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David Sinclair

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https://www.readbyqxmd.com/read/29039931/profiling-cytidine-acetylation-with-specific-affinity-and-reactivity
#1
Wilson R Sinclair, Daniel Arango, Jonathan H Shrimp, Thomas T Zengeya, Justin M Thomas, David C Montgomery, Stephen D Fox, Thorkell Andresson, Shalini Oberdoerffer, Jordan L Meier
The human acetyltransferase NAT10 has recently been shown to catalyze formation of N4-acetylcytidine (ac4C), a minor nucleobase known to alter RNA structure and function. In order to better understand the role of RNA acetyltransferases in biology and disease, here we report the development and application of chemical methods to study ac4C. First, we demonstrate that ac4C can be conjugated to carrier proteins using optimized protocols. Next, we describe methods to access ac4C-containing RNAs, enabling the screening of anti-ac4C antibodies...
October 17, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29036923/environmental-impact-and-relative-invasiveness-of-free-roaming-domestic-carnivores-a-north-american-survey-of-governmental-agencies
#2
Ana Lepe, Valerie Kaplan, Alirio Arreaza, Robert Szpanderfer, David Bristol, M Scott Sinclair
A survey of the United States and Canadian governmental agencies investigated the environmental impact and relative invasiveness of free-roaming domestic non-native carnivores-dogs, cats, and ferrets. Agencies represented wildlife, fish, game, natural or environmental resources, parks and recreation, veterinary and human health, animal control, and agriculture. Respondents were asked to document the number and frequency of sightings of unconfined animals, evidence for environmental harm, and the resulting "degree of concern" in their respective jurisdictions...
October 14, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28979569/reply-to-response-to-inpatient-illness-severity-surveys-provide-essential-data-for-planning-capacity-and-managing-patient-flow-in-the-acute-hospital-setting-j-intensive-care-soc-2016-18-175-176
#3
https://www.readbyqxmd.com/read/28966371/comparison-of-outcomes-of-two-femoral-fixation-devices-in-hamstring-anterior-cruciate-ligament-reconstruction
#4
Miguel Angel Sánchez-Carrasco, Juan Francisco Abellán, Salima Qudsi-Sinclair, Guadalupe Ruiz-Merino, Francisco Javier Carrillo-Juliá, David Bo-Rueda
BACKGROUND: Tear of the anterior cruciate ligament (ACL) is a common ligamentous injury of the knee. Reconstruction of this ligament is often required to restore functional stability of the knee. Outcome of ACL reconstruction is significantly affected by how the graft is fixed to the bone. This study is to determine if there is a different clinical outcome after cortical versus cortical-cancellous suspension femoral fixation in hamstring based anterior cruciate ligament (ACL) reconstruction...
September 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28949162/polynomial-time-classical-simulation-of-quantum-ferromagnets
#5
Sergey Bravyi, David Gosset
We consider a family of quantum spin systems which includes, as special cases, the ferromagnetic XY model and ferromagnetic Ising model on any graph, with or without a transverse magnetic field. We prove that the partition function of any model in this family can be efficiently approximated to a given relative error ε using a classical randomized algorithm with runtime polynomial in ε^{-1}, system size, and inverse temperature. As a consequence, we obtain a polynomial time algorithm which approximates the free energy or ground energy to a given additive error...
