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https://www.readbyqxmd.com/read/29456351/quality-of-sleep-and-sleep-disorders-in-patients-with-parkinsonism-a-polysomnography-based-study-from-rural-south-india
#1
Dushyanth Babu Jasti, Sarat Mallipeddi, A Apparao, B Vengamma, Satyarao Kolli, A Mohan
Objective: The objective of this study is to study the quality of sleep, sleep disorders, and polysomnographic profile in Parkinsonism patients from rural areas and to correlate polysomnographic profile with the staging of disease and with sleep questionnaire. Materials and Methods: Between May 2014 and December 2015, 168 Parkinsonism patients were prospectively screened using sleep questionnaire; Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), Parkinson Disease Sleep Score-2 (PDSS-2)...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29455616/is-the-fetal-cerebroplacental-ratio-better-that-the-estimated-fetal-weight-in-predicting-adverse-perinatal-outcomes-in-a-low-risk-cohort
#2
Christopher Flatley, Sailesh Kumar
OBJECTIVE: In high-risk pregnancies combining the cerebro-placental ratio (CPR) with the estimated fetal weight (EFW) improves the identification of vulnerable fetuses. The purpose of this study was to assess the CPR and EFW's ability to predict adverse obstetric and perinatal outcomes in a low-risk pregnancy, when measured late in gestation. METHODS: This was a retrospective study of women who birthed at Mater Mothers Hospitals, Brisbane, Australia between 2010 and 2015...
February 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29455521/self-assembly-of-binuclear-cu-ii-histidine-complex-for-absolute-configuration-and-enantiomeric-excess-determination-of-naproxen-by-tandem-mass-spectrometry
#3
Xiangying Yu, Man-Chu Chau, Wai Kit Tang, Chi-Kit Siu, Zhong-Ping Yao
Naproxen is one of the most consumed non-steroidal anti-inflammatory drugs and marketed as S-naproxen since R-naproxen is hepatotoxic. In this study, chiral recognition of naproxen has been investigated by tandem mass spectrometry (MS/MS). Among all diastereomeric complexes formed between naproxen and the examined chiral selectors, including cyclodextrins (α/β/γ-CD), modified phenylalanines (N-acetyl-phenylalanine, N-t-butoxycarbonyl-phenylalanine, N-9-fluorenylmethyloxycarbonyl-phenylalanine), amino acids (Trp, Phe, Tyr, His), glucose, tartaric acid and vancomycin, a novel binuclear metal bound diastereomeric complexes [(M(II))2 (S/R-Naproxen)(L-His)2 -3H]+ (M = Cu, Ni or Co with Cu being the best) could allow effective identification of the absolute configuration of naproxen and determination of its enantiomeric excess (ee) through MS/MS analysis...
February 17, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29454535/insurance-mandated-preoperative-diet-and-outcomes-after-bariatric-surgery
#4
Charles J Keith, Lauren E Goss, Camille D Blackledge, Richard D Stahl, Jayleen Grams
BACKGROUND: Despite a lack of demonstrated patient benefit, many insurance providers mandate a physician-supervised diet before financial coverage for bariatric surgery. OBJECTIVES: To compare weight loss between patients with versus without insurance mandating a preoperative diet. SETTING: University hospital, United States. METHODS: Retrospective study of all patients who underwent laparoscopic Roux-en-Y gastric bypass or sleeve gastrectomy over a 5-year period, stratified based on whether an insurance-mandated physician-supervised diet was required...
February 2, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29454225/low-power-lasers-on-genomic-stability
#5
Larissa Alexsandra da Silva Neto Trajano, Luiz Philippe da Silva Sergio, Ana Carolina Stumbo, Andre Luiz Mencalha, Adenilson de Souza da Fonseca
Exposure of cells to genotoxic agents causes modifications in DNA, resulting to alterations in the genome. To reduce genomic instability, cells have DNA damage responses in which DNA repair proteins remove these lesions. Excessive free radicals cause DNA damages, repaired by base excision repair and nucleotide excision repair pathways. When non-oxidative lesions occur, genomic stability is maintained through checkpoints in which the cell cycle stops and DNA repair occurs. Telomere shortening is related to the development of various diseases, such as cancer...
