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Cynthia Kenyon

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https://www.readbyqxmd.com/read/29017283/reduced-severity-of-pertussis-in-persons-with-age-appropriate-pertussis-vaccination-united-states-2010-2012
#1
Lucy A McNamara, Tami Skoff, Amanda Faulkner, Lisa Miller, Kathy Kudish, Cynthia Kenyon, Marisa Bargsten, Shelley Zansky, Amy D Sullivan, Stacey Martin, Elizabeth Briere
Background: In 2012, >48000 pertussis cases were reported in the United States. Many cases occurred in vaccinated persons, showing that pertussis vaccination does not prevent all pertussis cases. However, pertussis vaccination may have an impact on disease severity. Methods: We analyzed data on probable and confirmed pertussis cases reported through Enhanced Pertussis Surveillance (Emerging Infections Program Network) between 2010 and 2012. Surveillance data were collected through physician and patient interview and vaccine registries...
September 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28704350/measles-outbreak-minnesota-april-may-2017
#2
Victoria Hall, Emily Banerjee, Cynthia Kenyon, Anna Strain, Jayne Griffith, Kathryn Como-Sabetti, Jennifer Heath, Lynn Bahta, Karen Martin, Melissa McMahon, Dave Johnson, Margaret Roddy, Denise Dunn, Kristen Ehresmann
On April 10, 2017, the Minnesota Department of Health (MDH) was notified about a suspected measles case. The patient was a hospitalized child aged 25 months who was evaluated for fever and rash, with onset on April 8. The child had no history of receipt of measles-mumps-rubella (MMR) vaccine and no travel history or known exposure to measles. On April 11, MDH received a report of a second hospitalized, unvaccinated child, aged 34 months, with an acute febrile rash illness with onset on April 10. The second patient's sibling, aged 19 months, who had also not received MMR vaccine, had similar symptoms, with rash onset on March 30...
July 14, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28423308/how-a-mutation-that-slows-aging-can-also-disproportionately-extend-end-of-life-decrepitude
#3
Katie Podshivalova, Rex A Kerr, Cynthia Kenyon
The goal of aging research is to extend healthy, active life. For decades, C. elegans daf-2 insulin/insulin-like growth factor 1 (IGF-1) receptor mutants have served as a model for extended lifespan and youthfulness. However, a recent report suggested that their longevity is associated with an undesirable phenotype: a disproportionately long period of decrepitude at the end of life. In the human population, such an outcome would be a burden to society, bringing into question the relevance of daf-2 mutants as a model for life extension...
April 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28378354/ecological-regime-shift-drives-declining-growth-rates-of-sea-turtles-throughout-the-west-atlantic
#4
Karen A Bjorndal, Alan B Bolten, Milani Chaloupka, Vincent S Saba, Cláudio Bellini, Maria A G Marcovaldi, Armando J B Santos, Luis Felipe Wurdig Bortolon, Anne B Meylan, Peter A Meylan, Jennifer Gray, Robert Hardy, Beth Brost, Michael Bresette, Jonathan C Gorham, Stephen Connett, Barbara Van Sciver Crouchley, Mike Dawson, Deborah Hayes, Carlos E Diez, Robert P van Dam, Sue Willis, Mabel Nava, Kristen M Hart, Michael S Cherkiss, Andrew G Crowder, Clayton Pollock, Zandy Hillis-Starr, Fernando A Muñoz Tenería, Roberto Herrera-Pavón, Vanessa Labrada-Martagón, Armando Lorences, Ana Negrete-Philippe, Margaret M Lamont, Allen M Foley, Rhonda Bailey, Raymond R Carthy, Russell Scarpino, Erin McMichael, Jane A Provancha, Annabelle Brooks, Adriana Jardim, Milagros López-Mendilaharsu, Daniel González-Paredes, Andrés Estrades, Alejandro Fallabrino, Gustavo Martínez-Souza, Gabriela M Vélez-Rubio, Ralf H Boulon, Jaime A Collazo, Robert Wershoven, Vicente Guzmán Hernández, Thomas B Stringell, Amdeep Sanghera, Peter B Richardson, Annette C Broderick, Quinton Phillips, Marta Calosso, John A B Claydon, Tasha L Metz, Amanda L Gordon, Andre M Landry, Donna J Shaver, Janice Blumenthal, Lucy Collyer, Brendan J Godley, Andrew McGowan, Matthew J Witt, Cathi L Campbell, Cynthia J Lagueux, Thomas L Bethel, Lory Kenyon
Somatic growth is an integrated, individual-based response to environmental conditions, especially in ectotherms. Growth dynamics of large, mobile animals are particularly useful as bio-indicators of environmental change at regional scales. We assembled growth rate data from throughout the West Atlantic for green turtles, Chelonia mydas, which are long-lived, highly migratory, primarily herbivorous mega-consumers that may migrate over hundreds to thousands of kilometers. Our dataset, the largest ever compiled for sea turtles, has 9690 growth increments from 30 sites from Bermuda to Uruguay from 1973 to 2015...
