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JOURNAL ARTICLE
Ramanarayana Boyapati, Jyothirmayee Peeta, Ravindranath Dhulipalla, Lakshmikanth Kolaparthy, Chaitanya Adurty, Ramya Naga Shivani Cheruvu
BACKGROUND: Chemical plaque control with mouthwashes as an adjunct to mechanical plaque control with a toothbrush and dental floss has been considered an effective method for controlling gingivitis. The anti-inflammatory effects of chemical plaque control benefit the oral tissues by reducing inflammation and bleeding. OBJECTIVES: The aim of the present study was to evaluate and compare the clinical efficacy of probiotic, Aloe vera, povidine-iodine, and chlorhexidine (CHX) mouthwashes in treating gingivitis patients by assessing changes in their clinical parameters...
2024: Dental and Medical Problems
#2
JOURNAL ARTICLE
Oruç Numan Gökçe, Kenan Çetin, Şükrü Taş, Sevil Alkan, Uğur Dinç
OBJECTIVE: We aimed to determine the scolicidal effect of hypochlorous acid and its efficiency at different concentrations. MATERIALS AND METHODS: We tested the effectiveness of hypochlorous acid in-vitro on sterile gauze at different concentrations in test tubes. In addition, we compared its effectiveness with the scolicidal activity of other agents, povidone-iodine 10% and chlorhexidine-gluconate 0.04%. RESULTS: Hypochlorous acid was 100% effective in 5 minutes at 1/1 (200 ppm/mL), 1/10 (20 ppm/ml), and 1/100 (2 ppm/mL) concentrations and in 10 minutes at 1/1000 (0...
June 2023: Infect Dis Clin Microbiol
#3
REVIEW
Nathan Sim, Hannah Lee, Neerav Goyal, John D Cramer
OBJECTIVE: To review current literature and guidelines on antiseptic surgical site preparations for preventing surgical site infections with consideration of contraindications specific to head and neck surgery. DATA SOURCES: PubMed/MEDLINE, clinicaltrials.gov, accessdata.fda.gov, Manufacturer websites. REVIEW METHODS: A scoping review on the literature and clinical studies comparing the efficacy of different surgical site preparations. Studies were included if they were a randomized controlled trial (RCT) comparing at least two commonly used and available antiseptic preparations...
April 3, 2024: American Journal of Otolaryngology
#4
JOURNAL ARTICLE
Bernhard Olzowy, Sarina Müller, Natascha Antonia Cidlinsky, Daniela Guderian
For preoperative skin antisepsis, alcohol-containing iodine solutions and octenidine are suitable. For wound antisepsis, polyhexanide and hypochlorous acid (HOCL) are also available, but only PVP-iodine and HOCL can be applied to cartilage. Chlorhexidine should only be used as mouth- and bodywash for Staphylococcus aureus (MRSA) decolonization. For the many other throat antiseptics, evidence of clinical efficacy is lacking. For decolonization of the nares, polyhexanide and octenidine are available as nasal gels, but these are inferior to mupirocin for MRSA decolonization...
April 9, 2024: HNO
#5
JOURNAL ARTICLE
Yash Sewpaul, Richard Huynh, Brook Leung, Harry Alcock, Sandeep Krishan Nayar, Mustafa S Rashid
BACKGROUND: Cutibacterium acnes ( C acnes ) is a commensal skin bacterium, primarily found in sebaceous glands and hair follicles, with a high prevalence in the shoulder region. It is the most common pathogenic organism in prosthetic joint infections after shoulder arthroplasty. Because of its low virulence, its diagnosis remains difficult. PURPOSE: To evaluate the relative effects of topical preparations in reducing C acnes in shoulder surgery. STUDY DESIGN: Meta-analysis; Level of evidence, 1...
