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David Sinclair

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https://www.readbyqxmd.com/read/28705828/crispr-induced-null-alleles-show-that-frost-protects-drosophila-melanogaster-reproduction-after-cold-exposure
#1
Claire E Newman, Jantina Toxopeus, Hiroko Udaka, Soohyun Ahn, David M Martynowicz, Steffen P Graether, Brent J Sinclair, Anthony Percival-Smith
The ability to survive and reproduce after cold exposure is important in all kingdoms of life. However, even in a sophisticated genetic model system like Drosophila melanogaster, few genes have been identified as functioning in cold tolerance. The accumulation of the Frost (Fst) gene transcript increases after cold exposure, making it a good candidate for a gene that has a role in cold tolerance. However, despite extensive RNAi knockdown analysis, no role in cold tolerance has been assigned to Fst CRISPR is an effective technique for completely knocking down genes, and less likely to produce off-target effects than GAL4-UAS RNAi systems...
July 13, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28667769/resistance-to-rhd-virus-in-wild-australian-rabbits-comparison-of-susceptible-and-resistant-individuals-using-a-genome-wide-approach
#2
Nina I Schwensow, Harald Detering, Stephen Pederson, Camila Mazzoni, Ron Sinclair, David Peacock, John Kovaliski, Brian Cooke, Jörns Fickel, Simone Sommer
Deciphering the genes involved in disease resistance is essential if we are to understand host-pathogen co-evolutionary processes. The Rabbit Haemorrhagic Disease Virus (RHDV) was imported into Australia in 1995 as a biocontrol agent to manage one of the most successful and devastating invasive species, the European rabbit (Oryctolagus cuniculus). During the first outbreaks of the disease, RHDV caused mortality rates of up to 97%. Recently, however, increased genetic resistance to RHDV has been reported. Here, we have aimed to identify genomic differences between rabbits that survived a natural infection with RHDV and those that died in the field by using a genome-wide Next Generation Sequencing (NGS) approach...
July 1, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28665047/external-tooth-resorption-associated-with-a-peripheral-odontogenic-fibroma-review-and-case-report
#3
Geoffrey Sinclair Heithersay, Davide Musu, Elisabetta Cotti
The purpose of the study is to document a rare case of a peripheral odontogenic fibroma with associated cervical and coronal tooth resorption in a 38-year-old female. Histopathologic features are described, the clinical management outlined and follow-up observations over 27 years detailed. The exophytic firm lesion,coral pink in appearance, located on the labial aspect of a maxillary left lateral incisor was excised, fixed in formalin and prepared for histolologic evaluation. The resorption cavity and adjacent soft tissue were treated by the topical application of trichloracetic acid prior to restoration with a glass ionomer cement and subsequent root canal treatment...
June 30, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28661375/barriers-to-and-facilitators-of-smoking-cessation-in-pregnancy-and-following-childbirth-literature-review-and-qualitative-study
#4
Linda Bauld, Hilary Graham, Lesley Sinclair, Kate Flemming, Felix Naughton, Allison Ford, Jennifer McKell, Dorothy McCaughan, Sarah Hopewell, Kathryn Angus, Douglas Eadie, David Tappin
BACKGROUND: Although many women stop smoking in pregnancy, others continue, causing harm to maternal and child health. Smoking behaviour is influenced by many factors, including the role of women's significant others (SOs) and support from health-care professionals (HPs). OBJECTIVES: To enhance understanding of the barriers to, and facilitators of, smoking cessation and the feasibility and acceptability of interventions to reach and support pregnant women to stop smoking...
June 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28653261/future-enhanced-clinical-role-of-pharmacists-in-emergency-departments-in-england-multi-site-observational-evaluation
#5
Elizabeth Hughes, David Terry, Chi Huynh, Konstantinos Petridis, Matthew Aiello, Louis Mazard, Hirminder Ubhi, Alex Terry, Keith Wilson, Anthony Sinclair
Background There are concerns about maintaining appropriate clinical staffing levels in Emergency Departments. Pharmacists may be one possible solution. Objective To determine if Emergency Department attendees could be clinically managed by pharmacists with or without advanced clinical practice training. Setting Prospective 49 site cross-sectional observational study of patients attending Emergency Departments in England. Method Pharmacist data collectors identified patient attendance at their Emergency Department, recorded anonymized details of 400 cases and categorized each into one of four possible options: cases which could be managed by a community pharmacist; could be managed by a hospital pharmacist independent prescriber; could be managed by a hospital pharmacist independent prescriber with additional clinical training; or medical team only (unsuitable for pharmacists to manage)...
