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https://www.readbyqxmd.com/read/28110380/iscev-standard-for-clinical-electro-oculography-2017-update
#1
Paul A Constable, Michael Bach, Laura J Frishman, Brett G Jeffrey, Anthony G Robson
The clinical electro-oculogram (EOG) is an electrophysiological test of the outer retina and retinal pigment epithelium (RPE) in which changes in the electrical potential across the RPE are recorded during successive periods of dark and light adaptation. This document presents the 2017 EOG Standard from the International Society for Clinical Electrophysiology of Vision (ISCEV: www.iscev.org ). This standard has been reorganized and updated to include an explanation of the mechanism of the EOG, but without substantive changes to the testing protocol from the previous version published in 2011...
January 21, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28110316/insensitivity-of-pi3k-akt-gsk3-signaling-in-peripheral-blood-mononuclear-cells-of-age-related-macular-degeneration-patients
#2
Liu Xunxian, Yao Zemin
Our recent studies with cultured retinal pigment epithelium cells suggested that overexpression of interleukin 17 receptor C (IL-17RC), a phenomenon observed in peripheral blood and chorioretinal tissues with age-related macular degeneration (AMD), was associated with altered activation of phosphatidylinositide 3-kinase (PI3K), Akt, and glycogen synthase kinase 3 (GSK3). We wondered whether or not altered PI3K, Akt, and GSK3 activities could be detected in peripheral blood mononuclear cells (PBMC) obtained from AMD patients...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28109959/crispr-cas9-mediated-genome-editing-as-a-therapeutic-approach-for-leber-congenital-amaurosis-10
#3
Guo-Xiang Ruan, Elizabeth Barry, Dan Yu, Michael Lukason, Seng H Cheng, Abraham Scaria
As the most common subtype of Leber congenital amaurosis (LCA), LCA10 is a severe retinal dystrophy caused by mutations in the CEP290 gene. The most frequent mutation found in patients with LCA10 is a deep intronic mutation in CEP290 that generates a cryptic splice donor site. The large size of the CEP290 gene prevents its use in adeno-associated virus (AAV)-mediated gene augmentation therapy. Here, we show that targeted genomic deletion using the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system represents a promising therapeutic approach for the treatment of patients with LCA10 bearing the CEP290 splice mutation...
January 18, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28109737/retinal-oxygen-from-animals-to-humans
#4
REVIEW
Robert A Linsenmeier, Hao F Zhang
This article discusses retinal oxygenation and retinal metabolism by focusing on measurements made with two of the principal methods used to study O2 in the retina: measurements of PO2 with oxygen-sensitive microelectrodes in vivo in animals with a retinal circulation similar to that of humans, and oximetry, which can be used non-invasively in both animals and humans to measure O2 concentration in retinal vessels. Microelectrodes uniquely have high spatial resolution, allowing the mapping of PO2 in detail, and when combined with mathematical models of diffusion and consumption, they provide information about retinal metabolism...
January 18, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28109563/imaging-protocols-in-clinical-studies-in-advanced-age-related-macular-degeneration-recommendations-from-classification-of-atrophy-consensus-meetings
#5
Frank G Holz, SriniVas R Sadda, Giovanni Staurenghi, Moritz Lindner, Alan C Bird, Barbara A Blodi, Ferdinando Bottoni, Usha Chakravarthy, Emily Y Chew, Karl Csaky, Christine A Curcio, Ron Danis, Monika Fleckenstein, K Bailey Freund, Juan Grunwald, Robyn Guymer, Carel B Hoyng, Glenn J Jaffe, Sandra Liakopoulos, Jordi M Monés, Akio Oishi, Daniel Pauleikhoff, Philip J Rosenfeld, David Sarraf, Richard F Spaide, Ramin Tadayoni, Adnan Tufail, Sebastian Wolf, Steffen Schmitz-Valckenberg
PURPOSE: To summarize the results of 2 consensus meetings (Classification of Atrophy Meeting [CAM]) on conventional and advanced imaging modalities used to detect and quantify atrophy due to late-stage non-neovascular and neovascular age-related macular degeneration (AMD) and to provide recommendations on the use of these modalities in natural history studies and interventional clinical trials. DESIGN: Systematic debate on the relevance of distinct imaging modalities held in 2 consensus meetings...
