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Indole-3

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https://www.readbyqxmd.com/read/28726732/characterization-of-the-dioscorin-gene-family-in-dioscorea-alata-reveals-a-role-in-tuber-development-and-environmental-response
#1
Linya Liu, Yacheng Huang, Xiaolong Huang, Jianghua Yang, Wenqiang Wu, Yun Xu, Ziwen Cong, Jun Xie, Wei Xia, Dongyi Huang
Dioscorin is one of the major soluble proteins in yam tubers. Unlike other well-known plant storage proteins, such as patatin and sporamin, dioscorin is argued for its function as storage proteins, and the molecular mechanisms underlying its expressional complexity are little understood. In this study, we isolated five dioscorin genes from Dioscorea alata L., comprising three class A (Da-dio1, -3 and -4) and two class B (Da-dio2 and -5) isoforms. Expressions of all dioscorin genes gradually decreased in mother tubers during yam sprouting and regrowth...
July 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28724262/phytohormones-and-induction-of-plant-stress-tolerance-and-defense-genes-by-seed-and-foliar-inoculation-with-azospirillum-brasilense-cells-and-metabolites-promote-maize-growth
#2
Josiane Fukami, Francisco Javier Ollero, Manuel Megías, Mariangela Hungria
Azospirillum spp. are plant-growth-promoting bacteria used worldwide as inoculants for a variety of crops. Among the beneficial mechanisms associated with Azospirillum inoculation, emphasis has been given to the biological nitrogen fixation process and to the synthesis of phytohormones. In Brazil, the application of inoculants containing A. brasilense strains Ab-V5 and Ab-V6 to cereals is exponentially growing and in this study we investigated the effects of maize inoculation with these two strains applied on seeds or by leaf spray at the V2...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28724188/bisindole-oxadiazole-hybrids-t3p-%C3%A2-mediated-synthesis-and-appraisal-of-their-apoptotic-antimetastatic-and-computational-bcl-2-binding-potential
#3
Pooja R Kamath, Manu M Joseph, Abdul Ajees Abdul Salam, Sreelekha T Therakathinal, Dhanya Sunil, Subhankar Biswas, Karkala Sreedhara Ranganath Pai
In the pursuit of novel anticancer leads, new bisindole-oxadiazoles were synthesized using propyl phosphonic anhydride as a mild and efficient reagent. The molecule, 3-[5-(1H-indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]-1H-indole (3a) exhibited selective cytotoxicity to MCF-7 cells with a cell cycle arrest in the G1 phase. The mechanism of cytotoxicity of 3a involved caspase-2-dependent apoptotic pathway with characteristic apoptotic morphological alterations as observed in acridine orange/ethidium bromide and Hoechst staining...
July 19, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28719347/regulatory-effects-of-the-novel-synthesized-indole-3-carbaldehyde-on-expression-of-cell-cycle-genes-a-study-on-cyclin-d-and-p21-expression-by-acute-promylocytic-leukemia-cell-line-nb4
#4
M N Karimabad, M Mahmoodi, A Jafarzadeh, A Darekordi, M R Hajizadeh, H Khorramdelazad, A R Sayadi, S Khanamani Falahati-Pour, G Hassanshahi
A large variety of heterocycles are known to date and among these, indole and pyran rings are of particular interest. The present investigation was aimed to investigate the effects of novel Indole-3-carbaldehyde derivative (NI-3-CD) analogue on growth inhibition of cells and its regulatory effects on expression of cell cycle genes in acute promylocytic leukemia (APL) cell line. NB4 cells were cultured in presence of RPMI1640 medium contained various concentrations of NI-3-CD and basal compound of indole (I3C) (15...
May 20, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28708056/metarhizium-robertsii-produces-indole-3-acetic-acid-which-promotes-root-growth-in-arabidopsis-and-enhances-virulence-to-insects
#5
Xinggang Liao, Brian Lovett, Weiguo Fang, Raymond J St Leger
The plant root colonizing insect-pathogenic fungus Metarhizium robertsii has been shown to boost plant growth, but little is known about the responsible mechanisms. Here we show that M. robertsii promotes lateral root growth and root hair development of Arabidopsis seedlings in part through an auxin [indole-3-acetic acid (IAA)]-dependent mechanism. M. robertsii, or its auxin-containing culture filtrate promoted root proliferation, activated IAA-regulated gene expression and rescued the root hair defect of the IAA-deficient rhd6 Arabidopsis mutant...
