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Indole-3

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https://www.readbyqxmd.com/read/28528271/exploring-binding-characteristics-and-the-related-competition-of-different-protein-bound-uremic-toxins
#1
Olivier Deltombe, Henriette de Loor, Griet Glorieux, Annemieke Dhondt, Wim Van Biesen, Björn Meijers, Sunny Eloot
Little is known about potential differences in binding characteristics of protein-bound uremic toxins (PBUTs) in patients with chronic kidney disease (CKD) versus healthy controls. The question arises whether eventual differences are attributed to (i) the elevated levels of competing uremic toxins, and/or (ii) post-translational modifications of albumin. We evaluated the binding characteristics of hippuric acid (HA), indole-3-acetic acid (IAA), indoxyl sulfate (IS), and p-cresylsulfate (pCS) by deriving a binding curve in three distinct conditions: (i) serum from healthy controls (healthy serum), (ii) blank serum from hemodialysis patients (blank HD serum; i...
May 17, 2017: Biochimie
https://www.readbyqxmd.com/read/28526982/pre-drought-priming-sustains-grain-development-under-post-anthesis-drought-stress-by-regulating-the-growth-hormones-in-winter-wheat-triticum-aestivum-l
#2
Muhammad Abid, Yuhang Shao, Sixi Liu, Feng Wang, Jingwen Gao, Dong Jiang, Zhongwei Tian, Tingbo Dai
Drought stress during grain filling is the most yield-damaging to wheat. Pre-drought priming facilitated the wheat plants to sustain grain development against the post-anthesis drought stress by modulating the levels of growth hormones. Post-anthesis drought stress substantially reduces grain yield in wheat (Triticum aestivum L.) due to impaired grain development associated with imbalanced levels of growth hormones. To investigate whether pre-drought priming could sustain grain development in wheat by regulating favorable levels of growth hormones under post-anthesis drought conditions, the plants of a drought-sensitive (Yangmai-16) and drought-tolerant (Luhan-7) wheat cultivar were exposed to a moderate drought stress during tillering (Feekes 2 stage) for priming, and then, a subsequent severe drought stress was applied from 7 to 14 days after anthesis...
May 19, 2017: Planta
https://www.readbyqxmd.com/read/28525842/indole-coumarin-thiadiazole-hybrids-an-appraisal-of-their-mcf-7%C3%A2-cell-growth-inhibition-apoptotic-antimetastatic-and-computational-bcl-2-binding-potential
#3
Pooja R Kamath, Dhanya Sunil, Manu M Joseph, Abdul Ajees Abdul Salam, Sreelekha T T
Cancer therapeutic potential of thiadiazole hybrids incorporating pharmacologically active indole and coumarin moieties have not been explored much. In the current investigation, three new thiadiazole hybrids with spacers of varying lengths linking indole and thiadiazole units were synthesized and their structures were well-established using various spectroscopic techniques. 3-(1-(5-(3-(1H-indol-3-yl)propyl)-1,3,4-thiadiazol-2-ylimino)ethyl)-6-bromo-2H-chromen-2-one (IPTBC) exhibited dose-dependent cytotoxicity in breast adenocarcinoma (MCF-7) cells...
May 11, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28525840/indole-carboxylic-acid-esters-of-melampomagnolide-b-are-potent-anticancer-agents-against-both-hematological-and-solid-tumor-cells
#4
Shobanbabu Bommagani, Jessica Ponder, Narsimha R Penthala, Venumadhav Janganati, Craig T Jordan, Michael J Borrelli, Peter A Crooks
A series of novel, heteroaryl carboxylic acid conjugates of the sesquiterpene melampomagnolide-B (MMB, 3) has been evaluated as antitumor agents against an NCI panel of 64 human hematopoetic and solid tumor cell lines. The indole-3-acrylic acid conjugate 7j and the indole-3-carboxylic acid conjugate 7k were found to be the most potent analogs in the series. Compounds 7j and 7k exhibited remarkable growth inhibition, with GI50 values in the range 0.03-0.30 μM and 0.04-0.28 μM, respectively, against the cell lines in the leukemia sub-panel, and GI50 values of 0...
