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REVIEW
Emanuel Tenório Paulino
The cardiovascular system is mainly responsible for the transport of substances necessary to cellular metabolism. However, for the good performance of this function, there is need for adequate control of blood pressure levels of tissue perfusion and systemic arterial. Acute myocardial infarction is one of the complications of the cardiovascular system, that most affects the population around the world. This condition can be defined as a disease generated by an imbalance of oxygen concentrations used in cardiovascular metabolism, this change usually occurs because coronary occlusion, which prevents myocardial blood flow...
February 21, 2024: Current Problems in Cardiology
#22
JOURNAL ARTICLE
Yangduo Wang, Shicheng Chen, Wenzheng Shi, Shuji Liu, Xiaoting Chen, Nan Pan, Xiaoyan Wang, Yongchang Su, Zhiyu Liu
Protein hydrolysates from sea cucumber ( Apostichopus japonicus ) gonads are rich in active materials with remarkable angiotensin-converting enzyme (ACE) inhibitory activity. Alcalase was used to hydrolyze sea cucumber gonads, and the hydrolysate was separated by the ultrafiltration membrane to produce a low-molecular-weight peptide component (less than 3 kDa) with good ACE inhibitory activity. The peptide component (less than 3 kDa) was isolated and purified using a combination method of ACE gel affinity chromatography and reverse high-performance liquid chromatography...
February 16, 2024: Marine Drugs
#23
JOURNAL ARTICLE
Prerna Gupta, Mario Enrico Canonico, Christian Faaborg-Andersen, Nicole Prabhu, Lavanya Kondapalli, Raymundo A Quintana
PURPOSE OF REVIEW: To provide a comprehensive review of hypertension among patients with cancer. Several cancer therapies cause hypertension which has resulted in a growing and vulnerable population of patients with difficult to control hypertension which has significant downstream effects. RECENT FINDINGS: Hypertension affects up to 50% of cancer patients and higher comorbidity when compared to the general population. Many anticancer therapies can cause hypertension through their treatment effect...
February 26, 2024: Current Opinion in Cardiology
#24
JOURNAL ARTICLE
Masaya Yamato, Masahiro Kinoshita, Shogo Miyazawa, Masayuki Seki, Tomoki Mizuno, Takuhiro Sonoyama
Antivirals with proven effectiveness against the Omicron SARS-CoV-2 variant are required for COVID-19 treatment in hospitalized patients, particularly those with severe underlying conditions. Ensitrelvir, a 3C-like protease inhibitor, received emergency approval in Japan in November 2022, based on evidence of rapid symptom resolution in non-hospitalized patients, but confirmation of its effectiveness in hospitalized patients is lacking. This retrospective chart review reports outcomes for all patients who received ensitrelvir whilst hospitalized with SARS-CoV-2 infection at Rinku General Medical Center, Japan (November 2022-April 2023)...
February 15, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#25
REVIEW
John M Flack, Michael G Buhnerkempe, Kenneth Todd Moore
PURPOSE OF REVIEW: To define resistant hypertension (RHT), review its pathophysiology and disease burden, identify barriers to effective hypertension management, and to highlight emerging treatment options. RECENT FINDINGS: RHT is defined as uncontrolled blood pressure (BP) ≥ 130/80 mm Hg despite concurrent prescription of ≥ 3 or ≥ 4 antihypertensive drugs in different classes or controlled BP despite prescription of ≥ to 4 drugs, at maximally tolerated doses, including a diuretic...
February 16, 2024: Current Hypertension Reports
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JOURNAL ARTICLE
Ribot Fleury T Ceskoutsé, Alain Bertrand Bomgni, David R Gnimpieba Zanfack, Diing D M Agany, Thomas Bouetou Bouetou, Etienne Gnimpieba Zohim
Stroke is one of the leading causes of death worldwide. Previous studies have explored machine learning techniques for early detection of stroke patients using content-based recommendation systems. However, these models often struggle with timely detection of medications, which can be critical for patient management and decision-making regarding the prescription of new drugs. In this study, we developed a content-based recommendation model using three machine learning algorithms: Gaussian Mixture Model (GMM), Affinity Propagation (AP), and K-Nearest Neighbors (KNN), to aid Healthcare Professionals (HCP) in quickly detecting medications based on the symptoms of a patient with stroke...
