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chlorhexidine iodine

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https://www.readbyqxmd.com/read/29317910/impact-of-choice-of-skin-preparation-solution-in-cardiac-surgery-on-rate-of-surgical-site-infection-a-propensity-score-matched-analysis
#1
Shahzad G Raja, Melissa Rochon, Clair Mullins, Carlos Morais, Antonios Kourliouros, Ellie Wishart, Anthony De Souza, Sunil Bhudia
Background: Antiseptic skin preparations containing chlorhexidine gluconate and povidone iodine are routinely used to reduce the risk of surgical site infection (SSI). This study assesses the efficacy of two alcohol-based solutions, 2% chlorhexidine-alcohol and 10% povidone iodine-alcohol, on the incidence of cardiac SSI. Methods: A total of 738 consecutive patients undergoing cardiac surgery had skin preparation with 2% chlorhexidine gluconate in 70% isopropanol (ChloraPrep, BD Ltd, UK) were propensity matched to 738 patients with skin prepared with 10% povidone-iodine in 30% industrial methylated spirit (Videne Alcoholic Tincture, Ecolab Ltd, UK)...
January 2018: Journal of Infection Prevention
https://www.readbyqxmd.com/read/29316457/topical-chlorhexidine-povidone-iodine-and-erythromycin-in-the-repair-of-traumatic-ulcers-on-the-rat-tongue-clinical-histological-and-microbiological-evaluation
#2
Dieni da Silveira Teixeira, Maria Antonia Zancanaro de Figueiredo, Karen Cherubini, Maria Claudia Rosa Garcia, Sílvia Dias de Oliveira, Fernanda Gonçalves Salum
OBJECTIVE: This study investigated the effect of topical application of 0.12% chlorhexidine, 10% povidone-iodine and 50% erythromycin on the optimization of healing process of traumatic ulcers made on ventral tongue of rats. DESIGN: Forty-Eight Wistar rats were randomly divided into four groups: control, chlorhexidine (Chx), povidone-iodine (PvI) and erythromycin (Er). An ulcer of 5 mm in diameter was made on the ventral tongue of the animals. After 24 h, a microbiological sample was taken and daily application of the substances started...
January 4, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29313865/evaluation-of-emdogain%C3%A2-antimicrobial-effectiveness-against-biofilms-containing-the-keystone-pathogen-porphyromonas-gingivalis
#3
Jérôme Lasserre, Selena Toma, Ana-Maria Dos Santos-Gonçalvez, Julian Leprince, Gaëtane Leloup, Michel Brecx
This study aimed to evaluate the antimicrobial activity of Emdogain® (EMD) against biofilms containing the periopathogen Porphyromonas gingivalis. A brain-Heart infusion broth inoculated with S. gordonii and P. gingivalis was perfused (7-d, anaerobiosis) through a closed circuit containing two Robbins devices as to form biofilms. The latter were then treated for 2 min with various antimicrobials (Chlorhexidine (CHX) 0.2%, Povidone iodine (PVI) 5%, PVI 10%, essential oils (EO), EO Zero™ or EMD)(n=8) and cell densities were calculated and compared...
January 9, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29290346/predictive-factors-of-catheter-related-bloodstream-infection-in-patients-receiving-home-parenteral-nutrition
#4
Orawan Pichitchaipitak, Sineenuch Ckumdee, Siriluk Apivanich, Darunee Chotiprasitsakul, Prapimporn Chattranukulchai Shantavasinkul
OBJECTIVES: The aim of this study was to determine the incidence and predictive factors of catheter-related bloodstream infections (CRBSIs) acquired through a central venous catheter for delivery of home parenteral nutrition (HPN) therapy among a patient population in Thailand. METHODS: This retrospective review was conducted with adult patients with intestinal failure who received HPN from October 2002 to April 2014, at Ramathibodi Home Parenteral and Enteral Nutrition Referral Center in Bangkok...