April 4, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28257500/pediatric-emergency-care-capacity-in-a-low-resource-setting-an-assessment-of-district-hospitals-in-rwanda
#5
Celestin Hategeka, Jean Shoveller, Lisine Tuyisenge, Cynthia Kenyon, David F Cechetto, Larry D Lynd
BACKGROUND: Health system strengthening is crucial to improving infant and child health outcomes in low-resource countries. While the knowledge related to improving newborn and child survival has advanced remarkably over the past few decades, many healthcare systems in such settings remain unable to effectively deliver pediatric advance life support management. With the introduction of the Emergency Triage, Assessment and Treatment plus Admission care (ETAT+)-a locally adapted pediatric advanced life support management program-in Rwandan district hospitals, we undertook this study to assess the extent to which these hospitals are prepared to provide this pediatric advanced life support management...
2017: PloS One
https://www.readbyqxmd.com/read/28033240/risk-factors-associated-with-bordetella-pertussis-among-infants-%C3%A2-4-months-of-age-in-the-pre-tdap-era-united-states-2002-2005
#6
Christine Robinette Curtis, Andrew L Baughman, Chas DeBolt, Susan Goodykoontz, Cynthia Kenyon, Barbara Watson, Pamela K Cassiday, Claudia Miller, Lucia C Pawloski, Maria-Lucia C Tondella, Kristine M Bisgard
BACKGROUND: In the United States, infants have the highest reported pertussis incidence and death rates. Improved understanding of infant risk factors is needed to optimize prevention strategies. METHODS: We prospectively enrolled infants ≤4 months of age with incident-confirmed pertussis from 4 sites during 2002-2005 (preceding pertussis antigen-containing vaccination recommendations for adolescents/adults); each case-patient was age and site matched with 2 control subjects...
August 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27453442/deep-proteome-analysis-identifies-age-related-processes-in-c-%C3%A2-elegans
#7
Vikram Narayan, Tony Ly, Ehsan Pourkarimi, Alejandro Brenes Murillo, Anton Gartner, Angus I Lamond, Cynthia Kenyon
Effective network analysis of protein data requires high-quality proteomic datasets. Here, we report a near doubling in coverage of the C. elegans adult proteome, identifying >11,000 proteins in total with ∼9,400 proteins reproducibly detected in three biological replicates. Using quantitative mass spectrometry, we identify proteins whose abundances vary with age, revealing a concerted downregulation of proteins involved in specific metabolic pathways and upregulation of cellular stress responses with advancing age...
August 2016: Cell Systems
https://www.readbyqxmd.com/read/27437426/public-health-s-role-in-response-to-an-outbreak-of-highly-pathogenic-avian-influenza-hpai-h5n2-minnesota-2015
#8
Karen Martin, Stacy Holzbauer, Tory Whitten, Carrie Klumb, Samantha Saunders, Melissa Mcmahon, Jayne Griffith, Anna Strain, Dave Boxrud, Cynthia Kenyon, Joni Scheftel
No abstract text is available yet for this article.
December 2015: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27304510/reversible-age-related-phenotypes-induced-during-larval-quiescence-in-c-elegans
#9
Antoine E Roux, Kelley Langhans, Walter Huynh, Cynthia Kenyon
Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and aging: mitochondrial fission, ROS production, protein aggregation, decreased proteotoxic-stress resistance, and at the organismal level, decline of mobility and high mortality. All signs of aging but one, the presence of protein aggregates, were reversed upon return to development induced by feeding...
