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chlorhexidine iodine

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https://www.readbyqxmd.com/read/28193164/proposed-phase-2-step-2-in-vitro-test-on-basis-of-en-14561-for-standardised-testing-of-the-wound-antiseptics-pvp-iodine-chlorhexidine-digluconate-polihexanide-and-octenidine-dihydrochloride
#1
Kathrin Schedler, Ojan Assadian, Uta Brautferger, Gerald Müller, Torsten Koburger, Simon Classen, Axel Kramer
BACKGROUND: Currently, there is no agreed standard for exploring the antimicrobial activity of wound antiseptics in a phase 2/ step 2 test protocol. In the present study, a standardised in-vitro test is proposed, which allows to test potential antiseptics in a more realistically simulation of conditions found in wounds as in a suspension test. Furthermore, factors potentially influencing test results such as type of materials used as test carrier or various compositions of organic soil challenge were investigated in detail...
February 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28183858/comparison-of-topical-chlorhexidine-and-mupirocin-for-the-prevention-of-exit-site-infection-in-incident-peritoneal-dialysis-patients
#2
Htay Htay, David W Johnson, Sin Yan Wu, Elizabeth L Oei, Marjorie Wai Yin Foo, Jason C Choo
♦ Objective: Prevention of exit-site infection (ESI) is of paramount importance to peritoneal dialysis (PD) patients. The aim of this study was to evaluate the effectiveness of chlorhexidine in the prevention of ESI in incident PD patients compared with mupirocin. ♦ Methods: This retrospective, pre-test/post-test observational study included all incident PD patients at Singapore General Hospital from 2012 to 2015. Patients received daily topical exit-site application of either mupirocin (2012 - 2013) or chlorhexidine (2014 - 2015) in addition to routine exit-site cleaning with 10% povidone-iodine...
February 9, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28124850/a-quality-improvement-approach-to-reducing-the-caesarean-section-surgical-site-infection-rate-in-a-regional-hospital
#3
M O'Hanlon, C McKenna, E Carton, D Diviney, M R Costello, L O'Sullivan, J Fitzsimons, L Toland, G Dornikova, R Curran, C McCann, L O'Sullivan, T Doherty, C Crowley, S O'Coigligh
Surgical site infection (SSI) rates are used extensively by hospitals as a basis for quality improvement. A 30-day post-discharge SSI programme for Caesarean section operations has been implemented in Our Lady of Lourdes Hospital since 2011. It has been shown that skin antisepsis and antibiotic prophylaxis are key factors in the prevention of SSI. Using quality improvement methodology, an infection prevention bundle was introduced to address these two factors. Skin antisepsis was changed from povidone-iodine to chlorhexidine-alcohol...
September 9, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/28040299/reimplantation-of-a-large-extruded-segment-of-bone-in-an-open-fracture
#4
REVIEW
Ahmadreza Afshar
Replacing an extruded segment of bone in an open fracture imposes a challenging decision concerning the best and safest patient management. There are numerous advantages to restoring the patient's own extruded bone segment to its original location, particularly when the bone segment is of structural importance. However, reimplantation of contaminated and avascular extruded bone segments can potentially result in serious infection or nonunion. There is no conclusive evidence regarding the best decontamination protocol for the safest use of the recovered bone segment as an autologous graft...
February 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27995837/antiseptic-effect-of-conventional-povidone-iodine-scrub-chlorhexidine-scrub-and-waterless-hand-rub-in-a-surgical-room-a-randomized-controlled-trial
#5
Jui-Chen Tsai, Yen-Kuang Lin, Yen-Jung Huang, El-Wui Loh, Hsiao-Yun Wen, Chia-Hui Wang, Yin-Tai Tsai, Wen-Shyang Hsieh, Ka-Wai Tam
OBJECTIVE Effective perioperative hand antisepsis is crucial for the safety of patients and medical staff in surgical rooms. The antimicrobial effectiveness of different antiseptic methods, including conventional hand scrubs and waterless hand rubs, has not been well evaluated. DESIGN, SETTING, AND PARTICIPANTS A randomized controlled trial was conducted to investigate the effectiveness of the 3 antiseptic methods among surgical staff of Taipei Medical University-Shuang Ho Hospital. For each method used, a group of 80 participants was enrolled...
