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Walter Fontana

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https://www.readbyqxmd.com/read/28574652/accuracy-and-consistency-of-anti-xa-activity-measurement-for-determination-of-rivaroxaban-plasma-levels
#1
Jan-Dirk Studt, Lorenzo Alberio, Anne Angelillo-Scherrer, Lars M Asmis, Pierre Fontana, Wolfgang Korte, Adriana Mendez, Pirmin Schmid, Hans Stricker, Dimitrios A Tsakiris, Walter A Wuillemin, Michael Nagler
BACKGROUND: Determining the plasma level of direct oral anticoagulants reliably is important in the work-up of complex clinical situations. OBJECTIVES: To study the accuracy and consistency of anti-Xa assays for rivaroxaban plasma concentration in a prospective, multicentre evaluation study employing different reagents and analytical platforms. METHODS: Rivaroxaban 20 mg was administered once daily to 20 healthy volunteers and blood samples were taken at peak and trough level (clinicaltrials...
June 2, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28502395/multicenter-evaluation-of-the-rapidec%C3%A2-carba-np-test-for-rapid-screening-of-carbapenemase-producing-enterobacteriaceae-and-gram-negative-nonfermenters-from-clinical-specimens
#2
Marco Coppi, Alberto Antonelli, Tommaso Giani, Teresa Spanu, Flora Marzia Liotti, Carla Fontana, Walter Mirandola, Raffaele Gargiulo, Agostino Barozzi, Carola Mauri, Luigi Principe, Gian Maria Rossolini
The rapid diagnosis of carbapenemase-producing (CP) bacteria is essential for the management of therapy and infection control. In this study, RAPIDEC® CARBA NP (RCNP) was evaluated for the rapid screening of CP Enterobacteriaceae, Acinetobacter baumannii complex, and Pseudomonas aeruginosa from clinical specimens collected at five Italian hospitals. Firstly, each site tested 20 well-characterized strains in a blinded fashion. Secondly, each center prospectively tested 25 isolates from blood cultures processed with a rapid workflow (6h after subculture) and 25 isolates from other specimens processed after an overnight culture...
April 27, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28343143/impact-of-rivaroxaban-on-point-of-care-assays
#3
Pierre Fontana, Lorenzo Alberio, Anne Angelillo-Scherrer, Lars M Asmis, Wolfgang Korte, Adriana Mendez, Pirmin Schmid, Hans Stricker, Jan-Dirk Studt, Dimitrios A Tsakiris, Walter A Wuillemin, Michael Nagler
BACKGROUND: Point-of-care testing (POCT) is regularly used to assess haemostasis in various clinical settings. The impact of rivaroxaban on those POCT is still elusive. We aimed to study the effects of rivaroxaban on most commonly used POCT assays. METHODS: Blood samples were taken before, 3h, and 24h after administration of 20mg rivaroxaban to 20 healthy volunteers as part of a prospective, multicenter validation study (clinicaltrials.govNCT01710267). Blood samples were analysed with thromboelastometry (ROTEM®), two platelet function assays (INNOVANCE® PFA-200 and Multiplate®), and the CoaguChek® XS...
March 21, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28173833/human-breast-adipose-tissue-characterization-of-factors-that-change-during-tumor-progression-in-human-breast-cancer
#4
Sabrina Johanna Fletcher, Paula Alejandra Sacca, Mercedes Pistone-Creydt, Federico Andrés Coló, María Florencia Serra, Flavia Eliana Santino, Corina Verónica Sasso, Constanza Matilde Lopez-Fontana, Rubén Walter Carón, Juan Carlos Calvo, Virginia Pistone-Creydt
BACKGROUND: Adipose microenvironment is involved in signaling pathways that influence breast cancer. We aim to characterize factors that are modified: 1) in tumor and non tumor human breast epithelial cell lines when incubated with conditioned media (CMs) from human breast cancer adipose tissue explants (hATT) or normal breast adipose tissue explants (hATN); 2) in hATN-CMs vs hATT-CMs; 3) in the tumor associated adipocytes vs. non tumor associated adipocytes. METHODS: We used hATN or hATT- CMs on tumor and non-tumor breast cancer cell lines...
February 7, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27884868/combined-associations-of-body-weight-and-lifestyle-factors-with-all-cause-and-cause-specific-mortality-in-men-and-women-prospective-cohort-study
#5
Nicola Veronese, Yanping Li, JoAnn E Manson, Walter C Willett, Luigi Fontana, Frank B Hu
OBJECTIVE:  To evaluate the combined associations of diet, physical activity, moderate alcohol consumption, and smoking with body weight on risk of all cause and cause specific mortality. DESIGN:  Longitudinal study with up to 32 years of follow-up. SETTING:  Nurses' Health Study (1980-2012) and Health Professionals Follow-up Study (1986-2012). PARTICIPANTS:  74 582 women from the Nurses' Health Study and 39 284 men from the Health Professionals Follow-up Study who were free from cardiovascular disease and cancer at baseline...
