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https://www.readbyqxmd.com/read/29784955/integration-of-large-scale-data-for-extraction-of-integrated-arabidopsis-root-cell-type-specific-models
#1
Michael Scheunemann, Siobhan M Brady, Zoran Nikoloski
Plant organs consist of multiple cell types that do not operate in isolation, but communicate with each other to maintain proper functions. Here, we extract models specific to three developmental stages of eight root cell types or tissue layers in Arabidopsis thaliana based on a state-of-the-art constraint-based modeling approach with all publicly available transcriptomics and metabolomics data from this system to date. We integrate these models into a multi-cell root model which we investigate with respect to network structure, distribution of fluxes, and concordance to transcriptomics and proteomics data...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29782704/profiling-of-new-psychoactive-substances-nps-by-using-stable-isotope-ratio-mass-spectrometry-irms-study-on-the-synthetic-cannabinoid-5f-pb-22
#2
S Münster-Müller, N Scheid, T Holdermann, S Schneiders, M Pütz
In this paper results of a pilot study on the profiling of the synthetic cannabinoid receptor agonist 5F-PB-22 (5F-QUPIC, pentylfluoro-1H-indole-3-carboxylic acid-8-quinolinyl ester) via isotope ratio mass spectrometry are presented. It is focused on δ13 C, δ15 N and δ2 H isotope ratios, which are determined using elemental analyser (EA) and high temperature elemental analyser (TC/EA) coupled to an isotope ratio mass spectrometer (IRMS). By means of a sample of pure material of 5F-PB-22 it is shown that the extraction of 5F-PB-22 from herbal material, a rapid clean-up procedure, or preparative column chromatography had no influences on the isotope ratios...
May 21, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29778815/photodegradation-of-atrazine-in-the-presence-of-indole-3-acetic-acid-and-natural-montmorillonite-clay-minerals
#3
Lin Zhang, Haoting Tian, Ran Hong, Chao Wang, Yi Wang, Anping Peng, Cheng Gu
Atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) is a commonly used agricultural herbicide that, as a result, is frequently detected in surface and ground water. In this study, we provide evidence of the photo-oxidation of atrazine under environmentally relevant conditions, specifically, in the presence of natural montmorillonite clay and the ubiquitous phytohormone indole-3-acetic acid (IAA). The reaction is initiated by the generation of hydrated electrons from the photo-ionization of IAA. These electrons react with protons and dissolved oxygen to form hydroxyl radicals, which promote the further degradation of atrazine...
May 17, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29777683/probing-the-binding-site-of-novel-selective-positive-allosteric-modulators-at-the-m-1-machr
#4
Elham Khajehali, Celine Valant, Manuela Jörg, Andrew B Tobin, P Jeffrey Conn, Craig W Lindsley, Patrick M Sexton, Peter J Scammells, Arthur Christopoulos
Subtype-selective allosteric modulation of the M1 muscarinic acetylcholine (ACh) receptor (M1 mAChR) is an attractive approach for the treatment of numerous disorders, including cognitive deficits. The discovery of benzyl quinolone carboxylic acid, BQCA, a selective M1 mAChR positive allosteric modulator (PAM), spurred the subsequent development of newer generation M1 PAMs representing diverse chemical scaffolds, different pharmacodynamic properties and, in some instances, improved pharmacokinetics. Key exemplar molecules from such efforts include PF-06767832 (N-((3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl)-5-methyl-4-(4-(thiazol-4-yl)benzyl)pyridine-2-carboxamide), VU6004256 (4,6-difluoro-N-(1S,2S)-2-hydroxycyclohexyl-1-((6-(1-methyl-1H-pyrazol-4-yl)pyridine-3-yl)methyl)-1H-indole-3-carboxamide) and MIPS1780 (3-(2-hydroxycyclohexyl)-6-(2-((4-(1-methyl-1H-pyrazol-4-yl)-benzyl)oxy)phenyl)pyrimidin-4(3H)-one)...
