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https://www.readbyqxmd.com/read/28644407/cotton-ascorbate-oxidase-promotes-cell-growth-in-cultured-tobacco-bright-yellow-2-cells-through-generation-of-apoplast-oxidation
#1
Rong Li, Shan Xin, Chengcheng Tao, Xiang Jin, Hongbin Li
Ascorbate oxidase (AO) plays an important role in cell growth through the modulation of reduction/oxidation (redox) control of the apoplast. Here, a cotton (Gossypium hirsutum) apoplastic ascorbate oxidase gene (GhAO1) was obtained from fast elongating fiber tissues. GhAO1 belongs to the multicopper oxidase (MCO) family and includes a signal peptide and several transmembrane regions. Analyses of quantitative real-time polymerase chain reaction (QRT-PCR) and enzyme activity showed that GhAO1 was expressed abundantly in 15-day post-anthesis (dpa) wild-type (WT) fibers in comparison with fuzzless-lintless (fl) mutant ovules...
June 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28639414/brachiaria-grasses-brachiaria-spp-harbor-a-diverse-bacterial-community-with-multiple-attributes-beneficial-to-plant-growth-and-development
#2
Collins Mutai, Joyce Njuguna, Sita Ghimire
Endophytic and plant-associated bacteria were isolated from plants and rhizoplane soil of naturally grown Brachiaria grasses at International Livestock Research Institute in Nairobi, Kenya. Eighty-four bacterial strains were isolated from leaf tissues, root tissues, and rhizoplane soil on nutrient agar and 869 media. All bacterial strains were identified to the lowest possible taxonomic unit using 16S rDNA primers and were characterized for the production of Indole-3-acetic acid, hydrogen cyanide, and ACC deaminase; phosphate solubilization; siderophore production; antifungal properties; and plant biomass production...
June 21, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28631564/indole-3-carbinol-induces-apoptosis-of-chronic-myelogenous-leukemia-cells-through-suppression-of-stat5-and-akt-signaling-pathways
#3
Majid Safa, Leila Jafari, Fatemeh Alikarami, Rima Manafi Shabestari, Ahmad Kazemi
Signal transducer and activator of transcription 5 and Akt pathways, implicated in signaling transduction downstream of BCR-ABL, play critical roles in the pathogenesis of chronic myeloid leukemia. Therefore, idenication of novel compounds that modulate the activity of such pathways could be a new approach in the treatment of chronic myeloid leukemia. Previous studies have demonstrated that indole-3-carbinol inhibits the proliferation and induces apoptosis of various tumor cells. However, its anticancer activity against chronic myeloid leukemia cells and the underlying mechanism remain unclear...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28628926/synthesis-characterisation-molecular-docking-anti-microbial-and-anti-diabetic-screening-of-substituted-4-indolylphenyl-6-arylpyrimidine-2-imine-derivatives
#4
Veerasamy Ramya, Santhirakasu Vembu, Ganesan Ariharasivakumar, Manathusamy Gopalakrishnan
The purpose of the research is to synthesise a novel series of (E)-2-(4-(1H-indol-3-yl)-6-p-substituted phenylpyrimidin-2-yl)dimethylguanidine derivatives since 3-(1H-indol-3-yl)-1-p-substituted phenylprop-2-en-1-one and evaluate their molecular docking studies, antimicrobial, and anti-diabetic activities. Among all the synthesized compounds (11a-g), compound 11a exhibits excellent CDOCKER energy (-11.36 kcal/mol). The entire compounds (11a-g) confirm very good antimicrobial activity towards the tested microorganisms...
June 19, 2017: Drug Research
https://www.readbyqxmd.com/read/28625094/a-new-indole-alkaloid-from-the-traditional-chinese-medicine-chansu
#5
Ying-Hui Dai, An-Dong Wang, Yu-Lin Chen, Ming-Yu Xia, Xin-Yi Shao, Dong-Chun Liu, Dong Wang
A new indole alkaloid N'-formylserotonin (1), along with five known indole alkaloids N'-methylserotonin (2), 5-hydroxy-1H-indole-3-carbaldehyde (3), N-acetylserotonin (4), 6-hydroxy-1-oxo-3,4-dihydro-β-carboline (5), and bufoserotoin C (6), were isolated from the water extract of traditional Chinese medicine Chansu. Their structures were elucidated on the basis of spectral analyses. The cytotoxicities of 1-6 against human lung adenocarcinoma epithelial cells A549 were tested using the MTT method. Compound 6 exhibited stronger cytotoxic effect than 5-FU, and 1-5 showed no cytotoxic effects...
