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Jake S Burrell, Simon Walker-Samuel, Jessica K R Boult, Lauren C J Baker, Yann Jamin, Jane Halliday, John C Waterton, Simon P Robinson
The aim of this study was to use the combined carbogen-ultrasmall superparamagnetic iron oxide (CUSPIO) magnetic resonance imaging (MRI) method, which uses spatial correlations in independent susceptibility imaging biomarkers, to investigate and compare the impact of tumor size and anatomical site on vascular structure and function in vivo. Mice bearing either subcutaneous or orthotopic PC3 LN3 prostate tumors were imaged at 7 T, using a multi-gradient echo sequence to quantify R2, before and during carbogen (95% O2/5% CO2) breathing, and subsequently following intravenous administration of USPIO particles...
October 2016: Topics in Magnetic Resonance Imaging: TMRI
Ingemar Davidson, Gerald Beathard, Maurizio Gallieni, John Ross
Because of changes in the patient population clinical presentation, most notably forearm atherosclerosis and with new technologies, this editorial addresses the current validity of the DRIL procedure as a safe option in treating AVAIS.
October 8, 2016: Journal of Vascular Access
Nicholas Inston, Harry Schanzer, Matthias Widmer, Colin Deane, Jason Wilkins, Ingemar Davidson, Paul Gibbs, Jeurgen Zanow, Pierre Bourquelot, Domenico Valenti
Arteriovenous access ischaemic steal (AVAIS) is a serious and not infrequent complication of vascular access. Pathophysiology is key to diagnosis, investigation and management. Ischaemia distal to an AV access is due to multiple factors. Clinical steal is not simply blood diversion but pressure changes within the adapted vasculature with distal hypoperfusion and resultant poor perfusion pressures in the distal extremity. Reversal of flow within the artery distal to the AV access may be seen but this is not associated with ischaemia in most cases...
October 12, 2016: Journal of Vascular Access
Gabriela Gan, Rebecca N Preston-Campbell, Scott J Moeller, Joel L Steinberg, Scott D Lane, Thomas Maloney, Muhammad A Parvaz, Rita Z Goldstein, Nelly Alia-Klein
The propensity for reactive aggression (RA) which occurs in response to provocation has been linked to hyperresponsivity of the mesocorticolimbic reward network in healthy adults. Here, we aim to elucidate the role of the mesocorticolimbic network in clinically significant RA for two competing motivated behaviors, reward-seeking vs. retaliation. 18 male participants performed a variant of the Point-Subtraction Aggression Paradigm (PSAP) during functional magnetic resonance imaging (fMRI). We examined whether RA participants compared with non-aggressive controls would choose to obtain a monetary reward over the opportunity to retaliate against a fictitious opponent, who provoked the participant by randomly stealing money from his earnings...
2016: Frontiers in Behavioral Neuroscience
Veera Abhinav Chinta, Anupam Jena, S V Ramana Murthy, Bhagya Suneeta Meegada
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Mustafa Kemal Avsar, Tolga Demir, Cem Celiksular, Cenap Zeybek
BACKGROUND: PDA(Patent ductus arteriosus) is a common and clinically important condition which is presented with a number of hemodynamic and respiratory problems such as intraventricular hemorrhage, pulmonary hemorrhage and necrotizing enterocolitis due to increased pulmonary blood flow and stealing from systemic circulation. The incidence of PDA among the infants that were born before the 28th gestational week is as high as 70 %; and spontaneous closure rates in very-low-birth-weight premature neonates(VLBWPN) is around 34 %...
October 4, 2016: Journal of Cardiothoracic Surgery
Carlos A Hinojosa, Javier E Anaya-Ayala, Alejandra Lopez-Mendez, Zeniff Gomez-Arcive, Hugo Laparra-Escareno, Cesar Cuen-Ojeda, Rene Lizola, Adriana Torres-Machorro
Exhaustion of superficial veins coupled with the presence of intrathoracic central venous occlusions remains a significant obstacle for hemodialysis access creation; complex arteriovenous graft (AVG) configurations have been described. The axillary-iliac AVG was first reported in 1987, and few authors have explored this access. We evaluated our experience with this AVG configuration utilizing the early cannulation (EC) graft Flixene™ (Atrium ™, Hudson, NH, USA). Eight patients (75 % men; mean age 37 ± 10 years) with End-Stage Renal Disease (ESRD) underwent axillo-iliac AVG creation with Flixene™ grafts; all had exhausted peripheral veins, occluded thoracic central veins, and inadequate femoral veins...
