Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
David Johnston, Rachael Foord, Achim Casties, Nola Viaphay, Ahmed Tohamy, Naomi Van Leeuwen, Jodie Sinclair, Daniel Talbot, Anthony Harris
OBJECTIVE: This case series explored the integration of smartwatches in a community mental health service to support severe mental illness (SMI) management and intervention. We examined whether biometric data provided by smartwatches could help to predict relapse and inform treatment decisions. METHOD: Four Australian SMI outpatients of mixed diagnoses (age range = 19-24) were selected from a prior study. Clinicians accessed patients' biometric data (activity, sleep, heart rate, and electrodermal activity) through smartwatches...
April 16, 2024: Early Intervention in Psychiatry
#2
JOURNAL ARTICLE
Eimear K Ryan, Christy Clutter, Conor De Barra, Benjamin J Jenkins, Simon O'Shaughnessy, Odhrán K Ryan, Chloe McKenna, Helen M Heneghan, Fiona Walsh, David K Finlay, Linda V Sinclair, Nicholas Jones, Daniel T Leung, Donal O'Shea, Andrew E Hogan
Mucosal-Associated Invariant T (MAIT) cells are a population of innate T cells that play a critical role in host protection against bacterial and viral pathogens. Upon activation, MAIT cells can rapidly respond via both TCR-dependent and -independent mechanisms, resulting in robust cytokine production. The metabolic and nutritional requirements for optimal MAIT cell effector responses are still emerging. Iron is an important micronutrient and is essential for cellular fitness, in particular cellular metabolism...
April 15, 2024: Journal of Immunology
#3
EDITORIAL
Desmond Leddin, Harminder Singh, David Armstrong, Kelsey Cheyne, Ciaran Galts, John Igoe, Grigorios Leontiadis, Jerry McGrath, Cara Pray, Daniel Sadowski, Neal Shahidi, Paul Sinclair, Frances Tse, Russell Yanofsky
No abstract text is available yet for this article.
April 2024: Journal of the Canadian Association of Gastroenterology
#4
REVIEW
Håkan Ashina, Hans-Christoph Diener, Cristina Tassorelli, Ann I Scher, Richard B Lipton, Patricia Pozo-Rosich, Alexandra J Sinclair, Catherine D Chong, Alan G Finkel, Messoud Ashina, Todd J Schwedt, David W Dodick, Gisela M Terwindt
BACKGROUND: Persistent headache attributed to traumatic injury to the head is divided into two subtypes, one attributed to moderate or severe traumatic injury and another attributed to mild traumatic injury (i.e., concussion). The latter is much more prevalent, in part because more than 90% of cases with traumatic brain injury are classified as mild. The pathophysiology of persistent post-traumatic headache is poorly understood and the underlying mechanisms are likely multifactorial. There is currently no approved treatment specifically for persistent post-traumatic headache, and management strategies rely on medications used for migraine or tension-type headache...
March 2024: Cephalalgia: An International Journal of Headache
#5
JOURNAL ARTICLE
Marion Sinclair-Waters, Laura S Zamorano, Zachariah Gompert, Tom Parchman, Venera Tyukmaeva, David P Hopkins, Patrik Nosil
Phenotypic variation within species can affect the ecological dynamics of populations and communities. Characterizing the genetic variation underlying such effects can help parse the roles of genetic evolution and plasticity in 'eco-evolutionary dynamics' and inform how genetic variation may shape patterns of evolution. Here we employ genome-wide association (GWA) methods in Timema cristinae stick insects and their co-occurring arthropod communities to identify genetic variation associated with community-level traits...
March 21, 2024: Journal of Evolutionary Biology
#6
JOURNAL ARTICLE
Zachary R Cohen, Dian Ding, Lijun Zhou, Saurja DasGupta, Sebastian Haas, Kimberly P Sinclair, Zoe R Todd, Roy A Black, Jack W Szostak, David C Catling
The origin of life likely occurred within environments that concentrated cellular precursors and enabled their co-assembly into cells. Soda lakes (those dominated by Na+ ions and carbonate species) can concentrate precursors of RNA and membranes, such as phosphate, cyanide, and fatty acids. Subsequent assembly of RNA and membranes into cells is a long-standing problem because RNA function requires divalent cations, e.g. Mg2+ , but Mg2+ disrupts fatty acid membranes. The low solubility of Mg-containing carbonates limits soda lakes to moderate Mg2+ concentrations (∼1 mM), so we investigated whether both RNAs and membranes function within these lakes...
