keyword
https://read.qxmd.com/read/38537061/cost-effectiveness-of-bevacizumab-therapy-in-the-care-of-patients-with-hereditary-hemorrhagic-telangiectasia
#1
JOURNAL ARTICLE
Daniel Wang, Satoko Ito, Christina Waldron, Ayesha Butt, Ellen Zhang, Harlan Krumholz, Hanny Al-Samkari, George Goshua
No FDA or EMA approved therapies exist for bleeding due to hereditary hemorrhagic telangiectasia (HHT), the second-most-common inherited bleeding disorder worldwide. The current standard-of-care (SOC) includes iron and red cell supplementation, alongside the necessary hemostatic procedures, none of which target underlying disease pathogenesis. Recent evidence has demonstrated that bleeding pathophysiology is amenable to systemic antiangiogenic therapy with the anti-VEGF bevacizumab. Despite its high cost, the addition of longitudinal bevacizumab to the current SOC may reduce overall healthcare resource utilization and improve patient quality-of-life...
March 27, 2024: Blood Advances
https://read.qxmd.com/read/38536450/surgical-management-of-chiari-ii-malformation-a-systematic-review-of-literature
#2
REVIEW
Rafael C C Vencio, Adriano M Lino-Filho, Renata C F Bonfim, Nayara M Pereira, Cilmária L Franco, Paulo Ronaldo J Ribeiro, Bárbara A Morais
PURPOSE: Chiari II malformation (CM-II) is a congenital malformation of the posterior fossa associated with myelomeningocele. Of the symptomatic patients, 10-33% require surgical treatment. To this date, there is not a consensus about the best surgical technique, and whether to do duroplasty. METHODS: A literature search of the PubMed database and crossed references was performed, per PRISMA guidelines. Data regarding demographic features, extent of cervicomedullary deformity, clinical presentation, surgical techniques, and clinical outcomes were extracted...
March 27, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38534350/inflammatory-skin-diseases-focus-on-the-role-of-suppressors-of-cytokine-signaling-socs-proteins
#3
REVIEW
Antonia Cianciulli, Rosa Calvello, Chiara Porro, Dario Domenico Lofrumento, Maria Antonietta Panaro
Inflammatory skin diseases include a series of disorders characterized by a strong activation of the innate and adaptive immune system in which proinflammatory cytokines play a fundamental role in supporting inflammation. Skin inflammation is a complex process influenced by various factors, including genetic and environmental factors, characterized by the dysfunction of both immune and non-immune cells. Psoriasis (PS) and atopic dermatitis (AD) are the most common chronic inflammatory conditions of the skin whose pathogeneses are very complex and multifactorial...
March 13, 2024: Cells
https://read.qxmd.com/read/38533493/suppressor-of-cytokine-signaling-3-expression-and-its-regulation-in-relation-to-inflammation-in-chronic-obstructive-pulmonary-disease
#4
JOURNAL ARTICLE
Mariaenrica Tinè, Elisabetta Balestro, Sara Carpi, Tommaso Neri, Davide Biondini, Maria Conti, Alvise Casara, Nicol Bernardinello, Elisabetta Cocconcelli, Graziella Turato, Simonetta Baraldo, Alessandro Celi, Paolo Spagnolo, Manuel G Cosio, Marina Saetta, Erica Bazzan
BACKGROUND: The family of Suppressor of Cytokine Signaling (SOCS) acts as a controller of the duration and intensity of cytokine function by negatively regulating the JAK-STAT signaling pathway. SOCS' role in inflammatory diseases in animal models is well demonstrated. However, its role in the development of human disease is still under investigation. SOCS3 plays an important role in tumor development where its downregulation has been implicated in the pathogenesis of various solid tumors such as triple-negative breast cancer...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533356/inorganic-carbon-is-overlooked-in-global-soil-carbon-research-a-bibliometric-analysis
#5
JOURNAL ARTICLE
Sajjad Raza, Annie Irshad, Andrew Margenot, Kazem Zamanian, Nan Li, Sami Ullah, Khalid Mehmood, Muhammad Ajmal Khan, Nadeem Siddique, Jianbin Zhou, Sacha J Mooney, Irina Kurganova, Xiaoning Zhao, Yakov Kuzyakov
Soils are a major player in the global carbon (C) cycle and climate change by functioning as a sink or a source of atmospheric carbon dioxide (CO2 ). The largest terrestrial C reservoir in soils comprises two main pools: organic (SOC) and inorganic C (SIC), each having distinct fates and functions but with a large disparity in global research attention. This study quantified global soil C research trends and the proportional focus on SOC and SIC pools based on a bibliometric analysis and raise the importance of SIC pools fully underrepresented in research, applications, and modeling...