April 9, 2024: American Journal of Sports Medicine
#6
REVIEW
A Dhanya Mackeen, Maranda V Sullivan, Vincenzo Berghella
The preoperative preparation for cesarean delivery is a multistep approach for which protocols should exist at each hospital system. These protocols should be guided by the findings of this review. The interventions reviewed and recommendations made for this review have a common goal of decreasing maternal and neonatal morbidity and mortality related to cesarean delivery (CD). The preoperative time period starts prior to the patient's arrival to the hospital and ends immediately prior to skin incision. Skin cleansing in addition to CDC recommendations of showering with either soap or an antiseptic solution at least the night prior to a procedure has not been shown to further decrease rates of infection...
April 2, 2024: American journal of obstetrics & gynecology MFM
#7
JOURNAL ARTICLE
Rubin Hadad, Anne Hedengran, Alex Barnils, Goran Petrovski, Barbara Cvenkel, Tor P Utheim, Darlene A Dartt, Steffen Heegaard, Miriam Kolko
PURPOSE: To compare the effect of the ocular antiseptic treatments 0.05% chlorhexidine, 5% povidone-iodine (PI) and 5% betadine on cell viability and mucin secretion of primary cultured human goblet cells (GCs). METHOD: GC viability was analysed using lactate dehydrogenase (LDH) and tetrazolium dye (MTT) colorimetric assays. Expression of mucin was visualised by immunohistochemical MUC5AC staining. RESULTS: PI and betadine significantly reduced GC survival compared to the control (mean cell survival 23 ± 6% and 23 ± 7%, respectively, p < 0...
March 30, 2024: Acta Ophthalmologica
#8
JOURNAL ARTICLE
Lisa Saidel-Odes, Rivka Yosipovich, Vadim Benkovich, Tai Friesem, Ronit Nativ, Orli Sagi, Orly Shimoni, Abraham Borer
BACKGROUND: Surgical site infection (SSI) is a frequent health care-associated infection. We aimed to reduce SSI risk after joint arthroplasty and spine surgery by reducing Staphylococcus aureus colonization burden with presurgery intranasal povidone-iodine (PVP-I) application in conjunction with skin antisepsis ("the intervention"). METHODS: Retrospective case-control study; postintervention cohort versus a historical cohort. Adults who underwent joint arthroplasty or spine surgery during February 2018 through October 2021 ("post-intervention cohort") included...
March 22, 2024: American Journal of Infection Control
#9
JOURNAL ARTICLE
Debra Dunn, Kara Yannotti, Andrea Centrella-Nigro, Stacy Correa, Denise O'Dea, Sandra Wiley
Many surgeons request use of 10% povidone-iodine (PI) for vaginal antisepsis; however, when PI is contraindicated, some surgeons request use of chlorhexidine gluconate (CHG) instead. The purpose of this randomized controlled trial was to determine any significant differences in self-reported symptoms associated with vaginal antisepsis with either 10% PI scrub or 4% CHG with 4% isopropyl alcohol. The control group comprised 62 participants who underwent vaginal antisepsis with the PI product, and the intervention group comprised 58 participants who underwent vaginal antisepsis with the CHG product...
April 2024: AORN Journal
#10
JOURNAL ARTICLE
Kirk Aj Stephenson, Andrew Merkur, Andrew Kirker, David Albiani, Kaivon Pakzad-Vaezi
OBJECTIVE: To assess the rate of post-intravitreal injection endophthalmitis between 2 asepsis groups: aqueous chlorhexidine 0.1% and povidone-iodine 5%. DESIGN: Retrospective, observational cohort study. PARTICIPANTS: Patients with infectious endophthalmitis post intravitreal injection (n = 58) at a single centre from July 2009 to July 2022. METHODS: Retrospective chart review of all patients receiving intravitreal injections (216 593 injections) at a single centre over 14 years...
February 19, 2024: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
#11
JOURNAL ARTICLE
Simon Deeming, Xenia Dolja-Gore, Jon Gani, Rosemary Carroll, Natalie Lott, John Attia, Penny Reeves, Stephen R Smith
BACKGROUND: The application of antiseptic skin agents prior to incision minimizes the rate of surgical site infection. Despite their ubiquity, the optimal skin preparation agent remains uncertain. A retrospective economic analysis was conducted to complement the results from the NEWSkin Prep trial which prospectively compared three preparation agents. METHODS: A cost and cost-effectiveness analysis was performed from a healthcare service perspective to compare chlorhexidine with 70% ethanol, and aqueous povidone-iodine, against povidone-iodine with 70% ethanol...