June 26, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28620497/painful-ovulation-in-a-46-xx-sry-ve-adult-male-with-sox9-duplication
#6
Nandini Shankara Narayana, Anne-Maree Kean, Lisa Ewans, Thomas Ohnesorg, Katie L Ayers, Geoff Watson, Arthur Vasilaras, Andrew H Sinclair, Stephen M Twigg, David J Handelsman
46,XX disorders of sexual development (DSDs) occur rarely and result from disruptions of the genetic pathways underlying gonadal development and differentiation. We present a case of a young phenotypic male with 46,XX SRY-negative ovotesticular DSD resulting from a duplication upstream of SOX9 presenting with a painful testicular mass resulting from ovulation into an ovotestis. We present a literature review of ovulation in phenotypic men and discuss the role of SRY and SOX9 in testicular development, including the role of SOX9 upstream enhancer region duplication in female-to-male sex reversal...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28576241/rational-selection-and-use-of-antimicrobials-in-patients-with-burn-injuries
#7
REVIEW
David M Hill, Scott E Sinclair, William L Hickerson
Caring for patients with burn injuries is challenging secondary to the acute disease process, chronic comorbidities, and underrepresentation in evidence-based literature. Much current practice relies on extrapolation of guidance from different patient populations and wide variations in universal practices. Identifying infections or sepsis in this hypermetabolic population is imperfect and often leads to overprescribing of antimicrobials, suboptimal dosing, and multidrug resistance. An understanding of pharmacokinetics and pharmacodynamics may aid optimization of dosing regimens to better attain treatment targets...
July 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28555668/glucose-represses-dendritic-cell-induced-t-cell-responses
#8
Simon J Lawless, Nidhi Kedia-Mehta, Jessica F Walls, Ryan McGarrigle, Orla Convery, Linda V Sinclair, Maria N Navarro, James Murray, David K Finlay
Glucose and glycolysis are important for the proinflammatory functions of many immune cells, and depletion of glucose in pathological microenvironments is associated with defective immune responses. Here we show a contrasting function for glucose in dendritic cells (DCs), as glucose represses the proinflammatory output of LPS-stimulated DCs and inhibits DC-induced T-cell responses. A glucose-sensitive signal transduction circuit involving the mTOR complex 1 (mTORC1), HIF1α and inducible nitric oxide synthase (iNOS) coordinates DC metabolism and function to limit DC-stimulated T-cell responses...
May 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/28518221/micronutrient-supplementation-in-adults-with-hiv-infection
#9
REVIEW
Marianne E Visser, Solange Durao, David Sinclair, James H Irlam, Nandi Siegfried
BACKGROUND: Micronutrient deficiencies are common among adults living with HIV disease, particularly in low-income settings where the diet may be low in essential vitamins and minerals. Some micronutrients play critical roles in maintenance of the immune system, and routine supplementation could therefore be beneficial. This is an update of a Cochrane Review previously published in 2010. OBJECTIVES: To assess whether micronutrient supplements are effective and safe in reducing mortality and HIV-related morbidity of HIV-positive adults (excluding pregnant women)...
May 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28467485/correction-effects-of-combined-ccr5-integrase-inhibitors-based-regimen-on-mucosal-immunity-in-hiv-infected-patients-na%C3%A3-ve-to-antiretroviral-therapy-a-pilot-randomized-trial
#10
Sergio Serrano-Villar, Talia Sainz, Zhong-Min Ma, Netanya S Utay, Tae Wook-Chun, Surinder Mann, Angela D Kashuba, Basile Siewe, Anthony Albanese, Paolo Troia-Cancio, Elizabeth Sinclair, Anoma Somasunderam, Tammy Yotter, Steven G Deeks, Alan Landay, Richard B Pollard, Christopher J Miller, Santiago Moreno, David M Asmuth
[This corrects the article DOI: 10.1371/journal.ppat.1005381.].
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28336669/a-conserved-nad-binding-pocket-that-regulates-protein-protein-interactions-during-aging
#11
Jun Li, Michael S Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P Hubbard, Alvin J Y Ling, Luis A Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L Aravind, Clemens Steegborn, David A Sinclair
DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We show that NHDs are NAD(+) (oxidized form of nicotinamide adenine dinucleotide) binding domains that regulate protein-protein interactions. The binding of NAD(+) to the NHD domain of DBC1 (deleted in breast cancer 1) prevents it from inhibiting PARP1 [poly(adenosine diphosphate-ribose) polymerase], a critical DNA repair protein...
March 24, 2017: Science
https://www.readbyqxmd.com/read/28329397/resveratrol-improves-vascular-function-and-mitochondrial-number-but-not-glucose-metabolism-in-older-adults
#12
Rena M Pollack, Nir Barzilai, Valentin Anghel, Ameya S Kulkarni, Aaron Golden, Pilib O'Broin, David A Sinclair, Michael S Bonkowski, Alexander J Coleville, Danielle Powell, Sharon Kim, Ruin Moaddel, Daniel Stein, Kehao Zhang, Meredith Hawkins, Jill P Crandall
Background: Resveratrol, a plant-derived polyphenol, has been reported to improve glucose metabolism and vascular function and to extend life span in animal models, but studies in humans have been inconclusive. Methods: In a randomized, double-blind crossover study, we treated older glucose-intolerant adults (n = 30) with resveratrol (2-3 g/daily) or placebo, each for 6 weeks. A standard mixed-meal test was used to assess insulin sensitivity (Matsuda index) and secretion (C-peptide deconvolution) and vascular function by reactive hyperemia peripheral arterial tonometry...
