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JOURNAL ARTICLE
Erin Ziegler, Toni Slotnes-O'Brien, Micah D J Peters
OBJECTIVES: This discussion paper presents recent evidence regarding cancer screening and prevention among the transgender and gender diverse (TGD) community and highlights where and how advanced practice nurses (APNs), particularly those in primary care, can better contribute to closing the gap between healthcare disparities between TGD and cisgendered populations. METHODS: Relevant publications on the topic and professional guidelines and evidence have formed the basis for this discussion paper...
April 14, 2024: Seminars in Oncology Nursing
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JOURNAL ARTICLE
Thibault Mahévas, Amélie Osio, Lise Larcher, Emmanuelle Clappier, Werner Kempf, Lionel Adès, Pierre Fenaux, Marie Sébert, Jérémie Delaleu, Marie Jachiet, Florence Cordoliani, Estelle Charvet, Olivier Carpentier, Raphaël A Itzykson, Marie Weinborn, Nicoleta Mardare, Joséfina Marco-Bonnet, Adèle de Masson, Nicolas Duployez, Tony Huynh, Jean-David Bouaziz, Marie-Dominique Vignon-Pennamen, Maxime Battistella
No abstract text is available yet for this article.
April 12, 2024: Blood Advances
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JOURNAL ARTICLE
Tony Silveira, Mateus Kütter, Bruna Nornberg, Marcela Meirelles, Dennis Silva, Andrea Idelette López, Andressa Lopes, Caroline Castro, Jenifer Moraes, Lucia Emanueli Schimith, Priscila de Leon, Luis Fernando Marins, Mariana Remião
Currently, in Brazil, all researchers involved in animal experimentation must undergo training in laboratory animal science to stay updated on biology, methodology, ethics, and legal considerations related to the use of animals. The training program presented in this study not only aims to fulfill a legal obligation but also intends to train students and professionals to effectively care for their biomodels. It seeks to help them understand the importance of this care, both for the welfare of the animals and for the results of their projects...
April 2024: Zebrafish
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JOURNAL ARTICLE
Theresa Pörschmann, Toni Meier, Stefan Lorkowski
This study aimed to estimate the association between single dietary risk factors and cardiovascular diseases (CVDs) in the WHO European Region (WHO ER) by age and sex using the data of the Global Burden of Diseases Study (GBD) from 1990 to 2019. For this purpose, 13 dietary risks and 13 forms of CVDs were included in the study, and the comparative risk assessment framework of the GBD was used to estimate the deaths attributable to them. The study included four regions, with a total of 54 countries. In 2019, 1...
April 15, 2024: European Journal of Preventive Cardiology
#25
JOURNAL ARTICLE
Simon Leclerc, Alka Gupta, Visa Ruokolainen, Jian-Hua Chen, Kari Kunnas, Axel A Ekman, Henri Niskanen, Ilya Belevich, Helena Vihinen, Paula Turkki, Ana J Perez-Berna, Sergey Kapishnikov, Elina Mäntylä, Maria Harkiolaki, Eric Dufour, Vesa Hytönen, Eva Pereiro, Tony McEnroe, Kenneth Fahy, Minna U Kaikkonen, Eija Jokitalo, Carolyn A Larabell, Venera Weinhardt, Salla Mattola, Vesa Aho, Maija Vihinen-Ranta
Viruses target mitochondria to promote their replication, and infection-induced stress during the progression of infection leads to the regulation of antiviral defenses and mitochondrial metabolism which are opposed by counteracting viral factors. The precise structural and functional changes that underlie how mitochondria react to the infection remain largely unclear. Here we show extensive transcriptional remodeling of protein-encoding host genes involved in the respiratory chain, apoptosis, and structural organization of mitochondria as herpes simplex virus type 1 lytic infection proceeds from early to late stages of infection...
April 15, 2024: PLoS Pathogens
#26
JOURNAL ARTICLE
Julie M Minde, Andrea K Gerlak, Tony Colella, Anna M Murveit
Geospatial online participatory tools, or geo-OPTs, are increasingly used worldwide for engaging the public in planning. Yet, despite growth in the adoption and use of geo-OPTs, and the growing scholarship to accompany it, our understanding of their ability to support public participation in environmental planning is still underdeveloped. In this paper, we investigate the application of a geo-OPT by the United States Army Corps of Engineers (USACE), a leading water management agency in the United States, in three contextually and geographically diverse cases...
April 15, 2024: Environmental Management
#27
JOURNAL ARTICLE
Laura Kärnä, Antti P Launonen, Toni Luokkala, Aleksi Reito
BACKGROUND AND OBJECTIVE: The purpose of our study was to evaluate whether routine follow-up radiographs after distal radius fracture (DRF) treated with volar locking plate (VLP) influenced clinical decision-making and treatment in working-aged patients (18-65 years). We evaluated the possible correlation between clinical status and problems with follow-up radiographs and analyzed the overall reoperation rate. METHODS: The study population of this retrospective cohort study consisted of working-aged (18-65 years) patients with DRF who were treated with VLP between January 2010 and December 2020...
