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A F Athiyyah, A Darma, R Ranuh, W Riawan, A Endaryanto, F A Rantam, I S Surono, S M Sudarmo
This study investigated the probiotic effect of Lactobacillus plantarum IS-10506 in activating and regenerating leucine-rich repeat-containing G-protein-coupled receptor (Lgr)5- and B lymphoma Moloney murine leukaemia virus insertion region (Bmi)1-expressing intestinal stem cells in rodents following Escherichia coli serotype 055:B5 lipopolysaccharide (LPS) exposure. Male Sprague-Dawley rats (n=64) were randomised into control (KN), LPS (KL), probiotic + LPS (KL-Pr), and sequential probiotic + LPS + probiotic (KPR-7L) groups...
May 4, 2018: Beneficial Microbes
Sri-Hidajati Bs, Sukmawati Basuki, Suhintam Pusarawati, Kusmartisnawati, Lynda Rossyanti, Sri Wijayanti Sulistyowati, Dwi Peni Kartikasari, Heny Arwati, Indah Tantular, Alpha Fardah, Andy Darma, Retno Handajani, Subijanto Marto Soedarmo
Background: Amoebiasis, the cause of dysentery and extra-intestinal abscesses, now becomes second fatal parasitic disease in the world. As routine microscopic diagnosis cannot differentiate causative Entamoeba histolytica from non-pathogenic E. dispar and E. moshkovskii , better diagnosis has to be searched. Materials and Methods: Multiplex single round PCR was tested and compared with results of microscopy of wet preparation on 30 samples of diarrheic stools and extra intestinal lesions from amoebiasis suspected patients...
2018: African Journal of Infectious Diseases
Fehmidah Munir, Stuart J H Biddle, Melanie J Davies, David Dunstan, David Esliger, Laura J Gray, Ben R Jackson, Sophie E O'Connell, Tom Yates, Charlotte L Edwardson
BACKGROUND: Sitting (sedentary behaviour) is widespread among desk-based office workers and a high level of sedentary behaviour is a risk factor for poor health. Reducing workplace sitting time is therefore an important prevention strategy. Interventions are more likely to be effective if they are theory and evidence-based. The Behaviour Change Wheel (BCW) provides a framework for intervention development. This article describes the development of the Stand More AT Work (SMArT Work) intervention, which aims to reduce sitting time among National Health Service (NHS) office-based workers in Leicester, UK...
March 6, 2018: BMC Public Health
Surya Darma, Yusrizal Djam'an Saleh, Tri Wibawa
Talaromycosis, a disseminated and progressive infection caused by Talaromyces marneffei , is highly endemic in the tropical region of Asia. However, accumulated data show very low incidence in Indonesia. Here, we report a case of papillary thyroid carcinoma with pulmonary T. marneffei infection. Screening of T. marneffei in this immunocompromised Indonesian patient is recommended even though the reported incidence of this particular fungal infection in Indonesia is low.
2017: SAGE Open Medical Case Reports
Huong Thi Lan Nguyen, Naksit Panyoyai, Vilia Darma Paramita, Nitin Mantri, Stefan Kasapis
The present work investigated the physicochemical and structural properties of Tulsi, Alfalfa and two varieties of Manuka honey derived from medicinal plants. Chemical analysis yielded data on the content of reducing sugars (glucose and fructose) that dominate the honey matrix, and of the minor constituents of protein, phenols and flavonoids. Standard chemical assays were used to develop a database of water content, electrical conductivity, pH, ash content, visual appearance and colour intensity. Physicochemical characteristics were related to structural behaviour of the four honey types, as recorded by small-deformation dynamic oscillation in shear, micro- and modulated differential scanning calorimetry, wide angle X-ray diffraction and infrared spectroscopy...
February 15, 2018: Food Chemistry
Jeffrey M Girard, Aidan G C Wright
Continuous measurement systems provide a means of measuring dynamic behavioral and experiential processes as they play out over time. DARMA is a modernized continuous measurement system that synchronizes media playback and the continuous recording of two-dimensional measurements. These measurements can be observational or self-reported and are provided in real-time through the manipulation of a computer joystick. DARMA also provides tools for reviewing and comparing collected measurements and for customizing various settings...
