with their first AE. METHODS: The multicenter Survey on AE in BrS (SABRUS) collected data on first AE in 678 BrS-patients including 619 (91.3%) males and 59 (8...
June 13, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29907698/selective-activation-of-retinoic-acid-%C3%AE-2-receptors-exerts-cardioprotective-effects
#11
Alice Marino, Takuya Sakamoto, Xiao-Han Tang, Lorraine J Gudas, Roberto Levi
We previously discovered that oral treatment with AC261066, a synthetic selective agonist for the retinoic acid β2-receptor (RARβ2), decreases oxidative stress in the liver, pancreas, and kidney of mice fed a high-fat diet (HFD). Since hyperlipidemic states are causally associated with myocardial ischemia and oxidative stress, we have now investigated the effects of AC261066 in an ex-vivo ischemia/reperfusion (I/R) injury model in hearts of two prototypic dysmetabolic mice. We found that a 6-week oral treatment with AC261066 in both genetically hypercholesterolemic (ApoE-/-) and obese (HFD-fed) wild-type mice exerts protective effects when their hearts are subsequently subjected to I/R ex vivo in the absence of added drug...
June 15, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29907655/causes-and-predictors-of-readmission-in-patients-with-atrial-fibrillation-undergoing-catheter-ablation-a-national-population-based-cohort-study
#12
Shilpkumar Arora, Sopan Lahewala, Byomesh Tripathi, Varshil Mehta, Varun Kumar, Divya Chandramohan, Alejandro Lemor, Mihir Dave, Nileshkumar Patel, Nilay V Patel, Ghanshyam Palamaner Subash Shantha, Juan Viles-Gonzalez, Abhishek Deshmukh
BACKGROUND: Reducing readmission after catheter ablation (CA) in atrial fibrillation (AF) is important. METHODS AND RESULTS: We utilized National Readmission Data (NRD) 2010-2014. AF was identified by International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9-CM) diagnostic code 427.31 in the primary field, while first CA of AF was identified via ICD-9 -procedure code 37.34. Any admission within 30 or 90 days of index admission was considered a readmission...
June 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29907652/cardiac-resynchronization-therapy-and-clinical-outcomes-in-continuous-flow-left-ventricular-assist-device-recipients
#13
Rakesh Gopinathannair, Henri Roukoz, Adarsh Bhan, Ashwin Ravichandran, Mustafa M Ahmed, Dmitry Familtsev, Geetha Bhat, Jennifer Cowger, Munazzah Abdullah, Chirag Sandesara, Rahul Dhawan, Emma J Birks, Jaimin R Trivedi, Mark S Slaughter
BACKGROUND: Many patients with heart failure continue cardiac resynchronization therapy (CRT) after continuous flow left ventricular assist device (CF-LVAD) implant. We report the first multicenter study to assess the impact of CRT on clinical outcomes in CF-LVAD patients. METHODS AND RESULTS: Analysis was performed on 488 patients (58±13 years, 81% male) with an implantable cardioverter defibrillator (ICD) (n=223) or CRT-D (n=265) who underwent CF-LVAD implantation at 5 centers from 2007 to 2015...
June 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29907571/synonymous-nucleotide-modification-of-the-kcnh2-gene-affects-both-mrna-characteristics-and-translation-of-the-encoded-herg-ion-channel
#14
Alexander C Bertalovitz, Marika L Osterbur Badhey, Thomas V McDonald
Synonymous nucleotide variation is increasingly recognized as a factor than can affect protein expression, but the underlying mechanisms are incompletely understood. Here, we investigated whether synonymous changes could affect expression of the potassium voltage gated channel subfamily H member 2 (KCNH2) gene, encoding the human ether-a-go-go related gene (hERG) ion channel which is linked to hereditary cardiac arrhythmia. We examined a previously described synthetic version (hERG-CM) with synonymous substitutions designed to reduce GC content, rare codons, and mRNA secondary structure relative to the native construct (hERG-NT)...
