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https://www.readbyqxmd.com/read/29679750/a-fast-and-reliable-dsc-based-method-to-determine-the-monomolecular-loading-capacity-of-drugs-with-good-glass-forming-ability-in-mesoporous-silica
#1
Nele-Johanna Hempel, Katharina Brede, Niels Erik Olesen, Natalja Genina, Matthias Manne Knopp, Korbinian Löbmann
The aim of this study was to introduce a fast and reliable differential scanning calorimetry (DSC)-based method to determine the monomolecular loading capacity of drugs with good glass-forming ability in mesoporous silica (MS). The proposed method is based on a solvent-free melting/fusion of drug into the MS during a heat-cool-heat cycle in the DSC. Overloaded drug-MS systems were analyzed in the DSC at different drug ratios (50, 60, 70, 80 and 90% w/w) to quantify the excess drug in the (the fraction not adsorbed to the MS surface)...
April 18, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29679337/revisional-bariatric-surgery-for-weight-regain-and-refractory-complications-in-a-single-mbsaqip-accredited-center-what-are-we-dealing-with
#2
Jeffrey Qiu, Peter W Lundberg, T Javier Birriel, Leonardo Claros, Jill Stoltzfus, Maher El Chaar
BACKGROUND: Revisional surgery is the fastest growing area in bariatric surgery, constituting 13.6% of all procedures performed as of 2015. This reflects a rising need to treat adverse sequelae of primary bariatric procedures. Despite the increase in revisions, their safety and efficacy remain controversial. The objective of this study is to review the experience of revisional bariatric surgery in our center and the relevant literature to date. METHODS: We performed an IRB-approved review of prospectively collected data from all patients undergoing revisional bariatric surgery between 2012 and 2015...
April 20, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29678981/cohort-profile-the-italian-network-of-longitudinal-metropolitan-studies-in-limes-a-multicentre-cohort-for-socioeconomic-inequalities-in-health-monitoring
#3
Nicola Caranci, Chiara Di Girolamo, Paolo Giorgi Rossi, Teresa Spadea, Barbara Pacelli, Serena Broccoli, Paola Ballotari, Giuseppe Costa, Nicolás Zengarini, Nera Agabiti, Anna Maria Bargagli, Laura Cacciani, Cristina Canova, Laura Cestari, Annibale Biggeri, Laura Grisotto, Gianna Terni, Gianfranco Costanzo, Concetta Mirisola, Alessio Petrelli
PURPOSE: The Italian Network of Longitudinal Metropolitan Studies (IN-LiMeS) is a system of integrated data on health outcomes, demographic and socioeconomic information, and represents a powerful tool to study health inequalities. PARTICIPANTS: IN-LiMeS is a multicentre and multipurpose pool of metropolitan population cohorts enrolled in nine Italian cities: Turin, Venice, Reggio Emilia, Modena, Bologna, Florence, Leghorn, Prato and Rome. Data come from record linkage of municipal population registries, the 2001 population census, mortality registers and hospital discharge archives...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29677721/nonstoichiometric-solution-processed-batio%C3%A2-film-for-gate-insulator-applications
#4
Joyce Lau, Sangsub Kim, Hyunki Kim, Kwangjun Koo, Jaeseob Lee, Sangsoo Kim, Byoungdeog Choi
Solution processed barium titanate (BTO) was used to fabricate an Al/BaTiO3/p-Si metal-insulator-semiconductor (MIS) structure, which was used as a gate insulator. Changes in the electrical characteristics of the film were investigated as a function of the film thickness and post deposition annealing conditions. Our results showed that a thickness of 5 layers and an annealing temperature of 650 °C produced the highest electrical performance. BaxTi1-xO3 was altered at x = 0.10, 0.30, 0.50, 0.70, 0.90, and 1...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677717/a-1t-dynamic-random-access-memory-cell-based-on-gated-thyristor-with-surrounding-gate-structure-for-high-scalability
#5
Hyungjin Kim, Sihyun Kim, Hyun-Min Kim, Kitae Lee, Sangwan Kim, Byung-Gook Pak
