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Katsunori Makihara, Takeshi Kato, Yuuki Kabeya, Yusuke Mitsuyuki, Akio Ohta, Daiki Oshima, Satoshi Iwata, Yudi Darma, Mitsuhisa Ikeda, Seiichi Miyazaki
Spin transistors have attracted tremendous interest as new functional devices. However, few studies have investigated enhancements of the ON/OFF current ratio as a function of the electron spin behavior. Here, we found a significantly high spin-dependent current ratio-more than 10(2) at 1.5 V-when changing the relative direction of the magnetizations between FePt nanodots (NDs) and the CoPtCr-coated atomic force microscope (AFM) probe at room temperature. This means that ON and OFF states were achieved by switching the magnetization of the FePt NDs, which can be regarded as spin-diodes...
2016: Scientific Reports
James P Sanders, Adam Loveday, Natalie Pearson, Charlotte Edwardson, Thomas Yates, Stuart J H Biddle, Dale W Esliger
BACKGROUND: It is well documented that meeting the guideline levels (150 minutes per week) of moderate-to-vigorous physical activity (PA) is protective against chronic disease. Conversely, emerging evidence indicates the deleterious effects of prolonged sitting. Therefore, there is a need to change both behaviors. Self-monitoring of behavior is one of the most robust behavior-change techniques available. The growing number of technologies in the consumer electronics sector provides a unique opportunity for individuals to self-monitor their behavior...
2016: Journal of Medical Internet Research
Justin Beardsley, Marcel Wolbers, Freddie M Kibengo, Abu-Baker M Ggayi, Anatoli Kamali, Ngo Thi Kim Cuc, Tran Quang Binh, Nguyen Van Vinh Chau, Jeremy Farrar, Laura Merson, Lan Phuong, Guy Thwaites, Nguyen Van Kinh, Pham Thanh Thuy, Wirongrong Chierakul, Suwatthiya Siriboon, Ekkachai Thiansukhon, Satrirat Onsanit, Watthanapong Supphamongkholchaikul, Adrienne K Chan, Robert Heyderman, Edson Mwinjiwa, Joep J van Oosterhout, Darma Imran, Hasan Basri, Mayfong Mayxay, David Dance, Prasith Phimmasone, Sayaphet Rattanavong, David G Lalloo, Jeremy N Day
BACKGROUND: Cryptococcal meningitis associated with human immunodeficiency virus (HIV) infection causes more than 600,000 deaths each year worldwide. Treatment has changed little in 20 years, and there are no imminent new anticryptococcal agents. The use of adjuvant glucocorticoids reduces mortality among patients with other forms of meningitis in some populations, but their use is untested in patients with cryptococcal meningitis. METHODS: In this double-blind, randomized, placebo-controlled trial, we recruited adult patients with HIV-associated cryptococcal meningitis in Vietnam, Thailand, Indonesia, Laos, Uganda, and Malawi...
February 11, 2016: New England Journal of Medicine
Meng Zhao, Michel Bosman, Mohammad Danesh, Minggang Zeng, Peng Song, Yudi Darma, Andrivo Rusydi, Hsin Lin, Cheng-Wei Qiu, Kian Ping Loh
Searching for new plasmonic building blocks which offer tunability and design flexibility beyond noble metals is crucial for advancing the field of plasmonics. Herein, we report that solution-synthesized hexagonal Bi2Te3 nanoplates, in the absence of grating configurations, can exhibit multiple plasmon modes covering the entire visible range, as observed by transmission electron microscopy (TEM)-based electron energy-loss spectroscopy (EELS) and cathodoluminescence (CL) spectroscopy. Moreover, different plasmon modes are observed in the center and edge of the single Bi2Te3 nanoplate and a breathing mode is discovered for the first time in a non-noble metal...
December 9, 2015: Nano Letters
Sotirios Nedios, Angeliki Darma, Chiara Stevanello, Sergio Richter, Michael Doering, Sascha Rolf, Philipp Sommer, Gerhard Hindricks, Andreas Bollmann, Arash Arya
BACKGROUND: The modern era of cardiology has changed the population of implantable cardioverter-defibrillator (ICD) recipients. Identifying predictors of electrical storm (ES) in contemporary ICD patients could improve risk stratification, therapeutic strategies, and mortality. OBJECTIVE: The purpose of this study was to address these points in a real-world setting. METHODS: In 330 consecutive patients (65 ± 11 years, 81% male, left ventricular ejection fraction 29% ± 9%) with ICD implanted because of ischemic (n, 204) or nonischemic dilated cardiomyopathy (n, 126), we analyzed the prevalence, predictors, and outcome of ES (≥3 separate VT/VF episodes within 24 hours) therapy...