February 10, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29454216/non-linear-effects-of-mean-temperature-and-relative-humidity-on-dengue-incidence-in-guangzhou-china
#6
Xiaocheng Wu, Lingling Lang, Wenjun Ma, Tie Song, Min Kang, Jianfeng He, Yonghui Zhang, Liang Lu, Hualiang Lin, Li Ling
BACKGROUND: Dengue fever is an important infectious disease in Guangzhou, China; previous studies on the effects of weather factors on the incidence of dengue fever did not consider the linearity of the associations. METHODS: This study evaluated the effects of daily mean temperature, relative humidity and rainfall on the incidence of dengue fever. A generalized additive model with splines smoothing function was performed to examine the effects of daily mean, minimum and maximum temperatures, relative humidity and rainfall on incidence of dengue fever during 2006-2014...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29454114/mitochondria-targeting-mitochondrial-reactive-oxygen-species-with-mitochondriotropic-polyphenolic-based-antioxidants
#7
José Teixeira, Cláudia M Deus, Fernanda Borges, Paulo J Oliveira
Mitochondrial function and regulation of redox balance is fundamental in controlling cellular life and death pathways. Antioxidants have been used to counteract disruption of redox networks, normally associated with progressive loss of cell homeostasis and disease pathophysiology, although therapeutic success is limited mainly due to pharmacokinetic drawbacks. Attempts to improve mitochondrial function in a range of diseases spurred active drug discovery efforts. Currently, the most effective strategy to deliver drugs to mitochondria is the covalent link of lipophilic cations to the bioactive compound...
February 14, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29451416/refinement-of-in-vivo-optical-imaging-development-of-a-real-time-respiration-monitoring-system
#8
Ana L Gomes, Stuart Gilchrist, Veerle Kersemans, Marcus Westcott, Sean Smart
In vivo optical imaging enables detection and quantification of light-emitting compounds from the whole body in small animals such as the mouse, but it typically requires the use of anaesthetics for subject immobilisation due to long exposure times. Excessively deep anaesthesia can result in unacceptably compromised physiology, whilst excessively light anaesthesia can result in animals waking up. Here we report a respiratory monitoring setup for an in vivo bioluminescence and fluorescence imaging device which simultaneously allows real-time adaptive control of anaesthesia depth in multiple animals to (i) potentially increase the consistency between animals, (ii) ensure animals are maintained within minimally intrusive, adequate anaesthetic plane and (iii) provide a valuable refinement strategy for a common challenge within animal-based research...
January 1, 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29450966/highly-uniform-resistive-switching-properties-of-solution-processed-silver-embedded-gelatin-thin-film
#9
Yu-Chi Chang, Cheng-Jung Lee, Li-Wen Wang, Yeong-Her Wang
The silver-embedded gelatin (AgG) thin film produced by the solution method of metal salts dissolved in gelatin is presented. Its simple fabrication method ensures the uniform distribution of Ag dots. Memory devices based on AgG exhibit good device performance, such as the ON/OFF ratio in excess of 10 5 and the coefficient of variation in less of 50%. To further investigate the position of filament formation and the role of each element, current sensing atomic force microscopy (CSAFM) analysis as well as elemental line profiles across the two different conditions in the LRS and HRS are analyzed...
February 16, 2018: Small
https://www.readbyqxmd.com/read/29450773/influence-of-mn-2-ions-on-the-corrosion-mechanism-of-lead-based-anodes-and-the-generation-of-heavy-metal-anode-slime-in-zinc-sulfate-electrolyte
#10
Chenmu Zhang, Ning Duan, Linhua Jiang, Fuyuan Xu, Jin Luo
The influence of Mn 2+ ions on the generation of heavy metal anode slime during zinc electrolysis industry was extensively investigated using several electrochemical methods, electron microscope technologies, and particle size analysis. Results showed that the Mn 2+ could obviously promote oxygen evolution reaction (OER) and thereby weaken oxidation efficiency of Mn 2+ (η MnO2 ) and dissolution of Pb 2+ . The significant improvement in kinetic parameters for OER was found in electrolytes of 1 and 3 g/L Mn 2+ , but became unstable as the Mn 2+ concentration increased to 10 g/L...
