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JOURNAL ARTICLE
Arpamas Vachiraarunwong, Min Gi, Tohru Kiyono, Shugo Suzuki, Masaki Fujioka, Guiyu Qiu, Runjie Guo, Tomoki Yamamoto, Anna Kakehashi, Masayuki Shiota, Hideki Wanibuchi
Arsenic is highly toxic to the human bladder. In the present study, we established a human bladder epithelial cell line that closely mimics normal human bladder epithelial cells by immortalizing primary uroplakin 1B-positive human bladder epithelial cells with human telomerase reverse transcriptase (HBladEC-T). The uroplakin 1B-positive human bladder epithelial cell line was then used to evaluate the toxicity of seven arsenicals (iAsV , iAsIII , MMAV , MMAIII , DMAV , DMAIII , and DMMTAV ). The cellular uptake and metabolism of each arsenical was different...
April 17, 2024: Archives of Toxicology
#2
JOURNAL ARTICLE
Shigeru Kamimura, Yuta Mitobe, Kazuki Nakamura, Kenichiro Matsuda, Yonehiro Kanemura, Masafumi Kanoto, Mitsuru Futakuchi, Yukihiko Sonoda
BACKGROUND: Although mutations in telomerase reverse transcriptase ( TERT ) promoter ( TERT p) are the most common alterations in glioblastoma (GBM), predicting TERT p mutation status by preoperative imaging is difficult. We determined whether tumour-surrounding hyperintense lesions on fluid-attenuated inversion recovery (FLAIR) were superior to those of contrast-enhanced lesions (CELs) in assessing TERT p mutation status using magnetic resonance imaging (MRI). METHODS: This retrospective study included 114 consecutive patients with primary isocitrate dehydrogenase (IDH)-wild-type GBM...
2024: Surgical Neurology International
#3
JOURNAL ARTICLE
Xingyuan Wang, Jing Yang, Dechao Li, Lichen Teng, Yongsheng Chen, Jie Meng, Chen Yang, Zhihao Yin, Changfu Li
Renal cell carcinoma (RCC) is the most common kidney cancer with high mortality rate. Pazopanib has been approved for the treatment of RCC. However, the underlying mechanism is not clear. Here, we report a novel finding by showing that treatment with Pazopanib could promote cellular senescence of the human RCC cell line ACHN. Cells were stimulated with 5, 10, and 20 μM Pazopanib, respectively. Cellular senescence was measured using senescence-associated β-galactosidase (SA-β-Gal) staining...
April 2024: Journal of Biochemical and Molecular Toxicology
#4
JOURNAL ARTICLE
David G Nickens, Zhitong Feng, Jiangchuan Shen, Spencer J Gray, Robert H Simmons, Hengyao Niu, Matthew L Bochman
Telomerase is the enzyme that lengthens telomeres and is tightly regulated by a variety of means to maintain genome integrity. Several DNA helicases function at telomeres, and we previously found that the Saccharomyces cerevisiae helicases Hrq1 and Pif1 directly regulate telomerase. To extend these findings, we are investigating the interplay between helicases, single-stranded DNA (ssDNA) binding proteins (ssBPs), and telomerase. The yeast ssBPs Cdc13 and RPA differentially affect Hrq1 and Pif1 helicase activity, and experiments to measure helicase disruption of Cdc13/ssDNA complexes instead revealed that Cdc13 can exchange between substrates...
April 13, 2024: Nucleic Acids Research
#5
REVIEW
Stephen S Prime, Piotr Darski, Keith D Hunter, Nicola Cirillo, E Kenneth Parkinson
We explore the possibility that defects in genes associated with the response and repair of DNA double strand breaks predispose oral potentially malignant disorders (OPMD) to undergo malignant transformation to oral squamous cell carcinoma (OSCC). Defects in the homologous recombination/Fanconi anemia (HR/FA), but not in the non-homologous end joining, causes the DNA repair pathway to appear to be consistent with features of familial conditions that are predisposed to OSCC (FA, Bloom's syndrome, Ataxia Telangiectasia); this is true for OSCC that occurs in young patients, sometimes with little/no exposure to classical risk factors...