March 2024: Geoderma
https://read.qxmd.com/read/38533254/a-real-world-disproportionality-analysis-of-everolimus-data-mining-of-the-public-version-of-fda-adverse-event-reporting-system
#6
JOURNAL ARTICLE
Bin Zhao, Yumei Fu, Shichao Cui, Xiangning Chen, Shu Liu, Lan Luo
Background: Everolimus is an inhibitor of the mammalian target of rapamycin and is used to treat various tumors. The presented study aimed to evaluate the Everolimus-associated adverse events (AEs) through data mining of the US Food and Drug Administration Adverse Event Reporting System (FAERS). Methods: The AE records were selected by searching the FDA Adverse Event Reporting System database from the first quarter of 2009 to the first quarter of 2022. Potential adverse event signals were mined using the disproportionality analysis, including reporting odds ratio the proportional reporting ratio the Bayesian confidence propagation neural network and the empirical Bayes geometric mean and MedDRA was used to systematically classify the results...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38533189/implementation-of-streamlining-measures-in-selecting-and-prioritising-complex-cases-for-the-cancer-multidisciplinary-team-meeting-a-mini-review-of-the-recent-developments
#7
REVIEW
Tarek Al-Hammouri, Ricardo Almeida-Magana, Tayana Soukup, Benjamin Lamb
In January 2020, NHS England and NHS Improvement, in the United Kingdom, issued a permissive framework for streamlining cancer multidisciplinary (MDT) meetings. Streamlining is defined as a process whereby complex cases are prioritized for full discussion by an MDT in an MDT meeting (MDM), while the management of straightforward cases is expedited using Standards of Care (SoC). SoC are points in the pathway of patient management where there are recognized guidelines and clear clinical consensus on the options for management and should be regionally agreed and uniformly applied by regional Cancer Alliances...
2024: Front Health Serv
https://read.qxmd.com/read/38531461/influence-of-ozone-pollution-on-the-mixing-state-and-formation-of-oxygenated-organics-containing-single-particles
#8
JOURNAL ARTICLE
Sulin Liu, Suxia Yang, Duanying Chen, Liyuan Mao, Xiaoya Cheng, Zhen Zhou, Chenglei Pei, Mei Li, Chunlei Cheng
The formation and aging processes of oxygenated organic molecules (OOMs) are important for understanding the formation mechanisms of secondary organic aerosols (SOAs) in the field. In this study, we investigated the mixing states of OOM particles by identifying several oxygenated species along with the distributions of secondary organic carbon (SOC) during both clean and ozone (O3 )-polluted periods in July and September of 2022 in Guangzhou, China. OOM-containing particles accounted for 57 % and 49 % of the total detected single particles in July and September, respectively...
March 24, 2024: Science of the Total Environment
https://read.qxmd.com/read/38529261/dual-specificity-tyrosine-phosphorylation-regulated-kinase-3-expression-and-its-correlation-with-prognosis-and-growth-of-serous-ovarian-cancer-correlation-of-dyrk3-with-ovarian-cancer-survival
#9
JOURNAL ARTICLE
Jia Sun, Yingzi Zhang, Aijie Li, Hao Yu
BACKGROUND: Epithelial ovarian cancer, primarily serous ovarian cancer (SOC), stands as a predominant cause of cancer-related mortality among women globally, emphasizing the urgent need for comprehensive research into its molecular underpinnings. Within this context, the dual-specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3) has emerged as a potential key player with implications for prognosis and tumor progression. METHODS: This study conducted a meticulous retrospective analysis of 254 SOC cases from our medical center to unravel the prognostic significance of DYRK3...
2024: International Journal of Genomics
https://read.qxmd.com/read/38527397/soc-bioavailability-significantly-correlated-with-the-microbial-activity-mediated-by-size-fractionation-and-soil-morphology-in-agricultural-ecosystems
#10
JOURNAL ARTICLE
Shujie Xiao, Jie Gao, Qiuying Wang, Zixuan Huang, Guoqiang Zhuang
Despite the fact that physical and chemical processes have been widely proposed to explicate the stabilization mechanisms of soil organic carbon (SOC), thebioavailability of SOC linked to soil physical structure, microbial community structure, and functional genes remains poorly understood. This study aims to investigate the SOC division based on bioavailability differences formed by physical isolation, and to clarify the relationships of SOC bioavailability with soil elements, pore characteristics, and microbial activity...
