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David Sinclair

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https://www.readbyqxmd.com/read/29189534/pediatric-orthopaedic-surgeons-dissatisfied-in-on-call-practices-despite-improving-call-conditions-the-2015-posna-membership-survey-regarding-trauma-care
#1
Allison Lind, Kevin Latz, Mark R Sinclair, David D Williams
BACKGROUND: To examine the current trends in trauma call coverage of pediatric orthopaedic surgeons in North America and to identify predictors of surgeon on-call satisfaction. METHODS: In 2015, ∼1200 active members of the Pediatric Orthopaedic Society of North America (POSNA) were surveyed regarding emergency room on-call practices. In total, 410 members completed the survey with a response rate of 35%. Information collected included call frequency, practice setting and satisfaction with call...
November 16, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29182800/interventions-to-increase-tuberculosis-case-detection-at-primary-healthcare-or-community-level-services
#2
REVIEW
Francis A Mhimbira, Luis E Cuevas, Russell Dacombe, Abdallah Mkopi, David Sinclair
BACKGROUND: Pulmonary tuberculosis is usually diagnosed when symptomatic individuals seek care at healthcare facilities, and healthcare workers have a minimal role in promoting the health-seeking behaviour. However, some policy specialists believe the healthcare system could be more active in tuberculosis diagnosis to increase tuberculosis case detection. OBJECTIVES: To evaluate the effectiveness of different strategies to increase tuberculosis case detection through improving access (geographical, financial, educational) to tuberculosis diagnosis at primary healthcare or community-level services...
November 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29146412/skeletal-muscle-overexpression-of-nicotinamide-phosphoribosyl-transferase-in-mice-coupled-with-voluntary-exercise-augments-exercise-endurance
#3
Sheila R Costford, Bram Brouwers, Meghan E Hopf, Lauren M Sparks, Mauro Dispagna, Ana P Gomes, Heather H Cornnell, Chris Petucci, Peter Phelan, Hui Xie, Fanchao Yi, Glenn A Walter, Timothy F Osborne, David A Sinclair, Randall L Mynatt, Julio E Ayala, Stephen J Gardell, Steven R Smith
OBJECTIVE: Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD(+)), an essential co-substrate regulating a myriad of signaling pathways. We produced a mouse that overexpressed NAMPT in skeletal muscle (NamptTg) and hypothesized that NamptTg mice would have increased oxidative capacity, endurance performance, and mitochondrial gene expression, and would be rescued from metabolic abnormalities that developed with high fat diet (HFD) feeding...
November 6, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29118320/nicotinamide-mononucleotide-nmn-supplementation-ameliorates-the-impact-of-maternal-obesity-in-mice-comparison-with-exercise
#4
Golam Mezbah Uddin, Neil A Youngson, Bronte M Doyle, David A Sinclair, Margaret J Morris
Maternal overnutrition increases the risk of long-term metabolic dysfunction in offspring. Exercise improves metabolism partly by upregulating mitochondrial biogenesis or function, via increased levels of nicotinamide adenine dinucleotide (NAD(+)). We have shown that the NAD(+) precursor, nicotinamide mononucleotide (NMN) can reverse some of the negative consequences of high fat diet (HFD) consumption. To investigate whether NMN can impact developmentally-set metabolic deficits, we compared treadmill exercise and NMN injection in offspring of obese mothers...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29117315/interdisciplinary-perspectives-on-sun-safety
#5
Alan C Geller, Nina G Jablonski, Sherry L Pagoto, Jennifer L Hay, Joel Hillhouse, David B Buller, W Larry Kenney, June K Robinson, Richard B Weller, Megan A Moreno, Barbara A Gilchrest, Craig Sinclair, Jamie Arndt, Jennifer M Taber, Kasey L Morris, Laura A Dwyer, Frank M Perna, William M P Klein, Jerry Suls
Overexposure to the sun is associated with an increased risk of melanoma and nonmelanoma skin cancer, but indications of improvements in sun protection behavior are poor. Attempts to identify emerging themes in skin cancer control have largely been driven by groups of experts from a single field. In December 2016, 19 experts from various disciplines convened for Interdisciplinary Perspectives on Skin Cancer, a 2-day meeting hosted by the National Academy of Sciences. The group discussed knowledge gaps, perspectives on sun exposure, implications for skin cancer risk and other health outcomes, and new directions...