April 7, 2024: International Journal of Molecular Sciences
#6
JOURNAL ARTICLE
Ailin Zou, Tingting Xiao, Boyu Chi, Yu Wang, Lipeng Mao, Dabei Cai, Qingqing Gu, Qianwen Chen, Qingjie Wang, Yuan Ji, Ling Sun
BACKGROUND: Cardiac repair remains a thorny issue for survivors of acute myocardial infarction (AMI), due to the regenerative inertia of myocardial cells. Cell-free therapies, such as exosome transplantation, have become a potential strategy for myocardial injury. The aim of this study was to investigate the role of engineered exosomes in overexpressing Growth Differentiation Factor-15 (GDF-15) (GDF15-EVs) after myocardial injury, and their molecular mechanisms in cardiac repair. METHODS: H9C2 cells were transfected with GDF-15 lentivirus or negative control...
2024: International Journal of Nanomedicine
#7
JOURNAL ARTICLE
Jun Seob Lee, So Young Lee, Hee Seung Chin, Na Rae Kim, Ji Won Jung
PURPOSE: To compare the microstructure of the corneal endothelial transition zone in different laboratory animals. METHODS: Flat-mount corneas of rabbits, rats, and mice were stained with Alizarin Red S (ARS) and observed using scanning electron microscopy (SEM). The progenitor cell markers p75 neurotrophin receptor (p75NTR), SRY-box transcription factor 9 (SOX9), leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5), telomerase reverse transcriptase (TERT), and proliferation marker Ki -67 were examined in the flat-mounted corneas of three laboratory animals using immunofluorescence microscopy...
2024: Molecular Vision
#8
REVIEW
Pramit Kumar Ghosh, Maddila Jagapathi Rao, Chandra Lekha Putta, Sandipan Ray, Aravind Kumar Rengan
Cancer represents a complex disease category defined by the unregulated proliferation and dissemination of anomalous cells within the human body. According to the GLOBOCAN 2020 report, the year 2020 witnessed the diagnosis of approximately 19.3 million new cases of cancer and 10.0 million individuals succumbed to the disease. A typical cell eventually becomes cancerous because of a long-term buildup of genetic instability and replicative immortality. Telomerase is a crucial regulator of cancer progression as it induces replicative immortality...
April 10, 2024: Biomaterials Science
#9
JOURNAL ARTICLE
Rishi R Lulla, Allen Buxton, Mark D Krailo, Margot A Lazow, Daniel R Boue, James L Leach, Tong Lin, James I Geller, Shiva Senthil Kumar, Marina N Nikiforova, Uma Chandran, Sachin S Jogal, Marvin D Nelson, Arzu Onar-Thomas, Daphne A Haas-Kogan, Kenneth J Cohen, Mark W Kieran, Amar Gajjar, Rachid Drissi, Ian F Pollack, Maryam Fouladi
BACKGROUND: Outcomes for children with high-grade gliomas (HGG) remain poor. This multicenter phase II trial evaluated whether concurrent use of vorinostat or bevacizumab with focal radiotherapy (RT) improved 1-year event-free survival (EFS) compared to temozolomide in children with newly diagnosed HGG who received maintenance temozolomide and bevacizumab. METHODS: Patients ≥ 3 and < 22 years with localized, non-brainstem HGG were randomized to receive RT (dose 54-59...
2024: Neuro-oncology advances
#10
REVIEW
Songting Shou, Yuanliang Li, Jiaqin Chen, Xing Zhang, Chuanlong Zhang, Xiaochen Jiang, Fudong Liu, Li Yi, Xiyuan Zhang, En Geer, Zhenqing Pu, Bo Pang
Telomerase is associated with cellular aging, and its presence limits cellular lifespan. Telomerase by preventing telomere shortening can extend the number of cell divisions for cancer cells. In adult pancreatic cells, telomeres gradually shorten, while in precancerous lesions of cancer, telomeres in cells are usually significantly shortened. At this time, telomerase is still in an inactive state, and it is not until before and after the onset of cancer that telomerase is reactivated, causing cancer cells to proliferate...