March 20, 2024: Environment International
https://read.qxmd.com/read/38526510/-ab-initio-calculations-of-the-spectra-and-lifetimes-of-the-lead-dimer
#11
JOURNAL ARTICLE
Lidan Xiao, Boris F Minaev, Hans Ågren, Bing Yan
Owing to the key role of the lead dimer (Pb2 ) as a heavy element benchmark for the Group IV-A dimers the assignment of its spectroscopic properties and chemical bonding is an important undertaking. To meet this demand, the present work provides comprehensive and detailed information on electronic structure and properties comprising a wide set of Pb2 states. Calculations are performed by a high-level ab initio approach. Firstly, the potential energy curves (PECs) of 19 Λ-S states as well as those of 24 ungerade Ω states are calculated by utilizing the multi-reference configuration interaction plus Davidson correction (MRCI + Q) method taking into account core-valence correlation (CV) and spin-orbit coupling (SOC) effect, where Ω is a quantum number of the total (Λ + S) angular momentum projection...
March 25, 2024: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/38524772/cost-effectiveness-analysis-for-commonly-used-human-cell-and-tissue-products-in-the-management-of-diabetic-foot-ulcers
#12
JOURNAL ARTICLE
Leo M Nherera, Jaideep Banerjee
BACKGROUND AND AIMS: This study considers the cost-effectiveness of commonly used cellular, acellular, and matrix‑like products (CAMPs) of human origin also known as human cell and tissue products (HCT/Ps) in the management of diabetic foot ulcers. METHODS: We developed a 1-year economic model assessing six CAMPs [cryopreserved placental membrane with viable cells (vCPM), bioengineered bilayered living cellular construct (BLCC), human fibroblast dermal substitute (hFDS), dehydrated human amnion chorion membrane (dHACM), hypothermically stored amniotic membrane (HSAM) and human amnion membrane allograft (HAMA) which had randomized controlled trial evidence compared with standard of care (SoC)...
March 2024: Health Science Reports
https://read.qxmd.com/read/38523099/effects-of-fresh-salt-water-interaction-on-spatial-variations-of-soil-organic-carbon-in-reed-wetland-of-yellow-river-estuary
#13
JOURNAL ARTICLE
Miao Yu, Xue-Lian Guo, Yun-Zhao Li, Kun Zhang, Zhao-Hong DU
Estuarine wetlands exhibit significant interaction between fresh and salt water, with long-term carbon sequestration capability. We set up 60 sampling sites in the reed wetlands of the fresh-salt water interaction zone of the Yellow River Estuary, covering four different zones of the weak-intensity fresh-salt water interaction zone (WIZ), medium-intensity fresh-salt water interaction zone (MIZ), high-intensity interaction fresh-salt water zone (HIZ) and strong-intensity fresh-salt water interaction zone (SIZ)...
February 2024: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://read.qxmd.com/read/38522280/afforestation-enhances-glomalin-related-soil-protein-content-but-decreases-its-contribution-to-soil-organic-carbon-in-a-subtropical-karst-area
#14
JOURNAL ARTICLE
Rui Gu, Kongcao Xiao, Zihong Zhu, Xunyang He, Dejun Li
Afforestation on degraded croplands has been proposed as an effective measure to promote ecosystem functions including soil organic carbon (SOC) sequestration. Glomalin-related soil protein (GRSP) plays a crucial role in promoting the accumulation and stability of SOC. Nevertheless, mechanisms underlying the effects of afforestation on GRSP accumulation have not been well elucidated. In the present study, 14 pairs of maize fields and plantation forests were selected using a paired-site approach in a karst region of southwest China...
March 23, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38519988/tocilizumab-in-chronic-active-antibody-mediated-rejection-rationale-and-protocol-of-an-in-progress-randomized-controlled-open-label-multi-center-trial-intercept-study
#15
JOURNAL ARTICLE
Lillian Streichart, Marie Felldin, Jana Ekberg, Lars Mjörnstedt, Per Lindnér, Annette Lennerling, Verena Bröcker, Johan Mölne, Jan Holgersson, Kristien Daenen, Lars Wennberg, Tomas Lorant, Seema Baid-Agrawal
BACKGROUND: Chronic active antibody-mediated rejection (caAMR) in kidney transplants is associated with irreversible tissue damage and a leading cause of graft loss in the long-term. However, the treatment for caAMR remains a challenge to date. Recently, tocilizumab, a recombinant humanized monoclonal antibody directed against the human interleukin-6 (IL-6) receptor, has shown promise in the treatment of caAMR. However, it has not been systematically investigated so far underscoring the need for randomized controlled studies in this area...