May 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29776387/integrative-genomics-approaches-validate-ppyuc11-like-as-candidate-gene-for-the-stony-hard-trait-in-peach-p-persica-l-batsch
#5
Marco Cirilli, Daniela Giovannini, Angelo Ciacciulli, Remo Chiozzotto, Stefano Gattolin, Laura Rossini, Alessandro Liverani, Daniele Bassi
BACKGROUND: Texture is one of the most important fruit quality attributes. In peach, stony hard (SH) is a recessive monogenic trait (hd/hd) that confers exceptionally prolonged firm flesh to fully ripe fruit. Previous studies have shown that the SH mutation affects the fruit ability to synthesize appropriate amounts of indol-3-acetic acid (IAA), which orchestrates the ripening processes through the activation of system 2 ethylene pathway. Allelic variation in a TC microsatellite located within the first intron of PpYUC11-like (a YUCCA-like auxin-biosynthesis gene) has been recently proposed as the causal mutation of the SH phenotype...
May 18, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29775573/indole-3-carbinol-i3c-enhances-the-sensitivity-of-murine-breast-adenocarcinoma-cells-to-doxorubicin-dox-through-inhibition-of-nf-%C3%AE%C2%BA%C3%AE-blocking-angiogenesis-and-regulation-of-mitochondrial-apoptotic-pathway
#6
Subhadip Hajra, Arup Ranjan Patra, Abhishek Basu, Prosenjit Saha, Sudin Bhattacharya
Various epidemiological and preclinical studies have already established the cancer chemopreventive potential of naturally occurring glucosinolate breakdown product Indole-3-Carbinol (I3C) as well as its abilities to induce selective cell death towards malignant cell. Therefore, the objective of the present study is to improve the therapeutic efficacy and prevention of doxorubicin (DOX)-induced toxicity, by the concurrent use of Indole-3-Carbinol (I3C). In this study, I3C was administered (20 mg/kg b.w., p...
May 15, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29772274/pharmacodynamic-and-pharmacokinetic-characteristics-of-ymr-65-a-tubulin-inhibitor-in-tumor-bearing-mice
#7
Ali Fan, Jiali Wei, Mengru Yang, Qing Zhang, Yaliang Zhang, Qingwang Liu, Ning Li, Di Zhao, Yang Lu, Junxiu Li, Jie Zhao, Shuhua Deng, Bingjie Zhang, Hailiang Zhu, Xijing Chen
YMR-65, 5-(5-bromo-1-methyl-1H-indol-3-yl)-3-(3-methoxyphenyl)-4, 5-dihydro-1H-pyrazole-1-carboxamide, is a potential tubulin inhibitor exhibiting good anticancer activity. In our study, we illustrated the biological activities in HepG2 cells and the pharmacodynamic and pharmacokinetic profiles were evaluated in murine H22 hepatoma-bearing mice. Molecular docking assay and colchicine competition assay indicated that YMR-65 could bind tightly to the colchicine binding site of tubulin. Further investigation demonstrated that YMR-65 arrested cells in the G2/M phase of cell cycle and induced apoptosis in HepG2 cells...
May 14, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29765750/crystal-structures-and-anti-oxidant-capacity-of-e-5-benz-yloxy-2-4-chloro-phen-yl-imino-meth-yl-phenol-and-e-5-benz-yloxy-2-2-1-h-indol-3-yl-eth-yl-iminium-yl-meth-yl-phenolate
#8
Nadir Ghichi, Chawki Bensouici, Ali Benboudiaf, Yacine DJebli, Hocine Merazig
The title Schiff base compounds, C20 H16 ClNO2 (I) and C24 H22 N2 O2 (II), were synthesized via the condensation reaction of 2-amino-4-chloro-phenol for (I), and 2-(2,3-di-hydro-1 H -indol-3-yl)ethan-1-amine for (II), with 4-benz-yloxy-2-hy-droxy-benzaldehyde. In both compounds, the configuration about the C=N imine bond is E . Neither mol-ecule is planar. In (I), the central benzene ring makes dihedral angles of 49.91 (12) and 53.52 (11)° with the outer phenyl and chloro-phenyl rings, respectively. In (II), the central benzene ring makes dihedral angles of 89...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29763306/one-pot-synthesis-of-indole-3-acetic-acid-derivatives-through-cascade-tsuji-trost-reaction-and-heck-coupling
#9
Dongsheng Chen, Yuanyuan Chen, Zhilong Ma, Lei Zou, Jianqi Li, Yu Liu
A practical palladium-mediated cascade Tsuji-Trost reaction/Heck coupling of N-Ts o-bromoanilines with 4-acetoxy-2-butenonic acid derivatives using a Pd(OAc)2/P(o-tol)3/DIPEA system is described for a straightforward synthesis of indole-3-acetic acid derivatives. This methodology was successfully applied to synthesize various substituted indole/azaindole-3-acetic acid derivatives and Almotriptan, which is a drug for the acute treatment of migraine. Moreover, a plausible cyclization mechanism has been proposed...