December 20, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27986361/systematic-review-and-meta-analysis-of-the-effectiveness-of-antiseptic-agents-for-meatal-cleaning-in-the-prevention-of-catheter-associated-urinary-tract-infections
#6
REVIEW
O Fasugba, J Koerner, B G Mitchell, A Gardner
BACKGROUND: Catheter-associated urinary tract infections (CAUTIs) are among the most common healthcare-associated infections. Antiseptic cleaning of the meatal area before and during catheter use may reduce the risk of CAUTIs. AIM: To undertake a systematic review of the literature and meta-analysis of studies investigating the effectiveness of antiseptic cleaning before urinary catheter insertion and during catheter use for prevention of CAUTIs. METHODS: Electronic databases were searched to identify randomized controlled trials...
November 4, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27879993/randomized-clinical-trial-of-preoperative-skin-antisepsis-with-chlorhexidine-gluconate-or-povidone-iodine
#7
H M Park, S-S Han, E C Lee, S D Lee, H M Yoon, B W Eom, S H Kim, K W Ryu, S-J Park, Y W Kim, B Park
BACKGROUND: Skin antiseptic agents are used to prevent surgical-site infection (SSI); few trials have reported the superiority of any specific agent in clean-contaminated abdominal surgery. This RCT was designed to compare the effectiveness of chlorhexidine gluconate and povidone-iodine. METHODS: Consecutive patients who underwent clean-contaminated upper gastrointestinal or hepatobiliary-pancreatic open surgery between 2011 and 2014 were assigned randomly to either chlorhexidine gluconate or povidone-iodine...
January 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/27865488/the-influence-of-3-different-navel-dips-on-calf-health-growth-performance-and-umbilical-infection-assessed-by-clinical-and-ultrasonographic-examination
#8
M Wieland, S Mann, C L Guard, D V Nydam
The objectives were to investigate the effect of 3 navel dips on (1) umbilical infection, (2) health events (pneumonia, diarrhea, and arthritis), and (3) average daily gain (ADG) in newborn dairy calves. A secondary aim was to compare the agreement of standardized ultrasonographic examination with clinical examination for the diagnosis of umbilical infection. In a randomized block design, newborn calves were assigned by birth order to 3 treatment groups: Navel Guard (NG; SCG-Solutions Inc., McDonough, GA), 7% iodine tincture (SI), and 2% chlorhexidine gluconate (CH)...
January 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27844305/cytocompatibility-testing-of-cyclodextrin-functionalized-antimicrobial-textiles-a-comprehensive-approach
#9
Kirsten Reddersen, Susanne Finger, Michael Zieger, Cornelia Wiegand, Hans-Jürgen Buschmann, Peter Elsner, Uta-Christina Hipler
Functionalized textiles can be used in wound management to reduce the microbial burden in the wound area, to prevent wound infections, and to avoid cross-contamination between patients. In the present study, a comprehensive in vitro approach to enable the assessment of antibacterial activity of functionalized textiles and cytotoxicity of cyclodextrin (CD)-complexes with chlorhexidine diacetate (CHX), iodine (IOD), and polihexanide (PHMB) is suggested to evaluate their properties for supporting optimal conditions for wound healing...
December 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27824737/povidone-iodine-0-05-chlorhexidine-gluconate-or-water-for-periurethral-cleaning-before-indwelling-urinary-catheterization-in-a-pediatric-intensive-care-a-randomized-controlled-trial
#10
Duygu Sönmez Düzkaya, Gülzade Uysal, Gülçin Bozkurt, Tülay Yakut, Agop Çitak
PURPOSE: The aim of this study was to evaluate the efficacy of periurethral cleaning with 10% povidone-iodine, 0.05% chlorhexidine gluconate, or sterile water in preventing catheter-associated urinary tract infections (CAUTIs) prior to indwelling urinary catheter insertion in a pediatric intensive care unit. A secondary aim was to identify pathogens resulting in CAUTIs in this group. DESIGN: Randomized controlled trial. SUBJECTS AND SETTING: One hundred twenty-two patients cared for in a pediatric intensive care unit of a university hospital between September 2012 and December 2013 participated in the study...