April 15, 2024: Scandinavian Journal of Surgery: SJS
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JOURNAL ARTICLE
Tobias Suske, Helena Sorger, Gabriele Manhart, Frank Ruge, Nicole Prutsch, Mark W Zimmerman, Thomas Eder, Diaaeldin I Abdallah, Barbara Maurer, Christina Wagner, Susann Schönefeldt, Katrin Spirk, Alexander Pichler, Tea Pemovska, Carmen Schweicker, Daniel Pölöske, Emina Hubanic, Dennis Jungherz, Tony Andreas Müller, Myint Myat Khine Aung, Anna Orlova, Ha Thi Thanh Pham, Kerstin Zimmel, Thomas Krausgruber, Christoph Bock, Mathias Müller, Maik Dahlhoff, Auke Boersma, Thomas Rülicke, Roman Fleck, Elvin Dominic de Araujo, Patrick Thomas Gunning, Tero Aittokallio, Satu Mustjoki, Takaomi Sanda, Sylvia Hartmann, Florian Grebien, Gregor Hoermann, Torsten Haferlach, Philipp Bernhard Staber, Heidi Anne Neubauer, Alfred Thomas Look, Marco Herling, Richard Moriggl
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive immature T cell cancer. Mutations in IL7R have been analyzed genetically, but downstream effector functions such as STAT5A and STAT5B hyperactivation are poorly understood. Here, we studied the most frequent and clinically challenging STAT5BN642H driver in T cell development and immature T cell cancer onset and compared it with STAT5A hyperactive variants in transgenic mice. Enhanced STAT5 activity caused disrupted T cell development and promoted an early T cell progenitor-ALL phenotype, with upregulation of genes involved in T cell receptor (TCR) signaling, even in absence of surface TCR...
April 15, 2024: Journal of Clinical Investigation
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JOURNAL ARTICLE
Joseph O'Connor, Tony Weir, Elissa Freer, Brett Kerr
OBJECTIVE: : This retrospective cohort study aimed to assess and compare the accuracy of 3 different Invisalign® treatment regimens in terms of variations of aligner change frequency and type of aligner material in achieving maxillary dental buccal expansion. METHODS: : Altogether, 120 adult patients whose treatment involved maxillary dental expansion with Invisalign® were included. The patients were divided into 3 groups, with each group comprising 40 patients as follows: SmartTrack® 1-week changes (ST1), SmartTrack® 2-week changes (ST2), and EX30® 2-week changes (EX2)...
April 15, 2024: Korean Journal of Orthodontics
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JOURNAL ARTICLE
Kara Goodkey, Anita Wischmeijer, Laurence Perrin, Adrianne E S Watson, Leenah Qureshi, Duccio Maria Cordelli, Francesco Toni, Maria Gnazzo, Francesco Benedicenti, Monique Elmaleh-Bergès, Karen J Low, Anastassia Voronova
ANKRD11 (ankyrin repeat domain 11) is a chromatin regulator and the only gene associated with KBG syndrome, a rare neurodevelopmental disorder. We have previously shown that Ankrd11 regulates murine embryonic cortical neurogenesis. Here, we show a novel olfactory bulb phenotype in a KBG syndrome mouse model and two diagnosed patients. Conditional knockout of Ankrd11 in murine embryonic neural stem cells leads to aberrant postnatal olfactory bulb development and reduced size due to reduction of the olfactory bulb granule cell layer...
April 15, 2024: BMC Medicine
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REVIEW
Valentin A Bärreiter, Toni L Meister
In recent years, multiple coronaviruses have emerged, with the latest one, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing a global pandemic. Besides respiratory symptoms, some patients experienced extrapulmonary effects, such as cardiac damage or renal injury, indicating the broad tropism of SARS-CoV-2. The ability of the virus to effectively invade the renal cellular environment can eventually cause tissue-specific damage and disease. Indeed, patients with severe coronavirus disease 2019 exhibited a variety of symptoms such as acute proximal tubular injury, ischemic collapse, and severe acute tubular necrosis resulting in irreversible kidney failure...
April 13, 2024: Current Opinion in Microbiology
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JOURNAL ARTICLE
Tarjei Øvrebotten, Albulena Mecinaj, Knut Stavem, Waleed Ghanima, Eivind Brønstad, Michael T Durheim, Tøri V Lerum, Tony Josefsen, Jostein Grimsmo, Siri L Heck, Torbjørn Omland, Charlotte B Ingul, Gunnar Einvik, Peder L Myhre
BACKGROUND: COVID-19 has been associated with cardiac troponin T (cTnT) elevations and changes in cardiac structure and function, but the link between cardiac dysfunction and high-sensitive cardiac troponin T (hs-cTnT) in the acute and convalescent phase is unclear. OBJECTIVE: To assess whether hs-cTnT concentrations are associated with cardiac dysfunction and structural abnormalities after hospitalization for COVID-19, and to evaluate the performance of hs-cTnT to rule out cardiac pathology...
