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https://www.readbyqxmd.com/read/27935843/siderophores-more-than-stealing-iron
#1
Judith Behnsen, Manuela Raffatellu
Siderophores are small molecular iron chelators that are produced by microbes and whose most notable function is to sequester iron from the host and provide this essential metal nutrient to microbes. Recent studies have proposed additional, noncanonical roles for siderophores, including the acquisition of noniron metals and modulation of host functions. Recently, Holden et al. (V. I. Holden, P. Breen, S. Houle, C. M. Dozois, and M. A. Bachman, mBio 7:e01397-16, 2016, http://dx.doi.org/10.1128/mBio.01397-16) showed that siderophores secreted by Klebsiella pneumoniae during lung infection induce stabilization of the transcription factor HIF-1α, increase the expression of proinflammatory cytokines in the lung, and promote dissemination of K...
November 15, 2016: MBio
https://www.readbyqxmd.com/read/27873224/therapeutic-potential-of-transdermal-glyceryl-trinitrate-in-the-management-of-acute-stroke
#2
Jason P Appleton, Nikola Sprigg, Philip M Bath
The nitric oxide donor, glyceryl trinitrate (GTN), is a candidate treatment for the management of acute stroke with haemodynamic and potential reperfusion and neuroprotective effects. When administered as a transdermal patch during the acute and subacute phases after stroke, GTN was safe, lowered blood pressure, maintained cerebral blood flow, and did not induce cerebral steal or alter functional outcome. However, when given within 6 h of stroke onset, GTN reduced death and dependency (odds ratio 0.52; 95% confidence interval 0...
November 21, 2016: CNS Drugs
https://www.readbyqxmd.com/read/27856450/is-more-area-level-crime-associated-with-more-sitting-and-less-physical-activity-longitudinal-evidence-from-37-162-australians
#3
Thomas Astell-Burt, Xiaoqi Feng, Gregory S Kolt, Bin Jalaludin
Does a rise in crime result in increased sitting time and a reduction in physical activity? We used unobserved ("fixed")-effects models to examine associations between change in objectively measured crime (nondomestic violence, malicious damage, breaking and entering, and stealing, theft, and robbery) in Australia and measures of sitting time, walking, and moderate-to-vigorous physical activity (MVPA) in a residentially stable sample of 17,474 men and 19,688 women at baseline (2006-2008) and follow-up (2009-2010)...
November 17, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27855212/microsporidia-why-make-nucleotides-if-you-can-steal-them
#4
REVIEW
Paul Dean, Robert P Hirt, T Martin Embley
Microsporidia are strict obligate intracellular parasites that infect a wide range of eukaryotes including humans and economically important fish and insects. Surviving and flourishing inside another eukaryotic cell is a very specialised lifestyle that requires evolutionary innovation. Genome sequence analyses show that microsporidia have lost most of the genes needed for making primary metabolites, such as amino acids and nucleotides, and also that they have only a limited capacity for making adenosine triphosphate (ATP)...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27835916/neuropsychological-performance-after-brain-arteriovenous-malformations-treatment
#5
Ondrej Bradac, Alice Pulkrabkova, Patricia de Lacy, Vladimir Benes
Background The treatment of brain arteriovenous malformations (AVMs) has been studied extensively. With the use of the Spetzler-Martin (S-M) grading system, patients can be informed appropriately about their possible surgical risks. This does not hold true for their neuropsychological sequelae, which have not been studied widely. We evaluated the neuropsychological outcome of our patients treated for brain AVMs. Methods Of 113 patients treated for a brain AVM between 2001 and 2009, 66 patients were enrolled in the study...
November 11, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27824958/the-value-of-exercise-spet-for-the-detection-of-coronary-artery-steal-syndrome-secondary-to-unligated-major-side-branch-of-left-internal-mammary-artery
#6
Osman Beton, Hakki Kaya, Ozan Kandemir, Buket Alibazoglu, Haluk Alibazoglu, Ercan Karabey, Okan Onur Turgut, Mehmet Birhan Yilmaz
OBJECTIVE: The clinical significance of unligated major left internal mammary artery (LIMA)-side branches (SB) remains controversial in patients with previous coronary artery bypass graft (CABG) surgery. The aim of this study was to investigate the clinical significance of unligated major LIMA-SB by using exercise myocardial perfusion imaging (MPI) with single-photon emission tomography. SUBJECTS AND METHODS: We conducted a retrospective analysis of 2819 consecutive patients who underwent diagnostic angiography...
November 8, 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27801662/coronary-fistula-and-myocardial-ischemia-what-is-the-relationship
#7
Ashish H Shah, Robert J Cusimano, Maral Ouzounian
Coronary artery fistula is a rare anomaly; large fistulae may result in myocardial ischemia from coronary steal. We present the case of a 73-year-old male who presented with exertional angina; imaging demonstrated severe coronary artery disease and a large coronary artery fistula. Ligation of the fistula resulted in severe right ventricular failure and cardiogenic shock. After reestablishing flow to the fistula, the patient recovered. We speculate that the ischemia-induced angiogenesis from the congenitally present fistula made what may have otherwise been an innocent fistula into an important nutritive supply, which remained important despite distal revascularization...