December 2015: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Li-hua Zheng, Xiao-jiang Hao, Chun-mao Yuan, Lie-jun Huang, Jian-xin Zhang, Fen Dong, Tian-yun Fan, Gui-hui Wu, Yan Chen, Yuan Ma, Yi-min Fan, Wei Gu
Column chromatographies over silica gel, Sephadex LH-20, reverse phase C18, and MCI, and semi-preparative HPLC were used for separation and purification of constituents from Inula cappa. The 22 compounds were obtained and their strutures were determined by NMR and MS spectra data as nine flavonoids: luteolin (1), apigenin (2), chrysoeriol (3), artemetin (4), 2', 5-di- hydroxy-3, 6, 7, 4', 5'-pentamethoxyflavone (5), chrysosplenol C (6), apigenin-5-0-β-D-glucopyranoside (7), luteolin-3-methyl, luteolin-3-methylether-4'-0-β-D-glucopyranoside (8), luteolin-4'-0-β-D-glucopyranoside (9); four triterpenes: darma-20, 24-dien- 3β-0-acetate (10), darma-20, 24-dien-3β-ol (11), epirfiedelanol (12), friedelin (13); three coumarins: scopoletin (14) , isosco- poletin (15) , scopolin(16) , and other types of compounds stigmasta-5, 22-dien-3β-0-7-one (17), stigmasterol (18), palmitic acid (19), linoleic acid (20), linoleic acid methyl ester (21), (E) -9, 12, 13-trihydroxyoetadee-10-enoie acid (22)...
February 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Angeliki Darma, Sotirios Nedios, Jedrzej Kosiuk, Sergio Richter, Michael Doering, Arash Arya, Sascha Rolf, Philipp Sommer, Gerhard Hindricks, Andreas Bollmann
AIMS: Implantable cardioverter-defibrillators (ICDs) have been shown to reduce mortality in patients with both ischaemic and non-ischaemic cardiomyopathy by terminating life-threatening arrhythmias. However, such arrhythmic events are unequally distributed among different patient subgroups. We aimed to evaluate predictors of appropriate ICD therapies as a step towards risk stratification in a real-world cohort. METHODS AND RESULTS: The prevalence and predictors of appropriate ICD therapies were analysed in 330 consecutive patients (mean age 65 ± 11, 81% male) with implanted ICDs due to ischaemic (n = 204) or dilated (n = 126) cardiomyopathy...
March 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Vilia Darma Paramita, Anna Bannikova, Stefan Kasapis
A high-solid matrix of κ-carrageenan with polydextrose was developed to entrap α-linolenic acid, which is an omega-3 bioactive compound. Physicochemical analysis of this system utilised modulated DSC, dynamic oscillation in shear, ESEM, FTIR and WAX diffraction. The carbohydrate matrix was conditioned through an extensive temperature range to induce changes in molecular morphology and identify the network glass transition temperature. Thermally induced variation in phase morphology was employed to rationalise transportation patterns of the bioactive compound within the high-solid preparation...
August 1, 2015: Carbohydrate Polymers
Subijanto Marto Sudarmo, Katsumi Shigemura, Alpha Fardah Athiyyah, Kayo Osawa, Oktavian Prasetia Wardana, Andy Darma, Reza Ranuh, Dadik Raharjo, Soichi Arakawa, Masato Fujisawa, Toshiro Shirakawa
BACKGROUND: Rotavirus infections are a major cause of diarrhea in children in both developed and developing countries. Rotavirus genetics, patient immunity, and environmental factors are thought to be related to the severity of acute diarrhea due to rotavirus in infants and young children. The objective of this study was to provide a correlation between rotavirus genotypes, clinical factors and degree of severity of acute diarrhea in children under 5 years old in Surabaya, Indonesia...
2015: Gut Pathogens
Stanley Darma, Pauline H B Kok, Thomas J T P van den Berg, Michael D Abràmoff, Dirk J Faber, Caroline A Hulsman, Frank Zantvoord, Maarten P Mourits, Reinier O Schlingemann, Frank D Verbraak
PURPOSE: To assess the effect of media opacities on thickness measurements of the peripapillary retinal nerve fibre layer (pRNFL) and macular inner retinal layer (mIRL) performed with spectral-domain optical coherence tomography (SD-OCT) using a set of filters with known optical density. METHODS: Spectral-domain optical coherence tomography volume scans of the optic disc and the macular area were performed in 18 healthy volunteers, using Topcon-3DOCT-1000 Mark II...
