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https://www.readbyqxmd.com/read/28737672/mesoporous-silica-nanoparticles-as-drug-delivery-vehicles-in-cancer
#1
REVIEW
Anna Watermann, Juergen Brieger
Even though cancer treatment has improved over the recent decades, still more specific and effective treatment concepts are mandatory. Surgical removal is not always possible, metastases are challenging and chemo- and radiotherapy can not only have severe side-effects but also resistances may occur. To cope with these challenges more efficient therapies with fewer side-effects are required. One promising approach is the use of drug delivery vehicles. Here, mesoporous silica nanoparticles (MSN) are discussed as biodegradable drug carrier to improve efficacy and reduce side-effects...
July 22, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28736787/carbon-quantum-dots-with-intrinsic-mitochondrial-targeting-ability-for-mitochondria-based-theranostics
#2
Xian-Wu Hua, Yan-Wen Bao, Zhan Chen, Fu-Gen Wu
We prepare for the first time a novel type of fluorescent carbon quantum dot (or carbon dot, CD) with intrinsic mitochondrial targeting ability by a one-step hydrothermal treatment of chitosan, ethylenediamine and mercaptosuccinic acid. The as-prepared CDs can realize mitochondrial imaging and mitochondria-targeted photodynamic cancer therapy without further modifications of other mitochondriotropic ligands (such as triphenylphosphine, TPP). Currently, many commercial mitochondrial probes suffer from the lack of modifiable groups, poor photostability, short tracking time, high cost and/or complicated staining procedures, which severely limit their applications in live-cell mitochondrial imaging...
July 24, 2017: Nanoscale
https://www.readbyqxmd.com/read/28735213/chemoselective-synthesis-and-biological-evaluation-of-arylated-2-trifluoromethyl-quinolines-as-nucleotide-pyrophosphatase-npps-inhibitors
#3
David Kuhrt, Syeda Abida Ejaz, Saira Afzal, Shafi Ullah Khan, Joanna Lecka, Jean Sévigny, Peter Ehlers, Anke Spannenberg, Jamshed Iqbal, Peter Langer
A new approach to arylated 2-trifluoromethylquinolines based on novel regioselective Suzuki-Miyaura coupling reactions has been developed. Moreover, site-selective, chemo-selective amination reactions were performed. The new 2-trifluoromethylquinoline derivatives were tested as potential NPPs inhibitors and evaluated for their potential to inhibit two families of ecto-nucleotidases, i.e. NPPs and nucleoside triphosphate diphosphohydrolases (NTPDases). Several derivatives were active on a nanomolecular concentration...
July 13, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28733669/high-resolution-imaging-of-a-single-gliding-protofilament-of-tubulins-by-hs-afm
#4
Jakia Jannat Keya, Daisuke Inoue, Yuki Suzuki, Toshiya Kozai, Daiki Ishikuro, Noriyuki Kodera, Takayuki Uchihashi, Arif Md Rashedul Kabir, Masayuki Endo, Kazuki Sada, Akira Kakugo
In vitro gliding assay of microtubules (MTs) on kinesins has provided us with valuable biophysical and chemo-mechanical insights of this biomolecular motor system. Visualization of MTs in an in vitro gliding assay has been mainly dependent on optical microscopes, limited resolution of which often render them insufficient sources of desired information. In this work, using high speed atomic force microscopy (HS-AFM), which allows imaging with higher resolution, we monitored MTs and protofilaments (PFs) of tubulins while gliding on kinesins...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28732877/enhanced-antitumor-activity-of-gemcitabine-by-polysaccharide-induced-nk-cell-activation-and-immune-cytotoxicity-reduction-in-vitro-vivo
#5
Xin Xie, Yiran Zhou, Xue Wang, Jian Guo, Jingwen Li, Hongye Fan, Jie Dou, Baiyong Shen, Changlin Zhou
The polysaccharide SEP has been reported to activate NK and T cells via TLR2/4. Here, the combination of gemcitabine (GEM) and SEP against HepG-2 was investigated. SEP apparently enhanced antitumor activity of gemcitabine against liver cancer through stimulating NKG2D and DAP10/Akt pathway to activate NK cells. The NKG2D upregulation could improve the sensitivity of NK-92 cells targeting to its ligand MICA expressed on HepG-2 cells. Meanwhile, GEM up-regulated MICA expression and attenuated soluble MICA secretion through inhibiting ADAM10 expression, which in turn enhanced the cytotoxicity of NK-92 cells against cancer cells...
