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Beta cells AND PPAG

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https://www.readbyqxmd.com/read/27299564/phenylpropenoic-acid-glucoside-from-rooibos-protects-pancreatic-beta-cells-against-cell-death-induced-by-acute-injury
#1
Eddy Himpe, Daniel A Cunha, Imane Song, Marco Bugliani, Piero Marchetti, Miriam Cnop, Luc Bouwens
OBJECTIVE: Previous studies demonstrated that a phenylpropenoic acid glucoside (PPAG) from rooibos (Aspalathus linearis) extract had anti-hyperglycemic activity and significant protective effects on the pancreatic beta cell mass in a chronic diet-induced diabetes model. The present study evaluated the cytoprotective effect of the phytochemical on beta cells exposed to acute cell stress. METHODS: Synthetically prepared PPAG was administered orally in mice treated with a single dose of streptozotocin to acutely induce beta cell death and hyperglycemia...
2016: PloS One
https://www.readbyqxmd.com/read/25044754/phenylpropenoic-acid-glucoside-augments-pancreatic-beta-cell-mass-in-high-fat-diet-fed-mice-and-protects-beta-cells-from-er-stress-induced-apoptosis
#2
Iris Mathijs, Daniel A Da Cunha, Eddy Himpe, Laurence Ladriere, Nireshni Chellan, Candice R Roux, Elizabeth Joubert, Christo Muller, Miriam Cnop, Johan Louw, Luc Bouwens
SCOPE: A major goal of diabetes therapy is to identify novel drugs that preserve or expand pancreatic beta cell mass. Here, we examined the effect of a phenylpropenoic acid glucoside (PPAG) on the beta cell mass, and via which mechanism this effect is established. METHODS AND RESULTS: Mice were fed a high-fat and fructose-containing diet to induce obesity and hyperglycemia. PPAG treatment protected obese mice from diet-induced hyperglycemia and resulted in a tripling of beta cell mass...
October 2014: Molecular Nutrition & Food Research
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