June 20, 2017: Behavior Research Methods
Zubairu Darma Umar, Nor Azwady Abd Aziz, Syaizwan Zahmir Zulkifli, Muskhazli Mustafa
Polycyclic Aromatic Hydrocarbons (PAHs) are complex and widely distributed environmental pollutants that can affect living ecosystems. This study was conducted to rapidly degrade phenanthrene and pyrene representing low and high molecular weight of PAHs, respectively. Cronobacter sakazakii MM045 (KT933253) was identified from used engine oil of contaminated soil. PAHs biodegradation was carried out using 2,6-dichlorophenol indophenol (DCPIP) assay. Biodegradation influencing factors including agitation, temperature, pH, inoculums volume and salinity were enhanced using Response Surface Methodology (RSM) by Central Composite Design (CCD)...
2017: MethodsX
Anita Olejek, Iwona Gabriel, Anna Bilska-Janosik, Iwona Kozak-Darmas, Aleksandra Kawczyk-Krupka
BACKGROUND: Lichen sclerosus (LS) is a difficult to treat, often relapsing disease with unknown background. Autoimmune diseases also coexist with LS. Over recent years photodynamic therapy (PDT) has been shown to be a noninvasive and successful therapeutic approach for the effective treatment of many conditions. However, the change of immune status of the patients based on ANA antibodies has not been yet reported. Our aim was to observe the clinical response followed by possible changes in autoimmune antibodies levels before and after PDT for LS...
June 2017: Photodiagnosis and Photodynamic Therapy
Janice Paterson, Joan Ostaszkiewicz, I Gede Putu Darma Suyasa, Jennifer Skelly, Lesley Bellefeuille
Although nurses have specialized in the management of incontinence, bladder, bowel, and pelvic floor dysfunction for more than 30 years, there is a lack of awareness and underutilization of their role. This article describes a 6-year project to define, characterize, and validate a role profile of the Nurse Continence Specialist. Data collection used a 2-phase, mixed-methods design. Phase 1 of the project resulted in a draft Nurse Continence Specialist role profile and Phase 2 led to validation of the draft profile...
November 2016: Journal of Wound, Ostomy, and Continence Nursing
Katsunori Makihara, Takeshi Kato, Yuuki Kabeya, Yusuke Mitsuyuki, Akio Ohta, Daiki Oshima, Satoshi Iwata, Yudi Darma, Mitsuhisa Ikeda, Seiichi Miyazaki
Spin transistors have attracted tremendous interest as new functional devices. However, few studies have investigated enhancements of the ON/OFF current ratio as a function of the electron spin behavior. Here, we found a significantly high spin-dependent current ratio-more than 10(2) at 1.5 V-when changing the relative direction of the magnetizations between FePt nanodots (NDs) and the CoPtCr-coated atomic force microscope (AFM) probe at room temperature. This means that ON and OFF states were achieved by switching the magnetization of the FePt NDs, which can be regarded as spin-diodes...
2016: Scientific Reports
James P Sanders, Adam Loveday, Natalie Pearson, Charlotte Edwardson, Thomas Yates, Stuart J H Biddle, Dale W Esliger
BACKGROUND: It is well documented that meeting the guideline levels (150 minutes per week) of moderate-to-vigorous physical activity (PA) is protective against chronic disease. Conversely, emerging evidence indicates the deleterious effects of prolonged sitting. Therefore, there is a need to change both behaviors. Self-monitoring of behavior is one of the most robust behavior-change techniques available. The growing number of technologies in the consumer electronics sector provides a unique opportunity for individuals to self-monitor their behavior...
May 4, 2016: Journal of Medical Internet Research
Justin Beardsley, Marcel Wolbers, Freddie M Kibengo, Abu-Baker M Ggayi, Anatoli Kamali, Ngo Thi Kim Cuc, Tran Quang Binh, Nguyen Van Vinh Chau, Jeremy Farrar, Laura Merson, Lan Phuong, Guy Thwaites, Nguyen Van Kinh, Pham Thanh Thuy, Wirongrong Chierakul, Suwatthiya Siriboon, Ekkachai Thiansukhon, Satrirat Onsanit, Watthanapong Supphamongkholchaikul, Adrienne K Chan, Robert Heyderman, Edson Mwinjiwa, Joep J van Oosterhout, Darma Imran, Hasan Basri, Mayfong Mayxay, David Dance, Prasith Phimmasone, Sayaphet Rattanavong, David G Lalloo, Jeremy N Day
BACKGROUND: Cryptococcal meningitis associated with human immunodeficiency virus (HIV) infection causes more than 600,000 deaths each year worldwide. Treatment has changed little in 20 years, and there are no imminent new anticryptococcal agents. The use of adjuvant glucocorticoids reduces mortality among patients with other forms of meningitis in some populations, but their use is untested in patients with cryptococcal meningitis. METHODS: In this double-blind, randomized, placebo-controlled trial, we recruited adult patients with HIV-associated cryptococcal meningitis in Vietnam, Thailand, Indonesia, Laos, Uganda, and Malawi...