October 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28732220/short-term-evaluation-of-gustatory-changes-after-surgical-removal-of-mandibular-third-molar-a-prospective-randomized-control-trial
#6
D Prabhu Shankar, P Manodh, Pradeep Devadoss, Rahul Anand, Murugan Aparna
PURPOSE: The present study was carried out to prospectively determine the incidence and severity of suprathreshold taste changes after surgical removal of mandibular third molars. MATERIALS AND METHODS: Sixty patients who required removal of impacted third molars were included in the study. Based on the Winter criteria of angulation of impacted mandibular third molars, 15 patients each with mesioangular, distoangular, horizontal, and vertical impacted third molars were selected...
June 30, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28731121/unified-total-synthesis-of-chinensiolide-b-and-8-epigrosheimin
#7
Saumen Hajra, Susit Acharyya, Abhisek Mandal, Ramkrishna Maity
An expedient synthetic approach has been developed for the unified total synthesis of (+)-chinensiolide B and (+)-8-epigrosheimin. The point of divergence was provided by the lactone aldehyde 6, in which four contiguous stereocenters were achieved by a stereocontrolled Evans syn-aldol reaction of a R-carvone derived enantiopure aldehyde and chiral N-succinyl-oxazolidinone. The lactone aldehyde 6 was synthesized in multigram quantity in three steps. Highly optimized chemo- and stereoselective reactions and functional group interconversion enabled us to assemble (+)-chinensiolide B and (+)-8-epigrosheimin from 6...
July 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28731112/carrier-free-self-assembled-pure-drug-nanorods-composed-of-10-hydroxycamptothecin-and-chlorin-e6-for-combinatorial-chemo-photodynamic-antitumor-therapy-in-vivo
#8
Yan Wen, Wei Zhang, Ningqiang Gong, Yi-Feng Wang, Hong-Bo Guo, Weisheng Guo, Paul C Wang, Xing-Jie Liang
Carrier-free nanodrugs formulated from the supramolecular self-assembly of pure drug molecules have emerged as an innovative and promising strategy for tumor therapy. We report herein a new and simple method to directly assemble a small hydrophobic anticancer drug, 10-hydroxycamptothecin (HCPT), with a photosensitizer chlorin e6 (Ce6) to form stable, discrete nanorods (NRs), which not only circumvent the extreme hydrophobicity of HCPT but also incorporate two different modalities into one delivery system for combination therapy...
July 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28730791/a-mathematical-optimization-model-for-efficient-assignment-of-inpatients-in-an-oncology-center-in-china
#9
Ming Lv, Bo Kou, Zhi-Li Zhou, Wen-Bo He
This paper addresses a problem for assignment of chemo-receiving inpatients in an oncology care center, which has not been addressed in the literature. Chemotherapy is regarded as one of the most effective treatments for cancer. In recent years, as cancer incidence increased, the number of patients admitted to a cancer treatment center has also been rising. How to balance the workload of medical service resources by planning admission of patients has become an essential problem that must be given consideration by policy- makers...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28730771/biomarkers-for-the-early-detection-of-relapses-in-metastatic-colorectal-cancers
#10
Gabriela Chereches, Otilia Barbos, Rares Buiga, Ovidiu Balacescu, Dana Iancu, Nicolae Todor, Loredana Balacescu, Nicu Miron, Nona Bejinariu, Tudor-Eliade Ciuleanu
PURPOSE: To assess prognostic/predictive value of carcinoembryonic antigen (CEA), transthyretin (TRT), αenolase (NNE), β2-microglobulin (β2-micro), B-cell activating factor (BAFF) and circulating tumor cells (CTCs) in metastatic colorectal cancer (mCRC) patients treated with chemotherapy with or without bevacizumab. METHODS: 72 histologically confirmed mCRC patients treated at Oncology Institute Cluj were included. Biomarker levels were measured through validated methods...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28729400/vessel-targeted-chemophototherapy-with-cationic-porphyrin-phospholipid-liposomes
#11
Dandan Luo, Jumin Geng, Nasi Li, Kevin A Carter, Shuai Shao, G Ekin Atilla-Gokcumen, Jonathan F Lovell
Cationic liposomes have been used for targeted drug delivery to tumor blood vessels, via mechanisms that are not fully elucidated. Doxorubicin (Dox)-loaded liposomes were prepared that incorporate a cationic lipid; 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), along with a small amount of porphyrin-phospholipid (PoP). Near infrared (NIR) light induced release of entrapped Dox via PoP-mediated DOTAP photo-oxidation. The formulation was optimized to enable extremely rapid NIR light-triggered Dox release (i...