July 15, 2017: Microbiology
https://www.readbyqxmd.com/read/28704702/plant-architecture-auxin-homeostasis-and-phenol-content-in-arabidopsis-thaliana-grown-in-cadmium-and-zinc-enriched-media
#6
Adriano Sofo, Rocco Bochicchio, Mariana Amato, Nunzia Rendina, Antonella Vitti, Maria Nuzzaci, Maria Maddalena Altamura, Giuseppina Falasca, Federica Della Rovere, Antonio Scopa
A screening strategy using micropropagation glass tubes with a gradient of distances between germinating seeds and a metal-contaminated medium was used for studying alterations in root architecture and morphology of Arabidopsis thaliana treated with cadmium (Cd) and zinc (Zn) at the concentration of 10-20μM and 100-200μM, respectively. Metal concentrations in plant shoots and roots were measured by quadrupole inductively coupled plasma mass spectrometry. After 21days from germination, all plants in the tubes were scanned at high resolution and the root systems analyzed...
July 3, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28698639/optimization-of-hormone-combinations-for-root-growth-and-bud-germination-in-chinese-fir-cunninghamia-lanceolata-clone-leaf-cuttings
#7
Shubin Li, Peng Huang, Guochang Ding, Lili Zhou, Piao Tang, Min Sun, Yingying Zheng, Sizu Lin
In order to ascertain the optimal hormone combination for Chinese fir (Cunninghamia lanceolata) leaf cuttings, an L16(4)(4) orthogonal test of 6-benzylaminopurine (6-BA), 1-naphthaleneacetic acid (NAA), and indole-3-butyric acid (IBA) (0, 10, 30, or 50 mg · L(-1) of each exogenous hormone) immersion for 5, 10, 15, or 20 min was conducted. Callus initiation rate and rooting promotion rate were mainly affected by treatment time, root length increase by 6-BA concentration, and bud germination rate and plantlet formation rate by NAA concentration...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28695943/copper-catalyzed-synthesis-of-indolyl-diketones-via-c-h-oxidation-diacylation-of-indoles-with-arylglyoxal-hydrates
#8
Cuiping Wang, Zhiqiang Zhang, Kui Liu, Jingbo Yan, Tiexin Zhang, Gonghao Lu, Qingtao Meng, Haijun Chi, Chunying Duan
An expedient protocol for Cu-catalyzed C-H oxidation/diacylation of indoles with arylglyoxal hydrates to construct indolyl diketones is developed. This methodology exhibits the synthetic utility of the synthesis of an indole-alkaloid 1,2-di(1H-indol-3-yl)ethane-1,2-dione and offers a straightforward means to produce different indolyl nitrogen-containing heterocycles such as indolyl quinoxaline, indolyl hydantoin and indolyl imidazole in high yields. Preliminary mechanistic studies indicate that two proposed pathways are involved in this process...
July 11, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28694431/key-role-for-the-organic-anion-transporters-oat1-and-oat3-in-the-in-vivo-handling-of-uremic-toxins-and-solutes
#9
Wei Wu, Kevin T Bush, Sanjay K Nigam
In vitro data indicates that the kidney proximal tubule (PT) transporters of uremic toxins and solutes (e.g., indoxyl sulfate, p-cresol sulfate, kynurenine, creatinine, urate) include two "drug" transporters of the organic anion transporter (OAT) family: OAT1 (SLC22A6, originally NKT) and OAT3 (SLC22A8). Here, we have examined new and prior metabolomics data from the Oat1KO and Oat3KO, as well as newly obtained metabolomics data from a "chemical double" knockout (Oat3KO plus probenecid). This gives a picture of the in vivo roles of OAT1 and OAT3 in the regulation of the uremic solutes and supports the centrality of these "drug" transporters in independently and synergistically regulating uremic metabolism...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693423/indole-3-butyric-acid-promotes-adventitious-rooting-in-arabidopsis-thaliana-thin-cell-layers-by-conversion-into-indole-3-acetic-acid-and-stimulation-of-anthranilate-synthase-activity
#10
L Fattorini, A Veloccia, F Della Rovere, S D'Angeli, G Falasca, M M Altamura
BACKGROUND: Indole-3-acetic acid (IAA), and its precursor indole-3-butyric acid (IBA), control adventitious root (AR) formation in planta. Adventitious roots are also crucial for propagation via cuttings. However, IBA role(s) is/are still far to be elucidated. In Arabidopsis thaliana stem cuttings, 10 μM IBA is more AR-inductive than 10 μM IAA, and, in thin cell layers (TCLs), IBA induces ARs when combined with 0.1 μM kinetin (Kin). It is unknown whether arabidopsis TCLs produce ARs under IBA alone (10 μM) or IAA alone (10 μM), and whether they contain endogenous IAA/IBA at culture onset, possibly interfering with the exogenous IBA/IAA input...
