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chlorhexidine iodine

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https://www.readbyqxmd.com/read/29140837/disruption-of-biofilms-and-neutralization-of-bacteria-using-hypochlorous-acid-solution-an-in-vivo-and-in-vitro-evaluation
#1
Anna Day, Abdulnaser Alkhalil, Bonnie C Carney, Hilary N Hoffman, Lauren T Moffatt, Jeffrey W Shupp
OBJECTIVES: The aims of this study were to assess the effectiveness of a hypochlorous acid-based wound cleanser (Vashe Wound Solution [VWS], SteadMed Medical, Fort Worth, Texas) in disrupting methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa biofilms relative to other cleansers using an in vitro collagen biofilm model and to evaluate cleansers' cytotoxicity. The bioburden reduction of venous stasis wounds by VWS and another cleanser was evaluated. METHODS: Plates coated with collagen films incubated with active bacteria cultures to yield biofilm mimics were treated with VWS, 1% and 10% povidone-iodine (PI), 0...
December 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29137898/antiseptics-commonly-used-in-total-joint-arthroplasty-interact-and-may-form-toxic-products
#2
Sean T Campbell, Lawrence H Goodnough, Chase G Bennett, Nicholas J Giori
BACKGROUND: Multiple antiseptics have been described for use in total joint arthroplasty infection, and the use of multiple antiseptic solutions during a single operation has been described. Our clinical experience is that chlorhexidine (CHX) and Dakin's solution (NaOCl) interact and form a precipitate. The purpose of this study is to determine whether this reaction could be replicated in a laboratory setting, and to determine if other commonly used antiseptics also visibly react when mixed...
November 11, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29107630/new-ways-of-surgical-hand-preparation-with-chlorhexidine-soap-or-povidone-iodine-in-order-to-increase-their-immediate-and-residual-effects-as-a-safe-alternative-to-use-of-alcohol-solutions
#3
Rafael Herruzo, Maria Jose Vizcaino, Rubén Yela
INTRODUCTION: Surgical use of 4% chlorhexidine soap (CHX-4) and 10% iodine povidone (PVP-I-10) do not meet the standards defined by EN12791. We investigated whether it would be possible to use these antiseptics to increase their immediate and residual effects? METHODS: During 3 consecutive weeks, n-propanol, standard CHX-4 or PVP-I-10 were tested in two experimental groups of volunteers. The new method of applying the antiseptic substances consisted of, before donning gloves, applying (after the standard hand rub and rinse of the CHX-4 or PVP-I-10) an aqueous solution based on 5% chlorhexidine or PVP-I-10, respectively, with no further rinsing of the hands...
October 28, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29104379/effect-of-dentin-disinfection-with-2-chlorhexidine-gluconate-and-0-3-iodine-on-dentin-bond-strength-an-in-vitro-study
#4
Nelamakanahalli K Suma, Kukkalli K Shashibhushan, V V Subba Reddy
Objective: Cavity preparation is a surgical procedure that attempts to remove all infected dentin.(1) Bacteria left beneath the filling material is greatest threat to the pulp. To reduce the potential for residual caries development and sensitivity, an antibacterial solution with the ability to disinfect the prepared tooth surface would be of help.(2) So this study was conducted to evaluate and compare the effect of dentin disinfection with 2% chlorhexidine gluconate (Consepsis) and 0...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29093281/the-effects-of-essential-oil-povidone-iodine-and-chlorhexidine-mouthwash-on-salivary-nitrate-nitrite-and-nitrate-reducing-bacteria
#5
Takahiro Mitsui, Ryô Harasawa
Dietary nitrate is reduced to nitrite and nitric oxide by microbial flora, and this activity is beneficial to vascular health. It has been reported that this bacterial process is inhibited by chlorhexidine mouthwash, although the effects of other products are largely unknown. This study examined the effects of several treatments on salivary nitrate/nitrite and nitrate-reducing bacteria. Twelve university staff and students performed mouth-washing with water (control), essential oil, 0.35% povidone-iodine, or 0...