March 2024: PNAS Nexus
#7
JOURNAL ARTICLE
Laurie E Davies, Gemma F Spiers, David R Sinclair, Andrew Kingston, Barbara Hanratty
BACKGROUND: A growing number of older people provide unpaid care, but contemporary research evidence on this group is limited. AIM: This study aims to describe the characteristics of older people who provide unpaid care and how these vary by socioeconomic position. METHODS: Using recent information from the English Longitudinal Study of Ageing (ELSA wave 9, 2019), we analysed cross-sectional data on 1,282 unpaid carers aged ≥50. Data on sociodemographics, health, social wellbeing, care intensity and caregiver-recipient relationships were extracted...
March 1, 2024: Age and Ageing
#8
Jae-Hyun Yang, Motoshi Hayano, Patrick T Griffin, João A Amorim, Michael S Bonkowski, John K Apostolides, Elias L Salfati, Marco Blanchette, Elizabeth M Munding, Mital Bhakta, Yap Ching Chew, Wei Guo, Xiaojing Yang, Sun Maybury-Lewis, Xiao Tian, Jaime M Ross, Giuseppe Coppotelli, Margarita V Meer, Ryan Rogers-Hammond, Daniel L Vera, Yuancheng Ryan Lu, Jeffrey W Pippin, Michael L Creswell, Zhixun Dou, Caiyue Xu, Sarah J Mitchell, Abhirup Das, Brendan L O'Connell, Sachin Thakur, Alice E Kane, Qiao Su, Yasuaki Mohri, Emi K Nishimura, Laura Schaevitz, Neha Garg, Ana-Maria Balta, Meghan A Rego, Meredith Gregory-Ksander, Tatjana C Jakobs, Lei Zhong, Hiroko Wakimoto, Jihad El Andari, Dirk Grimm, Raul Mostoslavsky, Amy J Wagers, Kazuo Tsubota, Stephen J Bonasera, Carlos M Palmeira, Jonathan G Seidman, Christine E Seidman, Norman S Wolf, Jill A Kreiling, John M Sedivy, George F Murphy, Richard E Green, Benjamin A Garcia, Shelley L Berger, Philipp Oberdoerffer, Stuart J Shankland, Vadim N Gladyshev, Bruce R Ksander, Andreas R Pfenning, Luis A Rajman, David A Sinclair
No abstract text is available yet for this article.
February 29, 2024: Cell
#9
JOURNAL ARTICLE
Jake Valeri, Charlotte Stiplosek, Sinead M O'Donovan, David Sinclair, Kathleen A Grant, Ratna Bollavarapu, Donna M Platt, Craig A Stockmeier, Barbara Gisabella, Harry Pantazopoulos
Contextual triggers are significant factors contributing to relapse in substance use disorders (SUD). Emerging evidence points to a critical role of extracellular matrix (ECM) molecules as mediators of reward memories. Chondroitin sulfate proteoglycans (CSPGs) are a subset of ECM molecules that form perineuronal nets (PNN) around inhibitory neurons. PNNs restrict synaptic connections and help maintain synapses. Rodent models suggest that modulation of PNNs may strengthen contextual reward memories in SUD. However, there is currently a lack of information regarding PNNs in the hippocampus of people with SUD as well as how comorbidity with major depressive disorder (MDD) may affect PNNs...
February 24, 2024: Translational Psychiatry
#10
JOURNAL ARTICLE
Brian Walitt, Komudi Singh, Samuel R LaMunion, Mark Hallett, Steve Jacobson, Kong Chen, Yoshimi Enose-Akahata, Richard Apps, Jennifer J Barb, Patrick Bedard, Robert J Brychta, Ashura Williams Buckley, Peter D Burbelo, Brice Calco, Brianna Cathay, Li Chen, Snigdha Chigurupati, Jinguo Chen, Foo Cheung, Lisa M K Chin, Benjamin W Coleman, Amber B Courville, Madeleine S Deming, Bart Drinkard, Li Rebekah Feng, Luigi Ferrucci, Scott A Gabel, Angelique Gavin, David S Goldstein, Shahin Hassanzadeh, Sean C Horan, Silvina G Horovitz, Kory R Johnson, Anita Jones Govan, Kristine M Knutson, Joy D Kreskow, Mark Levin, Jonathan J Lyons, Nicholas Madian, Nasir Malik, Andrew L Mammen, John A McCulloch, Patrick M McGurrin, Joshua D Milner, Ruin Moaddel, Geoffrey A Mueller, Amrita Mukherjee, Sandra Muñoz-Braceras, Gina Norato, Katherine Pak, Iago Pinal-Fernandez, Traian Popa, Lauren B Reoma, Michael N Sack, Farinaz Safavi, Leorey N Saligan, Brian A Sellers, Stephen Sinclair, Bryan Smith, Joseph Snow, Stacey Solin, Barbara J Stussman, Giorgio Trinchieri, Sara A Turner, C Stephenie Vetter, Felipe Vial, Carlotta Vizioli, Ashley Williams, Shanna B Yang, Avindra Nath
Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit PI-ME/CFS participants with matched controls to conduct deep phenotyping. Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical conditioning...
