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https://www.readbyqxmd.com/read/28432516/the-tower-of-london-tol-in-italy-standardization-of-the-tol-test-in-an-italian-population
#1
Maddalena Boccia, Dario Marin, Giovanni D'Antuono, Paola Ciurli, Chiara Incoccia, Gabriella Antonucci, Cecilia Guariglia, Laura Piccardi
Deficit in planning and problem-solving, affecting a wide range of neuropsychological patients, has been widely investigated using the Tower of London (ToL) test, as developed by Shallice (Philos Trans R Soc Lond Ser B Biol Sci 298:199-209, 1). The ToL taps on several executive functions (EF), such as planning, time for planning or rule breaks, which may be usefully indexed by different ToL measurements. However, in its original version, the different aspects involved in ToL are not evaluated in a specific way...
April 21, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28430824/suppressors-of-cytokine-signaling-in-tuberculosis
#2
Shih-Wei Lee, Chi-Wei Liu, Jia-Ying Hu, Li-Mei Chiang, Chih-Pin Chuu, Lawrence Shih-Hsin Wu, Yung-Hsi Kao
Tuberculosis (TB), a global disease mainly infected by Mycobacterium tuberculosis, remains leading public health problem worldwide. Suppressors of cytokine signaling (SOCSs) play important roles in the protection against microbial infection. However, the relationship between members of the SOCS family and tuberculosis infection remains unclear. Using peripheral blood mononuclear cells, we investigated the mRNA expression profiles of SOCS subfamilies among active TB, latent tuberculosis infection (LTBI), and healthy individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28430515/scattering-theory-on-surface-majorana-fermions-by-an-impurity-in-3-he-b
#3
Yasumasa Tsutsumi
We have formulated the scattering theory on Majorana fermions emerging in the surface bound state of the superfluid ^{3}He B phase (^{3}He-B) by an impurity. By applying the theory to the electron bubble, which is regarded as the impurity, trapped below a free surface of ^{3}He-B, the observed mobility of the electron bubble [J. Phys. Soc. Jpn. 82, 124607 (2013)JUPSAU0031-901510.7566/JPSJ.82.124607] is quantitatively reproduced. The mobility is suppressed in low temperatures from the expected value in the bulk ^{3}He-B by the contribution from the surface Majorana fermions...
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28429833/the-microbially-mediated-soil-organic-carbon-loss-under-degenerative-succession-in-an-alpine-meadow
#4
Yuguang Zhang, Xiao Liu, Jing Cong, Hui Lu, Yuyu Sheng, Xiulei Wang, Diqiang Li, Xueduan Liu, Huaqun Yin, Jizhong Zhou, Ye Deng
Land-cover change has long been recognized as having marked effect on the amount of soil organic carbon (SOC). However, the microbially-mediated processes and mechanisms on SOC are still unclear. In this study, the soil samples in a degenerative succession from alpine meadow to alpine steppe meadow in the Qinghai-Tibetan Plateau were analyzed using high-throughput technologies, including Illumina sequencing and GeoChip functional gene arrays. The soil microbial community structure and diversity were significantly (P < 0...
April 21, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28426800/neutrophil-lymphocyte-ratio-predicts-short-term-mortality-in-patients-with-hepatitis-b-virus-related-acute-on-chronic-liver-failure-treated-with-an-artificial-liver-support-system
#5
Zeng Fan, Chen EnQiang, Du Ling Yao, Yan LiBo, Li Hong, Bai Lang, Feng Ping, Tang Hong
AIM: Hepatitis B virus-related acute-on-chronic liver failure has high short-term mortality. Artificial liver support systems (ALSS) may improve outcome and avoid liver transplantation, but predicting short-term prognosis in such patients is difficult. This study aimed to determine whether the neutrophil-lymphocyte ratio (NLR), an inflammation marker, predicted mortality in patients treated with ALSS. METHODS: A total of 560 patients with hepatitis B virus-related acute-on-chronic liver failure were enrolled, 338 were treated with ALSS and the others treated with standard of care(SOC)...
