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https://www.readbyqxmd.com/read/28222165/stress-increases-the-risk-of-type-2-diabetes-onset-in-women-a-12-year-longitudinal-study-using-causal-modelling
#1
Melissa L Harris, Christopher Oldmeadow, Alexis Hure, Judy Luu, Deborah Loxton, John Attia
BACKGROUND: Type 2 diabetes is associated with significant morbidity and mortality. Modifiable risk factors have been found to contribute up to 60% of type 2 diabetes risk. However, type 2 diabetes continues to rise despite implementation of interventions based on traditional risk factors. There is a clear need to identify additional risk factors for chronic disease prevention. The aim of this study was to examine the relationship between perceived stress and type 2 diabetes onset, and partition the estimates into direct and indirect effects...
2017: PloS One
https://www.readbyqxmd.com/read/28220697/near-infrared-activated-upconversion-nanoprobes-for-sensitive-endogenous-zn2-detection-and-selective-on-demand-photodynamic-therapy
#2
Ping Hu, Rui Wang, Lei Zhou, Lei Chen, Qingsheng Wu, Ming-Yong Han, Ahmed Mohamed El-Toni, Dongyuan Zhao, Fan Zhang
As a light-activated non-invasive cancer treatment paradigm, photodynamic therapy (PDT) has been attracting extensive attentions because of its high treatment efficacy and low side effects. Especially, spatiotemporal control of singlet oxygen (1O2) release is highly desirable for realizing on-demand PDT, which, however, still remains a huge challenge. To address this issue, a novel switchable near infrared (NIR)-responsive upconversion nanoprobe has been firstly designed and successfully applied for controlled PDT that can be optically activated by tumor-associated disruption of labile Zn2+ (denoted as Zn2+ in the following words) homeostasis stimuli...
February 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28220317/role-of-narrative-based-medicine-in-proper-patient-assessment
#3
Giovanni Rosti
Improving patient-physician communication is an area of medicine that deserves greater attention. Narrative medicine can be considered as one tool that can aid in fostering better communication. Current medical practice is dominated by evidence-based medicine, and dictates what therapies the clinician will offer in a given circumstance, ideally supported by (evidence-based) guidelines. However, when taken alone it tends to decentralize the patient. There are many different approaches that can be used to understand the patient and what he or she is experiencing as a result of their illness...
February 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28219663/relation-of-stroke-and-major-bleeding-to-creatinine-clearance-in-patients-with-atrial-fibrillation-from-the-fushimi-af-registry
#4
Mitsuru Abe, Hisashi Ogawa, Mitsuru Ishii, Nobutoyo Masunaga, Masahiro Esato, Yeong-Hwa Chun, Hikari Tsuji, Hiromichi Wada, Koji Hasegawa, Gregory Y H Lip, Masaharu Akao
Creatinine clearance (CrCl) has been widely used to adjust the dosage of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation (AF) and exclude contraindicated patients. However, there are few available real-world data on the relation between CrCl and adverse clinical outcomes in patients with AF. Therefore, we evaluated the clinical characteristics and adverse events in Japanese patients with AF stratified by CrCl. We categorized patients in the Fushimi AF Registry, a large prospective community-based Japanese cohort of patients with AF, into 3 groups as follows: (1) CrCl <30 ml/min, (2) CrCl 30 to 49 ml/min, and (3) CrCl ≥50 ml/min...
January 25, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28219350/women-s-experiences-of-personalised-support-for-asthma-care-during-pregnancy-a-systematic-review-of-the-literature
#5
Graham R Williamson, Anita O'Connor, Elmslie-Jones Kayleigh
BACKGROUND: Asthma and pregnancy are both sources of anxiety for women. Although there has been a focus on physiological management of asthma and pregnancy, there has been little research on the impact that personalised support can have on asthma care during pregnancy. This systematic review and narrative synthesis of the literature set out to answer the question 'What are women's experiences of asthma care, its management and education, during pregnancy?' METHODS: This systematic review was carried out using accepted methodology from the York Centre for Reviews and Dissemination...
