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https://www.readbyqxmd.com/read/28636988/role-of-the-jak2-stat3-signaling-pathway-in-the-pathogenesis-of-type-2-diabetes-mellitus-with-macrovascular-complications
#1
Mengxue Yang, Mei Tian, Xuan Zhang, Jie Xu, Bo Yang, Jie Yu, Fengping Li, Ya Li, Sicheng Li, Xianwen Li
This study investigated the role of the JAK2/STAT3/SOCS pathway in type 2 diabetes mellitus (T2DM) and macrovascular complications (DV) (T2DM+DV) conditions. Human umbilical vein endothelial cells (HUVECs) were co-cultured with human monocytes (THP-1) and exposed to peripheral blood sera from 30 T2DM patients, 30 patients with T2DM+DV and 30 healthy controls; the groups were divided into the control, T2DM, DV, T2DM+AG490 and DV+AG490 groups. Chemotaxis of treated HUVECs toward THP-1 cells was assessed using Transwell migration...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28636484/bezlotoxumab-anti-toxin-b-monoclonal-antibody-to-prevent-recurrence-of-clostridium-difficile-infection
#2
Javier A Villafuerte Gálvez, Ciarán P Kelly
Clostridium difficile infection (CDI) is the most common nosocomial infection in the U.S. 25% of CDI patients go on to develop recurrent CDI (rCDI) following current standard of care (SOC) therapy, leading to morbidity, mortality and economic loss. The first passive immunotherapy drug targeting C.difficile toxin B (bezlotoxumab) has been approved recently by the FDA and EMA for prevention of rCDI. Areas covered: A body of key studies was selected and reviewed by the authors. The unmet needs in CDI care were ascertained with emphasis in rCDI, including the epidemiology, pathophysiology and current management...
June 21, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28634387/quasiparticle-and-optical-properties-of-strained-stanene-and-stanane
#3
Pengfei Lu, Liyuan Wu, Chuanghua Yang, Dan Liang, Ruge Quhe, Pengfei Guan, Shumin Wang
Quasiparticle band structures and optical properties of two dimensional stanene and stanane (fully hydrogenated stanene) are studied by the GW and GW plus Bethe-Salpeter equation (GW-BSE) approaches, with inclusion of the spin-orbit coupling (SOC). The SOC effect is significant for the electronic and optical properties in both stanene and stanane, compared with their group IV-enes and IV-anes counterparts. Stanene is a semiconductor with a quasiparticle band gap of 0.10 eV. Stanane has a sizable band gap of 1...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634059/a-pumpkin-polysaccharide-induces-apoptosis-by-inhibiting-the-jak2-stat3-pathway-in-human-hepatoma-hepg2-cells
#4
Weixi Shen, Chunhong Chen, Yuanyuan Guan, Xiaowei Song, Yinghua Jin, Jingfang Wang, Yu Hu, Tao Xin, Qiuying Jiang, Li Zhong
The purpose of this study is to investigate the effect of a purified polysaccharide (PPPF) from pumpkin fruit on the Janus activated kinase (JAK)/signal transducer and activator of transcription (STAT) signaling during apoptotic process. The results showed that PPPF or STAT3 siRNA inhibits the cell growth of HepG2 cells via induction of apoptosis. Moreover, PPPF is able to suppress both constitutive and IL-6-induced phosphorylation of STAT3 (on Tyr705) and subsequent nuclear translocation in cancer cells. Such inhibition is found to be achieved through down-regulation of constitutive phosphorylation of JAK2, but not JAk1, c-Src, ERK1/2, and Akt, which means STAT3 tyrosine phosphorylation in HepG2 cells following PPPF treatment is associated with a reduction in JAK2 activity...
June 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28634030/effects-of-membrane-curvature-and-ph-on-proton-pumping-activity-of-single-cytochrome-bo3-enzymes
#5
Mengqiu Li, Sanobar Khan, Honglin Rong, Roman Tuma, Nikos S Hatzakis, Lars J C Jeuken
The molecular mechanism of proton pumping by heme-copper oxidases (HCO) has intrigued the scientific community since it was first proposed. We have recently reported a novel technology that enables the continuous characterisation of proton transport activity of a HCO and ubiquinol oxidase from Escherichia coli, cytochrome bo3, for hundreds of seconds on the single enzyme level (Li et al. J Am Chem Soc 137 (2015) 16055-16063). Here, we have extended these studies by additional experiments and analyses of the proton transfer rate as a function of proteoliposome size and pH at the N- and P-side of single HCOs...