2017: PloS One
https://www.readbyqxmd.com/read/28425903/improving-linkage-to-hiv-care-at-low-threshold-sti-hiv-testing-sites-an-evaluation-of-the-immediate-staging-pilot-project-in-vancouver-british-columbia
#6
Bobbi Brownrigg, Darlene Taylor, Felicia Phan, Irvine Sandstra, Rochelle Stimpson, Rolando Barrios, Richard Lester, Gina Ogilvie
OBJECTIVES: The objective of the Immediate Staging Pilot Project (ISPP) was to improve linkage to human immunodeficiency virus (HIV) care by increasing the number of referrals made to HIV care, and to decrease the time between diagnosis and linkage to care for newly diagnosed HIV clients. This pilot had the potential to decrease HIV transmission at a population level by engaging clients in treatment earlier. SETTING: The Bute Street Clinic and Health Initiative for Men Clinic on Davie in Vancouver, British Columbia are low-threshold public health facilities providing HIV/STI testing primarily to men who have sex with men (MSM)...
April 20, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28425724/factors-impacting-sense-of-community-among-adults-with-brain-injury
#7
Nicole Ditchman, Fong Chan, Christopher Haak, Amanda B Easton
PURPOSE: Despite increasing interest in examining community outcomes following disability, sense of community (SOC) has received relatively no attention in the rehabilitation literature. SOC refers to feelings of belonging and attachment one has for a community and is of particular relevance for people with brain injury who are at increased risk of social isolation. The aim of this study was to investigate factors contributing to SOC for individuals with brain injury. METHOD: Members from 2 brain injury associations (n = 98) participated in this survey-based study...
April 20, 2017: Rehabilitation Psychology
https://www.readbyqxmd.com/read/28424945/date-palm-waste-biochars-alter-a-soil-respiration-microbial-biomass-carbon-and-heavy-metal-mobility-in-contaminated-mined-soil
#8
Mohammad I Al-Wabel, Adel Rabie A Usman, Abdullah S Al-Farraj, Yong Sik Ok, Adel Abduljabbar, Abdulelah I Al-Faraj, Abdelazeem S Sallam
A 30-day incubation experiment was conducted using a heavy metal-contaminated mined soil amended with date palm feedstock (FS) and its derivative biochars (BCs) at three pyrolysis temperatures of 300 (BC-300), 500 (BC-500), and 700 °C (BC-700) with different application rates (0.0, 5, 15, and 30 g kg(-1)) to investigate their short-term effects on soil respiration (CO2-C efflux), microbial biomass carbon (MBC), soil organic carbon (SOC), mobile fraction of heavy metals (Cd, Cu, Pb, Zn, Mn, and Fe), pH, and electrical conductivity (EC)...
April 19, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28423702/experience-with-precision-genomics-and-tumor-board-indicates-frequent-target-identification-but-barriers-to-delivery
#9
Alan H Bryce, Jan B Egan, Mitesh J Borad, A Keith Stewart, Grzegorz S Nowakowski, Asher Chanan-Khan, Mrinal M Patnaik, Stephen M Ansell, Michaela S Banck, Steven I Robinson, Aaron S Mansfield, Eric W Klee, Gavin R Oliver, Jennifer B McCormick, Norine E Huneke, Colleen M Tagtow, Robert B Jenkins, Kandelaria M Rumilla, Sarah E Kerr, Jean-Pierre A Kocher, Scott A Beck, Martin E Fernandez-Zapico, Gianrico Farrugia, Konstantinos N Lazaridis, Robert R McWilliams
BACKGROUND: The ability to analyze the genomics of malignancies has opened up new possibilities for off-label targeted therapy in cancers that are refractory to standard therapy. At Mayo Clinic these efforts are organized through the Center for Individualized Medicine (CIM). RESULTS: Prior to GTB, datasets were analyzed and integrated by a team of bioinformaticians and cancer biologists. Therapeutically actionable mutations were identified in 65% (92/141) of the patients tested with 32% (29/92) receiving genomically targeted therapy with FDA approved drugs or in an independent clinical trial with 45% (13/29) responding...
