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ultrasound of the spleen leukemia

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https://www.readbyqxmd.com/read/26771322/chronic-t-cell-lymphocytic-leukemia-in-a-black-swan-cygnus-atratus-diagnosis-treatment-and-pathology
#1
Kristin M Sinclair, Michelle G Hawkins, Lewis Wright, Richard P Chin, Sean D Owens, David Sanchez-Migallon Guzman, Michael S Kent, H L Shivaprasad BVSc
An asymptomatic 14-year old, male black swan ( Cygnus atratus ) housed at a zoological institution was presented for routine preshipment examination. Hematologic findings indicated that the bird had a severe lymphocytic leukocytosis, consistent with chronic lymphocytic leukemia. Radiographs showed the presence of multiple soft tissue masses within the caudal coelomic cavity; ultrasound showed one mass to be an enlarged spleen, a cystic mass near the gonads, and a mass suspected to be associated with the ventriculus...
December 2015: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/26451185/does-level-of-training-influence-the-ability-to-detect-hepatosplenomegaly-in-children-with-leukemia
#2
Donna L Johnston, Janelle Cyr
BACKGROUND: Children with leukemia often have hepatosplenomegaly present. This can be diagnosed with physical examination and confirmed with ultrasound. We sought to determine if level of training influenced the ability to detect hepatosplenomegaly. METHODS: All children diagnosed with leukemia during the past 5 years were reviewed. The training level of the examiner, the documentation of hepatosplenomegaly, and the ultrasound findings were collected and analyzed...
2012: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/26182133/multiple-splenic-nodules-with-fever-a-case-of-splenic-abscess-due-to-propionibacterium-acnes
#3
Sho Kiritani, Junichi Kaneko, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Yasuhiko Sugawara, Norihiro Kokudo
A 64-year-old man with a history of chronic lymphocytic leukemia (CLL) presented in the hematology department due to remarkable leukocytosis and progressing anemia. Ultrasound confirmed splenomegaly and plain computed tomography revealed multiple hypoattenuating areas in the large spleen. Following a clinical diagnosis of relapse of CLL, he underwent treatment with fludarabine, cyclophosphamide, and rituximab (FC-R). After five cycles of FC-R treatment, his leukocyte count and hemoglobin level were normalized, and the size of the spleen also decreased...
December 2013: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/25895328/-a-case-of-acute-myelocytic-leukemia-suffered-throat-pain-as-initial-symptom
#4
Danhong Qiu, Gang Wu
We report a case of a 47-year-old man who firstly complained of throat pain for half a month accompanied with fever. Specialized examination showed tonsils' hypertrophy and the laryngoscope found his right vocal cord was swelling and hyperemia. The routine blood test counted white blood cell as 31 x 10(9)/L, lymphocyte as 30. 84 x 10(9)/L while prolymphocyte could be seen with microscope. After that B-ultrasound scan gave spleen hypertrophy and multi-lymphatic-node enlargement. Peripheral blood flowcytometry and bone marrow biopsy finally diagnosed the man as actue myelocytic leukemia...
December 2014: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/25424765/acute-undifferentiated-leukaemia-in-a-dog
#5
A Miglio, M T Antognoni, B Miniscalco, D Caivano, E Lepri, F Birettoni, V Mangili
BACKGROUND: Acute undifferentiated leukaemia (AUL) is considered a separate entity in the context of acute leukaemias. AUL is extremely rare in both humans and dogs, has a rapid clinical course and does not respond to treatment. It is characterised by the presence of blast cells within the bone marrow and/or peripheral blood at levels ≥ 20% and even up to 100% of all nucleated cells. Blast cells are unable to be differentiated on morphological, cytochemical and phenotypic criteria into myeloid or lymphoid lineages because of their immaturity and/or atypia...