June 15, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29907466/sudden-death-risk-markers-for-patients-with-left-ventricular-ejection-fractions-greater-than-40
#15
REVIEW
Brian P Halliday, Amrit S Lota, Sanjay K Prasad
The major burden of sudden cardiac death (SCD) in patients with heart disease occurs in those with a left ventricular ejection fraction > 40%. Although the annual risk of SCD may be lower in these patients compared to those with lower LVEF, their lifetime cumulative risk of SCD may be greater due to a better overall prognosis. It is plausible that those with LVEF > 40% who are at highest risk of life-threatening arrhythmia will benefit from implantable cardioverter defibrillators. Features that identify patients with a LVEF > 40% at high risk of SCD are urgently needed...
June 12, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29907209/using-artificial-intelligence-to-predict-prolonged-mechanical-ventilation-and-tracheostomy-placement
#16
Joshua Parreco, Antonio Hidalgo, Jonathan J Parks, Robert Kozol, Rishi Rattan
BACKGROUND: Early identification of critically ill patients who will require prolonged mechanical ventilation (PMV) has proven to be difficult. The purpose of this study was to use machine learning to identify patients at risk for PMV and tracheostomy placement. MATERIALS AND METHODS: The Multiparameter Intelligent Monitoring in Intensive Care III database was queried for all intensive care unit (ICU) stays with mechanical ventilation. PMV was defined as ventilation >7 d...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907152/the-effect-of-myocardial-action-potential-duration-on-cardiac-pumping-efficacy-a-computational-study
#17
Da Un Jeong, Ki Moo Lim
BACKGROUND AND AIMS: Although studies on the relation between arrhythmias and the action potential duration (APD) have been carried out, most of them are based only on electrophysiological factors of the heart and lack experiments that consider cardiac mechanical and electromechanical characteristics. Therefore, we conducted this study to clarify the relevance of the shortening of APD of a cell in relation to the mechanical contraction activity of the heart and the associated risk of arrhythmia...
June 15, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29906969/mechanical-perturbation-control-of-cardiac-alternans
#18
Azzam Hazim, Youssef Belhamadia, Stevan Dubljevic
Cardiac alternans is a disturbance in heart rhythm that is linked to the onset of lethal cardiac arrhythmias. Mechanical perturbation control has been recently used to suppress alternans in cardiac tissue of relevant size. In this control strategy, cardiac tissue mechanics are perturbed via active tension generated by the heart's electrical activity, which alters the tissue's electric wave profile through mechanoelectric coupling. We analyze the effects of mechanical perturbation on the dynamics of a map model that couples the membrane voltage and active tension systems at the cellular level...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906523/ventricular-fibromas-in-children-arrhythmia-risk-and-outcomes-a-multicentre-study
#19
John P Jones, Tristan Ramcharan, Milind Chaudhari, Vinay Bhole, Karen Mcleod, Shankar Sadagopan, Orhan Uzun, Andrew Parry, Jan Till, Colin J McMahon, Alan G Stuart, Mark A Walsh
BACKGROUND: Although ventricular fibromas are a rare, they are the second most common type of cardiac tumor in children. While histologically benign, they have a propensity to cause malignant arrhythmias, with cardiac arrest often being the first presentation.; OBJECTIVE: To evaluate the arrhythmia risk, and management strategies for pediatric ventricular fibromas. METHODS: Fifteen centers in the British Paediatric Arrhythmia Group network were contacted to partake in the study to contribute cases...
June 12, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29906289/activation-recovery-interval-imaging-of-premature-ventricular-contraction
#20
Ting Yang, Long Yu, Qi Jin, Liqun Wu, Bin He
Dispersion of ventricular repolarization due to abnormal activation contributes to the susceptibility to cardiac arrhythmias. However, the global pattern of repolarization is difficult to assess clinically. Activation recovery interval (ARI) has been used to understand the properties of ventricular repolarization. In this study, we developed an ARI imaging technique to noninvasively reconstruct three-dimensional (3D) ARI maps in 10 premature ventricular contraction (PVC) patients and evaluated the results with the endocardial ARI maps recorded by a clinical navigation system (CARTO)...
2018: PloS One
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