January 18, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28108907/peripapillary-retinal-nerve-fiber-layer-and-ganglion-cell-inner-plexiform-layer-thickness-in-adult-onset-familial-mediterranean-fever
#6
Sait Alim, Mehmet Esen, Ayşe Kevser Demir, Selim Demir, Hüseyin Ortak, Alper Güneş, Tufan Alatli, Helin Deniz Demir
OBJECTIVE: The purpose of the present study was to evaluate the thickness of the peripapillary retinal nerve fiber layer (RNFL) and retinal ganglion cell-inner plexiform layer (GCIPL) in adult-onset familial Mediterranean fever (FMF). METHODS: Forty two adult-onset FMF patients and forty two healthy controls were included in the present study. Detailed ocular examination was performed, and then the thickness of the peripapillary RNFL and GCIPL was measured by Spectral domain optical coherence tomography...
January 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28108905/the-assessment-of-macular-electrophysiology-and-macular-morphology-in-patients-with-vitiligo
#7
Rukiye Aydin, Mustafa Ozsutcu, Sevil Karaman Erdur, Funda Dikkaya, Ali Balevi, Merve Ozbek, Fevzi Senturk
PURPOSE: We aimed to analyze the electrophysiologic function and morphology of macula in vitiligo patients. METHODS: Seventeen patients with vitiligo and 11 healthy subjects were studied. All participants underwent multifocal electroretinography (mfERG) and spectral domain optical coherence tomography (SD-OCT) evaluations. The mfERG (P1 mfERG responses central and peripheral) and retinal layer segmentation parameters (nine ETDRS subfields) were compared in vitiligo and control groups...
January 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28108900/a-case-study-of-ciliary-detachment-with-primary-pulmonary-hypertension
#8
Zhuolei Feng, Li Dong, Junxian Cao, Jie Bai, Ming-Ming Yang, Yi Zheng, Daohong Lin
PURPOSE: To introduce a case of ciliary detachment with primary pulmonary hypertension (PPH). METHODS: The clinical manifestations of a case of ciliary detachment with PPH were addressed by comprehensive examination including ultrasound biological microscope (UBM), intraocular pressure, color fundus photographs, fluorescence fundus angiography (FFA). In addition, echocardiography is used to measure primary pulmonary pressure. RESULTS: When the echocardiography displayed a systolic pulmonary arterial pressure of 106 mmHg, UBM exhibited ciliochoroidal detachment, as well as peripheral retinal effusion and non-perfusion areas in FFA...
January 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28108670/retinal-temporal-resolution-and-contrast-sensitivity-in-the-parasitic-lamprey-mordacia-mordax-and-its-non-parasitic-derivative-m-praecox
#9
Rachael E Warrington, Nathan S Hart, Ian C Potter, Shaun P Collin, Jan M Hemmi
Lampreys and hagfishes are the sole extant representatives of the early agnathan (jawless) vertebrates. We compared retinal function of fully-metamorphosed, immature Mordacia mordax (which are about to commence parasitic feeding) with those of sexually-mature individuals of its non-parasitic derivative M praecox We focused on elucidating the retinal adaptations to dim-light environments in these nocturnally-active lampreys, using electroretinography to determine the temporal resolution (flicker fusion frequency, FFF) and temporal contrast sensitivity (CS) of enucleated eyecups at different temperatures and light intensities...
January 20, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28108570/retinal-sensitivity-changes-associated-with-diabetic-neuropathy-in-the-absence-of-diabetic-retinopathy
#10
Srividya Neriyanuri, Shahina Pardhan, Laxmi Gella, Sakshyar Saumya Pal, Suganeswari Ganesan, Tarun Sharma, Rajiv Raman
PURPOSE: To explore any relationship between the markers of early retinal neuronal damage and peripheral diabetic neuropathy in subjects with no diabetic retinopathy (DR). METHODS: A cross-sectional study in which type 2 diabetic subjects (n=743) without DR were studied. Visual functions including visual acuity, contrast sensitivity, colour vision, retinal sensitivity using microperimeter and retinal thicknesses by spectral domain optical coherence tomography were measured...
