keyword
https://read.qxmd.com/read/38536862/ultrastable-iodinated-oil-based-pickering-emulsion-enables-locoregional-sustained-codelivery-of-hypoxia-inducible-factor-1-inhibitor-and-anticancer-drugs-for-tumor-combination-chemotherapy
#1
JOURNAL ARTICLE
Zhihua Li, Xiaoya Liu, Jingyu Xiao, Hang Jiang, Le Ma, Yucheng Luo, Meijuan Wang, Yuwei Zhu, Hongliang Jiang, Hanyang Yao, To Ngai, Qiongyu Guo
Tumor hypoxia-associated drug resistance presents a major challenge for cancer chemotherapy. However, sustained delivery systems with a high loading capability of hypoxia-inducible factor-1 (HIF-1) inhibitors are still limited. Here, we developed an ultrastable iodinated oil-based Pickering emulsion (PE) to achieve locally sustained codelivery of a HIF-1 inhibitor of acriflavine and an anticancer drug of doxorubicin for tumor synergistic chemotherapy. The PE exhibited facile injectability for intratumoral administration, great radiopacity for in vivo examination, excellent physical stability (>1 mo), and long-term sustained release capability of both hydrophilic drugs (i...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38536125/overcoming-solubility-challenges-liposomal-isocoq-carbazole-as-a-promising-anti-tumor-agent-for-inoperable-and-radiation-insensitive-cancers
#2
JOURNAL ARTICLE
Diana Lamaa, Catherine Cailleau, Juliette Vergnaud, Julie Mougin, Jérôme Bignon, Mouad Alami, Elias Fattal, Abdallah Hamze, Nicolas Tsapis
This study evaluated the potential of isoCoQ-Carbazole, a diheterocyclic analog of isoCA-4, as an anti-tumor agent. To overcome its low aqueous solubility, liposomes were developed as a delivery system for the compound. In vitro experiments showed that loaded liposomes exhibited similar activity to the free form on multiple human tumor cell lines. In vivo experiments using a palliative intratumoral injection chemotherapy approach further demonstrated that isoCoQ-Carbazole loaded liposomes significantly reduced tumor growth in a CA-4-resistant HT29 cell model, without inducing any observable toxicity or weight loss in the treated mice...
March 27, 2024: Chembiochem: a European Journal of Chemical Biology
https://read.qxmd.com/read/38533514/single-cell-transcriptome-sequencing-provides-insight-into-multiple-chemotherapy-resistance-in-a-patient-with-refractory-dlbcl-a-case-report
#3
Kewei Zhao, Qiuhui Li, Pengye Li, Tao Liu, Xinxiu Liu, Fang Zhu, Liling Zhang
Relapsed and refractory diffuse large B-cell lymphoma (DLBCL) is associated with poor prognosis. As such, a comprehensive analysis of intratumoral components, intratumoral heterogeneity, and the immune microenvironment is essential to elucidate the mechanisms driving the progression of DLBCL and to develop new therapeutics. Here, we used single-cell transcriptome sequencing and conventional bulk next-generation sequencing (NGS) to understand the composite tumor landscape of a single patient who had experienced multiple tumor recurrences following several chemotherapy treatments...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38524649/intratumoral-metastasis-of-sigmoid-colon-cancer-to-chromophobe-renal-cell-carcinoma-a-case-report
#4
JOURNAL ARTICLE
Suzuna Sakai, Kojiro Ohba, Kazunari Migita, Ichiro Sekine, Yasuto Yamazaki
We herein report an extremely rare case of intratumoral metastasis of colon cancer to chromophobe renal cell carcinoma. A 71-year-old woman was diagnosed with lung metastasis of sigmoid colon cancer and underwent sigmoid colon resection with D3 lymph node dissection. Preoperative contrast-enhanced computed tomography (CT) revealed a left renal tumor; however, colon resection was prioritized, and the renal tumor was placed under observation. Two years later, CT revealed enlargement of the left renal tumor, and laparoscopic partial left nephrectomy was performed 1 month later...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38516246/immune-signature-of-small-bowel-adenocarcinoma-and-the-role-of-tumor-microenvironment
#5
EDITORIAL
Grigorios Christodoulidis, Marina Nektaria Kouliou, Konstantinos Eleftherios Koumarelas
In this editorial we comment on the article published "Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment". Small bowel adenocarcinoma (SBA) is a rare gastrointestinal neoplasm and despite the small intestine's significant surface area, SBA accounts for less than 3% of such tumors. Early detection is challenging and the reason arises from its asymptomatic nature, often leading to late-stage discovery and poor prognosis. Treatment involves platinum-based chemotherapy with a 5-fluorouracil combination, but the lack of effective chemotherapy contributes to a generally poor prognosis...