December 2014: Australian Veterinary Journal
https://www.readbyqxmd.com/read/25340526/nilotinib-is-more-potent-than-imatinib-for-treating-plexiform-neurofibroma-in-vitro-and-in-vivo
#6
Jiang Wei, Marcus Freytag, Yvonne Schober, Wolfgang A Nockher, Victor F Mautner, Reinhard E Friedrich, Paul W Manley, Lan Kluwe, Andreas Kurtz
Plexiform neurofibromas (PNFs) are benign nerve sheath tumors mostly associated with neurofibromatosis type 1. They often extend through multiple layers of tissue and therefore cannot be treated satisfactorily by surgery. Nilotinib is a tyrosine kinase inhibitor used to treat leukemia, with advantages over the prototype imatinib in terms of potency and selectivity towards BCR-ABL, and the DDR, PDGFR, and KIT receptor kinases. In this study, we compared efficacies of the two drugs on cultured cells of PNF in vitro and on xenografted tumor fragments on sciatic nerve of athymic nude mice...
2014: PloS One
https://www.readbyqxmd.com/read/24100280/sinoporphyrin-sodium-a-novel-sensitizer-in-sonodynamic-therapy
#7
Jianmin Hu, Xiaobing Wang, Kun Zhang, Pan Wang, Xiaomin Su, Yixiang Li, Zuxian Huang, Quanhong Liu
The aim of this paper was to investigate whether sinoporphyrin sodium (DVDMS) could be a novel sonosensitizer in sonodynamic therapy. We used two kinds of leukemia cells (K562, U937) as main tumor cell models and cells (peripheral blood mononuclear cells, spleen lymphocytes) separated from healthy ICR mice as normal cell models. The multivolume spectrophotometer system and fluorescence spectrophotometer were used to determine the spectral characteristics of DVDMS. The uptake of DVDMS by tumor cells and normal cells was measured by flow cytometry...
February 2014: Anti-cancer Drugs
https://www.readbyqxmd.com/read/23139997/massive-splenomegaly-in-acute-erythroid-leukaemia-fab-class-m6-an-unusual-presentation
#8
Syed Furqan Haider Sherazi, Zeeshan Butt
AML-M6 has a peak incidence in the seventh decade with slight male preponderance, and can also present at a younger age. The usual features are anaemia, thrombocytopenia, malaise, fatigue, easy bruising, epistaxis and petechiae. Splenomegaly may occur in 20-40 % of the cases but massive splenomegaly is rare presentation and have been only reported once in humans and once in animals. A 22 year Asian female, presented with fatigue, pallor, mild jaundice, exertional dyspnoea, epigastric pain, tender right hypochondrium and massive splenomegaly...
September 2012: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/23126049/-acute-renal-failure-as-first-manifestation-of-b-cll
#9
Inga Mandac Rogulj, Ingrid Prkacin, Mirjana Sabljar-Matovinović, Danica Galesić Ljubanović, Dunja Sustercić
In December 2005, the 55-year-old patient was hospitalized because of acute kidney failure and suspected hemorrhagic fever. The physical examination showed splenomegaly (spleen ultrasound-18 cm in large diameter, and 11 cm by palpation) with thrombocytopenia and anemia. He underwent kidney biopsy which described infiltration of small B cell lymphocytes with positive lambda chains. His bone marrow showed infiltration of atypical lymphocytes, and flow cytometry was typical of B-cell CLL. Patient started therapy with corticosteroids (methylprednisolone 80 mg iv) and continued treatment with prednisone (Decortin 20 mg tablets) and chlorambucil (Leukeran 16 mg tablets) through three days...
September 2011: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
https://www.readbyqxmd.com/read/22662644/sarcoidosis-and-multiple-sclerosis-systemic-toxicity-associated-with-the-use-of-interferon-beta-therapy
#10
C Carbonelli, S Montepietra, A Caruso, A Cavazza, C Feo, F Menzella, L Motti, L Zucchi
Sarcoidosis is a multi-systemic inflammatory disease of unknown origin characterized by the presence of noncaseating epitheloid cell granulomas in multiple organs. Diagnosis is made on the basis of a compatible clinical-radiological scenario and the histological demonstration of the typical granulomas in the affected tissues. Interferons are immuno-modulators that have been used in a wide range of diseases, including hepatitis C virus infection, multiple sclerosis, and multiple myeloma and other types of tumours, including leukemia, lymphomas, Kaposi's sarcoma, and melanoma...