February 21, 2024: Nature Communications
#11
JOURNAL ARTICLE
Rachel E Neale, Victoria Beedle, Peter R Ebeling, Thomas Elliott, David Francis, Christian M Girgis, Louisa Gordon, Monika Janda, Graeme Jones, Robyn M Lucas, Rebecca S Mason, Philip Keith Monnington, Julia Morahan, Georgia Paxton, Craig Sinclair, Stephen Shumack, Jane Smith, Ann R Webb, David C Whiteman
OBJECTIVE: To describe the development of a new position statement regarding balancing the risks and benefits of sun exposure for Australian adults. METHODS: We conducted a Sun Exposure Summit in March 2021, with presentations from invited experts and a workshop including representation from academic, clinical, policy, and patient stakeholder organisations. The group considered advice about balancing the risks and benefits of sun exposure for Australian adults and developed a revised consensus position statement...
January 18, 2024: Australian and New Zealand Journal of Public Health
#12
JOURNAL ARTICLE
Anthony Moussa, Michaela Bennett, Dmitri Wall, Nekma Meah, Katherine York, Laita Bokhari, Leila Asfour, Huw Rees, Leonardo Spagnol Abraham, Daniel Asz-Sigall, Fitnat Buket Basmanav, Wilma Bergfeld, Regina C Betz, Bevin Bhoyrul, Ulrike Blume-Peytavi, Valerie Callender, Vijaya Chitreddy, Andrea Combalia, George Cotsarelis, Brittany Craiglow, Rachita Dhurat, Jeff Donovan, Andrei Doroshkevich, Samantha Eisman, Paul Farrant, Juan Ferrando, Aida Gadzhigoroeva, Jack Green, Ramon Grimalt, Matthew Harries, Maria Hordinsky, Alan Irvine, Victoria Jolliffe, Spartak Kaiumov, Brett King, Joyce Lee, Won-Soo Lee, Jane Li, Nino Lortkipanidze, Amy McMichael, Natasha Atanaskova Mesinkovska, Andrew Messenger, Paradi Mirmirani, Elise Olsen, Seth J Orlow, Yuliya Ovcharenko, Bianca Maria Piraccini, Rodrigo Pirmez, Adriana Rakowska, Pascal Reygagne, Lidia Rudnicka, David Saceda Corralo, Maryanne Senna, Jerry Shapiro, Pooja Sharma, Tatiana Siliuk, Michela Starace, Poonkiat Suchonwanit, Anita Takwale, Antonella Tosti, Sergio Vañó-Galván, Willem I Visser, Annika Vogt, Martin Wade, Leona Yip, Cheng Zhou, Rodney Sinclair
IMPORTANCE: Current measures of alopecia areata (AA) severity, such as the Severity of Alopecia Tool score, do not adequately capture overall disease impact. OBJECTIVE: To explore factors associated with AA severity beyond scalp hair loss, and to support the development of the Alopecia Areata Severity and Morbidity Index (ASAMI). EVIDENCE REVIEW: A total of 74 hair and scalp disorder specialists from multiple continents were invited to participate in an eDelphi project consisting of 3 survey rounds...
February 7, 2024: JAMA Dermatology
#13
JOURNAL ARTICLE
Janika Schmitt, Emma Poole, Ian Groves, David J Owen, Stephen C Graham, John Sinclair, Bernard T Kelly
The exquisite specificity of antibodies can be harnessed to effect targeted degradation of membrane proteins. Here, we demonstrate targeted protein removal utilising a protein degradation domain derived from the endogenous human protein Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9). Recombinant antibodies genetically fused to this domain drive the degradation of membrane proteins that undergo constitutive internalisation and recycling, including the transferrin receptor and the human cytomegalovirus latency-associated protein US28...
January 29, 2024: EMBO Reports
#14
JOURNAL ARTICLE
Daniel Hendrik Baron, Elizabeth Coulthard, Carslake David, Lindsey Isla Sinclair
OBJECTIVES: The effects of the COVID-19 pandemic on cognitive decline are not fully understood. Higher social activity and relationships have been associated with decreased risk of dementia. We hypothesised that risk of transition to dementia would increase after the start of the first national lockdown. METHODS: We obtained data from the Brains for Dementia (BDR) cohort, which has collected roughly annual data on 3726 older adults with and without dementia since 2008...