February 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38515107/factors-associated-with-engraftment-success-of-patient-derived-xenografts-of-breast-cancer
#6
JOURNAL ARTICLE
Jongwon Lee, GunHee Lee, Hye Seon Park, Byung-Kwan Jeong, Gyungyub Gong, Jae Ho Jeong, Hee Jin Lee
BACKGROUND: Patient-derived xenograft (PDX) models serve as a valuable tool for the preclinical evaluation of novel therapies. They closely replicate the genetic, phenotypic, and histopathological characteristics of primary breast tumors. Despite their promise, the rate of successful PDX engraftment is various in the literature. This study aimed to identify the key factors associated with successful PDX engraftment of primary breast cancer. METHODS: We integrated clinicopathological data with morphological attributes quantified using a trained artificial intelligence (AI) model to identify the principal factors affecting PDX engraftment...
March 21, 2024: Breast Cancer Research: BCR
https://read.qxmd.com/read/38512406/predicting-pathological-complete-response-to-neoadjuvant-chemotherapy-in-breast-cancer-patients-use-of-mri-radiomics-data-from-three-regions-with-multiple-machine-learning-algorithms
#7
JOURNAL ARTICLE
Guangying Zheng, Jiaxuan Peng, Zhenyu Shu, Hui Jin, Lu Han, Zhongyu Yuan, Xue Qin, Jie Hou, Xiaodong He, Xiangyang Gong
OBJECTIVE: To construct a multi-region MRI radiomics model for predicting pathological complete response (pCR) in breast cancer (BCa) patients who received neoadjuvant chemotherapy (NACT) and provide a theoretical basis for the peritumoral microenvironment affecting the efficacy of NACT. METHODS: A total of 133 BCa patients who received NACT, including 49 with confirmed pCR, were retrospectively analyzed. The radiomics features of the intratumoral region, peritumoral region, and background parenchymal enhancement (BPE) were extracted, and the most relevant features were obtained after dimensional reduction...
March 21, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38499670/prognostic-implications-of-tumor-histology-and-microenvironment-in-surgically-resected-intrahepatic-cholangiocarcinoma-a-single-institutional-experience
#8
JOURNAL ARTICLE
Irene Y Chen, Richard F Dunne, Xiaoyan Liao
Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignant neoplasm. Certain histologic features and the tumor microenvironment may impact disease progression. We aim to characterize the clinicopathologic features of ICC to identify prognostic factors. A total of 50 surgically resected ICC (partial or transplant) cases were analyzed. The cohort included 26 men and 24 women with a median age of 62 years. Eighteen (36%) cases were multifocal ICC with a mean largest tumor size of 6.5 cm. Neoadjuvant and adjuvant chemotherapy was done in eight (16%) and 33 (66%) patients, respectively...