March 2024: Computers in Biology and Medicine
#27
JOURNAL ARTICLE
Gonzalo Hernandez-Hernandez, Samantha C O'Dwyer, Pei-Chi Yang, Collin Matsumoto, Mindy Tieu, Zhihui Fong, Timothy J Lewis, L Fernando Santana, Colleen E Clancy
The function of the smooth muscle cells lining the walls of mammalian systemic arteries and arterioles is to regulate the diameter of the vessels to control blood flow and blood pressure. Here, we describe an in silico model, which we call the 'Hernandez-Hernandez model', of electrical and Ca2+ signaling in arterial myocytes based on new experimental data indicating sex-specific differences in male and female arterial myocytes from murine resistance arteries. The model suggests the fundamental ionic mechanisms underlying membrane potential and intracellular Ca2+ signaling during the development of myogenic tone in arterial blood vessels...
February 9, 2024: ELife
#28
JOURNAL ARTICLE
Eiichiro Yamamoto, Hiroki Usuku, Daisuke Sueta, Satoru Suzuki, Taishi Nakamura, Kunihiko Matsui, Kenichi Matsushita, Tomoko Iwasaki, Naritsugu Sakaino, Toshihiko Sakanashi, Kazuto Hirayama, Hirofumi Kurokawa, Koichi Kikuta, Nobuyasu Yamamoto, Koji Sato, Takanori Tokitsu, Takashi Taguchi, Kazuhito Shiosakai, Kotaro Sugimoto, Kenichi Tsujita
INTRODUCTION: In contrast to the antihypertensive effect of esaxerenone, there is little evidence of its cardioprotective effect. We investigated the efficacy and safety of esaxerenone in patients with uncontrolled hypertension and left ventricular hypertrophy taking a renin-angiotensin system inhibitor (RASi) or calcium-channel blocker (CCB). METHODS: This was a multicenter, open-label, exploratory study with a 24-week treatment period. Esaxerenone was orally administered at an initial dose of 2...
February 4, 2024: Advances in Therapy
#29
JOURNAL ARTICLE
Milica Jovanović, Slobodan Janković, Nemanja Okičić, Andjela Milojević Šamanović, Marko Milosavljević
BACKGROUND/PURPOSE: Decubital lesions or traumatic ulcers caused by dentures usually appear one or two day(s) after new dentures placement due to mismatch of the microrelief of the tissue and the microrelief of the gingival surface of the prosthesis. The study aimed to analyze factors that could influence the healing of ulcers during a one-week period after the placement of new partial and complete dentures. MATERIALS AND METHODS: The prospective cohort study included 60 patients with new denture-induced traumatic ulcers...
January 2024: Journal of Dental Sciences
#30
JOURNAL ARTICLE
Milica Radosavljevic, Danijela Vučević, Janko Samardžić, Miroslav Radenkovic, Tatjana Radosavljević
Arterial hypertension (AH) is recognized as the most common illness within the group of cardiovascular diseases and the most massive chronic non-infectious disease in the world. The number of hypertensive patients worldwide has reached 1.28 billion, contributing to an increase in cardiovascular diseases and premature death globally. The high prevalence of hypertension emphasizes the importance of effectively treating this condition. Elevated blood pressure often leads to lethal complications (heart failure, stroke, renal disorders, etc...