September 8, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28936485/a-randomized-controlled-trial-of-lisinopril-to-decrease-lymphoid-fibrosis-in-antiretroviral-treated-hiv-infected-individuals
#6
Leslie R Cockerham, Steven A Yukl, Kara Harvill, Ma Somsouk, Sunil K Joshi, Elizabeth Sinclair, Teri Liegler, Rebecca Hoh, Sophie Lyons, Peter W Hunt, Adam Rupert, Irini Sereti, David R Morcock, Ajantha Rhodes, Claire Emson, Marc K Hellerstein, Jacob D Estes, Sharon Lewin, Steven G Deeks, Hiroyu Hatano
BACKGROUND: In HIV infection, lymphoid tissue is disrupted by fibrosis. Angiotensin converting enzyme inhibitors have anti-fibrotic properties. We completed a pilot study to assess whether the addition of lisinopril to antiretroviral therapy (ART) reverses fibrosis of gut tissue, and whether this leads to reduction of HIV RNA and DNA levels. METHODS: Thirty HIV-infected individuals on ART were randomized to lisinopril at 20mg daily or matching placebo for 24 weeks...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28888924/mesothelin-specific-immune-responses-predict-survival-of-patients-with-brain-metastasis
#7
Liu Zhenjiang, Martin Rao, Xiaohua Luo, Elisabeth Sandberg, Jiri Bartek, Esther Schoutrop, Anna von Landenberg, Qingda Meng, Davide Valentini, Thomas Poiret, Georges Sinclair, Inti-Harvey Peredo, Ernest Dodoo, Markus Maeurer
BACKGROUND: Patients with advanced malignancies, e.g. lung cancer, ovarian cancer or melanoma, frequently present with brain metastases. Clinical presentation and disease progression of cancer is in part shaped by the interaction of the immune system with malignant cells. Antigen-targeted immune responses have been implicated in the prolonged survival of patients with cancer. This includes the tumor-associated antigen (TAA) mature mesothelin, a 40kDa cell surface-bound antigen that is overexpressed in several malignancies including lung ovarian and pancreatic cancer...
September 2017: EBioMedicine
https://www.readbyqxmd.com/read/28835515/a-glucagon-like-peptide-1-receptor-agonist-reduces-intracranial-pressure-in-a-rat-model-of-hydrocephalus
#8
Hannah F Botfield, Maria S Uldall, Connar S J Westgate, James L Mitchell, Snorre M Hagen, Ana Maria Gonzalez, David J Hodson, Rigmor H Jensen, Alexandra J Sinclair
Current therapies for reducing raised intracranial pressure (ICP) under conditions such as idiopathic intracranial hypertension or hydrocephalus have limited efficacy and tolerability. Thus, there is a pressing need to identify alternative drugs. Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat diabetes and promote weight loss but have also been shown to affect fluid homeostasis in the kidney. We investigated whether exendin-4, a GLP-1R agonist, is able to modulate cerebrospinal fluid (CSF) secretion at the choroid plexus and subsequently reduce ICP in rats...
August 23, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28812625/larval-fish-dispersal-in-a-coral-reef-seascape
#9
Glenn R Almany, Serge Planes, Simon R Thorrold, Michael L Berumen, Michael Bode, Pablo Saenz-Agudelo, Mary C Bonin, Ashley J Frisch, Hugo B Harrison, Vanessa Messmer, Gerrit B Nanninga, Mark A Priest, Maya Srinivasan, Tane Sinclair-Taylor, David H Williamson, Geoffrey P Jones
Larval dispersal is a critical yet enigmatic process in the persistence and productivity of marine metapopulations. Empirical data on larval dispersal remain scarce, hindering the use of spatial management tools in efforts to sustain ocean biodiversity and fisheries. Here we document dispersal among subpopulations of clownfish (Amphiprion percula) and butterflyfish (Chaetodon vagabundus) from eight sites across a large seascape (10,000 km(2)) in Papua New Guinea across 2 years. Dispersal of clownfish was consistent between years, with mean observed dispersal distances of 15 km and 10 km in 2009 and 2011, respectively...
May 8, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28741752/what-does-it-cost-to-feed-aged-care-residents-in-australia
#10
Cherie Hugo, Elisabeth Isenring, David Sinclair, Ekta Agarwal
AIM: Funding cuts to the aged care industry impact catering budgets and aged care staffing levels, which may in turn affect the nutritional status of aged care residents. This paper reports average food expenditure and trends in Australian residential aged care facilities (RACFs). METHODS: This is a retrospective study collecting RACFs' economic outlay data through a quarterly online survey conducted over the 2015 and 2016 financial years. RESULTS: Data were compiled from 817 RACFs, representing 64 256 residential beds and 23 million bed-days Australia-wide...