March 19, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38499669/p53-overexpression-may-represent-an-early-marker-of-clinicopathologic-progression-in-vasculogenic-mesenchymal-lesions-of-germ-cell-tumor-origin
#9
JOURNAL ARTICLE
Reem Youssef, Thomas M Ulbright, Andres M Acosta
Vasculogenic mesenchymal lesions (VMLs) of germ cell tumor origin are thought to originate in postpubertal-type yolk sac tumor components and include a spectrum of lesions from teratoma with vasculogenic stroma (TVS), to low and high-grade vasculogenic mesenchymal tumors (VMTs). VMLs exhibit rudimentary to well-developed neoplastic vessels within primitive mesenchyme, being considered a neoplastic reiteration of embryonic vasculogenesis in the splanchnic mesoderm of the yolk sac. They occur in patients with primary mediastinal germ cell tumors after chemotherapy, and a subset progresses to "somatic-type" sarcomas [including angiosarcoma (AS)], with high-grade VMTs likely portending a higher risk...
March 19, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38497600/biomimetic-nanovehicle-enabled-targeted-depletion-of-intratumoral-fusobacterium-nucleatum-synergizes-with-pd-l1-blockade-against-breast-cancer
#10
JOURNAL ARTICLE
Shizhen Geng, Pengke Guo, Xinling Li, Yaru Shi, Jing Wang, Mengnian Cao, Yunya Zhang, Kaixiang Zhang, Airong Li, Haiwei Song, Zhenzhong Zhang, Jinjin Shi, Junjie Liu, Yiling Yang
Immune checkpoint blockade (ICB) therapy has been approved for breast cancer (BC), but clinical response rates are limited. Recent studies have shown that commensal microbes colonize a variety of tumors and are closely related to the host immune system response. Here, we demonstrated that Fusobacterium nucleatum ( F.n ), which is prevalent in BC, creates an immunosuppressive tumor microenvironment (ITME) characterized by a high-influx of myeloid cells that hinders ICB therapy. Administering the antibiotic metronidazole in BC can deplete F...
March 18, 2024: ACS Nano
https://read.qxmd.com/read/38480932/basal-epithelial-subpopulations-underlie-and-predict-chemotherapy-resistance-in-triple-negative-breast-cancer
#11
JOURNAL ARTICLE
Mohammed Inayatullah, Arun Mahesh, Arran K Turnbull, J Michael Dixon, Rachael Natrajan, Vijay K Tiwari
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, characterized by extensive intratumoral heterogeneity, high metastasis, and chemoresistance, leading to poor clinical outcomes. Despite progress, the mechanistic basis of these aggressive behaviors remains poorly understood. Using single-cell and spatial transcriptome analysis, here we discovered basal epithelial subpopulations located within the stroma that exhibit chemoresistance characteristics. The subpopulations are defined by distinct signature genes that show a frequent gain in copy number and exhibit an activated epithelial-to-mesenchymal transition program...
March 13, 2024: EMBO Molecular Medicine
https://read.qxmd.com/read/38480916/p53-modulates-kinase-inhibitor-resistance-and-lineage-plasticity-in-nf1-related-mpnsts
#12
JOURNAL ARTICLE
Jamie L Grit, Lauren E McGee, Elizabeth A Tovar, Curt J Essenburg, Emily Wolfrum, Ian Beddows, Kaitlin Williams, Rachael T C Sheridan, Joshua L Schipper, Marie Adams, Menusha Arumugam, Thomas Vander Woude, Sharavana Gurunathan, Jeffrey M Field, Julia Wulfkuhle, Emanuel F Petricoin, Carrie R Graveel, Matthew R Steensma
Malignant peripheral nerve sheath tumors (MPNSTs) are chemotherapy resistant sarcomas that are a leading cause of death in neurofibromatosis type 1 (NF1). Although NF1-related MPNSTs derive from neural crest cell origin, they also exhibit intratumoral heterogeneity. TP53 mutations are associated with significantly decreased survival in MPNSTs, however the mechanisms underlying TP53-mediated therapy responses are unclear in the context of NF1-deficiency. We evaluated the role of two commonly altered genes, MET and TP53, in kinome reprograming and cellular differentiation in preclinical MPNST mouse models...