June 19, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28621915/wounding-of-arabidopsis-leaves-induces-indole-3-carbinol-dependent-autophagy-in-roots-of-arabidopsis-thaliana
#6
Ella Katz, Daniel A Chamovitz
In cruciferous plants, insect attack or physical damage induce the synthesis of the glucosinolate breakdown product indole-3-carbinol, which plays a key role in the defense against attackers. Indole-3-carbinol also affects plant growth and development by acting as an auxin antagonist by binding to the TIR1 auxin receptor. Other potential functions of indole-3-carbinol and the underlying mechanisms in plant biology are unknown. Here we show that an indole-3-carbinol-dependent signal induces specific autophagy in root cells...
June 16, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28620003/correction-indole-3-carbinol-synergizes-with-and-restores-fludarabine-sensitivity-in-chronic-lymphocytic-leukemia-cells-irrespective-of-p53-activity-and-treatment-resistances
#7
(no author information available yet)
No abstract text is available yet for this article.
June 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28619389/the-promising-effect-of-linagliptin-and-or-indole-3-carbinol-on-experimentally-induced-polycystic-ovarian-syndrome-the-role-of-transforming-growth-factor-beta-1-oxidative-stress-and-nrf2-ho-1-pathway
#8
Ahmed M Kabel, Aisha H Al-Shehri, Rehab A Altalhi
Polycystic ovarian syndrome (PCOS) is one of the most common medical condition that leads to female infertility worldwide. The aim of this study was to assess the effect of linagliptin and/or indole-3-carbinol (I3C) on PCOS in female rats. Fifty female Wistar rats were randomly allocated into five equal groups: Control group; Letrozole induced PCOS group; Letrozole + Linagliptin group; Letrozole + I3C group and Letrozole + Linagliptin + I3C group. Body weight, body mass index, Lee index and ovarian indices were determined...
June 12, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28611799/endophytic-paecilomyces-formosus-lhl10-augments-glycine-max-l-adaptation-to-ni-contamination-through-affecting-endogenous-phytohormones-and-oxidative-stress
#9
Saqib Bilal, Abdul L Khan, Raheem Shahzad, Sajjad Asaf, Sang-Mo Kang, In-Jung Lee
This study investigated the Ni-removal efficiency of phytohormone-producing endophytic fungi Penicillium janthinellum, Paecilomyces formosus, Exophiala sp., and Preussia sp. Among four different endophytes, P. formosus LHL10 was able to tolerate up to 1 mM Ni in contaminated media as compared to copper and cadmium. P. formosus LHL10 was further assessed for its potential to enhance the phytoremediation of Glycine max (soybean) in response to dose-dependent increases in soil Ni (0.5, 1.0, and 5.0 mM). Inoculation with P...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28609100/fiaud-s-acid-a-br%C3%A3-nsted-acid-catalyst-for-enantioselective-friedel-crafts-alkylation-of-indoles-with-2-alkene-1-4-diones
#10
Sourav Chatterjee, Lukas Hintermann, Madhumita Mandal, Anushree Achari, Sreya Gupta, Parasuraman Jaisankar
Fiaud's acid (trans-1-hydroxy-2,5-diphenylphospholane 1-oxide), a phospholane-based phosphinic acid, is introduced as an efficient chiral Brønsted acid catalyst that mediates the asymmetric Friedel-Crafts alkylation of indoles with 2-butene-1,4-diones. With a catalyst loading of 10 mol %, the reaction proceeded smoothly to afford 2-(indol-3-yl)butane-1,4-diones in high yield (up to 82%) and high enantioselectivity (up to 91% ee, one such product showed enhanced ee of 98% after recrystallization). The reaction conditions are sufficiently mild to tolerate sensitive functionality at room temperature and are therefore suitable for the synthesis of complex targets...
June 13, 2017: Organic Letters
https://www.readbyqxmd.com/read/28596013/two-likely-targets-for-the-anti-cancer-effect-of-indole-derivatives-from-cruciferous-vegetables-pi3k-akt-mtor-signalling-pathway-and-the-aryl-hydrocarbon-receptor
#11
REVIEW
Ada Popolo, Aldo Pinto, Maria Daglia, Seyed Fazel Nabavi, Ammad Ahmad Farooqi, Luca Rastrelli
Diets containing high quantities of plant foods are linked with a decreased likelihood of incidence of cancer. Several common plant-based dietary components exert effects on DNA methylation levels, and can positively influence genome stability and the transcription of tumor suppressors and oncogenes. Indole-3-carbinol (I3C) is a substance present in vegetables of the Brassicaeae family, especially broccoli, white cabbage, Brussels sprouts and cauliflower. The in vivo biological effects of I3C are ascribed to a series of oligomeric products (including 3,3'-diindolylmethane), developed under acidic conditions...