July 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28729027/micrornas-as-multifaceted-players-in-glioblastoma-multiforme
#12
Neri Mercatelli, Silvia Galardi, Silvia Anna Ciafrè
Glioblastoma multiforme (GBM) is the most common and inevitably lethal primary brain tumor, with a median survival rate of only 15 months from diagnosis. The current standard treatment involves maximal surgical resection flanked by radiotherapy and chemotherapy with the alkylating agent temozolomide. However, even such aggressive treatment is never curative, and recurrent tumors always arise, commonly in more aggressive, chemo- and radio-resistant forms, leading to untreatable and deadly tumors. MicroRNAs, recognized major players in cancer, are deeply involved in GBM, as shown by more than a decade of studies...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28727894/enzymatic-and-chemoenzymatic-3-step-cascades-for-the-synthesis-of-stereochemically-complementary-trisubstituted-tetrahydroisoquinolines
#13
Vanessa Erdmann, Benjamin R Lichmann, Jianxiong Zhao, Robert C Simon, Wolfgang Kroutil, John M Ward, Helen C Hailes, Dörte Rother
The work described demonstrates the ability of chemo-enzymatic and enzymatic cascades to form complex stereocomplementary 1,3,4-trisubstituted tetrahydroisoquinolines (THIQ) with three chiral centres in a step-efficient and selective manner, without requiring the purification of intermediates. The cascade starting from cheap substrates (3-hydroxybenzaldehyde and pyruvate) involves a carboligation step, a subsequent transamination and finally, together with a carbonyl co-substrate, a Pictet-Spengler-reaction...
July 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28727574/flexible-ligated-ruthenium-ii-self-assemblies-sensitizes-glioma-tumor-initiating-cells-in-vitro
#14
Palani Elumalai, Neha Kaushik, Dong Hwan Kim, Hyunuk Kim, Su Jae Lee, Eun Ha Choi, Ki-Whan Chi, Nagendra Kumar Kaushik
The tumorigenic potentials of residual cancer stem-like cells within tumors represent limitations of current cancer therapies. Here, the authors describe the effects of synthesized flexible, ligated, supramolecular self-assembled chair type tetranuclear ruthenium (II) metallacycles (2-5) on glioblastoma and glioma stem like cells. These self-assemblies were observed to be selectively toxic to glioma cells and CD133-positive glioma stem like cells population. Of the self-assembled compounds tested, metallacycle 4 more efficiently induced glioma stem like cells death within a brain cancer cell population and simultaneously inhibited the formation of free-floating gliospheres by reducing the sphere size...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28727238/unified-total-synthesis-of-polyoxin-j-l-and-their-fluorinated-analogues-based-on-decarbonylative-radical-coupling-reactions
#15
Masayuki Inoue, Haruka Fujino, Masanori Nagatomo, Atmika Paudel, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu
Polyoxins J (1a) and L (1b) are important members of nucleoside antibiotics. The complex and densely functionalized dipeptide structures of 1a and 1b possess thymine and uracil nucleobases, respectively. Here we report the unified total synthesis of 1a, 1b, and their artificial analogues 1c and 1d, with trifluorothymine and fluorouracil structures. Decarbonylative radical coupling reactions between a-alkoxyacyl tellurides and a chiral glyoxylic oxime ether led to chemo- and stereoselective construction of the ribonucleoside a-amino acid structures of 1a-d without damaging the preinstalled nucleobases...