October 31, 2017: Journal of Oral Science
https://www.readbyqxmd.com/read/29084111/effect-of-irrigation-time-of-antiseptic-solutions-on-bone-cell-viability-and-growth-factor-release
#6
Kosaku Sawada, Ken Nakahara, Maiko Haga-Tsujimura, Masako Fujioka-Kobayashi, Tateyuki Iizuka, Richard J Miron
Antiseptic solutions are commonly utilized to treat local infection in the oral and maxillofacial region. However, surrounding vital bone is also exposed to antiseptic agents during irrigation and may have a potential negative impact on bone survival. The aim of the present study was therefore to investigate the effect of rinsing time with various antiseptic solutions on bone cell viability, as well as their subsequent release of growth factors important for bone regeneration. The bone samples collected from porcine mandible were rinsed in the following commonly utilized antiseptic solutions; povidone-iodine (0...
October 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29074717/2-chlorhexidine-70-isopropyl-alcohol-versus-10-povidone-iodine-for-insertion-site-cleaning-before-central-line-insertion-in-preterm-infants-a-randomised-trial
#7
Emily A Kieran, Anne O'Sullivan, Jan Miletin, Anne R Twomey, Susan J Knowles, Colm Patrick Finbarr O'Donnell
OBJECTIVE: To determine whether 2% chlorhexidine gluconate-70% isopropyl alcohol (CHX-IA) is superior to 10% aqueous povidone-iodine (PI) in preventing catheter-related blood stream infection (CR-BSI) when used to clean insertion sites before placing central venous catheters (CVCs) in preterm infants. DESIGN: Randomised controlled trial. SETTING: Two neonatal intensive care units (NICUs). PATIENTS: Infants <31 weeks' gestation who had a CVC inserted...
October 26, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29061748/in-vitro-evaluation-of-povidone-iodine-and-chlorhexidine-against-outbreak-and-non-outbreak-strains-of-mycobacterium-abscessus-using-standard-quantitative-suspension-and-carrier-testing
#8
Aristine Cheng, Hsin-Yun Sun, Yi-Tzu Tsai, Un-In Wu, Yu-Chung Chuang, Jann-Tay Wang, Wang-Huei Sheng, Po-Ren Hsueh, Yee-Chun Chen, Shan-Chwen Chang
BackgroundPovidone-iodine (PI) and chlorhexidine (CHX) are widely used antiseptics active against conventional Staphylococcus aureus, Enterobacteriaceae, Candida species and viruses but their efficacy against Mycobacterium abscessus remain unproven.MethodsWe determined the in vitro potency of alcoholic PI and CHX against M. abscessus subspecies abscessus (ATCC 19977), M. abscessus subspecies bolletii (BCRC 16915), our outbreak strain of M. abscessus subspecies massiliense (TPE 101) in reference to Staphylococcus aureus (ATCC 29213) by standard quantitative suspension and carrier methods (EN 14563)...
October 23, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29038632/evaluation-of-post-surgical-bacteremia-with-use-of-povidone-iodine-and-chlorhexidine-during-mandibular-third-molar-surgery
#9
Anil Managutti, Sunita A Managutti, Jigar Patel, Nagaraj Y Puthanakar
BACKGROUND: Microorganisms may invade the blood stream by oral routes through surgical procedures like extractions, fractured teeth and periodontal pockets. The incidence of bacteremia is 70-80 % following tooth extraction, sub gingival scaling and intra ligament injection. AIMS AND OBJECTIVES: Aim of study was to evaluate and compare the efficacy of two topical antimicrobial agents for the prevention of post-surgical bacteremia during mandibular third molar surgery...
December 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29019097/efficacy-of-conventional-and-liposomal-povidone-iodine-in-infected-mesh-skin-grafts-an-exploratory-study
#10
Peter M Vogt, Joerg Hauser, Stefan Mueller, Bjoern Bosse, Michael Hopp
INTRODUCTION: Infection is a major threat to wound healing and a leading cause of graft loss in patients undergoing meshed skin grafts (MSGs). Therefore, topical antisepsis is important in the overall treatment scheme. METHODS: An exploratory satellite group of 14 patients with infected MSGs were enrolled as part of a prospective, randomized, controlled, parallel-group, open-label, pilot Phase II study that investigated the efficacy and tolerability of 3% liposomal povidone-iodine hydrogel (PVP-ILH, Repithel(®); RepiGel(®)) versus chlorhexidine gauze in non-infected MSGs...