May 11, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28525356/synthesis-biological-activity-and-molecular-modeling-study-of-new-schiff-bases-incorporated-with-indole-moiety
#5
Ahmed H Halawa, Shimaa Mohamed Abd El-Gilil, Ahmed H Bedair, Mohamed Shaaban, Marcel Frese, Norbert Sewald, Essam M Eliwa, Ahmed M El-Agrody
A new series of heterocyclic Schiff bases 2-9 containing indole moiety were synthesized by facile and efficient condensation of indole-3/2/5-carboxaldehyde (1a/1b/1c) with different aromatic and heterocyclic primary amines using conventional and/or microwave irradiation methods. The structures of the obtained compounds were assigned by sophisticated spectroscopic and spectrometric techniques (1D-NMR, 2D-NMR and MS). The synthesized compounds were screened for their cytotoxicity and antibacterial activities...
May 18, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28512461/transcriptional-responses-to-pre-flowering-leaf-defoliation-in-grapevine-berry-from-different-growing-sites-years-and-genotypes
#6
Sara Zenoni, Silvia Dal Santo, Giovanni B Tornielli, Erica D'Incà, Ilaria Filippetti, Chiara Pastore, Gianluca Allegro, Oriana Silvestroni, Vania Lanari, Antonino Pisciotta, Rosario Di Lorenzo, Alberto Palliotti, Sergio Tombesi, Matteo Gatti, Stefano Poni
Leaf removal is a grapevine canopy management technique widely used to modify the source-sink balance and/or microclimate around berry clusters to optimize fruit composition. In general, the removal of basal leaves before flowering reduces fruit set, hence achieving looser clusters, and improves grape composition since yield is generally curtailed more than proportionally to leaf area itself. Albeit responses to this practice seem quite consistent, overall vine performance is affected by genotype, environmental conditions, and severity of treatment...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28508231/role-of-the-aryl-hydrocarbon-receptor-in-carcinogenesis-and-potential-as-an-anti-cancer-drug-target
#7
REVIEW
Siva Kumar Kolluri, Un-Ho Jin, Stephen Safe
The aryl hydrocarbon receptor (AhR) was initially identified as the receptor that binds and mediates the toxic effects induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and structurally related halogenated aromatics. Other toxic compounds including some polynuclear aromatic hydrocarbons act through the AhR; however, during the last 25 years, it has become apparent that the AhR plays an essential role in maintaining cellular homeostasis. Moreover, the scope of ligands that bind the AhR includes endogenous compounds such as multiple tryptophan metabolites, other endogenous biochemicals, pharmaceuticals and health-promoting phytochemicals including flavonoids, indole-3-carbinol and its metabolites...
May 15, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28501532/targeted-inhibition-of-klotho-binding-to-fibroblast-growth-factor-23-prevents-hypophosphetemia
#8
Muhammad Fakhar, Sajid Rashid
Klotho is a transmembrane protein which plays significant role in the pathogenesis of phosphate ion (Pi)-related disorders. Pi accumulation in human kidney tissues results in the major metabolic disorders due to malfunctioning of Klotho-FGFR1-FGF23 trimeric complex. The potential role of Klotho in Pi metabolism was elaborated through modeling and interaction analysis of glycosyl hydrolase (GS1 and GS2) domains with Fibroblast growth factor 23 (FGF23). In order to inhibit the association of Klotho and FGF23, binding patterns of three reported hits (N-(2-chlorophenyl)-1H-indole-3-carboxamide, N-[2-(1-cyclohexen-1-yl)ethyl]-6,7,8,9-tetrahydropyrido[1,2-e]purin-4-amine and 2-(1-propyl)amino-11-chlorothiazolo[5,4-a]acridine) were evaluated through molecular docking analysis...
April 27, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28501148/simultaneous-determination-of-acidic-phytohormones-in-cucumbers-and-green-bean-sprouts-by-ion-pair-stir-bar-sorptive-extraction-high-performance-liquid-chromatography
#9
Wei Wang, Man He, Beibei Chen, Bin Hu
A simple, sensitive and inexpensive method of ion-pair stir bar sorptive extraction (IP-SBSE) combined with high performance liquid chromatography -ultraviolet (HPLC-UV) detection was developed for the simultaneous determination of three acidic phytohormones (salicylic acid (SA), indole-3-acetic acid (IAA), and abscisic acid (ABA)) in vegetables. With the addition of cationic surfactant-cetyltrimethylammonium bromide (CTAB) in sample solutions, ion pair between CTAB and target phytohormones were formed, leading to an improvement of the extraction efficiency for target phytohormones by C18 silica coated SBSE...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28499078/genome-wide-analysis-of-the-lateral-organ-boundaries-domain-lbd-gene-family-in-eucalyptus-grandis-reveals-members-that-differentially-impact-secondary-growth
#10
Qiang Lu, Fenjuan Shao, Colleen Macmillan, Iain W Wilson, Karen van der Merwe, Steven G Hussey, Alexander A Myburg, Xiaomei Dong, Deyou Qiu
Lateral Organ Boundaries Domain (LBD) proteins are plant-specific transcription factors playing crucial roles in growth and development. However, the function of LBD proteins in Eucalyptus grandis remains largely unexplored. In the present study, LBD genes in E. grandis were identified and characterized using bioinformatics approaches. Gene expression patterns in various tissues and the transcriptional responses of EgLBDs to exogenous hormones were determined by qRT-PCR. Functions of the selected EgLBDs were studied by ectopically overexpressing in a hybrid poplar (Populus alba × Populus glandulosa)...