January 20, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28108569/five-year-progression-of-unilateral-age-related-macular-degeneration-to-bilateral-involvement-the-three-continent-amd-consortium-report
#11
Nichole Joachim, Johanna Maria Colijn, Annette Kifley, Kristine E Lee, Gabriëlle H S Buitendijk, Barbara E K Klein, Chelsea E Myers, Stacy M Meuer, Ava G Tan, Elizabeth G Holliday, John Attia, Gerald Liew, Sudha K Iyengar, Paulus T V M de Jong, Albert Hofman, Johannes R Vingerling, Paul Mitchell, Caroline C W Klaver, Ronald Klein, Jie Jin Wang
PURPOSE: To assess the 5-year progression from unilateral to bilateral age-related macular degeneration (AMD) and associated risk factors. DESIGN: Pooled data analyses of three prospective population-based cohorts, the Blue Mountains Eye Study, Beaver Dam Eye Study and Rotterdam Study. METHODS: Retinal photography and interview with comprehensive questionnaires were conducted at each visit of three studies. AMD was assessed following the modified Wisconsin AMD grading protocol...
January 20, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28108378/the-pressure-induced-deformation-response-of-the-human-lamina-cribrosa-analysis-of-regional-variations
#12
Dan E Midgett, Mary E Pease, Joan L Jefferys, Mohak Patel, Christian Franck, Harry A Quigley, Thao D Nguyen
: The objective of this study was to measure the pressure-induced deformation response of the human lamina cribrosa (LC) and analyze for variations with age and anatomical region. The posterior scleral cup of 8 eyes from 6 human donors was mounted onto a custom inflation chamber. A laser-scanning microscope was used for second harmonic generation (SHG), imaging the collagen structure in the posterior volume of the LC at pressures from 5 mmHg to 45 mmHg. The SHG volumes were analyzed by the Fast-Fourier Iterative Digital Volume Correlation (DVC) algorithm for the three dimensional (3D) displacement field...
January 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28107513/the-zebrafish-anillin-egfp-reporter-marks-late-dividing-retinal-precursors-and-stem-cells-entering-neuronal-lineages
#13
Meret Cepero Malo, Anne-Laure Duchemin, Luca Guglielmi, Eva Patzel, Saadettin Sel, Gerd U Auffarth, Matthias Carl, Lucia Poggi
Monitoring cycling behaviours of stem and somatic cells in the living animal is a powerful tool to better understand tissue development and homeostasis. The tg(anillin:anillin-eGFP) transgenic line carries the full-length zebrafish F-actin binding protein Anillin fused to eGFP from a bacterial artificial chromosome (BAC) containing Anillin cis-regulatory sequences. Here we report the suitability of the Anillin-eGFP reporter as a direct indicator of cycling cells in the late embryonic and post-embryonic retina...
2017: PloS One
https://www.readbyqxmd.com/read/28107485/better-visual-outcome-by-intraocular-lens-ejection-in-geriatric-patients-with-ruptured-ocular-injuries
#14
Hiroki Kaneko, Tetsu Asami, Tadasu Sugita, Taichi Tsunekawa, Toshiyuki Matsuura, Kei Takayama, Kentaro Yamamoto, Shu Kachi, Yasuki Ito, Shinji Ueno, Norie Nonobe, Keiko Kataoka, Ayana Suzumura, Takeshi Iwase, Hiroko Terasaki
Ocular trauma is one of the leading causes of visual impairment worldwide. Because of the popularity of cataract surgeries, aged individuals with ocular trauma commonly have a surgical wound in their eyes. The purpose of this study was to evaluate the visual outcome of cases that were coincident with intraocular lens (IOL) ejection in the eyes with ruptured open-globe ocular injuries. Consecutive patients with open-globe ocular injuries were first reviewed. Patients' characteristics, corrected distance visual acuities (CDVAs) over 3 years after the trauma, causes of injuries, traumatic wound patterns, and coexistence of retinal detachment were examined...
2017: PloS One
https://www.readbyqxmd.com/read/28107458/neuropilin-1-involvement-in-choroidal-and-retinal-neovascularisation
#15
Patricia Fernández-Robredo, Senthil Selvam, Michael B Powner, Dawn A Sim, Marcus Fruttiger
PURPOSE: Inhibiting VEGF is the gold standard treatment for neovascular age-related macular degeneration (AMD). It is also effective in preventing retinal oedema and neovascularisation (NV) in diabetic retinopathy (DR) and retinal vein occlusions (RVO). Neuropilin 1 (Nrp1) is a co-receptor for VEGF and many other growth factors, and therefore a possible alternative drug target in intra ocular neovascular disease. Here we assessed choroidal and retinal NV in an inducible, endothelial specific knock out model for Nrp1...