November 24, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27686460/esicm-lives-2016-part-two-milan-italy-1-5-october-2016
#6
S Sivakumar, F S Taccone, K A Desai, C Lazaridis, M Skarzynski, M Sekhon, W Henderson, D Griesdale, L Chapple, A Deane, L Williams, R Strickland, K Lange, D Heyland, M Chapman, M J Rowland, P Garry, J Westbrook, R Corkill, C A Antoniades, K T Pattinson, G Fatania, A J Strong, R B Myers, C Lazaridis, C M Jermaine, C S Robertson, C G Rusin, J Hofmeijer, L Sondag, M C Tjepkema-Cloostermans, A Beishuizen, F H Bosch, M J A M van Putten, L Carteron, C Patet, D Solari, M Oddo, M A Ali, C Dias, R Almeida, A Vaz-Ferreira, J Silva, E Monteiro, A Cerejo, A P Rocha, A A Elsayed, A M Abougabal, B N Beshey, K M Alzahaby, S Pozzebon, A Blandino Ortiz, S Cristallini, O Lheureux, A Brasseur, J L Vincent, J Creteur, F S Taccone, M Hravnak, K Yousef, Y Chang, E Crago, R M Friedlander, S A Abdelmonem, S A Tahon, T A Helmy, H S Meligy, F Puig, I Dunn-Siegrist, J Pugin, S Gupta, D Govil, S Srinivasan, S J Patel, J K N, A Gupta, D S Tomar, M Shafi, R Harne, D P Arora, N Talwar, S Mazumdar, E E Papakrivou, D Makris, E Manoulakas, B Tsolaki, B Karadodas, E Zakynthinos, I Palacios Garcia, A Diaz Martin, V Sanchez Encinares, M Pachón Ibañez, J Garnacho Montero, G Labrador, T Cebrero Cangueiro, V Poulose, J Koh, J W Kam, H Yeter, A Kara, O Aktepe, A Topeli, I Tsolakoglou, G Intas, P Stergiannis, A A Kolaros, E Chalari, E Athanasiadou, A Martika, G Fildisis, V Faivre, C Mengelle, B Favier, D Payen, A Poppe, M S Winkler, E Mudersbach, J Schreiber, M L Wruck, E Schwedhelm, S Kluge, C Zöllner, T Tavladaki, A M Spanaki, H Dimitriou, E Kondili, C Choulaki, E Meleti, D Kafetzopoulos, D Georgopoulos, G Briassoulis, A García-de la Torre, M V de la Torre-Prados, T Tsvetanova-Spasova, P Nuevo-Ortega, C Rueda-Molina, A Fernández-Porcel, E Camara-Sola, L Salido-Díaz, A García-Alcántara, T Tavladaki, A M Spanaki, H Dimitriou, E Kondili, C Choulaki, D E Meleti, D Kafetzopoulos, D Georgopoulos, G Briassoulis, B Suberviola, J Riera, L Rellan, M Sanchez, J C Robles, E Lopez, R Vicente, E Miñambres, M Santibañez, M Le Guen, J Moore, N Mason, M Windpassinger, O Plattner, E Mascha, D I Sessler, Outcomes Research, U Melia, J Fontanet, J P van den Berg, M M R F Struys, H E M Vereecke, E W Jensen, P J T Rood, F van de Schoor, K van Tertholen, P Pickkers, M van den Boogaard, Z J Beardow, H Redhead, K Paramasivam, T Numan, M van den Boogaard, A M Kamper, P Rood, L M Peelen, P M Zeman, A J Slooter, C E van Ewijk, G E Jacobs, A R J Girbes, S N Myatra, M M Harish, N R Prabu, S Siddiqui, A P Kulkarni, J V Divatia, L D Murbach, M A Leite, E F Osaku, C R L M Costa, M Pelenz, N M Neitzke, M M Moraes, J L Jaskowiak, M M M Silva, R S Zaponi, L R L Abentroth, S M Ogasawara, A C Jorge, P A D Duarte, N Hernández-Sánchez, L A Sánchez-Hurtado, F J García-Guillen, S A Ñamendys-Silva, B Maghsoudi, M Emami, M B Khosravi, F Zand, H R Tabatabaie, M Masjedi, G Sabetiyan, A Mokri, J Troubleyn, M Diltoer, R Jacobs, D N Nguyen, E De Waele, J De Regt, P M Honoré, V Van Gorp, H D Spapen, R S Contreras, N D Toapanta, G Moreno, J Sabater, H Torrado, M Gonzalez, M Marin, E Farigola, A Gonzalez, J Fernandez, A Vera, X Gisbert, C Juliá, J Uya, L Corral, I Elias-Jones, L Gemmell, A MacKay, D Randall, A Adwaney, M Blunden, J R Prowle, C J Kirwan, N Thomas, A Martin, H Owen, L Darwin, D Conway, D Atkinson, M Sharman, J Moore, C Barbanti, J Amour, P Gaudard, B Rozec, P Mauriat, M M'rini, P L Leger, G Cambonie, J M Liet, C Girard, S Laroche, P Damas, Z Assaf, G Loron, L Lecourt, P Pouard, D Randall, A Adwaney, M Blunden, J R Prowle, C J Kirwan, S H Kim, S Na, J Kim, S Y Oh, C W Jung, S H Yoo, S H Min, E J Chung, H Lee, N J Lee, K W Lee, K S Suh, H G Ryu, D C Marshall, R J Goodson, J D Salciccioli, J Shalhoub, E K Potter, J Kirk-Bayley, N D Karanjia, L G Forni, B C Creagh-Brown, M Bossy, M Nyman, A Tailor, B Creagh-Brown, D D'Antini, S Spadaro, F Valentino, F Sollitto, G Cinnella, L Mirabella, F J Redondo Calvo, N Bejarano, D Padilla, V Baladron, P Villajero, R Villazala, J Redondo, A S Yuste, J Liu, F Shen, J L Teboul, N Anguel, A Beurton, N Bezaz, C Richard, X Monnet, T Fossali, R Colombo, D Ottolina, M Rossetti, C Mazzucco, A Marchi, A Porta, E Catena, K H Tollisen, G Ø Andersen, F Heyerdahl, D Jacobsen, M C de Waard, A R J Girbes, M C O van IJzendoorn, H Buter, W P Kingma, G J Navis, E C Boerma, J Rulisek, M Balik, S Zacharov, H S Kim, S J Jeon, H Namgung, E Lee, E Lee, Y J Cho, Y J Lee, A Huang, L Cioccari, N Luethi, J Mårtensson, R Bellomo, M Forsberg, G Edman, J Höjer, S Forsberg, M T Chiquito Freile, F N Hidalgo, J A Martinez Molina, R Lecumberri, A Figuerola Rosselló, P Medrano Travieso, G Tuero Leon, J Gonzalez Sanchez, L Sahuquillo Frias, D Balsells Rosello, J A Garcia Verdejo, J A Noria Serrano, D Winterwerp, T van Galen, A Vazin, I Karimzade, A