July 11, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28690187/evaluating-of-oct-4-and-nanog-was-differentially-regulated-by-a-new-derivative-indole-in-leukemia-cell-line
#11
Mojgan Noroozi Karimabad, Mehdi Mahmoodi, Abdollah Jafarzadeh, Ali Darehkordi, Mohammad Reza Hajizadeh, Hossein Khorramdelazad, Ahmad Reza Sayadi, Fariba Rahmani, Gholamhossein Hassanshahi
BACKGROUND: The potential exists to improve treatment through characterization of tumor stem cells and identification of therapeutic targets Using OCT-4 and NANOG genes. Here we have synthesized and investigated the potential of; New Indole-3-carbaldehyde derivative (NI-3-CD) in inhibiting the expression of self-renewal regulatory factors and cancer stem cell gene in a leukemia cell line NB4. METHODOLOGY: The NB4 cells were cultured in RPMI1640 medium contained NI-3-CD and I3F (15...
July 8, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28690133/the-complete-genome-sequence-of-bacillus-velezensis-strain-gh1-13-reveals-agriculturally-beneficial-properties-and-a-unique-plasmid
#12
Sang Yoon Kim, Hajin Song, Mee Kyung Sang, Hang-Yeon Weon, Jaekyeong Song
The bacterial strain Bacillus velezensis GH1-13, isolated from rice paddy soil in Korea, has been shown to promote plant growth and have strong antagonistic activities against pathogens. Here, we report the complete genome sequence of GH1-13, revealing that it possesses a single 4,071,980-bp circular chromosome with 46.2% GC-content. The chromosome encodes 3,930 genes, and we have also identified a unique plasmid in the strain that encodes a further 104 genes (71,628bp and 31.7% GC-content). The genome was found to contain various enzyme-encoding operons, including indole-3-acetic acid (IAA) biosynthesis proteins, 2,3-butanediol dehydrogenase, various non-ribosomal peptide synthetases, and several polyketide synthases...
July 6, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28688659/indole-3-carbinol-is-a-potent-inhibitor-of-ischemia-reperfusion-induced-inflammation
#13
Emmanuel Ampofo, Nico Lachnitt, Jeannette Rudzitis-Auth, Beate M Schmitt, Michael D Menger, Matthias W Laschke
BACKGROUND: Ischemia-reperfusion (I/R) induces tissue inflammation, which is characterized by an increased leukocyte-endothelial cell interaction and leukocyte transmigration. These processes are mediated by the activation of the nuclear factor (NF)κB signaling pathway, resulting in an elevated expression of specific adhesion molecules. The phytochemical indole-3-carbinol (I3C) has been shown to exert anti-inflammatory effects by interfering with NFκB signal transduction. The aim of the present study was to investigate whether I3C is capable of counteracting the pathogenesis of I/R injury...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28688289/antiviral-activity-of-a-synthesized-shikonin-ester-against-influenza-a-h1n1-virus-and-insights-into-its-mechanism
#14
Yahan Zhang, Hongwei Han, Hanyue Qiu, Hongyan Lin, Lugang Yu, Wanzhan Zhu, Jinliang Qi, Rongwu Yang, Yanjun Pang, Xiaoming Wang, Guihua Lu, Yonghua Yang
This study aimed to examine the antiviral effects of shikonin ester ((R)-1-(5, 8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl3-(1H- indol-3-yl) propanoate (PMM-034) against influenza A (H1N1) virus. We investigated PMM-034 anti-H1N1 activity and its effect on caspase 3 gene expression during cellular apoptosis after influenza virus infection in vitro. Neuraminidase (NA) inhibition was assessed in comparison with oseltamivir in the influenza virus standard strains A/PR/8/34 to understand the viral mechanism...
July 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28686261/synthesis-of-1h-indole-3-sulfonates-via-palladium-catalyzed-tandem-reactions-of-2-alkynyl-arylazides-with-sulfonic-acids
#15
Xiaoxiang Zhang, Ping Li, Chang Lyu, Wanxiong Yong, Jing Li, Xinbao Zhu, Weidong Rao
An efficient method for the synthesis of 1H-indole-3-sulfonates via palladium-catalyzed tandem reactions of 2-alkynyl arylazides with sulfonic acids has been developed. The desired products were obtained in good to excellent yields under mild reaction conditions. The reactions were shown to proceed very fast, in most cases, within 10 min.
