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https://www.readbyqxmd.com/read/27919656/biotransformation-of-isofraxetin-6-o-%C3%AE-d-glucopyranoside-by-angelica-sinensis-oliv-diels-callus
#1
Di Zhou, Yuhua Zhang, Zhe Jiang, Yue Hou, Kun Jiao, Chunyan Yan, Ning Li
Isofraxetin-6-O-β-d-glucopyranoside, identified from traditional medicinal herbal Xanthoceras sorbifolia Bunge, has been demonstrated to be a natural neuroinflammatory inhibitor. In order to obtain more derivatives with potential anti-neuroinflammatory effects, biotransformation was carried out. According to the characteristics of coumarin skeleton, suspension cultures of Angelica sinensis (Oliv.) Diels callus (A. sinensis callus) were employed because of the presence of diverse phenylpropanoids biosynthetic enzymes...
November 24, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27916218/fenofibrate-attenuates-malignant-hypertension-by-suppression-of-the-renin-angiotensin-system-a-study-in-cyp1a1-ren-2-transgenic-rats
#2
Šárka Jíchová, Šárka Doleželová, Libor Kopkan, Elzbieta Kompanowska-Jezierska, Janusz Sadowski, Luděk Červenka
BACKGROUND: Malignant hypertension is a life-threatening condition, and its pathophysiology is still poorly understood. The present study was designed to evaluate the role of interaction of the renin-angiotensin system with 20-hydroxyeicosatetraenoic acid (20-HETE), a product of cytochrome P450 (CYP)-dependent ω-hydroxylase pathway, in the pathophysiology of angiotensin II (ANG II)-dependent malignant hypertension in Cyp1a1-Ren-2 transgenic rats. METHODS: Malignant hypertension was induced by 12 days׳ dietary administration of 0...
December 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27911010/screening-of-mercury-resistant-and-indole-3-acetic-acid-producing-bacterial-consortium-for-growth-promotion-of-cicer-arietinum-l
#3
Aatif Amin, Zakia Latif
Mercury resistant (Hg(R) ) bacteria were screened from industrial effluents and effluents-polluted rhizosphere soils near to districts Kasur and Sheikhupura, Pakistan. Out of 60 isolates, three bacterial strains, Bacillus sp. AZ-1, Bacillus cereus AZ-2, and Enterobacter cloacae AZ-3 showed Hg-resistance as 20 μg ml(-1) of HgCl2 and indole-3-acetic acid (IAA) production as 8-38 μg ml(-1) . Biochemical and molecular characterization of selected bacteria was confirmed by 16S ribotyping. Mercury resistant genes merA, merB, and merE of mer operon in Bacillus spp...
December 2, 2016: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/27905924/current-knowledge-and-perspectives-of-paenibacillus-a-review
#4
REVIEW
Elliot Nicholas Grady, Jacqueline MacDonald, Linda Liu, Alex Richman, Ze-Chun Yuan
Isolated from a wide range of sources, the genus Paenibacillus comprises bacterial species relevant to humans, animals, plants, and the environment. Many Paenibacillus species can promote crop growth directly via biological nitrogen fixation, phosphate solubilization, production of the phytohormone indole-3-acetic acid (IAA), and release of siderophores that enable iron acquisition. They can also offer protection against insect herbivores and phytopathogens, including bacteria, fungi, nematodes, and viruses...
December 1, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27902261/paenibacillus-qinlingensis-sp-nov-an-indole-3-acetic%C3%A2-acid-producing-bacterium-isolated-from-roots-of-sinopodophyllum%C3%A2-hexandrum-royle-ying
#5
Kaiyun Xin, Muhang Li, Chaoqiong Chen, Xu Yang, Qiqi Li, Juanli Cheng, Lei Zhang, Xihui Shen
A novel indole-3-acetic acid-producing bacterium, designated TEGT-2T, was isolated from the roots of Sinopodophyllum hexandrum collected from Qinling Mountains in shaanxi province, Northwestern China, and was subjected to a taxonomic study by using a polyphasic approach. Cells of strain TEGT-2T were Gram-stain-positive, strictly aerobic, endospore-forming rods and motile by means of peritrichous flagella. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain TEGT-2T was a member of the genus Paenibacillus, exhibiting the highest sequence similarity to Paenibacillus pectinilyticus KCTC 13222T (97...