Zand, E Ozen, S Ekemen, A Akcan, E Sen, B Buyukkidan Yelken, N Kureshi, L Fenerty, G Thibault-Halman, M Erdogan, S Walling, R S Green, D B Clarke, P Briassoulis, K Kalimeris, A Ntzouvani, T Nomikos, K Papaparaskeva, E Politi, G Kostopanagiotou, K Crewdson, M Rehn, A Weaver, K Brohi, D Lockey, S Wright, K Thomas, C Baker, L Mansfield, V Stafford, C Wade, G Watson, A Bryant, T Chadwick, J Shen, J Wilkinson, J Furneval, A Henderson, K Hugill, P Howard, A Roy, S Bonner, S Baudouin, C Sánchez Ramírez, S Hípola Escalada, M A Hernández Viera, M Cabrera Santana, L Caipe Balcázar, N Sangil Monroy, F Artiles Campelo, C F Lübbe Vázquez, P Saavedra Santana, S Ruiz Santana, L Carteron, C Patet, H Quintard, D Solari, P Bouzat, M Oddo, T Wollersheim, J Malleike, K Haas, N Carbon, J Schneider, C Birchmeier, J Fielitz, S Spuler, S Weber-Carstens, L Enseñat, A Pérez-Madrigal, P Saludes, L Proença, G Gruartmoner, C Espinal, J Mesquida, W Huber, M Eckmann, F Elkmann, A Gruber, T Lahmer, U Mayr, A Herner, R Schellnegger, J Schneider, R M Schmid, W Ayoub, W Samy, A Esmat, A Battah, S Mukhtar, W Mongkolpun, D Orbegozo Cortés, C P R Cordeiro, J L Vincent, J Creteur, S Funcke, H Groesdonk, B Saugel, G Wagenpfeil, S Wagenpfeil, D A Reuter, M M Fernandez, R Fernandez, M Magret, A González-Castro, M T Bouza, M Ibañez, C García, B Balerdi, A Mas, V Arauzo, J M Añón, F Ruiz, J Ferreres, R Tomás, M Alabert, A I Tizón, S Altaba, N Llamas, E C Goligher, E Fan, M Herridge, S Vorona, M Sklar, M Dres, N Rittayamai, A Lanys, C Urrea, G Tomlinson, W D Reid, G D Rubenfeld, B P Kavanagh, L J Brochard, N D Ferguson, A Serpa Neto, M Gama de Abreu, P Pelosi, M J Schultz, C Guérin, L Papazian, J Reignier, L Ayzac, A Loundou, J M Forel, C Rolland-Debord, C Bureau, T Poitou, M Clavel, S Perbet, N Terzi, A Kouatchet, T Similowski, A Demoule, N Hunfeld, Z Trogrlic, S Ladage, R J Osse, B Koch, W Rietdijk, J Devlin, M van der Jagt, E Picetti, P Ceccarelli, F Mensi, L Malchiodi, S Risolo, I Rossi, M V Antonini, F Servadei, M L Caspani, A Roquilly, S Lasocki, P Seguin, T Geeraerts, P F Perrigault, C Dahyot-Fizelier, C Paugam-Burtz, F Cook, R Cinotti, D Demeure Dit Latte, P J Mahe, C Fortuit, F Feuillet, K Asehnoune, C Marzorati, S Spina, V Scaravilli, A Vargiolu, M Riva, C Giussani, E Sganzerla, G Citerio, S Barbadillo, F J González de Molina, F Álvarez-Lerma, A Rodríguez, T Zakharkina, I Martin-Loeches, S Matamoros, P Povoa, A Torres, J Kastelijn, J J Hofstra, M de Jong, M Schultz, P Sterk, A Artigas, L J Bos, A S Moreau, I Martin-Loeches, P Povoa, J Salluh, A Rodriguez, S Nseir, E de Jong, J A van Oers, A Beishuizen, A R J Girbes, M W N Nijsten, D W de Lange, D Bonvicini, D Labate, L Benacchio, A Olivieri, E Pizzirani, J C Lopez-Delgado, M Gonzalez-Romero, V Fuentes-Mila, D Berbel-Franco, I Romera-Peregrina, A Martinez-Pascual, J Perez-Sanchez, R Abellan-Lencina, R E Ávila-Espinoza, G Moreno-Gonzalez, F Sbraga, S Griffiths, M P W Grocott, B Creagh-Brown, J Doyle, P Wilkerson, Y Soon, S Huddart, M Dickinson, A Riga, A Zuleika, K Miyamoto, Y Kawazoe, T Morimoto, T Yamamoto, A Fuke, A Hashimoto, H Koami, S Beppu, Y Katayama, M Ito, Y Ohta, H Yamamura, S L Rygård, L B Holst, J Wetterslev, P I Johansson, A Perner, I W Soliman, D W de Lange, D van Dijk, J J M van Delden, O L Cremer, A J C Slooter, L M Peelen, D McWilliams, C Snelson, A Das Neves, C I Loudet, M Busico, D Vazquez, D Villalba, M Veronesi, A Lischinsky, F J L López, L Benito Mori, G Plotnikow, A Díaz, S Giannasi, R Hernandez, L Krzisnik, C Cecotti, L Viola, R Lopez, J P Sottile, G Benavent, E Estenssoro, C M Chen, C C Lai, K C Cheng, W Chou, K S Chan, L E Roeker, C M Horkan, F K Gibbons, K B Christopher, P J M Weijs, K M Mogensen, J D Rawn, M K Robinson, K B Christopher, Z Tang, C Qiu, B Ouyang, C Cai, X Guan, T Regueira, L Cea, S Juan Carlos, B Elisa, C Puebla, A Vargas, M K Poulsen, L P Thomsen, S Kjærgaard, S E Rees, D S Karbing, T Wollersheim, S Frank, M C Müller, N M Carbon, V Skrypnikov, P A Pickerodt, R Falk, A Mahlau, S Weber-Carstens, A Lee, R Inglis, R Morgan, G Barker, K Kamata, T Abe, D Saitoh, Y Tokuda, R S Green, M B Butler, M Erdogan, H Tae Hwa, L Jae Gil, R Hernández Vaquero, E Rodriguez-Ruiz, A Lopez Lago, J L Garcia Allut, A Estany Gestal, M A Garcia Gonzalez, D O Thomas-Rüddel, D Schwarzkopf, C Fleischmann, K Reinhart, S Suwanpasu, Y Sattayasomboon, N M Filgueiras Filho, J C A Oliveira, C S Ballalai, C V De Lucia, G P Araponga, L N Veiga, C S Silva, M E Garrido, B B Ramos, E F Ricaldi, S S Gomes, L Gemmell, A MacKay, C Wright, R I Docking, P Doherty, E Black, P Stenhouse, M P Plummer, M E Finnis, L K Phillips, P Kar, S Bihari, V Biradar, S Moodie, M Horowitz, J E Shaw, A M Deane, T Yatabe, S Inoue, M Sakaguchi, M Egi, Y Ali Abdelhamid, M P Plummer, M E Finnis, L K Phillips, P Kar, S Bihari, V Biradar, S Moodie, M Horowitz, J E Shaw, A M Deane, M Hokka, M Egi, S Mizobuchi, P