In this study, we investigate a one-transistor (1T) dynamic random access memory (DRAM) cell based on a gated-thyristor device utilizing voltage-driven bistability to enable high-speed operations. The structural feature of the surrounding gate using a sidewall provides high scalability with regard to constructing an array architecture of the proposed devices. In addition, the operation mechanism, I-V characteristics, DRAM operations, and bias dependence are analyzed using a commercial device simulator. Unlike conventional 1T DRAM cells utilizing the floating body effect, excess carriers which are required to be stored to make two different states are not generated but injected from the n+ cathode region, giving the device high-speed operation capabilities...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677691/iodine-status-of-pregnant-women-from-a-coastal-brazilian-state-after-the-reduction-in-recommended-iodine-concentration-in-table-salt-according-to-governmental-requirements
#6
Débora Ayres Saraiva, Nathalie Anne de Oliveira E Silva de Morais, Carolina Martins Corcino, Tatiana Martins Benvenuto Louro Berbara, Annie Schtscherbyna, Mischelle Santos, Heron Botelho, Mario Vaisman, Patrícia de Fátima Dos Santos Teixeira
OBJECTIVE: To evaluate iodine status among pregnant women from a coastal state after Brazilian governmental resolution reducing iodine concentrations in table salt. Secondarily, we correlated urinary iodine concentration (UIC) with thyroid volume and hormones. METHODS: Inductively coupled plasma mass spectrometry was used to assess UIC from 629 samples of 244 first trimester pregnant women. Thyroid ultrasound, serum thyroglobulin, thyrotropin, free thyroxine, and antithyroid antibodies were measured as iodine concentrations on samples of table salt from patient's home...
February 14, 2018: Nutrition
https://www.readbyqxmd.com/read/29677592/development-of-rapid-and-simple-method-for-dna-extraction-from-cannabis-resin-based-on-the-evaluation-of-relative-pcr-amplification-ability
#7
Tadashi Yamamuro, Yuko T Iwata, Hiroki Segawa, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori, Hiroyuki Inoue
In recent years, analysis of cannabis DNA has been increasingly used in forensic drug tests. However, in the case of cannabis resin, a processed marijuana product, complicated procedures are required for the extraction of clean DNA, as the presence of various impurities inhibits PCR amplification. Therefore, in this study, we attempted to identify the factors that would allow quick and simple DNA extraction from cannabis resin with a commercially available kit. We also constructed a simple assay system for comparing relative amplification efficiencies by end-point PCR and used it to evaluate the purity of the obtained DNA solutions...
April 4, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29676857/proteomics-analysis-reveals-abnormal-electron-transport-and-excessive-oxidative-stress-cause-mitochondrial-dysfunction-in-placental-tissues-of-early-onset-preeclampsia
#8
Zhongwei Xu, Xiaohan Jin, Wei Cai, Maobin Zhou, Ping Shao, Zhen Yang, Rong Fu, Jin Cao, Yan Liu, Fang Yu, Rong Fan, Yan Zhang, Shuang Zou, Xin Zhou, Ning Yang, Xu Chen, Yuming Li
PURPOSE: Early-onset preeclampsia (EOS-PE) refers to preeclampsia that occurred before 34 gestation weeks. This study was conducted to explore the relationship between mitochondrial dysfunction and the pathogenesis of EOS-PE using proteomic strategy. EXPERIMENTAL DESIGN: To identify altering expressed mitochondrial proteins between severe EOS-PE and healthy pregnancies, enrichment of mitochondria coupled with iTRAQ-based quantitative proteomic method was performed...
April 20, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29676446/an-approach-on-the-potential-use-of-probiotics-in-the-treatment-of-skin-conditions-acne-and-atopic-dermatitis
#9
REVIEW
Vitória H M Mottin, Edna S Suyenaga
Acne and Atopic Dermatitis (AD) are chronic inflammatory skin conditions with severe impact on a patient's life. Current treatments are related to adverse effects and do not represent a definitive cure. The present paper reviews the alterations in skin microbiome, specifically in acne and AD, and aims in searching for potential treatments based on benefic microorganisms, called probiotics. The review was made through bibliographic search of the main databases (Science Direct, PubMed, Scielo, Medline) between September 2015 and June 2016...