February 11, 2016: New England Journal of Medicine
Meng Zhao, Michel Bosman, Mohammad Danesh, Minggang Zeng, Peng Song, Yudi Darma, Andrivo Rusydi, Hsin Lin, Cheng-Wei Qiu, Kian Ping Loh
Searching for new plasmonic building blocks which offer tunability and design flexibility beyond noble metals is crucial for advancing the field of plasmonics. Herein, we report that solution-synthesized hexagonal Bi2Te3 nanoplates, in the absence of grating configurations, can exhibit multiple plasmon modes covering the entire visible range, as observed by transmission electron microscopy (TEM)-based electron energy-loss spectroscopy (EELS) and cathodoluminescence (CL) spectroscopy. Moreover, different plasmon modes are observed in the center and edge of the single Bi2Te3 nanoplate and a breathing mode is discovered for the first time in a non-noble metal...
December 9, 2015: Nano Letters
Sotirios Nedios, Angeliki Darma, Chiara Stevanello, Sergio Richter, Michael Doering, Sascha Rolf, Philipp Sommer, Gerhard Hindricks, Andreas Bollmann, Arash Arya
BACKGROUND: The modern era of cardiology has changed the population of implantable cardioverter-defibrillator (ICD) recipients. Identifying predictors of electrical storm (ES) in contemporary ICD patients could improve risk stratification, therapeutic strategies, and mortality. OBJECTIVE: The purpose of this study was to address these points in a real-world setting. METHODS: In 330 consecutive patients (65 ± 11 years, 81% male, left ventricular ejection fraction 29% ± 9%) with ICD implanted because of ischemic (n, 204) or nonischemic dilated cardiomyopathy (n, 126), we analyzed the prevalence, predictors, and outcome of ES (≥3 separate VT/VF episodes within 24 hours) therapy...
December 2015: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Li-hua Zheng, Xiao-jiang Hao, Chun-mao Yuan, Lie-jun Huang, Jian-xin Zhang, Fen Dong, Tian-yun Fan, Gui-hui Wu, Yan Chen, Yuan Ma, Yi-min Fan, Wei Gu
Column chromatographies over silica gel, Sephadex LH-20, reverse phase C18, and MCI, and semi-preparative HPLC were used for separation and purification of constituents from Inula cappa. The 22 compounds were obtained and their strutures were determined by NMR and MS spectra data as nine flavonoids: luteolin (1), apigenin (2), chrysoeriol (3), artemetin (4), 2', 5-di- hydroxy-3, 6, 7, 4', 5'-pentamethoxyflavone (5), chrysosplenol C (6), apigenin-5-0-β-D-glucopyranoside (7), luteolin-3-methyl, luteolin-3-methylether-4'-0-β-D-glucopyranoside (8), luteolin-4'-0-β-D-glucopyranoside (9); four triterpenes: darma-20, 24-dien- 3β-0-acetate (10), darma-20, 24-dien-3β-ol (11), epirfiedelanol (12), friedelin (13); three coumarins: scopoletin (14) , isosco- poletin (15) , scopolin(16) , and other types of compounds stigmasta-5, 22-dien-3β-0-7-one (17), stigmasterol (18), palmitic acid (19), linoleic acid (20), linoleic acid methyl ester (21), (E) -9, 12, 13-trihydroxyoetadee-10-enoie acid (22)...