February 20, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28219050/synergism-and-mechanism-of-astragaloside-iv-combined-with-ginsenoside-rg1-against-autophagic-injury-of-pc12-cells-induced-by-oxygen-glucose-deprivation-reoxygenation
#6
Xiao-Ping Huang, Huang Ding, Xiao-Qian Yang, Jing-Xian Li, Biao Tang, Xiao-Dan Liu, Ying-Hong Tang, Chang-Qing Deng
The aim of this study was to explore the effect by which the combination of Astragaloside IV (AST IV) and Ginsenoside Rg1 (Rg1) resisted autophagic injury in PC12 cells induced by oxygen glucose deprivation/reoxygenation (OGD/R). We studied the nature of the interaction between AST IV and Rg1 that inhibited autophagy through the Isobologram method, and investigated the synergistic mechanism via the PI3K I/Akt/mTOR and PI3K III/Becline-1/Bcl-2 signaling pathways. Our results showed that, based on the 50% inhibiting concentration (IC50), AST IV combined with Rg1 at a 1:1 ratio resulted in a synergistic effect, whereas the combination of the two had an antagonistic effect on autophagy at ratios of 1:2 and 2:1...
February 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28219039/microwave-dielectric-relaxation-spectroscopy-study-of-propylene-glycol-ethanol-binary-mixtures-temperature-dependence
#7
T Vishwam, Suriya Shihab, V R K Murthy, Ha Sie Tiong, S Sreehari Sastry
Complex dielectric permittivity measurements of propylene glycol (PG) in ethanol at various mole fractions were measured by using open-ended coaxial probe technique at different temperatures in the frequency range 0.02<ν/GHz<20. The dipole moment (μ), excess dipole moment (Δμ),excess permittivity (ε(E)), excess inverse relaxation time(1/τ)(E), Bruggeman parameter (fB), excess Helmholtz energy (ΔF(E)) are determined using experimental data. From the minimum energy based geometry optimization, dipole moments of individual monomers of propylene glycol and ethanol and their binary system have been evaluated theoretically at gaseous state as well as alcoholic medium by using PCM and IEFPCM solvation models from the Hatree-Fock (HF) and Density Functional Theory (DFT-B3LYP) methods with 6-311G* and 6-311G** basis sets...
February 11, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28218719/smart-device-use-and-perceived-physical-and-psychosocial-outcomes-among-hong-kong-adolescents
#8
Stephen Wai Hang Kwok, Paul Hong Lee, Regina Lai Tong Lee
Excessive electronic screen-based activities have been found to be associated with negative outcomes. The aim of this study was to investigate the prevalences and patterns of smart device activities and the purposes and perceived outcomes related to smart device use, and the differences in patterns of smart device activities between adolescents who did and did not perceive these outcomes. The study was a cross-sectional survey of Hong Kong primary and secondary school students. Demographic characteristics, purpose and pattern of the activities, and frequencies of the outcomes were measured...
February 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28218652/steady-%C3%AE-ray-effects-on-the-performance-of-ppp-botda-and-tw-cotdr-fiber-sensing
#9
Isabelle Planes, Sylvain Girard, Aziz Boukenter, Emmanuel Marin, Sylvie Delepine-Lesoille, Claude Marcandella, Youcef Ouerdane
We investigated the evolution of the performances of Pulse Pre Pump-Brillouin Time Domain Analysis (PPP-BOTDA) and Tunable Wavelength Coherent Optical Time Domain Reflectometry (TW-COTDR) fiber-based temperature and strain sensors when the sensing optical fiber is exposed to two γ-ray irradiation conditions: (i) at room temperature and a dose rate of 370 Gy(SiO2)/h up to a total ionizing dose (TID) of 56 kGy; (ii) at room temperature and a dose rate of 25 kGy(SiO2)/h up to a TID of 10 MGy. Two main different classes of single-mode optical fibers have been tested in situ, radiation-tolerant ones: fluorine-doped or nitrogen-doped core fibers, as well as Telecom-grade germanosilicate ones...