January 31, 2024: Current Medicinal Chemistry
#31
JOURNAL ARTICLE
Qianyin Zhu, Tingyu Mu, Die Dong, Lingshan Chen, Jiayi Xu, Cuizhen Shen
BACKGROUND: Phlegm-dampness constitution is a traditional Chinese medicine constitution typically associated with essential hypertension. Previous studies have demonstrated that auricular acupuncture effectively decreases blood pressure and adjusts the constitution. However, the mechanism underlying auricular acupuncture's effect is poorly understood. METHODS: A non-blinded, randomized controlled trial will be undertaken between September 2022 and May 2023. Eighty essential hypertensive patients with a phlegm-dampness constitution will be randomly allocated to one of two groups...
2024: PloS One
#32
JOURNAL ARTICLE
Paola Parra Ramírez, Patricia Martín Rojas-Marcos, Miguel Paja Fano, Margarita González-Boillos, Eider Pascual-Corrales, Ana María García Cano, Jorge Gabriel Ruiz-Sanchez, Almudena Vicente Delgado, Emilia Gómez Hoyos, Rui Ferreira, Iñigo García Sanz, Mònica Recasens Sala, Rebeca Barahona San Millan, María José Picón César, Patricia Díaz Guardiola, Carolina M Perdomo, Laura Manjón-Miguélez, Ángel Rebollo Román, Cristina Robles Lázaro, Manuel Morales-Ruiz, María Calatayud, Simone Andree Furio Collao, Diego Meneses, Miguel Antonio Sampedro-Nuñez, Elena Mena Ribas, Alicia Sanmartín Sánchez, Cesar Gonzalvo Diaz, Cristina Lamas, Raquel Guerrero-Vázquez, María Del Castillo Tous, Joaquín Serrano Gotarredona, Theodora Michalopoulou Alevras, Susana Tenés Rodrigo, Ricardo Roa Chamorro, Fernando Jaen Aguila, Eva María Moya Mateo, Felicia A Hanzu, Marta Araujo-Castro
INTRODUCTION: Primary aldosteronism (PA) is associated with several cardiometabolic comorbidities. Specific treatment by mineralocorticoid receptor antagonists (MRA) or adrenalectomy has been reported to reduce the cardiometabolic risk. However, the cardiovascular benefit could depend on plasma renin levels in patients on MRA. AIM: To compare the development of cardiovascular, renal and metabolic complications between medically treated patients with PA and those who underwent adrenalectomy, taking the renin status during MRA treatment into account...
January 16, 2024: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
#33
JOURNAL ARTICLE
Xing-Jiang Xiong, Peng-Qian Wang, Kui-Wu Yao, Jing-le Hou
Hypertension, a primary cause of cardiovascular and cerebrovascular events, has become a major global public health problem and caused a heavy burden of health economics on the society. In "the 20 Most Important and Most Preventable Health Problems" released by the Chinese Academy of Engineering, hypertension was ranked the second. Due to the disease complexity, many hypertension patients need to take antihypertensive drugs for life. Although significant progress has been achieved in blood pressure lowering by western medicines, the problems including adverse reactions, poor compliance due to long-term medication, and ineffective mitigation in clinical symptoms related to hypertension remain to be addressed...
December 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#34
REVIEW
Carmine Zoccali, Francesca Mallamaci, Luca De Nicola, Roberto Minutolo
Resistant hypertension (RH) is linked to an increased risk of cardiovascular and renal complications. Treatment options include non-pharmacological interventions, such as lifestyle modifications, and the use of specific antihypertensive drug combinations, including diuretics. Renal denervation is another option for treatment-resistant hypertension. New compounds targeting different pathways involved in RH-including inhibitors of aminopeptidase A, endothelin antagonists and selective aldosterone synthase inhibitors-have been tested in clinical trials in this condition...