Kar, M Plummer, Y Ali Abdelhamid, E Giersch, M Summers, S Hatzinikolas, S Heller, M Chapman, K Jones, M Horowitz, A Deane, R Schweizer, M Jacquet-Lagreze, P Portran, S Junot, B Allaouchiche, J L Fellahi, P Guerci, B Ergin, A Kapucu, C Ince, L Cioccari, N Luethi, M Crisman, R Bellomo, J Mårtensson, C Righy Shinotsuka, D Fagnoul, A Brasseur, D Orbegozo, J L Vincent, J C Preiser, J C Preiser, O Lheureux, A Thooft, S Brimioulle, J L Vincent, H Iwasaka, S Tahara, M Nagamine, A Ichigatani, A Rugerio Cabrera, E Monares Zepeda, J Franco Granillo, J S Aguirre Sánchez, A A Tanaka Montoya, A Pedraza Montenegro, G A Gálvez Blanco, C M Coronado Robles, A Drolz, T Horvatits, K Roedl, K Rutter, S Kluge, G C Funk, B Schneeweiss, V Fuhrmann, G Sabetian, F Pooresmaeel, F Zand, S Ghaffaripour, A Farbod, H Tabei, L Taheri, R Anandanadesan, V Metaxa, C Teixeira, S M Pereira, P Hernández-Marrero, A S Carvalho, M Beckmann, C S Hartog, D Schwarzkopf, A Raadts, A Robertsen, R Førde, N O Skaga, E Helseth, S Honeybul, K Ho, P Martinez Lopez, M Nieto Gonzalez, P Nuevo Ortega, E Camara Sola, T Spasova, M V de la Torre-Prados, O Kopecky, K Rusinova, P Waldauf, Z Cepeplikova, M Balik, J Palamidessi Domínguez, P Matia Almudevar, S Alcántara Carmona, J J Rubio Muñoz, D Palacios Castañeda, A Naharro Abellán, P Rodríguez Villamizar, J Veganzones Ramos, L Pérez Pérez, A Pérez Lucendo, M Camós Ejarque, A Estella, V Lopez Camps, M C Martín, N Masnou, S Barbosa, A Varela, I Palma, L Cristina, E Nunes, I Pereira, G Campello, C Granja, R Pande, M Pandey, S Varghese, M Chanu, M J Van Dam, E W M T Ter Braak, A Estella, M Gracia, R Viciana, M Recuerda, L Perez Fontaiña, B Tharmalingam, F Kovari, L Rose, M Mcginlay, R Amin, K Burns, B Connolly, N Hart, P Jouvet, S Katz, D Leasa, C Mawdsley, D Mcauley, M Schultz, B Blackwood, S Denham, R Worrall, M Arshad, P Isherwood, A Khadjibaev, D Sabirov, A Rosstalnaya, F Parpibaev, V Sharipova, G A Galvez Blanco, C I Olvera Guzman, J S Aguirre Sánchez, J Franco Granillo, S Gupta, D Govil, S Srinivasan, S J Patel, J K N, A Gupta, M Shafi, D S Tomar, R Harne, D P Arora, N Talwar, S Mazumdar, Y S Cha, S J Lee, N Tyagi, R K Rajput, S Taneja, V K Singh, S C Sharma, S Mittal, B K Rao, J Ayachi, N Fraj, S Romdhani, A Khedher, K Meddeb, N Sma, A Azouzi, R Bouneb, I Chouchene, M El Ghardallou, M Boussarsar, R Jennings, E Walter, J M Ribeiro, I Moniz, R Marçal, A C Santos, C Candeias, Z Costa E Silva, S E Zamora Gomez, O R Perez Nieto, J A Castanon Gonzalez, A I Vasquez Cuellar, H Mildh, V Pettilä, A M Korhonen, S Karlsson, T Ala-Kokko, M Reinikainen, S T Vaara, M Zaleska-Kociecka, M Grabowski, M Dąbrowski, S Wozniak, K Piotrowska, M Banaszewski, J Imiela, J Stepinska, A González Pérez, P Florez Ordoñez, A Giribet, M A Alonso Cuervo, R Alonso Cuervo, M A Rodriguez Esteban, L Iglesias Fraile, C Ponte Mittelbrum, G Muñiz Albaiceta, J Koeze, F Keus, W Dieperink, I C C van der Horst, M van Meurs, J G Zijlstra, S Roberts, C Hernandez Caballero, G Isgro, D Hall, S Beitland, A-M S Trøseid, B S Brusletto, B E Waldum-Grevbo, J P Berg, K Sunde, D García Huertas, F Manzano, M M Jiménez- Quintana, A Osuna, F Santiago-Ruiz, C Rodríguez-Mejías, R Wangensteen, H R Jamaati, M Masjedi, F Zand, S M R Hashemian, G Sabetian, G Abbasi, V Khaloo, S H A Tabei, A Kafilzadeh, H Haddad Bakhodaei, J A Diaz, R Silva, D J Garcia, E Luis, M N Gomez, R Soriano, P L Gonzalez, I A Ibrahim, M M Rafik, A M Al-Ansary, M A Algendi, A A Ali, V Fuhrmann, K Roedl, T Horvatits, A Drolz, K Rutter, D Benten, J Kluwe, S Siedler, S Kluge, I Adedugbe, G T Bird, R M Kennedy, S Sharma, M B Butler, G Yugi, B A Haroon, T Witter, W Khaliq, M Singer, A A Havaldar, B Krishna, S Sriram, E D Valenzuela Espinoza, M O Pozo, V S Kanoore Edul, M Furche, M F Motta, A Risso Vazquez, P N Rubatto Birri, C Ince, A Dubin, A Dogliotti, A Ramos, C Lovesio, E Delile, R Nevière, P-A Thiébaut, J Maupoint, P Mulder, D Coquerel, S Renet, J C do Rego, J Rieusset, V Richard, F Tamion, W Khaliq, D T Andreis, M Singer, B Smit, Y M Smulders, M C de Waard, H M Oudemans van Straaten, A R J Girbes, E C Eringa, A M E Spoelstra-de Man, L Alegría, D Soto, C Luengo, J Gomez, N Jarufe, A Bruhn, R Castro, E Kattan, P Tapia, R Rebolledo, P Achurra, G Ospina-Tascón, J Bakker, G Hernández, P Bertini, F Guarracino, R Baldassarri, M R Pinsky, L Alegría, M Vera, J Dreyse, D Carpio, C Henriquez, D Gajardo, S Bravo, R Castro, G Ospina-Tascón, J Bakker, G Hernández, S Kim, M Lee, S Y Park, S So, H Lee, M B Kačar, S M Kačar, I Uddin, A M Belhaj, M A Aydın, D Avsec, A Kapuağası, Ç Kaymak, L Kovach, I Şencan, B Meço, M Özçelik, N Ünal, C Lazaridis, B Jenni-Moser, M-M Jeitziner, M S Galassi, F L Sales, K C L de Moraes, C L Batista, J A de Souza Júnior, T B Marcari, R Lobato, C S A A Castro, L M de Souza, F F P Rodrigues, N G Correa, A M Pelegrini, R A C Eid, K T Timenetsky, D Cazati, M Lobato, P S Diniz, L L Rocha, A