March 2012: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/21913980/gastrointestinal-manifestations-of-leukemia
#11
REVIEW
Ellen C Ebert, Klaus D Hagspiel
Gastrointestinal (GI) manifestations of leukemia occur in up to 25% of patients at autopsy, generally during relapse. Its presence varies with the type of leukemia and has been decreasing over time due to improved chemotherapy. Gross leukemic lesions are most common in the stomach, ileum, and proximal colon. Leukemia in the esophagus and stomach includes hemorrhagic lesions from petechiae to ulcers, leukemic infiltrates, pseudomembranous esophagitis, and fungal esophagitis. Lesions in the small and large bowel are usually hemorrhagic or infiltrative...
March 2012: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/21900964/a-retroviral-vector-suitable-for-ultrasound-image-guided-gene-delivery-to-mouse-brain
#12
J Jang, K Yoon, D W Hwang, D S Lee, S Kim
Gene transfer to the early-stage embryonic brain using the ultrasound image-guided gene delivery (UIGD) technique has proven to be valuable for investigating brain development. Thus far, this technology has been restricted to the study of embryonic neurogenesis. When this technique is designed to be employed for the study in adult animals, a long-term stable gene expression will be required. We attempted to develop a retroviral vector suitable for expressing exogenous genes in the brains of postnatal and adult mice in the context of the UIGD technique...
April 2012: Gene Therapy
https://www.readbyqxmd.com/read/19663087/-fulminant-non-hodgkin-lymphoma-presenting-as-lactic-acidosis-and-acute-liver-failure-case-report-and-literature-review
#13
REVIEW
Guillermo Flores Padilla, Marco Antonio Alba Garibay, Haiko Nellen Hummel, Renata Avila, Alejandra Méndez, Rocío Ramírez
UNLABELLED: Hepatic dysfunction caused by malignancy is uncommon and can be the result of primary hepatocellular carcinoma, liver metastasis, secondary malignancies, or a complication of chemotherapeutic agents. Hematological malignancies, as leukemia, non-Hodgkin lymphoma, and Hodgkin lymphoma, typically do not result in hepatic dysfunction and rarely manifest as fulminant liver failure. CASE PRESENTATION: A 43 year-old male was referred with 2-week diarrhea, nausea and vague abdominal discomfort...
June 2009: Acta Gastroenterologica Latinoamericana
https://www.readbyqxmd.com/read/19094620/-the-value-of-spleen-sub-pedicle-two-steps-severance-with-ligasure-in-laparoscopic-splenectomy
#14
Guang-yi Wang, Ya-hui Liu, Guo-yue Lü, Kai Liu, Wei Zhang, Nan Li, Yu-quan Tan
OBJECTIVE: To evaluate the safety and utility of the methods of spleen sub-pedicle two steps severance with LigaSure Vessel Sealing System combined with ultrasound scalpel to resect peri-splenic ligaments during laparoscopic splenectomy. METHODS: The methods and the curative effect of 32 patients with laparoscopic splenectomy performed by the way as mentioned above were summarized and analyzed. 4 males, 28 females, median 36 years (range 16 - 64 years). Mean dimensions of spleens were 17 cm (range 11 - 23 cm)...
October 1, 2008: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/18717148/an-unusual-case-of-febrile-neutropenia-acute-myeloid-leukemia-presenting-as-myeloid-sarcoma-of-the-spleen
#15
Wei-Liang Chen, Yu-Juei Hsu, Wei-Chi Tsai, Yu-Tzu Tsao
Differential diagnosis of a focal splenic lesion in the context of acute leukemia is quite challenging. A 58-year-old woman presented with a 3-day history of fever and abdominal pain. The results of hematological work-up were consistent with acute myeloblastic leukemia (M2, French-American-British classification). Being susceptible to infection in this leukemic patient with severe neutropenia, a diagnosis of splenic abscess was straightforward, plausibly supported by the radiographic findings. Despite empiric broad-spectrum antibiotic treatment, hyperleukocytosis with resultant pulmonary leukostasis supervened...
