Iris Mathijs, Daniel A Da Cunha, Eddy Himpe, Laurence Ladriere, Nireshni Chellan, Candice R Roux, Elizabeth Joubert, Christo Muller, Miriam Cnop, Johan Louw, Luc Bouwens
SCOPE: A major goal of diabetes therapy is to identify novel drugs that preserve or expand pancreatic beta cell mass. Here, we examined the effect of a phenylpropenoic acid glucoside (PPAG) on the beta cell mass, and via which mechanism this effect is established. METHODS AND RESULTS: Mice were fed a high-fat and fructose-containing diet to induce obesity and hyperglycemia. PPAG treatment protected obese mice from diet-induced hyperglycemia and resulted in a tripling of beta cell mass...
October 2014: Molecular Nutrition & Food Research