May 12, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28498348/nutrients-turned-into-toxins-microbiota-modulation-of-nutrient-properties-in-chronic-kidney-disease
#11
REVIEW
Raul Fernandez-Prado, Raquel Esteras, Maria Vanessa Perez-Gomez, Carolina Gracia-Iguacel, Emilio Gonzalez-Parra, Ana B Sanz, Alberto Ortiz, Maria Dolores Sanchez-Niño
In chronic kidney disease (CKD), accumulation of uremic toxins is associated with an increased risk of death. Some uremic toxins are ingested with the diet, such as phosphate and star fruit-derived caramboxin. Others result from nutrient processing by gut microbiota, yielding precursors of uremic toxins or uremic toxins themselves. These nutrients include l-carnitine, choline/phosphatidylcholine, tryptophan and tyrosine, which are also sold over-the-counter as nutritional supplements. Physicians and patients alike should be aware that, in CKD patients, the use of these supplements may lead to potentially toxic effects...
May 12, 2017: Nutrients
https://www.readbyqxmd.com/read/28496135/isolated-bacillus-subtilis-strain-330-2-and-its-antagonistic-genes-identified-by-the-removing-pcr
#12
Zahoor Ahmad, Jia Wu, Lulu Chen, Wubei Dong
Plant growth-promoting bacteria (PGPB) may trigger tolerance against biotic/abiotic stresses and growth enhancement in plants. In this study, an endophytic bacterial strain from rapeseed was isolated to assess its role in enhancing plant growth and tolerance to abiotic stresses, as well as banded leaf and sheath blight disease in maize. Based on 16S rDNA and BIOLOG test analysis, the 330-2 strain was identified as Bacillus subtilis. The strain produced indole-3-acetic acid, siderophores, lytic enzymes and solubilized different sources of organic/inorganic phosphates and zinc...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28487539/mapk-mediated-auxin-signal-transduction-pathways-regulate-the-malic-acid-secretion-under-aluminum-stress-in-wheat-triticum-aestivum-l
#13
Xinwei Liu, Yameng Lin, Diqiu Liu, Chengxiao Wang, Zhuqing Zhao, Xiuming Cui, Ying Liu, Ye Yang
An isobaric tags for relative and absolute quantitative (iTRAQ)-based quantitative proteomic approach was used to screen the differentially expressed proteins during control treatment (CK), aluminum (Al) and Al(+) indole-3-acetic acid (IAA) treatment of wheat lines ET8 (Al-tolerant). Further, the the expression levels of auxin response factor (ARF), Aux/IAA, Mitogen activated protein kinase (MAPK) 2c, and MAPK1a were analyzed. Results showed that 16 proteins were determined to be differentially expressed in response to Al and IAA co-treatment compared with Al alone...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28481096/cuo-and-zno-nanoparticles-modify-interkingdom-cell-signaling-processes-relevant-to-crop-production-a-review
#14
Anne Anderson, Joan E McLean, Astrid Rosa Jacobson, David Britt
As the world population increases, strategies for sustainable agriculture are needed to fulfill the global need for plants for food and other commercial products. Nanoparticle formulations are likely to be part of the developing strategies. CuO and ZnO nanoparticles (NPs) offer potential as fertilizers, as they provide bioavailable essential metals, and as pesticides, because of dose-dependent toxicity. Effects of these metal oxide NPs on rhizosphere functions are the focus of this review. These NPs at doses of 10 mg metal/kg and above change production of key metabolites involved in plant protection in a root-associated microbe, Pseudomonas chlororaphis O6...