January 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/27778318/oral-hygiene-care-for-critically-ill-patients-to-prevent-ventilator-associated-pneumonia
#11
REVIEW
Fang Hua, Huixu Xie, Helen V Worthington, Susan Furness, Qi Zhang, Chunjie Li
BACKGROUND: Ventilator-associated pneumonia (VAP) is defined as pneumonia developing in people who have received mechanical ventilation for at least 48 hours. VAP is a potentially serious complication in these patients who are already critically ill. Oral hygiene care (OHC), using either a mouthrinse, gel, toothbrush, or combination, together with aspiration of secretions, may reduce the risk of VAP in these patients. OBJECTIVES: To assess the effects of oral hygiene care on incidence of ventilator-associated pneumonia in critically ill patients receiving mechanical ventilation in hospital intensive care units (ICUs)...
October 25, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27762078/phenotypic-resistance-to-disinfectants-and-antibiotics-in-methicillin-resistant-staphylococcus-aureus-strains-isolated-from-pigs
#12
E Espigares, E Moreno Roldan, M Espigares, R Abreu, B Castro, A L Dib, Á Arias
The aim of this research was to study the phenotypic resistances to disinfectants and antibiotics in strains of methicillin-resistant Staphylococcus aureus (MRSA) obtained from Canary black pigs. Analyses were performed on 54 strains of MRSA, isolated in Canary black pigs from the province of Tenerife (Spain); all of them carried the mecA gene. The strains were isolated by means of nasal swab samples of healthy pigs, collected under veterinarian supervision. Bactericidal activity of antiseptics and disinfectants was tested by means of the dilution-neutralization method...
October 20, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27720552/aqueous-chlorhexidine-for-intravitreal-injection-antisepsis-a-case-series-and-review-of-the-literature
#13
Rohan Merani, Zachary E McPherson, Alan P Luckie, Jagjit S Gilhotra, Jim Runciman, Shane Durkin, James Muecke, Mark Donaldson, Albert Aralar, Anupam Rao, Peter E Davies
PURPOSE: To determine the incidence of endophthalmitis in a large clinical series using aqueous chlorhexidine for antisepsis before intravitreal injection and to review the ophthalmic literature regarding chlorhexidine efficacy and safety. DESIGN: Multicenter retrospective case series. PARTICIPANTS: All patients receiving intravitreal injections from 7 retinal specialists. METHODS: An audit of intravitreal injections performed by retinal specialists who exclusively used aqueous chlorhexidine 0...
December 2016: Ophthalmology
https://www.readbyqxmd.com/read/27720156/identification-of-factors-influencing-teat-dip-efficacy-trial-results-by-meta-analysis
#14
B D Enger, R R White, S C Nickerson, L K Fox
Two meta-analyses were conducted using data from peer-reviewed natural exposure (NE) and experimental challenge (EC) teat dip efficacy trials to identify factors influencing the new intramammary infection (IMI) rate. A NE data set containing 16 studies and an EC data set containing 21 studies were created. New IMI rate was calculated based on the percentage of new quarter infections per month (PNQI/mo) for each observation, in both data sets, and used as the dependent variable for model derivation. A linear, mixed-effects model with a random study effect, weighted by number of quarters eligible for infection, was derived for each data set...
December 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27707940/chlorhexidine-versus-tincture-of-iodine-for-reduction-of-blood-culture-contamination-rates-a-prospective-randomized-crossover-study
#15
Elizabeth Story-Roller, Melvin P Weinstein
Blood cultures (BCs) are the standard method for diagnosis of bloodstream infections (BSIs). However, the average BC contamination rate (CR) in U.S. hospitals is 2.9%, potentially resulting in unnecessary antibiotic use and excessive therapy costs. Several studies have compared various skin antisepsis agents without a clear consensus as to which agent is most effective in reducing contamination. A prospective, randomized crossover study directly comparing blood culture contamination rates using chlorhexidine versus iodine tincture for skin antisepsis was performed at Robert Wood Johnson University Hospital (RWJUH)...