March 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421561/a-new-mexican-species-of-orizabus-fairmaire-coleoptera-scarabaeidae-dynastinae-pentodontini-with-a-key-to-the-species-of-the-genus
#10
M M López-García, H J Gasca-Álvarez, C Deloya
A new Orizabus species is described from Chilapa de Álvarez in the state of Guerrero (Mexico). The new species is similar to Orizabus rawlinsi Dechambre Bull Soc Entomol Fr 98:342, 1993, which is known from the state of Oaxaca but differs in the pygidial punctation, and the shape of the marginal pronotal bead and the parameres. A revised identification key to Orizabus species is provided.
April 18, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/28419615/involvement-of-herpes-simplex-virus-type-1-ul13-protein-kinase-in-the-induction-of-socs-genes-the-negative-regulator-of-cytokine-signaling
#11
Yuka Sato, Tetsuo Koshizuka, Kei Ishibashi, Koichi Hashimoto, Ken Ishioka, Kazufumi Ikuta, Shin-Ichi Yokota, Nobuhiro Fujii, Tatsuo Suzutani
The suppressor of cytokine signaling (SOCS) family consists of 8 members and suppresses various cytokine signaling pathways including interferon (IFN) signaling. Therefore, some viruses have evolved molecular mechanisms to induce SOCS proteins in order to escape from host immunity. Herpes simplex virus type 1 (HSV-1) has a mechanism for escaping from type I IFN by induction of SOCS1 and SOCS3 as well. In this study, expression of 8 members of the SOCS family by HSV-1 infection was comparatively analyzed by quantitative reverse transcription PCR...
April 17, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28418165/physical-activities-impact-sense-of-coherence-among-community-dwelling-older-adults
#12
Takafumi Monma, Fumi Takeda, Tomohiro Okura
AIM: The objective of the present study was to investigate bidirectional longitudinal relationships between sense of coherence (SOC) and physical activities (PA) among community-dwelling older adults. METHODS: Self-administered questionnaires were sent to 508 community-dwelling adults aged 65-85 years who expressed their intention to participate in our surveys including cognitive function tests and physical performance tests. Of these, 427 people responded to the baseline survey, and 223 of them participated in the follow-up survey 1 year later...
April 18, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28417320/patient-reporting-in-the-eu-analysis-of-eudravigilance-data
#13
Marin Banovac, Gianmario Candore, Jim Slattery, Francois Houÿez, David Haerry, Georgy Genov, Peter Arlett
INTRODUCTION: New pharmacovigilance legislation was adopted in the EU in 2010 and became operational in July 2012. The legislation placed an obligation on all national competent authorities (NCAs) and marketing authorisation holders (MAHs) to record and report cases of suspected adverse drug reactions (ADRs) received from patients. OBJECTIVES: This descriptive study aims to provide insight into patient reporting for the totality of the EU by querying the EudraVigilance (EV) database for the period of 3 years before the new pharmacovigilance legislation became operational and the 3 years after as well as comparing patient reports with those from healthcare professionals (HCPs) where feasible...
April 17, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28417016/hmgb1-release-by-h2o2-induced-hepatocytes-is-regulated-through-calcium-overload-and-58-f-interference
#14
Pei Zhao, Tingjie Ye, Xiaofeng Yan, Xudong Hu, Ping Liu, Xiaoling Wang
HMGB1 is passively released by injured or dying cells and aggravates inflammatory processes. The release of HMGB1 and calcium overload have each been reported to be important mediators of H2O2-induced injury. However, a potential connection between these two processes remains to be elucidated. In the present study, we employed H2O2-induced hepatocytes to investigate how calcium overload takes place during cellular injury and how the extracellular release of HMGB1 is regulated by this overload. In addition, we investigated the use of 58-F, a flavanone extracted from Ophiopogon japonicus, as a potential therapeutic drug...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28416080/molecular-identification-and-immunological-characteristics-of-goose-suppressor-of-cytokine-signaling-1-socs-1-in-vitro-and-vivo-following-dtmuv-challenge
#15
Wei Zhang, Shun Chen, Jingyue Zhang, Zhen Wu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Kunfeng Sun, Qiao Yang, Ying Wu, Xiaoyue Chen, Anchun Cheng
Purpose suppressor of cytokine signaling 1 (SOCS-1) is inducible feedback inhibitors of cytokine signaling and involved in viral infection through regulation of both innate and adaptive immunity. In this study, we firstly cloned SOCS-1 (goSOCS-1) from duck Tembusu virus (DTMUV) infected goose. The full-length sequence of goSOCS-1 ORF is 624bp and encoded 108 amino acids. Structurally, the mainly functional regions (KIR, SH2, SOCS-box) were conserved between avian and mammalian. The tissues distribution data showed SOCS-1 highly expressed in immune related tissues (SP, LU, HG) of both gosling and adult goose...