April 20, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29676255/-perfecting-smile-esthetics-keep-it-pink
#10
Virginie Monnet-Corti, Angeline Antezack, Marion Pignoly
INTRODUCTION: Smile aesthetics is based on numerical, physical, physiological and psychological data regarding beauty, while taking into account the desires of the patient. It is determined by the shape, colour and position of the lips, teeth and gingival tissues. Periodontal examination in both the facial and labial settings supports analysis of the gingival display during natural and forced smiling, the health of the periodontium, the gingival contours, the aesthetic gingival line, and the presence of the papillae...
March 2018: L' Orthodontie Française
https://www.readbyqxmd.com/read/29675218/the-self-disproportionation-of-enantiomers-sde-a-menace-or-an-opportunity
#11
REVIEW
Jianlin Han, Osamu Kitagawa, Alicja Wzorek, Karel D Klika, Vadim A Soloshonok
Herein we report on the well-documented, yet not widely known, phenomenon of the self-disproportionation of enantiomers (SDE): the spontaneous fractionation of scalemic material into enantioenriched and -depleted fractions when any physicochemical process is applied. The SDE has implications ranging from the origins of prebiotic homochirality to unconventional enantiopurification methods, though the risks of altering the enantiomeric excess (ee) unintentionally, regrettably, remain greatly unappreciated. While recrystallization is well known as an SDE process, occurrences of the SDE in other processes are much less recognized, e...
February 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29675176/reactivity-of-highly-lewis-acidic-diborane-4-towards-pyridine-and-isocyanide-formation-of-boraalkene-pyridine-complex-and-ortho-functionalized-pyridine-derivatives
#12
Yuhei Katsuma, Hiroki Asakawa, Makoto Yamashita
The reaction of pinB-BMes2 (pin = pinacolato, Mes = 2,4,6-Me3 C6 H2 ) with Xyl-NC (Xyl = 2,6-Me2 C6 H3 ) and pyridine results in the formation of a pyridine-coordinated boraalkene that exhibits an intense color caused by an intramolecular charge-transfer interaction. In the presence of an excess of pyridine, the ortho C-H bond of pyridine was selectively functionalized to afford a quinoid compound or an isocyanide-coupled product. Based on the concentration effect, the reaction stoichiometry, and previously reported DFT calculations, a reaction mechanism that involves several rearrangement reactions was proposed...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674207/impact-of-excessive-pre-pregnancy-body-mass-index-and-abnormal-gestational-weight-gain-on-pregnancy-outcomes-in-women-with-chronic-hypertension
#13
Sara Ornaghi, Paola Algeri, Lyudmyla Todyrenchuk, Emanuela Vertemati, Patrizia Vergani
OBJECTIVES: To investigate the effects of excessive pre-pregnancy body mass index (BMI) and abnormal gestational weight gain on adverse outcomes in women with chronic hypertension (CH). STUDY DESIGN: A retrospective cohort study of CH women with singleton pregnancy delivered at our Institution in 2002-2013. Women were categorized as normal, overweight, and obese, according to their pre-pregnancy BMI. Further stratification was based on gestational weight gain (insufficient, adequate, and excessive) as defined by 2009 IOM guidelines...
April 10, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29674135/mean-hba-1c-hba-1c-variability-and-mortality-in-people-with-diabetes-aged-70-years-and-older-a-retrospective-cohort-study
#14
Angus Forbes, Trevor Murrells, Henrietta Mulnier, Alan J Sinclair
BACKGROUND: Glycaemic targets for older people have been revised in recent years because of concern that more stringent targets are associated with increased mortality. We aimed to investigate the association between glycaemic control (mean HbA1c ) and variability (variability of HbA1c over time) and mortality in older people with diabetes. METHODS: We did a 5-year retrospective cohort study using The Health Improvement Network database, which includes data from 587 UK primary care practices...
April 16, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29673351/fk506-binding-protein-10-fkbp10-regulates-lung-fibroblast-migration-via-collagen-vi-synthesis
#15
Larissa Knüppel, Katharina Heinzelmann, Michael Lindner, Rudolf Hatz, Jürgen Behr, Oliver Eickelberg, Claudia A Staab-Weijnitz
BACKGROUND: In idiopathic pulmonary fibrosis (IPF), fibroblasts gain a more migratory phenotype and excessively secrete extracellular matrix (ECM), ultimately leading to alveolar scarring and progressive dyspnea. Here, we analyzed the effects of deficiency of FK506-binding protein 10 (FKBP10), a potential IPF drug target, on primary human lung fibroblast (phLF) adhesion and migration. METHODS: Using siRNA, FKBP10 expression was inhibited in phLF in absence or presence of 2ng/ml transforming growth factor-β1 (TGF-β1) and 0...