March 13, 2024: Oncogene
https://read.qxmd.com/read/38474542/-177-lu-labeled-iron-oxide-nanoparticles-functionalized-with-doxorubicin-and-bevacizumab-as-nanobrachytherapy-agents-against-breast-cancer
#13
JOURNAL ARTICLE
Evangelia-Alexandra Salvanou, Argiris Kolokithas-Ntoukas, Danai Prokopiou, Maria Theodosiou, Eleni Efthimiadou, Przemysław Koźmiński, Stavros Xanthopoulos, Konstantinos Avgoustakis, Penelope Bouziotis
The use of conventional methods for the treatment of cancer, such as chemotherapy or radiotherapy, and approaches such as brachytherapy in conjunction with the unique properties of nanoparticles could enable the development of novel theranostic agents. The aim of our current study was to evaluate the potential of iron oxide nanoparticles, coated with alginic acid and polyethylene glycol, functionalized with the chemotherapeutic agent doxorubicin and the monoclonal antibody bevacizumab, to serve as a nanoradiopharmaceutical agent against breast cancer...
February 27, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38472332/decoding-gene-regulatory-circuitry-underlying-tnbc-chemoresistance-reveals-biomarkers-for-therapy-response-and-therapeutic-targets
#14
JOURNAL ARTICLE
Ryan Lusby, Ziyi Zhang, Arun Mahesh, Vijay K Tiwari
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype characterised by extensive intratumoral heterogeneity, high rates of metastasis and chemoresistance, leading to poor clinical outcomes. Despite progress, the mechanistic basis of chemotherapy resistance in TNBC patients remains poorly understood. Here, leveraging single-cell transcriptome datasets of matched longitudinal TNBC chemoresponsive and chemoresistant patient cohorts, we unravel distinct cell subpopulations intricately associated with chemoresistance and the signature genes defining these populations...
March 12, 2024: NPJ Precision Oncology
https://read.qxmd.com/read/38468248/prognostic-significance-of-t-lymphocyte-subgroups-cd4-and-cd8-in-lung-cancer-patients-after-neoadjuvant-chemotherapy
#15
JOURNAL ARTICLE
Aykut Elicora, Busra Yaprak Bayrak, Cigdem Vural, Huseyin Fatih Sezer, Semra Uzun Erkal, Elif Metin
OBJECTIVE: The basis for current and future lung cancer immunotherapy depends on our knowledge of molecular mechanisms of interactions between tumor and immune system cells. Interactions that occur between different intratumoral populations of the same cells are important. In our study, we aimed to evaluate relationship between the clinical and prognostic features and T lymphocyte subgroups of patients with lung tumors after neoadjuvant treatment. METHODS: A total of 72 patients were included in our study, including study group, 39 of whom received neoadjuvant chemotherapy...
March 11, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38459600/primary-extraskeletal-intradural-ewing-sarcoma-with-acute-hemorrhage-a-case-report-and-review-of-the%C3%A2-literature
#16
JOURNAL ARTICLE
HusamEddin Salama, Lila H Abu-Hilal, Mayar Idkedek, Abdalwahab Kharousha, Mohand Abulihya, Hafez Nimer
BACKGROUND: Spinal cord tumors present a challenge in diagnosis and treatment due to their varied histopathological characteristics. While Ewing sarcoma is a rare malignant tumor typically originating from skeletal bone, cases of primary intradural extraskeletal Ewing sarcoma are exceptionally rare. The similarity of its presentation to other spinal tumors further complicates its identification and management. CASE PRESENTATION: We report a case of a 58-year-old Palestinian male with intradural extraskeletal lumbar Ewing sarcoma...
March 9, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38458640/an-oncolytic-vaccinia-virus-encoding-hyaluronidase-reshapes-the-extracellular-matrix-to-enhance-cancer-chemotherapy-and-immunotherapy
#17
JOURNAL ARTICLE
Shibing Wang, Yuxin Li, Chuning Xu, Jie Dong, Jiwu Wei
BACKGROUND: The redundant extracellular matrix (ECM) within tumor microenvironment (TME) such as hyaluronic acid (HA) often impairs intratumoral dissemination of antitumor drugs. Oncolytic viruses (OVs) are being studied extensively for cancer therapy either alone or in conjunction with chemotherapy and immunotherapy. Here, we designed a novel recombinant vaccinia virus encoding a soluble version of hyaluronidase Hyal1 (OVV-Hyal1) to degrade the HA and investigated its antitumor effects in combination with chemo drugs, polypeptide, immune cells, and antibodies...