June 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28633959/characterization-of-the-superior-olivary-complex-of-canis-lupus-domesticus
#6
Tatiana Fech, Lilian Calderón-Garcidueñas, Randy J Kulesza
The superior olivary complex (SOC) is a collection of brainstem auditory nuclei which play essential roles in the localization of sound sources, temporal coding of vocalizations and descending modulation of the cochlea. Notwithstanding, the SOC nuclei vary considerably between species in accordance with the auditory needs of the animal. The canine SOC was subjected to anatomical and physiological examination nearly 50 years ago and was then virtually forgotten. Herein, we aimed to characterize the nuclei of the canine SOC using quantitative morphometrics, estimation of neuronal number, histochemistry for perineuronal nets and immunofluorescence for the calcium binding proteins calbindin and calretinin...
June 15, 2017: Hearing Research
https://www.readbyqxmd.com/read/28633606/exact-bayesian-p-values-for-a-test-of-independence-in-a-2%C3%A2-%C3%A3-%C3%A2-2-contingency-table-with-missing-data
#7
Yan Lin, Stuart R Lipsitz, Debajyoti Sinha, Garrett Fitzmaurice, Steven Lipshultz
Altham (Altham PME. Exact Bayesian analysis of a 2 × 2 contingency table, and Fisher's "exact" significance test. J R Stat Soc B 1969; 31: 261-269) showed that a one-sided p-value from Fisher's exact test of independence in a 2 × 2 contingency table is equal to the posterior probability of negative association in the 2 × 2 contingency table under a Bayesian analysis using an improper prior. We derive an extension of Fisher's exact test p-value in the presence of missing data, assuming the missing data mechanism is ignorable (i...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28632802/diversity-in-dermatology-a-society-devoted-to-skin-of-color
#8
Jacob Subash, Rechelle Tull, Amy McMichael
The US Census Bureau predicts that more than half of the country's population will identify as a race other than non-Hispanic white by the year 2044. Racial disparities also exist in the physician population where black individuals and Latinos are underrepresented. The Skin of Color Society (SOCS) was established to address the need for parity among dermatology patients with skin of color. The society provides educational support on dermatologic health related to skin of color and functions through committees that represent the multifaceted aspects of the organization...
May 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28632097/the-moderating-effect-of-neighborhood-sense-of-community-on-predictors-of-substance-use-among-hispanic-urban-youth
#9
David T Lardier, Marisa MacDonnell, Veronica R Barrios, Pauline Garcia-Reid, Robert J Reid
Hispanic adolescents represent a disproportionate number of youth living in urban communities. These youth confront significant social problems that increase their likelihood for substance use. However, youth that have a greater neighborhood sense of community are postulated, through empowerment theory, to be less influenced by negative environmental experiences and less inclined to engage in drug and alcohol use. We examine the moderating effect neighborhood SOC has on predictors of substance use among Hispanic (N = 538) urban youth in low- (n = 246) and high-conflict homes (n = 292)...
February 26, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/28631497/cost-effectiveness-of-blinatumomab-versus-salvage-chemotherapy-in-relapsed-or-refractory-philadelphia-chromosome-negative-b-precursor-acute-lymphoblastic-leukemia-from-a-us-payer-perspective
#10
Thomas E Delea, Jordan Amdahl, Diana Boyko, May Hagiwara, Zachary F Zimmerman, Janet L Franklin, Ze Cong, Guy Hechmati, Anthony Stein
Objective To evaluate the cost-effectiveness of blinatumomab (Blincyto) versus standard of care (SOC) chemotherapy in adults with relapsed or refractory (R/R) Philadelphia-chromosome-negative (Ph-) B-precursor acute lymphoblastic leukemia (ALL) based on the results of the phase 3 TOWER study from a US healthcare payer perspective. Methods The Blincyto Global Economic Model (B-GEM), a partitioned survival model, was used to estimate the incremental cost-effectiveness ratio (ICER) of blinatumomab versus SOC. Response rates, event free survival (EFS), overall survival (OS), numbers of cycles of blinatumomab and SOC, and transplant rates were estimated from TOWER...