February 15, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29449766/directional-preference-of-the-wrist-a-preliminary-investigation
#11
Joseph R Maccio, Lindsay Carlton, Sarah Fink, Chanel Ninan, Chandree Van Vranken, Garret Biese, Colin McGowan, Joseph G Maccio, Julia Tranquillo
Background: Directional preference is a phenomenon that occurs in musculoskeletal disorders. It is associated with improved symptomatic and functional outcomes. Research has shown a 90% increase in the identification of directional preference in the peripheral joints between 2006 and 2012. There is currently no research analyzing if predictive variables exist for establishing directional preference. Case Description: This report presents 19 consecutive patients with wrist pain...
December 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29449263/patterns-of-methadone-maintenance-treatment-provision-in-ontario-policy-success-or-pendulum-excess
#12
Paul Kurdyak, Binu Jacob, Juveria Zaheer, Benedikt Fischer
OBJECTIVE: To describe recent trends and patterns in methadone maintenance treatment (MMT) practice regionally and over time in the province of Ontario. DESIGN: Population-based descriptive study using health administrative data between September 1, 2011, and December 31, 2014. SETTING: Ontario. PARTICIPANTS: All active MMT-prescribing physicians and patients receiving MMT in the study period. MAIN OUTCOME MEASURES: Characteristics of MMT-prescribing physicians, including age, sex, specialty type, practice region, and practice volume; characteristics of patients receiving MMT, including age, sex, neighbourhood income, and region of residence...
February 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29449116/chronic-impacts-of-oxytetracycline-on-mesophilic-anaerobic-digestion-of-excess-sludge-inhibition-of-hydrolytic-acidification-and-enrichment-of-antibiotic-resistome
#13
Zhe Tian, Yu Zhang, Min Yang
We evaluated the chronic impact of oxytetracycline (OTC) on performance and antibiotic resistance development during the mesophilic anaerobic digestion (AD) of antibiotic-containing biomass. Mesophilic AD was conducted in a completely stirred tank reactor by constantly feeding municipal excess sludge spiked with increasing concentrations of OTC (0-1000 mg L -1 ) under a solid retention time of 20 days over a period of 265 days. Results showed that methane generation of mesophilic AD was inhibited when the OTC concentration in digested sludge was increased to around 18,000 mg kg -1 (OTC dose, 1000 mg L -1 ), due to the inhibition of fermenting and acidogenic bacteria...
February 12, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29449049/extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-national-study-of-antimicrobial-treatment-for-pediatric-urinary-tract-infection
#14
M Lagree, S Bontemps, R Dessein, F Angoulvant, F Madhi, A Martinot, R Cohen, F Dubos
OBJECTIVE: To evaluate clinical practices for ESBL-producing urinary tract infection (UTI) in France. METHODS: We performed an observational, retrospective, cross-sectional, hospital-based study in 22 pediatric departments of university or secondary care hospitals. We collected data of the last five patients presenting with ESBL-producing UTI in 2012 and the physicians' therapeutic approach to two case vignettes of acute non-septic ESBL-producing pyelonephritis (7-month-old girl) and cystitis (30-month-old girl)...
February 12, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29448922/a-randomised-control-crossover-trial-of-a-theory-based-intervention-to-improve-sun-safe-and-healthy-behaviours-in-construction-workers-study-protocol
#15
Amanda Nioi, Charlotte Wendelboe-Nelson, Sue Cowan, Hilary Cowie, Shahzad Rashid, Peter Ritchie, Mark Cherrie, Terry C Lansdown, John W Cherrie
BACKGROUND: Exposure to sunlight can have both positive and negative health impacts. Excessive exposure to ultra-violet (UV) radiation from the sun can cause skin cancer, however insufficient exposure to sunlight has a detrimental effect on production of Vitamin D. In the construction industry there are onsite proactive behaviours for safety, but sun-safety remains a low priority. There is limited research on understanding the barriers to adopting sun-safe behaviours and the association this may have with Vitamin D production...