April 19, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29673129/the-electrochemical-performance-of-silicon-nanoparticles-in-concentrated-electrolyte
#16
Zenghua Chang, Jiantao Wang, Zhaohui Wu, Min Gao, Shuaijin Wu, Shigang Lu
Silicon is a promising material for anodes in energy storage devices. However, excessive growth of solid electrolyte interphase (SEI) caused by the severe volume change during the (de)lithiation processes lead to a dramatic capacity fading. Here we report a super-concentrated electrolyte composed of Lithium bis(fluorosulfonyl)imide (LiFSI) and propylene carbonate (PC) with a molar ratio of 1 to 2 to improve the cycling performance of silicon nano particles (SiNPs). The SiNP electrode shows a remarkably improved cycling performance with an initial delithiation capacity of ca...
April 19, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29672528/saccharomyces-cerevisiae-as-a-platform-for-assessing-sphingolipid-lipid-kinase-inhibitors
#17
Yugesh Kharel, Sayeh Agah, Tao Huang, Anna J Mendelson, Oluwafunmilayo T Eletu, Peter Barkey-Bircann, James Gesualdi, Jeffrey S Smith, Webster L Santos, Kevin R Lynch
Successful medicinal chemistry campaigns to discover and optimize sphingosine kinase inhibitors require a robust assay for screening chemical libraries and for determining rank order potencies. Existing assays for these enzymes are laborious, expensive and/or low throughput. The toxicity of excessive levels of phosphorylated sphingoid bases for the budding yeast, Saccharomyces cerevisiae, affords an assay wherein inhibitors added to the culture media rescue growth in a dose-dependent fashion. Herein, we describe our adaptation of a simple, inexpensive, and high throughput assay for assessing inhibitors of sphingosine kinase types 1 and 2 as well as ceramide kinase and for testing enzymatic activity of sphingosine kinase type 2 mutants...
2018: PloS One
https://www.readbyqxmd.com/read/29672354/regional-comparison-of-cancer-incidence-mortality-and-survival-on-the-level-of-federal-states-in-germany-using-funnel-plots
#18
Karla Geiss, Martin Meyer
Population-based cancer registries allow the assessment of regional differences in cancer burden. Comparative cancer statistics are usually reported as ranked bar charts and choropleth maps, which can lead to misinterpretations of the presented figures. The aim of the present study is a regional comparison of cancer statistics in Germany on the level of federal states using funnel plots. Population-based cancer registry data on incidence, mortality, and survival on the level of federal states for the year 2011 were used...
April 18, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29671908/effects-of-fat-supplementation-on-plasma-glucose-insulin-and-fatty-acid-analysis-in-ponies-maintained-on-a-forage-based-diet
#19
T Williams, B Rude, S Liao, C Mochal-King, M Nicodemus
The objective of this study was to observe how fat incorporated into an equine forage-based diet through supplementation altered levels of plasma glucose, insulin and fatty acids. Five Shetland/Hackney cross pony mares were fed alfalfa pellet diets top dressed with commercially available vegetable oil (blend of soya bean, canola and corn oils) at 0%, 5%, 10% or 15% of diet. Ponies were randomly assigned one of four diets to start, with a 14-day adjustment period between transitioning to another one of the four diets...
April 19, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29670751/comparing-physical-activity-in-individuals-with-overweight-obesity-with-and-without-binge-eating-disorder
#20
J A Barber, V Ivezaj, R D Barnes
Objective: Differential participation in physical activity (PA) may partially explain the health discrepancies between individuals with or without binge-eating disorder (BED). Yet, little is known about the PA habits of individuals with overweight/obesity and how those patterns may differ based on BED status. PA patterns and exercise self-efficacy were examined in individuals with overweight/obesity, with and without BED. Design: Ninety-seven participants with overweight/obesity self-reported their PA via the Godin Leisure-Time Questionnaire and the Paffenbarger PA Questionnaire...
April 2018: Obesity Science & Practice
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