March 7, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38457288/a-phase-ii-open-label-randomized-clinical-trial-of-preoperative-durvalumab-or-durvalumab-plus-tremelimumab-in-resectable-head-and-neck-squamous-cell-carcinoma
#18
JOURNAL ARTICLE
Chang Gon Kim, Min Hee Hong, Dahee Kim, Brian Hyohyoung Lee, Hyunwook Kim, Chan-Young Ock, Geoffrey Kelly, Yoon Ji Bang, Gamin Kim, Jung Eun Lee, Chaeyeon Kim, Se-Heon Kim, Hyun Jun Hong, Young Min Park, Nam Suk Sim, Heejung Park, Jin Woo Park, Chang Geol Lee, Kyung Hwan Kim, Goeun Park, Inkyung Jung, Dawoon Han, Jong Hoon Kim, Junha Cha, Insuk Lee, Mingu Kang, Heon Song, Chiyoon Oum, Seulki Kim, Sukjun Kim, Yoojoo Lim, Seunghee Kim-Schulze, Miriam Merad, Sun Och Yoon, Hyun Je Kim, Yoon Woo Koh, Hye Ryun Kim
PURPOSE: Clinical implications of neoadjuvant immunotherapy in patients with locally advanced but resectable head and neck squamous cell carcinoma (HNSCC) remain largely unexplored. PATIENTS AND METHODS: Patients with resectable HNSCC were randomized to receive a single dose of preoperative durvalumab (D) with or without tremelimumab (T) before resection, followed by postoperative (chemo)radiation based on multidisciplinary discretion and 1-year D treatment. Artificial intelligence (AI)-powered spatial distribution analysis of tumor-infiltrating lymphocytes and high-dimensional profiling of circulating immune cells tracked dynamic intratumoral and systemic immune responses...
March 8, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38442004/multi-omics-analysis-elucidates-the-relationship-between-intratumor-microbiome-and-host-immune-heterogeneity-in-breast-cancer
#19
JOURNAL ARTICLE
Jia Li, Yu Zhang, Yifan Cai, Peizhuo Yao, Yiwei Jia, Xinyu Wei, Chong Du, Shuqun Zhang
Research has indicated that intratumor microbiomes affect the occurrence, progression, and therapeutic response in many cancer types by influencing the immune system. We aim to evaluate the characteristics of immune-related intratumor microbiomes (IRIMs) in breast cancer (BC) and search for potential prognosis prediction factors and treatment targets. The clinical information, microbiome data, transcriptomics data of The Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) patients were obtained from Kraken-TCGA-Raw-Data and TCGA portal...
March 5, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38422657/low-molecular-weight-fucoidan-lf2-improves-the-immunosuppressive-tumor-microenvironment-and-enhances-the-anti-pancreatic-cancer-activity-of-oxaliplatin
#20
JOURNAL ARTICLE
Zhenzhen Deng, Suo Qishan, Quanbin Zhang, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Chemotherapy remains the cornerstone of pancreatic cancer treatment. However, the dense interstitial and immunosuppressive microenvironment frequently render the ineffective anti-tumor activity of chemotherapeutic agents. Macrophages play a key role in the tumor immunomodulation. In this study, we found that low molecular weight of fucoidan (LF2) directly regulated the differentiation of mononuclear macrophages into the CD86+ M1 phenotype. LF2 significantly upregulated the expressions of M1 macrophage-specific cytokines, including iNOS, IL-6, TNFα and IL-12...
February 28, 2024: Biomedicine & Pharmacotherapy
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