November 8, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29112879/myocardial-strain-computed-at-multiple-spatial-scales-from-tagged-magnetic-resonance-imaging-estimating-cardiac-biomarkers-for-crt-patients
#6
Matthew Sinclair, Devis Peressutti, Esther Puyol-Antón, Wenjia Bai, Simone Rivolo, Jessica Webb, Simon Claridge, Thomas Jackson, David Nordsletten, Myrianthi Hadjicharalambous, Eric Kerfoot, Christopher A Rinaldi, Daniel Rueckert, Andrew P King
Abnormal cardiac motion can indicate different forms of disease, which can manifest at different spatial scales in the myocardium. Many studies have sought to characterise particular motion abnormalities associated with specific diseases, and to utilise motion information to improve diagnoses. However, the importance of spatial scale in the analysis of cardiac deformation has not been extensively investigated. We build on recent work on the analysis of myocardial strains at different spatial scales using a cardiac motion atlas to find the optimal scales for estimating different cardiac biomarkers...
October 31, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29092180/continuous-relief-diffractive-microlenses-for-laser-beam-focusing
#7
Matthew Day, Kaushal Choonee, David Cox, Mark Thompson, Graham Marshall, Alastair G Sinclair
Microscale, continuous-profile, diffractive lenses have been fabricated and characterized. Lenses designed to operate at λ0 = 405 nm were created by focused ion beam milling of a glass substrate. The micro-structured profile was analysed by confocal microscopy and optical performance was quantified by measurements of the transmitted laser beam profile. Lenses of size 125 μm × 125 μm, containing up to 18 annuli and focusing at 400 μm, 450 μm and 500 μm have been made. Measured focused beams were in excellent agreement with the predicted performance...
October 30, 2017: Optics Express
https://www.readbyqxmd.com/read/29083100/mefloquine-for-preventing-malaria-during-travel-to-endemic-areas
#8
REVIEW
Maya Tickell-Painter, Nicola Maayan, Rachel Saunders, Cheryl Pace, David Sinclair
BACKGROUND: Mefloquine is one of four antimalarial agents commonly recommended for preventing malaria in travellers to malaria-endemic areas. Despite its high efficacy, there is controversy about its psychological side effects. OBJECTIVES: To summarize the efficacy and safety of mefloquine used as prophylaxis for malaria in travellers. SEARCH METHODS: We searched the Cochrane Infectious Diseases Group Specialized Register; the Cochrane Central Register of Controlled Trials (CENTRAL), published on the Cochrane Library; MEDLINE; Embase (OVID); TOXLINE (https://toxnet...
October 30, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29039931/profiling-cytidine-acetylation-with-specific-affinity-and-reactivity
#9
Wilson R Sinclair, Daniel Arango, Jonathan H Shrimp, Thomas T Zengeya, Justin M Thomas, David C Montgomery, Stephen D Fox, Thorkell Andresson, Shalini Oberdoerffer, Jordan L Meier
The human acetyltransferase NAT10 has recently been shown to catalyze formation of N4-acetylcytidine (ac4C), a minor nucleobase known to alter RNA structure and function. In order to better understand the role of RNA acetyltransferases in biology and disease, here we report the development and application of chemical methods to study ac4C. First, we demonstrate that ac4C can be conjugated to carrier proteins using optimized protocols. Next, we describe methods to access ac4C-containing RNAs, enabling the screening of anti-ac4C antibodies...
October 17, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29036923/environmental-impact-and-relative-invasiveness-of-free-roaming-domestic-carnivores-a-north-american-survey-of-governmental-agencies
#10
Ana Lepe, Valerie Kaplan, Alirio Arreaza, Robert Szpanderfer, David Bristol, M Scott Sinclair
A survey of the United States and Canadian governmental agencies investigated the environmental impact and relative invasiveness of free-roaming domestic non-native carnivores-dogs, cats, and ferrets. Agencies represented wildlife, fish, game, natural or environmental resources, parks and recreation, veterinary and human health, animal control, and agriculture. Respondents were asked to document the number and frequency of sightings of unconfined animals, evidence for environmental harm, and the resulting "degree of concern" in their respective jurisdictions...