June 14, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27140632/roles-for-ros-and-hydrogen-sulfide-in-the-longevity-response-to-germline-loss-in-caenorhabditis-elegans
#10
Yuehua Wei, Cynthia Kenyon
In Caenorhabditis elegans, removing germ cells slows aging and extends life. Here we show that transcription factors that extend life and confer protection to age-related protein-aggregation toxicity are activated early in adulthood in response to a burst of reactive oxygen species (ROS) and a shift in sulfur metabolism. Germline loss triggers H2S production, mitochondrial biogenesis, and a dynamic pattern of ROS in specific somatic tissues. A cytoskeletal protein, KRI-1, plays a key role in the generation of H2S and ROS...
May 17, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27030974/correlates-of-performance-of-healthcare-workers-in-emergency-triage-assessment-and-treatment-plus-admission-care-etat-course-in-rwanda-context-matters
#11
Celestin Hategekimana, Jeannie Shoveller, Lisine Tuyisenge, Cynthia Kenyon, David F Cechetto, Larry D Lynd
BACKGROUND: The Emergency, Triage, Assessment and Treatment plus Admission care (ETAT+) course, a comprehensive advanced pediatric life support course, was introduced in Rwanda in 2010 to facilitate the achievement of the fourth Millennium Development Goal. The impact of the course on improving healthcare workers (HCWs) knowledge and practical skills related to providing emergency care to severely ill newborns and children in Rwanda has not been studied. OBJECTIVE: To evaluate the impact of the ETAT+ course on HCWs knowledge and practical skills, and to identify factors associated with greater improvement in knowledge and skills...
2016: PloS One
https://www.readbyqxmd.com/read/26552604/micro-proteomics-with-iterative-data-analysis-proteome-analysis-in-c-elegans-at-the-single-worm-level
#12
Dalila Bensaddek, Vikram Narayan, Armel Nicolas, Alejandro Brenes Murillo, Anton Gartner, Cynthia J Kenyon, Angus I Lamond
Proteomics studies typically analyze proteins at a population level, using extracts prepared from tens of thousands to millions of cells. The resulting measurements correspond to average values across the cell population and can mask considerable variation in protein expression and function between individual cells or organisms. Here, we report the development of micro-proteomics for the analysis of Caenorhabditis elegans, a eukaryote composed of 959 somatic cells and ∼1500 germ cells, measuring the worm proteome at a single organism level to a depth of ∼3000 proteins...
February 2016: Proteomics
https://www.readbyqxmd.com/read/26347437/sources-of-infant-pertussis-infection-in-the-united-states
#13
Tami H Skoff, Cynthia Kenyon, Noelle Cocoros, Juventila Liko, Lisa Miller, Kathy Kudish, Joan Baumbach, Shelley Zansky, Amanda Faulkner, Stacey W Martin
BACKGROUND: Pertussis is poorly controlled, with the highest rates of morbidity and mortality among infants. Although the source of infant pertussis is often unknown, when identified, mothers have historically been the most common reservoir of transmission. Despite high vaccination coverage, disease incidence has been increasing. We examined whether infant source of infection (SOI) has changed in the United States in light of the changing epidemiology. METHODS: Cases <1 year old were identified at Enhanced Pertussis Surveillance sites between January 1, 2006 to December 31, 2013...
October 2015: Pediatrics
https://www.readbyqxmd.com/read/26278132/examining-the-role-of-different-age-groups-and-of-vaccination-during-the-2012-minnesota-pertussis-outbreak
#14
Colin J Worby, Cynthia Kenyon, Ruth Lynfield, Marc Lipsitch, Edward Goldstein
There is limited information on the roles of different age groups during pertussis outbreaks. Little is known about vaccine effectiveness against pertussis infection (both clinically apparent and subclinical), which is different from effectiveness against reportable pertussis disease, with the former influencing the impact of vaccination on pertussis transmission in the community. For the 2012 pertussis outbreak in Minnesota, we estimated odds ratios for case counts in pairs of population groups before vs. after the epidemic's peak...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26225481/atypical-presentations-of-hand-foot-and-mouth-disease-caused-by-coxsackievirus-a6-minnesota-2014
#15
Vicki W Buttery, Cynthia Kenyon, Stacey Grunewald, M Steven Oberste, W Allan Nix
In June, 2014, the Minnesota Department of Health (MDH) was notified of a suspected varicella case in a child aged 2 years. The patient had a generalized rash with relative sparing of the trunk and was hospitalized overnight for treatment of dehydration. The child's mother, who was near the end of a pregnancy, also had a generalized rash, which included the perineal area. Identifying the cause of the rash was important to determine whether administration of varicella zoster immune globulin was indicated to prevent neonatal varicella...