January 3, 2024: BJS Open
#12
RANDOMIZED CONTROLLED TRIAL
SManwar Ali, Leesa Misra, Manash Ranjan Sahoo, Vikram V S, Ashoka Mahapatra, Bikram Rout, Swastik Sourav Mishra
INTRODUCTION: Many studies have demonstrated significant antibiotic resistance by commonly isolated organisms. This is an eye-opener for the clinicians, who prescribe antibiotics day in and out. This situation shifts our attention towards the usage of antiseptic measures, which can at times play an important role in preventing and treating various infections. METHOD: This is a double-blinded randomized controlled study that compares the bundle approach to the conventional approach for the prevention of surgical site infections in patients of peritonitis undergoing midline laparotomy in emergency...
February 15, 2024: Langenbeck's Archives of Surgery
#13
JOURNAL ARTICLE
Nuha Alghamdi, Bhaskar Das, Santosh I Hugar, Priyanka Sarangi, Garima Garg, Savadamoorthi Kamatchi Subramani
BACKGROUND AND AIM: A sessile multicellular organism that is immersed in a self-produced matrix of extracellular polymeric substances and has its cells firmly attached to a surface is referred to as a microbial biofilm. When it comes to pulp and periradicular pathosis, biofilms are crucial. To reduce the number of microorganisms in the root canal and assist in treating periapical pathosis, endodontic therapy must include decontamination of the system of tooth root canals through biomechanical preparation and irrigation of the root canal...
January 2024: Curēus
#14
JOURNAL ARTICLE
Ahmed Shawky Ammar, Hossam Elnoamany, Hany Elkholy
BACKGROUND: In pediatrics, shunt infection is considered the most common complication of ventriculoperitoneal (VP) shunts insertion and the main cause of shunt failure. Careful surgical technique and hygienic skin preparations are highly important for prevention of shunt infections. Our objective was to assess the significance of using preoperative chlorhexidine/alcohol as a skin antiseptic in reducing the infection rate in pediatric VP shunts surgery. PATIENTS AND METHODS: A retrospective, case control study conducted on 80 pediatric patients with active hydrocephalus...
February 9, 2024: Journal of Neurological Surgery. Part A, Central European Neurosurgery
#15
JOURNAL ARTICLE
Adegbolahan Fakoya, Adefemi Afolabi, Omobolaji Ayandipo, Olufunmilola Makanjuola, Olalekan Adepoju, Oluwasanmi Ajagbe, Oludolapo O Afuwape
BACKGROUND: Surgical site infection (SSI) persists as a global challenge, accounting for 20%-25% of all healthcare-associated infections. The SSI rate has been reported to range from 2.5% to 41.9%. Skin preparation with acceptable antiseptic preparations has a high recommendation from the Centers for Disease Control as an SSI preventive measure. AIM: The aim was to compare the efficacy of 10% povidone-iodine in 70% isopropyl alcohol with 2% chlorhexidine in 70% isopropyl alcohol in preventing SSI...
January 2024: Curēus
#16
EDITORIAL
Tom Nolan
No abstract text is available yet for this article.