April 9, 2024: Cancer Gene Therapy
#11
JOURNAL ARTICLE
Abdullah Karadağ, Ebubekir Dirican, Çağdaş Gökhun Özmerdiven, Ata Özen, Semih Ayan, Selda Kabadere
Prostate cancer (PC) is the most frequent cancer in males, as well as the second highest cause of cancer-related deaths in men. Differences in expression levels of miRNAs were linked with prostat cancer pathogenesis. qPCR was used to evaluate the expression of miR-130b-3p and miR-375 in Benign Prostate Hyperplasia (BPH ( n = 20) and PC ( n = 22, pre- and post-operative) patients plasma. Relative telomere lengths (RLTs) in genomic DNA isolated from plasma were measured with qPCR, and telomerase activity analyzed by the ELISA method...
April 9, 2024: Nucleosides, Nucleotides & Nucleic Acids
#12
JOURNAL ARTICLE
Lucie Bozděchová, Anna Rudolfová, Kateřina Hanáková, Miloslava Fojtová, Jiří Fajkus
The current repertoire of methods available for studying RNA-protein interactions in plants is somewhat limited. Employing an RNA-centric approach, particularly with less abundant RNAs, presents various challenges. Many of the existing methods were initially designed for different model systems, with their application in plants receiving limited attention thus far. The Comprehensive Identification of RNA-Binding Proteins by Mass Spectrometry (ChIRP-MS) technique, initially developed for mammalian cells, has been adapted in this study for application in Arabidopsis thaliana ...
March 15, 2024: Plants (Basel, Switzerland)
#13
JOURNAL ARTICLE
Mohamed Ali Alabiad, Warda M M Said, Amal M A Adim, Mohammed Alorini, Amany Mohamed Shalaby, Walaa Samy, Shereen Elshorbagy, Doaa Mandour, Ibrahim Mohamed Saber, Amar Ibrahim Omar Yahia, Dina Ahmed Khairy
BACKGROUND: Human papillomavirus (HPV)-related multi phenotypic sinonasal carcinoma (HMSC) is a recently described tumor subtype with an unknown prognosis, often misdiagnosed with other sinonasal carcinomas, and associated with high-risk HPV (HR-HPV). The present study aimed to evaluate the expression of vascular endothelial growth factor (VEGF), Bcl-2-associated X protein (BAX), epidermal growth factor receptors (EGFR), ProExTM C, and human telomerase reverse transcriptase (hTERT) and assess their association with survival and clinicopathological characteristics...
March 2024: Iranian Journal of Medical Sciences
#14
REVIEW
Francisco Alejandro Lagunas-Rangel
Giardia duodenalis, the protozoan responsible for giardiasis, is a significant contributor to millions of diarrheal diseases worldwide. Despite the availability of treatments for this parasitic infection, therapeutic failures are alarmingly frequent. Thus, there is a clear need to identify new therapeutic targets. Giardia telomeres were previously identified, but our understanding of these structures and the critical role played by Giardia telomerase in maintaining genomic stability and its influence on cellular processes remains limited...
April 8, 2024: Parasitology Research
#15
JOURNAL ARTICLE
Aman Kumar, Yosuke Nagasaka, Vinodhini Jayananthan, Asmaa Zidan, Tyler Heisler-Taylor, Jayakrishna Ambati, Shigeo Tamiya, Nagaraj Kerur
Choroidal neovascularization (CNV) is the principal driver of blindness in neovascular age-related macular degeneration (nvAMD). Increased activity of telomerase, has been associated with endothelial cell proliferation, survival, migration, and invasion in the context of tumor angiogenesis. Expanding on this knowledge, we investigated the role of telomerase in the development of CNV in mouse model. We observed increased gene expression and activity of telomerase in mouse CNV. Genetic deficiency of the telomerase components, telomerase reverse transcriptase (Tert) and telomerase RNA component (Terc) suppressed laser-induced CNV in mice...