November 16, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27901164/metal-catalyst-free-cyclization-of-3-alkynyl-substituted-2-indol-3-yl-quinoxalines-in-tfa-alone-a-new-synthesis-of-indolophenazines
#6
K Shiva Kumar, Boyapally Bhaskar, Meesa Siddi Ramulu, N Praveen Kumar, Mohd Ashraf Ashfaq, Manojit Pal
TFA alone was found to be remarkably effective for the intramolecular hydroarylation (IMHA) of alkynes when employed as a solvent in the cyclization of 3-alkynyl substituted 2-(indol-3-yl)quinoxalines. This simple and metal free cyclization method afforded a range of indolophenazines as new and potential cytotoxic agents. The use of excess TFA was found to be crucial for the success of this reaction.
November 30, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27898393/a-noncanonical-auxin-sensing-mechanism-is-required-for-organ-morphogenesis-in-arabidopsis
#7
Sara Simonini, Joyita Deb, Laila Moubayidin, Pauline Stephenson, Manoj Valluru, Alejandra Freire-Rios, Karim Sorefan, Dolf Weijers, Jiří Friml, Lars Østergaard
Tissue patterning in multicellular organisms is the output of precise spatio-temporal regulation of gene expression coupled with changes in hormone dynamics. In plants, the hormone auxin regulates growth and development at every stage of a plant's life cycle. Auxin signaling occurs through binding of the auxin molecule to a TIR1/AFB F-box ubiquitin ligase, allowing interaction with Aux/IAA transcriptional repressor proteins. These are subsequently ubiquitinated and degraded via the 26S proteasome, leading to derepression of auxin response factors (ARFs)...
October 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/27895099/new-thiazacridine-agents-synthesis-physical-and-chemical-characterization-and-in-vitro-anticancer-evaluation
#8
Mbo Chagas, Ncc Cordeiro, Kmr Marques, M G Rocha Pitta, Mjbm Rêgo, McA Lima, Mgr Pitta, I R Pitta
A series of new thiazacridine agents were synthesized and evaluated as antitumor agents, in terms of not only their cytotoxicity but also their selectivity. The cytotoxicity assay confirmed that all compounds showed cytotoxic activity and selectivity. The new compound, 3-acridin-9-ylmethyl-5-(5-bromo-1H-indol-3-ylmethylene)-thiazolidine-2,4-dione (LPSF/AA29 - 7A: ), proved to be the most promising compound as it presents lower half-maximal inhibitory concentration (IC50) values (ranging from 0.25 to 68.03 µM) depending on cell lineage...
November 27, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27889234/in-silico-and-in-vitro-anti-cancer-potential-of-a-curcumin-analogue-1e-6e-1-7-di-1h-indol-3-yl-hepta-1-6-diene-3-5-dione
#9
Shamim Akhtar Sufi, Lakshmi Narayana Adigopula, Safiulla Basha Syed, Victor Mukherjee, Mohane S Coumar, H Surya Prakash Rao, Rukkumani Rajagopalan
PURPOSE: Previously we showed that BDMC, an analogue of curcumin suppresses growth of human breast and laryngeal cancer cell line by causing apoptosis. Here, we demonstrate the enhanced anti-cancer activity of a heterocyclic ring (indole) incorporated curcumin analogue ((1E, 6E)-1, 7-di (1H-indol-3-yl) hepta-1, 6-diene-3, 5-Dione), ICA in short, in comparison to curcumin. METHOD: ICA was synthesized by a one pot condensation reaction. Anti-cancer potential of ICA was assessed in three human cancer cell lines of different origin (Lung adenocarcinoma (A549), leukemia (K562) and colon cancer (SW480)) by MTT assay...
November 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27888010/indole-3-acetic-acid-diol-based-ph-sensitive-biological-macromolecule-for-antibacterial-antifungal-and-antioxidant-applications
#10
Chitra G, Franklin D S, Sudarsan S, Sakthivel M, Guhanathan S
Indole-3-acetic acid (IAA)/diol based pH-sensitive biopolymeric hydrogels with tunable biological properties (cytotoxicity, anti-oxidant and anti-fungal) have been synthesized via condensation polymerization. The present study focused on the synthesis of heterocyclic hydrogel using citric acid (CA), indole-3-acetic acid (IAA) and diethylene glycol (DEG) by condensation polymerization. The hydrogels revealed a pH-sensitive swelling behaviour, with increased swelling in acidic media, then turns to decreased the swelling in the basic media...