June 2015: Acta Ophthalmologica
Jeremy Day, Darma Imran, Ahmed Rizal Ganiem, Natriana Tjahjani, Retno Wahyuningsih, Robiatul Adawiyah, David Dance, Mayfong Mayxay, Paul Newton, Rattanaphone Phetsouvanh, Sayaphet Rattanavong, Adrienne K Chan, Robert Heyderman, Joep J van Oosterhout, Wirongrong Chierakul, Nick Day, Anatoli Kamali, Freddie Kibengo, Eugene Ruzagira, Alastair Gray, David G Lalloo, Justin Beardsley, Tran Quang Binh, Tran Thi Hong Chau, Nguyen Van Vinh Chau, Ngo Thi Kim Cuc, Jeremy Farrar, Tran Tinh Hien, Nguyen Van Kinh, Laura Merson, Lan Phuong, Loc Truong Tho, Pham Thanh Thuy, Guy Thwaites, Heiman Wertheim, Marcel Wolbers
BACKGROUND: Cryptococcal meningitis (CM) is a severe AIDS-defining illness with 90-day case mortality as high as 70% in sub-Saharan Africa, despite treatment. It is the leading cause of death in HIV patients in Asia and Africa.No major advance has been made in the treatment of CM since the 1970s. The mainstays of induction therapy are amphotericin B and flucytosine, but these are often poorly available where the disease burden is highest. Adjunctive treatments, such as dexamethasone, have had dramatic effects on mortality in other neurologic infections, but are untested in CM...
2014: Trials
Jedrzej Kosiuk, Emmanuel Koutalas, Michael Doering, Sotirios Nedios, Philipp Sommer, Sascha Rolf, Angeliki Darma, Ole A Breithardt, Borislav Dinov, Gerhard Hindricks, Sergio Richter, Andreas Bollmann
BACKGROUND: The incidence of postoperative complications following pacemaker or implantable cardioverter-defibrillator implantations in patients treated with new oral anticoagulation agents has not been studied. Here we present a first comparison of complications after cardiac rhythm device (CRD) implantations in patients with atrial fibrillation (AF) treated with dabigatran or uninterrupted warfarin. METHODS AND RESULTS: Using a case-control study design, we compared complications within 30 days after 236 CRD procedures performed under uninterrupted warfarin (n=118) or interrupted dabigatran (n=118)...
2014: Circulation Journal: Official Journal of the Japanese Circulation Society
Jedrzej Kosiuk, Emmanuel Koutalas, Michael Doering, Sotirios Nedios, Philipp Sommer, Sascha Rolf, Angeliki Darma, Ole A Breithardt, Borislav Dinov, Gerhard Hindricks, Sergio Richter, Andreas Bollmann
Background:The incidence of postoperative complications following pacemaker or implantable cardioverter-defibrillator implantations in patients treated with new oral anticoagulation agents has not been studied. Here we present a first comparison of complications after cardiac rhythm device (CRD) implantations in patients with atrial fibrillation (AF) treated with dabigatran or uninterrupted warfarin.Methods and Results:Using a case-control study design, we compared complications within 30 days after 236 CRD procedures performed under uninterrupted warfarin (n=118) or interrupted dabigatran (n=118)...
August 22, 2014: Circulation Journal: Official Journal of the Japanese Circulation Society
Andreas Müssigbrodt, Jedrzej Kosiuk, Emmanuel Koutalas, Sokrates Pastromas, Nikolas Dagres, Angeliki Darma, Johannes Lucas, Ole Alexander Breithardt, Philipp Sommer, Borislav Dinov, Charlotte Eitel, Sascha Rolf, Michael Döring, Sergio Richter, Arash Arya, Daniela Husser, Andreas Bollmann, Gerhard Hindricks
BACKGROUND AND PURPOSE: Approximately 20-25% of the patients with hypertrophic cardiomyopathy (HCM) develop atrial fibrillation (AF) during the clinical course of the disease, a percentage significantly larger than that of the general population. The purpose of the present study was to report on the procedural results of patients with AF and either primary or secondary left ventricular hypertrophy (LVH). METHODS AND SUBJECTS: Twenty-two consecutive HCM patients (55% male, mean age 57±8 years) with symptomatic AF, having undergone AF ablation procedures between September 2009 and July 2012 were compared with respect to procedural outcome and follow-up characteristics with 22 matched controls with secondary cardiac hypertrophy (64% male, 63±10 years) from our prospective AF catheter ablation registry...