February 2018: Nutrition
https://www.readbyqxmd.com/read/29244973/cooperativity-between-antibiotics-and-antiseptics-testing-the-bactericidal-effect
#5
S Jenull, H Laggner, I Hassl, B Velimirov, M Huettinger, N Zemann
OBJECTIVE: Treatment with antibiotics together with local application of antiseptics is common in wound care. We investigated the effectiveness of an antiseptic in two variations: octenidine (Oct) and octenidine+ (Oct+ with isotonic glucose addition). METHOD: Using the agar diffusion test with cultures of pathogenic Staphylococcus aureus and the non-pathogenic Bordetella petrii, we compared the effectiveness of octenidine to the classical antiseptics beta-isodona (povidone-iodine; PI), chlorhexidine (Chl) and taurolin (Tau) alone, and in combination with various common antibiotics to uncover cooperativity between antiseptics and antibiotics...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29240873/preliminary-results-of-the-use-of-a-stabilized-hypochlorous-acid-solution-in-the-management-of-ralstonia-pickettii-biofilm-on-silicone-breast-implants
#6
C Tod Brindle, Steve Porter, Kiran Bijlani, Sridhar Arumugam, Rowena Matias, Ron Najafi, Jack Fisher
Background: Ralstonia Pickettii biofilms are associated with pocket infections following breast implant surgeries. Biofilm protects bacteria most topically applied antimicrobial irrigations. Objectives: To evaluate the effectiveness of four antimicrobial solutions on the planktonic form and established biofilm of Ralstonia Pickettii grown on 3 different types of silicone breast implants. Methods: Time kill assays at clinical concentrations of chlorhexidine gluconate, povidone iodine, triple-antibiotic solution, and a 0...
December 12, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29240639/absorbable-antibiotic-beads-prophylaxis-in-immediate-breast-reconstruction
#7
Denise M Kenna, Busayo Irojah, Kimber Lee Mudge, Kendra Eveler
BACKGROUND: Breast reconstruction with tissue expander is the most common mode of reconstruction following mastectomy. Infection necessitating tissue expander removal is a significant complication leading to patient distress as well as increased health care costs. METHODS: Over 3 years, 127 breast reconstructions with tissue expanders were performed by a single surgeon. Fifty-nine of these reconstructions were performed using a standardized protocol in which patients washed with chlorhexidine several days prior to surgery and received intravenous antibiotics preoperatively...
December 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29204500/intraoperative-chlorhexidine-irrigation-to-prevent-infection-in-total-hip-and-knee-arthroplasty
#8
Nicholas B Frisch, Omar M Kadri, Troy Tenbrunsel, Abraham Abdul-Hak, Mossub Qatu, Jason J Davis
Background: Surgical site irrigation during total hip (THA) and total knee (TKA) arthroplasty is a routine practice among orthopaedic surgeons to prevent periprosthetic joint infection. The purpose of this study was to evaluate the effect of chlorhexidine gluconate (CHG) irrigation on infection rates following THA and TKA. Methods: Arthroplasties performed before September 2014 served as controls. THA performed before September 2014 (N = 253) underwent intraoperative irrigation with 0...
December 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/29190159/performance-of-bio-occlusive-dressing-as-barrier-protection-from-presurgical-chlorhexidine-skin-preparation
#9
Frank Brodie, Gregory Bever, David G Hwang
Purpose/Aim of the study: Chlorhexdine has been shown to provide excellent and cost-effective presurgical antisepsis. However, standard presurgical concentrations of chlorhexidine (2-4%) are known to cause ocular injury, even in cases in which a bio-occlusive dressing (Tegaderm™) was applied beforehand to the closed eye. MATERIALS AND METHODS: Three experiments were conducted to assess the barrier performance of Tegaderm™ to chlorhexidine skin prep in vitro and on non-ocular skin...
November 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29171793/preoperative-skin-antisepsis-with-chlorhexidine-gluconate-versus-povidone-iodine-a-prospective-analysis-of-6959-consecutive-spinal-surgery-patients
#10
George M Ghobrial, Michael Y Wang, Barth A Green, Howard B Levene, Glen Manzano, Steven Vanni, Robert M Starke, George Jimsheleishvili, Kenneth M Crandall, Marina Dididze, Allan D Levi
OBJECTIVE The aim of this study was to determine the efficacy of 2 common preoperative surgical skin antiseptic agents, ChloraPrep and Betadine, in the reduction of postoperative surgical site infection (SSI) in spinal surgery procedures. METHODS Two preoperative surgical skin antiseptic agents-ChloraPrep (2% chlorhexidine gluconate and 70% isopropyl alcohol) and Betadine (7.5% povidone-iodine solution)-were prospectively compared across 2 consecutive time periods for all consecutive adult neurosurgical spine patients...