November 22, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27885735/small-acidic-protein-1-smap1-and-scf-tir-1-ubiquitin-proteasome-pathway-act-in-concert-to-induce-2-4-dichlorophenoxyacetic-acid-mediated-alteration-of-actin-in-arabidopsis-roots
#11
Maho Takahashi, Kana Umetsu, Yutaka Oono, Takumi Higaki, Elison B Blancaflor, Abidur Rahman
2,4-dichlorophanoxyacetic acid (2,4-D), a functional analogue of auxin, is used as an exogenous source of auxin as it evokes physiological responses like the endogenous auxin, Indole-3-acetic acid (IAA). Previous molecular analyses of the auxin response pathway revealed that IAA and 2,4-D share a common mode of action to elicit downstream physiological responses. However, recent findings with 2,4-D specific mutants suggested that 2,4-D and IAA might also use distinct pathways to modulate Arabidopsis root growth...
November 25, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/27881728/dii-based-auxin-reporter-in-maize-reveals-low-auxin-signaling-during-telophase-and-early-g1
#12
Ricardo Mir, Leslie Z Aranda, Tiffany Baiocchi, Anding Luo, Anne Sylvester, Carolyn Rasmussen
A sensitive and dynamically responsive auxin signaling reporter based on the DII domain of the INDOLE-3-ACETIC ACID28 (IAA28, DII) protein from Arabidopsis thaliana was modified for use in maize. The DII domain was fused to a yellow fluorescent protein and a nuclear localization sequence to simplify quantitative nuclear fluorescence signal. DII degradation dynamics provide an estimate of input signal into the auxin signaling pathway that is influenced by both auxin accumulation and F-box co-receptor concentration...
November 23, 2016: Plant Physiology
https://www.readbyqxmd.com/read/27880960/antifouling-activity-towards-mussel-by-small-molecule-compounds-from-a-strain-of-vibrio-alginolyticus-bacterium-associated-with-sea-anemone-haliplanella-sp
#13
Xiang Wang, Yanqiu Huang, Yanqing Sheng, Pei Su, Yan Qiu, Caihuan Ke, Danqing Feng
Mussels are major fouling organisms causing serious technical and economic problems. In this study, antifouling activity towards mussel was found in three compounds isolated from a marine bacterium associated with the sea anemone Haliplanella sp.. This bacterial strain, called PE2 was identified as Vibrio alginolyticus using morphology, biochemical tests and phylogenetic analysis based on sequences of 16S rRNA and four housekeeping genes (rpoD, gyrB, rctB and toxR). Three small-molecule compounds (indole, 3-formylindole and cyclo (Pro-Leu)) were purified from the ethyl acetate extract of V...
November 23, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27864737/significance-of-diazotrophic-plant-growth-promoting-herbaspirillum-sp-gw103-on-phytoextraction-of-pband-zn-by-zea-mays-l
#14
Loganathan Praburaman, Sung-Hee Park, Min Cho, Kui-Jae Lee, Jeong-Ae Ko, Sang-Sub Han, Sang-Hyun Lee, Seralathan Kamala-Kannan, Byung-Taek Oh
Microbe-assisted phytoremediation has been considered a promising measure for the remediation of heavy metal-polluted soil. The aim of this study was to assess the effect of diazotrophic plant growth-promoting Herbaspirillum sp. GW103 on growth and lead (Pb) and zinc (Zn) accumulation in Zea mays L. The strain GW103 exhibited plant growth-promoting traits such as indole-3-acetic acid, siderophores, and 1-aminocyclopropane-1-carboxylic deaminase. Treatment of Z. mays L. plants with GW103 significantly increased 19, 31, and 52% of plant biomass and 10, 50, and 126% of chlorophyll a contents in Pb, Zn, and Pb + Zn-amended soils, respectively...
November 18, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27863916/structure-activity-relationship-study-towards-non-peptidic-positron-emission-tomography-pet-radiotracer-for-gastrin-releasing-peptide-receptors-development-of-18-f-s-3-1h-indol-3-yl-n-1-5-2-fluoroethoxy-pyridin-2-yl-cyclohexylmethyl-2-methyl-2-3-4-nitrophenyl
#15
Enza Lacivita, Ermelinda Lucente, Chantal Kwizera, Ines F Antunes, Mauro Niso, Paola De Giorgio, Roberto Perrone, Nicola A Colabufo, Philip H Elsinga, Marcello Leopoldo
Gastrin-releasing peptide receptors (GRP-Rs, also known as bombesin 2 receptors) are overexpressed in a variety of human cancers, including prostate cancer, and therefore they represent a promising target for in vivo imaging of tumors using positron emission tomography (PET). Structural modifications of the non-peptidic GRP-R antagonist PD-176252 ((S)-1a) led to the identification of the fluorinated analog (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide ((S)-1m) that showed high affinity and antagonistic properties for GRP-R...