July 25, 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28728583/birth-weight-differences-between-those-offered-financial-voucher-incentives-for-verified-smoking-cessation-and-control-participants-enrolled-in-the-cessation-in-pregnancy-incentives-trial-cpit-employing-an-intuitive-approach-and-a-complier-average-causal-effects
#11
Alex McConnachie, Caroline Haig, Lesley Sinclair, Linda Bauld, David M Tappin
BACKGROUND: The Cessation in Pregnancy Incentives Trial (CPIT), which offered financial incentives for smoking cessation during pregnancy showed a clinically and statistically significant improvement in cessation. However, infant birth weight was not seen to be affected. This study re-examines birth weight using an intuitive and a complier average causal effects (CACE) method to uncover important information missed by intention-to-treat analysis. METHODS: CPIT offered financial incentives up to £400 to pregnant smokers to quit...
July 20, 2017: Trials
https://www.readbyqxmd.com/read/28705828/crispr-induced-null-alleles-show-that-frost-protects-drosophila-melanogaster-reproduction-after-cold-exposure
#12
Claire E Newman, Jantina Toxopeus, Hiroko Udaka, Soohyun Ahn, David M Martynowicz, Steffen P Graether, Brent J Sinclair, Anthony Percival-Smith
The ability to survive and reproduce after cold exposure is important in all kingdoms of life. However, even in a sophisticated genetic model system like Drosophila melanogaster, few genes have been identified as functioning in cold tolerance. The accumulation of the Frost (Fst) gene transcript increases after cold exposure, making it a good candidate for a gene that has a role in cold tolerance. However, despite extensive RNAi knockdown analysis, no role in cold tolerance has been assigned to Fst CRISPR is an effective technique for completely knocking down genes, and less likely to produce off-target effects than GAL4-UAS RNAi systems...
July 13, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28667769/resistance-to-rhd-virus-in-wild-australian-rabbits-comparison-of-susceptible-and-resistant-individuals-using-a-genomewide-approach
#13
Nina I Schwensow, Harald Detering, Stephen Pederson, Camila Mazzoni, Ron Sinclair, David Peacock, John Kovaliski, Brian Cooke, Jörns Fickel, Simone Sommer
Deciphering the genes involved in disease resistance is essential if we are to understand host-pathogen coevolutionary processes. The rabbit haemorrhagic disease virus (RHDV) was imported into Australia in 1995 as a biocontrol agent to manage one of the most successful and devastating invasive species, the European rabbit (Oryctolagus cuniculus). During the first outbreaks of the disease, RHDV caused mortality rates of up to 97%. Recently, however, increased genetic resistance to RHDV has been reported. Here, we have aimed to identify genomic differences between rabbits that survived a natural infection with RHDV and those that died in the field using a genomewide next-generation sequencing (NGS) approach...
July 1, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28665047/external-tooth-resorption-associated-with-a-peripheral-odontogenic-fibroma-review-and-case-report
#14
Geoffrey Sinclair Heithersay, Davide Musu, Elisabetta Cotti
The purpose of the study is to document a rare case of a peripheral odontogenic fibroma with associated cervical and coronal tooth resorption in a 38-year-old female. Histopathologic features are described, the clinical management outlined and follow-up observations over 27 years detailed. The exophytic firm lesion,coral pink in appearance, located on the labial aspect of a maxillary left lateral incisor was excised, fixed in formalin and prepared for histolologic evaluation. The resorption cavity and adjacent soft tissue were treated by the topical application of trichloracetic acid prior to restoration with a glass ionomer cement and subsequent root canal treatment...
June 30, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28661375/barriers-to-and-facilitators-of-smoking-cessation-in-pregnancy-and-following-childbirth-literature-review-and-qualitative-study
#15
Linda Bauld, Hilary Graham, Lesley Sinclair, Kate Flemming, Felix Naughton, Allison Ford, Jennifer McKell, Dorothy McCaughan, Sarah Hopewell, Kathryn Angus, Douglas Eadie, David Tappin
BACKGROUND: Although many women stop smoking in pregnancy, others continue, causing harm to maternal and child health. Smoking behaviour is influenced by many factors, including the role of women's significant others (SOs) and support from health-care professionals (HPs). OBJECTIVES: To enhance understanding of the barriers to, and facilitators of, smoking cessation and the feasibility and acceptability of interventions to reach and support pregnant women to stop smoking...