July 7, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28681302/hydrocarbon-degradation-potential-and-plant-growth-promoting-activity-of-culturable-endophytic-bacteria-of-lotus-corniculatus-and-oenothera-biennis-from-a-long-term-polluted-site
#16
Małgorzata Pawlik, Barbara Cania, Sofie Thijs, Jaco Vangronsveld, Zofia Piotrowska-Seget
Many endophytic bacteria exert beneficial effects on their host, but still little is known about the bacteria associated with plants growing in areas heavily polluted by hydrocarbons. The aim of the study was characterization of culturable hydrocarbon-degrading endophytic bacteria associated with Lotus corniculatus L. and Oenothera biennis L. collected in long-term petroleum hydrocarbon-polluted site using culture-dependent and molecular approaches. A total of 26 hydrocarbon-degrading endophytes from these plants were isolated...
July 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28680437/knots-untie-molecular-determinants-involved-in-knot-formation-induced-by-pseudomonas-savastanoi-in-woody-hosts
#17
REVIEW
Eloy Caballo-Ponce, Jesús Murillo, Marta Martínez-Gil, Alba Moreno-Pérez, Adrián Pintado, Cayo Ramos
The study of the molecular basis of tree diseases is lately receiving a renewed attention, especially with the emerging perception that pathogens require specific pathogenicity and virulence factors to successfully colonize woody hosts. Pathosystems involving woody plants are notoriously difficult to study, although the use of model bacterial strains together with genetically homogeneous micropropagated plant material is providing a significant impetus to our understanding of the molecular determinants leading to disease...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28680092/a-novel-function-for-globulin-in-sequestering-plant-hormone-crystal-structure-of-wrightia-tinctoria-11s-globulin-in-complex-with-auxin
#18
Pramod Kumar, Pooja Kesari, Sonali Dhindwal, Ashish K Choudhary, Madhusudhanarao Katiki, Neetu, Aparna Verma, Kiran Ambatipudi, Shailly Tomar, Ashwani Kumar Sharma, Girish Mishra, Pravindra Kumar
Auxin levels are tightly regulated within the plant cell, and its storage in the isolated cavity of proteins is a measure adopted by cells to maintain the availability of auxin. We report the first crystal structure of Wrightia tinctoria 11S globulin (WTG) in complex with Indole-3-acetic acid (IAA), an auxin, at 1.7 Å resolution. WTG hexamers assemble as a result of the stacking interaction between the hydrophobic surfaces of two trimers, leaving space for the binding of charged ligands. The bound auxin is stabilized by non-covalent interactions, contributed by four chains in each cavity...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28674551/high-mir156-expression-is-required-for-auxin-induced-adventitious-root-formation-via-mxspl26-independent-of-pins-and-arfs-in-malus-xiaojinensis
#19
Xiaozhao Xu, Xu Li, Xingwang Hu, Ting Wu, Yi Wang, Xuefeng Xu, Xinzhong Zhang, Zhenhai Han
Adventitious root formation is essential for the vegetative propagation of perennial woody plants. During the juvenile-to-adult phase change mediated by the microRNA156 (miR156), the adventitious rooting ability decreases dramatically in many species, including apple rootstocks. However, the mechanism underlying how miR156 affects adventitious root formation is unclear. In the present study, we showed that in the presence of the synthetic auxin indole-3-butyric acid (IBA), semi-lignified leafy cuttings from juvenile phase (Mx-J) and rejuvenated (Mx-R) Malus xiaojinensis trees exhibited significantly higher expression of miR156, PIN-FORMED1 (PIN1), PIN10, and rootless concerning crown and seminal roots-like (RTCS-like) genes, thus resulting in higher adventitious rooting ability than those from adult phase (Mx-A) trees...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28674542/physiological-mechanism-of-enhancing-salt-stress-tolerance-of-perennial-ryegrass-by-24-epibrassinolide
#20
Wenli Wu, Qiang Zhang, Erik H Ervin, Zhiping Yang, Xunzhong Zhang
Brassinosteroids (BR) regulate plant tolerance to salt stress but the mechanisms underlying are not fully understood. This study was to investigate physiological mechanisms of 24-epibrassinolide (EBR)'s impact on salt stress tolerance in perennial ryegrass (Lolium perenne L.) The grass seedlings were treated with EBR at 0, 10, and 100 nM, and subjected to salt stress (250 mM NaCl). The grass irrigated with regular water without EBR served as the control. Salt stress increased leaf electrolyte leakage (EL), malondialdehyde (MDA), and reduced photosynthetic rate (Pn)...
2017: Frontiers in Plant Science
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