April 4, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
#16
JOURNAL ARTICLE
Yazan Madanat, Michael R Savona, Mikkael A Sekeres, Uwe Platzbecker, Valeria Santini, Pierre Fenaux, Maria Diez-Campelo, David Valcárcel, Tymara Berry, Souria Dougherty, Sheetal Shah, Libo Sun, Ying Wan, Fei Huang, Shyamala Navada, Rami S Komrokji, Amer M Zeidan
No abstract text is available yet for this article.
April 5, 2024: Journal of the National Comprehensive Cancer Network: JNCCN
#17
JOURNAL ARTICLE
Hai-Yang Li, Lin-Lin Zheng, Nan Hu, Zhi-Hao Wang, Chang-Cheng Tao, Ya-Ru Wang, Yue Liu, Zulihumaer Aizimuaji, Hong-Wei Wang, Rui-Qi Zheng, Ting Xiao, Wei-Qi Rong
BACKGROUND: As a critical early event in hepatocellular carcinogenesis, telomerase activation might be a promising and critical biomarker for hepatocellular carcinoma (HCC) patients, and its function in the genesis and treatment of HCC has gained much attention over the past two decades. AIM: To perform a bibliometric analysis to systematically assess the current state of research on HCC-related telomerase. METHODS: The Web of Science Core Collection and PubMed were systematically searched to retrieve publications pertaining to HCC/telomerase limited to "articles" and "reviews" published in English...
March 7, 2024: World Journal of Gastroenterology: WJG
#18
EDITORIAL
Rajendra Prasad, Gurjit Kaur
No abstract text is available yet for this article.
April 2024: Indian Journal of Clinical Biochemistry: IJCB
#19
JOURNAL ARTICLE
Ayaka Sako, Michiko Matsuse, Vladimir Saenko, Aya Tanaka, Ryota Otsubo, Michi Morita, Sayaka Kuba, Eijun Nishihara, Keiji Suzuki, Tomoo Ogi, Atsushi Kawakami, Norisato Mitsutake
CONTEXT: Telomerase reverse transcriptase promoter (TERT-p) mutations, which upregulate TERT expression, are strongly associated with tumor aggressiveness and worse prognosis in papillary thyroid carcinomas (PTCs). TERT expression is also observed in a proportion of PTCs without TERT-p mutations, but such tumors show less aggressiveness and better prognosis compared with TERT-p mutation-positive tumors. OBJECTIVE: TERT has multiple splicing variants whose relationships with the TERT-p status and clinicopathological characteristics remain poorly understood...
April 5, 2024: Journal of Clinical Endocrinology and Metabolism
#20
JOURNAL ARTICLE
Alexandre Brudon, Marie Legendre, Arthur Mageau, Julien Bermudez, Philippe Bonniaud, Diane Bouvry, Jacques Cadranel, Aurélie Cazes, Bruno Crestani, Tristan Dégot, Céline Delestrain, Rémi Diesler, Ralph Epaud, Quentin Philippot, Nathalie Theou-Anton, Caroline Kannengiesser, Ibrahima Ba, Marie-Pierre Debray, Pascale Fanen, Efrosine Manali, Spyros Papiris, Nadia Nathan, Serge Amselem, Antoine Gondouin, Anne Guillaumot, Claire Andréjak, Stephane Jouneau, Guillaume Beltramo, Yurdagul Uzunhan, François Galodé, Virginie Westeel, Anas Mehdaoui, Sandrine Hirschi, Sylvie Leroy, Sylvain Marchand-Adam, Hilario Nunes, Clément Picard, Grégoire Prevot, Martine Reynaud-Gaubert, Paul De Vuyst, Lidwine Wemeau, Gautier Defossez, Gérard Zalcman, Vincent Cottin, Raphael Borie
RATIONALE: Several rare surfactant-related genes variants associated with interstitial lung disease are suspected to be associated with lung cancer, but data are missing. OBJECTIVES: We aimed to study the epidemiology and phenotype of lung cancer in an international cohort of surfactant-related gene (SRG) variant carriers. METHODS: We conducted a cross-sectional study of all adults with SRG variants in the OrphaLung network and compared lung cancer risk with telomerase-related gene (TRG) variant carriers...
April 4, 2024: European Respiratory Journal
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