January 2024: International Journal of Geriatric Psychiatry
#15
JOURNAL ARTICLE
Patrick T Griffin, Alice E Kane, Alexandre Trapp, Jien Li, Matthew Arnold, Jesse R Poganik, Ryan J Conway, Maeve S McNamara, Margarita V Meer, Noah Hoffman, João A Amorim, Xiao Tian, Michael R MacArthur, Sarah J Mitchell, Amber L Mueller, Colleen Carmody, Daniel L Vera, Csaba Kerepesi, Kejun Ying, Nicole Noren Hooten, James R Mitchell, Michele K Evans, Vadim N Gladyshev, David A Sinclair
Epigenetic 'clocks' based on DNA methylation have emerged as the most robust and widely used aging biomarkers, but conventional methods for applying them are expensive and laborious. Here we develop tagmentation-based indexing for methylation sequencing (TIME-seq), a highly multiplexed and scalable method for low-cost epigenetic clocks. Using TIME-seq, we applied multi-tissue and tissue-specific epigenetic clocks in over 1,800 mouse DNA samples from eight tissue and cell types. We show that TIME-seq clocks are accurate and robust, enriched for polycomb repressive complex 2-regulated loci, and benchmark favorably against conventional methods despite being up to 100-fold less expensive...
January 10, 2024: Nature aging
#16
REVIEW
Leonard Guarente, David A Sinclair, Guido Kroemer
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatories. Multiple clinical trials have commenced to evaluate the efficacy of such agents against age-associated diseases including diabetes, cardiovascular disease, cancer, and neurodegenerative diseases. There are reasonable expectations that drugs able to decelerate or reverse aging processes will also exert broad disease-preventing or -attenuating effects...
December 22, 2023: Cell Metabolism
#17
Andrea Cipriano, Mahdi Moqri, Sun Y Maybury-Lewis, Ryan Rogers-Hammond, Tineke Anna de Jong, Alexander Parker, Sajede Rasouli, Hans Robert Schöler, David A Sinclair, Vittorio Sebastiano
No abstract text is available yet for this article.
January 4, 2024: Nature aging
#18
JOURNAL ARTICLE
Sarah A Michaud, Helena Pětrošová, Nicholas J Sinclair, Andrea L Kinnear, Angela M Jackson, Jamie C McGuire, Darryl B Hardie, Pallab Bhowmick, Milan Ganguly, Ann M Flenniken, Lauryl M J Nutter, Colin McKerlie, Derek Smith, Yassene Mohammed, David Schibli, Albert Sickmann, Christoph H Borchers
Mouse is the mammalian model of choice to study human health and disease due to its size, ease of breeding and the natural occurrence of conditions mimicking human pathology. Here we design and validate multiple reaction monitoring mass spectrometry (MRM-MS) assays for quantitation of 2118 unique proteins in 20 murine tissues and organs. We provide open access to technical aspects of these assays to enable their implementation in other laboratories, and demonstrate their suitability for proteomic profiling in mice by measuring normal protein abundances in tissues from three mouse strains: C57BL/6NCrl, NOD/SCID, and BALB/cAnNCrl...
January 2, 2024: Communications Biology
#19
REVIEW
Andrea Cipriano, Mahdi Moqri, Sun Y Maybury-Lewis, Ryan Rogers-Hammond, Tineke Anna de Jong, Alexander Parker, Sajede Rasouli, Hans Robert Schöler, David A Sinclair, Vittorio Sebastiano
Over the past decade, there has been a dramatic increase in efforts to ameliorate aging and the diseases it causes, with transient expression of nuclear reprogramming factors recently emerging as an intriguing approach. Expression of these factors, either systemically or in a tissue-specific manner, has been shown to combat age-related deterioration in mouse and human model systems at the cellular, tissue and organismal level. Here we discuss the current state of epigenetic rejuvenation strategies via partial reprogramming in both mouse and human models...
December 15, 2023: Nature aging
#20
REVIEW
Yuancheng Ryan Lu, Xiao Tian, David A Sinclair
Information storage and retrieval is essential for all life. In biology, information is primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a foundational blueprint and the epigenome, consisting of chemical modifications to DNA and histone proteins, regulates gene expression patterns and endows cells with specific identities and functions. Unlike the stable, digital nature of genetic information, epigenetic information is stored in a digital-analog format, susceptible to alterations induced by diverse environmental signals and cellular damage...
December 2023: Nature aging
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