October 29, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27856239/discovery-of-novel-multi-target-indole-based-derivatives-as-potent-and-selective-inhibitors-of-chikungunya-virus-replication
#16
Maria Scuotto, Rana Abdelnabi, Selene Collarile, Chiara Schiraldi, Leen Delang, Antonio Massa, Salvatore Ferla, Andrea Brancale, Pieter Leyssen, Johan Neyts, Rosanna Filosa
We recently identified indole derivatives (IIIe and IIIf) with anti-chikungunya virus (CHIKV) activities at lower micro molar concentrations and a selective index of inhibition higher than the lead compound Arbidol. Here we highlight new structural information for the optimization of the previously identified lead compounds that contain the indole chemical core. Based on the structural data, a series of indole derivatives was synthesized and tested for their antiviral activity against chikungunya virus in Vero cell culture by a CPE reduction assay...
October 31, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27855786/dynamic-metabolic-exchange-governs-a-marine-algal-bacterial-interaction
#17
Einat Segev, Thomas P Wyche, Ki Hyun Kim, Jörn Petersen, Claire Ellebrandt, Hera Vlamakis, Natasha Barteneva, Joseph N Paulson, Liraz Chai, Jon Clardy, Roberto Kolter
Emiliania huxleyi is a model coccolithophore micro-alga that generates vast blooms in the ocean. Bacteria are not considered among the major factors influencing coccolithophore physiology. Here we show through a laboratory model system that the bacterium Phaeobacter inhibens, a well-studied member of the Roseobacter group, intimately interacts with E. huxleyi. While attached to the algal cell, bacteria initially promote algal growth but ultimately kill their algal host. Both algal growth enhancement and algal death are driven by the bacterially-produced phytohormone indole-3-acetic acid...
November 18, 2016: ELife
https://www.readbyqxmd.com/read/27849615/arabidopsis-thaliana-gh3-5-acyl-acid-amido-synthetase-mediates-metabolic-crosstalk-in-auxin-and-salicylic-acid-homeostasis
#18
Corey S Westfall, Ashley M Sherp, Chloe Zubieta, Sophie Alvarez, Evelyn Schraft, Romain Marcellin, Loren Ramirez, Joseph M Jez
In Arabidopsis thaliana, the acyl acid amido synthetase Gretchen Hagen 3.5 (AtGH3.5) conjugates both indole-3-acetic acid (IAA) and salicylic acid (SA) to modulate auxin and pathogen response pathways. To understand the molecular basis for the activity of AtGH3.5, we determined the X-ray crystal structure of the enzyme in complex with IAA and AMP. Biochemical analysis demonstrates that the substrate preference of AtGH3.5 is wider than originally described and includes the natural auxin phenylacetic acid (PAA) and the potential SA precursor benzoic acid (BA)...
November 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27845247/indole-3-acetic-acid-production-via-the-indole-3-pyruvate-pathway-by-plant-growth-promoter-rhizobium-tropici-ciat-899-is-strongly-inhibited-by-ammonium
#19
Eddie Luidy Imada, Amanda Alves de Paiva Rolla Dos Santos, André Luiz Martinez de Oliveira, Mariangela Hungria, Elisete Pains Rodrigues
Like many rhizobia, Rhizobium tropici produces indole-3-acetic acid (IAA), an important signal molecule required for root hair infection in rhizobia-legume symbioses. However, the IAA biosynthesis pathway and its regulation by R. tropici are still poorly understood. In this study, IAA synthesis and the effects of mineral N in IAA production by R. tropici CIAT 899 were verified by ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). Furthermore, expression of genes related to IAA biosynthesis and metabolism were evaluated by RT-qPCR...
November 11, 2016: Research in Microbiology
https://www.readbyqxmd.com/read/27834143/distribution-of-synthetic-cannabinoids-jwh-210-rcs-4-and-%C3%A2-9-tetrahydrocannabinol-after-intravenous-administration-to-pigs
#20
Nadine Schaefer, Mattias Kettner, Matthias W Laschke, Julia Schlote, Andreas H Ewald, Michael D Menger, Hans H Maurer, Peter H Schmidt
Synthetic cannabinoids (SCs) have become an increasing issue in forensic toxicology. Controlled human studies evaluating pharmacokinetic data of SCs are lacking and only few animal studies have been published. Thus, an interpretation of analytical results found in intoxicated or poisoned individuals is difficult. Therefore, the distribution of two selected SCs, namely 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-210) and 2-(4-methoxyphenyl)-1-(1-pentyl-indol-3-yl)methanone (RCS-4) as well as ∆9-tetrahydrocannabinol (THC) as reference were examined in pigs...
November 11, 2016: Current Neuropharmacology
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