2017: PloS One
https://www.readbyqxmd.com/read/28107389/effect-of-axial-eye-length-on-retinal-vessel-parameters-in-6-to-12-year-old-malay-girls
#16
Evelyn Li Min Tai, Ling-Jun Li, Wan Hitam Wan-Hazabbah, Tien-Yin Wong, Ismail Shatriah
PURPOSE: Retinal vessel analysis is affected by both systemic and ocular factors. Malays are the major ethnicity in South East Asia. Data on the retinal microvasculature in Malays is limited, especially among children. We aim to evaluate the influence of ocular biometry on retinal vessel parameters in young Malay girls. METHODS: This was a cross-sectional, hospital-based study involving 86 Malay girls aged 6 to 12 years old in Hospital Universiti Sains Malaysia from 2015-2016...
2017: PloS One
https://www.readbyqxmd.com/read/28107073/choroidal-vasculopathy-and-retinal-detachment-in-a-bald-eagle-haliaeetus-leucocephalus-with-lead-toxicosis
#17
Ramzi Eid, David Sanchez-Migallon Guzman, Krista A Keller, K Tomo Wiggans, Christopher J Murphy, Elise E B LaDouceur, M Kevin Keel, Christopher M Reilly
A subadult male bald eagle ( Haliaeetus leucocephalus ) was presented for severe depression and weakness. Physical examination findings included depressed mentation, dehydration, sternal recumbency, poor body condition, and bilateral, whole-head, horizontal nystagmus. A heavy-metal panel was performed, and blood lead levels were 6.1 ppm. Treatment for lead poisoning was initiated, including subcutaneous fluids and parenteral calcium-disodium ethylenediaminetetraacetic acid, ceftiofur, and meloxicam. Ophthalmic examination findings included absent menace response, absent dazzle reflex, slow and incomplete direct pupillary light reflex, mild anterior uveitis, incipient cataracts, multifocal retinal tears, and retinal separation in both eyes...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28106895/identification-of-a-novel-nrl-mutation-in-a-chinese-family-with-retinitis-pigmentosa-by-whole-exome-sequencing
#18
Y Qin, F Liu, S Yu, L Yang, M Gao, Z Tang, A Y Guo, M Zhang, P Li, M Liu
No abstract text is available yet for this article.
January 20, 2017: Eye
https://www.readbyqxmd.com/read/28106889/the-incidence-and-risk-factors-for-the-development-of-vitreomacular-interface-abnormality-in-diabetic-macular-edema-treated-with-intravitreal-injection-of-anti-vegf
#19
C-K Chang, C-K Cheng, C-H Peng
PurposeTo report the incidence and associated factors for the development of vitreomacular interface abnormality (VMIA) in patients with diabetic macular edema (DME) who received intravitreal injection (IVI) of anti-VEGF (Bevacizumab and Ranibizumab) treatment.MethodsA retrospective observational study. Patients with DME followed at least 6 months were reviewed. Baseline best-corrected visual acuity (BCVA), central retinal thickness (CRT) and final BCVA, CRT in eyes with and without VMIA were compared. Multiple logistic regression was also used to investigate the risk factors of VMIA formation in patients with DME treated by anti-VEGF...
January 20, 2017: Eye
https://www.readbyqxmd.com/read/28106887/report-of-12-months-efficacy-and-safety-of-intravitreal-fluocinalone-acetonide-implant-for-the-treatment-of-chronic-diabetic-macular-oedema-a-real-world-result-in-the-united-kingdom
#20
F Alfaqawi, P L Lip, S Elsherbiny, R Chavan, A Mitra, B Mushtaq
: PurposeTo report the 12-months visual and anatomical outcomes of chronic diabetic macular oedema (DMO) treated with ILUVIEN in a real-world clinical practice in a single tertiary referral centre.MethodRetrospective data collection and analysis of consecutive 28 eyes of 23 diabetic patients received ILUVIEN implant for refractory DMO. Standard assessment included visual acuity (VA), central retinal thickness (CRT), slit-lamp biomicroscopy, and Goldmann tonometry for intraocular pressure (IOP) at 1, 6, and 12 months...
January 20, 2017: Eye
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