M Cavalheiro, N M Lucinio, E R Santos, M Norrenberg, A Gleize, J C Preiser, I Fernández Simón, S Alcántara Carmona, I Lipperheide Valhonrat, J Palamidessi Domínguez, A Naharro Abellán, P Matía Almudévar, F Dávila, J J Rubio, A J Ramos, Á J Roldán Reina, N Palomo López, M Adriaensens Pérez, D X Cuenca Apolo, L Martín Villén, F M Porras López, I Palacios García, J R Naranjo Izurieta, J J Egea Guerrero, S Calvert, M Quint, K Adeniji, R Young, D D Shevill, E Robertson, P Garside, E Walter, P Isotti, M M De Vecchi, A E Perduca, A Negro, G Villa, D F Manara, L Cabrini, A Zangrillo, J F Frencken, L van Baal, L M Peelen, D W Donker, J Horn, T van der Poll, W A van Klei, M J M Bonten, O L Cremer, C E Menard, A Kumar, E Rimmer, S Doucette, A F Turgeon, B L Houston, D S Houston, R Zarychanski, B Bollen Pinto, M Carrara, M Ferrario, K Bendjelid, J Nunes, P Diaz, G Silva, S Escórcio, S Chaves, M Jardim, N Fernandes, M Câmara, R Duarte, C A Pereira, J Vieira, J J Nóbrega, C M Coronado Robles, M A Montes de Oca-Sandoval, A Sánchez-Rodríguez, J G Joya-Galeana, A Correa-Morales, G Camarena-Alejo, J Aguirre-Sánchez, J Franco-Granillo, M Soliman, A Al Azab, R El Hossainy, H Nagy, M Nirmalan, I A Crippa, F Zama Cavicchi, J L Vincent, J Creteur, F S Taccone, A Chaari, K Abdel Hakim, H Hassanein, M Etman, M El Bahr, K Bousselmi, E S Khalil, V Kauts, W F Casey, H Imahase, Y 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Tagliabue, M Ji, J V Suneby Jagers, P A Easton, R B Souza, A M A Liberatore, A M C R P F Martins, J C F Vieira, Y R Kang, M N Nakamae, I H J Koh, J Y Hong, M H Shin, M S Park, A Pomprapa, P A Pickerodt, M B T Hofferberth, M Russ, W Braun, M Walter, R Francis, B Lachmann, S Leonhardt, I H J Koh, R B Souza, A M C R P F Martins, J C F Vieira, A M A Liberatore, A Landaverde-López, N A Canedo-Castillo, A Esquivel-Chávez, P C Arvizu-Tachiquín, L A Sánchez-Hurtado, J A Baltazar-Torres, V Cardoso, A Krystopchuk, S Castro, L Melão, S Firmino, A Marreiros, C Granja, S Almaziad, A Kubbara, W Barnett, R Nakity, W Alamoudi, R Altook, T Tarazi, M Fida, F Safi, R Assaly, A Santini, M Milesi, T Maraffi, P Pugni, D T Andreis, M Cavenago, L Gattinoni, A Protti, G Perchiazzi, J B Borges, S Bayat, L Porra, L Broche, M Pellegrini, G Scaramuzzo, G Hedenstierna, A Larsson, M Pellegrini, G Hedenstierna, A Roneus, M Segelsjö, M C Vestito, A Larsson, G Perchiazzi, E Gremo, A Nyberg, M Castegren, A Pikwer, T Yoshida, D Engelberts, G Otulakowski, B Katira, M Post, N D Ferguson, L Brochard, M B P Amato, B P Kavanagh, N Koch, W Huber, J Hoellthaler, S Mair, V Phillip, R M Schmid, A Beitz, V Baladrón, F J Redondo Calvo, D Padilla, P Villarejo, R Villazala, A S Yuste, N Bejarano, R J Steenstra, H Banierink, J Hof, I C van der Horst, M W Nijsten, M Hoekstra, K Roedl, F Sterz, T Horvatits, K Horvatits, A Drolz, H Herkner, V Fuhrmann, M Kott, K Zitta, B Brandt, C Schildhauer, G Elke, L Hummitzsch, I Frerichs, N Weiler, M Albrecht, L Rey González, D Cabestrero Alonso, A Blandino Ortiz, R de Pablo Sánchez, J Higuera Lucas, K Roedl, F Sterz, A Drolz, K Horvatits, T Horvatits, H Herkner, V Fuhrmann, T Horvatits, A Drolz, K Roedl, K Rutter, A Ferlitsch, G Fauler, M Trauner, V Fuhrmann, T Horvatits, S Pischke, L Fischer, F Thaiss, M Koch, K Bangert, V Fuhrmann, S Kluge, A W Lohse, B Nashan, M Sterneck, S Faenza, A Siniscalchi, E Pierucci, E Mancini, D Ricci, C Gemelli, A Cuoghi, S Magnani, M Atti, F Sotos, J Cánovas, A López, A Burruezo, D Torres, M E Herrera-Gutierrez, J Barrueco-Francioni, D Arias-Verdú, R Lozano-Saez, G Quesada-Garcia, G Seller-Pérez, A Figueiredo, Y Anzola, R Pereira, L Bento, D Arias-Verdú, M Lai, M Deiana, J Barrueco-Francioni, M E Herrera-Gutierrez, G Seller-Perez, K Vardas, S Ilia, A Sertedaki, E Charmadari, C A Stratakis, E Briassouli, D Goukos, K Psarra, E Botoula, S Tsagarakis, E Mageira, C Routsi, S Nanas, G Briassoulis, A Boscolo, D Bertini, E Campello, V Lucchetta, E Piasentini, C M Radu, L Manesso, P Simioni, C Ori, H Su, Y M Lam, K Willis, V Pullar, R P Hubner, J L Tsang, L García de Guadiana-Romualdo, S Rebollo-Acebes, P Esteban-Torrella, R Jiménez-Sánchez, E Jiménez-Santos, A Ortín-Freire, A Hernando-Holgado, M D Albaladejo-Otón, L Coelho, L Rabello, J Salluh, I Martin-Loeches, A Rodriguez, S Nseir, P Póvoa, E Varis, V Pettilä, M Poukkanen, S Jacob, S Karlsson, A Perner, J Takala, E Wilkman, O H M Lundberg, L Bergenzaun, J Rydén, M Rosenqvist, O Melander, M S Chew, E Rodriguez-Ruiz, R Hernández Vaquero, A Lopez Lago, J L Garcia Allut, A Estany Gestal, M A Garcia Gonzalez, Y Kishihara, H Yasuda, S Rebollo, L García de Guadiana-Romualdo, R Jimenez, P Esteban Torrella, A Fernandez, S Sanchez, A Ortin, G Li Bassi, R Guillamat Prats, A Artigas, E Aguilera, D Marti, O T Ranzani, M Rigol, L Fernandez, M Ferrer, I Martin-Loeches, A Torres, V S Lanziotti, P Póvoa, L Pulcheri, M O Ribeiro, A P Barbosa, J R Lapa E