October 10, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28969846/prospective-single-center-observational-study-of-the-allergenic-potential-of-mercromina-film-and-other-common-antiseptics-in-patients-with-contact-dermatitis
#11
S Baltà Cruz, N Moreno Ribera, M T Estrach Panella
INTRODUCTION: Although Mercromina Film and other topical antiseptics are widely used, they are not included in the standard series recommended by the Spanish Contact Dermatitis and Skin Allergy Research Group for testing suspected allergic contact dermatitis (ACD). Furthermore, no recent studies have investigated the allergenic potential of merbromin. OBJECTIVE: To determine the allergenic potential of merbromin and compare it with that of other topical antiseptics widely used in clinical practice, including povidone-iodine, chlorhexidine, and eosin...
September 29, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28963158/antisepsis-of-the-skin-before-spinal-surgery-with-povidone-iodine-alcohol-followed-by-chlorhexidine-gluconate-alcohol-versus-povidone-iodine-alcohol-applied-twice-for-the-prevention-of-contamination-of-the-wound-by-bacteria-a-randomised-controlled-trial
#12
RANDOMIZED CONTROLLED TRIAL
S Patrick, A McDowell, A Lee, A Frau, U Martin, E Gardner, G McLorinan, N Eames
AIMS: The aim of this study was to determine whether the sequential application of povidone iodine-alcohol (PVI) followed by chlorhexidine gluconate-alcohol (CHG) would reduce surgical wound contamination to a greater extent than PVI applied twice in patients undergoing spinal surgery. PATIENTS AND METHODS: A single-centre, interventional, two arm, parallel group randomised controlled trial was undertaken, involving 407 patients who underwent elective spinal surgery...
October 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28872735/in-vitro-efficacy-of-disinfectants-utilised-for-skin-decolonisation-and-environmental-decontamination-during-a-hospital-outbreak-with-candida-auris
#13
Alireza Abdolrasouli, Darius Armstrong-James, Lisa Ryan, Silke Schelenz
Candida auris has caused nosocomial infections and transmissions within hospital settings. As little is known about the efficacy of skin and environmental decontamination products to kill C. auris, this study investigated the in vitro activity of chlorine, chlorhexidine, iodine povidone and vaporised hydrogen peroxide products against C. auris. H2 O2 vapour showed 96.6%-100% effective killing of C. auris. All isolates were inhibited by chlorhexidine gluconate concentrations at 0.125%-1.5% and for iodinated povidone at 0...
September 5, 2017: Mycoses
https://www.readbyqxmd.com/read/28865738/yeasticidal-activity-of-chemical-disinfectants-and-antiseptics-against-candida-auris
#14
G Moore, S Schelenz, A M Borman, E M Johnson, C S Brown
Candida auris appears to be transmitted readily between patients, yet information regarding the efficacy of environmental disinfection and skin decolonization is lacking. A quantitative suspension test (EN 13624:2013) was used to evaluate the yeasticidal activity of different chemical disinfectants and antiseptics against C. auris and Candida albicans. When tested in suspension, both a chlorine-based disinfectant and iodine-based skin antiseptic were effective against C. auris, suggesting that their use could reduce environmental contamination and skin colonization, respectively, if applied appropriately...
September 1, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28817989/optimal-skin-antiseptic-agents-for-prevention-of-surgical-site-infection-in-cesarean-section-a-meta-analysis-with-trial-sequential-analysis
#15
Huaping Huang, Guirong Li, Haiyan Wang, Mei He
PURPOSE: The best choice of antiseptic agent for skin preparation at cesarean section remains controversial. We performed this meta-analysis to assess whether chlorhexidine (CH)-based skin antisepsis was more effective than povidone iodine (PI)-based antisepsis for the prevention of surgical site infection (SSI) after cesarean section. METHODS: PubMed, EMBASE, and the Cochrane Library were systematically searched to identify English publications that compared chlorhexidine gluconate (CH) as a skin preparation agent with PI in cesarean section...