October 14, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28979569/reply-to-response-to-inpatient-illness-severity-surveys-provide-essential-data-for-planning-capacity-and-managing-patient-flow-in-the-acute-hospital-setting-j-intensive-care-soc-2016-18-175-176
#11
Adam Garland, David Ashton-Cleary, Ray Sinclair
No abstract text is available yet for this article.
May 2017: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/28966371/comparison-of-outcomes-of-two-femoral-fixation-devices-in-hamstring-anterior-cruciate-ligament-reconstruction
#12
Miguel Angel Sánchez-Carrasco, Juan Francisco Abellán, Salima Qudsi-Sinclair, Guadalupe Ruiz-Merino, Francisco Javier Carrillo-Juliá, David Bo-Rueda
BACKGROUND: Tear of the anterior cruciate ligament (ACL) is a common ligamentous injury of the knee. Reconstruction of this ligament is often required to restore functional stability of the knee. Outcome of ACL reconstruction is significantly affected by how the graft is fixed to the bone. This study is to determine if there is a different clinical outcome after cortical versus cortical-cancellous suspension femoral fixation in hamstring based anterior cruciate ligament (ACL) reconstruction...
September 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28949162/polynomial-time-classical-simulation-of-quantum-ferromagnets
#13
Sergey Bravyi, David Gosset
We consider a family of quantum spin systems which includes, as special cases, the ferromagnetic XY model and ferromagnetic Ising model on any graph, with or without a transverse magnetic field. We prove that the partition function of any model in this family can be efficiently approximated to a given relative error ε using a classical randomized algorithm with runtime polynomial in ε^{-1}, system size, and inverse temperature. As a consequence, we obtain a polynomial time algorithm which approximates the free energy or ground energy to a given additive error...
September 8, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28936485/a-randomized-controlled-trial-of-lisinopril-to-decrease-lymphoid-fibrosis-in-antiretroviral-treated-hiv-infected-individuals
#14
Leslie R Cockerham, Steven A Yukl, Kara Harvill, Ma Somsouk, Sunil K Joshi, Elizabeth Sinclair, Teri Liegler, Rebecca Hoh, Sophie Lyons, Peter W Hunt, Adam Rupert, Irini Sereti, David R Morcock, Ajantha Rhodes, Claire Emson, Marc K Hellerstein, Jacob D Estes, Sharon Lewin, Steven G Deeks, Hiroyu Hatano
BACKGROUND: In HIV infection, lymphoid tissue is disrupted by fibrosis. Angiotensin converting enzyme inhibitors have anti-fibrotic properties. We completed a pilot study to assess whether the addition of lisinopril to antiretroviral therapy (ART) reverses fibrosis of gut tissue, and whether this leads to reduction of HIV RNA and DNA levels. METHODS: Thirty HIV-infected individuals on ART were randomized to lisinopril at 20mg daily or matching placebo for 24 weeks...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28888924/mesothelin-specific-immune-responses-predict-survival-of-patients-with-brain-metastasis
#15
Liu Zhenjiang, Martin Rao, Xiaohua Luo, Elisabeth Sandberg, Jiri Bartek, Esther Schoutrop, Anna von Landenberg, Qingda Meng, Davide Valentini, Thomas Poiret, Georges Sinclair, Inti-Harvey Peredo, Ernest Dodoo, Markus Maeurer
BACKGROUND: Patients with advanced malignancies, e.g. lung cancer, ovarian cancer or melanoma, frequently present with brain metastases. Clinical presentation and disease progression of cancer is in part shaped by the interaction of the immune system with malignant cells. Antigen-targeted immune responses have been implicated in the prolonged survival of patients with cancer. This includes the tumor-associated antigen (TAA) mature mesothelin, a 40kDa cell surface-bound antigen that is overexpressed in several malignancies including lung ovarian and pancreatic cancer...