November 24, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29165561/evaluation-of-short-exposure-times-of-antimicrobial-wound-solutions-against-microbial-biofilms-from-in-vitro-to-in-vivo
#11
K Johani, M Malone, S O Jensen, H G Dickson, I B Gosbell, H Hu, Q Yang, G Schultz, K Vickery
Objectives: Test the performance of topical antimicrobial wound solutions against microbial biofilms using in vitro, ex vivo and in vivo model systems at clinically relevant exposure times. Methods: Topical antimicrobial wound solutions were tested under three different conditions: (in vitro) 4% w/v Melaleuca oil, polyhexamethylene biguanide, chlorhexidine, povidone iodine and hypochlorous acid were tested at short duration exposure times for 15 min against 3 day mature biofilms of Staphylococcus aureus and Pseudomonas aeruginosa; (ex vivo) hypochlorous acid was tested in a porcine skin explant model with 12 cycles of 10 min exposure, over 24 h, against 3 day mature P...
November 18, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29140837/disruption-of-biofilms-and-neutralization-of-bacteria-using-hypochlorous-acid-solution-an-in-vivo-and-in-vitro-evaluation
#12
Anna Day, Abdulnaser Alkhalil, Bonnie C Carney, Hilary N Hoffman, Lauren T Moffatt, Jeffrey W Shupp
OBJECTIVES: The aims of this study were to assess the effectiveness of a hypochlorous acid-based wound cleanser (Vashe Wound Solution [VWS], SteadMed Medical, Fort Worth, Texas) in disrupting methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa biofilms relative to other cleansers using an in vitro collagen biofilm model and to evaluate cleansers' cytotoxicity. The bioburden reduction of venous stasis wounds by VWS and another cleanser was evaluated. METHODS: Plates coated with collagen films incubated with active bacteria cultures to yield biofilm mimics were treated with VWS, 1% and 10% povidone-iodine (PI), 0...
December 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29137898/antiseptics-commonly-used-in-total-joint-arthroplasty-interact-and-may-form-toxic-products
#13
Sean T Campbell, Lawrence H Goodnough, Chase G Bennett, Nicholas J Giori
BACKGROUND: Multiple antiseptics have been described for use in total joint arthroplasty infection, and the use of multiple antiseptic solutions during a single operation has been described. Our clinical experience is that chlorhexidine (CHX) and Dakin's solution (NaOCl) interact and form a precipitate. The purpose of this study is to determine whether this reaction could be replicated in a laboratory setting, and to determine if other commonly used antiseptics also visibly react when mixed...
November 11, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29107630/new-ways-of-surgical-hand-preparation-with-chlorhexidine-soap-or-povidone-iodine-in-order-to-increase-their-immediate-and-residual-effects-as-a-safe-alternative-to-use-of-alcohol-solutions
#14
Rafael Herruzo, Maria Jose Vizcaino, Rubén Yela
INTRODUCTION: Surgical use of 4% chlorhexidine soap (CHX-4) and 10% iodine povidone (PVP-I-10) do not meet the standards defined by EN12791. We investigated whether it would be possible to use these antiseptics to increase their immediate and residual effects? METHODS: During 3 consecutive weeks, n-propanol, standard CHX-4 or PVP-I-10 were tested in two experimental groups of volunteers. The new method of applying the antiseptic substances consisted of, before donning gloves, applying (after the standard hand rub and rinse of the CHX-4 or PVP-I-10) an aqueous solution based on 5% chlorhexidine or PVP-I-10, respectively, with no further rinsing of the hands...
October 28, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29104379/effect-of-dentin-disinfection-with-2-chlorhexidine-gluconate-and-0-3-iodine-on-dentin-bond-strength-an-in-vitro-study
#15
Nelamakanahalli K Suma, Kukkalli K Shashibhushan, V V Subba Reddy
Objective: Cavity preparation is a surgical procedure that attempts to remove all infected dentin.(1) Bacteria left beneath the filling material is greatest threat to the pulp. To reduce the potential for residual caries development and sensitivity, an antibacterial solution with the ability to disinfect the prepared tooth surface would be of help.(2) So this study was conducted to evaluate and compare the effect of dentin disinfection with 2% chlorhexidine gluconate (Consepsis) and 0...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29093281/the-effects-of-essential-oil-povidone-iodine-and-chlorhexidine-mouthwash-on-salivary-nitrate-nitrite-and-nitrate-reducing-bacteria
#16
Takahiro Mitsui, Ryô Harasawa
Dietary nitrate is reduced to nitrite and nitric oxide by microbial flora, and this activity is beneficial to vascular health. It has been reported that this bacterial process is inhibited by chlorhexidine mouthwash, although the effects of other products are largely unknown. This study examined the effects of several treatments on salivary nitrate/nitrite and nitrate-reducing bacteria. Twelve university staff and students performed mouth-washing with water (control), essential oil, 0.35% povidone-iodine, or 0...