February 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29448522/effect-of-graphene-tio%C3%A2-composite-layer-on-the-performance-of-dye-sensitized-solar-cells
#16
Liguo Wei, Shishan Chen, Yulin Yang, Yongli Dong, Weina Song, Ruiqin Fan
Graphene has attracted a lot of attention because of its unique mechanical, thermal, electrical and optical properties. In this study, a double layered structured photoanode consisting of a graphene/TiO2 composite layer and a TiO2 nanoparticles (P25) underlayer was developed. The photoelectric properties of as-prepared double layer structured photoanode were studied with comparison of the anatase TiO2 photoanode. Graphene was prepared by reduction of graphene oxide (GO) under a hydrothermal conditions and graphenen/TiO2 composite semiconductor materials were prepared by mixing graphene into TiO2 paste...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448246/effect-of-mst1-on-endometriosis-apoptosis-and-migration-role-of-drp1-related-mitochondrial-fission-and-parkin-required-mitophagy
#17
Qingdong Zhao, Mingxia Ye, Wen Yang, Min Wang, Mingxia Li, Chenglei Gu, Luyang Zhao, Zhe Zhang, Weidong Han, Wensheng Fan, Yuanguang Meng
BACKGROUND/AIMS: Mitochondrial homeostasis is implicated in the development and progression of endometriosis through poorly defined mechanisms. Mst1 is the major growth suppressor related to cancer migration, apoptosis and proliferation. However, whether Mst1 is involved in endometriosis apoptosis and migration via regulating the mitochondrial function remains to be elucidated. METHODS: Expression of Mst1 in endometriosis was examined via western blots. Cellular apoptosis was detected via MTT and TUNEL assay...
February 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29448213/preparation-of-dumbbell-manganese-dioxide-gelatin-composites-and-their-application-in-the-removal-of-lead-and-cadmium-ions
#18
Xiu Wang, Kai Huang, Ying Chen, Jiafa Liu, Shan Chen, Jianlei Cao, Surong Mei, Yikai Zhou, Tao Jing
The nano-sized sorbents restrict their practical application in flow-through system due to excessive pressure. In this study, dumbbell MnO 2 /gelatin composites were synthesized based on the protein-assisted synthesis technology. Then they were immobilized on the amino-modified polymethyl methacrylate (PMMA) plate. SEM, TEM, XRD, XPS and FT-IR were employed to study the surface properties and the adsorption mechanism of MnO 2 /gelatin composites. Adsorption experiments for Pb(II) and Cd(II) ions were performed to study the adsorption isotherms, kinetics, and thermodynamics as well as the influencing factors...
February 9, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29448153/projecting-future-climate-change-impacts-on-heat-related-mortality-in-large-urban-areas-in-china
#19
Ying Li, Ting Ren, Patrick L Kinney, Andrew Joyner, Wei Zhang
Global climate change is anticipated to raise overall temperatures and has the potential to increase future mortality attributable to heat. Urban areas are particularly vulnerable to heat because of high concentrations of susceptible people. As the world's largest developing country, China has experienced noticeable changes in climate, partially evidenced by frequent occurrence of extreme heat in urban areas, which could expose millions of residents to summer heat stress that may result in increased health risk, including mortality...
February 12, 2018: Environmental Research
https://www.readbyqxmd.com/read/29447263/insurance-status-and-cancer-treatment-mediate-the-association-between-race-ethnicity-and-cervical-cancer-survival
#20
Sarah C Markt, Tianyu Tang, Angel M Cronin, Ingrid T Katz, Brooke E Howitt, Neil S Horowitz, Larissa J Lee, Alexi A Wright
Cervical cancer outcomes remain poor among disadvantaged populations, including ethnic minorities, low-income, and underinsured women. The aim of this study was to evaluate the mechanisms that underlie the observed association between race/ethnicity and cervical cancer survival. We identified 13,698 women, ages 21 to 64 years, diagnosed with stages I-III primary cervical cancer between 2007-2013 in Surveillance, Epidemiology, and End Results (SEER). Multivariable Cox proportional hazards regression models evaluated associations between race/ethnicity (Non-Hispanic White, Non-Hispanic Black, Hispanic, Other) and cervical cancer-specific mortality...
2018: PloS One
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