July 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28726971/an-environment-for-guideline-based-decision-support-systems-for%C3%A2-outpatients-monitoring
#16
Elisa M Zini, Giordano Lanzola, Paolo Bossi, Silvana Quaglini
OBJECTIVES: We propose an architecture for monitoring outpatients that relies on mobile technologies for acquiring data. The goal is to better control the onset of possible side effects between the scheduled visits at the clinic. METHODS: We analyze the architectural components required to ensure a high level of abstraction from data. Clinical practice guidelines were formalized with Alium, an authoring tool based on the PROforma language, using SNOMED-CT as a terminology standard...
July 19, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28725297/therapeutic-strategies-with-oral-fluoropyrimidine-anticancer-agent-s-1-against-oral-cancer
#17
REVIEW
Koji Harada, Tarannum Ferdous, Yoshiya Ueyama
Oral cancer has been recognized as a tumor with low sensitivity to anticancer agents. However, introduction of S-1, an oral cancer agent is improving treatment outcome for patients with oral cancer. In addition, S-1, as a main drug for oral cancer treatment in Japan can be easily available for outpatients. In fact, S-1 exerts high therapeutic effects with acceptable side effects. Moreover, combined chemotherapy with S-1 shows higher efficacy than S-1 alone, and combined chemo-radiotherapy with S-1 exerts remarkable therapeutic effects...
August 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28723104/chemo-and-stereoselective-crotylation-of-aldehydes-and-cyclic-aldimines-with-allylic-gem-diboronate-ester
#18
Jinyoung Park, Seoyoung Choi, Yeosan Lee, Seung Hwan Cho
We report a highly chemo- and stereoselective crotylation of aldehydes and cyclic aldimines with allylic-gem-diboronate ester as a new type of organoboron reagent. The allylic-gem-diboronate ester undergoes the crotylation with aldehydes and cyclic aldimines in excellent stereoselectivity, forming anti-5,6-disubstituted oxaborinin-2-ols or (E)-δ-boryl-anti-homoallylic amines in high efficiency. The reaction shows a wide range of substrate scope and excellent functional group tolerance. The synthetic applications of the obtained products, including stereospecific C-C, C-O, and C-Cl bond formation, are also demonstrated...
July 19, 2017: Organic Letters
https://www.readbyqxmd.com/read/28722745/co-catalyzed-highly-selective-c-sp-3-h-nitration
#19
Yao Zhou, Zhonghe Tang, Qiuling Song
A Co-catalyzed highly chemo- and regio-selective nitration of C(sp(3))-H was developed. Diverse aliphatic nitro compounds were obtained in good yields, using t-BuONO as a nitrating reagent. Specific nitration of C(sp(3))-H instead of C(sp(2))-H was achieved via a radical process rather than concerted metalation-deprotonation.
July 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28721734/enantioselective-total-synthesis-of-nigelladine-a-via-late-stage-c-h-oxidation-enabled-by-an-engineered-p450-enzyme
#20
Steven A Loskot, David K Romney, Frances H Arnold, Brian M Stoltz
An enantioselective total synthesis of the norditerpenoid alkaloid nigelladine A is described. Strategically, the synthesis relies on a late-stage C-H oxidation of an advanced intermediate. While traditional chemical methods failed to deliver the desired outcome, an engineered cytochrome P450 enzyme was employed to effect a chemo- and regioselective allylic C-H oxidation in the presence of four oxidizable positions. The enzyme variant was readily identified from a focused library of three enzymes, allowing for completion of the synthesis without the need for extensive screening...
July 24, 2017: Journal of the American Chemical Society
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