November 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27799374/where-did-the-clot-go-an-unusual-complication-of-mechanical-thrombectomy-caused-by-malignancy-related-subclavian-steal-phenomenon-in-a-patient-with-acute-basilar-artery-occlusion
#8
Nikkie Randhawa, Jonathan P Squires, Manraj Kanwal Singh Heran, Sharanpal K Mann
Subclavian steal is a relatively common vascular phenomenon usually caused by atherosclerotic disease. While symptoms are rare, arm claudication of the ipsilateral limb is most common, with paroxysmal symptoms of vertebrobasilar insufficiency (often exercise induced) being relatively uncommon. Here we present a case of brachial artery embolism during mechanical thrombectomy for basilar artery thrombosis, secondary to subclavian steal phenomenon. This atypical and potentially irreversible complication should be considered in patients with acute ischemic stroke undergoing neurointerventional management when subclavian steal is discovered angiographically...
October 31, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27797875/where-did-the-clot-go-an-unusual-complication-of-mechanical-thrombectomy-caused-by-malignancy-related-subclavian-steal-phenomenon-in-a-patient-with-acute-basilar-artery-occlusion
#9
Nikkie Randhawa, Jonathan P Squires, Manraj Kanwal Singh Heran, Sharanpal K Mann
Subclavian steal is a relatively common vascular phenomenon usually caused by atherosclerotic disease. While symptoms are rare, arm claudication of the ipsilateral limb is most common, with paroxysmal symptoms of vertebrobasilar insufficiency (often exercise induced) being relatively uncommon. Here we present a case of brachial artery embolism during mechanical thrombectomy for basilar artery thrombosis, secondary to subclavian steal phenomenon. This atypical and potentially irreversible complication should be considered in patients with acute ischemic stroke undergoing neurointerventional management when subclavian steal is discovered angiographically...
October 25, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27748709/investigating-the-vascular-phenotype-of-subcutaneously-and-orthotopically-propagated-pc3-prostate-cancer-xenografts-using-combined-carbogen-ultrasmall-superparamagnetic-iron-oxide-mri
#10
Jake S Burrell, Simon Walker-Samuel, Jessica K R Boult, Lauren C J Baker, Yann Jamin, Jane Halliday, John C Waterton, Simon P Robinson
The aim of this study was to use the combined carbogen-ultrasmall superparamagnetic iron oxide (CUSPIO) magnetic resonance imaging (MRI) method, which uses spatial correlations in independent susceptibility imaging biomarkers, to investigate and compare the impact of tumor size and anatomical site on vascular structure and function in vivo. Mice bearing either subcutaneous or orthotopic PC3 LN3 prostate tumors were imaged at 7 T, using a multi-gradient echo sequence to quantify R2, before and during carbogen (95% O2/5% CO2) breathing, and subsequently following intravenous administration of USPIO particles...
October 2016: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/27739574/the-dril-procedure-for-arteriovenous-access-ischemic-steal-a-controversial-approach
#11
Ingemar Davidson, Gerald Beathard, Maurizio Gallieni, John Ross
Because of changes in the patient population clinical presentation, most notably forearm atherosclerosis and with new technologies, this editorial addresses the current validity of the DRIL procedure as a safe option in treating AVAIS.
October 8, 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/27739573/arteriovenous-access-ischemic-steal-avais-in-haemodialysis-a-consensus-from-the-charing-cross-vascular-access-masterclass-2016
#12
Nicholas Inston, Harry Schanzer, Matthias Widmer, Colin Deane, Jason Wilkins, Ingemar Davidson, Paul Gibbs, Jeurgen Zanow, Pierre Bourquelot, Domenico Valenti
Arteriovenous access ischaemic steal (AVAIS) is a serious and not infrequent complication of vascular access. Pathophysiology is key to diagnosis, investigation and management. Ischaemia distal to an AV access is due to multiple factors. Clinical steal is not simply blood diversion but pressure changes within the adapted vasculature with distal hypoperfusion and resultant poor perfusion pressures in the distal extremity. Reversal of flow within the artery distal to the AV access may be seen but this is not associated with ischaemia in most cases...