March 22, 2024: Trials
https://read.qxmd.com/read/38517460/prospective-investigation-of-optical-genome-mapping-for-prenatal-genetic-diagnosis
#16
JOURNAL ARTICLE
Min Xie, Zhao-Jing Zheng, Ying Zhou, Yu-Xin Zhang, Qiong Li, Li-Yun Tian, Juan Cao, Yan-Ting Xu, Jie Ren, Qi Yu, Shan-Shan Wu, Shu Fang, Dan-Yan Zhuang, Juan Geng, Chang-Shui Chen, Hai-Bo Li
BACKGROUND: Optical genome mapping (OGM) is a novel assay for detecting structural variants (SVs) and has been retrospectively evaluated for its performance. However, its prospective evaluation in prenatal diagnosis remains unreported. This study aimed to prospectively assess the technical concordance of OGM with standard of care (SOC) testing in prenatal diagnosis. METHODS: A prospective cohort of 204 pregnant women was enrolled in this study. Amniotic fluid samples from these women were subjected to OGM and SOC testing, which included chromosomal microarray analysis (CMA) and karyotyping (KT) in parallel...
March 22, 2024: Clinical Chemistry
https://read.qxmd.com/read/38517329/evaluating-appropriateness-of-18f-fluciclovine-pet-ct-relative-to-standard-of-care-imaging-guidelines-and-the-impact-of-adt-on-positivity-a-prospective-study-in-62-veterans-administration-patients-at-a-single-institution
#17
JOURNAL ARTICLE
Aileen Green, Peter Temsah, Leonard Goldfarb, Kristen Sanfolippo, Eric Knoche, Razi Muzaffar, Medhat M Osman
BACKGROUND: According to the National Comprehensive Cancer Network Guidelines, 18F-fluciclovine PET/CT is considered appropriate after negative standard of care (SOC) imaging. OBJECTIVE: To prospectively compare 18F-fluciclovine to SOC imaging, investigate whether it should be done when SOC imaging is (+), and evaluate its detection rate in patients receiving androgen deprivation therapy. METHODS: We recruited 57 prostate cancer patients with biochemical recurrence with 18F-fluciclovine PET/CT and SOC imaging within 30 days...
March 22, 2024: Nuclear Medicine Communications
https://read.qxmd.com/read/38516344/a-global-synthesis-and-conceptualization-of-the-magnitude-and-duration-of-soil-carbon-losses-in-response-to-forest-disturbances
#18
JOURNAL ARTICLE
Mathias Mayer, Andri Baltensweiler, Jason James, Andreas Rigling, Frank Hagedorn
AIM: Forest disturbances are increasing around the globe due to changes in climate and management, deteriorating forests' carbon sink strength. Estimates of global forest carbon budgets account for losses of plant biomass but often neglect the effects of disturbances on soil organic carbon (SOC). Here, we aimed to quantify and conceptualize SOC losses in response to different disturbance agents on a global scale. LOCATION: Global. TIME PERIOD: 1983-2022...
January 2024: Global Ecology and Biogeography: a Journal of Macroecology
https://read.qxmd.com/read/38516030/comorbidity-burden-in-psoriasis-patients-with-skin-of-color
#19
JOURNAL ARTICLE
Hannah Peterson, Margaret Y Huang, Kathryn Lee, Paige Kingston, Danielle Yee, Edwin Korouri, Rosario Agüero, April W Armstrong
BACKGROUND: Psoriasis is a chronic disease with increased risk of numerous comorbidities. Known differences exist regarding treatment outcomes for psoriasis patients with skin of color (SOC). However, factors contributing to these differences are relatively unknown. OBJECTIVES: This study aims to compare the comorbidity burden in SOC psoriasis patients vs. White patients, as measured by the Charlson Comorbidity Index (CCI) score. METHODS: We utilized the National Ambulatory Medical Care Survey (NAMCS) to identify visits for adult psoriasis patients occurring in the years 2002-2016 and 2018...
January 2024: Journal of Psoriasis and Psoriatic Arthritis
https://read.qxmd.com/read/38514862/gpr41-deficiency-aggravates-type-1-diabetes-in-streptozotocin-treated-mice-by-promoting-dendritic-cell-maturation
#20
JOURNAL ARTICLE
Jia-Hong Li, Ming Zhang, Zhao-di Zhang, Xiao-Hua Pan, Li-Long Pan, Jia Sun
Disturbances in intestinal immune homeostasis predispose susceptible individuals to type 1 diabetes (T1D). G-protein-coupled receptor 41 (GPR41) is a receptor for short-chain fatty acids (SCFAs) mainly produced by gut microbiota, which plays key roles in maintaining intestinal homeostasis. In this study, we investigated the role of GPR41 in the progression of T1D. In non-obese diabetic (NOD) mice, we found that aberrant reduction of GPR41 expression in the pancreas and colons was associated with the development of T1D...
March 21, 2024: Acta Pharmacologica Sinica
keyword
keyword
107883
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.