August 30, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28809751/influence-of-topical-iodine-containing-antiseptics-used-during-delivery-on-recall-rate-of-congenital-hypothyroidism-screening-program
#16
Majid Valizadeh, Farzaneh Moezzi, Zohreh Khavassi, Mohammad Movahedinia, Seideh Mazloomzadeh, Ladan Mehran
BACKGROUND: The proportion of newborns recalled during neonatal screening programs for congenital hypothyroidism (CH) varies substantially by country and may be higher in settings where povodine iodine (PVP-I) is used during delivery. We assessed this hypothesis by substituting PVP-I for chlorhexidine (CHL) and evaluated the reduction in the recall rate of the Irainian newborn screening program. METHODS: This study investigated 2282 neonates of mothers admitted to a local hospital for delivery between December 2012 and October 2013...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28796148/pain-and-antisepsis-after-ocular-administration-of-povidone-iodine-versus-chlorhexidine
#17
Carmen Oakley, Penny Allen, Joobin Hooshmand, Brendan J T Vote
PURPOSE: To investigate ocular bacterial count before and after antisepsis with aqueous chlorhexidine (AC) or povidone-iodine (PI) and to assess discomfort with each agent. METHODS: Bacterial swabs were taken from participants' eyes before and after antisepsis. These underwent microscopy, culture, and sensitivity testing. Aqueous chlorhexidine drops were administered to left eyes and PI to right eyes. Participants rated their pain (scale 0-10) for each eye but were blinded to the type of drop...
August 8, 2017: Retina
https://www.readbyqxmd.com/read/28774612/biomarkers-of-end-of-shift-exposure-to-disinfection-byproducts-in-nurses
#18
Solomon Ioannou, Xanthi D Andrianou, Pantelis Charisiadis, Konstantinos C Makris
Increased disinfectant use commonly takes place in hospitals and other health care settings. A cross-sectional study among active nurses in two Cypriot public hospitals (n=179) was conducted to examine the prevalence of exposure to disinfection byproducts (DBPs), such as trihalomethanes (THMs) using both self-reported information and biomarker measurements. The objectives of this study were to: i) quantify the magnitude and variability of occupational exposure to disinfectants/DBPs in nurses, ii) generate job exposure matrices (JEM) and job task exposure matrices (JTEM) for disinfectants, and iii) assess the major determinants of urinary THMs in nurses...
August 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28700086/antiseptics-for-burns
#19
REVIEW
Gill Norman, Janice Christie, Zhenmi Liu, Maggie J Westby, Jayne M Jefferies, Thomas Hudson, Jacky Edwards, Devi Prasad Mohapatra, Ibrahim A Hassan, Jo C Dumville
BACKGROUND: Burn wounds cause high levels of morbidity and mortality worldwide. People with burns are particularly vulnerable to infections; over 75% of all burn deaths (after initial resuscitation) result from infection. Antiseptics are topical agents that act to prevent growth of micro-organisms. A wide range are used with the intention of preventing infection and promoting healing of burn wounds. OBJECTIVES: To assess the effects and safety of antiseptics for the treatment of burns in any care setting...
July 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28697103/chlorhexidine-alcohol-compared-with-povidone-iodine-for-preoperative-topical-antisepsis-for-abdominal-hysterectomy
#20
COMPARATIVE STUDY
Shitanshu Uppal, Ali Bazzi, R Kevin Reynolds, John Harris, Mark D Pearlman, Darrell A Campbell, Daniel M Morgan
OBJECTIVE: To compare preoperative chlorhexidine-alcohol topical antiseptic agent with povidone-iodine in patients undergoing abdominal hysterectomy for benign indications. METHODS: A retrospective cohort study of patients undergoing abdominal hysterectomy from July 2012 to February 2015 in the Michigan Surgical Quality Collaborative was performed. The primary exposure was the use of chlorhexidine-alcohol or povidone-iodine. The primary outcome was surgical site infection within 30 days...
August 2017: Obstetrics and Gynecology
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