June 5, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28588600/date-palm-tree-phoenix-dactylifera-l-natural-products-and-therapeutic-options
#12
REVIEW
Reem A Al-Alawi, Jawhara H Al-Mashiqri, Jawaher S M Al-Nadabi, Badria I Al-Shihi, Younis Baqi
Many plants, including some of the commonly consumed herbs and spices in our daily food, can be safely and effectively used to prevent and/or treat some health concerns. For example, caffeine the active ingredient found in coffee beans (Coffea), shows biological activity in the treatment of the central nervous system (CNS) disorders, indole-3-carbinol, and 3,3'-diindolylmethane are both broccoli (Brassica oleracea) derived phytochemicals with potential anti-cancer activity, and resveratrol, isolated from grape (Vitis vinifera), is reported to extend lifespan and provide cardio-neuro-protective, anti-diabetic, and anti-cancer effects...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28586721/antibacterial-and-antibiofilm-activities-of-the-metabolites-isolated-from-the-culture-of-the-mangrove-derived-endophytic-fungus-eurotium-chevalieri-kufa-0006
#13
War War May Zin, Suradet Buttachon, Tida Dethoup, José A Pereira, Luís Gales, Ângela Inácio, Paulo M Costa, Michael Lee, Nazim Sekeroglu, Artur M S Silva, Madalena M M Pinto, Anake Kijjoa
Five previously undescribed metabolites, including acetylquestinol, two prenylated indole 3-carbaldehyde derivatives, an anthranilic acid derivative and an isochromone derivative, were isolated, in addition to eleven known compounds: palmitic acid, ergosterol 5,8-endoperoxide, emodin, physcion, questin, questinol, (11S, 14R)-cyclo(tryptophylvalyl), preechinulin, neoechinulin E, echinulin and eurocristatine, from the culture of the endophytic fungus Eurotium chevalieri KUFA 0006. The structures of the previously undescribed compounds were established based on an extensive 1D and 2D NMR spectral analysis as well as HRMS and IR data...
June 3, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28586165/3-3-diindolylmethane-suppresses-high-fat-diet-induced-obesity-through-inhibiting-adipogenesis-of-pre-adipocytes-by-targeting-usp2-activity
#14
Hee Yang, Sang Gwon Seo, Seung Ho Shin, Soyun Min, Min Jeong Kang, Ra Yoo, Jeong Yeon Kwon, Shuhua Yue, Kee Hong Kim, Ji-Xin Cheng, Jong Rhan Kim, Jun Suk Park, Jong Hun Kim, Jung Han Yoon Park, Hyong Joo Lee, Ki Won Lee
SCOPE: Indole-3-carbinol (I3C), a derivative abundant in cruciferous vegetables such as cabbage, is well known for its various health benefits such as chemo-preventive and anti-obesity effects. I3C is easily metabolized to 3,3'-diindolylmethane (DIM), a more stable form, in acidic conditions of the stomach. However, the anti-obesity effect of DIM has not been investigated clearly. We sought to investigate the effect of DIM on diet-induced obesity and to elucidate its underlying mechanisms...
June 6, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28586058/3-3-diindolylmethane-downregulates-cyclin%C3%A2-d1-through-triggering-endoplasmic-reticulum-stress-in-colorectal-cancer-cells
#15
Xiaobo Zhang, Pakin Sukamporn, Shiqiang Zhang, Kyung-Won Min, Seung Joon Baek
As a major in vivo condensation product of indole-3-carbinol, which is mostly present in cruciferous vegetables, 3,3'-diindolylmethane (DIM) has been previously reported with anti-proliferative action in different types of cancer by our group and others. To further elucidate these underlying mechanisms, we examined the effect of DIM on cyclin D1, which was aberrantly overexpressed in various cancer cells and tumors. Herein, we found that DIM downregulated cyclin D1 expression in colorectal cancer cells (CRC), which was independent of PPARγ expression and protease activity...