October 31, 2017: Journal of Oral Science
https://www.readbyqxmd.com/read/29084111/effect-of-irrigation-time-of-antiseptic-solutions-on-bone-cell-viability-and-growth-factor-release
#17
Kosaku Sawada, Ken Nakahara, Maiko Haga-Tsujimura, Masako Fujioka-Kobayashi, Tateyuki Iizuka, Richard J Miron
Antiseptic solutions are commonly utilized to treat local infection in the oral and maxillofacial region. However, surrounding vital bone is also exposed to antiseptic agents during irrigation and may have a potential negative impact on bone survival. The aim of the present study was therefore to investigate the effect of rinsing time with various antiseptic solutions on bone cell viability, as well as their subsequent release of growth factors important for bone regeneration. The bone samples collected from porcine mandible were rinsed in the following commonly utilized antiseptic solutions; povidone-iodine (0...
October 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29074717/2-chlorhexidine-70-isopropyl-alcohol-versus-10-povidone-iodine-for-insertion-site-cleaning-before-central-line-insertion-in-preterm-infants-a-randomised-trial
#18
Emily A Kieran, Anne O'Sullivan, Jan Miletin, Anne R Twomey, Susan J Knowles, Colm Patrick Finbarr O'Donnell
OBJECTIVE: To determine whether 2% chlorhexidine gluconate-70% isopropyl alcohol (CHX-IA) is superior to 10% aqueous povidone-iodine (PI) in preventing catheter-related blood stream infection (CR-BSI) when used to clean insertion sites before placing central venous catheters (CVCs) in preterm infants. DESIGN: Randomised controlled trial. SETTING: Two neonatal intensive care units (NICUs). PATIENTS: Infants <31 weeks' gestation who had a CVC inserted...
October 26, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29061748/in-vitro-evaluation-of-povidone-iodine-and-chlorhexidine-against-outbreak-and-non-outbreak-strains-of-mycobacterium-abscessus-using-standard-quantitative-suspension-and-carrier-testing
#19
Aristine Cheng, Hsin-Yun Sun, Yi-Tzu Tsai, Un-In Wu, Yu-Chung Chuang, Jann-Tay Wang, Wang-Huei Sheng, Po-Ren Hsueh, Yee-Chun Chen, Shan-Chwen Chang
BackgroundPovidone-iodine (PI) and chlorhexidine (CHX) are widely used antiseptics active against conventional Staphylococcus aureus, Enterobacteriaceae, Candida species and viruses but their efficacy against Mycobacterium abscessus remain unproven.MethodsWe determined the in vitro potency of alcoholic PI and CHX against M. abscessus subspecies abscessus (ATCC 19977), M. abscessus subspecies bolletii (BCRC 16915), our outbreak strain of M. abscessus subspecies massiliense (TPE 101) in reference to Staphylococcus aureus (ATCC 29213) by standard quantitative suspension and carrier methods (EN 14563)...
October 23, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29038632/evaluation-of-post-surgical-bacteremia-with-use-of-povidone-iodine-and-chlorhexidine-during-mandibular-third-molar-surgery
#20
Anil Managutti, Sunita A Managutti, Jigar Patel, Nagaraj Y Puthanakar
BACKGROUND: Microorganisms may invade the blood stream by oral routes through surgical procedures like extractions, fractured teeth and periodontal pockets. The incidence of bacteremia is 70-80 % following tooth extraction, sub gingival scaling and intra ligament injection. AIMS AND OBJECTIVES: Aim of study was to evaluate and compare the efficacy of two topical antimicrobial agents for the prevention of post-surgical bacteremia during mandibular third molar surgery...
December 2017: Journal of Maxillofacial and Oral Surgery
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