August 2008: Journal of the National Medical Association
https://www.readbyqxmd.com/read/18181187/hairy-cell-leukemia-presenting-as-a-discrete-liver-mass-diagnosis-by-fine-needle-aspiration-biopsy
#16
Ali Mohammed Al-Za'abi, Scott L Boerner, William Geddie
Hairy cell leukemia, a chronic low-grade lymphoproliferative disorder first recognized in mid 1920's typically involves the lymphoreticular system, especially the spleen and the bone marrow. Clinically, it tends to present with pancytopenia and splenomegaly. Liver involvement, if present, is usually in a sinusoidal and a periportal pattern. We report a case of hairy cell leukemia associated with a liver mass 20 years after the initial presentation. To our knowledge, this is the first case of hairy cell leukemia presenting as a solid liver mass diagnosed by a percutaneous ultrasound guided fine needle aspiration biopsy to be reported in the English literature...
February 2008: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/17536578/unusual-presentation-of-spontaneous-splenic-rupture
#17
Preeti Dalawari, John C Vandover, Robert A Rosenbaum
We report a case of a 47-year-old man who presented with hypotension after 2 weeks of fatigue and upper respiratory infection symptoms, and rapidly deteriorated in the emergency department. A bedside ultrasound revealed free intraperitoneal fluid, a subsequent diagnostic peritoneal lavage showed hemoperitoneum, and a laparotomy confirmed a splenic rupture. Pathology results revealed a relatively rare form of leukemia, known as hairy cell leukemia, leading to this presentation. We discuss the differential diagnosis of spontaneous (or without antecedent trauma) splenic rupture with a review of hairy cell leukemia, and stress the importance of keeping a high index of suspicion for medical diseases that affect the spleen...
May 2007: Delaware Medical Journal
https://www.readbyqxmd.com/read/16707371/diagnosis-of-deep-seated-lymphoma-and-leukemia-by-endoscopic-ultrasound-guided-fine-needle-aspiration-biopsy
#18
Judith L Pugh, Nirag C Jhala, Mohamad A Eloubeidi, David C Chhieng, Isam A Eltoum, D Ralph Crowe, Shyam Varadarajulu, Darshana N Jhala
We retrospectively studied the use of endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) as a tool for the diagnosis of deep-seated lymphoma. An on-site assessment at the time of EUS-FNAB was performed by a cytopathologist using Diff-Quik (American Scientific Products, McGraw Park, IL) stain. In addition, Papanicolaou stains were performed on EUS-FNAB smears, immunohistochemical stains were performed on cell blocks, and additional samples were sent for flow cytometric analysis. Final cytologic diagnosis was correlated with surgical pathology and/or clinical follow-up...
May 2006: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/16430774/hairy-cell-leukemia-a-diagnosis-by-endoscopic-ultrasound-guided-fine-needle-aspiration
#19
Regina S Meara, Vishnu Reddy, Juan Pablo Arnoletti, Darshana Jhala, Shyam Varadarajulu, Nirag Jhala
BACKGROUND: Endosonography (EUS) guided FNA is a relatively new imaging modality which is increasingly used for sampling deep-seated lymph nodes in the diagnosis and staging of various malignancies, both primary as well as metastatic. It is also useful for staging of non-Hodgkin's lymphoma as well as diagnosing recurrence. The diagnosis of leukemia on FNA samples from deep-seated lymphadenopathy poses an even greater challenge. Hairy cell leukemia (HCL) is an uncommon, but distinct, lympho-proliferative disorder of B cell origin...
2006: CytoJournal
https://www.readbyqxmd.com/read/12434439/-renal-lesions-in-patients-with-chronic-lymphocytic-leukemia
#20
S S Bessmel'tsev, K M Abdulkadyrov
32 patients with chronic lymphoid leukemia (CLL) were examined to specify reasons of renal damage. Measurements were made of blood urea, creatinine, total protein, electrolytes, uric acid. Also, urinary sediment, diurnal loss of protein and creatinine with urine, glomerular filtration rate, concentration ability of the kidneys were studied. Urinary system was assessed by ultrasound. Most CLL patients studied had renal affection characteristic for chronic pyelonephritis with chronic renal insufficiency. The ultrasonic investigation stated reduced size of the kidneys, thinning of the cortex, extension of the renal pelvis and calyces, concrements...
March 1999: Urologii︠a︡ i Nefrologii︠a︡
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