June 20, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28631483/amyloid-beta-peptide-folding-in-reverse-micelles
#11
Gozde Eskici, Paul H Axelsen
Previously published experimental studies have suggested that when the 40-residue amyloid beta peptide is encapsulated in a reverse micelle, it folds into a structure that may nucleate amyloid fibril formation (Yeung and Axelsen, J. Am. Chem. Soc. 134:6061, 2012). The factors that induce the formation of this structure have now been identified in a multi-microsecond simulation of the same reverse micelle system that was studied experimentally. Key features of the polypeptide-micelle interaction include the anchoring of a hydrophobic residue cluster into the reverse micelle surface, the formation of a beta turn at the anchor point that brings N- and C-terminal segments of the polypeptide into proximity, high ionic strength that promotes intramolecular hydrogen bond formation, and deformation of the reverse micelle surface to facilitate interactions with the surface along the entire length of the polypeptide...
June 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28630633/djc-suppresses-advanced-glycation-end-products-induced-jak-stat-signaling-and-ros-in-mesangial-cells
#12
Min Sun, Yan Li, Wenjie Bu, Jindong Zhao, Jianliang Zhu, Lingling Gu, Pingping Zhang, Zhaohui Fang
The antidiabetic properties and anti-inflammatory effects of Danzhi Jiangtang Capsules (DJC) have been demonstrated in clinical and laboratory experiments. In this study, we explored whether DJC can ameliorate advanced glycation end products- (AGEs-) mediated cell injury and the precise mechanisms of DJC in treating diabetic nephropathy (DN). Western blot analysis was employed to assess the expressions of iNOS, COX2, and SOCS and the phosphorylation of JAK2, STAT1, and STAT3 in glomerular mesangial cells (GMCs) after treatment with DJC...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28627899/parenting-stress-as-a-mediator-of-trauma-exposure-and-mental-health-outcomes-in-young-children
#13
Melissa L Whitson, Joy S Kaufman
Exposure to potentially traumatic events (PTEs) significantly impacts outcomes for children in behavioral health systems of care (SOCs). The present study built on previous research that found parenting stress influences outcomes for children exposed to PTEs. The sample included 184 young children and their families who were enrolled in an early childhood SOC. Path analyses demonstrated that parenting stress mediated the relationship between the number of PTEs a child experienced and caregiver-reported internalizing/externalizing problem behaviors at baseline...
June 19, 2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/28626997/discovery-of-a-calcium-dependent-enzymatic-cascade-for-the-selective-assembly-of-hapalindole-type-alkaloids-on-the-biosynthetic-origin-of-hapalindole-u
#14
Qin Zhu, Xinyu Liu
Hapalindole U (4) is a validated biosynthetic precursor to ambiguine alkaloids (Angew. Chem. Int. Ed. 2016, 55, 5780), of which biogenetic origin remains unknown. The recent discovery of AmbU4 (or FimC1) protein encoded in the ambiguine biosynthetic pathway (J. Am. Chem. Soc., 2015, 137, 15366), an isomerocyclase that can rearrange and cyclize geranylated indolenine (2) to a previously unknown 12-epi-hapalindole U (3), raised the question whether 3 is a direct precursor to 4 or an artifact arising from the limited in vitro experiments...
June 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28625263/-bacterial-endotoxin-induced-endothelial-cell-injury-and-calcium-overload-associated-with-toll-like-receptor-and-calcium-signal
#15
Jianguo Xiao, Qing Song, Tanshi Li, Rongju Sun
OBJECTIVE: To explore the effect of toll-like receptor 4 (TLR4), myeloid differentiation protein-2 (MD2), and stromal interaction molecular 1 (STIM1) for regulating human vascular endothelial calcium overload injury and inflammatory reaction induced by bacterial endotoxin (LPS). METHODS: Human umbilical vein endothelial cells (HUVECs) were cultured in Dulbecco's modification of Eagle's medium (DMEM). (1) The levels of TLR4, MD2 and nuclear factor-κB (NF-κB) were detected by reverse transcriotion-polymerase chain reaction (RT-PCR) before and 0...