April 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28415359/experimental-investigation-of-the-effect-of-thresholding-on-temporal-statistics-of-avalanches
#16
M A Lebyodkin, I V Shashkov, T A Lebedkina, V S Gornakov
Avalanchelike behavior reflected in power-law statistics is a ubiquitous property of extended systems addressed in a number of generic models. The paper presents an experimental investigation of the effect of thresholding on the statistics of durations and waiting times between avalanches using acoustic emission accompanying unstable plastic deformation. It is found that durations of acoustic events obey power-law statistical distributions robust against thresholding. The quiescent time distributions follow the Poisson law for low threshold values...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28415295/emergence-of-l%C3%A3-vy-walks-in-systems-of-interacting-individuals
#17
Sergei Fedotov, Nickolay Korabel
We propose a model of superdiffusive Lévy walk as an emergent nonlinear phenomenon in systems of interacting individuals. The aim is to provide a qualitative explanation of recent experiments [G. Ariel et al., Nat. Commun. 6, 8396 (2015)2041-172310.1038/ncomms9396] revealing an intriguing behavior: swarming bacteria fundamentally change their collective motion from simple diffusion into a superdiffusive Lévy walk dynamics. We introduce microscopic mean-field kinetic equations in which we combine two key ingredients: (1) alignment interactions between individuals and (2) non-Markovian effects...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28413349/comment-on-are-some-people-suffering-as-a-result-of-increasing-mass-exposure-of-the-public-to-ultrasound-in-air
#18
COMMENT
T G Leighton
A number of queries regarding the paper 'Are some people suffering as a result of increasing mass exposure of the public to ultrasound in air?' (Leighton 2016 Proc. R. Soc. A472, 20150624 (doi:10.1098/rspa.2015.0624)) have been sent in from readers, almost all based around some or all of a small set of questions. These can be grouped into issues of engineering, human factors and timeliness. Those issues (represented by the most typical wording used in queries) and my responses are summarized in this comment...
March 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28413105/investigation-of-omnigene%C3%A2-sputum-performance-in-delayed-tuberculosis-testing-by-smear-culture-and-xpert-mycobacterium-tuberculosis-rif-assays-in-uganda
#19
Cassandra D Kelly-Cirino, P S Curry
OMNIgene·SPUTUM (OM-S) is a sample transport reagent designed to work with all tuberculosis diagnostics while eliminating the need for cold chain. OM-S-treated sputum samples were assayed in several tests after multiday holds. Raw sputa from 100 patients underwent direct smear microscopy, were manually split and assigned to the OM-S group [OM-S added at collection (no other processing required) and tested after 0- to 5-day holds at room temperature] or standard-of-care (SOC) group (NaOH/N-acetyl l-cysteine decontamination, all tested on day of collection)...
April 13, 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/28410454/transcriptomic-analysis-of-host-immune-response-in-the-skin-of-chickens-infected-with-marek-s-disease-virus
#20
Mohammad Heidari, Phillip C Delekta
Marek's disease virus (MDV), a highly cell-associated oncogenic α-herpesvirus, is the causative agent of T cell lymphoma and neuropathic disease called Marek's disease. The skin is the only anatomical site where infectious enveloped cell-free virions are produced and shed into the environment. Studies have demonstrated that MDV infection induces immunological responses within the skin, including the release of cytokines and the recruitment of T lymphocytes. The host immune response, however, is not sufficient to block replication and shedding of the virus particles from the skin...
April 14, 2017: Viral Immunology
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