February 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Angeliki Darma, Sotirios Nedios, Jedrzej Kosiuk, Sergio Richter, Michael Doering, Arash Arya, Sascha Rolf, Philipp Sommer, Gerhard Hindricks, Andreas Bollmann
AIMS: Implantable cardioverter-defibrillators (ICDs) have been shown to reduce mortality in patients with both ischaemic and non-ischaemic cardiomyopathy by terminating life-threatening arrhythmias. However, such arrhythmic events are unequally distributed among different patient subgroups. We aimed to evaluate predictors of appropriate ICD therapies as a step towards risk stratification in a real-world cohort. METHODS AND RESULTS: The prevalence and predictors of appropriate ICD therapies were analysed in 330 consecutive patients (mean age 65 ± 11, 81% male) with implanted ICDs due to ischaemic (n = 204) or dilated (n = 126) cardiomyopathy...
March 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Vilia Darma Paramita, Anna Bannikova, Stefan Kasapis
A high-solid matrix of κ-carrageenan with polydextrose was developed to entrap α-linolenic acid, which is an omega-3 bioactive compound. Physicochemical analysis of this system utilised modulated DSC, dynamic oscillation in shear, ESEM, FTIR and WAX diffraction. The carbohydrate matrix was conditioned through an extensive temperature range to induce changes in molecular morphology and identify the network glass transition temperature. Thermally induced variation in phase morphology was employed to rationalise transportation patterns of the bioactive compound within the high-solid preparation...
August 1, 2015: Carbohydrate Polymers
Subijanto Marto Sudarmo, Katsumi Shigemura, Alpha Fardah Athiyyah, Kayo Osawa, Oktavian Prasetia Wardana, Andy Darma, Reza Ranuh, Dadik Raharjo, Soichi Arakawa, Masato Fujisawa, Toshiro Shirakawa
BACKGROUND: Rotavirus infections are a major cause of diarrhea in children in both developed and developing countries. Rotavirus genetics, patient immunity, and environmental factors are thought to be related to the severity of acute diarrhea due to rotavirus in infants and young children. The objective of this study was to provide a correlation between rotavirus genotypes, clinical factors and degree of severity of acute diarrhea in children under 5 years old in Surabaya, Indonesia...
2015: Gut Pathogens
Stanley Darma, Pauline H B Kok, Thomas J T P van den Berg, Michael D Abràmoff, Dirk J Faber, Caroline A Hulsman, Frank Zantvoord, Maarten P Mourits, Reinier O Schlingemann, Frank D Verbraak
PURPOSE: To assess the effect of media opacities on thickness measurements of the peripapillary retinal nerve fibre layer (pRNFL) and macular inner retinal layer (mIRL) performed with spectral-domain optical coherence tomography (SD-OCT) using a set of filters with known optical density. METHODS: Spectral-domain optical coherence tomography volume scans of the optic disc and the macular area were performed in 18 healthy volunteers, using Topcon-3DOCT-1000 Mark II...
June 2015: Acta Ophthalmologica
Jeremy Day, Darma Imran, Ahmed Rizal Ganiem, Natriana Tjahjani, Retno Wahyuningsih, Robiatul Adawiyah, David Dance, Mayfong Mayxay, Paul Newton, Rattanaphone Phetsouvanh, Sayaphet Rattanavong, Adrienne K Chan, Robert Heyderman, Joep J van Oosterhout, Wirongrong Chierakul, Nick Day, Anatoli Kamali, Freddie Kibengo, Eugene Ruzagira, Alastair Gray, David G Lalloo, Justin Beardsley, Tran Quang Binh, Tran Thi Hong Chau, Nguyen Van Vinh Chau, Ngo Thi Kim Cuc, Jeremy Farrar, Tran Tinh Hien, Nguyen Van Kinh, Laura Merson, Lan Phuong, Loc Truong Tho, Pham Thanh Thuy, Guy Thwaites, Heiman Wertheim, Marcel Wolbers
BACKGROUND: Cryptococcal meningitis (CM) is a severe AIDS-defining illness with 90-day case mortality as high as 70% in sub-Saharan Africa, despite treatment. It is the leading cause of death in HIV patients in Asia and Africa.No major advance has been made in the treatment of CM since the 1970s. The mainstays of induction therapy are amphotericin B and flucytosine, but these are often poorly available where the disease burden is highest. Adjunctive treatments, such as dexamethasone, have had dramatic effects on mortality in other neurologic infections, but are untested in CM...
November 12, 2014: Trials
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