June 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28583712/structural-influences-on-the-activity-of-bismuth-iii-indole-carboxylato-complexes-towards-helicobacter-pylori-and-leishmania
#16
Amita Pathak, Victoria L Blair, Richard L Ferrero, Lukasz Kedzierski, Philip C Andrews
Seven new bismuth(III) complexes derived from indole-carboxylic acids have been synthesised: five are homoleptic; [Bi(IAA)3] B1, [Bi(IPA)3] B2, [Bi(IBA)3] B3, [Bi(MICA)3] B4, [Bi(IGA)3] B6, and two are heteroleptic [BiPh(MICA)2] B5 (where IAA-H=2-(1H-indol-3-yl)acetic acid, IPA-H=3-(1H-indol-3-yl)propanoic acid, IBA-H=4-(1H-indol-3-yl)butanoic acid, IGA-H=2-(1H-indol-3-yl)-2-oxoacetic acid, and MICA-H=1-methyl-1H-indole-3-carboxylic acid). All complexes were fully characterised by elemental analysis, infrared and mass-spectroscopy, and nuclear magnetic resonance ((1)H, (13)C) spectroscopy...
May 31, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28573759/persistence-of-plant-hormone-levels-in-rice-shoots-grown-under-microgravity-conditions-in-space-its-relationship-to-maintenance-of-shoot-growth
#17
Kazuyuki Wakabayashi, Kouichi Soga, Takayuki Hoson, Toshihisa Kotake, Mikiko Kojima, Hitoshi Sakakibara, Takashi Yamazaki, Akira Higashibata, Noriaki Ishioka, Toru Shimazu, Motoshi Kamada
We investigated the effects of microgravity environment on growth and plant hormone levels in dark-grown rice shoots cultivated in artificial 1 g and microgravity conditions on the International Space Station (ISS). Growth of microgravity-grown shoots was comparable to that of 1 g-grown shoots. Endogenous levels of indole-3-acetic acid (IAA) in shoots remained constant, while those of abscisic acid (ABA), jasmonic acid (JA), cytokinins (CKs), and gibberellins (GAs) decreased during the cultivation period under both conditions...
June 1, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28572673/simple-rapid-and-efficient-transformation-of-genotype-nisqually-1-a-basic-tool-for-the-first-sequenced-model-tree
#18
Shujuan Li, Cheng Zhen, Wenjing Xu, Chong Wang, Yuxiang Cheng
Genotype Nisqually-1 is the first model woody plant with an available well-annotated genome. Nevertheless, a simple and rapid transformation of Nisqually-1 remains to be established. Here, we developed a novel shoot regeneration method for Nisqually-1 using leaf petiole and stem segment explants. Numerous shoots formed in the incision of explants within two weeks. The optimized shoot regeneration medium (SRM) contained 0.03 mg l(-1) 6-benzylaminopurine, 0.02 mg l(-1) indole-3-butyric acid and 0.0008 mg l(-1) thidiazuron...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28560655/a-randomized-placebo-controlled-trial-of-diindolylmethane-for-breast-cancer-biomarker-modulation-in-patients-taking-tamoxifen
#19
Cynthia A Thomson, H H Sherry Chow, Betsy C Wertheim, Denise J Roe, Alison Stopeck, Gertraud Maskarinec, Maria Altbach, Pavani Chalasani, Chuan Huang, Meghan B Strom, Jean-Philippe Galons, Patricia A Thompson
PURPOSE: Diindolylmethane (DIM), a bioactive metabolite of indole-3-carbinol found in cruciferous vegetables, has proposed cancer chemoprevention activity in the breast. There is limited evidence of clinically relevant activity of DIM or long-term safety data of its regular use. A randomized, double-blind, placebo-controlled trial was conducted to determine the activity and safety of combined use of BioResponse DIM® (BR-DIM) with tamoxifen. METHODS: Women prescribed tamoxifen (n = 130) were randomly assigned oral BR-DIM at 150 mg twice daily or placebo, for 12 months...
May 30, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28554145/physiological-and-biochemical-perspectives-of-non-salt-tolerant-plants-during-bacterial-interaction-against-soil-salinity
#20
REVIEW
Ramalingam Radhakrishnan, Kwang Hyun Baek
Climatic changes on earth affect the soil quality of agricultural lands, especially by increasing salt deposition in soil, which results in soil salinity. Soil salinity is a major challenge to growth and reproduction among glycophytes (including all crop plants). Soil bacteria present in the rhizosphere and/or roots naturally protect plants from the adverse effects of soil salinity by reprogramming the stress-induced physiological changes in plants. Bacteria can enrich the soil with major nutrients (nitrogen, phosphorus, and potassium) in a form easily available to plants and prevent the transport of excess sodium to roots (exopolysaccharides secreted by bacteria bind with sodium ions) for maintaining ionic balance and water potential in cells...
May 22, 2017: Plant Physiology and Biochemistry: PPB
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