Silva, M Soares, J I F Salluh, I Palacios Garcia, A Diaz Martin, M Gil Marqués, A Puppo Moreno, A Gutierrez Pizarraya, J Pachón Diaz, M Pachón Ibañez, Y Smani, M Mc Connell, L A Zhang, R S Parker, I Banerjee, G Clermont, E Norberg, J Oras, A Cuisinier, C Maufrais, J F Payen, S Nottin, G Walther, P Bouzat, S Arib, F Bilotta, R Badenes, F Rubulotta, S Mirek, I A Crippa, B Monfort, E Stazi, A Lozano Roig, J Creteur, F S Taccone, S Magnoni, M Marando, S Pifferi, V Conte, F Ortolano, M Carbonara, G Bertani, E Scola, M Cadioli, F Triulzi, A Colombo, N Stocchetti, H B Rotzel, A Serrano Lázaro, D Aguillón Prada, M Rodriguez Guimillo, C Sanchís Piqueras, J Romero Guia, M García Simon, A Mesejo Arizmendi, A Carratalá, S El Maraghi, A Yehia, M Bakry, A Shoman, F N Backes, M M Bianchin, S R R Vieira, A de Souza, A N Backes, C Klein, M S Kalaiselvan, M K Renuka, A S Arunkumar, A Lozano, O Lheureux, R Badenes, J L Vincent, J Creteur, F S Taccone, C Gallaher, S Cattlin, S Gordon, J Picard, V Fontana, O Bond, L Nobile, J L Vincent, J Creteur, F S Taccone, S Mrozek, L Delamarre, F Capilla, T Al-Saati, O Fourcade, T Geeraerts, A M Dominguez-Berrot, M Gonzalez-Vaquero, M E Vallejo-Pascual, D Gupta, B D Ivory, M Chopra, J McCarthy, C L Felderhof, C MacNeil, F Rubulotta, P Waldauf, M Maggiorini, F Duska, R R L Fumis, J M Vieira Junior, G Amarante, A Skorko, S Sanders, J Aron, R J Kroll, C Redfearn, P Krishnan, J E Khalil, F Kovari, N Kongpolprom, V Gulia, E Lourenço, L Melão, C Duro, G Baptista, A Alves, B Arminda, M 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Besch, A Perrotti, M Puyraveau, L Carteron, M Baltres, E Samain, S Chocron, S Pili-Floury, E P Plata-Menchaca, J Sabater-Riera, M Estruch, E Boza, F Sbraga, J Toscana-Fernández, E Bruguera-Pellicer, J Ordoñez-Llanos, X L Pérez-Fernández, P Cavaleiro, A Tralhão, M Arrigo, J-P Lopes, M Lebrun, B Cholley, J L PerezVela, H MarinMateos, J J Jimenez Rivera, M A Alcala Llorente, B Gonzalez De Marcos, F J Gonzalez Fernandez, C Garcia Laborda, D Fernandez Zamora, J C Lopez Delgado, C Imperiali, D Berbel-Franco, M Dastis, G Moreno-Gonzalez, J Perez-Sanchez, I Romera-Peregrina, R Abellan-Lencina, A Martinez-Pascual, V Fuentes-Mila, M Gonzalez-Romero, J Górka, K Górka, T Iwaniec, M Frołow, K Polok, J Fronczek, M Kózka, J Musiał, W Szczeklik, A González Pérez, P Florez Ordoñez, A Giribet, M A Alonso Cuervo, R Alonso Cuervo, M A Rodriguez Esteban, L Iglesias Fraile, C Ponte Mittelbrum, G Muñiz Albaiceta, F Ampatzidou, M Sileli, G Kehagioglou, A Madesis, T Karaiskos, C Moursia, H Maleoglou, K Leleki, 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la Torre, E Torres, A Alonso, C Velayos, T Saldaña, A Escribá, J Grip, R Kölegård, P Sundblad, O Rooyackers, Ben Naser, F Jaziri, A Ben Jazia, M Barghouth, O Hentati, W Skouri, M El Euch, M Mahfoudhi, S Turki, K Ben Abdelghni, Ben Abdallah, B N M Maha, J Cánovas, F Sotos, A López, M Lorente, A Burruezo, D Torres, K Polok, A Włudarczyk, J Górka, A Hałek, J Musiał, W Szczeklik, A Ben Jazia, F Jaziri, M Bargouth, M Bennasr, S Turki, K Ben Abdelghani, T Ben Abdallah, H J de Grooth, I L Geenen, J J Parienti, H M Oudemans-van Straaten, H P Shum, H S King, K C Chan, W W Yan, J Gonzalez Londoño, C Lorencio Cardenas, M Morales Pedrosa, C Murcia Gubianas, C Fuster Bertolin, N Vila Batllori, J M Sirvent, K Wykes, J Jack, P Morgan, A Mukhopadhyay, H Y Chan, Y Kowitlawakul, D Remani, C S F Leong, C J Henry, Z A Puthucheary, N Mendsaikhan, T Begzjav, G Lundeg, M Dünser, E D Valenzuela Espinoza, S P Welsh, M F Motta, E Guerra, M C L Zerpa, F Zechner, M Furche, F Berdaguer, P N Rubatto Birri, A Risso-Vazquez, A Dubin, F D Masevicius, D Greaney, A Magee, G Fitzpatrick, R G Lugo-Cob, L A Sánchez-Hurtado, P C Arvizu-Tachiquín, B C Tejeda-Huezo, A A Cano-Oviedo, J A Baltazar-Torres, M S Aydogan, T Togal, A Taha, H Z Chai, C Kam, S S Yang Razali, V Sivasamy, L Y Kuan, V Poulose, M A Lopez Morales, S Castro, T Pires, L Melão, A Krystopchuk, I Pereira, C Granja, L U Taniguchi, E M C Pires, J M Vieira, L C P Azevedo
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27486177/evaluating-acetate-metabolism-for-imaging-and-targeting-in-multiple-myeloma
#7
Francesca Fontana, Xia Ge, Xinming Su, Deep Hathi, Jingyu Xiang, Simone Cenci, Roberto Civitelli, Kooresh I Shoghi, Walter J Akers, Andre D'avignon, Katherine N Weilbaecher, Monica Shokeen
PURPOSE: We hypothesized that in multiple myeloma cells (MMC), high membrane biosynthesis will induce acetate uptake in vitro and in vivo Here, we studied acetate metabolism and targeting in MMC in vitro and tested the efficacy of (11)C-acetate-positron emission tomography (PET) to detect and quantitatively image myeloma treatment response in vivo EXPERIMENTAL DESIGN: Acetate fate tracking using (13)C-edited-(1)H NMR (nuclear magnetic resonance) was performed to study in vitro acetate uptake and metabolism in MMC...