June 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28653261/future-enhanced-clinical-role-of-pharmacists-in-emergency-departments-in-england-multi-site-observational-evaluation
#16
Elizabeth Hughes, David Terry, Chi Huynh, Konstantinos Petridis, Matthew Aiello, Louis Mazard, Hirminder Ubhi, Alex Terry, Keith Wilson, Anthony Sinclair
Background There are concerns about maintaining appropriate clinical staffing levels in Emergency Departments. Pharmacists may be one possible solution. Objective To determine if Emergency Department attendees could be clinically managed by pharmacists with or without advanced clinical practice training. Setting Prospective 49 site cross-sectional observational study of patients attending Emergency Departments in England. Method Pharmacist data collectors identified patient attendance at their Emergency Department, recorded anonymized details of 400 cases and categorized each into one of four possible options: cases which could be managed by a community pharmacist; could be managed by a hospital pharmacist independent prescriber; could be managed by a hospital pharmacist independent prescriber with additional clinical training; or medical team only (unsuitable for pharmacists to manage)...
August 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28620497/painful-ovulation-in-a-46-xx-sry-ve-adult-male-with-sox9-duplication
#17
Nandini Shankara Narayana, Anne-Maree Kean, Lisa Ewans, Thomas Ohnesorg, Katie L Ayers, Geoff Watson, Arthur Vasilaras, Andrew H Sinclair, Stephen M Twigg, David J Handelsman
46,XX disorders of sexual development (DSDs) occur rarely and result from disruptions of the genetic pathways underlying gonadal development and differentiation. We present a case of a young phenotypic male with 46,XX SRY-negative ovotesticular DSD resulting from a duplication upstream of SOX9 presenting with a painful testicular mass resulting from ovulation into an ovotestis. We present a literature review of ovulation in phenotypic men and discuss the role of SRY and SOX9 in testicular development, including the role of SOX9 upstream enhancer region duplication in female-to-male sex reversal...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28576241/rational-selection-and-use-of-antimicrobials-in-patients-with-burn-injuries
#18
REVIEW
David M Hill, Scott E Sinclair, William L Hickerson
Caring for patients with burn injuries is challenging secondary to the acute disease process, chronic comorbidities, and underrepresentation in evidence-based literature. Much current practice relies on extrapolation of guidance from different patient populations and wide variations in universal practices. Identifying infections or sepsis in this hypermetabolic population is imperfect and often leads to overprescribing of antimicrobials, suboptimal dosing, and multidrug resistance. An understanding of pharmacokinetics and pharmacodynamics may aid optimization of dosing regimens to better attain treatment targets...
July 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28555668/glucose-represses-dendritic-cell-induced-t-cell-responses
#19
Simon J Lawless, Nidhi Kedia-Mehta, Jessica F Walls, Ryan McGarrigle, Orla Convery, Linda V Sinclair, Maria N Navarro, James Murray, David K Finlay
Glucose and glycolysis are important for the proinflammatory functions of many immune cells, and depletion of glucose in pathological microenvironments is associated with defective immune responses. Here we show a contrasting function for glucose in dendritic cells (DCs), as glucose represses the proinflammatory output of LPS-stimulated DCs and inhibits DC-induced T-cell responses. A glucose-sensitive signal transduction circuit involving the mTOR complex 1 (mTORC1), HIF1α and inducible nitric oxide synthase (iNOS) coordinates DC metabolism and function to limit DC-stimulated T-cell responses...
May 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/28518221/micronutrient-supplementation-in-adults-with-hiv-infection
#20
REVIEW
Marianne E Visser, Solange Durao, David Sinclair, James H Irlam, Nandi Siegfried
BACKGROUND: Micronutrient deficiencies are common among adults living with HIV disease, particularly in low-income settings where the diet may be low in essential vitamins and minerals. Some micronutrients play critical roles in maintenance of the immune system, and routine supplementation could therefore be beneficial. This is an update of a Cochrane Review previously published in 2010. OBJECTIVES: To assess whether micronutrient supplements are effective and safe in reducing mortality and HIV-related morbidity of HIV-positive adults (excluding pregnant women)...
May 18, 2017: Cochrane Database of Systematic Reviews
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