February 17, 2017: Sensors
https://www.readbyqxmd.com/read/28218471/%C3%AE-4%C3%AE-%C3%AE-gabaa-receptors-in-dorsal-hippocampal-ca1-of-adolescent-female-rats-traffic-to-the-plasma-membrane-of-dendritic-spines-following-voluntary-exercise-and-contribute-to-protection-of-animals-from-activity-based-anorexia-through-localization-at-excitatory
#10
Chiye Aoki, Yi-Wen Chen, Tara Gunkali Chowdhury, Walter Piper
In hippocampal CA1 of adolescent female rodents, α4βδ-GABAA receptors (α4βδ-GABAA Rs) suppress excitability of pyramidal neurons through shunting inhibition at excitatory synapses. This contributes to anxiolysis of stressed animals. Socially isolated adolescent female rats with 8 days of wheel access, the last 4 days of which entail restricted food access, have been shown to exhibit excessive exercise, choosing to run instead of eat (activity-based anorexia [ABA]). Upregulation of α4βδ-GABAA Rs in the dorsal hippocampal CA1 (DH), seen among some ABA animals, correlates with suppression of excessive exercise...
February 20, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28217358/crystal-structure-of-chlorido-bis-1-2-5-6-%C3%AE-cyclo-octa-1-5-diene-iridium-i
#11
A K Fazlur Rahman, Miles Wilklow-Marnell, William W Brennessel, William D Jones
The title complex, [IrCl(C8H12)2], was synthesized directly from the reaction of IrCl3·3H2O with a large excess of cod (cod = cyclo-octa-1,5-diene) in alcoholic solvent. Large yellow needles were obtained by the slow cooling of a hot solution. Based on the positions of the chloride ligand and the mid-points of the four C=C bonds, the mol-ecule adopts a five-coordinate geometry that is midway between square pyramidal and trigonal bipyramidal. The material crystallizes in the ortho-rhom-bic space group Pbca with one mol-ecule per asymmetric unit in a general position and shows no significant inter-molecular inter-actions...
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28217266/methodology-and-early-findings-of-the-fifth-survey-of-childhood-and-adolescence-surveillance-and-prevention-of-adult-noncommunicable-disease-the-caspian-v-study
#12
Mohammad Esmaeil Motlagh, Hasan Ziaodini, Mostafa Qorbani, Majzoubeh Taheri, Tahereh Aminaei, Azam Goodarzi, Asal Ataie-Jafari, Fatemeh Rezaei, Zeinab Ahadi, Gita Shafiee, Ali Shahsavari, Ramin Heshmat, Roya Kelishadi
BACKGROUND: This paper presents the methodology and early findings of the fifth survey of a school-based surveillance program in Iran. METHODS: This nationwide study was conducted in 2015 as the fifth survey of a surveillance program entitled "Childhood and Adolescence Surveillance and PreventIon of Adult Non- communicable disease" (CASPIAN-V) study. The protocol was mainly based on the World Health Organization-Global School student Health Survey. We studied 14400 students, aged 7-18 years, and their parents living in 30 provinces in Iran...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28216995/prevalence-and-predictors-of-unhealthy-weight-gain-in-pregnancy
#13
Sara Lindberg, Cynthia Anderson, Parvathy Pillai, Aman Tandias, Brian Arndt, Lawrence Hanrahan
IMPORTANCE: Weight gain during pregnancy affects obesity risk in offspring. OBJECTIVE: To assess weight gain among UW Health prenatal patients and to identify predictors of unhealthy gestational weight gain. METHODS: Retrospective cohort study of women delivering at UW Health during 2007-2012. Data are from the UW eHealth Public Health Information Exchange (PHINEX) project. The proportion of women with excess and insufficient (ie, unhealthy) gestational weight gain was computed based on 2009 Institute of Medicine guidelines...
November 2016: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/28216700/a-retrospective-study-of-transfusion-practices-in-a-tertiary-care-institute
#14
Babita Raghuwanshi, N K Pehlajani, Mithilesh K Sinha, Swagata Tripathy
BACKGROUND AND AIMS: Excessive requests for cross matching blood which is more than the blood required for transfusion are usually based on worst case assumptions leading to overestimation of blood usage. We investigated the blood ordering pattern and transfusion practices so as to incorporate a blood ordering schedule for streamlining the use of blood in various hospital departments. METHODS: The study was conducted over a period of 19 months in a 350 bedded tertiary teaching hospital...