October 5, 2016: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
Rubin Khoddam, Adam M Leventhal
The present study tested the hypothesis that teens who engage in conduct problems are more likely to use substances because they engage in fewer alternative reinforcing (i.e., pleasurable) substance-free activities and more complementary reinforcing substance-associated activities. In a cross-sectional, correlational design, 9th grade students (N = 3,383; mean age = 14.6 years) in Los Angeles, California, U.S.A. completed surveys in 2013 measuring conduct problems (e.g., stealing, lying, getting in fights); alternative and complementary reinforcement; use of a number of licit, illicit, and prescription drugs; and other cofactors...
October 2016: Experimental and Clinical Psychopharmacology
Dalia Sofer
Is the statue stealing the spotlight from the Lady with a Lamp? Some say yes.
October 2016: American Journal of Nursing
Donglai Fu, Yanhua Liu
Mobile devices are extensively used to store more private and often sensitive information. Therefore, it is important to protect them against unauthorised access. Authentication ensures that authorised users can use mobile devices. However, traditional authentication methods, such as numerical or graphic passwords, are vulnerable to passive attacks. For example, an adversary can steal the password by snooping from a shorter distance. To avoid these problems, this study presents a biometric approach that uses cloud models of heartbeats as the entity identifier to secure mobile devices...
September 28, 2016: Journal of Medical Engineering & Technology
C Miles Maliska, John Blebea, Kevin E Taubman
A 56-year-old female presented with episodic vertigo, dizziness and diplopia during meals and prolonged verbal presentations at work. Subsequent work-up included an eventual catheter-based-angiogram revealing an ostial left ECA (external carotid artery) occlusion with reconstituted retrograde flow via a variant collateral branch from the dominant left vertebral artery (VA). The findings demonstrate that repetitive activities involving craniofacial muscular systems supplied by the ECA result in a symptomatic arterial steal syndrome via the enhanced diverted flow from the collateral vertebral-basilar arterial system...
September 22, 2016: Annals of Vascular Surgery
Santosh Kumar Sinha, Dibbendhu Khanra, Mukesh Jitendra Jha, Karandeep Singh, Mahamdulla Razi, Amit Goel, Vikas Mishra, Mohammad Asif, Mohit Sachan, Nasar Afdaali, Ashutosh Kumar, Ramesh Thakur, Vinay Krishna, Umeshwar Pandey, Chandra Mohan Varma
ALCAPA syndrome (anomalous origin of the left coronary artery from the pulmonary artery) is a rare disease but lethal with clinical expression from myocardial infarction, congestive heart failure to death during early infancy and unusual survival to adulthood. We report a 73-year-old woman with ALCAPA who presented with exertional dyspnea (NYHA functional class II) over past 2 years. Physical examination revealed soft S, long mid diastolic rumbling murmur and apical pan-systolic murmur. Electrocardiography displayed biatrial enlargement and poor R progression and normal sinus rhythm...
October 2016: Journal of Clinical Medicine Research
Victoria I Holden, Paul Breen, Sébastien Houle, Charles M Dozois, Michael A Bachman
UNLABELLED: Klebsiella pneumoniae is a Gram-negative pathogen responsible for a wide range of infections, including pneumonia and bacteremia, and is rapidly acquiring antibiotic resistance. K. pneumoniae requires secretion of siderophores, low-molecular-weight, high-affinity iron chelators, for bacterial replication and full virulence. The specific combination of siderophores secreted by K. pneumoniae during infection can impact tissue localization, systemic dissemination, and host survival...