February 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28623819/the-texture-structure-and-nutrient-availability-of-artificial-soil-on-cut-slopes-restored-with-osss-influence-of-restoration-time
#16
Zhiyu Huang, Jiao Chen, Xiaoyan Ai, Ruirui Li, Yingwei Ai, Wei Li
Outside soil spray seeding (OSSS) is widely used to restore cut slopes in southwest of China, and artificial soil is often sprayed onto cut slopes to establish a soil layer for revegetation. The stability of artificial soil layer and its supply of water and nutrients for plants is crucial for successful restoration. To evaluate the long-term effectiveness of OSSS, the texture, structure and nutrient availability of artificial soil were studied, various soil samples were obtained from three cut slopes with different restoration time (restored with OSSS in 1996, 2003 and 2007 respectively) and one natural developed slope (NS)...
June 14, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28621776/tuning-pt-and-cu-sites-population-inside-functionalized-uio-67-mof-by-controlling-activation-conditions
#17
L Braglia, E Borfecchia, K A Lomachenko, A L Bugaev, A A Guda, A V Soldatov, B T L Bleken, S Øien-Ødegaard, U Olsbye, K P Lillerud, S Bordiga, G Agostini, M Manzoli, C Lamberti
The exceptional thermal and chemical stability of the UiO-66, -67 and -68 classes of isostructural MOFs [J. Am. Chem. Soc., 2008, 130, 13850] makes them ideal materials for functionalization purposes aimed at introducing active centres for potential application in heterogeneous catalysis. We previously demonstrated that a small fraction (up to 10%) of the linkers in the UiO-67 MOF can be replaced by bipyridine-dicarboxylate (bpydc) moieties exhibiting metal-chelating ability and enabling the grafting of Pt(ii) and Pt(iv) ions in the MOF framework [Chem...
June 16, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28620848/cost-effectiveness-of-pembrolizumab-vs-standard-of-care-chemotherapy-as-first-line-treatment-for-metastatic-nsclc-that-expresses-high-levels-of-pd-l1-in-the-united-states
#18
Min Huang, Yanyan Lou, James Pellissier, Thomas Burke, Frank Xiaoqing Liu, Ruifeng Xu, Vamsidhar Velcheti
OBJECTIVES: Our objectives were to evaluate the cost effectiveness of pembrolizumab compared with standard-of-care (SoC) platinum-based chemotherapy as first-line treatment in patients with metastatic non-small-cell lung cancer (NSCLC) that expresses high levels of programmed death ligand-1 (PD-L1) [tumour proportion score (TPS) ≥50%], from a US third-party public healthcare payer perspective. METHODS: We conducted a partitioned-survival model with a cycle length of 1 week and a base-case time horizon of 20 years...
June 15, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28619826/a-toolkit-for-gfp-mediated-tissue-specific-protein-degradation-in-c-elegans
#19
Shaohe Wang, Ngang Heok Tang, Pablo Lara-Gonzalez, Zhiling Zhao, Dhanya K Cheerambathur, Bram Prevo, Andrew D Chisholm, Arshad Desai, Karen Oegema
Proteins essential for embryo production, cell division, and early embryonic events are frequently re-utilized later in embryogenesis, during organismal development, or in the adult. Examining protein function across these different biological contexts requires tissue-specific perturbation. Here, we describe a method that utilizes expression of a fusion between a GFP-targeting nanobody and a SOCS-box containing ubiquitin ligase adaptor to target GFP tagged proteins for degradation. When combined with endogenous locus GFP tagging by CRISPR-Cas9 or rescue of a null mutant with a GFP fusion, this approach enables routine and efficient tissue-specific protein ablation...
June 15, 2017: Development
https://www.readbyqxmd.com/read/28618529/completeness-of-inertial-modes-of-an-incompressible-inviscid-fluid-in-a-corotating-ellipsoid
#20
George Backus, Michel Rieutord
Inertial modes are the eigenmodes of contained rotating fluids restored by the Coriolis force. When the fluid is incompressible, inviscid, and contained in a rigid container, these modes satisfy Poincaré's equation that has the peculiarity of being hyperbolic with boundary conditions. Inertial modes are, therefore, solutions of an ill-posed boundary-value problem. In this paper, we investigate the mathematical side of this problem. We first show that the Poincaré problem can be formulated in the Hilbert space of square-integrable functions, with no hypothesis on the continuity or the differentiability of velocity fields...
May 2017: Physical Review. E
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