May 15, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29758473/genome-wide-analysis-of-poplar-saur-gene-family-and-expression-profiles-under-cold-polyethylene-glycol-and-indole-3-acetic-acid-treatments
#10
Wenfang Hu, Hanwei Yan, Shuangshuang Luo, Feng Pan, Yue Wang, Yan Xiang
Small auxin-up RNA (SAUR) proteins play an important role in the regulation of plant growth and development. Here, we identified 105 SAUR genes and comprehensively analyzed them in Populus trichocarpa. Based on the phylogenetic relationships, the PtSAURs were classified into ten subfamilies. Of the 105 PtSAURs, 100 were randomly distributed along the nineteen chromosomes, while the remaining genes were located along unassigned scafoolds. These genes mainly evolved through segmental duplications. In total, 94 PtSAURs contained no introns, and each group had a similar conserved motif structure...
May 8, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29755501/enhanced-conjugation-of-auxin-by-gh3-enzymes-leads-to-poor-adventitious-rooting-in-carnation-stem-cuttings
#11
Antonio Cano, Ana Belén Sánchez-García, Alfonso Albacete, Rebeca González-Bayón, María Salud Justamante, Sergio Ibáñez, Manuel Acosta, José Manuel Pérez-Pérez
Commercial carnation ( Dianthus caryophyllus ) cultivars are vegetatively propagated from axillary stem cuttings through adventitious rooting; a process which is affected by complex interactions between nutrient and hormone levels and is strongly genotype-dependent. To deepen our understanding of the regulatory events controlling this process, we performed a comparative study of adventitious root (AR) formation in two carnation cultivars with contrasting rooting performance, "2101-02 MFR" and "2003 R 8", as well as in the reference cultivar "Master"...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29755493/dynamic-modeling-of-indole-glucosinolate-hydrolysis-and-its-impact-on-auxin-signaling
#12
Daniel Vik, Namiko Mitarai, Nikolai Wulff, Barbara A Halkier, Meike Burow
Plants release chemicals to deter attackers. Arabidopsis thaliana relies on multiple defense compounds, including indol-3-ylmethyl glucosinolate (I3G), which upon hydrolysis initiated by myrosinase enzymes releases a multitude of bioactive compounds, among others, indole-3-acetonitrile and indole-3-acetoisothiocyanate. The highly unstable isothiocyanate rapidly reacts with other molecules. One of the products, indole-3-carbinol, was reported to inhibit auxin signaling through binding to the TIR1 auxin receptor...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29752087/preparation-and-characterization-of-indole-3-butyric-acid-nanospheres-for-improving-its-stability-and-utilization
#13
Hongqiang Dong, Mingcheng Guo, You Liang, Chen Fan, Guanglong Ding, Wenbing Zhang, Gang Tang, Jiale Yang, Dandan Kong, Yongsong Cao
Indole-3-butyric acid (IBA) is an efficient plant growth regulator for promoting germination and the formation of rooting of various plants. Since it is unstable and presents the low utilization ratio, there is a compelling need to design an environmentally friendly formulation for IBA, which can reduce the loss of degradation and improve its utilization. Nano-sized controlled-release formulations can provide better durability and penetrate through the plant epidermis to efficiently deliver the agrochemicals to the target tissues...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29751062/new-insights-into-auxin-metabolism-in-bradyrhizobium-japonicum
#14
Daniela Torres, Iliana Benavidez, Florencia Donadio, Elias Mongiardini, Susana Rosas, Stijn Spaepen, Jozef Vanderleyden, Aleš Pěnčík, Ondřej Novák, Miroslav Strnad, Jitka Frébortová, Fabricio Cassán
Bacterial metabolism of phytohormones includes several processes such as biosynthesis, catabolism, conjugation, hydrolysis and homeostatic regulation. However, only biosynthesis and occasionally catabolism are studied in depth in microorganisms. In this work, we evaluated and reconsidered IAA metabolism in B. japonicum E109, one of the most widely used strains for soybean inoculation around the world. The genomic analysis of the strain showed the presence of several genes responsible for IAA biosynthesis, mainly via indole-3-acetonitrile (IAN), indole-3-acetamide (IAM) and tryptamine (TAM) pathways...