2016: MBio
David John Tobias McArdle, David Cottier, Anthony Beasley
No abstract text is available yet for this article.
2016: BMJ Case Reports
Carla Treloar, Luke McCredie, Andrew R Lloyd
AIM: A formal Needle and Syringe Program (NSP) is not provided in Australian prisons. Injecting equipment circulates in prisons as part of an informal and illegal economy. This paper examined how this economy generates blood-borne virus (BBV) risk and risk mitigation opportunities for inmates. METHOD: The HITS-p cohort recruited New South Wales inmates who had reported ever injecting drugs and who had a negative HCV serological test within 12 months prior to enrolment...
2016: PloS One
Wijnand J Stuijfzand, Roel S Driessen, Pieter G Raijmakers, Mischa T Rijnierse, Joren Maeremans, Maurits R Hollander, Adriaan A Lammertsma, Albert C van Rossum, Jo Dens, Alexander Nap, Niels van Royen, Paul Knaapen
AIMS: Previous studies on invasive assessment of collateral function in patients with a chronic total occlusion (CTO) have displayed only a limited increase in collateral flow and high occurrence of coronary steal during pharmacological stress. This could question the necessity for ischaemia testing prior to revascularization of CTOs in the presence of myocardial viability. The purpose of the present study was to determine the prevalence of perfusion impairments in patients with a CTO as assessed by [(15)O]H2O positron emission tomography (PET)...
September 1, 2016: European Heart Journal Cardiovascular Imaging
Rosalind F Roberts, Edward A Fon
In a recent paper published in Cell, Matheoud et al. demonstrated that, in response to cellular stress, self-antigens can be extracted from mitochondria via mitochondrial-derived vesicles and presented at the cell surface to trigger an immune response; this pathway, termed mitochondrial antigen presentation (MitAP), is repressed by PINK1 and Parkin. These findings implicate autoimmune mechanisms in Parkinson's disease.
September 2, 2016: Cell Research
Erin L Mazerolle, Yuhan Ma, David Sinclair, G Bruce Pike
Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) studies of patients with cerebrovascular disease have largely ignored the confounds associated with abnormal cerebral blood flow, vascular reactivity and neurovascular coupling. We studied BOLD fMRI activation and cerebrovascular reactivity in moyamoya disease. To characterize the impact of remote vascular demands on BOLD fMRI measurements, we varied the vascular territories engaged by manipulating the experimental task performed by the participants...
August 30, 2016: Clinical Physiology and Functional Imaging
Leszek Wrotniak, Anna Kabłak-Ziembicka, Agnieszka Rosławiecka, Piotr Musiałek, Paweł Bogacki, Mariusz Trystuła, Krzysztof Żmudka, Tadeusz Przewłocki
OBJECTIVE: A minor part of patients with subclavian or innominate artery occlusive disease (subclavian artery stenosis [SAS]) experience symptoms of vertebrobasilar insufficiency, upper extremity exertional ischemia (UEEI), or cardiac ischemia owing to subclavian-coronary steal (SCS) in some instances. The study aimed to assess the impact of percutaneous transluminal angioplasty (PTA) of symptomatic SAS on symptom resolution and to determine factors related with SAS recurrence. METHODS: Symptom resolution and incidence of restenosis (RS) were evaluated for up to 15 years in patients who had undergone successful PTA of SAS...
September 2016: Journal of Vascular Surgery
Sarah L Gold, Kristen Gilmore Powell, Michael H Eversman, N Andrew Peterson, Suzanne Borys, Donald K Hallcom
OBJECTIVES: To explore the high-risk ways in which older adults obtain prescription opioids and to identify predictors of obtaining prescription opioids from high-risk sources, such as obtaining the same drug from multiple doctors, sharing drugs, and stealing prescription pads. DESIGN: Logistic regression analyses of cross-sectional survey data from the New Jersey Older Adult Survey on Drug Use and Health, a representative random-sample survey. PARTICIPANTS: Adults aged 60 and older (N = 725)...
August 26, 2016: Journal of the American Geriatrics Society
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