January 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#8
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27165152/vastus-lateralis-maximum-force-generating-potential-occurs-at-optimal-fascicle-length-regardless-of-activation-level
#9
Heiliane de Brito Fontana, Walter Herzog
PURPOSE: Despite the fact that everyday movements are hardly ever performed with muscles contracting maximally, our understanding of the force-length relationship is mostly based on in vitro studies using maximal activation. In this study, the in vivo submaximal and maximal force-length relationships of vastus-lateralis were investigated. Force-length relationships were obtained based on maximal and submaximal levels of force and, also, on EMG activation. METHODS: Nine subjects performed isometric knee extensor contractions at ten knee angles (80°-170°)...
June 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/26814965/the-temporal-scaling-of-caenorhabditis-elegans-ageing
#10
Nicholas Stroustrup, Winston E Anthony, Zachary M Nash, Vivek Gowda, Adam Gomez, Isaac F López-Moyado, Javier Apfeld, Walter Fontana
The process of ageing makes death increasingly likely, involving a random aspect that produces a wide distribution of lifespan even in homogeneous populations. The study of this stochastic behaviour may link molecular mechanisms to the ageing process that determines lifespan. Here, by collecting high-precision mortality statistics from large populations, we observe that interventions as diverse as changes in diet, temperature, exposure to oxidative stress, and disruption of genes including the heat shock factor hsf-1, the hypoxia-inducible factor hif-1, and the insulin/IGF-1 pathway components daf-2, age-1, and daf-16 all alter lifespan distributions by an apparent stretching or shrinking of time...
February 4, 2016: Nature
https://www.readbyqxmd.com/read/26426623/efficacy-of-anakinra-in-refractory-adult-onset-still-s-disease-multicenter-study-of-41-patients-and-literature-review
#11
MULTICENTER STUDY
Francisco Ortiz-Sanjuán, Ricardo Blanco, Leyre Riancho-Zarrabeitia, Santos Castañeda, Alejandro Olivé, Anne Riveros, María L Velloso-Feijoo, Javier Narváez, Inmaculada Jiménez-Moleón, Olga Maiz-Alonso, Carmen Ordóñez, José A Bernal, María V Hernández, Walter A Sifuentes-Giraldo, Catalina Gómez-Arango, Eva Galíndez-Agirregoikoa, Juan Blanco-Madrigal, Vera Ortiz-Santamaria, Jordi del Blanco-Barnusell, Juan R De Dios, Mireia Moreno, Jordi Fiter, Marina de los Riscos, Patricia Carreira, María J Rodriguez-Valls, M Carmen González-Vela, Vanesa Calvo-Río, Javier Loricera, Natalia Palmou-Fontana, Trinitario Pina, Javier Llorca, Miguel A González-Gay
Adult-onset Still's disease (AOSD) is often refractory to standard therapy. Anakinra (ANK), an interleukin-1 receptor antagonist, has demonstrated efficacy in single cases and small series of AOSD. We assessed the efficacy of ANK in a series of AOSD patients. Multicenter retrospective open-label study. ANK was used due to lack of efficacy to standard synthetic immunosuppressive drugs and in some cases also to at least 1 biologic agent. Forty-one patients (26 women/15 men) were recruited. They had a mean age of 34...
September 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26238119/changes-in-and-impact-of-the-death-review-process-in-the-prostate-lung-colorectal-and-ovarian-plco-cancer-screening-trial
#12
REVIEW
Anthony B Miller, Ronald Feld, Robert Fontana, John K Gohagan, Ismail Jatoi, Walter Lawrence, Amy Miller, Philip C ProroK, Ashwani Rajput, Morris Sherman, Gilbert Welch, Patrick Wright, Susan Yurgalevitch, Peter Albertsen
Death review was conducted for the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial to avoid the biases associated with causes of death entered on death certificates. An algorithm selected deaths for review. Records on diagnosis and terminal illness were perused in the coordinating center and by the chair of the death review committee (DRC). Identifying information and randomization arm was removed. Three reviewers independently determined the cause of death. Disagreement was resolved at a meeting of the DRC...
2015: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/26169209/how-much-are-biosimilars-used-in-clinical-practice-a-retrospective-italian-population-based-study-of-erythropoiesis-stimulating-agents-in-the-years-2009-2013
#13
MULTICENTER STUDY
Ylenia Ingrasciotta, Francesco Giorgianni, Jenny Bolcato, Alessandro Chinellato, Roberta Pirolo, Daniele Ugo Tari, Chiara Troncone, Andrea Fontana, Valentina Ientile, Rosa Gini, Domenico Santoro, Mariacarmela Santarpia, Armando Genazzani, Ilaria Uomo, Maurizio Pastorello, Walter Sebastiano Pollina Addario, Salvatore Scondotto, Pasquale Cananzi, Achille Patrizio Caputi, Gianluca Trifirò
PURPOSE: To explore the prescription patterns of erythropoiesis-stimulating agents (ESAs) in four large Italian geographic areas, where different health policy interventions to promote biosimilar use in routine care are undertaken. METHODS: A retrospective drug utilization study was conducted during the years 2009-2013. The data sources were the administrative databases of the Tuscany region and of the Caserta, Palermo, and Treviso Local Health Units (LHUs). The characteristics, prevalence, and switching patterns of different ESAs (biosimilars and reference products), stratified by indication for use, were calculated over time and across centers...