January 2024: Clinical Kidney Journal
#35
JOURNAL ARTICLE
Liguo Lang, Jianying Zhang, Huanmin Gao
Antiplatelet, antihypertensive, and lipid-lowering agents are the three foundational agents for secondary prevention of ischemic stroke, among which lipid-lowering is one of the most important cornerstones. Probucol is a potent antioxidative lipid-lowering drug used to prevent and treat atherosclerotic cardiovascular diseases and xanthomas. However, it has faded from Western markets by lowering LDL-C and HDL-C levels. Probucol alleviates atherosclerosis improving high-density lipoprotein function, and does not increase the risk of cardiovascular events...
January 4, 2024: Current Medicinal Chemistry
#36
JOURNAL ARTICLE
Stephanie W Watts, Raymond R Townsend, Richard R Neubig
Many hypertension therapeutics were developed prior to major advances in drug receptor theory. Moreover, newer drugs may take advantage of some of the newly understood modalities of receptor function. The goal of this review is to provide an up-to-date summary of drug-receptor theory. This is followed by discussion of the drug classes recognized for treating hypertension to which new concepts in receptor theory apply. We raise ideas for mechanisms of potential new antihypertensive drugs and whether they may take advantage of new theories in drug-receptor interaction...
December 27, 2023: American Journal of Hypertension
#37
JOURNAL ARTICLE
E A Shirokov
Modern strategies for secondary prevention of ischemic stroke (IS) are based on long-term use of drugs from three main pharmaceutical groups (antihypertensive, lipid-lowering and antithrombotic drugs). In practical terms, the most difficult thing for a practitioner is the choice of antithrombotic therapy with anticoagulants or antiplatelet agents. Antithrombotic therapy for patients with acute cerebrovascular accidents has changed significantly in recent years. Clinical guidelines mention traditional and new oral anticoagulants, and the family of antiplatelet agents that can be used in clinical practice has expanded...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#38
JOURNAL ARTICLE
Hadil Faris Alotaibi, Haifa Alotaibi, Khaled M Darwish, El-Sayed Khafagy, Amr S Abu Lila, Mohamed A M Ali, Wael A H Hegazy, Samar Zuhair Alshawwa
The development of bacterial resistance is an increasing global concern that requires discovering new antibacterial agents and strategies. Bacterial quorum sensing (QS) systems play important roles in controlling bacterial virulence, and their targeting could lead to diminishing bacterial pathogenesis. In this context, targeting QS systems without significant influence on bacterial growth is assumed as a promising strategy to overcome resistance development. This study aimed at evaluating the anti-QS and anti-virulence activities of the β-adrenoreceptor antagonist propranolol at sub-minimal inhibitory concentrations (sub-MIC) against two Gram-negative bacterial models Pseudomonas aeruginosa and Serratia marcescens ...
November 28, 2023: Biomedicines
#39
JOURNAL ARTICLE
Miguel Camafort, Reinhold Kreutz, Myeong-Chan Cho
Resistant hypertension is a condition where blood pressure levels remain elevated above target despite changes in lifestyle and concurrent use of at least three antihypertensive agents, including a long-acting calcium channel blocker (CCB), a blocker of the renin-angiotensin system (ACE inhibitor or angiotensin receptor blocker) and a diuretic. To be diagnosed as resistant hypertension, maintaining adherence to therapy is required along with confirmation of blood pressure levels above target by out-of-office blood pressure measurements and exclusion of secondary causes of hypertension...
December 22, 2023: Heart
#40
JOURNAL ARTICLE
Niklas Worm Andersson, Jan Wohlfahrt, Bjarke Feenstra, Anders Hviid, Mads Melbye, Marie Lund
BACKGROUND: According to drug labels, the frequency of thiazide-induced hyponatremia is unknown or uncommon to very rare (that is, <1 in 10 000 to <1 in 100), but the exact burden remains unclear. OBJECTIVE: To estimate the increase in the cumulative incidence of hyponatremia using thiazide diuretics compared with nonthiazide antihypertensive drugs in routine clinical practice. DESIGN: Population and register-based cohort study using target trial emulation...
January 2024: Annals of Internal Medicine
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