May 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28480489/effect-of-microorganisms-on-reducing-cadmium-uptake-and-toxicity-in-rice-oryza-sativa-l
#15
Chairat Treesubsuntorn, Prapai Dhurakit, Gholamreza Khaksar, Paitip Thiravetyan
This study analyzed the application of three microorganism inoculums, including Bacillus subtilis, Bacillus cereus, and commercial effective microorganism (EM) solution in order to determine cadmium (Cd) reduction in rice (Oryza sativa L.) and rice growth promotion. Rice was grown in Cd-contaminated soil (120 mg/kg) and selected microorganisms were inoculated. Cd concentration and rice weight were measured at 45 and 120 days of the experiment. The result showed that B. subtilis inoculation into rice can highly reduce Cd accumulation in every part of rice roots and shoots (45 days), and grains (120 days)...
May 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28476147/genome-wide-analysis-and-characterization-of-aux-iaa-family-genes-related-to-fruit-ripening-in-papaya-carica-papaya-l
#16
Kaidong Liu, Changchun Yuan, Shaoxian Feng, Shuting Zhong, Haili Li, Jundi Zhong, Chenjia Shen, Jinxiang Liu
BACKGROUND: Auxin/indole-3-acetic acid (Aux/IAA) family genes encode short-lived nuclear proteins that mediate the responses of auxin-related genes and are involved in several plant developmental and growth processes. However, how Aux/IAA genes function in the fruit development and ripening of papaya (Carica papaya L.) is largely unknown. RESULTS: In this study, a comprehensive identification and a distinctive expression analysis of 18 C. papaya Aux/IAA (CpIAA) genes were performed using newly updated papaya reference genome data...
May 5, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28471010/oxidative-n-heterocyclic-carbene-catalyzed-dearomatization-of-indoles-to-spirocyclic-indolenines-with-a-quaternary-carbon-stereocenter
#17
Srikrishna Bera, Constantin G Daniliuc, Armido Studer
An efficient method for the asymmetric intramolecular dearomatization of indoles by using oxidative N-heterocyclic carbene catalysis is demonstrated. Valuable optically active spirocyclic indolenines bearing an all-carbon quaternary stereocenter are obtained in excellent yields and with excellent enantioselectivity. The starting indoles are readily prepared and the reactions proceed through an intramolecular indole 3-acylation with an in situ generated acyl azolium intermediate to form a spirocyclic ketone moiety...
May 4, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28467152/the-interaction-between-glucose-and-cytokinin-signaling-in-controlling-arabidopsis-thaliana-seedling-root-growth-and-development
#18
Sunita Kushwah, Ashverya Laxmi
Cytokinin (CK) and glucose (GLC) control several common responses in plants. There is an extensive overlap between CK and GLC signal transduction pathways in Arabidopsis. Physiologically, both GLC and CK could regulate root length in light. CK interacts with GLC via HXK1 dependent pathway for root length control. Wild-type (WT) roots cannot elongate in the GLC free medium while CK-receptor mutant ARABIDOPSIS HISTIDINE KINASE4 (ahk4) and type B ARR triple mutant ARABIDOPSIS RESPONSE REGULATOR1, 10,11 (arr1, 10,11) roots could elongate even in the absence of GLC as compared with the WT...
May 3, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28464374/palladium-catalyzed-regioselective-synthesis-of-3-arylindoles-from-n-ts-anilines-and-styrenes
#19
So Won Youn, Tae Yun Ko, Young Ho Jang
A Pd-catalyzed intermolecular oxidative annulation between N-Ts-anilines and styrenes was developed. This method offers a straightforward and robust approach to a wide range of 3-arylindoles using readily available starting materials with good functional-group tolerance and high regioselectivity and efficiency. Further elaboration of the products obtained from this process provided access to highly functionalized and structurally diverse indoles, for example, 3-(indol-3-yl)carbazoles, 1,9-dihydropyrrolo-[2,3-b]carbazoles, and 3'-aryl-3,5'-biindoles...
May 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28459610/3-3-diindolylmethane-suppresses-adipogenesis-using-ampk%C3%AE-dependent-mechanism-in-3t3-l1-adipocytes-and-caenorhabditis-elegans
#20
Jihye Lee, Yiren Yue, Yeonhwa Park, Seong-Ho Lee
3,3'-diindolylmethane is a major in vivo metabolite of indole-3-carbinol, a bioactive compound found in cruciferous vegetables. Although 3,3'-diindolylmethane has been implicated to possess antitumorigenic and anti-inflammatory properties, the effect of 3,3'-diindolylmethane on adipogenesis has not been explored previously. Thus, the present study was conducted to determine if 3,3'-diindolylmethane affects adipogenesis using 3T3-L1 adipocytes and Caenorhabditis elegans. Treatment of 3,3'-diindolylmethane significantly reduced fat accumulation without affecting viability in 3T3-L1 adipocytes...
May 1, 2017: Journal of Medicinal Food
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