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Cynthia Kenyon

Vikram Narayan, Tony Ly, Ehsan Pourkarimi, Alejandro Brenes Murillo, Anton Gartner, Angus I Lamond, Cynthia Kenyon
Effective network analysis of protein data requires high-quality proteomic datasets. Here, we report a near doubling in coverage of the C. elegans adult proteome, identifying >11,000 proteins in total with ∼9,400 proteins reproducibly detected in three biological replicates. Using quantitative mass spectrometry, we identify proteins whose abundances vary with age, revealing a concerted downregulation of proteins involved in specific metabolic pathways and upregulation of cellular stress responses with advancing age...
August 2016: Cell Systems
Karen Martin, Stacy Holzbauer, Tory Whitten, Carrie Klumb, Samantha Saunders, Melissa Mcmahon, Jayne Griffith, Anna Strain, Dave Boxrud, Cynthia Kenyon, Joni Scheftel
No abstract text is available yet for this article.
December 2015: Open Forum Infectious Diseases
Antoine E Roux, Kelley Langhans, Walter Huynh, Cynthia Kenyon
Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and aging: mitochondrial fission, ROS production, protein aggregation, decreased proteotoxic-stress resistance, and at the organismal level, decline of mobility and high mortality. All signs of aging but one, the presence of protein aggregates, were reversed upon return to development induced by feeding...
June 14, 2016: Cell Metabolism
Yuehua Wei, Cynthia Kenyon
In Caenorhabditis elegans, removing germ cells slows aging and extends life. Here we show that transcription factors that extend life and confer protection to age-related protein-aggregation toxicity are activated early in adulthood in response to a burst of reactive oxygen species (ROS) and a shift in sulfur metabolism. Germline loss triggers H2S production, mitochondrial biogenesis, and a dynamic pattern of ROS in specific somatic tissues. A cytoskeletal protein, KRI-1, plays a key role in the generation of H2S and ROS...
May 17, 2016: Proceedings of the National Academy of Sciences of the United States of America
Celestin Hategekimana, Jeannie Shoveller, Lisine Tuyisenge, Cynthia Kenyon, David F Cechetto, Larry D Lynd
BACKGROUND: The Emergency, Triage, Assessment and Treatment plus Admission care (ETAT+) course, a comprehensive advanced pediatric life support course, was introduced in Rwanda in 2010 to facilitate the achievement of the fourth Millennium Development Goal. The impact of the course on improving healthcare workers (HCWs) knowledge and practical skills related to providing emergency care to severely ill newborns and children in Rwanda has not been studied. OBJECTIVE: To evaluate the impact of the ETAT+ course on HCWs knowledge and practical skills, and to identify factors associated with greater improvement in knowledge and skills...
2016: PloS One
Dalila Bensaddek, Vikram Narayan, Armel Nicolas, Alejandro Brenes Murillo, Anton Gartner, Cynthia J Kenyon, Angus I Lamond
Proteomics studies typically analyze proteins at a population level, using extracts prepared from tens of thousands to millions of cells. The resulting measurements correspond to average values across the cell population and can mask considerable variation in protein expression and function between individual cells or organisms. Here, we report the development of micro-proteomics for the analysis of Caenorhabditis elegans, a eukaryote composed of 959 somatic cells and ∼1500 germ cells, measuring the worm proteome at a single organism level to a depth of ∼3000 proteins...
February 2016: Proteomics
Tami H Skoff, Cynthia Kenyon, Noelle Cocoros, Juventila Liko, Lisa Miller, Kathy Kudish, Joan Baumbach, Shelley Zansky, Amanda Faulkner, Stacey W Martin
BACKGROUND: Pertussis is poorly controlled, with the highest rates of morbidity and mortality among infants. Although the source of infant pertussis is often unknown, when identified, mothers have historically been the most common reservoir of transmission. Despite high vaccination coverage, disease incidence has been increasing. We examined whether infant source of infection (SOI) has changed in the United States in light of the changing epidemiology. METHODS: Cases <1 year old were identified at Enhanced Pertussis Surveillance sites between January 1, 2006 to December 31, 2013...
October 2015: Pediatrics
Colin J Worby, Cynthia Kenyon, Ruth Lynfield, Marc Lipsitch, Edward Goldstein
There is limited information on the roles of different age groups during pertussis outbreaks. Little is known about vaccine effectiveness against pertussis infection (both clinically apparent and subclinical), which is different from effectiveness against reportable pertussis disease, with the former influencing the impact of vaccination on pertussis transmission in the community. For the 2012 pertussis outbreak in Minnesota, we estimated odds ratios for case counts in pairs of population groups before vs. after the epidemic's peak...