March 16, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28291302/psychosocial-group-interventions-to-improve-psychological-well-being-in-adults-living-with-hiv
#13
REVIEW
Ingrid van der Heijden, Naeemah Abrahams, David Sinclair
BACKGROUND: Being diagnosed with human immunodeficiency virus (HIV), and labelled with a chronic, life-threatening, and often stigmatizing disease, can impact on a person's well-being. Psychosocial group interventions aim to improve life-functioning and coping as individuals adjust to the diagnosis. OBJECTIVES: To examine the effectiveness of psychosocial group interventions for improving the psychological well-being of adults living with HIV/AIDS. SEARCH METHODS: We searched the following electronic databases up to 14 March 2016: the Cochrane Central Register of Controlled Trials (CENTRAL) published in the Cochrane Library (Issue 2, 2016), PubMed (MEDLINE) (1996 to 14 March 2016), Embase (1996 to 14 March 2016), and Clinical Trials...
March 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28282522/identity-in-recovery-from-problematic-alcohol-use-a-qualitative-study-of-online-mutual-aid
#14
Sophia E Chambers, Krysia Canvin, David S Baldwin, Julia M A Sinclair
AIM: To explore how engagement with online mutual aid facilitates recovery from problematic alcohol use, focusing on identity construction processes. DESIGN: Qualitative in-depth interview study of a maximum variation sample. SETTING: Telephone interviews with UK-based users of Soberistas, an online mutual aid group for people who are trying to resolve their problematic alcohol use. PARTICIPANTS: Thirty-one members, ex-members and browsers of Soberistas (25 women, 6 men): seven currently drinking, the remainder with varying lengths of sobriety (two weeks to five years)...
February 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28196426/development-of-a-functional-observational-battery-in-the-minipig-for-regulatory-neurotoxicity-assessments
#15
Miao Zhong, Catherine Shoemake, Amber Fuller, David White, Chris Hanks, Derek Brocksmith, Jason Liu, Shayne Gad, Guy Bouchard, Alain Stricker-Krongrad
A functional observational battery (FOB) is recommended as the first-tier neurotoxicity screening in the preclinical safety pharmacology testing guidelines. Minipigs have increasingly been used in regulatory toxicology studies; however, no current FOB protocol is available for neurotoxicity testing in these species. Hence, a minipig FOB instrument was developed. A complete crossover study with Sinclair minipigs was performed to evaluate physiologic, neurologic, and behavioral effects of amphetamine, ketamine, and diazepam...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28165301/response-to-if-the-metabolic-winter-is-coming-when-will-it-be-summer-metab-syndr-relat-disord-2017-15-3
#16
Raymond J Cronise, David A Sinclair, Andrew A Bremer
No abstract text is available yet for this article.
February 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28161712/the-impact-of-mass-deworming-programmes-on-schooling-and-economic-development-an-appraisal-of-long-term-studies
#17
Sophie Jullien, David Sinclair, Paul Garner
Background: Documents from advocacy and fund-raising organizations for child mass deworming programmes in low- and middle-income countries cite unpublished economic studies claiming long-term effects on health, schooling and economic development. Methods: To summarize and appraise these studies, we searched for and included all long-term follow-up studies based on cluster-randomized trials included in a 2015 Cochrane review on deworming. We used Cochrane methods to assess risk of bias, and appraised the credibility of the main findings...
December 1, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28161711/response-development-economics-time-to-improve-research-methods
#18
David Sinclair, Sophie Jullien, Paul Garner
No abstract text is available yet for this article.
December 1, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28152731/clinical-trial-enrollment-expansion-to-the-community
#19
Jessica A Zerillo, Andrea Kruse, Natalie Faye Sinclair, Maureen Patrick, Lauren McGovern, Frances Fuller, Kelly O'Neil, Nicole Hixon, Kristie Weeks, Bruce E Johnson, Ian E Krop, Jen Savoie, Farah Daftary, Michael Constantine, Mona S Kaddis, Humberto A Rossi, Naeem Tahir, Andrew David Norden
112 Background: Oncology patients at community cancer practices generally do not access clinical trials to the same degree as patients at academic medical centers. Collaborations between research and clinical teams across academic hospitals and their affiliated community sites may help to improve this disparity. METHODS: To improve clinical trial enrollment, a multidisciplinary team of research and clinical staff from the Dana-Farber Cancer Institute main campus and a community-based satellite site implemented a program to enhance identification of breast cancer patients eligible for clinical trials...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28129573/exploring-learning-content-and-knowledge-transfer-in-baccalaureate-nursing-students-using-a-hybrid-mental-health-practice-experience
#20
Richard G Booth, Christina Ko Scerbo, Barbara Sinclair, Michele Hancock, David Reid, Eileen Denomy
BACKGROUND: Little research has been completed exploring knowledge development and transfer from and between simulated and clinical practice settings in nurse education. OBJECTIVES: This study sought to explore the content learned, and the knowledge transferred, in a hybrid mental health clinical course consisting of simulated and clinical setting experiences. DESIGN: A qualitative, interpretive descriptive study design. SETTINGS: Clinical practice consisted of six 10-hour shifts in a clinical setting combined with six two-hour simulations...
April 2017: Nurse Education Today
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