June 2015: Journal of Cardiology
Tomasz Biniszkiewicz, Anita Olejek, Iwona Kozak-Darmas, Aleksander Sieroń
BACKGROUND: Lichen sclerosus (LS) is a rarely diagnosed, chronic inflammatory skin and mucosal condition. Its therapy is difficult and frequently not satisfactory. The data on photodynamic therapy (PDT) of vulva are promising but scanty. The aim of our study was to evaluate the therapeutic efficacy of photodynamic therapy in genital LS in women. METHODS: Twenty-four patients with clinical and histopathological diagnosis of lichen sclerosus accompanied with chronic vulvar itching, lasting between 3 months and 11 years, with human papillomavirus (HPV), bacterial and mycotic infections excluded, received three to six PDT cycles (180J, 700mW/cm(2)) in 14 days long intervals...
June 2005: Photodiagnosis and Photodynamic Therapy
I Gede Putu Darma Suyasa, Lily Dongxia Xiao, Penelope Ann Lynn, Pawel Piotr Skuza, Jan Paterson
AIM: To explore the prevalence rate of faecal incontinence in community-dwelling older people, associated factors, impact on quality of life and practices in managing faecal incontinence. METHOD: Using a cross-sectional design, 600 older people aged 60+ were randomly selected from a population of 2916 in Bali, Indonesia using a simple random sampling technique. Three hundred and three participants were interviewed (response rate 51%). RESULTS: The prevalence of faecal incontinence was 22...
June 2015: Australasian Journal on Ageing
Jedrzej Kosiuk, Sotirios Nedios, Angeliki Darma, Sascha Rolf, Sergio Richter, Arash Arya, Christopher Piorkowski, Thomas Gaspar, Philipp Sommer, Daniela Husser, Gerhard Hindricks, Andreas Bollmann
AIMS: Atrial fibrillation (AF) is associated with frequent appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapies. Catheter ablation of AF has been shown to reduce AF burden and improve left ventricular function in heart failure patients but the impact on ICD therapies has not yet been studied. The aim of this study was to test the hypothesis that AF ablation reduces ICD therapies in patients with cardiomyopathies. METHODS AND RESULTS: In 73 consecutive patients (mean age 59 ± 10 years, 85% male) with previously implanted ICD due to ischaemic (n = 30) or dilated cardiomyopathy (n = 43) undergoing AF ablation, the prevalence and frequency of ICD therapies before and after AF ablation were compared...
September 2014: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
I Wayan Gede Artawan Eka Putra, Ni Wayan Arya Utami, I Ketut Suarjana, I Made Kerta Duana, Cok Istri Darma Astiti, I W Putra, Ari Probandari, Edine W Tiemersma, Chatarina Umbul Wahyuni
BACKGROUND: The contrast between the low proportion of tuberculosis (TB) suspects referred from private practitioners in Bali province and the high volume of TB suspects seeking care at private practices suggests problems with TB suspect referral from private practitioners to the public health sector. We aimed to identify key factors associated with the referral of TB suspects by private practitioners. METHODS: We conducted a case-control study conducted in Bali province, Indonesia...
2013: BMC Health Services Research
Bärbel Krause, Susan Darma, Marthe Kaufholz, Stefan Mangold, Stephen Doyle, Sven Ulrich, Harald Leiste, Michael Stüber, Tilo Baumbach
V-Al-C-N hard coatings with high carbon content were deposited by reactive radio-frequency magnetron sputtering using an experimental combinatorial approach, deposition from a segmented sputter target. The composition-dependent coexisting phases within the coating were analysed using the complementary methods of X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES) and extended X-ray absorption fine-structure spectroscopy (EXAFS). For the analysis of the X-ray absorption near-edge spectra, a new approach for evaluation of the pre-edge peak was developed, taking into account the self-absorption effects in thin films...
August 1, 2013: Journal of Applied Crystallography
Kantarawee Khayhan, Ferry Hagen, Weihua Pan, Sitali Simwami, Matthew C Fisher, Retno Wahyuningsih, Arunaloke Chakrabarti, Anuradha Chowdhary, Reiko Ikeda, Saad J Taj-Aldeen, Ziauddin Khan, Margaret Ip, Darma Imran, Ridhawati Sjam, Pojana Sriburee, Wanqing Liao, Kunyaluk Chaicumpar, Varaporn Vuddhakul, Wieland Meyer, Luciana Trilles, Leo J J van Iersel, Jacques F Meis, Corné H W Klaassen, Teun Boekhout
Cryptococcosis is an important fungal disease in Asia with an estimated 140,000 new infections annually the majority of which occurs in patients suffering from HIV/AIDS. Cryptococcus neoformans variety grubii (serotype A) is the major causative agent of this disease. In the present study, multilocus sequence typing (MLST) using the ISHAM MLST consensus scheme for the C. neoformans/C. gattii species complex was used to analyse nucleotide polymorphisms among 476 isolates of this pathogen obtained from 8 Asian countries...
2013: PloS One
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