October 12, 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/27729852/reward-vs-retaliation-the-role-of-the-mesocorticolimbic-salience-network-in-human-reactive-aggression
#13
Gabriela Gan, Rebecca N Preston-Campbell, Scott J Moeller, Joel L Steinberg, Scott D Lane, Thomas Maloney, Muhammad A Parvaz, Rita Z Goldstein, Nelly Alia-Klein
The propensity for reactive aggression (RA) which occurs in response to provocation has been linked to hyperresponsivity of the mesocorticolimbic reward network in healthy adults. Here, we aim to elucidate the role of the mesocorticolimbic network in clinically significant RA for two competing motivated behaviors, reward-seeking vs. retaliation. 18 male participants performed a variant of the Point-Subtraction Aggression Paradigm (PSAP) during functional magnetic resonance imaging (fMRI). We examined whether RA participants compared with non-aggressive controls would choose to obtain a monetary reward over the opportunity to retaliate against a fictitious opponent, who provoked the participant by randomly stealing money from his earnings...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27728000/a-rare-case-of-subclavian-steal-syndrome
#14
Veera Abhinav Chinta, Anupam Jena, S V Ramana Murthy, Bhagya Suneeta Meegada
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27716331/bedside-pda-ligation-in-premature-infants-less-than-28%C3%A2-weeks-and-1000-grams
#15
Mustafa Kemal Avsar, Tolga Demir, Cem Celiksular, Cenap Zeybek
BACKGROUND: PDA(Patent ductus arteriosus) is a common and clinically important condition which is presented with a number of hemodynamic and respiratory problems such as intraventricular hemorrhage, pulmonary hemorrhage and necrotizing enterocolitis due to increased pulmonary blood flow and stealing from systemic circulation. The incidence of PDA among the infants that were born before the 28th gestational week is as high as 70 %; and spontaneous closure rates in very-low-birth-weight premature neonates(VLBWPN) is around 34 %...
October 4, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27709306/axillo-iliac-arteriovenous-hemodialysis-graft-creation-with-an-early-cannulation-device
#16
Carlos A Hinojosa, Javier E Anaya-Ayala, Alejandra Lopez-Mendez, Zeniff Gomez-Arcive, Hugo Laparra-Escareno, Cesar Cuen-Ojeda, Rene Lizola, Adriana Torres-Machorro
Exhaustion of superficial veins coupled with the presence of intrathoracic central venous occlusions remains a significant obstacle for hemodialysis access creation; complex arteriovenous graft (AVG) configurations have been described. The axillary-iliac AVG was first reported in 1987, and few authors have explored this access. We evaluated our experience with this AVG configuration utilizing the early cannulation (EC) graft Flixene™ (Atrium ™, Hudson, NH, USA). Eight patients (75 % men; mean age 37 ± 10 years) with End-Stage Renal Disease (ESRD) underwent axillo-iliac AVG creation with Flixene™ grafts; all had exhausted peripheral veins, occluded thoracic central veins, and inadequate femoral veins...
October 5, 2016: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/27690501/alternative-and-complementary-reinforcers-as-mechanisms-linking-adolescent-conduct-problems-and-substance-use
#17
Rubin Khoddam, Adam M Leventhal
The present study tested the hypothesis that teens who engage in conduct problems are more likely to use substances because they engage in fewer alternative reinforcing (i.e., pleasurable) substance-free activities and more complementary reinforcing substance-associated activities. In a cross-sectional, correlational design, 9th grade students (N = 3,383; mean age = 14.6 years) in Los Angeles, California, U.S.A. completed surveys in 2013 measuring conduct problems (e.g., stealing, lying, getting in fights); alternative and complementary reinforcement; use of a number of licit, illicit, and prescription drugs; and other cofactors...
October 2016: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27684758/britain-honors-mary-seacole-with-a-memorial
#18
Dalia Sofer
Is the statue stealing the spotlight from the Lady with a Lamp? Some say yes.
October 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/27681008/using-cloud-models-of-heartbeats-as-the-entity-identifier-to-secure-mobile-devices
#19
Donglai Fu, Yanhua Liu
Mobile devices are extensively used to store more private and often sensitive information. Therefore, it is important to protect them against unauthorised access. Authentication ensures that authorised users can use mobile devices. However, traditional authentication methods, such as numerical or graphic passwords, are vulnerable to passive attacks. For example, an adversary can steal the password by snooping from a shorter distance. To avoid these problems, this study presents a biometric approach that uses cloud models of heartbeats as the entity identifier to secure mobile devices...
September 28, 2016: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/27666798/mastication-steal-syndrome
#20
C Miles Maliska, John Blebea, Kevin E Taubman
A 56-year-old female presented with episodic vertigo, dizziness and diplopia during meals and prolonged verbal presentations at work. Subsequent work-up included an eventual catheter-based-angiogram revealing an ostial left ECA (external carotid artery) occlusion with reconstituted retrograde flow via a variant collateral branch from the dominant left vertebral artery (VA). The findings demonstrate that repetitive activities involving craniofacial muscular systems supplied by the ECA result in a symptomatic arterial steal syndrome via the enhanced diverted flow from the collateral vertebral-basilar arterial system...
September 22, 2016: Annals of Vascular Surgery
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