December 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27647026/corneal-injury-from-presurgical-chlorhexidine-skin-preparation
#16
Gregory J Bever, Frank L Brodie, David G Hwang
BACKGROUND: Chlorhexidine skin preparation has been shown to provide highly effective antimicrobial presurgical skin cleansing. However, there is a significant risk of ocular toxicity when it is used in periocular areas. CASE DESCRIPTION: We describe 2 cases of significant corneal damage resulting from 4% chlorhexidine gluconate preoperative skin cleanser, despite the use of protective occlusive dressing over the eyes. Because of the potential for severe corneal toxicity resulting from use of chlorhexidine, alternative agents such as 10% povidone-iodine should be considered for skin preparation near periocular areas whenever possible...
September 16, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27630954/comparative-evaluation-of-two-different-ultrasonic-liquid-coolants-on-dental-aerosols
#17
Rashmi Jawade, Vishnudas Bhandari, Gauri Ugale, Snehal Taru, Surbhi Khaparde, Arun Kulkarni, Mukesh Ardale, Shraddha Marde
INTRODUCTION: Dentists are more prone for developing infectious diseases especially related to respiratory system. The ultrasonic scaler which is a major source of dental aerosol production is most frequently used contrivance in a dental set up. AIM: The aim of this study was to evaluate the effect of povidone iodine and chlorhexidine gluconate as an ultrasonic liquid coolant on aerosols in comparison with distilled water. The objectives of this study were to compare the potency of povidone iodine and chlorhexidine gluconate on reducing dental aerosols and quantitative assessment of microbial content of dental aerosols at right, left and behind the dental chair...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27509308/the-effect-on-clinical-parameters-of-periodontal-inflammation-following-non-surgical-periodontal-therapy-with-ultrasonics-and-chemotherapeutic-cooling-solutions-a-systematic-review
#18
Marjolein Van der Sluijs, Eveline Van der Sluijs, Fridus Van der Weijden, Dagmar Else Slot
AIM: To establish the added effect of a chemotherapeutic cooling solution in an ultrasonic device on clinical parameters of periodontal inflammation following non-surgical periodontal therapy. METHODS: The MEDLINE-PubMed, Cochrane-CENTRAL, and the EMBASE databases were searched. Probing pocket depth (PPD) and clinical attachment level (CAL) and their changes were selected as outcome variables. Subgroup analyses were performed according to the following active ingredients: essential oils (EO), povidone-iodine (PVP), and chlorhexidine (CHX)...
August 10, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27508334/surgical-hand-antisepsis-and-surgical-site-infections
#19
Brad S Oriel, Kamal M F Itani
BACKGROUND: Surgical site infections (SSI) remain a significant problem to both the patients and the healthcare system. Value care and standardized quality measures continue to promote improvement in surgical asepsis, but certain debates remain unresolved in the field of surgical hand antisepsis. METHODS: Review of relevant accounts and literature. RESULTS: Controversy has existed regarding the U.S. Food and Drug Administration (FDA)'s 1994 Tentative Final Monograph (TFM), which defined how surgical hand antisepsis products are assessed...
December 2016: Surgical Infections
https://www.readbyqxmd.com/read/27472980/impact-of-antiseptics-on-chlamydia-trachomatis-growth
#20
L Párducz, I Eszik, G Wagner, K Burián, V Endrész, D P Virok
UNLABELLED: Bacterial vaginosis is a frequent dysbiosis, where the normal lactobacillus-dominated flora is replaced by an anaerob/aerob polymicrobial flora. Bacterial vaginosis increases the risk of acquiring sexually transmitted infections (STI) including the most frequent Chlamydia trachomatis infections. Intravaginal antiseptics are part of the bacterial vaginosis treatment, and ideally they should also inhibit the bacterial vaginosis-related STI. Therefore, we tested the antichlamydial activity of four antiseptics: iodine aqueous solution, povidone-iodine, chlorhexidine and borax...
October 2016: Letters in Applied Microbiology
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