2015: Scientific Reports
Vicki W Buttery, Cynthia Kenyon, Stacey Grunewald, M Steven Oberste, W Allan Nix
In June, 2014, the Minnesota Department of Health (MDH) was notified of a suspected varicella case in a child aged 2 years. The patient had a generalized rash with relative sparing of the trunk and was hospitalized overnight for treatment of dehydration. The child's mother, who was near the end of a pregnancy, also had a generalized rash, which included the perineal area. Identifying the cause of the rash was important to determine whether administration of varicella zoster immune globulin was indicated to prevent neonatal varicella...
July 31, 2015: MMWR. Morbidity and Mortality Weekly Report
Melissa McMahon, Shalini Kulasingam, Cynthia Kenyon, Claudia Miller, Kristen Ehresmann
Predictors of polymerase chain reaction (PCR) positivity for pertussis were assessed using Minnesota active surveillance data. Report of an exposure to pertussis and testing within the optimal time frame of ≤2 weeks were significantly associated with testing PCR positive, emphasizing the importance of asking about epidemiological factors when assessing patients for pertussis, and timely PCR testing.
November 2015: Pediatric Infectious Disease Journal
Erinn Sanstead, Cynthia Kenyon, Seth Rowley, Eva Enns, Claudia Miller, Kristen Ehresmann, Shalini Kulasingam
OBJECTIVES: We examined the impact of undetected infections, adult immunity, and waning vaccine-acquired immunity on recent age-related trends in pertussis incidence. METHODS: We developed an agent-based model of pertussis transmission in Dakota County, Minnesota using case data from the Minnesota Department of Health. For outbreaks in 2004, 2008, and 2012, we fit our model to incidence in 3 children's age groups relative to adult incidence. We estimated parameters through model calibration...
September 2015: American Journal of Public Health
Emily Banerjee, Cynthia Hickman, Kathryn Engels, Cynthia Kenyon
On April 22, 2014, the Minnesota Department of Health notified CDC of a case of measles in a child aged 19 months who had documentation of receiving 1 dose of measles, mumps, and rubella vaccine at age 12 months. The child's illness was clinically compatible with measles, which was confirmed by polymerase chain reaction and immunoglobulin M serology at the Minnesota Department of Health Public Health Laboratory. The child was febrile and developed a rash on April 17 while on an international flight from India to the United States before taking a connecting flight from Chicago to Minneapolis...
June 26, 2015: MMWR. Morbidity and Mortality Weekly Report
Valter D Longo, Adam Antebi, Andrzej Bartke, Nir Barzilai, Holly M Brown-Borg, Calogero Caruso, Tyler J Curiel, Rafael de Cabo, Claudio Franceschi, David Gems, Donald K Ingram, Thomas E Johnson, Brian K Kennedy, Cynthia Kenyon, Samuel Klein, John J Kopchick, Guenter Lepperdinger, Frank Madeo, Mario G Mirisola, James R Mitchell, Giuseppe Passarino, Karl L Rudolph, John M Sedivy, Gerald S Shadel, David A Sinclair, Stephen R Spindler, Yousin Suh, Jan Vijg, Manlio Vinciguerra, Luigi Fontana
The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?' was held in Erice, Italy, on October 8-13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans. There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age. Essential pathways have been identified, and behavioral, dietary, and pharmacologic approaches have emerged...
August 2015: Aging Cell
Stacey W Martin, Lucia Pawloski, Margaret Williams, Keeley Weening, Chas DeBolt, Xuan Qin, Laura Reynolds, Cynthia Kenyon, Gregory Giambrone, Kathy Kudish, Lisa Miller, David Selvage, Adria Lee, Tami H Skoff, Hajime Kamiya, Pamela K Cassiday, Maria L Tondella, Thomas A Clark
BACKGROUND: A recent increase in Bordetella pertussis without the pertactin protein, an acellular vaccine immunogen, has been reported in the United States. Determining whether pertactin-deficient (PRN(-)) B. pertussis is evading vaccine-induced immunity or altering the severity of illness is needed. METHODS: We retrospectively assessed for associations between pertactin production and both clinical presentation and vaccine history. Cases with isolates collected between May 2011 and February 2013 from 8 states were included...