January 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28216695/continuous-self-sustaining-smouldering-destruction-of-simulated-faeces
#15
Ivo Fabris, Daniel Cormier, Jason I Gerhard, Tomek Bartczak, Mark Kortschot, Jose L Torero, Yu-Ling Cheng
A new approach for the rapid destruction of human waste using smouldering combustion is presented. Recently, self-sustaining smouldering combustion was shown to destroy the organic component of simulated human solid waste and dog faeces resulting in the sanitization of all pathogens using a batch process (Yermán et al., 2015). Here, a continuous smouldering process is demonstrated for the first time, allowing for a much smaller reactor size and much less energy input per mass of waste treated. The self-sustained smouldering of simulated human faeces mixed with sand is evaluated over long periods (more than 16 h) based on a single ignition...
February 15, 2017: Fuel
https://www.readbyqxmd.com/read/28215901/physical-health-medication-and-healthcare-utilization-among-70-year-old-people-with-schizophrenia-a-nationwide-danish-register-study
#16
Maria Brink, Anders Green, Anders Bo Bojesen, J Steven Lamberti, Yeates Conwell, Kjeld Andersen
OBJECTIVES: In light of the excess early mortality in schizophrenia, mainly due to physical illnesses, we investigated medical comorbidity, use of medication, and healthcare utilization among individuals with schizophrenia who survived into older ages to uncover potential factors contributing to their longevity. DESIGN: A nationwide register-based case-control study comparing 70-year-olds with and without schizophrenia. SETTING: Cases were drawn from the Danish Psychiatric Central Register...
January 9, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28215168/contributions-of-the-interaction-between-dietary-protein-and-gut-microbiota-to-intestinal-health
#17
Ning Ma, Yanan Tian, Yi Wu, Xi Ma
There is growing recognition that composition and metabolic activity of the gut microbiota can be modulated by the dietary proteins which in turn impact health. The amino acid composition and digestibility of proteins, which are influenced by its source and amount of intake, play a pivotal role in determining the microbiota. Reciprocally, it appears that the gut microbiota is also able to affect protein metabolism which give rise to the view that function between the microbiota and protein can proceed in both directions...
February 16, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28214583/remediation-of-fluoride-from-drinking-water-using-magnetic-iron-oxide-coated-hydrotalcite-chitosan-composite
#18
Kalimuthu Pandi, Soodamani Periyasamy, Natrayasamy Viswanathan
The present study was performed to examine the probability of magnetic iron oxide fabricated hydrotalcite/chitosan (Fe3O4@HTCS) composite for the removal of excess fluoride content from drinking water. The developed Fe3O4@HTCS composite not only demonstrate the good separation ability but also display an extreme enhanced defluoridation capacity (DC) when compared to other base components and composite. The DCs of Fe3O4@HTCS composite, Fe3O4@HT composite, Fe3O4, HT and CS was found to be 5032, 3041, 1050, 1030 and 52 mgF(-)/kg respectively...
February 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28213735/microalgae-based-advanced-municipal-wastewater-treatment-for-reuse-in-water-bodies
#19
REVIEW
Jing-Han Wang, Tian-Yuan Zhang, Guo-Hua Dao, Xue-Qiao Xu, Xiao-Xiong Wang, Hong -Ying Hu
Reuse of secondary municipal effluent from wastewater treatment plants in water bodies could effectively alleviate freshwater resource shortage. However, excessive nutrients must be efficiently removed to prevent eutrophication. Compared with other means of advanced wastewater treatment, microalgae-based processes display overwhelming advantages including efficient and simultaneous N and P removal, no requirement of additional chemicals, O2 generation, CO2 mitigation, and potential value-added products from harvested biomass...
February 17, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28213208/a-novel-and-sensitive-fluorescence-sensor-for-glutathione-detection-by-controlling-the-surface-passivation-degree-of-carbon-quantum-dots
#20
REVIEW
Jiahong Pan, Zengyao Zheng, Jianying Yang, Yaoyu Wu, Fushen Lu, Yaowen Chen, Wenhua Gao
A novel fluorescence sensor based on controlling the surface passivation degree of carbon quantum dots (CQDs) was developed for glutathione (GSH) detection. First, we found that the fluorescence intensity of the CQDs which was obtained by directly pyrolyzing citric acid would increased largely after the surface passivation treatment by 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). In the light of this phenomenon, we designed a simple, rapid and selective fluorescence sensor based on the surface passivated CQDs...
May 1, 2017: Talanta
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