September 2017: EBioMedicine
https://www.readbyqxmd.com/read/28835515/a-glucagon-like-peptide-1-receptor-agonist-reduces-intracranial-pressure-in-a-rat-model-of-hydrocephalus
#16
Hannah F Botfield, Maria S Uldall, Connar S J Westgate, James L Mitchell, Snorre M Hagen, Ana Maria Gonzalez, David J Hodson, Rigmor H Jensen, Alexandra J Sinclair
Current therapies for reducing raised intracranial pressure (ICP) under conditions such as idiopathic intracranial hypertension or hydrocephalus have limited efficacy and tolerability. Thus, there is a pressing need to identify alternative drugs. Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat diabetes and promote weight loss but have also been shown to affect fluid homeostasis in the kidney. We investigated whether exendin-4, a GLP-1R agonist, is able to modulate cerebrospinal fluid (CSF) secretion at the choroid plexus and subsequently reduce ICP in rats...
August 23, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28812625/larval-fish-dispersal-in-a-coral-reef-seascape
#17
Glenn R Almany, Serge Planes, Simon R Thorrold, Michael L Berumen, Michael Bode, Pablo Saenz-Agudelo, Mary C Bonin, Ashley J Frisch, Hugo B Harrison, Vanessa Messmer, Gerrit B Nanninga, Mark A Priest, Maya Srinivasan, Tane Sinclair-Taylor, David H Williamson, Geoffrey P Jones
Larval dispersal is a critical yet enigmatic process in the persistence and productivity of marine metapopulations. Empirical data on larval dispersal remain scarce, hindering the use of spatial management tools in efforts to sustain ocean biodiversity and fisheries. Here we document dispersal among subpopulations of clownfish (Amphiprion percula) and butterflyfish (Chaetodon vagabundus) from eight sites across a large seascape (10,000 km(2)) in Papua New Guinea across 2 years. Dispersal of clownfish was consistent between years, with mean observed dispersal distances of 15 km and 10 km in 2009 and 2011, respectively...
May 8, 2017: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/28741752/what-does-it-cost-to-feed-aged-care-residents-in-australia
#18
Cherie Hugo, Elisabeth Isenring, David Sinclair, Ekta Agarwal
AIM: Funding cuts to the aged care industry impact catering budgets and aged care staffing levels, which may in turn affect the nutritional status of aged care residents. This paper reports average food expenditure and trends in Australian residential aged care facilities (RACFs). METHODS: This is a retrospective study collecting RACFs' economic outlay data through a quarterly online survey conducted over the 2015 and 2016 financial years. RESULTS: Data were compiled from 817 RACFs, representing 64 256 residential beds and 23 million bed-days Australia-wide...
July 25, 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28728583/birth-weight-differences-between-those-offered-financial-voucher-incentives-for-verified-smoking-cessation-and-control-participants-enrolled-in-the-cessation-in-pregnancy-incentives-trial-cpit-employing-an-intuitive-approach-and-a-complier-average-causal-effects
#19
Alex McConnachie, Caroline Haig, Lesley Sinclair, Linda Bauld, David M Tappin
BACKGROUND: The Cessation in Pregnancy Incentives Trial (CPIT), which offered financial incentives for smoking cessation during pregnancy showed a clinically and statistically significant improvement in cessation. However, infant birth weight was not seen to be affected. This study re-examines birth weight using an intuitive and a complier average causal effects (CACE) method to uncover important information missed by intention-to-treat analysis. METHODS: CPIT offered financial incentives up to £400 to pregnant smokers to quit...
July 20, 2017: Trials
https://www.readbyqxmd.com/read/28705828/crispr-induced-null-alleles-show-that-frost-protects-drosophila-melanogaster-reproduction-after-cold-exposure
#20
Claire E Newman, Jantina Toxopeus, Hiroko Udaka, Soohyun Ahn, David M Martynowicz, Steffen P Graether, Brent J Sinclair, Anthony Percival-Smith
The ability to survive and reproduce after cold exposure is important in all kingdoms of life. However, even in a sophisticated genetic model system like Drosophila melanogaster, few genes have been identified as functioning in cold tolerance. The accumulation of the Frost (Fst) gene transcript increases after cold exposure, making it a good candidate for a gene that has a role in cold tolerance. However, despite extensive RNAi knockdown analysis, no role in cold tolerance has been assigned to Fst CRISPR is an effective technique for completely knocking down genes, and less likely to produce off-target effects than GAL4-UAS RNAi systems...
July 13, 2017: Journal of Experimental Biology
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