August 2015: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/25262602/regulated-spatial-organization-and-sensitivity-of-cytosolic-protein-oxidation-in-caenorhabditis-elegans
#14
Catalina Romero-Aristizabal, Debora S Marks, Walter Fontana, Javier Apfeld
Cells adjust their behaviour in response to redox events by regulating protein activity through the reversible formation of disulfide bridges between cysteine thiols. However, the spatial and temporal control of these modifications remains poorly understood in multicellular organisms. Here we measured the protein thiol-disulfide balance in live Caenorhabditis elegans using a genetically encoded redox sensor and found that it is specific to tissues and is patterned spatially within a tissue. Insulin signalling regulates the sensor's oxidation at both of these levels...
2014: Nature Communications
https://www.readbyqxmd.com/read/25130178/in-vivo-vastus-lateralis-force-velocity-relationship-at-the-fascicle-and-muscle-tendon-unit-level
#15
Heiliane de Brito Fontana, Helio Roesler, Walter Herzog
The force velocity relationship of in vivo human muscle fibers has often been derived from the torque-angular speed relationship during maximal voluntary isokinetic contractions. However, the assumption of a close association between joint performance and muscle mechanics is questionable. We aimed to determine the relationship between knee extension angular speeds, vastus lateralis fascicle and muscle tendon unit (MTU) shortening speeds, and maximal knee extensor force for the entire range of knee joint movement, for the isokinetic range, and for the ranges before, after and at peak torque occurrence, with different commonly used pre-loading conditions...
December 2014: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/25081974/the-evolving-role-of-neurological-imaging-in-neuro-oncology
#16
REVIEW
E J Fontana, T Benzinger, C Cobbs, J Henson, S J Fouke
Neuroimaging has played a critical role in the management of patients with neurological disease, since the first ventriculogram was performed in 1918 by Walter Dandy (Mezger et al. Langenbecks Arch Surg 398(4):501-514, 2013). Over the last century, technology has evolved significantly, and within the last decade, the role of imaging in the management of patients with neuro-oncologic disease has shifted from a tool for gross identification of intracranial pathology, to an integral part of real-time neurological surgery...
September 2014: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/24941104/preparation-and-layer-by-layer-solution-deposition-of-cu-in-ga-o2-nanoparticles-with-conversion-to-cu-in-ga-s2-films
#17
Walter J Dressick, Carissa M Soto, Jake Fontana, Colin C Baker, Jason D Myers, Jesse A Frantz, Woohong Kim
We present a method of Cu(In,Ga)S2 (CIGS) thin film formation via conversion of layer-by-layer (LbL) assembled Cu-In-Ga oxide (CIGO) nanoparticles and polyelectrolytes. CIGO nanoparticles were created via a novel flame-spray pyrolysis method using metal nitrate precursors, subsequently coated with polyallylamine (PAH), and dispersed in aqueous solution. Multilayer films were assembled by alternately dipping quartz, Si, and/or Mo substrates into a solution of either polydopamine (PDA) or polystyrenesulfonate (PSS) and then in the CIGO-PAH dispersion to fabricate films as thick as 1-2 microns...
2014: PloS One
https://www.readbyqxmd.com/read/24733721/virus-templated-plasmonic-nanoclusters-with-icosahedral-symmetry-via-directed-self-assembly
#18
Jake Fontana, Walter J Dressick, Jamie Phelps, John E Johnson, Ronald W Rendell, Travian Sampson, Banahalli R Ratna, Carissa M Soto
The assembly of plasmonic nanoparticles with precise spatial and orientational order may lead to structures with new electromagnetic properties at optical frequencies. The directed self-assembly method presented controls the interparticle-spacing and symmetry of the resulting nanometer-sized elements in solution. The self-assembly of three-dimensional (3D), icosahedral plasmonic nanosclusters (NCs) with resonances at visible wavelengths is demonstrated experimentally. The ideal NCs consist of twelve gold (Au) nanospheres (NSs) attached to thiol groups at predefined locations on the surface of a genetically engineered cowpea mosaic virus with icosahedral symmetry...
August 13, 2014: Small
https://www.readbyqxmd.com/read/24675767/an-insulin-to-insulin-regulatory-network-orchestrates-phenotypic-specificity-in-development-and-physiology
#19
Diana Andrea Fernandes de Abreu, Antonio Caballero, Pascal Fardel, Nicholas Stroustrup, Zhunan Chen, Kyunghwa Lee, William D Keyes, Zachary M Nash, Isaac F López-Moyado, Federico Vaggi, Astrid Cornils, Martin Regenass, Anca Neagu, Ivan Ostojic, Chang Liu, Yongmin Cho, Deniz Sifoglu, Yu Shen, Walter Fontana, Hang Lu, Attila Csikasz-Nagy, Coleen T Murphy, Adam Antebi, Eric Blanc, Javier Apfeld, Yun Zhang, Joy Alcedo, Queelim Ch'ng
Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse processes, including development, reproduction, longevity and several specific stress responses. Our systematic studies identify an ILP-based combinatorial code for these phenotypes characterized by substantial functional specificity and diversity rather than global redundancy. Notably, we show that ILPs regulate each other transcriptionally, uncovering an ILP-to-ILP regulatory network that underlies the combinatorial phenotypic coding by the ILP family...
March 2014: PLoS Genetics
https://www.readbyqxmd.com/read/23912381/experimental-hypothyroidism-increases-apoptosis-in-dimethylbenzanthracene-induced-mammary-tumors
#20
Constanza Matilde López-Fontana, Corina Verónica Sasso, María Eugenia Maselli, Flavia Eliana Santiano, Silvana Noemí Semino, Fernando Darío Cuello Carrión, Graciela Alma Jahn, Rubén Walter Carón
Epidemiological and in vitro data have not provided conclusive evidence concerning the involvement of thyroid hormones (THs) on mammary carcinogenesis. We used an in vivo model to assess the relationship between THs, adipose tissue and breast cancer development. Female Sprague‑Dawley rats were treated with a dose of 7,12-dimethylbenz(a)anthracene (15 mg/rat) at 55 days of age and were then divided into four experimental groups: hypothyroid rats (HypoT, 0.01% 6-N-propyl-2-thiouracil in drinking water), untreated control (EUT); hyperthyroid rats (HyperT, 0...
October 2013: Oncology Reports
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