May 8, 2018: Research in Microbiology
https://www.readbyqxmd.com/read/29749087/nuclear-factor-erythroid-derived-2-related-factor-2-activates-glutathione-s-transferase-expression-in-the-midgut-of-spodoptera-litura-lepidoptera-noctuidae-in-response-to-phytochemicals-and-insecticides
#15
S Chen, M Lu, N Zhang, X Zou, M Mo, S Zheng
Detoxication enzymes play an important role in insect resistance to xenobiotics such as insecticides and phytochemicals. We studied the pathway for activating the expression of glutathione S-transferases (GSTs) in response to selected xenobiotics. An assay of the promoter activity of GST epsilon 1 (Slgste1) of Spodoptera litura led to the discovery of a cis-regulating element. An antioxidant response element was activated in response to indole-3-carbinol (I3C) and chlorpyrifos (CPF) and was able to bind with the xenobiotic sensor protein nuclear factor erythroid-derived 2-related factor 2 (SlNrf2)...
May 10, 2018: Insect Molecular Biology
https://www.readbyqxmd.com/read/29746934/indole-3-carbinol-induces-apoptosis-in-human-hepatocellular-carcinoma-huh-7-cells
#16
Chang Min Lee, Yong Jun Choi, See-Hyoung Park, Myeong Jin Nam
No abstract text is available yet for this article.
May 7, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29746094/an-engineered-device-for-indoleacetic-acid-production-under-quorum-sensing-signals-enables-cupriavidus-pinatubonensis-jmp134-to-stimulate-plant-growth
#17
Ana Zuniga, Francisco De la Fuente, Fernan Federici, Corinne Lionne, Jerome Bonnet, Victor de Lorenzo, Bernardo Gonzalez
The environmental effects of chemical fertilizers and pesticides have encouraged the quest for new strategies to increase crop productivity with minimal impacts on the natural medium. Plant growth promoting rhizobacteria (PGPR) can contribute to this endeavor by improving fitness through better nutrition acquisition and stress tolerance. Using the neutral (non PGPR) rhizobacterium Cupriavidus pinatubonensis JMP134 as the host, we engineered a regulatory forward loop that triggered the synthesis of the phytohormone indole-3-acetic acid (IAA) in a manner dependent on quorum sensing (QS) signals...
May 10, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29743856/current-results-on-the-biological-and-pharmacological-activities-of-indole-3-carbinol
#18
Jae Kwang Kim, Sang Un Park
No abstract text is available yet for this article.
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29739966/proteomic-analysis-reveals-that-auxin-homeostasis-influences-the-eighth-internode-length-heterosis-in-maize-zea-mays
#19
Yongqiang Chen, Qingqian Zhou, Runmiao Tian, Zhihui Ma, Xiaofeng Zhao, Jihua Tang, Zhiyuan Fu
Ear height is an important maize morphological trait that influences plant lodging resistance in the field, and is based on the number and length of internodes under the ear. To explore the effect of internodes on ear height, the internodes under the ear were analysed in four commercial hybrids (Jinsai6850, Zhengdan958, Xundan20, and Yuyu22) from different heterotic groups in China. The eighth internode, which is the third aboveground extended internode, exhibited high-parent or over high-parent heterosis and contributed considerably to ear height...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739310/genetic-diversity-and-characterization-of-arsenic-resistant-endophytic-bacteria-isolated-from-pteris-vittata-an-arsenic-hyperaccumulator
#20
Yunfu Gu, Yingyan Wang, Yihao Sun, Ke Zhao, Quanju Xiang, Xiumei Yu, Xiaoping Zhang, Qiang Chen
BACKGROUND: Alleviating arsenic (As) contamination is a high-priority environmental issue. Hyperaccumulator plants may harbor endophytic bacteria able to detoxify As. Therefore, we investigated the distribution, diversity, As (III) resistance levels, and resistance-related functional genes of arsenite-resistant bacterial endophytes in Pteris vittata L. growing in a lead-zinc mining area with different As contamination levels. RESULTS: A total of 116 arsenite-resistant bacteria were isolated from roots of P...
May 8, 2018: BMC Microbiology
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