July 31, 2015: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/26222061/predictors-of-pertussis-polymerase-chain-reaction-positive-results-in-minnesota-2005-2009
#16
Melissa McMahon, Shalini Kulasingam, Cynthia Kenyon, Claudia Miller, Kristen Ehresmann
Predictors of polymerase chain reaction (PCR) positivity for pertussis were assessed using Minnesota active surveillance data. Report of an exposure to pertussis and testing within the optimal time frame of ≤2 weeks were significantly associated with testing PCR positive, emphasizing the importance of asking about epidemiological factors when assessing patients for pertussis, and timely PCR testing.
November 2015: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26180973/understanding-trends-in-pertussis-incidence-an-agent-based-model-approach
#17
Erinn Sanstead, Cynthia Kenyon, Seth Rowley, Eva Enns, Claudia Miller, Kristen Ehresmann, Shalini Kulasingam
OBJECTIVES: We examined the impact of undetected infections, adult immunity, and waning vaccine-acquired immunity on recent age-related trends in pertussis incidence. METHODS: We developed an agent-based model of pertussis transmission in Dakota County, Minnesota using case data from the Minnesota Department of Health. For outbreaks in 2004, 2008, and 2012, we fit our model to incidence in 3 children's age groups relative to adult incidence. We estimated parameters through model calibration...
September 2015: American Journal of Public Health
https://www.readbyqxmd.com/read/26110839/notes-from-the-field-measles-transmission-in-an-international-airport-at-a-domestic-terminal-gate-april-may-2014
#18
Emily Banerjee, Cynthia Hickman, Kathryn Engels, Cynthia Kenyon
On April 22, 2014, the Minnesota Department of Health notified CDC of a case of measles in a child aged 19 months who had documentation of receiving 1 dose of measles, mumps, and rubella vaccine at age 12 months. The child's illness was clinically compatible with measles, which was confirmed by polymerase chain reaction and immunoglobulin M serology at the Minnesota Department of Health Public Health Laboratory. The child was febrile and developed a rash on April 17 while on an international flight from India to the United States before taking a connecting flight from Chicago to Minneapolis...
June 26, 2015: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/25902704/interventions-to-slow-aging-in-humans-are-we-ready
#19
REVIEW
Valter D Longo, Adam Antebi, Andrzej Bartke, Nir Barzilai, Holly M Brown-Borg, Calogero Caruso, Tyler J Curiel, Rafael de Cabo, Claudio Franceschi, David Gems, Donald K Ingram, Thomas E Johnson, Brian K Kennedy, Cynthia Kenyon, Samuel Klein, John J Kopchick, Guenter Lepperdinger, Frank Madeo, Mario G Mirisola, James R Mitchell, Giuseppe Passarino, Karl L Rudolph, John M Sedivy, Gerald S Shadel, David A Sinclair, Stephen R Spindler, Yousin Suh, Jan Vijg, Manlio Vinciguerra, Luigi Fontana
The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?' was held in Erice, Italy, on October 8-13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans. There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age. Essential pathways have been identified, and behavioral, dietary, and pharmacologic approaches have emerged...
August 2015: Aging Cell
https://www.readbyqxmd.com/read/25301209/pertactin-negative-bordetella-pertussis-strains-evidence-for-a-possible-selective-advantage
#20
Stacey W Martin, Lucia Pawloski, Margaret Williams, Keeley Weening, Chas DeBolt, Xuan Qin, Laura Reynolds, Cynthia Kenyon, Gregory Giambrone, Kathy Kudish, Lisa Miller, David Selvage, Adria Lee, Tami H Skoff, Hajime Kamiya, Pamela K Cassiday, Maria L Tondella, Thomas A Clark
BACKGROUND: A recent increase in Bordetella pertussis without the pertactin protein, an acellular vaccine immunogen, has been reported in the United States. Determining whether pertactin-deficient (PRN(-)) B. pertussis is evading vaccine-induced immunity or altering the severity of illness is needed. METHODS: We retrospectively assessed for associations between pertactin production and both clinical presentation and vaccine history. Cases with isolates collected between May 2011 and February 2013 from 8 states were included...
January 15, 2015: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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