January 15, 2015: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Pamala Gahr, Aaron S DeVries, Gregory Wallace, Claudia Miller, Cynthia Kenyon, Kristin Sweet, Karen Martin, Karen White, Erica Bagstad, Carol Hooker, Gretchen Krawczynski, David Boxrud, Gongping Liu, Patricia Stinchfield, Julie LeBlanc, Cynthia Hickman, Lynn Bahta, Albert Barskey, Ruth Lynfield
Measles is readily spread to susceptible individuals, but is no longer endemic in the United States. In March 2011, measles was confirmed in a Minnesota child without travel abroad. This was the first identified case-patient of an outbreak. An investigation was initiated to determine the source, prevent transmission, and examine measles-mumps-rubella (MMR) vaccine coverage in the affected community. Investigation and response included case-patient follow-up, post-exposure prophylaxis, voluntary isolation and quarantine, and early MMR vaccine for non-immune shelter residents >6 months and <12 months of age...
July 2014: Pediatrics
Cynthia R O Jacob, Hellen M Soares, Roberta C F Nocelli, Osmar Malaspina
BACKGROUND: Studies on stingless bees are scarce, and little is known about these insects, especially regarding the effects of contamination by neurotoxic insecticides, which can cause damage to important structures of the insect brain. This study evaluated the morphological changes in the intrinsic neurons of the protocerebral mushroom bodies (Kenyon cells) of the stingless bee Scaptotrigona postica after exposure to different doses of fipronil, using light microscopy and transmission electron microscopy...
January 2015: Pest Management Science
Cynthia Kenyon, Emily Banerjee, Kristin Sweet, Claudia Miller, Kristen Ehresmann
OBJECTIVES: The Minnesota Department of Health, in collaboration with the Centers for Disease Control and Prevention, implemented the Pertussis Active Surveillance Project to better understand pertussis epidemiology. We evaluated the program's impact. METHODS: Clinics in 2 counties were offered free diagnostic testing and an educational presentation covering pertussis epidemiology. Clinics were identified as either active or intermittent, with active clinics testing 33% or more of the total number of months enrolled...
April 2014: American Journal of Public Health
Meredith E Judy, Ayumi Nakamura, Anne Huang, Harli Grant, Helen McCurdy, Kurt F Weiberth, Fuying Gao, Giovanni Coppola, Cynthia Kenyon, Aimee W Kao
Animals have many ways of protecting themselves against stress; for example, they can induce animal-wide, stress-protective pathways and they can kill damaged cells via apoptosis. We have discovered an unexpected regulatory relationship between these two types of stress responses. We find that C. elegans mutations blocking the normal course of programmed cell death and clearance confer animal-wide resistance to a specific set of environmental stressors; namely, ER, heat and osmotic stress. Remarkably, this pattern of stress resistance is induced by mutations that affect cell death in different ways, including ced-3 (cell death defective) mutations, which block programmed cell death, ced-1 and ced-2 mutations, which prevent the engulfment of dying cells, and progranulin (pgrn-1) mutations, which accelerate the clearance of apoptotic cells...
2013: PLoS Genetics
Modi Safra, Shani Ben-Hamo, Cynthia Kenyon, Sivan Henis-Korenblit
The unfolded protein response (UPR) allows cells to cope with endoplasmic reticulum (ER) stress by adjusting the capacity of the ER to the load of ER-associated tasks. The UPR is important for maintaining ER homeostasis under extreme ER stress. UPR genes are important under normal growth conditions as well, but what they are required for under these conditions is less clear. Using C. elegans, we show that the ire-1/xbp-1 arm of the UPR plays a crucial role in maintaining ER plasticity and function also in the absence of external ER stress...
September 15, 2013: Journal of Cell Science
Sara Y Tartof, Melissa Lewis, Cynthia Kenyon, Karen White, Andrew Osborn, Juventila Liko, Elizabeth Zell, Stacey Martin, Nancy E Messonnier, Thomas A Clark, Tami H Skoff
OBJECTIVE: To assess the risk of pertussis by time since vaccination in children in Minnesota and Oregon who received 5 doses of acellular pertussis vaccines (DTaP). METHODS: These cohort analyses included Minnesota and Oregon children born between 1998 and 2003 who had 5 DTaP doses recorded in state Immunization Information Systems. Immunization records and statewide pertussis surveillance data were combined. Incidence rates and risk ratios for pertussis were calculated for the 6 years after receipt of the fifth DTaP dose...
April 2013: Pediatrics
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