February 8, 2024: BMJ: British Medical Journal
#17
RANDOMIZED CONTROLLED TRIAL
Sheila Sprague, Gerard Slobogean, Jeffrey L Wells, Nathan N O'Hara, Lehana Thabane, C Daniel Mullins, Anthony D Harris, Amber Wood, Darius Viskontas, Kelly L Apostle, Robert V O'Toole, Manjari Joshi, Herman Johal, Jamal Al-Asiri, Robert A Hymes, Greg E Gaski, Holly T Pilson, Eben A Carroll, Sharon Babcock, Jason J Halvorson, Nicholas M Romeo, Christopher A Matson, Thomas F Higgins, Lucas S Marchand, Patrick F Bergin, John Morellato, Robert E Van Demark, G David Potter, I Leah Gitajn, Gerard Chang, Kevin D Phelps, Laurence B Kempton, Madhav Karunakar, Todd Jaeblon, Haley K Demyanovich, Christopher M Domes, Gabrielle R Kuhn, Rachel M Reilly, Mark J Gage, Michael J Weaver, Arvind G von Keudell, Marilyn Heng, Michael F McTague, Ahmad Alnasser, Samir Mehta, Derek J Donegan, Roman M Natoli, Jan Szatkowski, Alesha N Scott, Steven F Shannon, Kyle J Jeray, Stephanie L Tanner, Meir T Marmor, Amir Matityahu, Justin T Fowler, Sarah N Pierrie, Michael J Beltran, Cameron G Thomson, Carol A Lin, Charles N Moon, John A Scolaro, Arya Amirhekmat, Jordan Leonard, David Pogorzelski, Sofia Bzovsky, Diane Heels-Ansdell, Olivia P Szasz, Jodi L Gallant, Gregory J Della Rocca, Robert D Zura, Joan N Hebden, Joseph T Patterson, Christopher Lee, Lyndsay M O'Hara, Debra Marvel, Jana E Palmer, Jeff Friedrich, Jean-Claude G D'Alleyrand, Jessica C Rivera, Franca Mossuto, Gregory M Schrank, Gordon Guyatt, P J Devereaux, Mohit Bhandari
BACKGROUND: Studies evaluating surgical-site infection have had conflicting results with respect to the use of alcohol solutions containing iodine povacrylex or chlorhexidine gluconate as skin antisepsis before surgery to repair a fractured limb (i.e., an extremity fracture). METHODS: In a cluster-randomized, crossover trial at 25 hospitals in the United States and Canada, we randomly assigned hospitals to use a solution of 0.7% iodine povacrylex in 74% isopropyl alcohol (iodine group) or 2% chlorhexidine gluconate in 70% isopropyl alcohol (chlorhexidine group) as preoperative antisepsis for surgical procedures to repair extremity fractures...
February 1, 2024: New England Journal of Medicine
#18
JOURNAL ARTICLE
José Pimenta, Carla Dias, Mário Cotovio, Maria José Saavedra
Considering the increasing antibiotics resistance, there has been a propensity to replace them with antiseptics when it comes to wound management and treatment. Nevertheless, in recent years, there have been reports regarding resistance to antiseptics by some bacterial strains. There is also concern about the environmental impact of these substances. The aim of this study was to compare the antimicrobial efficacy of antiseptics and eucalyptus essential oils on bacterial strains from horse's wounds. We used twelve Escherichia coli , eight Staphylococcus aureus , two Staphylococcus pseudintermedius , one Staphylococcus vitulinus and one Staphylococcus saprophyticus strains from equine wounds...
December 26, 2023: Veterinary Sciences
#19
JOURNAL ARTICLE
Goutham Vijayakumar, Gidean A Sundaram, Santhosh P Kumar, Vinod K Krishna, Murugesan Krishnan
Introduction Oral and maxillofacial surgeons frequently perform the removal of impacted mandibular third molars. The success of this surgical intervention depends on meticulous surgical technique and the use of appropriate irrigants to minimize complications in the postoperative period. Aim The aim of this study was to evaluate the efficacy of four different irrigation solutions (povidone-iodine, metronidazole, chlorhexidine gluconate (CHX), and normal saline) on postoperative sequelae like pain, trismus, swelling, and alveolar osteitis following surgical extraction of the impacted mandibular third molars...
December 2023: Curēus
#20
JOURNAL ARTICLE
Koshi Ota, Daisuke Nishioka, Emi Hamada, Kanna Ota, Yuriko Shibata, Akira Takasu
BACKGROUND: We aimed to determine whether puncture sites for blood sampling and topical disinfectants are associated with rates of contaminated blood cultures in the emergency department (ED) of a single institution. METHODS: This single-center, ambidirectional cohort study of 548 consecutive patients ≥20 years of age was performed in the ED of a university hospital in Japan over a 13-month period. Pairs of blood samples were collected for aerobic and anaerobic cultures from patients in the ED...
January 2024: Journal of General and Family Medicine
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