April 13, 2024: BMC Cardiovascular Disorders
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JOURNAL ARTICLE
Yelba Castellon-Lopez, Savanna L Carson, Katherine T Ward, Karina D Ramirez, Lynn Phan Vo, Tony Kuo, Teresa Seeman, Stefanie D Vassar, Laura Trejo, Ellen Eidem, María P Aranda, Arleen F Brown
BACKGROUND: Evidence-based programs (EBPs) for older adults effectively improve health outcomes. However, there is a limited understanding of the unique needs of service providers as they consider adopting, implementing, and maintaining programs for older minority adults in low-income communities with limited aging services. METHODS: We conducted semi-structured interviews with key informants of community-based organizations (CBOs) to understand implementation and sustainability needs of CBOs within four racial and ethnically diverse Los Angeles County geographic areas...
April 13, 2024: BMC Health Services Research
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JOURNAL ARTICLE
Anjela L Vogel, Katharine J Thompson, Daniel Straub, Florin Musat, Tony Gutierrez, Sara Kleindienst
Polycyclic aromatic hydrocarbon (PAH) contamination in marine environments range from low-diffusive inputs to high loads. The influence of PAH concentration on the expression of functional genes (e.g., those encoding ring-hydroxylating dioxygenases; RHDs), has been overlooked in PAH biodegradation studies. However, understanding marker-gene expression under different PAH loads can help monitor and predict bioremediation efficiency. Here, we followed the expression (via RNA sequencing) of Cycloclasticus pugetii strain PS-1 in cell suspension experiments under different naphthalene (100 and 30 mg L-1) concentrations...
April 13, 2024: FEMS Microbiology Ecology
#35
JOURNAL ARTICLE
Anthony Bergin, Michael Christmas, Wei Lian Tan, Yuming Ding, Lei Lin, Myat Myat Khaing, Tony Rahman
No abstract text is available yet for this article.
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#36
JOURNAL ARTICLE
Yuming Ding, Gonzalo Chincilla, Ann Vandeleur, Tony Rahman
No abstract text is available yet for this article.
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#37
JOURNAL ARTICLE
E Giuliani Meredith, Edith Filion, Sergio Faria, Vijayananda Kundapur, Toni Vu Thi Trinh Thuc, Benjamin H Lok, Srinivas Raman, Houda Bahig, Joanna M Laba, Pencilla Lang, Alexander V Louie, Andrew Hope, George B Rodrigues, Andrea Bezjak, Marie-Pierre Campeau, Marie Duclos, Scott Bratman, Anand Swaminath, Rohan Salunkhe, Andrew Warner, David A Palma
INTRODUCTION: The use of stereotactic body radiotherapy (SBRT) for tumors in close proximity to the central mediastinal structures has been associated with a high risk of toxicity. This study (BLINDED FOR REVIEW) aimed to determine the maximally tolerated dose (MTD) of SBRT for ultra-central (UC) non-small cell lung carcinoma (NSCLC), using a time-to-event continual reassessment methodology (TITE-CRM). METHODS: Patients with T1-3N0M0 (≤ 6 cm) NSCLC were eligible...
April 11, 2024: International Journal of Radiation Oncology, Biology, Physics
#38
JOURNAL ARTICLE
Saad Moughal, Fathallah Ismail Islim, Hamed Nejadhamzeeigilani, Nayyar Saleem, Tony Goddard, Tufail Patankar
INTRODUCTION: Endovascular treatment of wide neck aneurysms remains complicated with a determined and continuous technological effort towards treatment options that can offer safer and efficacious outcomes. The Woven Endobridge device was introduced in 2010 and has become a mainstay endovascular treatment for wide neck and large intracranial aneurysms. A recent review of the Woven Endobridge Clinical Assessment of Intrasaccular Aneurysm Therapy (WEBCAST) and WEBCAST2 trials and the five-year follow-up of patients was published...
April 13, 2024: Interventional Neuroradiology
#39
JOURNAL ARTICLE
Anees Bahji, David Crockford, Jennifer Brasch, Christian Schutz, Leslie Buckley, Marlon Danilewitz, Simon Dubreucq, Michael Mak, Tony P George
No abstract text is available yet for this article.
April 13, 2024: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
#40
JOURNAL ARTICLE
João Ferreira, Tony Jin, Jochen Mannhart, Thierry Giamarchi, Michele Filippone
We study noninteracting fermionic systems undergoing continuous monitoring and driven by biased reservoirs. Averaging over the measurement outcomes, we derive exact formulas for the particle and heat flows in the system. We show that these currents feature competing elastic and inelastic components, which depend nontrivially on the monitoring strength γ. We highlight that monitor-induced inelastic processes lead to nonreciprocal currents, allowing one to extract work from measurements without active feedback control...
March 29, 2024: Physical Review Letters
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